id sid tid token lemma pos cord-355477-7xd93aqv 1 1 key key JJ cord-355477-7xd93aqv 1 2 : : : cord-355477-7xd93aqv 1 3 cord-355477 cord-355477 NNP cord-355477-7xd93aqv 1 4 - - HYPH cord-355477-7xd93aqv 1 5 7xd93aqv 7xd93aqv CD cord-355477-7xd93aqv 1 6 authors author NNS cord-355477-7xd93aqv 1 7 : : : cord-355477-7xd93aqv 1 8 SATIJA SATIJA NNP cord-355477-7xd93aqv 1 9 , , , cord-355477-7xd93aqv 1 10 NAMITA NAMITA NNP cord-355477-7xd93aqv 1 11 ; ; : cord-355477-7xd93aqv 1 12 LAL LAL NNP cord-355477-7xd93aqv 1 13 , , , cord-355477-7xd93aqv 1 14 SUNIL SUNIL NNP cord-355477-7xd93aqv 1 15 K. K. NNP cord-355477-7xd93aqv 1 16 title title NN cord-355477-7xd93aqv 1 17 : : : cord-355477-7xd93aqv 1 18 The the DT cord-355477-7xd93aqv 1 19 Molecular Molecular NNP cord-355477-7xd93aqv 1 20 Biology Biology NNP cord-355477-7xd93aqv 1 21 of of IN cord-355477-7xd93aqv 1 22 SARS SARS NNP cord-355477-7xd93aqv 1 23 Coronavirus Coronavirus NNP cord-355477-7xd93aqv 1 24 date date NN cord-355477-7xd93aqv 1 25 : : : cord-355477-7xd93aqv 1 26 2007 2007 CD cord-355477-7xd93aqv 1 27 - - HYPH cord-355477-7xd93aqv 1 28 04 04 CD cord-355477-7xd93aqv 1 29 - - HYPH cord-355477-7xd93aqv 1 30 23 23 CD cord-355477-7xd93aqv 1 31 journal journal NN cord-355477-7xd93aqv 1 32 : : : cord-355477-7xd93aqv 1 33 Ann Ann NNP cord-355477-7xd93aqv 1 34 N N NNP cord-355477-7xd93aqv 1 35 Y Y NNP cord-355477-7xd93aqv 1 36 Acad Acad NNP cord-355477-7xd93aqv 2 1 Sci Sci NNP cord-355477-7xd93aqv 2 2 DOI DOI NNP cord-355477-7xd93aqv 3 1 : : : cord-355477-7xd93aqv 3 2 10.1196 10.1196 CD cord-355477-7xd93aqv 3 3 / / SYM cord-355477-7xd93aqv 3 4 annals.1408.002 annals.1408.002 NN cord-355477-7xd93aqv 3 5 sha sha NNP cord-355477-7xd93aqv 3 6 : : : cord-355477-7xd93aqv 3 7 903a916aa919be745e784051093ead1f38c473ef 903a916aa919be745e784051093ead1f38c473ef CD cord-355477-7xd93aqv 3 8 doc_id doc_id CD cord-355477-7xd93aqv 3 9 : : : cord-355477-7xd93aqv 3 10 355477 355477 CD cord-355477-7xd93aqv 3 11 cord_uid cord_uid NN cord-355477-7xd93aqv 3 12 : : : cord-355477-7xd93aqv 4 1 7xd93aqv 7xd93aqv CD cord-355477-7xd93aqv 4 2 abstract abstract JJ cord-355477-7xd93aqv 4 3 : : : cord-355477-7xd93aqv 4 4 Severe severe JJ cord-355477-7xd93aqv 4 5 acute acute JJ cord-355477-7xd93aqv 4 6 respiratory respiratory JJ cord-355477-7xd93aqv 4 7 syndrome syndrome NN cord-355477-7xd93aqv 4 8 ( ( -LRB- cord-355477-7xd93aqv 4 9 SARS SARS NNP cord-355477-7xd93aqv 4 10 ) ) -RRB- cord-355477-7xd93aqv 4 11 is be VBZ cord-355477-7xd93aqv 4 12 the the DT cord-355477-7xd93aqv 4 13 first first JJ cord-355477-7xd93aqv 4 14 emerging emerge VBG cord-355477-7xd93aqv 4 15 infectious infectious JJ cord-355477-7xd93aqv 4 16 disease disease NN cord-355477-7xd93aqv 4 17 of of IN cord-355477-7xd93aqv 4 18 the the DT cord-355477-7xd93aqv 4 19 21st 21st JJ cord-355477-7xd93aqv 4 20 century century NN cord-355477-7xd93aqv 4 21 that that WDT cord-355477-7xd93aqv 4 22 has have VBZ cord-355477-7xd93aqv 4 23 been be VBN cord-355477-7xd93aqv 4 24 highly highly RB cord-355477-7xd93aqv 4 25 transmissible transmissible JJ cord-355477-7xd93aqv 4 26 and and CC cord-355477-7xd93aqv 4 27 fatal fatal JJ cord-355477-7xd93aqv 4 28 and and CC cord-355477-7xd93aqv 4 29 was be VBD cord-355477-7xd93aqv 4 30 caused cause VBN cord-355477-7xd93aqv 4 31 by by IN cord-355477-7xd93aqv 4 32 a a DT cord-355477-7xd93aqv 4 33 previously previously RB cord-355477-7xd93aqv 4 34 unknown unknown JJ cord-355477-7xd93aqv 4 35 coronavirus coronavirus NN cord-355477-7xd93aqv 4 36 ( ( -LRB- cord-355477-7xd93aqv 4 37 SARS‐CoV SARS‐CoV NNP cord-355477-7xd93aqv 4 38 ) ) -RRB- cord-355477-7xd93aqv 4 39 . . . cord-355477-7xd93aqv 5 1 The the DT cord-355477-7xd93aqv 5 2 SARS SARS NNP cord-355477-7xd93aqv 5 3 epidemic epidemic NN cord-355477-7xd93aqv 5 4 in in IN cord-355477-7xd93aqv 5 5 2003 2003 CD cord-355477-7xd93aqv 5 6 resulted result VBD cord-355477-7xd93aqv 5 7 in in IN cord-355477-7xd93aqv 5 8 more more JJR cord-355477-7xd93aqv 5 9 than than IN cord-355477-7xd93aqv 5 10 8400 8400 CD cord-355477-7xd93aqv 5 11 SARS SARS NNP cord-355477-7xd93aqv 5 12 cases case NNS cord-355477-7xd93aqv 5 13 and and CC cord-355477-7xd93aqv 5 14 approximately approximately RB cord-355477-7xd93aqv 5 15 800 800 CD cord-355477-7xd93aqv 5 16 deaths death NNS cord-355477-7xd93aqv 5 17 . . . cord-355477-7xd93aqv 6 1 Existing exist VBG cord-355477-7xd93aqv 6 2 in in IN cord-355477-7xd93aqv 6 3 non‐identified non‐identified JJ cord-355477-7xd93aqv 6 4 animal animal NN cord-355477-7xd93aqv 6 5 reservoirs reservoir NNS cord-355477-7xd93aqv 6 6 , , , cord-355477-7xd93aqv 6 7 SARS‐CoV SARS‐CoV NNP cord-355477-7xd93aqv 6 8 continues continue VBZ cord-355477-7xd93aqv 6 9 to to TO cord-355477-7xd93aqv 6 10 represent represent VB cord-355477-7xd93aqv 6 11 a a DT cord-355477-7xd93aqv 6 12 threat threat NN cord-355477-7xd93aqv 6 13 to to IN cord-355477-7xd93aqv 6 14 humans human NNS cord-355477-7xd93aqv 6 15 although although IN cord-355477-7xd93aqv 6 16 more more JJR cord-355477-7xd93aqv 6 17 than than IN cord-355477-7xd93aqv 6 18 four four CD cord-355477-7xd93aqv 6 19 years year NNS cord-355477-7xd93aqv 6 20 have have VBP cord-355477-7xd93aqv 6 21 passed pass VBN cord-355477-7xd93aqv 6 22 since since IN cord-355477-7xd93aqv 6 23 a a DT cord-355477-7xd93aqv 6 24 large large JJ cord-355477-7xd93aqv 6 25 outbreak outbreak NN cord-355477-7xd93aqv 6 26 of of IN cord-355477-7xd93aqv 6 27 SARS SARS NNP cord-355477-7xd93aqv 6 28 , , , cord-355477-7xd93aqv 6 29 and and CC cord-355477-7xd93aqv 6 30 no no DT cord-355477-7xd93aqv 6 31 new new JJ cord-355477-7xd93aqv 6 32 cases case NNS cord-355477-7xd93aqv 6 33 have have VBP cord-355477-7xd93aqv 6 34 been be VBN cord-355477-7xd93aqv 6 35 reported report VBN cord-355477-7xd93aqv 6 36 . . . cord-355477-7xd93aqv 7 1 However however RB cord-355477-7xd93aqv 7 2 , , , cord-355477-7xd93aqv 7 3 we -PRON- PRP cord-355477-7xd93aqv 7 4 can can MD cord-355477-7xd93aqv 7 5 not not RB cord-355477-7xd93aqv 7 6 exclude exclude VB cord-355477-7xd93aqv 7 7 the the DT cord-355477-7xd93aqv 7 8 possibility possibility NN cord-355477-7xd93aqv 7 9 of of IN cord-355477-7xd93aqv 7 10 reemergence reemergence NN cord-355477-7xd93aqv 7 11 of of IN cord-355477-7xd93aqv 7 12 SARS SARS NNP cord-355477-7xd93aqv 7 13 . . . cord-355477-7xd93aqv 8 1 It -PRON- PRP cord-355477-7xd93aqv 8 2 is be VBZ cord-355477-7xd93aqv 8 3 hence hence RB cord-355477-7xd93aqv 8 4 necessary necessary JJ cord-355477-7xd93aqv 8 5 to to TO cord-355477-7xd93aqv 8 6 understand understand VB cord-355477-7xd93aqv 8 7 the the DT cord-355477-7xd93aqv 8 8 biology biology NN cord-355477-7xd93aqv 8 9 of of IN cord-355477-7xd93aqv 8 10 the the DT cord-355477-7xd93aqv 8 11 SARS‐CoV sars‐cov NN cord-355477-7xd93aqv 8 12 to to TO cord-355477-7xd93aqv 8 13 deal deal VB cord-355477-7xd93aqv 8 14 adequately adequately RB cord-355477-7xd93aqv 8 15 with with IN cord-355477-7xd93aqv 8 16 the the DT cord-355477-7xd93aqv 8 17 next next JJ cord-355477-7xd93aqv 8 18 outbreak outbreak NN cord-355477-7xd93aqv 8 19 , , , cord-355477-7xd93aqv 8 20 whenever whenever WRB cord-355477-7xd93aqv 8 21 it -PRON- PRP cord-355477-7xd93aqv 8 22 happens happen VBZ cord-355477-7xd93aqv 8 23 . . . cord-355477-7xd93aqv 9 1 The the DT cord-355477-7xd93aqv 9 2 SARS‐CoV sars‐cov NN cord-355477-7xd93aqv 9 3 is be VBZ cord-355477-7xd93aqv 9 4 a a DT cord-355477-7xd93aqv 9 5 novel novel JJ cord-355477-7xd93aqv 9 6 coronavirus coronavirus NN cord-355477-7xd93aqv 9 7 with with IN cord-355477-7xd93aqv 9 8 a a DT cord-355477-7xd93aqv 9 9 large large JJ cord-355477-7xd93aqv 9 10 ( ( -LRB- cord-355477-7xd93aqv 9 11 ∼30 ∼30 NNP cord-355477-7xd93aqv 9 12 thousand thousand CD cord-355477-7xd93aqv 9 13 nucleotides nucleotide NNS cord-355477-7xd93aqv 9 14 ) ) -RRB- cord-355477-7xd93aqv 10 1 positive‐sense positive‐sense NNP cord-355477-7xd93aqv 10 2 , , , cord-355477-7xd93aqv 10 3 single‐stranded single‐stranded NNP cord-355477-7xd93aqv 10 4 RNA RNA NNP cord-355477-7xd93aqv 10 5 containing contain VBG cord-355477-7xd93aqv 10 6 14 14 CD cord-355477-7xd93aqv 10 7 functional functional JJ cord-355477-7xd93aqv 10 8 open open JJ cord-355477-7xd93aqv 10 9 reading reading NN cord-355477-7xd93aqv 10 10 frames frame NNS cord-355477-7xd93aqv 10 11 ( ( -LRB- cord-355477-7xd93aqv 10 12 ORFs ORFs NNP cord-355477-7xd93aqv 10 13 ) ) -RRB- cord-355477-7xd93aqv 10 14 of of IN cord-355477-7xd93aqv 10 15 which which WDT cord-355477-7xd93aqv 10 16 2 2 CD cord-355477-7xd93aqv 10 17 large large JJ cord-355477-7xd93aqv 10 18 ORFs orf NNS cord-355477-7xd93aqv 10 19 constitute constitute VBP cord-355477-7xd93aqv 10 20 the the DT cord-355477-7xd93aqv 10 21 replicase replicase NN cord-355477-7xd93aqv 10 22 gene gene NN cord-355477-7xd93aqv 10 23 which which WDT cord-355477-7xd93aqv 10 24 encodes encode VBZ cord-355477-7xd93aqv 10 25 proteins protein NNS cord-355477-7xd93aqv 10 26 required require VBN cord-355477-7xd93aqv 10 27 for for IN cord-355477-7xd93aqv 10 28 viral viral JJ cord-355477-7xd93aqv 10 29 RNA RNA NNP cord-355477-7xd93aqv 10 30 syntheses synthesis NNS cord-355477-7xd93aqv 10 31 . . . cord-355477-7xd93aqv 11 1 The the DT cord-355477-7xd93aqv 11 2 remaining remain VBG cord-355477-7xd93aqv 11 3 12 12 CD cord-355477-7xd93aqv 11 4 ORFs orf NNS cord-355477-7xd93aqv 11 5 encode encode VBP cord-355477-7xd93aqv 11 6 the the DT cord-355477-7xd93aqv 11 7 4 4 CD cord-355477-7xd93aqv 11 8 structural structural JJ cord-355477-7xd93aqv 11 9 proteins protein NNS cord-355477-7xd93aqv 11 10 : : : cord-355477-7xd93aqv 11 11 spike spike NN cord-355477-7xd93aqv 11 12 , , , cord-355477-7xd93aqv 11 13 membrane membrane NN cord-355477-7xd93aqv 11 14 , , , cord-355477-7xd93aqv 11 15 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 11 16 and and CC cord-355477-7xd93aqv 11 17 envelope envelope NN cord-355477-7xd93aqv 11 18 ; ; : cord-355477-7xd93aqv 11 19 and and CC cord-355477-7xd93aqv 11 20 eight eight CD cord-355477-7xd93aqv 11 21 accessory accessory NN cord-355477-7xd93aqv 11 22 proteins protein NNS cord-355477-7xd93aqv 11 23 . . . cord-355477-7xd93aqv 12 1 The the DT cord-355477-7xd93aqv 12 2 viral viral JJ cord-355477-7xd93aqv 12 3 genome genome NN cord-355477-7xd93aqv 12 4 and and CC cord-355477-7xd93aqv 12 5 its -PRON- PRP$ cord-355477-7xd93aqv 12 6 expression expression NN cord-355477-7xd93aqv 12 7 within within IN cord-355477-7xd93aqv 12 8 the the DT cord-355477-7xd93aqv 12 9 host host NN cord-355477-7xd93aqv 12 10 cell cell NN cord-355477-7xd93aqv 12 11 undergoes undergo VBZ cord-355477-7xd93aqv 12 12 extensive extensive JJ cord-355477-7xd93aqv 12 13 translational translational JJ cord-355477-7xd93aqv 12 14 and and CC cord-355477-7xd93aqv 12 15 enzymatic enzymatic JJ cord-355477-7xd93aqv 12 16 processing processing NN cord-355477-7xd93aqv 12 17 to to TO cord-355477-7xd93aqv 12 18 form form VB cord-355477-7xd93aqv 12 19 the the DT cord-355477-7xd93aqv 12 20 4 4 CD cord-355477-7xd93aqv 12 21 structural structural JJ cord-355477-7xd93aqv 12 22 , , , cord-355477-7xd93aqv 12 23 8 8 CD cord-355477-7xd93aqv 12 24 accessory accessory NN cord-355477-7xd93aqv 12 25 and and CC cord-355477-7xd93aqv 12 26 16 16 CD cord-355477-7xd93aqv 12 27 nonstructural nonstructural JJ cord-355477-7xd93aqv 12 28 proteins protein NNS cord-355477-7xd93aqv 12 29 . . . cord-355477-7xd93aqv 13 1 In in IN cord-355477-7xd93aqv 13 2 an an DT cord-355477-7xd93aqv 13 3 effort effort NN cord-355477-7xd93aqv 13 4 to to TO cord-355477-7xd93aqv 13 5 understand understand VB cord-355477-7xd93aqv 13 6 the the DT cord-355477-7xd93aqv 13 7 molecular molecular JJ cord-355477-7xd93aqv 13 8 mechanisms mechanism NNS cord-355477-7xd93aqv 13 9 or or CC cord-355477-7xd93aqv 13 10 capsid capsid NN cord-355477-7xd93aqv 13 11 assembly assembly NN cord-355477-7xd93aqv 13 12 and and CC cord-355477-7xd93aqv 13 13 viral viral JJ cord-355477-7xd93aqv 13 14 pathogenesis pathogenesis NN cord-355477-7xd93aqv 13 15 , , , cord-355477-7xd93aqv 13 16 laboratories laboratory NNS cord-355477-7xd93aqv 13 17 around around IN cord-355477-7xd93aqv 13 18 the the DT cord-355477-7xd93aqv 13 19 world world NN cord-355477-7xd93aqv 13 20 have have VBP cord-355477-7xd93aqv 13 21 adopted adopt VBN cord-355477-7xd93aqv 13 22 a a DT cord-355477-7xd93aqv 13 23 variety variety NN cord-355477-7xd93aqv 13 24 of of IN cord-355477-7xd93aqv 13 25 approaches approach NNS cord-355477-7xd93aqv 13 26 to to IN cord-355477-7xd93aqv 13 27 answering answer VBG cord-355477-7xd93aqv 13 28 these these DT cord-355477-7xd93aqv 13 29 trivial trivial JJ cord-355477-7xd93aqv 13 30 questions question NNS cord-355477-7xd93aqv 13 31 . . . cord-355477-7xd93aqv 14 1 It -PRON- PRP cord-355477-7xd93aqv 14 2 has have VBZ cord-355477-7xd93aqv 14 3 been be VBN cord-355477-7xd93aqv 14 4 our -PRON- PRP$ cord-355477-7xd93aqv 14 5 effort effort NN cord-355477-7xd93aqv 14 6 to to TO cord-355477-7xd93aqv 14 7 consolidate consolidate VB cord-355477-7xd93aqv 14 8 all all DT cord-355477-7xd93aqv 14 9 information information NN cord-355477-7xd93aqv 14 10 known know VBN cord-355477-7xd93aqv 14 11 to to IN cord-355477-7xd93aqv 14 12 date date NN cord-355477-7xd93aqv 14 13 about about IN cord-355477-7xd93aqv 14 14 the the DT cord-355477-7xd93aqv 14 15 molecular molecular JJ cord-355477-7xd93aqv 14 16 mechanisms mechanism NNS cord-355477-7xd93aqv 14 17 of of IN cord-355477-7xd93aqv 14 18 the the DT cord-355477-7xd93aqv 14 19 SARS‐CoV sars‐cov NN cord-355477-7xd93aqv 14 20 into into IN cord-355477-7xd93aqv 14 21 this this DT cord-355477-7xd93aqv 14 22 chapter chapter NN cord-355477-7xd93aqv 14 23 to to TO cord-355477-7xd93aqv 14 24 update update VB cord-355477-7xd93aqv 14 25 our -PRON- PRP$ cord-355477-7xd93aqv 14 26 readership readership NN cord-355477-7xd93aqv 14 27 on on IN cord-355477-7xd93aqv 14 28 the the DT cord-355477-7xd93aqv 14 29 current current JJ cord-355477-7xd93aqv 14 30 status status NN cord-355477-7xd93aqv 14 31 of of IN cord-355477-7xd93aqv 14 32 research research NN cord-355477-7xd93aqv 14 33 . . . cord-355477-7xd93aqv 15 1 Severe severe JJ cord-355477-7xd93aqv 15 2 acute acute JJ cord-355477-7xd93aqv 15 3 respiratory respiratory JJ cord-355477-7xd93aqv 15 4 syndrome syndrome NN cord-355477-7xd93aqv 15 5 ( ( -LRB- cord-355477-7xd93aqv 15 6 SARS SARS NNP cord-355477-7xd93aqv 15 7 ) ) -RRB- cord-355477-7xd93aqv 15 8 is be VBZ cord-355477-7xd93aqv 15 9 a a DT cord-355477-7xd93aqv 15 10 newly newly RB cord-355477-7xd93aqv 15 11 emerged emerge VBN cord-355477-7xd93aqv 15 12 infectious infectious JJ cord-355477-7xd93aqv 15 13 disease disease NN cord-355477-7xd93aqv 15 14 that that WDT cord-355477-7xd93aqv 15 15 appeared appear VBD cord-355477-7xd93aqv 15 16 in in IN cord-355477-7xd93aqv 15 17 Guangdong Guangdong NNP cord-355477-7xd93aqv 15 18 Province Province NNP cord-355477-7xd93aqv 15 19 , , , cord-355477-7xd93aqv 15 20 mainland mainland NN cord-355477-7xd93aqv 15 21 China China NNP cord-355477-7xd93aqv 15 22 , , , cord-355477-7xd93aqv 15 23 in in IN cord-355477-7xd93aqv 15 24 November November NNP cord-355477-7xd93aqv 15 25 2002 2002 CD cord-355477-7xd93aqv 15 26 . . . cord-355477-7xd93aqv 16 1 By by IN cord-355477-7xd93aqv 16 2 March March NNP cord-355477-7xd93aqv 16 3 2003 2003 CD cord-355477-7xd93aqv 16 4 , , , cord-355477-7xd93aqv 16 5 the the DT cord-355477-7xd93aqv 16 6 disease disease NN cord-355477-7xd93aqv 16 7 had have VBD cord-355477-7xd93aqv 16 8 spread spread VBN cord-355477-7xd93aqv 16 9 globally globally RB cord-355477-7xd93aqv 16 10 and and CC cord-355477-7xd93aqv 16 11 by by IN cord-355477-7xd93aqv 16 12 July July NNP cord-355477-7xd93aqv 16 13 there there EX cord-355477-7xd93aqv 16 14 were be VBD cord-355477-7xd93aqv 16 15 8,447 8,447 CD cord-355477-7xd93aqv 16 16 probable probable JJ cord-355477-7xd93aqv 16 17 SARS SARS NNP cord-355477-7xd93aqv 16 18 cases case NNS cord-355477-7xd93aqv 16 19 including include VBG cord-355477-7xd93aqv 16 20 811 811 CD cord-355477-7xd93aqv 16 21 deaths death NNS cord-355477-7xd93aqv 16 22 reported report VBN cord-355477-7xd93aqv 16 23 from from IN cord-355477-7xd93aqv 16 24 32 32 CD cord-355477-7xd93aqv 16 25 countries country NNS cord-355477-7xd93aqv 16 26 or or CC cord-355477-7xd93aqv 16 27 regions region NNS cord-355477-7xd93aqv 16 28 worldwide worldwide RB cord-355477-7xd93aqv 16 29 to to IN cord-355477-7xd93aqv 16 30 the the DT cord-355477-7xd93aqv 16 31 WHO WHO NNP cord-355477-7xd93aqv 16 32 . . . cord-355477-7xd93aqv 17 1 The the DT cord-355477-7xd93aqv 17 2 etiological etiological JJ cord-355477-7xd93aqv 17 3 agent agent NN cord-355477-7xd93aqv 17 4 was be VBD cord-355477-7xd93aqv 17 5 identified identify VBN cord-355477-7xd93aqv 17 6 as as IN cord-355477-7xd93aqv 17 7 a a DT cord-355477-7xd93aqv 17 8 coronavirus coronavirus NN cord-355477-7xd93aqv 17 9 ( ( -LRB- cord-355477-7xd93aqv 17 10 CoV CoV NNP cord-355477-7xd93aqv 17 11 ) ) -RRB- cord-355477-7xd93aqv 17 12 1 1 CD cord-355477-7xd93aqv 17 13 and and CC cord-355477-7xd93aqv 17 14 the the DT cord-355477-7xd93aqv 17 15 complete complete JJ cord-355477-7xd93aqv 17 16 genome genome NN cord-355477-7xd93aqv 17 17 sequence sequence NN cord-355477-7xd93aqv 17 18 of of IN cord-355477-7xd93aqv 17 19 SARS SARS NNP cord-355477-7xd93aqv 17 20 - - HYPH cord-355477-7xd93aqv 17 21 CoV CoV NNP cord-355477-7xd93aqv 17 22 Tor2 Tor2 NNP cord-355477-7xd93aqv 17 23 ( ( -LRB- cord-355477-7xd93aqv 17 24 Toronto Toronto NNP cord-355477-7xd93aqv 17 25 ) ) -RRB- cord-355477-7xd93aqv 17 26 isolate isolate NN cord-355477-7xd93aqv 17 27 was be VBD cord-355477-7xd93aqv 17 28 published publish VBN cord-355477-7xd93aqv 17 29 in in IN cord-355477-7xd93aqv 17 30 April April NNP cord-355477-7xd93aqv 17 31 2003 2003 CD cord-355477-7xd93aqv 17 32 , , , cord-355477-7xd93aqv 17 33 which which WDT cord-355477-7xd93aqv 17 34 established establish VBD cord-355477-7xd93aqv 17 35 it -PRON- PRP cord-355477-7xd93aqv 17 36 as as IN cord-355477-7xd93aqv 17 37 a a DT cord-355477-7xd93aqv 17 38 novel novel JJ cord-355477-7xd93aqv 17 39 member member NN cord-355477-7xd93aqv 17 40 of of IN cord-355477-7xd93aqv 17 41 the the DT cord-355477-7xd93aqv 17 42 family family NN cord-355477-7xd93aqv 17 43 . . . cord-355477-7xd93aqv 18 1 2 2 LS cord-355477-7xd93aqv 18 2 , , , cord-355477-7xd93aqv 18 3 3 3 CD cord-355477-7xd93aqv 19 1 The the DT cord-355477-7xd93aqv 19 2 genome genome NN cord-355477-7xd93aqv 19 3 of of IN cord-355477-7xd93aqv 19 4 SARS SARS NNP cord-355477-7xd93aqv 19 5 - - HYPH cord-355477-7xd93aqv 19 6 CoV CoV NNP cord-355477-7xd93aqv 19 7 is be VBZ cord-355477-7xd93aqv 19 8 a a DT cord-355477-7xd93aqv 19 9 positive positive JJ cord-355477-7xd93aqv 19 10 sense sense NN cord-355477-7xd93aqv 19 11 single single RB cord-355477-7xd93aqv 19 12 - - HYPH cord-355477-7xd93aqv 19 13 stranded strand VBN cord-355477-7xd93aqv 19 14 ribonucleic ribonucleic NN cord-355477-7xd93aqv 19 15 acid acid NN cord-355477-7xd93aqv 19 16 ( ( -LRB- cord-355477-7xd93aqv 19 17 RNA RNA NNP cord-355477-7xd93aqv 19 18 ) ) -RRB- cord-355477-7xd93aqv 19 19 consisting consist VBG cord-355477-7xd93aqv 19 20 of of IN cord-355477-7xd93aqv 19 21 29,751 29,751 CD cord-355477-7xd93aqv 19 22 bases basis NNS cord-355477-7xd93aqv 19 23 . . . cord-355477-7xd93aqv 20 1 Phylogenetic phylogenetic JJ cord-355477-7xd93aqv 20 2 analysis analysis NN cord-355477-7xd93aqv 20 3 revealed reveal VBD cord-355477-7xd93aqv 20 4 that that IN cord-355477-7xd93aqv 20 5 this this DT cord-355477-7xd93aqv 20 6 CoV cov NN cord-355477-7xd93aqv 20 7 was be VBD cord-355477-7xd93aqv 20 8 only only RB cord-355477-7xd93aqv 20 9 moderately moderately RB cord-355477-7xd93aqv 20 10 related related JJ cord-355477-7xd93aqv 20 11 to to IN cord-355477-7xd93aqv 20 12 other other JJ cord-355477-7xd93aqv 20 13 known know VBN cord-355477-7xd93aqv 20 14 CoVs CoVs NNP cord-355477-7xd93aqv 20 15 , , , cord-355477-7xd93aqv 20 16 including include VBG cord-355477-7xd93aqv 20 17 two two CD cord-355477-7xd93aqv 20 18 human human JJ cord-355477-7xd93aqv 20 19 CoVs covs NN cord-355477-7xd93aqv 20 20 , , , cord-355477-7xd93aqv 20 21 HCoV HCoV NNP cord-355477-7xd93aqv 20 22 - - HYPH cord-355477-7xd93aqv 20 23 OC43 OC43 NNP cord-355477-7xd93aqv 20 24 and and CC cord-355477-7xd93aqv 20 25 HCoV-229E HCoV-229E NNP cord-355477-7xd93aqv 20 26 , , , cord-355477-7xd93aqv 20 27 known know VBN cord-355477-7xd93aqv 20 28 to to TO cord-355477-7xd93aqv 20 29 cause cause VB cord-355477-7xd93aqv 20 30 common common JJ cord-355477-7xd93aqv 20 31 colds cold NNS cord-355477-7xd93aqv 20 32 and and CC cord-355477-7xd93aqv 20 33 lower low JJR cord-355477-7xd93aqv 20 34 respiratory respiratory JJ cord-355477-7xd93aqv 20 35 tract tract NN cord-355477-7xd93aqv 20 36 infections infection NNS cord-355477-7xd93aqv 20 37 and and CC cord-355477-7xd93aqv 20 38 diarrhea diarrhea NN cord-355477-7xd93aqv 20 39 in in IN cord-355477-7xd93aqv 20 40 humans human NNS cord-355477-7xd93aqv 20 41 . . . cord-355477-7xd93aqv 21 1 The the DT cord-355477-7xd93aqv 21 2 clinical clinical JJ cord-355477-7xd93aqv 21 3 symptoms symptom NNS cord-355477-7xd93aqv 21 4 of of IN cord-355477-7xd93aqv 21 5 the the DT cord-355477-7xd93aqv 21 6 syndrome syndrome NN cord-355477-7xd93aqv 21 7 include include VBP cord-355477-7xd93aqv 21 8 fever fever NN cord-355477-7xd93aqv 21 9 , , , cord-355477-7xd93aqv 21 10 chills chill NNS cord-355477-7xd93aqv 21 11 , , , cord-355477-7xd93aqv 21 12 rigors rigor NNS cord-355477-7xd93aqv 21 13 , , , cord-355477-7xd93aqv 21 14 cough cough NN cord-355477-7xd93aqv 21 15 , , , cord-355477-7xd93aqv 21 16 and and CC cord-355477-7xd93aqv 21 17 headache headache NN cord-355477-7xd93aqv 21 18 and and CC cord-355477-7xd93aqv 21 19 the the DT cord-355477-7xd93aqv 21 20 pathological pathological JJ cord-355477-7xd93aqv 21 21 aspects aspect NNS cord-355477-7xd93aqv 21 22 include include VBP cord-355477-7xd93aqv 21 23 lymphopenia lymphopenia NNP cord-355477-7xd93aqv 21 24 , , , cord-355477-7xd93aqv 21 25 thrombocytopenia thrombocytopenia NN cord-355477-7xd93aqv 21 26 , , , cord-355477-7xd93aqv 21 27 elevated elevated JJ cord-355477-7xd93aqv 21 28 lactate lactate NN cord-355477-7xd93aqv 21 29 dehydrogenase dehydrogenase NN cord-355477-7xd93aqv 21 30 , , , cord-355477-7xd93aqv 21 31 and and CC cord-355477-7xd93aqv 21 32 creatine creatine NN cord-355477-7xd93aqv 21 33 kinase kinase NN cord-355477-7xd93aqv 21 34 levels level NNS cord-355477-7xd93aqv 21 35 . . . cord-355477-7xd93aqv 22 1 Although although IN cord-355477-7xd93aqv 22 2 currently currently RB cord-355477-7xd93aqv 22 3 the the DT cord-355477-7xd93aqv 22 4 spread spread NN cord-355477-7xd93aqv 22 5 of of IN cord-355477-7xd93aqv 22 6 the the DT cord-355477-7xd93aqv 22 7 virus virus NN cord-355477-7xd93aqv 22 8 seems seem VBZ cord-355477-7xd93aqv 22 9 to to TO cord-355477-7xd93aqv 22 10 be be VB cord-355477-7xd93aqv 22 11 confined confine VBN cord-355477-7xd93aqv 22 12 to to IN cord-355477-7xd93aqv 22 13 rigorous rigorous JJ cord-355477-7xd93aqv 22 14 and and CC cord-355477-7xd93aqv 22 15 timely timely JJ cord-355477-7xd93aqv 22 16 quarantine quarantine NN cord-355477-7xd93aqv 22 17 measures measure NNS cord-355477-7xd93aqv 22 18 ( ( -LRB- cord-355477-7xd93aqv 22 19 http://www.who.int/csr/sars/country/ http://www.who.int/csr/sars/country/ NNP cord-355477-7xd93aqv 22 20 table2003 table2003 NNP cord-355477-7xd93aqv 22 21 0923 0923 CD cord-355477-7xd93aqv 22 22 / / SYM cord-355477-7xd93aqv 22 23 en/ en/ NNP cord-355477-7xd93aqv 22 24 ) ) -RRB- cord-355477-7xd93aqv 22 25 , , , cord-355477-7xd93aqv 22 26 it -PRON- PRP cord-355477-7xd93aqv 22 27 may may MD cord-355477-7xd93aqv 22 28 still still RB cord-355477-7xd93aqv 22 29 be be VB cord-355477-7xd93aqv 22 30 circulating circulate VBG cord-355477-7xd93aqv 22 31 in in IN cord-355477-7xd93aqv 22 32 the the DT cord-355477-7xd93aqv 22 33 animal animal NN cord-355477-7xd93aqv 22 34 reservoir reservoir NN cord-355477-7xd93aqv 22 35 and and CC cord-355477-7xd93aqv 22 36 it -PRON- PRP cord-355477-7xd93aqv 22 37 is be VBZ cord-355477-7xd93aqv 22 38 impossible impossible JJ cord-355477-7xd93aqv 22 39 to to TO cord-355477-7xd93aqv 22 40 predict predict VB cord-355477-7xd93aqv 22 41 when when WRB cord-355477-7xd93aqv 22 42 it -PRON- PRP cord-355477-7xd93aqv 22 43 will will MD cord-355477-7xd93aqv 22 44 return return VB cord-355477-7xd93aqv 22 45 . . . cord-355477-7xd93aqv 23 1 Because because IN cord-355477-7xd93aqv 23 2 this this DT cord-355477-7xd93aqv 23 3 scare scare NN cord-355477-7xd93aqv 23 4 of of IN cord-355477-7xd93aqv 23 5 recurrence recurrence NN cord-355477-7xd93aqv 23 6 of of IN cord-355477-7xd93aqv 23 7 SARS SARS NNP cord-355477-7xd93aqv 23 8 looms loom VBZ cord-355477-7xd93aqv 23 9 over over IN cord-355477-7xd93aqv 23 10 mankind mankind NN cord-355477-7xd93aqv 23 11 , , , cord-355477-7xd93aqv 23 12 better well JJR cord-355477-7xd93aqv 23 13 monitoring monitoring NN cord-355477-7xd93aqv 23 14 of of IN cord-355477-7xd93aqv 23 15 SARS SARS NNP cord-355477-7xd93aqv 23 16 outbreaks outbreak NNS cord-355477-7xd93aqv 23 17 through through IN cord-355477-7xd93aqv 23 18 accurate accurate JJ cord-355477-7xd93aqv 23 19 diagnostic diagnostic JJ cord-355477-7xd93aqv 23 20 tests test NNS cord-355477-7xd93aqv 23 21 and and CC cord-355477-7xd93aqv 23 22 the the DT cord-355477-7xd93aqv 23 23 development development NN cord-355477-7xd93aqv 23 24 of of IN cord-355477-7xd93aqv 23 25 effective effective JJ cord-355477-7xd93aqv 23 26 antiviral antiviral JJ cord-355477-7xd93aqv 23 27 therapies therapy NNS cord-355477-7xd93aqv 23 28 are be VBP cord-355477-7xd93aqv 23 29 urgently urgently RB cord-355477-7xd93aqv 23 30 required require VBN cord-355477-7xd93aqv 23 31 . . . cord-355477-7xd93aqv 24 1 These these DT cord-355477-7xd93aqv 24 2 in in IN cord-355477-7xd93aqv 24 3 turn turn NN cord-355477-7xd93aqv 24 4 depend depend VBP cord-355477-7xd93aqv 24 5 directly directly RB cord-355477-7xd93aqv 24 6 on on RB cord-355477-7xd93aqv 24 7 better well JJR cord-355477-7xd93aqv 24 8 molecular molecular JJ cord-355477-7xd93aqv 24 9 understanding understanding NN cord-355477-7xd93aqv 24 10 of of IN cord-355477-7xd93aqv 24 11 the the DT cord-355477-7xd93aqv 24 12 SARS SARS NNP cord-355477-7xd93aqv 24 13 - - HYPH cord-355477-7xd93aqv 24 14 CoV CoV NNP cord-355477-7xd93aqv 24 15 infection infection NN cord-355477-7xd93aqv 24 16 cycle cycle NN cord-355477-7xd93aqv 24 17 . . . cord-355477-7xd93aqv 25 1 Research research VB cord-355477-7xd93aqv 25 2 toward toward IN cord-355477-7xd93aqv 25 3 the the DT cord-355477-7xd93aqv 25 4 understanding understanding NN cord-355477-7xd93aqv 25 5 of of IN cord-355477-7xd93aqv 25 6 the the DT cord-355477-7xd93aqv 25 7 SARS SARS NNP cord-355477-7xd93aqv 25 8 virus virus NN cord-355477-7xd93aqv 25 9 at at IN cord-355477-7xd93aqv 25 10 a a DT cord-355477-7xd93aqv 25 11 molecular molecular JJ cord-355477-7xd93aqv 25 12 level level NN cord-355477-7xd93aqv 25 13 is be VBZ cord-355477-7xd93aqv 25 14 therefore therefore RB cord-355477-7xd93aqv 25 15 of of IN cord-355477-7xd93aqv 25 16 vital vital JJ cord-355477-7xd93aqv 25 17 importance importance NN cord-355477-7xd93aqv 25 18 to to TO cord-355477-7xd93aqv 25 19 combat combat VB cord-355477-7xd93aqv 25 20 SARS SARS NNP cord-355477-7xd93aqv 25 21 - - HYPH cord-355477-7xd93aqv 25 22 CoV CoV NNP cord-355477-7xd93aqv 25 23 infection infection NN cord-355477-7xd93aqv 25 24 if if IN cord-355477-7xd93aqv 25 25 another another DT cord-355477-7xd93aqv 25 26 SARS SARS NNP cord-355477-7xd93aqv 25 27 pandemic pandemic NN cord-355477-7xd93aqv 25 28 was be VBD cord-355477-7xd93aqv 25 29 to to TO cord-355477-7xd93aqv 25 30 occur occur VB cord-355477-7xd93aqv 25 31 in in IN cord-355477-7xd93aqv 25 32 the the DT cord-355477-7xd93aqv 25 33 future future NN cord-355477-7xd93aqv 25 34 . . . cord-355477-7xd93aqv 26 1 SARS SARS NNP cord-355477-7xd93aqv 26 2 mainly mainly RB cord-355477-7xd93aqv 26 3 shows show VBZ cord-355477-7xd93aqv 26 4 pneumonia pneumonia NN cord-355477-7xd93aqv 26 5 - - HYPH cord-355477-7xd93aqv 26 6 like like JJ cord-355477-7xd93aqv 26 7 symptoms symptom NNS cord-355477-7xd93aqv 26 8 and and CC cord-355477-7xd93aqv 26 9 the the DT cord-355477-7xd93aqv 26 10 lung lung NN cord-355477-7xd93aqv 26 11 is be VBZ cord-355477-7xd93aqv 26 12 pathologically pathologically RB cord-355477-7xd93aqv 26 13 the the DT cord-355477-7xd93aqv 26 14 most most RBS cord-355477-7xd93aqv 26 15 affected affected JJ cord-355477-7xd93aqv 26 16 organ organ NN cord-355477-7xd93aqv 26 17 . . . cord-355477-7xd93aqv 27 1 Detailed detailed JJ cord-355477-7xd93aqv 27 2 investigations investigation NNS cord-355477-7xd93aqv 27 3 , , , cord-355477-7xd93aqv 