id author title date pages extension mime words sentences flesch summary cache txt cord-027650-pl6qsojf Wang, Yijin SARS-CoV-2 infection in liver-Author’s reply 2020-06-23 .txt text/plain 1065 64 40 In light of the low percentage of hepatocytes expressing ACE2, but not absolute absence, it is not surprisingly that SARS-CoV-2 is capable of causing liver injury directly. It is therefore assumed that viral direct effect in liver might not operate absolutely through ACE2 expression, and other receptors could not be excluded. Alternatively, the finding of up-regulated ACE2 expression in hepatocytes in cirrhotic liver inspired us to speculate that SARS-CoV-2 infection might induce compensatory hyperplasia of hepatocytes, which are possibly derived from highly expressed ACE2 cholangiocytes [16] . All in all, our data fully support a direct role of SARS-CoV-2 in COVID-19 related hepatic impairment. SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway ./cache/cord-027650-pl6qsojf.txt ./txt/cord-027650-pl6qsojf.txt