id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260854-v7wgb6mr	Colafrancesco, Serena	COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?	2020-05-05		.txt	text/plain	3340	160	37	The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term "hyperferritinemic syndrome" and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic inflammatory reaction and "hyperferritinemic syndromes" are all characterized by high serum ferritin and a life-threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi-organ failure. In this review, we analyze the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and we underline the similarities between this condition and "hyperferritinemic syndromes" which would allow considering this entity as the fifth member of the spectrum of inflammatory conditions. The umbrella term "hyperferritinemic syndrome" encompasses four clinical conditions, macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS), and septic shock, all characterized by high serum ferritin and a life -threatening hyper-inflammation sustained by a cytokines storm which eventually leads to multi -organ failure [1] .	./cache/cord-260854-v7wgb6mr.txt	./txt/cord-260854-v7wgb6mr.txt