27 4 however however RB cord-355477-7xd93aqv 27 5 , , , cord-355477-7xd93aqv 27 6 suggest suggest VBP cord-355477-7xd93aqv 27 7 that that IN cord-355477-7xd93aqv 27 8 SARS SARS NNP cord-355477-7xd93aqv 27 9 is be VBZ cord-355477-7xd93aqv 27 10 a a DT cord-355477-7xd93aqv 27 11 systemic systemic JJ cord-355477-7xd93aqv 27 12 disease disease NN cord-355477-7xd93aqv 27 13 with with IN cord-355477-7xd93aqv 27 14 widespread widespread JJ cord-355477-7xd93aqv 27 15 extrapulmonary extrapulmonary JJ cord-355477-7xd93aqv 27 16 dissemination dissemination NN cord-355477-7xd93aqv 27 17 , , , cord-355477-7xd93aqv 27 18 resulting result VBG cord-355477-7xd93aqv 27 19 in in IN cord-355477-7xd93aqv 27 20 viral viral JJ cord-355477-7xd93aqv 27 21 shedding shedding NN cord-355477-7xd93aqv 27 22 in in IN cord-355477-7xd93aqv 27 23 respiratory respiratory JJ cord-355477-7xd93aqv 27 24 secretions secretion NNS cord-355477-7xd93aqv 27 25 , , , cord-355477-7xd93aqv 27 26 stools stool NNS cord-355477-7xd93aqv 27 27 , , , cord-355477-7xd93aqv 27 28 urine urine NN cord-355477-7xd93aqv 27 29 , , , cord-355477-7xd93aqv 27 30 and and CC cord-355477-7xd93aqv 27 31 possibly possibly RB cord-355477-7xd93aqv 27 32 even even RB cord-355477-7xd93aqv 27 33 in in IN cord-355477-7xd93aqv 27 34 sweat sweat NN cord-355477-7xd93aqv 27 35 . . . cord-355477-7xd93aqv 28 1 4 4 LS cord-355477-7xd93aqv 28 2 , , , cord-355477-7xd93aqv 28 3 5 5 CD cord-355477-7xd93aqv 28 4 Immunohistochemistry Immunohistochemistry NNP cord-355477-7xd93aqv 28 5 and and CC cord-355477-7xd93aqv 28 6 in in IN cord-355477-7xd93aqv 28 7 situ situ JJ cord-355477-7xd93aqv 28 8 hybridization hybridization NN cord-355477-7xd93aqv 28 9 of of IN cord-355477-7xd93aqv 28 10 organs organ NNS cord-355477-7xd93aqv 28 11 from from IN cord-355477-7xd93aqv 28 12 four four CD cord-355477-7xd93aqv 28 13 SARS SARS NNP cord-355477-7xd93aqv 28 14 patients patient NNS cord-355477-7xd93aqv 28 15 who who WP cord-355477-7xd93aqv 28 16 died die VBD cord-355477-7xd93aqv 28 17 revealed reveal VBD cord-355477-7xd93aqv 28 18 that that IN cord-355477-7xd93aqv 28 19 the the DT cord-355477-7xd93aqv 28 20 virus virus NN cord-355477-7xd93aqv 28 21 was be VBD cord-355477-7xd93aqv 28 22 found find VBN cord-355477-7xd93aqv 28 23 not not RB cord-355477-7xd93aqv 28 24 only only RB cord-355477-7xd93aqv 28 25 in in IN cord-355477-7xd93aqv 28 26 the the DT cord-355477-7xd93aqv 28 27 lung lung NN cord-355477-7xd93aqv 28 28 and and CC cord-355477-7xd93aqv 28 29 intestine intestine NN cord-355477-7xd93aqv 28 30 , , , cord-355477-7xd93aqv 28 31 but but CC cord-355477-7xd93aqv 28 32 also also RB cord-355477-7xd93aqv 28 33 in in IN cord-355477-7xd93aqv 28 34 the the DT cord-355477-7xd93aqv 28 35 liver liver NN cord-355477-7xd93aqv 28 36 , , , cord-355477-7xd93aqv 28 37 distal distal JJ cord-355477-7xd93aqv 28 38 convoluted convoluted JJ cord-355477-7xd93aqv 28 39 renal renal JJ cord-355477-7xd93aqv 28 40 tubules tubule NNS cord-355477-7xd93aqv 28 41 , , , cord-355477-7xd93aqv 28 42 sweat sweat NN cord-355477-7xd93aqv 28 43 glands gland NNS cord-355477-7xd93aqv 28 44 , , , cord-355477-7xd93aqv 28 45 parathyroid parathyroid NN cord-355477-7xd93aqv 28 46 , , , cord-355477-7xd93aqv 28 47 pituitary pituitary NN cord-355477-7xd93aqv 28 48 , , , cord-355477-7xd93aqv 28 49 pancreas pancrea NNS cord-355477-7xd93aqv 28 50 , , , cord-355477-7xd93aqv 28 51 adrenal adrenal JJ cord-355477-7xd93aqv 28 52 gland gland NN cord-355477-7xd93aqv 28 53 , , , cord-355477-7xd93aqv 28 54 and and CC cord-355477-7xd93aqv 28 55 cerebrum cerebrum NN cord-355477-7xd93aqv 28 56 . . . cord-355477-7xd93aqv 29 1 4 4 CD cord-355477-7xd93aqv 29 2 SARS SARS NNP cord-355477-7xd93aqv 29 3 - - HYPH cord-355477-7xd93aqv 29 4 CoV CoV NNP cord-355477-7xd93aqv 29 5 RNA RNA NNP cord-355477-7xd93aqv 29 6 was be VBD cord-355477-7xd93aqv 29 7 detected detect VBN cord-355477-7xd93aqv 29 8 in in IN cord-355477-7xd93aqv 29 9 the the DT cord-355477-7xd93aqv 29 10 lung lung NN cord-355477-7xd93aqv 29 11 , , , cord-355477-7xd93aqv 29 12 small small JJ cord-355477-7xd93aqv 29 13 and and CC cord-355477-7xd93aqv 29 14 large large JJ cord-355477-7xd93aqv 29 15 bowels bowel NNS cord-355477-7xd93aqv 29 16 , , , cord-355477-7xd93aqv 29 17 lymph lymph NN cord-355477-7xd93aqv 29 18 nodes node NNS cord-355477-7xd93aqv 29 19 , , , cord-355477-7xd93aqv 29 20 spleen spleen NNS cord-355477-7xd93aqv 29 21 , , , cord-355477-7xd93aqv 29 22 liver liver NN cord-355477-7xd93aqv 29 23 , , , cord-355477-7xd93aqv 29 24 heart heart NN cord-355477-7xd93aqv 29 25 , , , cord-355477-7xd93aqv 29 26 kidney kidney NN cord-355477-7xd93aqv 29 27 , , , cord-355477-7xd93aqv 29 28 and and CC cord-355477-7xd93aqv 29 29 skeletal skeletal JJ cord-355477-7xd93aqv 29 30 muscle muscle NN cord-355477-7xd93aqv 29 31 , , , cord-355477-7xd93aqv 29 32 in in IN cord-355477-7xd93aqv 29 33 descending descend VBG cord-355477-7xd93aqv 29 34 order order NN cord-355477-7xd93aqv 29 35 of of IN cord-355477-7xd93aqv 29 36 viral viral JJ cord-355477-7xd93aqv 29 37 load load NN cord-355477-7xd93aqv 29 38 per per IN cord-355477-7xd93aqv 29 39 gram gram NN cord-355477-7xd93aqv 29 40 of of IN cord-355477-7xd93aqv 29 41 tissue tissue NN cord-355477-7xd93aqv 29 42 using use VBG cord-355477-7xd93aqv 29 43 reverse reverse JJ cord-355477-7xd93aqv 29 44 - - HYPH cord-355477-7xd93aqv 29 45 transcriptase transcriptase NN cord-355477-7xd93aqv 29 46 polymerase polymerase NN cord-355477-7xd93aqv 29 47 chain chain NN cord-355477-7xd93aqv 29 48 reaction reaction NN cord-355477-7xd93aqv 29 49 . . . cord-355477-7xd93aqv 30 1 5 5 LS cord-355477-7xd93aqv 31 1 The the DT cord-355477-7xd93aqv 31 2 virus virus NN cord-355477-7xd93aqv 31 3 seems seem VBZ cord-355477-7xd93aqv 31 4 to to TO cord-355477-7xd93aqv 31 5 gain gain VB cord-355477-7xd93aqv 31 6 entry entry NN cord-355477-7xd93aqv 31 7 into into IN cord-355477-7xd93aqv 31 8 the the DT cord-355477-7xd93aqv 31 9 target target NN cord-355477-7xd93aqv 31 10 cells cell NNS cord-355477-7xd93aqv 31 11 by by IN cord-355477-7xd93aqv 31 12 direct direct JJ cord-355477-7xd93aqv 31 13 membrane membrane NN cord-355477-7xd93aqv 31 14 fusion fusion NN cord-355477-7xd93aqv 31 15 at at IN cord-355477-7xd93aqv 31 16 the the DT cord-355477-7xd93aqv 31 17 target target NN cord-355477-7xd93aqv 31 18 cell cell NN cord-355477-7xd93aqv 31 19 surface surface NN cord-355477-7xd93aqv 31 20 . . . cord-355477-7xd93aqv 32 1 Apart apart RB cord-355477-7xd93aqv 32 2 from from IN cord-355477-7xd93aqv 32 3 this this DT cord-355477-7xd93aqv 32 4 it -PRON- PRP cord-355477-7xd93aqv 32 5 has have VBZ cord-355477-7xd93aqv 32 6 been be VBN cord-355477-7xd93aqv 32 7 postulated postulate VBN cord-355477-7xd93aqv 32 8 that that IN cord-355477-7xd93aqv 32 9 the the DT cord-355477-7xd93aqv 32 10 SARS SARS NNP cord-355477-7xd93aqv 32 11 - - HYPH cord-355477-7xd93aqv 32 12 CoV CoV NNP cord-355477-7xd93aqv 32 13 may may MD cord-355477-7xd93aqv 32 14 gain gain VB cord-355477-7xd93aqv 32 15 cell cell NN cord-355477-7xd93aqv 32 16 entry entry NN cord-355477-7xd93aqv 32 17 via via IN cord-355477-7xd93aqv 32 18 pH ph JJ cord-355477-7xd93aqv 32 19 - - HYPH cord-355477-7xd93aqv 32 20 dependent dependent JJ cord-355477-7xd93aqv 32 21 endocytosis endocytosis NN cord-355477-7xd93aqv 32 22 . . . cord-355477-7xd93aqv 33 1 The the DT cord-355477-7xd93aqv 33 2 spike spike NN cord-355477-7xd93aqv 33 3 protein protein NN cord-355477-7xd93aqv 33 4 of of IN cord-355477-7xd93aqv 33 5 the the DT cord-355477-7xd93aqv 33 6 virus virus NN cord-355477-7xd93aqv 33 7 is be VBZ cord-355477-7xd93aqv 33 8 the the DT cord-355477-7xd93aqv 33 9 key key JJ cord-355477-7xd93aqv 33 10 player player NN cord-355477-7xd93aqv 33 11 in in IN cord-355477-7xd93aqv 33 12 this this DT cord-355477-7xd93aqv 33 13 regard regard NN cord-355477-7xd93aqv 33 14 . . . cord-355477-7xd93aqv 34 1 6 6 CD cord-355477-7xd93aqv 35 1 A a DT cord-355477-7xd93aqv 35 2 metallopeptidase metallopeptidase NN cord-355477-7xd93aqv 35 3 , , , cord-355477-7xd93aqv 35 4 angiotensin angiotensin NN cord-355477-7xd93aqv 35 5 - - HYPH cord-355477-7xd93aqv 35 6 converting convert VBG cord-355477-7xd93aqv 35 7 enzyme enzyme NN cord-355477-7xd93aqv 35 8 2 2 CD cord-355477-7xd93aqv 35 9 ( ( -LRB- cord-355477-7xd93aqv 35 10 ACE2 ACE2 NNP cord-355477-7xd93aqv 35 11 ) ) -RRB- cord-355477-7xd93aqv 36 1 , , , cord-355477-7xd93aqv 36 2 the the DT cord-355477-7xd93aqv 36 3 C c NN cord-355477-7xd93aqv 36 4 - - HYPH cord-355477-7xd93aqv 36 5 type type NN cord-355477-7xd93aqv 36 6 lectin lectin NN cord-355477-7xd93aqv 36 7 CD209L cd209l NN cord-355477-7xd93aqv 36 8 ( ( -LRB- cord-355477-7xd93aqv 36 9 also also RB cord-355477-7xd93aqv 36 10 known know VBN cord-355477-7xd93aqv 36 11 as as IN cord-355477-7xd93aqv 36 12 L l NN cord-355477-7xd93aqv 36 13 - - HYPH cord-355477-7xd93aqv 36 14 SIGN SIGN NNP cord-355477-7xd93aqv 36 15 ) ) -RRB- cord-355477-7xd93aqv 36 16 , , , cord-355477-7xd93aqv 36 17 and and CC cord-355477-7xd93aqv 36 18 DC DC NNP cord-355477-7xd93aqv 36 19 - - HYPH cord-355477-7xd93aqv 36 20 SIGN sign NN cord-355477-7xd93aqv 36 21 bind bind VBP cord-355477-7xd93aqv 36 22 SARS SARS NNP cord-355477-7xd93aqv 36 23 - - HYPH cord-355477-7xd93aqv 36 24 CoV CoV NNP cord-355477-7xd93aqv 36 25 , , , cord-355477-7xd93aqv 36 26 but but CC cord-355477-7xd93aqv 36 27 ACE2 ACE2 NNP cord-355477-7xd93aqv 36 28 appears appear VBZ cord-355477-7xd93aqv 36 29 to to TO cord-355477-7xd93aqv 36 30 be be VB cord-355477-7xd93aqv 36 31 the the DT cord-355477-7xd93aqv 36 32 key key JJ cord-355477-7xd93aqv 36 33 functional functional JJ cord-355477-7xd93aqv 36 34 receptor receptor NN cord-355477-7xd93aqv 36 35 for for IN cord-355477-7xd93aqv 36 36 the the DT cord-355477-7xd93aqv 36 37 virus virus NN cord-355477-7xd93aqv 36 38 . . . cord-355477-7xd93aqv 37 1 The the DT cord-355477-7xd93aqv 37 2 ACE2 ACE2 NNP cord-355477-7xd93aqv 37 3 protein protein NN cord-355477-7xd93aqv 37 4 is be VBZ cord-355477-7xd93aqv 37 5 reportedly reportedly RB cord-355477-7xd93aqv 37 6 present present JJ cord-355477-7xd93aqv 37 7 in in IN cord-355477-7xd93aqv 37 8 type type NN cord-355477-7xd93aqv 37 9 1 1 CD cord-355477-7xd93aqv 37 10 and and CC cord-355477-7xd93aqv 37 11 type type NN cord-355477-7xd93aqv 37 12 2 2 CD cord-355477-7xd93aqv 37 13 pneumocytes pneumocyte NNS cord-355477-7xd93aqv 37 14 , , , cord-355477-7xd93aqv 37 15 enterocytes enterocyte NNS cord-355477-7xd93aqv 37 16 of of IN cord-355477-7xd93aqv 37 17 all all DT cord-355477-7xd93aqv 37 18 parts part NNS cord-355477-7xd93aqv 37 19 of of IN cord-355477-7xd93aqv 37 20 the the DT cord-355477-7xd93aqv 37 21 small small JJ cord-355477-7xd93aqv 37 22 intestine intestine NN cord-355477-7xd93aqv 37 23 , , , cord-355477-7xd93aqv 37 24 the the DT cord-355477-7xd93aqv 37 25 brush brush NN cord-355477-7xd93aqv 37 26 border border NN cord-355477-7xd93aqv 37 27 of of IN cord-355477-7xd93aqv 37 28 the the DT cord-355477-7xd93aqv 37 29 proximal proximal JJ cord-355477-7xd93aqv 37 30 tubular tubular JJ cord-355477-7xd93aqv 37 31 cells cell NNS cord-355477-7xd93aqv 37 32 of of IN cord-355477-7xd93aqv 37 33 the the DT cord-355477-7xd93aqv 37 34 kidney kidney NN cord-355477-7xd93aqv 37 35 as as RB cord-355477-7xd93aqv 37 36 well well RB cord-355477-7xd93aqv 37 37 as as IN cord-355477-7xd93aqv 37 38 the the DT cord-355477-7xd93aqv 37 39 endothelial endothelial JJ cord-355477-7xd93aqv 37 40 cells cell NNS cord-355477-7xd93aqv 37 41 of of IN cord-355477-7xd93aqv 37 42 small small JJ cord-355477-7xd93aqv 37 43 and and CC cord-355477-7xd93aqv 37 44 large large JJ cord-355477-7xd93aqv 37 45 arteries artery NNS cord-355477-7xd93aqv 37 46 and and CC cord-355477-7xd93aqv 37 47 veins vein NNS cord-355477-7xd93aqv 37 48 of of IN cord-355477-7xd93aqv 37 49 all all DT cord-355477-7xd93aqv 37 50 tissues tissue NNS cord-355477-7xd93aqv 37 51 studied study VBN cord-355477-7xd93aqv 37 52 , , , cord-355477-7xd93aqv 37 53 and and CC cord-355477-7xd93aqv 37 54 arterial arterial JJ cord-355477-7xd93aqv 37 55 smooth smooth JJ cord-355477-7xd93aqv 37 56 muscle muscle NN cord-355477-7xd93aqv 37 57 cells cell NNS cord-355477-7xd93aqv 37 58 . . . cord-355477-7xd93aqv 38 1 7 7 CD cord-355477-7xd93aqv 39 1 This this DT cord-355477-7xd93aqv 39 2 localization localization NN cord-355477-7xd93aqv 39 3 of of IN cord-355477-7xd93aqv 39 4 ACE2 ACE2 NNP cord-355477-7xd93aqv 39 5 explains explain VBZ cord-355477-7xd93aqv 39 6 the the DT cord-355477-7xd93aqv 39 7 tissue tissue NN cord-355477-7xd93aqv 39 8 tropism tropism NN cord-355477-7xd93aqv 39 9 of of IN cord-355477-7xd93aqv 39 10 SARS SARS NNP cord-355477-7xd93aqv 39 11 - - HYPH cord-355477-7xd93aqv 39 12 CoV CoV NNP cord-355477-7xd93aqv 39 13 for for IN cord-355477-7xd93aqv 39 14 the the DT cord-355477-7xd93aqv 39 15 lung lung NN cord-355477-7xd93aqv 39 16 , , , cord-355477-7xd93aqv 39 17 small small JJ cord-355477-7xd93aqv 39 18 intestine intestine NN cord-355477-7xd93aqv 39 19 , , , cord-355477-7xd93aqv 39 20 and and CC cord-355477-7xd93aqv 39 21 kidney kidney NN cord-355477-7xd93aqv 39 22 ; ; : cord-355477-7xd93aqv 39 23 however however RB cord-355477-7xd93aqv 39 24 , , , cord-355477-7xd93aqv 39 25 notable notable JJ cord-355477-7xd93aqv 39 26 discrepancies discrepancy NNS cord-355477-7xd93aqv 39 27 include include VBP cord-355477-7xd93aqv 39 28 virus virus NN cord-355477-7xd93aqv 39 29 replication replication NN cord-355477-7xd93aqv 39 30 in in IN cord-355477-7xd93aqv 39 31 colonic colonic JJ cord-355477-7xd93aqv 39 32 epithelium epithelium NN cord-355477-7xd93aqv 39 33 , , , cord-355477-7xd93aqv 39 34 which which WDT cord-355477-7xd93aqv 39 35 has have VBZ cord-355477-7xd93aqv 39 36 no no DT cord-355477-7xd93aqv 39 37 ACE2 ACE2 NNP cord-355477-7xd93aqv 39 38 , , , cord-355477-7xd93aqv 39 39 and and CC cord-355477-7xd93aqv 39 40 no no DT cord-355477-7xd93aqv 39 41 virus virus NN cord-355477-7xd93aqv 39 42 infection infection NN cord-355477-7xd93aqv 39 43 in in IN cord-355477-7xd93aqv 39 44 endothelial endothelial JJ cord-355477-7xd93aqv 39 45 cells cell NNS cord-355477-7xd93aqv 39 46 , , , cord-355477-7xd93aqv 39 47 which which WDT cord-355477-7xd93aqv 39 48 have have VBP cord-355477-7xd93aqv 39 49 ACE2 ACE2 NNP cord-355477-7xd93aqv 39 50 . . . cord-355477-7xd93aqv 40 1 Other other JJ cord-355477-7xd93aqv 