id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-154844-nuqx3tv6	Misirli, Goksel	A comparative analysis for SARS-CoV-2	2020-04-08		.txt	text/plain	1660	112	58	Comparative analyses particularly can play a key role to reveal structural changes in proteins due to mutations, which can lead to behavioural changes, such as the increased binding of the SARS-CoV-2 surface glycoprotein to human ACE2 receptors. Starting with a SARS-CoV-2 genome sequence, the report shows visualising DNA sequence features, deriving amino acid sequences, and aligning different genomes to analyse mutations and differences. The report provides further insights into how the SARS-CoV-2 surface glycoprotein mutated for higher binding affinity to human ACE2 receptors, compared to the SARS-CoV protein, by integrating existing 3D protein models. Here, we integrated secondary structure predictions and realigned the sequences in order to show how these five mutations may affect the binding of the SARS-CoV-2 protein ( Figure 6 ). Compared to the SARS-CoV secondary structures, both the CLC Genomics Workbench predictions and the SARS-CoV-2 '6W41' model reveal additional beta strands in the mutated region (shown using the dashed box in Figure 6 ) of the surface glycoprotein.	./cache/cord-154844-nuqx3tv6.txt	./txt/cord-154844-nuqx3tv6.txt