id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254505-mjj8xrer	Kannan, Saathvik R.	Infectivity of SARS-CoV-2: there Is Something More than D614G?	2020-09-15		.txt	text/plain	1917	130	65	To gain insight into the distribution of mutations in SARS-CoV-2 nonstructural proteins (nsps) and structural proteins, we analyzed protein sequences (n = 7232) from the United States (n = 6302), Europe (n = 420), China (n = 104), and India (n = 406), and determined the mutations with respect to Wuhan-Hu-1 isolate (NCBI Reference Sequence: NC_045512.2). The results of the temporal analysis of the mutation frequency of P323L (nsp12), C241U (5'UTR) and D614G (S-protein) show that P323L was consistently present in the viruses that had D614G mutation and C241U started coevolving with D614G sometime late January 2020 (Fig. 1b) . A mutation of D614 to G614 should result in the loss of these interactions, which could alter the dynamics of S-protein conformational changes during SARS-CoV-2 infection. Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex cell doi The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity cell doi	./cache/cord-254505-mjj8xrer.txt	./txt/cord-254505-mjj8xrer.txt