id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260077-xf4sofyc	Sawalha, Amr H.	Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients	2020-04-08		.txt	text/plain	2598	143	45	title: Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients Oxidative stress induced by viral infections exacerbates the DNA methylation defect in lupus, possibly resulting in further ACE2 hypomethylation and enhanced viremia. Oxidative stress induced by viral infections exacerbates the DNA methylation defect in lupus, possibly resulting in further ACE2 hypomethylation and enhanced viremia. Examining whole-genome DNA methylation data generated using an array-based approach, we observe significant hypomethylation in the ACE2 gene in this T cell subset compared to KIR − CD11a low T cells isolated from the same lupus patients (Fig. 1A) . Therefore, it is reasonable to suggest the possibility that the DNA methylation defect in lupus patients, exacerbated by oxidative stress generated from SARS-CoV-2 infection, will further enhance viral entry in lupus patients through epigenetic de-repression of ACE2 and increased ACE2 expression.	./cache/cord-260077-xf4sofyc.txt	./txt/cord-260077-xf4sofyc.txt