id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103662-a4ok5wqc	Tarek, M.	Custommune: a web tool to design personalized and population-targeted vaccine epitopes	2020-04-29		.txt	text/plain	8116	454	45	When applied to HIV-1, Custommune predicted personalized epitopes using patient specific Human Leukocyte Antigen (HLA) alleles and viral sequences, as well as the expected HLA-peptide binding strength and potential immune escape mutations. The results allowed the identification of peptides tailored for each population and predicted to elicit both CD8+ T-cell immunity and neutralizing antibodies against structurally conserved epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To this aim, by intersecting input data from patient-specific viral sequences and HLA alleles, Custommune provides an output of epitopes of desired length filtered for their predicted specificity, immunogenicity and mutation potential. Class I and Class II HLA alleles which were predicted by Custommune to bind RBDp and RBDg epitopes of SARS-CoV-2 were used to estimate potential vaccine coverage in the populations of interest.	./cache/cord-103662-a4ok5wqc.txt	./txt/cord-103662-a4ok5wqc.txt