id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295459-ffi1043k	Khan, Naseem Ahmed	Respiratory Syncytial Virus-Induced Oxidative Stress Leads to an Increase in Labile Zinc Pools in Lung Epithelial Cells	2020-05-27		.txt	text/plain	6785	345	54	Small interfering RNA (siRNA)-mediated knockdown of the ubiquitous zinc uptake transporter ZIP1 suggests that labile zinc levels are increased due to the increased uptake by RSV-infected cells as an antiviral response. Our results suggest that zinc homeostasis plays a critical role in the host response to RSV infection by regulating oxidative stress and inhibiting virus replication. As with A549 cells, we observed a time-dependent increase in labile zinc levels in SAECs infected with RSV without any effect on cell viability ( Fig. 2A and B) . To further confirm the role of oxidative stress in RSV infection, cells infected with RSV were treated with 300 M H 2 O 2 (one of the ROS) and virus titers were measured at 24 h p.i. As observed in the case of zinc chelation, addition of H 2 O 2 led to a modest but significant increase in RSV titers at 24 h p.i.	./cache/cord-295459-ffi1043k.txt	./txt/cord-295459-ffi1043k.txt