id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-033334-p7szd86k	Mann, Jaclyn Kelly	The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19	2020-10-08		.txt	text/plain	7284	366	33	Enhanced phagocytic activity as well as cytokine production of macrophages Enhanced intestinal immune responses: dendritic cell maturation, Th1/Th2 balance restored and humoral immunity promoted [77, 78] Peptides Anti-inflammatory Downregulates IL-6 and TNF-␣ and myeloperoxidase activity in peritonitis Binds to angiotensin II receptor type 1 to inhibit angiotensin II pro-inflammatory activity ACE inhibitory activity (antihypertensive) [79] [80] [81] [82] Intact Iron-binding activity* Sequestering free iron [83] Intact and peptides Antioxidant* Sequestering free iron Free radical scavenging [79, 84] Lysozyme Intact and peptides Antiviral Inhibits viral entry by binding to cell receptors or virus -cationic and hydrophobic nature is required rather than enzymatic activity Binds nucleic acids Inhibits virus-induced cell fusion Affects cell signaling, including NF-B pathway, to influence susceptibility to infection [85] [86] [87] [88] Intact and/or peptides Antibacterial Hydrolyzes cell wall of gram-positive bacteria (enzyme activity) Insert into and form pores in negatively charged bacterial membranes [40] † Specific anticoronavirus activity has been demonstrated: inhibits SARS-CoV cell entry by binding to HSPGs; inhibits entry and postentry steps of SARS-CoV-2 replication and elevates interferon-stimulated genes in SARS-CoV-2-infected cells.	./cache/cord-033334-p7szd86k.txt	./txt/cord-033334-p7szd86k.txt