id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256893-3sh87h2x	Yang, Li	COVID-19: immunopathogenesis and Immunotherapeutics	2020-07-25		.txt	text/plain	5347	300	42	The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. The number of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is rapidly increasing worldwide. The effect of elevated cytokine production on clinical manifestations Increasing evidence shows that viral infection can induce severe syndromes of shock and organ failure; 8,57 this phenomenon was also investigated for COVID-19. Treg cell-based therapy The dysregulated inflammatory processes caused by SARS-CoV-2 in patients with severe COVID-19 are partially due to the dysfunction of Tregs, which are responsible for inhibiting inflammation.	./cache/cord-256893-3sh87h2x.txt	./txt/cord-256893-3sh87h2x.txt