40 2 receptors receptor NNS cord-355477-7xd93aqv 40 3 or or CC cord-355477-7xd93aqv 40 4 co co NNS cord-355477-7xd93aqv 40 5 - - NNS cord-355477-7xd93aqv 40 6 receptors receptor NNS cord-355477-7xd93aqv 40 7 such such JJ cord-355477-7xd93aqv 40 8 as as IN cord-355477-7xd93aqv 40 9 L l NN cord-355477-7xd93aqv 40 10 - - HYPH cord-355477-7xd93aqv 40 11 SIGN sign NN cord-355477-7xd93aqv 40 12 may may MD cord-355477-7xd93aqv 40 13 explain explain VB cord-355477-7xd93aqv 40 14 such such JJ cord-355477-7xd93aqv 40 15 discrepancies discrepancy NNS cord-355477-7xd93aqv 40 16 . . . cord-355477-7xd93aqv 41 1 The the DT cord-355477-7xd93aqv 41 2 SARS SARS NNP cord-355477-7xd93aqv 41 3 - - HYPH cord-355477-7xd93aqv 41 4 CoV CoV NNP cord-355477-7xd93aqv 41 5 genome genome NN cord-355477-7xd93aqv 41 6 has have VBZ cord-355477-7xd93aqv 41 7 been be VBN cord-355477-7xd93aqv 41 8 predicted predict VBN cord-355477-7xd93aqv 41 9 to to TO cord-355477-7xd93aqv 41 10 contain contain VB cord-355477-7xd93aqv 41 11 14 14 CD cord-355477-7xd93aqv 41 12 functional functional JJ cord-355477-7xd93aqv 41 13 open open JJ cord-355477-7xd93aqv 41 14 reading reading NN cord-355477-7xd93aqv 41 15 frames frame NNS cord-355477-7xd93aqv 41 16 ( ( -LRB- cord-355477-7xd93aqv 41 17 ORFs ORFs NNP cord-355477-7xd93aqv 41 18 ) ) -RRB- cord-355477-7xd93aqv 41 19 . . . cord-355477-7xd93aqv 42 1 The the DT cord-355477-7xd93aqv 42 2 comparison comparison NN cord-355477-7xd93aqv 42 3 of of IN cord-355477-7xd93aqv 42 4 different different JJ cord-355477-7xd93aqv 42 5 SARS SARS NNP cord-355477-7xd93aqv 42 6 - - HYPH cord-355477-7xd93aqv 42 7 CoV CoV NNP cord-355477-7xd93aqv 42 8 ORFs orfs NN cord-355477-7xd93aqv 42 9 with with IN cord-355477-7xd93aqv 42 10 those those DT cord-355477-7xd93aqv 42 11 of of IN cord-355477-7xd93aqv 42 12 other other JJ cord-355477-7xd93aqv 42 13 CoVs CoVs NNP cord-355477-7xd93aqv 42 14 revealed reveal VBD cord-355477-7xd93aqv 42 15 a a DT cord-355477-7xd93aqv 42 16 similar similar JJ cord-355477-7xd93aqv 42 17 pattern pattern NN cord-355477-7xd93aqv 42 18 of of IN cord-355477-7xd93aqv 42 19 structural structural JJ cord-355477-7xd93aqv 42 20 gene gene NN cord-355477-7xd93aqv 42 21 arrangement arrangement NN cord-355477-7xd93aqv 42 22 with with IN cord-355477-7xd93aqv 42 23 the the DT cord-355477-7xd93aqv 42 24 replicase replicase NN cord-355477-7xd93aqv 42 25 and and CC cord-355477-7xd93aqv 42 26 protease protease NN cord-355477-7xd93aqv 42 27 genes gene NNS cord-355477-7xd93aqv 42 28 ( ( -LRB- cord-355477-7xd93aqv 42 29 gene gene NN cord-355477-7xd93aqv 42 30 1a-1b 1a-1b CD cord-355477-7xd93aqv 42 31 ) ) -RRB- cord-355477-7xd93aqv 42 32 and and CC cord-355477-7xd93aqv 42 33 the the DT cord-355477-7xd93aqv 42 34 spike spike NN cord-355477-7xd93aqv 42 35 ( ( -LRB- cord-355477-7xd93aqv 42 36 S S NNP cord-355477-7xd93aqv 42 37 ) ) -RRB- cord-355477-7xd93aqv 42 38 , , , cord-355477-7xd93aqv 42 39 envelope envelope NN cord-355477-7xd93aqv 42 40 ( ( -LRB- cord-355477-7xd93aqv 42 41 E E NNP cord-355477-7xd93aqv 42 42 ) ) -RRB- cord-355477-7xd93aqv 42 43 , , , cord-355477-7xd93aqv 42 44 membrane membrane NN cord-355477-7xd93aqv 42 45 ( ( -LRB- cord-355477-7xd93aqv 42 46 M M NNP cord-355477-7xd93aqv 42 47 ) ) -RRB- cord-355477-7xd93aqv 42 48 , , , cord-355477-7xd93aqv 42 49 and and CC cord-355477-7xd93aqv 42 50 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 42 51 ( ( -LRB- cord-355477-7xd93aqv 42 52 N N NNP cord-355477-7xd93aqv 42 53 ) ) -RRB- cord-355477-7xd93aqv 42 54 genes gene NNS cord-355477-7xd93aqv 42 55 in in IN cord-355477-7xd93aqv 42 56 a a DT cord-355477-7xd93aqv 42 57 5 5 CD cord-355477-7xd93aqv 42 58 to to TO cord-355477-7xd93aqv 42 59 3 3 CD cord-355477-7xd93aqv 42 60 order order NN cord-355477-7xd93aqv 42 61 of of IN cord-355477-7xd93aqv 42 62 appearance appearance NN cord-355477-7xd93aqv 42 63 . . . cord-355477-7xd93aqv 43 1 Interspersed intersperse VBN cord-355477-7xd93aqv 43 2 between between IN cord-355477-7xd93aqv 43 3 these these DT cord-355477-7xd93aqv 43 4 well well RB cord-355477-7xd93aqv 43 5 - - HYPH cord-355477-7xd93aqv 43 6 characterized characterize VBN cord-355477-7xd93aqv 43 7 genes gene NNS cord-355477-7xd93aqv 43 8 is be VBZ cord-355477-7xd93aqv 43 9 a a DT cord-355477-7xd93aqv 43 10 series series NN cord-355477-7xd93aqv 43 11 of of IN cord-355477-7xd93aqv 43 12 ORFs ORFs NNP cord-355477-7xd93aqv 43 13 , , , cord-355477-7xd93aqv 43 14 many many JJ cord-355477-7xd93aqv 43 15 of of IN cord-355477-7xd93aqv 43 16 whose whose WP$ cord-355477-7xd93aqv 43 17 functions function NNS cord-355477-7xd93aqv 43 18 are be VBP cord-355477-7xd93aqv 43 19 yet yet RB cord-355477-7xd93aqv 43 20 unknown unknown JJ cord-355477-7xd93aqv 43 21 . . . cord-355477-7xd93aqv 44 1 There there EX cord-355477-7xd93aqv 44 2 are be VBP cord-355477-7xd93aqv 44 3 two two CD cord-355477-7xd93aqv 44 4 ORFs orf NNS cord-355477-7xd93aqv 44 5 situated situate VBN cord-355477-7xd93aqv 44 6 between between IN cord-355477-7xd93aqv 44 7 the the DT cord-355477-7xd93aqv 44 8 S S NNP cord-355477-7xd93aqv 44 9 and and CC cord-355477-7xd93aqv 44 10 the the DT cord-355477-7xd93aqv 44 11 E e NN cord-355477-7xd93aqv 44 12 genes gene NNS cord-355477-7xd93aqv 44 13 and and CC cord-355477-7xd93aqv 44 14 three three CD cord-355477-7xd93aqv 44 15 to to TO cord-355477-7xd93aqv 44 16 five five CD cord-355477-7xd93aqv 44 17 ORFs orf NNS cord-355477-7xd93aqv 44 18 between between IN cord-355477-7xd93aqv 44 19 the the DT cord-355477-7xd93aqv 44 20 M M NNP cord-355477-7xd93aqv 44 21 and and CC cord-355477-7xd93aqv 44 22 N n CD cord-355477-7xd93aqv 44 23 genes gene NNS cord-355477-7xd93aqv 44 24 ( ( -LRB- cord-355477-7xd93aqv 44 25 FIG.1 FIG.1 NNP cord-355477-7xd93aqv 44 26 ) ) -RRB- cord-355477-7xd93aqv 44 27 . . . cord-355477-7xd93aqv 45 1 Such such JJ cord-355477-7xd93aqv 45 2 gene gene NN cord-355477-7xd93aqv 45 3 organization organization NN cord-355477-7xd93aqv 45 4 most most RBS cord-355477-7xd93aqv 45 5 closely closely RB cord-355477-7xd93aqv 45 6 resembles resemble VBZ cord-355477-7xd93aqv 45 7 that that DT cord-355477-7xd93aqv 45 8 of of IN cord-355477-7xd93aqv 45 9 group group NN cord-355477-7xd93aqv 45 10 III iii CD cord-355477-7xd93aqv 45 11 CoVs CoVs NNP cord-355477-7xd93aqv 45 12 . . . cord-355477-7xd93aqv 46 1 Also also RB cord-355477-7xd93aqv 46 2 , , , cord-355477-7xd93aqv 46 3 the the DT cord-355477-7xd93aqv 46 4 SARS SARS NNP cord-355477-7xd93aqv 46 5 - - HYPH cord-355477-7xd93aqv 46 6 CoV CoV NNP cord-355477-7xd93aqv 46 7 genomic genomic JJ cord-355477-7xd93aqv 46 8 sequence sequence NN cord-355477-7xd93aqv 46 9 does do VBZ cord-355477-7xd93aqv 46 10 not not RB cord-355477-7xd93aqv 46 11 contain contain VB cord-355477-7xd93aqv 46 12 a a DT cord-355477-7xd93aqv 46 13 gene gene NN cord-355477-7xd93aqv 46 14 for for IN cord-355477-7xd93aqv 46 15 the the DT cord-355477-7xd93aqv 46 16 hemagglutinin hemagglutinin NN cord-355477-7xd93aqv 46 17 - - HYPH cord-355477-7xd93aqv 46 18 esterase esterase NN cord-355477-7xd93aqv 46 19 ( ( -LRB- cord-355477-7xd93aqv 46 20 HE he NN cord-355477-7xd93aqv 46 21 ) ) -RRB- cord-355477-7xd93aqv 46 22 protein protein NN cord-355477-7xd93aqv 46 23 , , , cord-355477-7xd93aqv 46 24 which which WDT cord-355477-7xd93aqv 46 25 is be VBZ cord-355477-7xd93aqv 46 26 present present JJ cord-355477-7xd93aqv 46 27 in in IN cord-355477-7xd93aqv 46 28 most most JJS cord-355477-7xd93aqv 46 29 group group NN cord-355477-7xd93aqv 46 30 II II NNP cord-355477-7xd93aqv 46 31 CoVs CoVs NNP cord-355477-7xd93aqv 46 32 . . . cord-355477-7xd93aqv 47 1 Two two CD cord-355477-7xd93aqv 47 2 - - HYPH cord-355477-7xd93aqv 47 3 thirds third NNS cord-355477-7xd93aqv 47 4 of of IN cord-355477-7xd93aqv 47 5 the the DT cord-355477-7xd93aqv 47 6 SARS SARS NNP cord-355477-7xd93aqv 47 7 - - HYPH cord-355477-7xd93aqv 47 8 CoV CoV NNP cord-355477-7xd93aqv 47 9 RNA RNA NNP cord-355477-7xd93aqv 47 10 is be VBZ cord-355477-7xd93aqv 47 11 organized organize VBN cord-355477-7xd93aqv 47 12 in in IN cord-355477-7xd93aqv 47 13 the the DT cord-355477-7xd93aqv 47 14 genes gene NNS cord-355477-7xd93aqv 47 15 1a-1b 1a-1b CD cord-355477-7xd93aqv 47 16 . . . cord-355477-7xd93aqv 48 1 The the DT cord-355477-7xd93aqv 48 2 sequence sequence NN cord-355477-7xd93aqv 48 3 of of IN cord-355477-7xd93aqv 48 4 these these DT cord-355477-7xd93aqv 48 5 genes gene NNS cord-355477-7xd93aqv 48 6 is be VBZ cord-355477-7xd93aqv 48 7 highly highly RB cord-355477-7xd93aqv 48 8 conserved conserve VBN cord-355477-7xd93aqv 48 9 among among IN cord-355477-7xd93aqv 48 10 all all DT cord-355477-7xd93aqv 48 11 CoVs CoVs NNP cord-355477-7xd93aqv 48 12 with with IN cord-355477-7xd93aqv 48 13 the the DT cord-355477-7xd93aqv 48 14 exception exception NN cord-355477-7xd93aqv 48 15 that that IN cord-355477-7xd93aqv 48 16 SARS SARS NNP cord-355477-7xd93aqv 48 17 - - HYPH cord-355477-7xd93aqv 48 18 CoV CoV NNP cord-355477-7xd93aqv 48 19 lacks lack VBZ cord-355477-7xd93aqv 48 20 the the DT cord-355477-7xd93aqv 48 21 sequence sequence NN cord-355477-7xd93aqv 48 22 coding code VBG cord-355477-7xd93aqv 48 23 for for IN cord-355477-7xd93aqv 48 24 papain papain NN cord-355477-7xd93aqv 48 25 - - HYPH cord-355477-7xd93aqv 48 26 like like JJ cord-355477-7xd93aqv 48 27 protease protease NN cord-355477-7xd93aqv 48 28 ( ( -LRB- cord-355477-7xd93aqv 48 29 PL1pro pl1pro ADD cord-355477-7xd93aqv 48 30 ) ) -RRB- cord-355477-7xd93aqv 48 31 , , , cord-355477-7xd93aqv 48 32 one one CD cord-355477-7xd93aqv 48 33 of of IN cord-355477-7xd93aqv 48 34 the the DT cord-355477-7xd93aqv 48 35 two two CD cord-355477-7xd93aqv 48 36 papain papain NN cord-355477-7xd93aqv 48 37 - - HYPH cord-355477-7xd93aqv 48 38 like like IN cord-355477-7xd93aqv 48 39 proteinases proteinase NNS cord-355477-7xd93aqv 48 40 operating operate VBG cord-355477-7xd93aqv 48 41 on on IN cord-355477-7xd93aqv 48 42 cleavage cleavage NN cord-355477-7xd93aqv 48 43 sites site NNS cord-355477-7xd93aqv 48 44 at at IN cord-355477-7xd93aqv 48 45 the the DT cord-355477-7xd93aqv 48 46 N n CD cord-355477-7xd93aqv 48 47 terminus terminus NN cord-355477-7xd93aqv 48 48 of of IN cord-355477-7xd93aqv 48 49 the the DT cord-355477-7xd93aqv 48 50 polyproteins polyprotein NNS cord-355477-7xd93aqv 48 51 . . . cord-355477-7xd93aqv 49 1 ORFs ORFs NNP cord-355477-7xd93aqv 49 2 1a 1a NN cord-355477-7xd93aqv 49 3 and and CC cord-355477-7xd93aqv 49 4 1b 1b CD cord-355477-7xd93aqv 49 5 encode encode VB cord-355477-7xd93aqv 49 6 two two CD cord-355477-7xd93aqv 49 7 polyproteins polyprotein NNS cord-355477-7xd93aqv 49 8 , , , cord-355477-7xd93aqv 49 9 pp1a pp1a NNP cord-355477-7xd93aqv 49 10 and and CC cord-355477-7xd93aqv 49 11 pp1ab pp1ab NNP cord-355477-7xd93aqv 49 12 , , , cord-355477-7xd93aqv 49 13 the the DT cord-355477-7xd93aqv 49 14 latter latter NN cord-355477-7xd93aqv 49 15 is be VBZ cord-355477-7xd93aqv 49 16 predicted predict VBN cord-355477-7xd93aqv 49 17 to to TO cord-355477-7xd93aqv 49 18 translate translate VB cord-355477-7xd93aqv 49 19 through through IN cord-355477-7xd93aqv 49 20 a a DT cord-355477-7xd93aqv 49 21 -1 -1 NN cord-355477-7xd93aqv 49 22 ribosomal ribosomal JJ cord-355477-7xd93aqv 49 23 frameshifting frameshifting NN cord-355477-7xd93aqv 49 24 mechanism mechanism NN cord-355477-7xd93aqv 49 25 . . . cord-355477-7xd93aqv 50 1 These these DT cord-355477-7xd93aqv 50 2 two two CD cord-355477-7xd93aqv 50 3 polyproteins polyprotein NNS cord-355477-7xd93aqv 50 4 are be VBP cord-355477-7xd93aqv 50 5 processed process VBN cord-355477-7xd93aqv 50 6 by by IN cord-355477-7xd93aqv 50 7 virus virus NN cord-355477-7xd93aqv 50 8 - - HYPH cord-355477-7xd93aqv 50 9 encoded encode VBN cord-355477-7xd93aqv 50 10 proteinases proteinase NNS cord-355477-7xd93aqv 50 11 , , , cord-355477-7xd93aqv 50 12 to to TO cord-355477-7xd93aqv 50 13 yield yield VB cord-355477-7xd93aqv 50 14 16 16 CD cord-355477-7xd93aqv 50 15 individual individual JJ cord-355477-7xd93aqv 50 16 nonstructural nonstructural JJ cord-355477-7xd93aqv 50 17 proteins protein NNS cord-355477-7xd93aqv 50 18 ( ( -LRB- cord-355477-7xd93aqv 50 19 nsp nsp NN cord-355477-7xd93aqv 50 20 ) ) -RRB- cord-355477-7xd93aqv 50 21 . . . cord-355477-7xd93aqv 51 1 Many many JJ cord-355477-7xd93aqv 51 2 of of IN cord-355477-7xd93aqv 51 3 the the DT cord-355477-7xd93aqv 51 4 postulated postulate VBN cord-355477-7xd93aqv 51 5 nsp nsp NN cord-355477-7xd93aqv 51 6 proteins protein NNS cord-355477-7xd93aqv 51 7 to to IN cord-355477-7xd93aqv 51 8 date date NN cord-355477-7xd93aqv 51 9 have have VBP cord-355477-7xd93aqv 51 10 undesignated undesignated JJ cord-355477-7xd93aqv 51 11 functions function NNS cord-355477-7xd93aqv 51 12 but but CC cord-355477-7xd93aqv 51 13 it -PRON- PRP cord-355477-7xd93aqv 51 14 is be VBZ cord-355477-7xd93aqv 51 15 suggested suggest VBN cord-355477-7xd93aqv 51 16 that that IN cord-355477-7xd93aqv 51 17 they -PRON- PRP cord-355477-7xd93aqv 51 18 participate participate VBP cord-355477-7xd93aqv 51 19 primarily primarily RB cord-355477-7xd93aqv 51 20 in in IN cord-355477-7xd93aqv 51 21 viral viral JJ cord-355477-7xd93aqv 51 22 RNA RNA NNP cord-355477-7xd93aqv 51 23 replication replication NN cord-355477-7xd93aqv 51 24 . . . cord-355477-7xd93aqv 52 1 Most Most JJS cord-355477-7xd93aqv 52 2 potential potential JJ cord-355477-7xd93aqv 52 3 gene gene NN cord-355477-7xd93aqv 52 4 1a-1b 1a-1b CD cord-355477-7xd93aqv 52 5 products product NNS cord-355477-7xd93aqv 52 6 are be VBP cord-355477-7xd93aqv 52 7 fairly fairly RB cord-355477-7xd93aqv 52 8 well well RB cord-355477-7xd93aqv 52 9 conserved conserve VBN cord-355477-7xd93aqv 52 10 between between IN cord-355477-7xd93aqv 52 11 SARS SARS NNP cord-355477-7xd93aqv 52 12 - - HYPH cord-355477-7xd93aqv 52 13 CoV CoV NNP cord-355477-7xd93aqv 52 14 and and CC cord-355477-7xd93aqv 52 15 other other JJ cord-355477-7xd93aqv 52 16 CoVs CoVs NNP cord-355477-7xd93aqv 52 17 . . . cord-355477-7xd93aqv 53 1 PL2pro PL2pro NNP cord-355477-7xd93aqv 53 2 of of IN cord-355477-7xd93aqv 53 3 the the DT cord-355477-7xd93aqv 53 4 SARS SARS NNP cord-355477-7xd93aqv 53 5 virus virus NN cord-355477-7xd93aqv 53 6 is be VBZ cord-355477-7xd93aqv 53 7 responsible responsible JJ cord-355477-7xd93aqv 53 8 for for IN cord-355477-7xd93aqv 53 9 the the DT cord-355477-7xd93aqv 53 10 cleavage cleavage NN