id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261059-rcpx4god	Brenner, Steven Robert	Erythropoietin Induced Hemoglobin Sub‐Unit Beta may Stimulate Innate Immune RNA Virus Pattern Recognition, Suppress Reactive Oxygen Species, Reduce ACE2 Viral Doorway Opening and Neutrophil Extracellular Traps against Covid‐19	2020-07-09		.txt	text/plain	869	55	34	Erythropoietin may stimulate innate immunity against RNA viruses, such as Covid‐19, through hemoglobin sub‐unit Beta acting on the retinoic acid inducible gene I (RIG‐1) and melanoma differentiation associated gene 5 (MDA5) viral pattern recognition receptors, causing interferon production and also maintains the vascular endothelium, a major target of SARS‐CoV‐2, possibly reducing thrombotic events which are becoming increasingly recognized complications of COVID19. Possibly hemoglobin (HB), especially subunit beta also contributed to recovery, since HB participates in innate immunity through differentially regulating the retinoic acid inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5), which are involved in viral recognition and mobilizing an interferon response. (Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection (Covid-Thelium), including syndecan-1, a marker of degradation of glycocalyx, D-dimers plasma levels association with thrombotic events, and von Willibrandt Factor, Viscoelastic testing and Vascular endothelial Growth Factor Receptor type 1.	./cache/cord-261059-rcpx4god.txt	./txt/cord-261059-rcpx4god.txt