id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260132-lqpk3ig7	Quartuccio, Luca	Urgent avenues in the treatment of COVID-19: Targeting downstream inflammation to prevent catastrophic syndrome	2020-04-19		.txt	text/plain	2463	116	39	Currently, the humanized monoclonal antibody anti-interleukin-6 receptor (anti-IL-6R), namely tocilizumab, appears as a promising tool to turn off the cytokine storm, which dramatically complicates the course of the infection in some patients, causing a rapidly fatal acute respiratory distress syndrome. Importantly, SARS-CoV patients admitted to the Intensive Care Unit showed higher white blood cell and neutrophil counts, as well as higher levels of D-dimer, creatine kinase, and creatine, emphasizing the role of the systemic inflammation downstream the virus infection, and the transformation of the infectious disease into a systemic immunological and inflammatory disease. Lung pathology in 2003 SARS-CoV patients showed epithelial cell proliferation and desquamation, hyaline membranes formation along alveolar walls and cells infiltration (lymphocytes, neutrophils, and monocytes) during the early stage of the disease, while, of note, increased fibrosis and multinucleated epithelial giant cells formation at a later stage, highlighting the existence of a two-phase lung injury.	./cache/cord-260132-lqpk3ig7.txt	./txt/cord-260132-lqpk3ig7.txt