id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257058-wf6oxzrk	Kim, Sinae	The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene	2020-10-26		.txt	text/plain	3332	237	61	The S gene of SARS-CoV, which encodes for the spike glycoprotein on the viral envelope, recognizes a receptor on the membrane of specific host cells. The present study with novel mutations in critical RBD of S gene may explain the high pathogenicity of SARS-CoV2 through precise biochemistry result with recombinant spike proteins as well as cell infectivity experiment. The alignment of four SARS-CoV2 spike amino acid sequences compared to the wild type sequence revealed that there are two additional mutations in the critical RBD and another mutation in subdomain (SD) 2, which is very close to the known mutation residue D614G (Figs. A recent study reported a single point mutation in which amino acid residue aspartic acid 614 replaced by glycine (D614G) in S gene, resulting in enhanced infectivity of SARS-CoV2 (18) . However, two novel mutations in S gene of Korean COVID-19 in the Korean patients were present in RBD (Fig. 6 , green bar), a site that is important for binding to ACE2 receptor on the host cell membrane.	./cache/cord-257058-wf6oxzrk.txt	./txt/cord-257058-wf6oxzrk.txt