id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254957-jqp1gto6	Klann, Kevin	Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication	2020-08-11		.txt	text/plain	7002	411	50	We employed a SARS-CoV-2 infection system in permissible human cells to study signaling changes by phospho-proteomics. Inhibition of GFR downstream signaling by five compounds prevented SARS-CoV-2 replication in cells, assessed by cytopathic effect, viral dsRNA production, and viral RNA release into the supernatant. Additionally, we found carbon 160 metabolism among the pathways showing significantly increased phosphorylation upon SARS-CoV-2 infection (Table S4 ) in addition to previously described changes of total protein levels of enzymes part of glycolysis and carbon metabolism (Bojkova et al., 2020 )( Figure S3 ). We mapped identified members of GFR signaling and their respective phosphorylation differences upon SARS-CoV-2 infection ( Figure 3C ) revealing an extensive overall increase in phosphorylation of the whole pathway, including related components for cytoskeleton remodeling and receptor endocytosis. Growth factor receptor signaling was highly activated upon infection and its inhibition prevented SARS-CoV-2 replication in cells.	./cache/cord-254957-jqp1gto6.txt	./txt/cord-254957-jqp1gto6.txt