id author title date pages extension mime words sentences flesch summary cache txt cord-255872-e2b7ox6b Sallam, M. Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa: Phylogenetic and mutation analysis study 2020-08-25 .txt text/plain 5129 380 61 This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation, that has a presumed fitness advantage. Similar to other RNA viruses, SARS-CoV-2 can be the subject of phylogenetic analysis due to its high evolutionary rate, and the application of molecular clock analysis might be of value to determine the timing of introductions of large clusters that imply networks of transmission (Duffy et al., 2008; Forster et al., 2020; Pybus and Rambaut, 2009 ). The total number of MENA SARS-CoV-2 S gene sequences that were included in final analysis was 553, distributed as follows: Oman (n=159), KSA (n=140), Egypt (Table 1) . Phylogenetic analysis of the MENA S gene SARS-CoV-2 sequences showed a relatively low level of phylogenetic clustering (15%), which hints to a large number of virus introductions into the region. ./cache/cord-255872-e2b7ox6b.txt ./txt/cord-255872-e2b7ox6b.txt