id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323730-5iawbnua	Ohl, Kim	Oxidative stress in multiple sclerosis: Central and peripheral mode of action	2016-03-31		.txt	text/plain	9168	438	39	Whatever the trigger factors for lesion Experimental Neurology 277 (2016) [58] [59] [60] [61] [62] [63] [64] [65] [66] [67] Abbreviations: APCs, antigen-presenting cells; ARE, antioxidant response element; DMF, dimethyl fumarate; FAEs, fumaric acid esters; GSH, glutathione; HO, heme oxygenase; IFN, interferon; IL, interleukin; iNOS, inducible nitric oxide synthase; Keap1, Kelch ECH associating protein 1; MDSC, myeloid-derived suppressor cells; MMF, monomethyl fumarate; NQO1, NAD(P)H: quinone oxidoreductase 1; Nrf2, nuclear factor (erythroid-derived 2)-like 2; RNS, reactive nitrogen species; ROS, reactive oxygen species; S1P, sphingosine 1-phosphate; TGF, transforming growth factor; T h , T helper cell; T reg , regulatory T cell; Trx, thioredoxin. Furthermore, redox stress is important for the functional outcome during experimentally-induced adaptive-immunity responses; e.g. in a graft-versus-host disease mouse model, free radical scavenger therapy with NecroX-7 attenuates disease severity, probably via the induction of T reg cells (Im et al., 2015) and oxidative damage regulates antigen-specific T cell responses in agerelated macular degeneration (Cruz-Guilloty et al., 2014) .	./cache/cord-323730-5iawbnua.txt	./txt/cord-323730-5iawbnua.txt