id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-191741-2vuiafv0	Schifanella, L.	Massive viral replication and cytopathic effects in early COVID-19 pneumonia	2020-04-30		.txt	text/plain	1953	94	46	Here we show that SARS-CoV-2 replication and cytopathic effects in type II alveolar pneumocytes causes focal lung injury in an individual with no history of pulmonary symptoms. Ground glass opacities or patchy infiltrates in the lungs in CT images of asymptomatic SARS-CoV-2 infected individuals [5] [6] [7] suggest that lung infection and associated tissue injury may be detectable in individuals who did not have severe pneumonia or respiratory failure 7 . We have already shown images that suggested that vRNA+ macrophages could acquire vRNA by phagocytosis of infected type II pneumocytes or vRNA released from lysed cells (Fig. 1, 2) , and now show further evidence in support of that conclusion. We show in a SARS-CoV-2 infected individual with ostensibly early infection, who had no known history of pulmonary symptoms, that there was a region of the lung with focal pneumonia in which massive SARS-CoV-2 replication and cytopathic effects in type II alveolar pneumocytes directly contributes to lung pathology.	./cache/cord-191741-2vuiafv0.txt	./txt/cord-191741-2vuiafv0.txt