cord-355477-7xd93aqv 53 11 of of IN cord-355477-7xd93aqv 53 12 all all PDT cord-355477-7xd93aqv 53 13 the the DT cord-355477-7xd93aqv 53 14 N n CD cord-355477-7xd93aqv 53 15 - - HYPH cord-355477-7xd93aqv 53 16 terminal terminal NN cord-355477-7xd93aqv 53 17 proteins protein NNS cord-355477-7xd93aqv 53 18 of of IN cord-355477-7xd93aqv 53 19 gene gene NN cord-355477-7xd93aqv 53 20 1a 1a CD cord-355477-7xd93aqv 53 21 . . . cord-355477-7xd93aqv 54 1 The the DT cord-355477-7xd93aqv 54 2 main main JJ cord-355477-7xd93aqv 54 3 proteinase proteinase NN cord-355477-7xd93aqv 54 4 ( ( -LRB- cord-355477-7xd93aqv 54 5 Mpro Mpro NNP cord-355477-7xd93aqv 54 6 ) ) -RRB- cord-355477-7xd93aqv 54 7 , , , cord-355477-7xd93aqv 54 8 also also RB cord-355477-7xd93aqv 54 9 called call VBD cord-355477-7xd93aqv 54 10 the the DT cord-355477-7xd93aqv 54 11 3C 3c NN cord-355477-7xd93aqv 54 12 - - HYPH cord-355477-7xd93aqv 54 13 like like JJ cord-355477-7xd93aqv 54 14 protease protease NN cord-355477-7xd93aqv 54 15 ( ( -LRB- cord-355477-7xd93aqv 54 16 3CLpro 3clpro CD cord-355477-7xd93aqv 54 17 ) ) -RRB- cord-355477-7xd93aqv 54 18 , , , cord-355477-7xd93aqv 54 19 is be VBZ cord-355477-7xd93aqv 54 20 responsible responsible JJ cord-355477-7xd93aqv 54 21 for for IN cord-355477-7xd93aqv 54 22 the the DT cord-355477-7xd93aqv 54 23 cleavage cleavage NN cord-355477-7xd93aqv 54 24 of of IN cord-355477-7xd93aqv 54 25 all all PDT cord-355477-7xd93aqv 54 26 the the DT cord-355477-7xd93aqv 54 27 remaining remain VBG cord-355477-7xd93aqv 54 28 proteins protein NNS cord-355477-7xd93aqv 54 29 encoded encode VBN cord-355477-7xd93aqv 54 30 by by IN cord-355477-7xd93aqv 54 31 gene gene NN cord-355477-7xd93aqv 54 32 1a-1b 1a-1b CD cord-355477-7xd93aqv 54 33 . . . cord-355477-7xd93aqv 55 1 The the DT cord-355477-7xd93aqv 55 2 5 5 CD cord-355477-7xd93aqv 55 3 UTR UTR NNP cord-355477-7xd93aqv 55 4 ( ( -LRB- cord-355477-7xd93aqv 55 5 untranslated untranslated JJ cord-355477-7xd93aqv 55 6 region region NN cord-355477-7xd93aqv 55 7 ) ) -RRB- cord-355477-7xd93aqv 55 8 of of IN cord-355477-7xd93aqv 55 9 the the DT cord-355477-7xd93aqv 55 10 SARS SARS NNP cord-355477-7xd93aqv 55 11 - - HYPH cord-355477-7xd93aqv 55 12 CoV CoV NNP cord-355477-7xd93aqv 55 13 genome genome NN cord-355477-7xd93aqv 55 14 was be VBD cord-355477-7xd93aqv 55 15 initially initially RB cord-355477-7xd93aqv 55 16 characterized characterize VBN cord-355477-7xd93aqv 55 17 by by IN cord-355477-7xd93aqv 55 18 5 5 CD cord-355477-7xd93aqv 55 19 rapid rapid JJ cord-355477-7xd93aqv 55 20 amplification amplification NN cord-355477-7xd93aqv 55 21 of of IN cord-355477-7xd93aqv 55 22 the the DT cord-355477-7xd93aqv 55 23 cDNA cdna NN cord-355477-7xd93aqv 55 24 ends end VBZ cord-355477-7xd93aqv 55 25 and and CC cord-355477-7xd93aqv 55 26 Northern northern JJ cord-355477-7xd93aqv 55 27 blot blot NN cord-355477-7xd93aqv 55 28 assays assay NNS cord-355477-7xd93aqv 55 29 . . . cord-355477-7xd93aqv 56 1 These these DT cord-355477-7xd93aqv 56 2 procedures procedure NNS cord-355477-7xd93aqv 56 3 elucidated elucidate VBD cord-355477-7xd93aqv 56 4 the the DT cord-355477-7xd93aqv 56 5 leader leader NN cord-355477-7xd93aqv 56 6 sequence sequence NN cord-355477-7xd93aqv 56 7 and and CC cord-355477-7xd93aqv 56 8 the the DT cord-355477-7xd93aqv 56 9 transcription transcription NN cord-355477-7xd93aqv 56 10 regulatory regulatory JJ cord-355477-7xd93aqv 56 11 sequence sequence NN cord-355477-7xd93aqv 56 12 ( ( -LRB- cord-355477-7xd93aqv 56 13 TRS TRS NNP cord-355477-7xd93aqv 56 14 ) ) -RRB- cord-355477-7xd93aqv 56 15 . . . cord-355477-7xd93aqv 57 1 The the DT cord-355477-7xd93aqv 57 2 leader leader NN cord-355477-7xd93aqv 57 3 sequences sequence NNS cord-355477-7xd93aqv 57 4 found find VBD cord-355477-7xd93aqv 57 5 in in IN cord-355477-7xd93aqv 57 6 the the DT cord-355477-7xd93aqv 57 7 viral viral JJ cord-355477-7xd93aqv 57 8 sg sg NNP cord-355477-7xd93aqv 57 9 - - HYPH cord-355477-7xd93aqv 57 10 mRNA mRNA NNP cord-355477-7xd93aqv 57 11 ( ( -LRB- cord-355477-7xd93aqv 57 12 subgenomic subgenomic NNP cord-355477-7xd93aqv 57 13 - - HYPH cord-355477-7xd93aqv 57 14 mRNA mrna NN cord-355477-7xd93aqv 57 15 ) ) -RRB- cord-355477-7xd93aqv 57 16 transcripts transcript NNS cord-355477-7xd93aqv 57 17 were be VBD cord-355477-7xd93aqv 57 18 at at RB cord-355477-7xd93aqv 57 19 least least RBS cord-355477-7xd93aqv 57 20 72 72 CD cord-355477-7xd93aqv 57 21 nucleotides nucleotide NNS cord-355477-7xd93aqv 57 22 long long JJ cord-355477-7xd93aqv 57 23 . . . cord-355477-7xd93aqv 58 1 After after IN cord-355477-7xd93aqv 58 2 aligning align VBG cord-355477-7xd93aqv 58 3 the the DT cord-355477-7xd93aqv 58 4 leader leader NN cord-355477-7xd93aqv 58 5 sequence sequence NN cord-355477-7xd93aqv 58 6 at at IN cord-355477-7xd93aqv 58 7 the the DT cord-355477-7xd93aqv 58 8 5 5 CD cord-355477-7xd93aqv 58 9 end end NN cord-355477-7xd93aqv 58 10 of of IN cord-355477-7xd93aqv 58 11 the the DT cord-355477-7xd93aqv 58 12 eight eight CD cord-355477-7xd93aqv 58 13 sg sg NN cord-355477-7xd93aqv 58 14 - - HYPH cord-355477-7xd93aqv 58 15 mRNAs mRNAs NNP cord-355477-7xd93aqv 58 16 , , , cord-355477-7xd93aqv 58 17 a a DT cord-355477-7xd93aqv 58 18 minimal minimal JJ cord-355477-7xd93aqv 58 19 consensus consensus NN cord-355477-7xd93aqv 58 20 TRS TRS NNP cord-355477-7xd93aqv 58 21 was be VBD cord-355477-7xd93aqv 58 22 found find VBN cord-355477-7xd93aqv 58 23 with with IN cord-355477-7xd93aqv 58 24 the the DT cord-355477-7xd93aqv 58 25 sequence sequence NN cord-355477-7xd93aqv 58 26 5 5 CD cord-355477-7xd93aqv 58 27 -ACGAAC-3 -ACGAAC-3 NNP cord-355477-7xd93aqv 58 28 , , , cord-355477-7xd93aqv 58 29 8 8 CD cord-355477-7xd93aqv 58 30 which which WDT cord-355477-7xd93aqv 58 31 participated participate VBD cord-355477-7xd93aqv 58 32 in in IN cord-355477-7xd93aqv 58 33 the the DT cord-355477-7xd93aqv 58 34 discontinuous discontinuous JJ cord-355477-7xd93aqv 58 35 synthesis synthesis NN cord-355477-7xd93aqv 58 36 of of IN cord-355477-7xd93aqv 58 37 sg sg NNP cord-355477-7xd93aqv 58 38 - - : cord-355477-7xd93aqv 58 39 mRNAs mRNAs NNP cord-355477-7xd93aqv 58 40 as as IN cord-355477-7xd93aqv 58 41 a a DT cord-355477-7xd93aqv 58 42 signaling signal VBG cord-355477-7xd93aqv 58 43 sequence sequence NN cord-355477-7xd93aqv 58 44 . . . cord-355477-7xd93aqv 59 1 TRS TRS NNP cord-355477-7xd93aqv 59 2 showed show VBD cord-355477-7xd93aqv 59 3 no no DT cord-355477-7xd93aqv 59 4 clear clear JJ cord-355477-7xd93aqv 59 5 relationship relationship NN cord-355477-7xd93aqv 59 6 with with IN cord-355477-7xd93aqv 59 7 the the DT cord-355477-7xd93aqv 59 8 abundance abundance NN cord-355477-7xd93aqv 59 9 of of IN cord-355477-7xd93aqv 59 10 the the DT cord-355477-7xd93aqv 59 11 sg sg NN cord-355477-7xd93aqv 59 12 - - HYPH cord-355477-7xd93aqv 59 13 mRNAs mRNAs NNP cord-355477-7xd93aqv 59 14 . . . cord-355477-7xd93aqv 60 1 A a DT cord-355477-7xd93aqv 60 2 highly highly RB cord-355477-7xd93aqv 60 3 conserved conserve VBN cord-355477-7xd93aqv 60 4 s2 s2 NN cord-355477-7xd93aqv 60 5 m m NN cord-355477-7xd93aqv 60 6 motif motif NN cord-355477-7xd93aqv 60 7 with with IN cord-355477-7xd93aqv 60 8 32 32 CD cord-355477-7xd93aqv 60 9 nucleotides nucleotide NNS cord-355477-7xd93aqv 60 10 was be VBD cord-355477-7xd93aqv 60 11 also also RB cord-355477-7xd93aqv 60 12 identified identify VBN cord-355477-7xd93aqv 60 13 in in IN cord-355477-7xd93aqv 60 14 the the DT cord-355477-7xd93aqv 60 15 3 3 CD cord-355477-7xd93aqv 60 16 region region NN cord-355477-7xd93aqv 60 17 of of IN cord-355477-7xd93aqv 60 18 the the DT cord-355477-7xd93aqv 60 19 genome genome NN cord-355477-7xd93aqv 60 20 , , , cord-355477-7xd93aqv 60 21 which which WDT cord-355477-7xd93aqv 60 22 has have VBZ cord-355477-7xd93aqv 60 23 also also RB cord-355477-7xd93aqv 60 24 been be VBN cord-355477-7xd93aqv 60 25 discovered discover VBN cord-355477-7xd93aqv 60 26 in in IN cord-355477-7xd93aqv 60 27 the the DT cord-355477-7xd93aqv 60 28 avian avian JJ cord-355477-7xd93aqv 60 29 infectious infectious JJ cord-355477-7xd93aqv 60 30 bronchitis bronchitis NN cord-355477-7xd93aqv 60 31 virus virus NN cord-355477-7xd93aqv 60 32 . . . cord-355477-7xd93aqv 61 1 The the DT cord-355477-7xd93aqv 61 2 replicase replicase NN cord-355477-7xd93aqv 61 3 gene gene NN cord-355477-7xd93aqv 61 4 of of IN cord-355477-7xd93aqv 61 5 the the DT cord-355477-7xd93aqv 61 6 SARS SARS NNP cord-355477-7xd93aqv 61 7 - - HYPH cord-355477-7xd93aqv 61 8 CoV CoV NNP cord-355477-7xd93aqv 61 9 encodes encode VBZ cord-355477-7xd93aqv 61 10 for for IN cord-355477-7xd93aqv 61 11 two two CD cord-355477-7xd93aqv 61 12 proteins protein NNS cord-355477-7xd93aqv 61 13 as as IN cord-355477-7xd93aqv 61 14 a a DT cord-355477-7xd93aqv 61 15 consequence consequence NN cord-355477-7xd93aqv 61 16 of of IN cord-355477-7xd93aqv 61 17 the the DT cord-355477-7xd93aqv 61 18 proteolytic proteolytic JJ cord-355477-7xd93aqv 61 19 processing processing NN cord-355477-7xd93aqv 61 20 of of IN cord-355477-7xd93aqv 61 21 the the DT cord-355477-7xd93aqv 61 22 large large JJ cord-355477-7xd93aqv 61 23 polyproteins polyprotein NNS cord-355477-7xd93aqv 61 24 ( ( -LRB- cord-355477-7xd93aqv 61 25 pp1a pp1a NNP cord-355477-7xd93aqv 61 26 and and CC cord-355477-7xd93aqv 61 27 pp1ab pp1ab NNP cord-355477-7xd93aqv 61 28 ) ) -RRB- cord-355477-7xd93aqv 61 29 . . . cord-355477-7xd93aqv 62 1 The the DT cord-355477-7xd93aqv 62 2 translation translation NN cord-355477-7xd93aqv 62 3 of of IN cord-355477-7xd93aqv 62 4 segment segment NN cord-355477-7xd93aqv 62 5 1b 1b CD cord-355477-7xd93aqv 62 6 of of IN cord-355477-7xd93aqv 62 7 such such PDT cord-355477-7xd93aqv 62 8 a a DT cord-355477-7xd93aqv 62 9 polyprotein polyprotein NN cord-355477-7xd93aqv 62 10 is be VBZ cord-355477-7xd93aqv 62 11 interrupted interrupt VBN cord-355477-7xd93aqv 62 12 by by IN cord-355477-7xd93aqv 62 13 the the DT cord-355477-7xd93aqv 62 14 -1 -1 NN cord-355477-7xd93aqv 62 15 ribosomal ribosomal JJ cord-355477-7xd93aqv 62 16 frameshifting frameshifte VBG cord-355477-7xd93aqv 62 17 by by IN cord-355477-7xd93aqv 62 18 a a DT cord-355477-7xd93aqv 62 19 putative putative JJ cord-355477-7xd93aqv 62 20 " " `` cord-355477-7xd93aqv 62 21 slippery slippery JJ cord-355477-7xd93aqv 62 22 " " '' cord-355477-7xd93aqv 62 23 sequence sequence NN cord-355477-7xd93aqv 62 24 and and CC cord-355477-7xd93aqv 62 25 a a DT cord-355477-7xd93aqv 62 26 corresponding correspond VBG cord-355477-7xd93aqv 62 27 putative putative JJ cord-355477-7xd93aqv 62 28 pseudoknot pseudoknot NN cord-355477-7xd93aqv 62 29 structure structure NN cord-355477-7xd93aqv 62 30 , , , cord-355477-7xd93aqv 62 31 which which WDT cord-355477-7xd93aqv 62 32 is be VBZ cord-355477-7xd93aqv 62 33 required require VBN cord-355477-7xd93aqv 62 34 for for IN cord-355477-7xd93aqv 62 35 stalling stall VBG cord-355477-7xd93aqv 62 36 the the DT cord-355477-7xd93aqv 62 37 translating translate VBG cord-355477-7xd93aqv 62 38 ribosome ribosome NN cord-355477-7xd93aqv 62 39 at at IN cord-355477-7xd93aqv 62 40 the the DT cord-355477-7xd93aqv 62 41 slippery slippery JJ cord-355477-7xd93aqv 62 42 site site NN cord-355477-7xd93aqv 62 43 to to TO cord-355477-7xd93aqv 62 44 undergo undergo VB cord-355477-7xd93aqv 62 45 -1 -1 NNP cord-355477-7xd93aqv 62 46 translational translational JJ cord-355477-7xd93aqv 62 47 frameshifting frameshifting NN cord-355477-7xd93aqv 62 48 . . . cord-355477-7xd93aqv 63 1 Two two CD cord-355477-7xd93aqv 63 2 functional functional JJ cord-355477-7xd93aqv 63 3 domains domain NNS cord-355477-7xd93aqv 63 4 , , , cord-355477-7xd93aqv 63 5 the the DT cord-355477-7xd93aqv 63 6 papain papain NN cord-355477-7xd93aqv 63 7 - - HYPH cord-355477-7xd93aqv 63 8 like like JJ cord-355477-7xd93aqv 63 9 cysteine cysteine NN cord-355477-7xd93aqv 63 10 proteinase proteinase NN cord-355477-7xd93aqv 63 11 ( ( -LRB- cord-355477-7xd93aqv 63 12 PL2pro pl2pro ADD cord-355477-7xd93aqv 63 13 ) ) -RRB- cord-355477-7xd93aqv 63 14 and and CC cord-355477-7xd93aqv 63 15 the the DT cord-355477-7xd93aqv 63 16 3C 3c NN cord-355477-7xd93aqv 63 17 - - HYPH cord-355477-7xd93aqv 63 18 like like JJ cord-355477-7xd93aqv 63 19 cysteine cysteine NN cord-355477-7xd93aqv 63 20 proteinase proteinase NN cord-355477-7xd93aqv 63 21 ( ( -LRB- cord-355477-7xd93aqv 63 22 3CLpro 3clpro CD cord-355477-7xd93aqv 63 23 ) ) -RRB- cord-355477-7xd93aqv 63 24 , , , cord-355477-7xd93aqv 63 25 were be VBD cord-355477-7xd93aqv 63 26 identified identify VBN cord-355477-7xd93aqv 63 27 experimentally experimentally RB cord-355477-7xd93aqv 63 28 and and CC cord-355477-7xd93aqv 63 29 are be VBP cord-355477-7xd93aqv 63 30 considered consider VBN cord-355477-7xd93aqv 63 31 responsible responsible JJ cord-355477-7xd93aqv 63 32 for for IN cord-355477-7xd93aqv 63 33 the the DT cord-355477-7xd93aqv 63 34 proteolytic proteolytic JJ cord-355477-7xd93aqv 63 35 processing processing NN cord-355477-7xd93aqv 63 36 of of IN cord-355477-7xd93aqv 63 37 the the DT cord-355477-7xd93aqv 63 38 polyprotein polyprotein NN cord-355477-7xd93aqv 63 39 into into IN cord-355477-7xd93aqv 63 40 16 16 CD cord-355477-7xd93aqv 63 41 subunits subunit NNS cord-355477-7xd93aqv 63 42 . . . cord-355477-7xd93aqv 64 1 A a DT cord-355477-7xd93aqv 64 2 375 375 CD cord-355477-7xd93aqv 64 3 amino amino NN cord-355477-7xd93aqv 64 4 acid acid NN cord-355477-7xd93aqv 64 5 SARS SARS NNP cord-355477-7xd93aqv 64 6 - - HYPH cord-355477-7xd93aqv 64 7 CoV CoV NNP cord-355477-7xd93aqv 64 8 unique unique JJ cord-355477-7xd93aqv 64 9 domain domain NN cord-355477-7xd93aqv 64 10 was be VBD cord-355477-7xd93aqv 64 11 identified identify VBN cord-355477-7xd93aqv 64 12 upstream upstream RB cord-355477-7xd93aqv 64 13 of of IN cord-355477-7xd93aqv 64 14 the the DT cord-355477-7xd93aqv 64 15 PL2pro PL2pro NNP cord-355477-7xd93aqv 64 16 domain domain NN cord-355477-7xd93aqv 64 17 , , , cord-355477-7xd93aqv 64 18 not not RB cord-355477-7xd93aqv 64 19 found find VBN cord-355477-7xd93aqv 64 20 in in IN cord-355477-7xd93aqv 64 21 any any DT cord-355477-7xd93aqv 64 22 other other JJ cord-355477-7xd93aqv 64 23 known know VBN cord-355477-7xd93aqv 64 24 CoVs CoVs NNP cord-355477-7xd93aqv 64 25 . . . cord-355477-7xd93aqv 65 1 In in IN cord-355477-7xd93aqv 65 2 addition addition NN cord-355477-7xd93aqv 65 3 , , , cord-355477-7xd93aqv 65 4 seven