id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-029450-4rnrq78l	Prattichizzo, Francesco	Response to: Letter to the Editor on “Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. Cytokine Growth Factor Rev” by Eugenia Quiros-Roldan, Giorgio Biasiotto and Isabella Zanella	2020-07-18		.txt	text/plain	1570	73	45	Preliminary data on an Italian cohort suggest that only a minor portion of HIV-positive patients with probable SARS-CoV-2 infection died, which yields a low case-fatality rate if compared to other highrisk populations [3] . Of note, the mean age of all the four HIV-positive cohorts was lower compared to other reports showing data of SARS-CoV-2 infection in the general population [7] . On the basis of the literature above, we posit that testing for T-cell senescence markers (e.g. PD-1, Tim-3, CTLA-4, and TIGIT) [9] and measuring major inflammatory markers in HIV-SARS-CoV-2 co-infected patients is mandatory to disentangle the relevance of immune senescence and inflamm-aging in the COVID-19 outcome in this specific population. A randomized controlled trial evaluating the efficacy of a triple antiviral therapy with combined interferon beta-1b, ribavirin, and lopinavir-ritonavir on COVID-19 patients proved the superiority of the triple antiviral therapy compared to lopinavirritonavir alone in terms of improved clinical recovery and faster rate of viral clearance, with a striking suppression of IL-6 levels in the interferon arm of the study after 48 hours of treatment [17] .	./cache/cord-029450-4rnrq78l.txt	./txt/cord-029450-4rnrq78l.txt