id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255415-sr81j7my	Heller, Lindsay K.	Mustela Vison ACE2 Functions as a Receptor for Sars-Coronavirus	2006		.txt	text/plain	1487	97	62	However, SARS-CoV-like viruses isolated from palm civets appeared to be under strong selective pressure and are genetically most similar to viruses infecting humans early in the outbreak. Human, palm civet, rat, mouse, chicken, and mink ACE2 were compared to identify differences that are important in species specificity and to discern regions within ACE2 that may impact its function as a SARS-CoV receptor. Expression of ACE2 RNA in SARS-CoV susceptible human (Huh7, HEK293T), African green monkey (VeroE6), and Mv1Lu cell lines 7 was analyzed by RT-PCR (chapter 4.8 this volume). 7 The complete open reading frame of human ACE2 (hACE2) or mvACE2 was amplified from RNA isolated from the Huh7 or Mv1Lu cell line, respectively. Our data demonstrate that mvACE2 RNA is expressed by SARS-CoV susceptible Mv1Lu cells, that it is closely related to palm civet ACE2, and that mvACE2 is a functional receptor for SARS-CoV.	./cache/cord-255415-sr81j7my.txt	./txt/cord-255415-sr81j7my.txt