id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255413-8o884nyp	Hotez, Peter J.	The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement	2020-04-17		.txt	text/plain	1707	104	35	From studies conducted in laboratory animals, there are additional concerns about immune enhancement and the role of potential host immunopathology resulting from experimental human COVID-19 vaccines. From studies conducted in laboratory animals, there are additional concerns about immune enhancement and the role of potential host immunopathology resulting from experimental human COVID-19 vaccines. Beyond direct virus-induced pathology, immune enhancement associated with eosinophilic infiltration and immunopathology is a potential safety concern linked to first-generation vaccines to prevent severe acute respiratory syndrome (SARS) (12) . While vaccinia and other vectored vaccines induce substantial immune enhancement in both the lungs and liver of experimental animals (20) (21) (22) (23) (24) , which in some cases have been linked to viral expression of the N protein (15) , none of these studies specifically examined Th17 responses. A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology	./cache/cord-255413-8o884nyp.txt	./txt/cord-255413-8o884nyp.txt