id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257022-6vw88jib	SHANG, Lei	Polymorphism of SARS-CoV Genomes	2006-04-30		.txt	text/plain	2739	144	61	Abstract In this work, severe acute respiratory syndrome associated coronavirus (SARS-CoV) genome BJ202 (AY864806) was completely sequenced. In this work, the genome of one SARS-CoV isolated directly from the stool sample of a SARS patient was completely sequenced. We aligned 116 complete genome sequences of SARS-CoV (including BJ202 ) to analyze their single nucleotide polymorphism (SNPs). The 21.9-23.9 kb region, which falls into OrfS, had the third highest mutation frequency, in which 39 polymorphic sites were found in the nearly 2 kb stretch of genomic sequence (1 9.5 SNPs in 1 kb). Although it was reported that the in vitro mutation rate of the SARS-CoV in Vero cell passage was negligible['81, there might be difference between the genomic sequences obtained directly from clinical samples and from isolates of the cell culture. In this work, we completed the sequencing of SARS-CoV genome directly from the stool sample and analyzed the polymorphism of the SARS-CoV genome.	./cache/cord-257022-6vw88jib.txt	./txt/cord-257022-6vw88jib.txt