id author title date pages extension mime words sentences flesch summary cache txt cord-259808-82drb14x Andrews, Paul L R COVID‐19, nausea, and vomiting 2020-10-05 .txt text/plain 7911 404 46 Considering the likely effects of SARS-CoV-2 on the digestive tract (discussed further), a relationship between symptoms such as nausea/vomiting and diarrhea would not be unexpected but identifying the time of onset of each postinfection is essential to assessing their relative relevance for diagnosis. There are no formal studies at present so we have reviewed the effects of SARS-CoV-2 (and other coronaviruses) on the digestive tract in the light of knowledge of the established mechanisms of nausea and vomiting; this is the same approach that has been used to understand the pathogenesis of other symptoms (e.g. diarrhoea 10 ). We hypothesize that SARS-CoV-2 would induce acute (first few days postinfection) nausea and vomiting by causing the release of key hormones from the enteroendocrine cells (EECs) in the mucosa of the upper GI tract or after gaining direct entry into the blood, by acting directly within the brainstem. ./cache/cord-259808-82drb14x.txt ./txt/cord-259808-82drb14x.txt