id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258152-3udtsvga	Dawood, Ali Adel	Tunicamycin, an anticancer drug and inhibitor of N- linked glycosylation proteins is reliable to treat COVID-19	2020-10-20		.txt	text/plain	2965	174	50	The glycans in some proteins play a pivotal role in protein folding, oligomerization, quality control, sorting, and transport so the hindering of N-linked glycosylation of glycoproteins will prevent assembly of the virion. SARS-CoV is one of the viruses contain N-linked glycoproteins which are glycosylated by the transfer of core oligosaccharides from a dolichol pyrophosphate carrier to asparagine residues on the polypeptide [2] . Furthermore, HE protein of MHV was found to be modified by N-linked glycosylation and was inhibited by tunicamycin but not monensin. The inhibition Nlinked glycosylation of SARS-CoV 8ab protein by tunicamycin is not completely understood [33, 34] . HE and 8ab proteins of SARS-CoV glycosylation are inhibited by tunicamycin. Since tunicamycin has long been used as an anti-cancer and can inhibit glycoproteins of coronaviruses, we recommend using this drug to treat the SARS-CoV-2.	./cache/cord-258152-3udtsvga.txt	./txt/cord-258152-3udtsvga.txt