id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258242-xblxjlb5	Liu, Tengwen	Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal Multi-Scale Treatment Strategy for Septic Syndrome in COVID-19	2020-09-15		.txt	text/plain	5215	310	44	Recent studies reported that many critically ill COVID-19 patients developed typical septic syndrome, including inflammatory injury, immune dysfunction, coagulation disorder, and multiple organ failure (Bellinvia et al., 2020; Coronado et al., 2020; . Current studies reported that severe COVID-19 patients with septic syndrome mainly showed abnormal pathological features, including virus infection and tissue damage, excessive inflammation in early stage but immune suppression in late stage, and coagulation dysfunction . Since the data of systems pharmacology illustrated that SFH may regulate several key targets and biological processes of sepsis, such as PPARG in inflammatory response, GSK3b and MAPK14 in cell proliferation, and PTGS2 in coagulation, we hypothesized that SFH improves the condition of critically ill COVID-19 patients with septic syndrome by ameliorating lung injury, suppressing excessive inflammation but enhancing the capacity of pathogen phagocytosis and killing, and improving the function of blood coagulation.	./cache/cord-258242-xblxjlb5.txt	./txt/cord-258242-xblxjlb5.txt