id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252873-4tazhf40	Kruglikov, Ilja L.	The role of adipocytes and adipocyte‐like cells in the severity of COVID‐19 infections	2020-04-27		.txt	text/plain	2295	128	47	Coronavirus disease‐2019 (COVID‐19), caused by the highly pathogenic virus SARS‐CoV‐2, demonstrates high morbidity and mortality caused by development of a severe acute respiratory syndrome connected with extensive pulmonary fibrosis (PF). Expression of angiotensin‐converting enzyme 2 (ACE2 ‐ the functional receptor for SARS‐CoV) ‐ is upregulated in adipocytes of obese and diabetic patients, which turns adipose tissue into a potential target and viral reservoir. Similar to the recently established adipocyte‐myofibroblast transition (AMT), pulmonary lipofibroblasts located in the alveolar interstitium and closely related to classical adipocytes, demonstrate the ability to transdifferentiate into myofibroblasts that play an integral part of PF. Recently it was shown that another anti-diabetic drug, metformin, accelerates resolution of pulmonary fibrosis by inducing trans-differentiation of myofibroblasts into lipofibroblasts (18) . Adipose tissue can serve as a viral reservoir, whereas transdifferentiation of pulmonary lipofibroblasts into myofibroblasts can contribute to the development of PF and thus is likely to influence the clinical severity of COVID-19.	./cache/cord-252873-4tazhf40.txt	./txt/cord-252873-4tazhf40.txt