id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258382-ep73us0e	Braga, Cássia L.	The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19	2020-07-13		.txt	text/plain	2990	195	46	8, 9 According to Zhou et al, SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor to invade and infect cells. These proteins bud into the endoplasmic reticulum-Golgi intermediate compartment (ERGIC); new viral particles are then assembled and released to infect new target cells comes from the observation that endosomal alkalization induced by ammonium chloride inhibited SARS-CoV-2 replication. Once a hypertensive patient is infected with SARS-CoV-2, sensitization of the immune system toward an overactivation of the inflammatory response could be associated with subsequent development of cytokine storm. Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS	./cache/cord-258382-ep73us0e.txt	./txt/cord-258382-ep73us0e.txt