seven CD cord-355477-7xd93aqv 65 5 more more JJR cord-355477-7xd93aqv 65 6 putative putative JJ cord-355477-7xd93aqv 65 7 regions region NNS cord-355477-7xd93aqv 65 8 encoding encode VBG cord-355477-7xd93aqv 65 9 RNA rna NN cord-355477-7xd93aqv 65 10 processing processing NN cord-355477-7xd93aqv 65 11 enzymes enzyme NNS cord-355477-7xd93aqv 65 12 were be VBD cord-355477-7xd93aqv 65 13 identified identify VBN cord-355477-7xd93aqv 65 14 , , , cord-355477-7xd93aqv 65 15 namely namely RB cord-355477-7xd93aqv 65 16 , , , cord-355477-7xd93aqv 65 17 RNA RNA NNP cord-355477-7xd93aqv 65 18 - - HYPH cord-355477-7xd93aqv 65 19 dependent dependent JJ cord-355477-7xd93aqv 65 20 RNA RNA NNP cord-355477-7xd93aqv 65 21 polymerase polymerase NN cord-355477-7xd93aqv 65 22 ( ( -LRB- cord-355477-7xd93aqv 65 23 RDRP RDRP NNP cord-355477-7xd93aqv 65 24 ) ) -RRB- cord-355477-7xd93aqv 65 25 , , , cord-355477-7xd93aqv 65 26 RNA RNA NNP cord-355477-7xd93aqv 65 27 helicase helicase NN cord-355477-7xd93aqv 65 28 ( ( -LRB- cord-355477-7xd93aqv 65 29 HEL HEL NNP cord-355477-7xd93aqv 65 30 ) ) -RRB- cord-355477-7xd93aqv 65 31 , , , cord-355477-7xd93aqv 65 32 poly poly NNP cord-355477-7xd93aqv 65 33 ( ( -LRB- cord-355477-7xd93aqv 65 34 U)-specific U)-specific NNP cord-355477-7xd93aqv 65 35 endoribonuclease endoribonuclease NN cord-355477-7xd93aqv 65 36 ( ( -LRB- cord-355477-7xd93aqv 65 37 NendoU NendoU NNP cord-355477-7xd93aqv 65 38 ) ) -RRB- cord-355477-7xd93aqv 65 39 , , , cord-355477-7xd93aqv 65 40 3 3 CD cord-355477-7xd93aqv 65 41 -5 -5 CD cord-355477-7xd93aqv 65 42 exonuclease exonuclease NN cord-355477-7xd93aqv 65 43 ( ( -LRB- cord-355477-7xd93aqv 65 44 ExoN ExoN NNP cord-355477-7xd93aqv 65 45 ) ) -RRB- cord-355477-7xd93aqv 65 46 , , , cord-355477-7xd93aqv 65 47 S s NN cord-355477-7xd93aqv 65 48 - - HYPH cord-355477-7xd93aqv 65 49 adenosylmethionine adenosylmethionine NN cord-355477-7xd93aqv 65 50 - - HYPH cord-355477-7xd93aqv 65 51 dependent dependent JJ cord-355477-7xd93aqv 65 52 ribose ribose NN cord-355477-7xd93aqv 65 53 2 2 CD cord-355477-7xd93aqv 65 54 -O -O : cord-355477-7xd93aqv 65 55 - - HYPH cord-355477-7xd93aqv 65 56 methyltransferase methyltransferase NN cord-355477-7xd93aqv 65 57 ( ( -LRB- cord-355477-7xd93aqv 65 58 2 2 CD cord-355477-7xd93aqv 65 59 -O -o CD cord-355477-7xd93aqv 65 60 - - HYPH cord-355477-7xd93aqv 65 61 MT MT NNP cord-355477-7xd93aqv 65 62 ) ) -RRB- cord-355477-7xd93aqv 65 63 , , , cord-355477-7xd93aqv 65 64 adenosine adenosine NN cord-355477-7xd93aqv 65 65 diphosphate diphosphate NN cord-355477-7xd93aqv 65 66 - - HYPH cord-355477-7xd93aqv 65 67 ribose ribose NN cord-355477-7xd93aqv 65 68 1 1 CD cord-355477-7xd93aqv 65 69 -phosphatase -phosphatase CD cord-355477-7xd93aqv 65 70 ( ( -LRB- cord-355477-7xd93aqv 65 71 ADRP ADRP NNP cord-355477-7xd93aqv 65 72 ) ) -RRB- cord-355477-7xd93aqv 65 73 , , , cord-355477-7xd93aqv 65 74 and and CC cord-355477-7xd93aqv 65 75 a a DT cord-355477-7xd93aqv 65 76 cyclic cyclic JJ cord-355477-7xd93aqv 65 77 phosphodiesterase phosphodiesterase NN cord-355477-7xd93aqv 65 78 ( ( -LRB- cord-355477-7xd93aqv 65 79 CPD CPD NNP cord-355477-7xd93aqv 65 80 ) ) -RRB- cord-355477-7xd93aqv 65 81 . . . cord-355477-7xd93aqv 66 1 The the DT cord-355477-7xd93aqv 66 2 translation translation NN cord-355477-7xd93aqv 66 3 of of IN cord-355477-7xd93aqv 66 4 two two CD cord-355477-7xd93aqv 66 5 polyproteins polyprotein NNS cord-355477-7xd93aqv 66 6 from from IN cord-355477-7xd93aqv 66 7 the the DT cord-355477-7xd93aqv 66 8 ORF ORF NNP cord-355477-7xd93aqv 66 9 1a 1a NN cord-355477-7xd93aqv 66 10 and and CC cord-355477-7xd93aqv 66 11 1b 1b NN cord-355477-7xd93aqv 66 12 starts start VBZ cord-355477-7xd93aqv 66 13 the the DT cord-355477-7xd93aqv 66 14 genome genome NN cord-355477-7xd93aqv 66 15 expression expression NN cord-355477-7xd93aqv 66 16 ( ( -LRB- cord-355477-7xd93aqv 66 17 FIG fig NN cord-355477-7xd93aqv 66 18 . . . cord-355477-7xd93aqv 66 19 1 1 CD cord-355477-7xd93aqv 66 20 ) ) -RRB- cord-355477-7xd93aqv 66 21 . . . cord-355477-7xd93aqv 67 1 The the DT cord-355477-7xd93aqv 67 2 polyproteins polyprotein NNS cord-355477-7xd93aqv 67 3 are be VBP cord-355477-7xd93aqv 67 4 then then RB cord-355477-7xd93aqv 67 5 proteolytically proteolytically RB cord-355477-7xd93aqv 67 6 processed process VBN cord-355477-7xd93aqv 67 7 by by IN cord-355477-7xd93aqv 67 8 PL2pro PL2pro NNS cord-355477-7xd93aqv 67 9 and and CC cord-355477-7xd93aqv 67 10 3CLpro 3clpro CD cord-355477-7xd93aqv 67 11 into into IN cord-355477-7xd93aqv 67 12 16 16 CD cord-355477-7xd93aqv 67 13 units unit NNS cord-355477-7xd93aqv 67 14 . . . cord-355477-7xd93aqv 68 1 PL2pro PL2pro NNP cord-355477-7xd93aqv 68 2 is be VBZ cord-355477-7xd93aqv 68 3 responsible responsible JJ cord-355477-7xd93aqv 68 4 for for IN cord-355477-7xd93aqv 68 5 the the DT cord-355477-7xd93aqv 68 6 N n NN cord-355477-7xd93aqv 68 7 - - HYPH cord-355477-7xd93aqv 68 8 proximal proximal JJ cord-355477-7xd93aqv 68 9 cleavage cleavage NN cord-355477-7xd93aqv 68 10 and and CC cord-355477-7xd93aqv 68 11 3CLpro 3clpro CD cord-355477-7xd93aqv 68 12 is be VBZ cord-355477-7xd93aqv 68 13 responsible responsible JJ cord-355477-7xd93aqv 68 14 for for IN cord-355477-7xd93aqv 68 15 the the DT cord-355477-7xd93aqv 68 16 C C NNP cord-355477-7xd93aqv 68 17 - - HYPH cord-355477-7xd93aqv 68 18 proximal proximal JJ cord-355477-7xd93aqv 68 19 cleavage cleavage NN cord-355477-7xd93aqv 68 20 . . . cord-355477-7xd93aqv 69 1 The the DT cord-355477-7xd93aqv 69 2 helicase helicase NN cord-355477-7xd93aqv 69 3 is be VBZ cord-355477-7xd93aqv 69 4 then then RB cord-355477-7xd93aqv 69 5 released release VBN cord-355477-7xd93aqv 69 6 . . . cord-355477-7xd93aqv 70 1 ATPase ATPase NNP cord-355477-7xd93aqv 70 2 activity activity NN cord-355477-7xd93aqv 70 3 and and CC cord-355477-7xd93aqv 70 4 DNA dna NN cord-355477-7xd93aqv 70 5 duplex duplex NN cord-355477-7xd93aqv 70 6 - - HYPH cord-355477-7xd93aqv 70 7 unwinding unwind VBG cord-355477-7xd93aqv 70 8 activity activity NN cord-355477-7xd93aqv 70 9 were be VBD cord-355477-7xd93aqv 70 10 demonstrated demonstrate VBN cord-355477-7xd93aqv 70 11 by by IN cord-355477-7xd93aqv 70 12 purified purify VBN cord-355477-7xd93aqv 70 13 helicase helicase NN cord-355477-7xd93aqv 70 14 , , , cord-355477-7xd93aqv 70 15 indicating indicate VBG cord-355477-7xd93aqv 70 16 that that IN cord-355477-7xd93aqv 70 17 the the DT cord-355477-7xd93aqv 70 18 protein protein NN cord-355477-7xd93aqv 70 19 has have VBZ cord-355477-7xd93aqv 70 20 RNA rna NN cord-355477-7xd93aqv 70 21 polymerase polymerase NN cord-355477-7xd93aqv 70 22 activity activity NN cord-355477-7xd93aqv 70 23 . . . cord-355477-7xd93aqv 71 1 9 9 CD cord-355477-7xd93aqv 72 1 Together together RB cord-355477-7xd93aqv 72 2 with with IN cord-355477-7xd93aqv 72 3 the the DT cord-355477-7xd93aqv 72 4 M M NNP cord-355477-7xd93aqv 72 5 protein protein NN cord-355477-7xd93aqv 72 6 , , , cord-355477-7xd93aqv 72 7 the the DT cord-355477-7xd93aqv 72 8 spike spike NN cord-355477-7xd93aqv 72 9 ( ( -LRB- cord-355477-7xd93aqv 72 10 S s NN cord-355477-7xd93aqv 72 11 ) ) -RRB- cord-355477-7xd93aqv 72 12 protein protein NN cord-355477-7xd93aqv 72 13 is be VBZ cord-355477-7xd93aqv 72 14 believed believe VBN cord-355477-7xd93aqv 72 15 to to TO cord-355477-7xd93aqv 72 16 be be VB cord-355477-7xd93aqv 72 17 incorporated incorporate VBN cord-355477-7xd93aqv 72 18 into into IN cord-355477-7xd93aqv 72 19 the the DT cord-355477-7xd93aqv 72 20 viral viral JJ cord-355477-7xd93aqv 72 21 envelope envelope NN cord-355477-7xd93aqv 72 22 before before IN cord-355477-7xd93aqv 72 23 the the DT cord-355477-7xd93aqv 72 24 mature mature JJ cord-355477-7xd93aqv 72 25 virion virion NN cord-355477-7xd93aqv 72 26 is be VBZ cord-355477-7xd93aqv 72 27 released release VBN cord-355477-7xd93aqv 72 28 . . . cord-355477-7xd93aqv 73 1 Initial initial JJ cord-355477-7xd93aqv 73 2 analysis analysis NN cord-355477-7xd93aqv 73 3 of of IN cord-355477-7xd93aqv 73 4 the the DT cord-355477-7xd93aqv 73 5 1255a.a 1255a.a CD cord-355477-7xd93aqv 73 6 . . . cord-355477-7xd93aqv 74 1 peplomer peplomer NNP cord-355477-7xd93aqv 74 2 protein protein NN cord-355477-7xd93aqv 74 3 of of IN cord-355477-7xd93aqv 74 4 the the DT cord-355477-7xd93aqv 74 5 virus virus NN cord-355477-7xd93aqv 74 6 reveals reveal VBZ cord-355477-7xd93aqv 74 7 the the DT cord-355477-7xd93aqv 74 8 possible possible JJ cord-355477-7xd93aqv 74 9 existence existence NN cord-355477-7xd93aqv 74 10 of of IN cord-355477-7xd93aqv 74 11 a a DT cord-355477-7xd93aqv 74 12 signal signal JJ cord-355477-7xd93aqv 74 13 peptide peptide NN cord-355477-7xd93aqv 74 14 that that WDT cord-355477-7xd93aqv 74 15 would would MD cord-355477-7xd93aqv 74 16 most most RBS cord-355477-7xd93aqv 74 17 likely likely RB cord-355477-7xd93aqv 74 18 be be VB cord-355477-7xd93aqv 74 19 cleaved cleave VBN cord-355477-7xd93aqv 74 20 between between IN cord-355477-7xd93aqv 74 21 residues residue NNS cord-355477-7xd93aqv 74 22 13 13 CD cord-355477-7xd93aqv 74 23 and and CC cord-355477-7xd93aqv 74 24 14 14 CD cord-355477-7xd93aqv 74 25 . . . cord-355477-7xd93aqv 75 1 11 11 CD cord-355477-7xd93aqv 75 2 , , , cord-355477-7xd93aqv 75 3 12 12 CD cord-355477-7xd93aqv 75 4 It -PRON- PRP cord-355477-7xd93aqv 75 5 forms form VBZ cord-355477-7xd93aqv 75 6 typical typical JJ cord-355477-7xd93aqv 75 7 petal petal NN cord-355477-7xd93aqv 75 8 - - HYPH cord-355477-7xd93aqv 75 9 shaped shape VBN cord-355477-7xd93aqv 75 10 spikes spike NNS cord-355477-7xd93aqv 75 11 on on IN cord-355477-7xd93aqv 75 12 the the DT cord-355477-7xd93aqv 75 13 surface surface NN cord-355477-7xd93aqv 75 14 of of IN cord-355477-7xd93aqv 75 15 the the DT cord-355477-7xd93aqv 75 16 virion virion NN cord-355477-7xd93aqv 75 17 and and CC cord-355477-7xd93aqv 75 18 consists consist VBZ cord-355477-7xd93aqv 75 19 of of IN cord-355477-7xd93aqv 75 20 three three CD cord-355477-7xd93aqv 75 21 domains domain NNS cord-355477-7xd93aqv 75 22 , , , cord-355477-7xd93aqv 75 23 the the DT cord-355477-7xd93aqv 75 24 external external JJ cord-355477-7xd93aqv 75 25 N n CD cord-355477-7xd93aqv 75 26 - - HYPH cord-355477-7xd93aqv 75 27 terminal terminal NN cord-355477-7xd93aqv 75 28 domain domain NN cord-355477-7xd93aqv 75 29 with with IN cord-355477-7xd93aqv 75 30 its -PRON- PRP$ cord-355477-7xd93aqv 75 31 conserved conserved JJ cord-355477-7xd93aqv 75 32 S1 s1 NN cord-355477-7xd93aqv 75 33 and and CC cord-355477-7xd93aqv 75 34 S2 S2 NNP cord-355477-7xd93aqv 75 35 subdomains subdomain NNS cord-355477-7xd93aqv 75 36 , , , cord-355477-7xd93aqv 75 37 a a DT cord-355477-7xd93aqv 75 38 transmembrane transmembrane NN cord-355477-7xd93aqv 75 39 domain domain NN cord-355477-7xd93aqv 75 40 , , , cord-355477-7xd93aqv 75 41 and and CC cord-355477-7xd93aqv 75 42 a a DT cord-355477-7xd93aqv 75 43 short short JJ cord-355477-7xd93aqv 75 44 cytoplasmic cytoplasmic JJ cord-355477-7xd93aqv 75 45 domain domain NN cord-355477-7xd93aqv 75 46 at at IN cord-355477-7xd93aqv 75 47 the the DT cord-355477-7xd93aqv 75 48 C C NNP cord-355477-7xd93aqv 75 49 terminus terminus NN cord-355477-7xd93aqv 75 50 . . . cord-355477-7xd93aqv 76 1 S1 s1 NN cord-355477-7xd93aqv 76 2 is be VBZ cord-355477-7xd93aqv 76 3 the the DT cord-355477-7xd93aqv 76 4 receptor receptor NN cord-355477-7xd93aqv 76 5 - - HYPH cord-355477-7xd93aqv 76 6 binding bind VBG cord-355477-7xd93aqv 76 7 unit unit NN cord-355477-7xd93aqv 76 8 in in IN cord-355477-7xd93aqv 76 9 the the DT cord-355477-7xd93aqv 76 10 N n CD cord-355477-7xd93aqv 76 11 terminus terminus NN cord-355477-7xd93aqv 76 12 . . . cord-355477-7xd93aqv 77 1 Molecular molecular JJ cord-355477-7xd93aqv 77 2 modeling modeling NN cord-355477-7xd93aqv 77 3 of of IN cord-355477-7xd93aqv 77 4 the the DT cord-355477-7xd93aqv 77 5 S1 S1 NNP cord-355477-7xd93aqv 77 6 and and CC cord-355477-7xd93aqv 77 7 S2 S2 NNP cord-355477-7xd93aqv 77 8 subunits subunit NNS cord-355477-7xd93aqv 77 9 of of IN cord-355477-7xd93aqv 77 10 the the DT cord-355477-7xd93aqv 77 11 S S NNP cord-355477-7xd93aqv 77 12 glycoprotein glycoprotein NN cord-355477-7xd93aqv 77 13 suggest suggest VBP cord-355477-7xd93aqv 77 14 that that IN cord-355477-7xd93aqv 77 15 the the DT cord-355477-7xd93aqv 77 16 former former JJ cord-355477-7xd93aqv 77 17 unit unit NN cord-355477-7xd93aqv 77 18 consists consist VBZ cord-355477-7xd93aqv 77 19 mainly mainly RB cord-355477-7xd93aqv 77 20 of of IN cord-355477-7xd93aqv 77 21 antiparallel antiparallel RB cord-355477-7xd93aqv 77 22 ␤ ␤ NNP cord-355477-7xd93aqv 77 23 -sheets -sheet NNS cord-355477-7xd93aqv 77 24 with with IN cord-355477-7xd93aqv 77 25 dispersed dispersed JJ cord-355477-7xd93aqv 77 26 ␣ ␣ NN cord-355477-7xd93aqv 77 27 and and CC cord-355477-7xd93aqv 77 28 ␤ ␤ NNP cord-355477-7xd93aqv 77 29 regions region NNS cord-355477-7xd93aqv 77 30 , , , cord-355477-7xd93aqv 77 31 in in IN cord-355477-7xd93aqv 77 32 addition addition NN cord-355477-7xd93aqv 77 33 to to IN cord-355477-7xd93aqv 77 34 the the DT cord-355477-7xd93aqv 77 35 three three CD cord-355477-7xd93aqv 77 36 domains domain NNS cord-355477-7xd93aqv 77 37 identified identify VBN cord-355477-7xd93aqv 77 38 in in IN cord-355477-7xd93aqv 77 39 the the DT cord-355477-7xd93aqv 77 40 S2 S2 NNP cord-355477-7xd93aqv 77 41 unit unit NN cord-355477-7xd93aqv 77 42 . . . cord-355477-7xd93aqv 78 1 Entry entry NN cord-355477-7xd93aqv 78 2 of of IN cord-355477-7xd93aqv 78 3 CoVs CoVs NNP cord-355477-7xd93aqv 78 4 into into IN cord-355477-7xd93aqv 78 5 target target NN cord-355477-7xd93aqv 78 6 cells cell NNS cord-355477-7xd93aqv 78 7 is be VBZ cord-355477-7xd93aqv 78 8 initiated initiate VBN cord-355477-7xd93aqv 78 9 by by IN cord-355477-7xd93aqv 78 10 binding bind VBG cord-355477-7xd93aqv 78 11 of of IN cord-355477-7xd93aqv 78 12 the the DT cord-355477-7xd93aqv 78 13 viral viral JJ cord-355477-7xd93aqv 78 14 S S NNP cord-355477-7xd93aqv 78 15 protein protein NN cord-355477-7xd93aqv 78 16 to to IN cord-355477-7xd93aqv 78 17 receptor receptor NN cord-355477-7xd93aqv 78 18 molecules molecule NNS cord-355477-7xd93aqv 78 19 . . . cord-355477-7xd93aqv 79 1 The the DT cord-355477-7xd93aqv 79 2 S1 s1 NN cord-355477-7xd93aqv 79 3 domain domain NN cord-355477-7xd93aqv 79 4 of of IN cord-355477-7xd93aqv 79 5 SARS SARS NNP cord-355477-7xd93aqv 79 6 - - HYPH cord-355477-7xd93aqv 