id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252015-9oiwcn8q	Niu, Alex	COVID-19 in allogeneic stem cell transplant: high false-negative probability and role of CRISPR and convalescent plasma	2020-06-15		.txt	text/plain	1278	82	49	Shortly thereafter, RT-PCR/CRISPR was performed on a blood sample collected on hospital day 36 for clinical purposes and demonstrated strong detection of SARS-CoV-2 RNA (Fig. 1c) . Here, we present two cases of ASCT recipients who presented with respiratory illnesses, initially testing negative for SARS-CoV-2 with conventional RT-PCR, then positive with the more sensitive RT-PCR/CRISPR technique. Our findings suggest that ASCT recipients with negative nasopharyngeal SARS-CoV-2 RT-PCR, but evidence of lower respiratory tract disease, might indeed have COVID-19 that can be detected using a CRISPR-based platform. While safety concerns with performing bronchoscopy remain high with this infection, and COVID-19specific treatments depend on securing a positive test, it may be beneficial to pursue diagnosis with other tissue sources, such as whole blood or plasma. In conclusion, early diagnosis and treatment of COVID-19 is crucial in ASCT recipients, and evaluation regarding the use of other tissue sources for detection of SARS-CoV-2 along with multimodality therapy is required in the continual evolution of this pandemic.	./cache/cord-252015-9oiwcn8q.txt	./txt/cord-252015-9oiwcn8q.txt