id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256023-21b5hanj	Dowdell, A. K.	Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon	2020-08-04		.txt	text/plain	3829	246	56	We also highlight significant diversity in SARS-CoV-2 sequences in Oregon, including a large number of rare mutations, indicative that these genomes could be utilized for outbreak tracing. Genomic sequencing is rapidly emerging as an orthogonal strategy to RT-PCR for outbreak monitoring as the sequence specificity uncovered in individual SARS-CoV-2 isolates has shown significant utility for the epidemiological investigation of outbreak origins as well as the early identification of possible functional changes to the virus that may affect transmission rates or associated clinical outcomes. In order to assess the heterogeneity of SARS-CoV-2 genomes across OR, a total of 204 nasopharyngeal swab patient specimens (representing 188 unique patients) were sequenced from diverse clinical sites across OR. Next, we sought to determine whether sequence variants in the isolated SARS-CoV-2 genomes were associated with differential clinical manifestation of COVID-19 in the patients.	./cache/cord-256023-21b5hanj.txt	./txt/cord-256023-21b5hanj.txt