79 7 CoV CoV NNP cord-355477-7xd93aqv 79 8 is be VBZ cord-355477-7xd93aqv 79 9 significantly significantly RB cord-355477-7xd93aqv 79 10 different different JJ cord-355477-7xd93aqv 79 11 from from IN cord-355477-7xd93aqv 79 12 that that DT cord-355477-7xd93aqv 79 13 of of IN cord-355477-7xd93aqv 79 14 other other JJ cord-355477-7xd93aqv 79 15 human human JJ cord-355477-7xd93aqv 79 16 CoVs CoVs NNP cord-355477-7xd93aqv 79 17 , , , cord-355477-7xd93aqv 79 18 implying imply VBG cord-355477-7xd93aqv 79 19 that that IN cord-355477-7xd93aqv 79 20 these these DT cord-355477-7xd93aqv 79 21 viruses virus NNS cord-355477-7xd93aqv 79 22 are be VBP cord-355477-7xd93aqv 79 23 using use VBG cord-355477-7xd93aqv 79 24 different different JJ cord-355477-7xd93aqv 79 25 receptors receptor NNS cord-355477-7xd93aqv 79 26 for for IN cord-355477-7xd93aqv 79 27 host host NN cord-355477-7xd93aqv 79 28 cell cell NN cord-355477-7xd93aqv 79 29 entry entry NN cord-355477-7xd93aqv 79 30 . . . cord-355477-7xd93aqv 80 1 The the DT cord-355477-7xd93aqv 80 2 cellular cellular JJ cord-355477-7xd93aqv 80 3 receptor receptor NN cord-355477-7xd93aqv 80 4 of of IN cord-355477-7xd93aqv 80 5 several several JJ cord-355477-7xd93aqv 80 6 group group NN cord-355477-7xd93aqv 80 7 I -PRON- PRP cord-355477-7xd93aqv 80 8 CoVs CoVs NNP cord-355477-7xd93aqv 80 9 are be VBP cord-355477-7xd93aqv 80 10 aminopeptidase aminopeptidase NN cord-355477-7xd93aqv 80 11 N N NNP cord-355477-7xd93aqv 80 12 and and CC cord-355477-7xd93aqv 80 13 zinc zinc NN cord-355477-7xd93aqv 80 14 metalloprotease metalloprotease NNP cord-355477-7xd93aqv 80 15 , , , cord-355477-7xd93aqv 80 16 whereas whereas IN cord-355477-7xd93aqv 80 17 mouse mouse NNP cord-355477-7xd93aqv 80 18 hepatitis hepatitis NN cord-355477-7xd93aqv 80 19 virus virus NN cord-355477-7xd93aqv 80 20 ( ( -LRB- cord-355477-7xd93aqv 80 21 MHV mhv NN cord-355477-7xd93aqv 80 22 ) ) -RRB- cord-355477-7xd93aqv 80 23 ( ( -LRB- cord-355477-7xd93aqv 80 24 group group NN cord-355477-7xd93aqv 80 25 II II NNP cord-355477-7xd93aqv 80 26 ) ) -RRB- cord-355477-7xd93aqv 80 27 uses use VBZ cord-355477-7xd93aqv 80 28 carcinoembryonic carcinoembryonic NNP cord-355477-7xd93aqv 80 29 antigen antigen NN cord-355477-7xd93aqv 80 30 - - HYPH cord-355477-7xd93aqv 80 31 related relate VBN cord-355477-7xd93aqv 80 32 cell cell NN cord-355477-7xd93aqv 80 33 adhesion adhesion NN cord-355477-7xd93aqv 80 34 molecules molecule NNS cord-355477-7xd93aqv 80 35 as as IN cord-355477-7xd93aqv 80 36 a a DT cord-355477-7xd93aqv 80 37 cellular cellular JJ cord-355477-7xd93aqv 80 38 receptor receptor NN cord-355477-7xd93aqv 80 39 . . . cord-355477-7xd93aqv 81 1 In in IN cord-355477-7xd93aqv 81 2 the the DT cord-355477-7xd93aqv 81 3 case case NN cord-355477-7xd93aqv 81 4 of of IN cord-355477-7xd93aqv 81 5 SARS SARS NNP cord-355477-7xd93aqv 81 6 - - HYPH cord-355477-7xd93aqv 81 7 CoV CoV NNP cord-355477-7xd93aqv 81 8 , , , cord-355477-7xd93aqv 81 9 ACE2 ACE2 NNP cord-355477-7xd93aqv 81 10 was be VBD cord-355477-7xd93aqv 81 11 demonstrated demonstrate VBN cord-355477-7xd93aqv 81 12 to to TO cord-355477-7xd93aqv 81 13 be be VB cord-355477-7xd93aqv 81 14 a a DT cord-355477-7xd93aqv 81 15 functional functional JJ cord-355477-7xd93aqv 81 16 receptor receptor NN cord-355477-7xd93aqv 81 17 for for IN cord-355477-7xd93aqv 81 18 the the DT cord-355477-7xd93aqv 81 19 SARS SARS NNP cord-355477-7xd93aqv 81 20 - - HYPH cord-355477-7xd93aqv 81 21 CoV CoV NNP cord-355477-7xd93aqv 81 22 in in IN cord-355477-7xd93aqv 81 23 - - HYPH cord-355477-7xd93aqv 81 24 vitro vitro FW cord-355477-7xd93aqv 81 25 . . . cord-355477-7xd93aqv 82 1 Syncytia syncytia NN cord-355477-7xd93aqv 82 2 were be VBD cord-355477-7xd93aqv 82 3 observed observe VBN cord-355477-7xd93aqv 82 4 in in IN cord-355477-7xd93aqv 82 5 cell cell NN cord-355477-7xd93aqv 82 6 culture culture NN cord-355477-7xd93aqv 82 7 expressing express VBG cord-355477-7xd93aqv 82 8 ACE2 ACE2 NNP cord-355477-7xd93aqv 82 9 and and CC cord-355477-7xd93aqv 82 10 the the DT cord-355477-7xd93aqv 82 11 SARS SARS NNP cord-355477-7xd93aqv 82 12 - - HYPH cord-355477-7xd93aqv 82 13 CoV CoV NNP cord-355477-7xd93aqv 82 14 S1 S1 NNP cord-355477-7xd93aqv 82 15 domain domain NN cord-355477-7xd93aqv 82 16 , , , cord-355477-7xd93aqv 82 17 which which WDT cord-355477-7xd93aqv 82 18 could could MD cord-355477-7xd93aqv 82 19 be be VB cord-355477-7xd93aqv 82 20 inhibited inhibit VBN cord-355477-7xd93aqv 82 21 using use VBG cord-355477-7xd93aqv 82 22 anti anti JJ cord-355477-7xd93aqv 82 23 - - JJ cord-355477-7xd93aqv 82 24 ACE2 ace2 JJ cord-355477-7xd93aqv 82 25 antibody antibody NN cord-355477-7xd93aqv 82 26 . . . cord-355477-7xd93aqv 83 1 Fine fine JJ cord-355477-7xd93aqv 83 2 mapping mapping NN cord-355477-7xd93aqv 83 3 on on IN cord-355477-7xd93aqv 83 4 the the DT cord-355477-7xd93aqv 83 5 N n CD cord-355477-7xd93aqv 83 6 - - HYPH cord-355477-7xd93aqv 83 7 terminal terminal JJ cord-355477-7xd93aqv 83 8 unit unit NN cord-355477-7xd93aqv 83 9 of of IN cord-355477-7xd93aqv 83 10 the the DT cord-355477-7xd93aqv 83 11 S S NNP cord-355477-7xd93aqv 83 12 protein protein NN cord-355477-7xd93aqv 83 13 indicates indicate VBZ cord-355477-7xd93aqv 83 14 that that IN cord-355477-7xd93aqv 83 15 the the DT cord-355477-7xd93aqv 83 16 minimal minimal JJ cord-355477-7xd93aqv 83 17 receptor receptor NN cord-355477-7xd93aqv 83 18 - - HYPH cord-355477-7xd93aqv 83 19 binding bind VBG cord-355477-7xd93aqv 83 20 domain domain NN cord-355477-7xd93aqv 83 21 is be VBZ cord-355477-7xd93aqv 83 22 located locate VBN cord-355477-7xd93aqv 83 23 between between IN cord-355477-7xd93aqv 83 24 the the DT cord-355477-7xd93aqv 83 25 residues residue NNS cord-355477-7xd93aqv 83 26 318 318 CD cord-355477-7xd93aqv 83 27 - - HYPH cord-355477-7xd93aqv 83 28 510 510 CD cord-355477-7xd93aqv 83 29 . . . cord-355477-7xd93aqv 84 1 10 10 CD cord-355477-7xd93aqv 84 2 Antibodies antibody NNS cord-355477-7xd93aqv 84 3 specific specific JJ cord-355477-7xd93aqv 84 4 for for IN cord-355477-7xd93aqv 84 5 this this DT cord-355477-7xd93aqv 84 6 S1 S1 NNP cord-355477-7xd93aqv 84 7 subunit subunit NN cord-355477-7xd93aqv 84 8 of of IN cord-355477-7xd93aqv 84 9 the the DT cord-355477-7xd93aqv 84 10 SARS SARS NNP cord-355477-7xd93aqv 84 11 - - HYPH cord-355477-7xd93aqv 84 12 CoV CoV NNP cord-355477-7xd93aqv 84 13 S S NNP cord-355477-7xd93aqv 84 14 protein protein NN cord-355477-7xd93aqv 84 15 were be VBD cord-355477-7xd93aqv 84 16 shown show VBN cord-355477-7xd93aqv 84 17 to to TO cord-355477-7xd93aqv 84 18 neutralize neutralize VB cord-355477-7xd93aqv 84 19 SARS SARS NNP cord-355477-7xd93aqv 84 20 - - HYPH cord-355477-7xd93aqv 84 21 CoV CoV NNP cord-355477-7xd93aqv 84 22 infection infection NN cord-355477-7xd93aqv 84 23 . . . cord-355477-7xd93aqv 85 1 The the DT cord-355477-7xd93aqv 85 2 C c NN cord-355477-7xd93aqv 85 3 - - HYPH cord-355477-7xd93aqv 85 4 type type NN cord-355477-7xd93aqv 85 5 lectin lectin NN cord-355477-7xd93aqv 85 6 CD209L cd209l NN cord-355477-7xd93aqv 85 7 ( ( -LRB- cord-355477-7xd93aqv 85 8 also also RB cord-355477-7xd93aqv 85 9 called call VBN cord-355477-7xd93aqv 85 10 L L NNP cord-355477-7xd93aqv 85 11 - - HYPH cord-355477-7xd93aqv 85 12 SIGN SIGN NNP cord-355477-7xd93aqv 85 13 ) ) -RRB- cord-355477-7xd93aqv 85 14 , , , cord-355477-7xd93aqv 85 15 a a DT cord-355477-7xd93aqv 85 16 human human JJ cord-355477-7xd93aqv 85 17 cellular cellular JJ cord-355477-7xd93aqv 85 18 glycoprotein glycoprotein NN cord-355477-7xd93aqv 85 19 has have VBZ cord-355477-7xd93aqv 85 20 been be VBN cord-355477-7xd93aqv 85 21 reported report VBN cord-355477-7xd93aqv 85 22 to to TO cord-355477-7xd93aqv 85 23 serve serve VB cord-355477-7xd93aqv 85 24 as as IN cord-355477-7xd93aqv 85 25 an an DT cord-355477-7xd93aqv 85 26 alternative alternative JJ cord-355477-7xd93aqv 85 27 receptor receptor NN cord-355477-7xd93aqv 85 28 for for IN cord-355477-7xd93aqv 85 29 SARS- SARS- NNP cord-355477-7xd93aqv 86 1 CoV. CoV. NNP cord-355477-7xd93aqv 87 1 The the DT cord-355477-7xd93aqv 87 2 S S NNP cord-355477-7xd93aqv 87 3 protein protein NN cord-355477-7xd93aqv 87 4 of of IN cord-355477-7xd93aqv 87 5 SARS SARS NNP cord-355477-7xd93aqv 87 6 - - HYPH cord-355477-7xd93aqv 87 7 CoV CoV NNP cord-355477-7xd93aqv 87 8 contains contain VBZ cord-355477-7xd93aqv 87 9 23 23 CD cord-355477-7xd93aqv 87 10 putative putative JJ cord-355477-7xd93aqv 87 11 N n CD cord-355477-7xd93aqv 87 12 - - HYPH cord-355477-7xd93aqv 87 13 glycosylation glycosylation NN cord-355477-7xd93aqv 87 14 sites site NNS cord-355477-7xd93aqv 87 15 , , , cord-355477-7xd93aqv 87 16 among among IN cord-355477-7xd93aqv 87 17 which which WDT cord-355477-7xd93aqv 87 18 12 12 CD cord-355477-7xd93aqv 87 19 have have VBP cord-355477-7xd93aqv 87 20 been be VBN cord-355477-7xd93aqv 87 21 described describe VBN cord-355477-7xd93aqv 87 22 to to TO cord-355477-7xd93aqv 87 23 be be VB cord-355477-7xd93aqv 87 24 effectively effectively RB cord-355477-7xd93aqv 87 25 glycosylated glycosylate VBN cord-355477-7xd93aqv 87 26 . . . cord-355477-7xd93aqv 88 1 11 11 CD cord-355477-7xd93aqv 88 2 , , , cord-355477-7xd93aqv 88 3 12 12 CD cord-355477-7xd93aqv 89 1 The the DT cord-355477-7xd93aqv 89 2 S S NNP cord-355477-7xd93aqv 89 3 protein protein NN cord-355477-7xd93aqv 89 4 , , , cord-355477-7xd93aqv 89 5 when when WRB cord-355477-7xd93aqv 89 6 expressed express VBN cord-355477-7xd93aqv 89 7 alone alone RB cord-355477-7xd93aqv 89 8 , , , cord-355477-7xd93aqv 89 9 acquires acquire VBZ cord-355477-7xd93aqv 89 10 EndoH EndoH NNP cord-355477-7xd93aqv 89 11 - - HYPH cord-355477-7xd93aqv 89 12 resistant resistant JJ cord-355477-7xd93aqv 89 13 complex complex JJ cord-355477-7xd93aqv 89 14 N n CD cord-355477-7xd93aqv 89 15 - - HYPH cord-355477-7xd93aqv 89 16 glycans glycan NNS cord-355477-7xd93aqv 89 17 in in IN cord-355477-7xd93aqv 89 18 the the DT cord-355477-7xd93aqv 89 19 Golgi Golgi NNP cord-355477-7xd93aqv 89 20 within within IN cord-355477-7xd93aqv 89 21 30 30 CD cord-355477-7xd93aqv 89 22 min min NN cord-355477-7xd93aqv 89 23 following follow VBG cord-355477-7xd93aqv 89 24 expression expression NN cord-355477-7xd93aqv 89 25 . . . cord-355477-7xd93aqv 90 1 Both both DT cord-355477-7xd93aqv 90 2 high high JJ cord-355477-7xd93aqv 90 3 - - HYPH cord-355477-7xd93aqv 90 4 mannose mannose NN cord-355477-7xd93aqv 90 5 and and CC cord-355477-7xd93aqv 90 6 complex complex JJ cord-355477-7xd93aqv 90 7 glycan glycan NN cord-355477-7xd93aqv 90 8 N n NN cord-355477-7xd93aqv 90 9 - - HYPH cord-355477-7xd93aqv 90 10 glycoforms glycoform NNS cord-355477-7xd93aqv 90 11 have have VBP cord-355477-7xd93aqv 90 12 been be VBN cord-355477-7xd93aqv 90 13 detected detect VBN cord-355477-7xd93aqv 90 14 on on IN cord-355477-7xd93aqv 90 15 S S NNP cord-355477-7xd93aqv 90 16 trimers trimer NNS cord-355477-7xd93aqv 90 17 within within IN cord-355477-7xd93aqv 90 18 ER ER NNP cord-355477-7xd93aqv 90 19 and and CC cord-355477-7xd93aqv 90 20 Golgi Golgi NNP cord-355477-7xd93aqv 90 21 , , , cord-355477-7xd93aqv 90 22 respectively respectively RB cord-355477-7xd93aqv 90 23 , , , cord-355477-7xd93aqv 90 24 suggesting suggest VBG cord-355477-7xd93aqv 90 25 that that IN cord-355477-7xd93aqv 90 26 trimers trimer NNS cord-355477-7xd93aqv 90 27 form form VB cord-355477-7xd93aqv 90 28 in in IN cord-355477-7xd93aqv 90 29 the the DT cord-355477-7xd93aqv 90 30 ER er NN cord-355477-7xd93aqv 90 31 and and CC cord-355477-7xd93aqv 90 32 pass pass VB cord-355477-7xd93aqv 90 33 the the DT cord-355477-7xd93aqv 90 34 quality quality NN cord-355477-7xd93aqv 90 35 control control NN cord-355477-7xd93aqv 90 36 to to TO cord-355477-7xd93aqv 90 37 move move VB cord-355477-7xd93aqv 90 38 toward toward IN cord-355477-7xd93aqv 90 39 the the DT cord-355477-7xd93aqv 90 40 Golgi Golgi NNP cord-355477-7xd93aqv 90 41 to to TO cord-355477-7xd93aqv 90 42 acquire acquire VB cord-355477-7xd93aqv 90 43 complex complex JJ cord-355477-7xd93aqv 90 44 N n CD cord-355477-7xd93aqv 90 45 - - HYPH cord-355477-7xd93aqv 90 46 glycans glycan NNS cord-355477-7xd93aqv 90 47 . . . cord-355477-7xd93aqv 91 1 It -PRON- PRP cord-355477-7xd93aqv 91 2 has have VBZ cord-355477-7xd93aqv 91 3 also also RB cord-355477-7xd93aqv 91 4 been be VBN cord-355477-7xd93aqv 91 5 shown show VBN cord-355477-7xd93aqv 91 6 that that IN cord-355477-7xd93aqv 91 7 the the DT cord-355477-7xd93aqv 91 8 S S NNP cord-355477-7xd93aqv 91 9 glycoprotein glycoprotein NN cord-355477-7xd93aqv 91 10 is be VBZ cord-355477-7xd93aqv 91 11 present present JJ cord-355477-7xd93aqv 91 12 all all RB cord-355477-7xd93aqv 91 13 along along IN cord-355477-7xd93aqv 91 14 the the DT cord-355477-7xd93aqv 91 15 secretory secretory JJ cord-355477-7xd93aqv 91 16 pathway pathway NN cord-355477-7xd93aqv 91 17 from from IN cord-355477-7xd93aqv 91 18 the the DT cord-355477-7xd93aqv 91 19 ER ER NNP cord-355477-7xd93aqv 91 20 to to IN cord-355477-7xd93aqv 91 21 the the DT cord-355477-7xd93aqv 91 22 plasma plasma NN cord-355477-7xd93aqv 91 23 membrane membrane NN cord-355477-7xd93aqv 91 24 . . . cord-355477-7xd93aqv 92 1 13 13 CD cord-355477-7xd93aqv 93 1 Recently recently RB cord-355477-7xd93aqv 93 2 , , , cord-355477-7xd93aqv 93 3 structure structure NN cord-355477-7xd93aqv 93 4 of of IN cord-355477-7xd93aqv 93 5 SARS SARS NNP cord-355477-7xd93aqv 93 6 spike spike NN cord-355477-7xd93aqv 93 7 protein protein NN cord-355477-7xd93aqv 93 8 's 's POS cord-355477-7xd93aqv 93 9 receptor receptor NN cord-355477-7xd93aqv 93 10 - - HYPH cord-355477-7xd93aqv 93 11 binding bind VBG cord-355477-7xd93aqv 93 12 domain domain NN cord-355477-7xd93aqv 93 13 in in IN cord-355477-7xd93aqv 93 14 complex complex NN cord-355477-7xd93aqv 93 15 with with IN cord-355477-7xd93aqv 93 16 its -PRON- PRP$ cord-355477-7xd93aqv 93 17 receptor receptor NN cord-355477-7xd93aqv 93 18 , , , cord-355477-7xd93aqv 93 19 ACE2 ACE2 NNP cord-355477-7xd93aqv 93 20 has have VBZ cord-355477-7xd93aqv 93 21 been be VBN cord-355477-7xd93aqv 93 22 determined determine VBN cord-355477-7xd93aqv 93 23 using use VBG cord-355477-7xd93aqv 93 24 X x NN cord-355477-7xd93aqv 93 25 - - NN cord-355477-7xd93aqv 93 26 ray ray NN cord-355477-7xd93aqv 93 27 crystallography crystallography NN cord-355477-7xd93aqv 93 28 . . . cord-355477-7xd93aqv 94 1 The the DT cord-355477-7xd93aqv 94 2 structure