id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255913-430lrbyx	Brufsky, Adam	DC/L‐SIGNs of Hope in the COVID‐19 Pandemic	2020-05-06		.txt	text/plain	1518	76	49	The current pandemic and its pleotropic effects can be explained in part by interaction between SARS‐CoV‐2 spike protein S, the ACE2/L‐SIGN/CD209 receptor on the type II alveolar cell of the lung, and the DC‐SIGN receptor on the respiratory dendritic cell (DC) and associated endothelial cells. The current pandemic and its pleotropic effects can be explained in part by interaction between SARS-CoV-2 spike protein S, the ACE2/L-SIGN/CD209 receptor on the type II alveolar cell of the lung, and the DC-SIGN receptor on the respiratory dendritic cell (DC) and associated endothelial cells. L-SIGN is expressed on human type II alveolar cells, is associated with ACE2 10 , and can enhance ACE2 mediated binding and cellular entry of viral pseudotypes expressing the spike protein S of SARS-CoV 9 . De-glycosylation reduces infectivity of viral pseudotypes expressing SARS-CoV spike protein 13 and specific asparagine glycosylation sites in three clusters within the SARS-CoV S protein appear critical for DC/L-SIGN mediated, but not ACE2 mediated, SARS Co-V pseudotype entry into cells 13 .	./cache/cord-255913-430lrbyx.txt	./txt/cord-255913-430lrbyx.txt