id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-153725-jjefjlx2	Sahoo, Suban K	Computational evidence on repurposing the anti-influenza drugs baloxavir acid and baloxavir marboxil against COVID-19	2020-09-02		.txt	text/plain	2219	116	55	In this communication, molecular docking analyses of two influenza antiviral drugs baloxavir acid (BXA) and baloxavir marboxil (BXM) were performed with the three therapeutic target proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), i.e., main protease (Mpro), papain-like protease (PLpro) and RNA-dependent RNA polymerase (RdRp). Considering the need of new potential drugs to repurpose against COVID-19 pandemic, this research was carried out to investigate the effective binding of the drugs BMX and BXA with the three functional proteins of SARS-CoV-2, i.e., Mpro, PLpro and RdRp. The molecular docking of the drugs were performed with the therapeutic target proteins and their affinity of binding at the active site was compared. Therefore, to provide computational evidence on the comparative potency of the two influenza antiviral drugs BXA and BXM (Fig. 1) , the molecular docking experiments were performed in Autodock Vina with the therapeutic target proteins of SARS-CoV-2, i.e., Mpro, PLpro and RdRp. The blind molecular docking was performed where the grid box was selected to cover the whole protein structure.	./cache/cord-153725-jjefjlx2.txt	./txt/cord-153725-jjefjlx2.txt