id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261253-btwx2vxo	Yip, Timothy T. C.	Application of ProteinChip Array Profiling in Serum Biomarker Discovery for Patients Suffering From Severe Acute Respiratory Syndrome	2007		.txt	text/plain	3836	310	66	By protein chip array profiling technology, a number of serum biomarkers that might be useful in monitoring the clinical course of SARS patients were identified. The serum profiling spectra in SARS patients were acquired, baseline subtracted and analyzed in parallel with those from the control subjects by Ciphergen ProteinChip Software 3.0.2 with their peak intensities compared by a nonparametric two sample Mann-Whitney-U test. More than twelve peaks were differentially expressed in SARS patients with one at m/z of 11,695 (later identified to be serum amyloid A protein), which had increase in peak intensity correlating with the extent of SARS-coronavirus induced pneumonia as defined by a serial chest X-ray opacity score. In a recent article, the discovery of 12 upor downregulated serum biomarkers were reported in SARS patients by a novel protein chip array profiling approach (1014) with one biomarker appears to be useful in monitoring the extent of pneumonia (15) .	./cache/cord-261253-btwx2vxo.txt	./txt/cord-261253-btwx2vxo.txt