id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257140-ge15qrqg	Perkmann, T.	Increasing both specificity and sensitivity of SARS-CoV-2 antibody tests by using an adaptive orthogonal testing approach	2020-11-07		.txt	text/plain	3949	255	51	Methods To increase sensitivity, cut-offs of three commercially available SARS-CoV-2 automated assays (Roche, Abbott, and DiaSorin) were reduced according to published values in a pre-pandemic specificity cohort (n=1117) and a SARS-CoV-2 positive cohort (n=64). In our cohort, regardless of whether the assays were used for screening or confirmation, combining Roche and Abbott delivered the best overall performance (+~10% sensitivity compared to the single tests and 100% specificity). The disadvantage of this test strategy, which was recently shown in a study for the SARS-CoV-2 antibody tests from Abbott, Roche, and DiaSorin (19) , is that the gain in specificity usually comes at the expense of sensitivity and therefore increases the number of false negatives of individual tests. The Abbott Anti-SARS-CoV-2 IgG test, in contrast, reached 100.0% specificity only when followed by the Roche assay; in the other combinations, it remained slightly below, as a few false-positives persisted (99.8-99.9%).	./cache/cord-257140-ge15qrqg.txt	./txt/cord-257140-ge15qrqg.txt