id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-221611-eeybl35x	Vijayan, Ramachandran	Structure-based inhibitor screening of natural products against NSP15 of SARS- CoV-2 revealed Thymopentin and Oleuropein as potent inhibitors	2020-07-28		.txt	text/plain	3083	190	48	Here, we screened Selleckchem Natural product database of compounds against the NSP15, Thymopentin and Oleuropein showed highest binding energies. The structure of SARS-CoV-2 NSP15 protein is very similar to other Coronavirus NSP15 monomers, consisting of mainly three regions: the N-terminal domain, a subsequent middle domain, and a catalytic C-terminal nidoviral RNA uridylate-specific endoribonuclease domain. In order to design specific inhibitors against the Non-structural protein 15 (NSP15), Libraries of Selleckchem Natural products (https://www.selleckchem.com/screening/natural-productlibrary.html) were chosen for Virtual screening [24] [25] [26] . After the docking studies, the Molecular dynamic simulation [25] [26] [27] was performed for the top five screened compounds (Thymopentin, Ginsenoside, Oleuropein, Akebia Saponin D and Keampferitrin), to understand the binding stability of the docked complexes. In this study, structure based virtual screening followed by the validation through Molecular dynamic simulation approaches were carried out to find antiviral leads against NSP15 of SARS-CoV-2.	./cache/cord-221611-eeybl35x.txt	./txt/cord-221611-eeybl35x.txt