id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257820-4qmajxtb	Abate, Giulia	Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action	2020-08-21		.txt	text/plain	4086	241	45	On the other hand, we cannot exclude that, in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) positive subjects, the virus infection could have long-term consequences, leading to chronic medical conditions such as dementia and neurodegenerative disease. Based on the belief that the tissue distribution of host receptors are generally consistent with the tropism of the virus [35] , ACE2 expression and its modulation in CNS might aid in dissecting the invasion rate and distribution of SARS-CoV-2 in the brain area. Recently, in the UK Biobank Community Cohort (n = 451,367), the ApoE e4e4 (homozygous) genotype was also found associated with an increased risk of severe COVID-19 infection, independent of preexisting dementia, cardiovascular disease, and type-2 diabetes [81] . All of these hypotheses about the theoretical impact of SARS-CoV-2 brain infection on Alzheimer's disease risk are summarized Table 1 . Theoretical impact of SARS-CoV-2 brain infection on Alzheimer's disease risk. AD, Alzheimer's disease; Aβ, Beta-amyloid; ACE2, Angiotensin-Converting Enzyme 2; NO, nitric oxide.	./cache/cord-257820-4qmajxtb.txt	./txt/cord-257820-4qmajxtb.txt