id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257789-pdybfft6	Diamond, Betty	SARS-CoV-2 and interferon blockade	2020-11-09		.txt	text/plain	3583	200	43	We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. Here we propose that the systemic inflammation seen in Covid-19 patients results from the activation of two intersecting systems, the renin-angiotensin system (RAS) and the kallikrein-bradykinin system (Diamond 2020) . The engagement of these pathways helps explain how severe Covid-19 infection is characterized by massive inflammation in multiple target organs, a poor anti-viral response with little production of interferon, and little participation of the adaptive immune system. As we have hypothesized that some of the inflammation induced in severe, and perhaps even moderate, Covid-19 is the result of dysregulation of the RAS and kallikrein-bradykinin pathways, the associated players serve as potential therapeutic targets ( Fig. 1 ) As mentioned above, ACE inhibitors and AT1 blockers (ARBs) are approved and safe drugs.	./cache/cord-257789-pdybfft6.txt	./txt/cord-257789-pdybfft6.txt