id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260772-n5q2yi7j	Ji, Dong	Reply to: ‘No evidence for an increased liver uptake of SARS-CoV-2 in metabolic associated fatty liver disease’	2020-05-06		.txt	text/plain	405	34	57	title: Reply to: 'No evidence for an increased liver uptake of SARS-CoV-2 in metabolic associated fatty liver disease' Secondly, this is in keeping to our hypothesis that dysregulated hepatic innate immunity in patients with MAFLD contribute to the pathogenesis of COVID-19. 2 The liver is enriched with innate immune cells (such as macrophages, natural killer, natural killer T, and γδ T cells) 3 and due to its rich blood supply from the small bowel, circulation of the virus via the hepatic reticular system is expected. Hepatic innate immunity populations are potent cytokine producers and there are reports that obesity and NAFLD were associated with increased production of pro-inflammatory cytokines like TNF-α by adipose cells and Kupffer cells. No evidence for an increased liver uptake of SARS-CoV-2 in metabolic associated fatty liver disease of the link between the dysregulated hepatic innate immunity and COVID-19.	./cache/cord-260772-n5q2yi7j.txt	./txt/cord-260772-n5q2yi7j.txt