id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257876-nzjp1hrz	Yang, Wenzhong	Origin-independent analysis links SARS-CoV-2 local genomes with COVID-19 incidence and mortality	2020-09-14		.txt	text/plain	3319	192	55	Genomic annotation of the BLAST hits also showed that viruses from geographic regions with severe infections tended to have more dynamic genomic regions in the SARS-CoV-2 receptor-binding domain (RBD) and receptor-binding motif (RBM) of the spike protein (S protein). We collected all available raw sequencing data for SARS-CoV-2 from the four sequencing platforms (Illumina, BGI, Ion-Torrent and Nanopore) deposited in the National Center for Biotechnology Information (NCBI) Short Reads Archive (SRA) database as of 15 April 2020 (Supplementary Table S1 ). The BLAST hit score (BHS) is a metric based on the similarity between a high-quality read of a SARS-CoV-2 sample and each assembled genome in the coronavirus databases (Methods). To investigate the dynamic binding between RBM and ACE2, we implemented protein structure dockings between the modeled S proteins (with and without the 'hidden mutations' in the alignments of 4I.C1) and human ACE2 protein using HDOCK [26] The threshold for the high-quality reads from BGI and Illumina platforms is 0.9 (marked by a dash line) and that for Ion-Torrent and Nanopore is 0.2 (marked by a dash line).	./cache/cord-257876-nzjp1hrz.txt	./txt/cord-257876-nzjp1hrz.txt