id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258576-ywbyflas	Bösmüller, Hans	The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation	2020-06-30		.txt	text/plain	3628	207	44	We present the pulmonary findings in four cases of fatal COVID-19 with a spectrum of lung pathology reflecting disease course and duration, invasive therapies, and laboratory features. Based on conventional criteria, respiratory insufficiency therefore might be considered unlikely direct cause of death, but this case and recently published autopsy data indicate that pulmonary microvascular changes are an important and distinguishing feature of COVID-19 and may contribute to hypoxemia and acute cardiac insufficiency. Irrespective of the severity of pulmonary changes, however, all 4 patients showed SARS-CoV-2 RNA in lung tissues but failed to show detectable levels of viral RNA in other organs studied. The laboratory findings observed in patients 2 and 3 reflect common risk factors of fatal outcome, namely, lymphopenia; increased D-dimers; evidence of massive systemic inflammation including high levels of CRP, procalcitonin, and IL-6 during acute disease; and in the final stages massive ALT/AST elevation [1, 3, 4, 7, 11, 20] .	./cache/cord-258576-ywbyflas.txt	./txt/cord-258576-ywbyflas.txt