id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-015516-hx7ktq8j	nan	In the Literature	2005-10-15		.txt	text/plain	1499	80	46	Experimental pulmonary infection with SARS coronavirus infection in mice reduced the expression of ACE2 in the lungs and, as also occurs in humans, caused diffuse lung injury. On the basis of these findings, the investigators proposed that the severe pulmonary alveolar injury seen in patients with SARS is the consequence of SARS coronavirus spike surface protein-associated down-regulation of ACE2. The authors suggest that recombinant ACE2 protein could be a potential therapeutic agent in this and related pulmonary infections and diffuse alveolar injuries. In patients with chronic infections involving the exit site or tunnel portion of peritoneal dialysis catheters, treatment with antibiotics and local care is often unsuccessful. This procedure was used by Crabtree and Burchette in 13 consecutive patients with chronic peritoneal dialysis catheter infections that had been present for a mean duration of 3.2 months, with successful results for all 13. Three patients subsequently had their catheters removed because of peritonitis without exit-site or tunnel infection at months 8-11.	./cache/cord-015516-hx7ktq8j.txt	./txt/cord-015516-hx7ktq8j.txt