id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255782-w6nfkdok	Chikhale, Rupesh V.	Sars-cov-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach	2020-06-22		.txt	text/plain	5638	276	51	somnifera in comparison to reference drugs (hydroxychloroquine, lopinavir and remdesivir) against two different protein targets, that is, NSP15 endoribonuclease and prefusion spike RBD from SARS-CoV-2 using in-silico docking simulation and molecular dynamics (MD) study. The top three binding energy scorer ligand to each protein, that is, QGRG, Withanoside X and Ashwagandhanolide for spike RBD and QGRG, Dihydrowithaferin A and Withanolide N for NSP15 Endoribonuclease were selected for further MD study. Therefore, in the present study 100 ns of MD simulations were performed for all selected best six docked complexes to observe how the interaction pattern of the binding site of NSP15 endoribonuclease and spike RBD from SARS CoV-2 adapts to the docked bioactive. The phytochemicals Ashwagandhanolide, QGRG and Withanoside X in complex with the SARS-CoV-2 spike protein (PDB: 6M0J) were selected for the MDS based on molecular docking study results.	./cache/cord-255782-w6nfkdok.txt	./txt/cord-255782-w6nfkdok.txt