structure NN cord-355477-7xd93aqv 94 3 though though IN cord-355477-7xd93aqv 94 4 determined determine VBN cord-355477-7xd93aqv 94 5 at at IN cord-355477-7xd93aqv 94 6 2.9A 2.9a NN cord-355477-7xd93aqv 94 7 , , , cord-355477-7xd93aqv 94 8 shows show VBZ cord-355477-7xd93aqv 94 9 potential potential NN cord-355477-7xd93aqv 94 10 for for IN cord-355477-7xd93aqv 94 11 usage usage NN cord-355477-7xd93aqv 94 12 in in IN cord-355477-7xd93aqv 94 13 designing design VBG cord-355477-7xd93aqv 94 14 vaccines vaccine NNS cord-355477-7xd93aqv 94 15 against against IN cord-355477-7xd93aqv 94 16 the the DT cord-355477-7xd93aqv 94 17 virus virus NN cord-355477-7xd93aqv 94 18 . . . cord-355477-7xd93aqv 95 1 14 14 CD cord-355477-7xd93aqv 95 2 Nucleocapsid Nucleocapsid NNP cord-355477-7xd93aqv 95 3 or or CC cord-355477-7xd93aqv 95 4 the the DT cord-355477-7xd93aqv 95 5 N n CD cord-355477-7xd93aqv 95 6 protein protein NN cord-355477-7xd93aqv 95 7 of of IN cord-355477-7xd93aqv 95 8 SARS SARS NNP cord-355477-7xd93aqv 95 9 - - HYPH cord-355477-7xd93aqv 95 10 CoV CoV NNP cord-355477-7xd93aqv 95 11 is be VBZ cord-355477-7xd93aqv 95 12 a a DT cord-355477-7xd93aqv 95 13 46-kDa 46-kda CD cord-355477-7xd93aqv 95 14 phosphoprotein phosphoprotein NN cord-355477-7xd93aqv 95 15 , , , cord-355477-7xd93aqv 95 16 which which WDT cord-355477-7xd93aqv 95 17 shows show VBZ cord-355477-7xd93aqv 95 18 homology homology NN cord-355477-7xd93aqv 95 19 with with IN cord-355477-7xd93aqv 95 20 other other JJ cord-355477-7xd93aqv 95 21 members member NNS cord-355477-7xd93aqv 95 22 of of IN cord-355477-7xd93aqv 95 23 CoV CoV NNP cord-355477-7xd93aqv 95 24 family family NN cord-355477-7xd93aqv 95 25 . . . cord-355477-7xd93aqv 96 1 Similar similar JJ cord-355477-7xd93aqv 96 2 to to IN cord-355477-7xd93aqv 96 3 other other JJ cord-355477-7xd93aqv 96 4 CoVs CoVs NNP cord-355477-7xd93aqv 96 5 , , , cord-355477-7xd93aqv 96 6 it -PRON- PRP cord-355477-7xd93aqv 96 7 gets get VBZ cord-355477-7xd93aqv 96 8 abundantly abundantly RB cord-355477-7xd93aqv 96 9 expressed express VBN cord-355477-7xd93aqv 96 10 during during IN cord-355477-7xd93aqv 96 11 infection infection NN cord-355477-7xd93aqv 96 12 and and CC cord-355477-7xd93aqv 96 13 antibodies antibody NNS cord-355477-7xd93aqv 96 14 against against IN cord-355477-7xd93aqv 96 15 N n CD cord-355477-7xd93aqv 96 16 have have VBP cord-355477-7xd93aqv 96 17 been be VBN cord-355477-7xd93aqv 96 18 detected detect VBN cord-355477-7xd93aqv 96 19 in in IN cord-355477-7xd93aqv 96 20 SARS SARS NNP cord-355477-7xd93aqv 96 21 patients patient NNS cord-355477-7xd93aqv 96 22 . . . cord-355477-7xd93aqv 97 1 [ [ -LRB- cord-355477-7xd93aqv 97 2 15 15 CD cord-355477-7xd93aqv 97 3 ] ] -RRB- cord-355477-7xd93aqv 97 4 [ [ -LRB- cord-355477-7xd93aqv 97 5 16 16 CD cord-355477-7xd93aqv 97 6 ] ] -RRB- cord-355477-7xd93aqv 97 7 [ [ -LRB- cord-355477-7xd93aqv 97 8 17 17 CD cord-355477-7xd93aqv 97 9 ] ] -RRB- cord-355477-7xd93aqv 98 1 [ [ -LRB- cord-355477-7xd93aqv 98 2 18 18 CD cord-355477-7xd93aqv 98 3 ] ] -RRB- cord-355477-7xd93aqv 98 4 N n CD cord-355477-7xd93aqv 98 5 protein protein NN cord-355477-7xd93aqv 98 6 of of IN cord-355477-7xd93aqv 98 7 most most JJS cord-355477-7xd93aqv 98 8 CoVs CoVs NNP cord-355477-7xd93aqv 98 9 contains contain VBZ cord-355477-7xd93aqv 98 10 multiple multiple JJ cord-355477-7xd93aqv 98 11 epitopic epitopic JJ cord-355477-7xd93aqv 98 12 sites site NNS cord-355477-7xd93aqv 98 13 lying lie VBG cord-355477-7xd93aqv 98 14 most most RBS cord-355477-7xd93aqv 98 15 commonly commonly RB cord-355477-7xd93aqv 98 16 at at IN cord-355477-7xd93aqv 98 17 their -PRON- PRP$ cord-355477-7xd93aqv 98 18 C C NNP cord-355477-7xd93aqv 98 19 terminus terminus NN cord-355477-7xd93aqv 98 20 . . . cord-355477-7xd93aqv 99 1 The the DT cord-355477-7xd93aqv 99 2 epitope epitope NN cord-355477-7xd93aqv 99 3 site site NN cord-355477-7xd93aqv 99 4 for for IN cord-355477-7xd93aqv 99 5 TGEV TGEV NNP cord-355477-7xd93aqv 99 6 is be VBZ cord-355477-7xd93aqv 99 7 located locate VBN cord-355477-7xd93aqv 99 8 around around IN cord-355477-7xd93aqv 99 9 codons codon NNS cord-355477-7xd93aqv 99 10 360 360 CD cord-355477-7xd93aqv 99 11 - - HYPH cord-355477-7xd93aqv 99 12 382 382 CD cord-355477-7xd93aqv 99 13 , , , cord-355477-7xd93aqv 99 14 19 19 CD cord-355477-7xd93aqv 99 15 for for IN cord-355477-7xd93aqv 99 16 MHV MHV NNP cord-355477-7xd93aqv 100 1 it -PRON- PRP cord-355477-7xd93aqv 100 2 is be VBZ cord-355477-7xd93aqv 100 3 at at IN cord-355477-7xd93aqv 100 4 381 381 CD cord-355477-7xd93aqv 100 5 - - SYM cord-355477-7xd93aqv 100 6 405 405 CD cord-355477-7xd93aqv 100 7 20 20 CD cord-355477-7xd93aqv 100 8 and and CC cord-355477-7xd93aqv 100 9 for for IN cord-355477-7xd93aqv 100 10 infectious infectious JJ cord-355477-7xd93aqv 100 11 bronchitis bronchitis NN cord-355477-7xd93aqv 100 12 virus virus NN cord-355477-7xd93aqv 100 13 ( ( -LRB- cord-355477-7xd93aqv 100 14 IBV IBV NNP cord-355477-7xd93aqv 100 15 ) ) -RRB- cord-355477-7xd93aqv 101 1 it -PRON- PRP cord-355477-7xd93aqv 101 2 is be VBZ cord-355477-7xd93aqv 101 3 located locate VBN cord-355477-7xd93aqv 101 4 at at IN cord-355477-7xd93aqv 101 5 360 360 CD cord-355477-7xd93aqv 101 6 - - SYM cord-355477-7xd93aqv 101 7 409 409 CD cord-355477-7xd93aqv 101 8 , , , cord-355477-7xd93aqv 101 9 21 21 CD cord-355477-7xd93aqv 101 10 all all DT cord-355477-7xd93aqv 101 11 at at IN cord-355477-7xd93aqv 101 12 the the DT cord-355477-7xd93aqv 101 13 C C NNP cord-355477-7xd93aqv 101 14 terminus terminus NN cord-355477-7xd93aqv 101 15 . . . cord-355477-7xd93aqv 102 1 Likewise likewise RB cord-355477-7xd93aqv 102 2 SARS SARS NNP cord-355477-7xd93aqv 102 3 - - HYPH cord-355477-7xd93aqv 102 4 CoV CoV NNP cord-355477-7xd93aqv 102 5 , , , cord-355477-7xd93aqv 102 6 N N NNP cord-355477-7xd93aqv 102 7 protein protein NN cord-355477-7xd93aqv 102 8 has have VBZ cord-355477-7xd93aqv 102 9 been be VBN cord-355477-7xd93aqv 102 10 found find VBN cord-355477-7xd93aqv 102 11 to to TO cord-355477-7xd93aqv 102 12 contain contain VB cord-355477-7xd93aqv 102 13 its -PRON- PRP$ cord-355477-7xd93aqv 102 14 most most RBS cord-355477-7xd93aqv 102 15 antigenic antigenic JJ cord-355477-7xd93aqv 102 16 site site NN cord-355477-7xd93aqv 102 17 at at IN cord-355477-7xd93aqv 102 18 the the DT cord-355477-7xd93aqv 102 19 C C NNP cord-355477-7xd93aqv 102 20 terminus terminus NN cord-355477-7xd93aqv 102 21 from from IN cord-355477-7xd93aqv 102 22 codons codon NNS cord-355477-7xd93aqv 102 23 371 371 CD cord-355477-7xd93aqv 102 24 - - SYM cord-355477-7xd93aqv 102 25 407 407 CD cord-355477-7xd93aqv 102 26 . . . cord-355477-7xd93aqv 103 1 22 22 CD cord-355477-7xd93aqv 104 1 This this DT cord-355477-7xd93aqv 104 2 makes make VBZ cord-355477-7xd93aqv 104 3 N n CD cord-355477-7xd93aqv 104 4 an an DT cord-355477-7xd93aqv 104 5 excellent excellent JJ cord-355477-7xd93aqv 104 6 candidate candidate NN cord-355477-7xd93aqv 104 7 for for IN cord-355477-7xd93aqv 104 8 diagnostic diagnostic JJ cord-355477-7xd93aqv 104 9 purposes purpose NNS cord-355477-7xd93aqv 104 10 . . . cord-355477-7xd93aqv 105 1 Being be VBG cord-355477-7xd93aqv 105 2 a a DT cord-355477-7xd93aqv 105 3 multipurpose multipurpose JJ cord-355477-7xd93aqv 105 4 protein protein NN cord-355477-7xd93aqv 105 5 , , , cord-355477-7xd93aqv 105 6 it -PRON- PRP cord-355477-7xd93aqv 105 7 plays play VBZ cord-355477-7xd93aqv 105 8 a a DT cord-355477-7xd93aqv 105 9 vital vital JJ cord-355477-7xd93aqv 105 10 role role NN cord-355477-7xd93aqv 105 11 during during IN cord-355477-7xd93aqv 105 12 virion virion NN cord-355477-7xd93aqv 105 13 assembly assembly NN cord-355477-7xd93aqv 105 14 . . . cord-355477-7xd93aqv 106 1 The the DT cord-355477-7xd93aqv 106 2 process process NN cord-355477-7xd93aqv 106 3 of of IN cord-355477-7xd93aqv 106 4 virion virion NN cord-355477-7xd93aqv 106 5 assembly assembly NN cord-355477-7xd93aqv 106 6 requires require VBZ cord-355477-7xd93aqv 106 7 efficient efficient JJ cord-355477-7xd93aqv 106 8 packaging packaging NN cord-355477-7xd93aqv 106 9 of of IN cord-355477-7xd93aqv 106 10 the the DT cord-355477-7xd93aqv 106 11 viral viral JJ cord-355477-7xd93aqv 106 12 RNA RNA NNP cord-355477-7xd93aqv 106 13 into into IN cord-355477-7xd93aqv 106 14 the the DT cord-355477-7xd93aqv 106 15 virion virion NN cord-355477-7xd93aqv 106 16 . . . cord-355477-7xd93aqv 107 1 For for IN cord-355477-7xd93aqv 107 2 this this DT cord-355477-7xd93aqv 107 3 , , , cord-355477-7xd93aqv 107 4 N N NNP cord-355477-7xd93aqv 107 5 protein protein NN cord-355477-7xd93aqv 107 6 associates associate NNS cord-355477-7xd93aqv 107 7 with with IN cord-355477-7xd93aqv 107 8 the the DT cord-355477-7xd93aqv 107 9 viral viral JJ cord-355477-7xd93aqv 107 10 genomic genomic JJ cord-355477-7xd93aqv 107 11 RNA RNA NNP cord-355477-7xd93aqv 107 12 , , , cord-355477-7xd93aqv 107 13 and and CC cord-355477-7xd93aqv 107 14 together together RB cord-355477-7xd93aqv 107 15 they -PRON- PRP cord-355477-7xd93aqv 107 16 form form VBP cord-355477-7xd93aqv 107 17 the the DT cord-355477-7xd93aqv 107 18 ribonucleoprotein ribonucleoprotein NN cord-355477-7xd93aqv 107 19 . . . cord-355477-7xd93aqv 108 1 In in IN cord-355477-7xd93aqv 108 2 MHV MHV NNP cord-355477-7xd93aqv 108 3 it -PRON- PRP cord-355477-7xd93aqv 108 4 has have VBZ cord-355477-7xd93aqv 108 5 been be VBN cord-355477-7xd93aqv 108 6 shown show VBN cord-355477-7xd93aqv 108 7 that that IN cord-355477-7xd93aqv 108 8 N n CD cord-355477-7xd93aqv 108 9 protein protein NN cord-355477-7xd93aqv 108 10 does do VBZ cord-355477-7xd93aqv 108 11 possess possess VB cord-355477-7xd93aqv 108 12 RNA RNA NNP cord-355477-7xd93aqv 108 13 - - HYPH cord-355477-7xd93aqv 108 14 binding bind VBG cord-355477-7xd93aqv 108 15 activity activity NN cord-355477-7xd93aqv 108 16 . . . cord-355477-7xd93aqv 109 1 16 16 CD cord-355477-7xd93aqv 110 1 The the DT cord-355477-7xd93aqv 110 2 structure structure NN cord-355477-7xd93aqv 110 3 of of IN cord-355477-7xd93aqv 110 4 the the DT cord-355477-7xd93aqv 110 5 N n CD cord-355477-7xd93aqv 110 6 terminal terminal NN cord-355477-7xd93aqv 110 7 ( ( -LRB- cord-355477-7xd93aqv 110 8 49 49 CD cord-355477-7xd93aqv 110 9 - - SYM cord-355477-7xd93aqv 110 10 178 178 CD cord-355477-7xd93aqv 110 11 aa aa NNP cord-355477-7xd93aqv 110 12 ) ) -RRB- cord-355477-7xd93aqv 110 13 region region NN cord-355477-7xd93aqv 110 14 of of IN cord-355477-7xd93aqv 110 15 the the DT cord-355477-7xd93aqv 110 16 N N NNP cord-355477-7xd93aqv 110 17 protein protein NN cord-355477-7xd93aqv 110 18 has have VBZ cord-355477-7xd93aqv 110 19 been be VBN cord-355477-7xd93aqv 110 20 solved solve VBN cord-355477-7xd93aqv 110 21 by by IN cord-355477-7xd93aqv 110 22 a a DT cord-355477-7xd93aqv 110 23 group group NN cord-355477-7xd93aqv 110 24 at at IN cord-355477-7xd93aqv 110 25 the the DT cord-355477-7xd93aqv 110 26 Abbott Abbott NNP cord-355477-7xd93aqv 110 27 Laboratories Laboratories NNP cord-355477-7xd93aqv 110 28 , , , cord-355477-7xd93aqv 110 29 Illinois Illinois NNP cord-355477-7xd93aqv 110 30 , , , cord-355477-7xd93aqv 110 31 USA USA NNP cord-355477-7xd93aqv 110 32 . . . cord-355477-7xd93aqv 111 1 The the DT cord-355477-7xd93aqv 111 2 structure structure NN cord-355477-7xd93aqv 111 3 reveals reveal VBZ cord-355477-7xd93aqv 111 4 an an DT cord-355477-7xd93aqv 111 5 RNA rna NN cord-355477-7xd93aqv 111 6 - - HYPH cord-355477-7xd93aqv 111 7 binding bind VBG cord-355477-7xd93aqv 111 8 domain domain NN cord-355477-7xd93aqv 111 9 similar similar JJ cord-355477-7xd93aqv 111 10 to to IN cord-355477-7xd93aqv 111 11 U1A U1A NNP cord-355477-7xd93aqv 111 12 RNA RNA NNP cord-355477-7xd93aqv 111 13 - - HYPH cord-355477-7xd93aqv 111 14 binding bind VBG cord-355477-7xd93aqv 111 15 protein protein NN cord-355477-7xd93aqv 111 16 . . . cord-355477-7xd93aqv 112 1 23 23 CD cord-355477-7xd93aqv 112 2 Studies study NNS cord-355477-7xd93aqv 112 3 have have VBP cord-355477-7xd93aqv 112 4 also also RB cord-355477-7xd93aqv 112 5 revealed reveal VBN cord-355477-7xd93aqv 112 6 that that IN cord-355477-7xd93aqv 112 7 packaging packaging NN cord-355477-7xd93aqv 112 8 of of IN cord-355477-7xd93aqv 112 9 SARS SARS NNP cord-355477-7xd93aqv 112 10 RNA RNA NNP cord-355477-7xd93aqv 112 11 into into IN cord-355477-7xd93aqv 112 12 virus virus NN cord-355477-7xd93aqv 112 13 - - HYPH cord-355477-7xd93aqv 112 14 like like JJ cord-355477-7xd93aqv 112 15 particles particle NNS cord-355477-7xd93aqv 112 16 ( ( -LRB- cord-355477-7xd93aqv 112 17 VLPs vlp NNS cord-355477-7xd93aqv 112 18 ) ) -RRB- cord-355477-7xd93aqv 112 19 is be VBZ cord-355477-7xd93aqv 112 20 dependent dependent JJ cord-355477-7xd93aqv 112 21 on on IN cord-355477-7xd93aqv 112 22 N n CD cord-355477-7xd93aqv 112 23 protein protein NN cord-355477-7xd93aqv 112 24 . . . cord-355477-7xd93aqv 113 1 Packaging packaging NN cord-355477-7xd93aqv 113 2 signal signal NN cord-355477-7xd93aqv 113 3 within within IN cord-355477-7xd93aqv 113 4 a a DT cord-355477-7xd93aqv 113 5 domain domain NN cord-355477-7xd93aqv 113 6 from from IN cord-355477-7xd93aqv 113 7 nucleotide nucleotide JJ cord-355477-7xd93aqv 113 8 19715 19715 CD cord-355477-7xd93aqv 113 9 - - SYM cord-355477-7xd93aqv 113 10 20294 20294 CD cord-355477-7xd93aqv 113 11 of of IN cord-355477-7xd93aqv 113 12 genomic genomic JJ cord-355477-7xd93aqv 113 13 RNA RNA NNP cord-355477-7xd93aqv 113 14 and and CC cord-355477-7xd93aqv 113 15 the the DT cord-355477-7xd93aqv 113 16 N N NNP cord-355477-7xd93aqv 113 17 terminal terminal NN cord-355477-7xd93aqv 113 18 structure structure NN cord-355477-7xd93aqv 113 19 of of IN cord-355477-7xd93aqv 113 20 N n CD cord-355477-7xd93aqv 113 21 protein protein NN cord-355477-7xd93aqv 113 22 are be VBP cord-355477-7xd93aqv 113 23 essential essential JJ cord-355477-7xd93aqv 113 24 for for IN cord-355477-7xd93aqv 113 25 packaging packaging NN cord-355477-7xd93aqv 113 26 and and CC cord-355477-7xd93aqv 113 27 RNA rna NN cord-355477-7xd93aqv 113 28 - - HYPH cord-355477-7xd93aqv 113 29 binding bind VBG cord-355477-7xd93aqv 113 30 activity activity NN cord-355477-7xd93aqv 113 31 , , , cord-355477-7xd93aqv 113 32 respectively respectively RB cord-355477-7xd93aqv 113 33 . . . cord-355477-7xd93aqv 114 1 24 24 CD cord-355477-7xd93aqv 114 2 Purified purify VBN cord-355477-7xd93aqv 114 3 SARS SARS NNP cord-355477-7xd93aqv 114 4 - - HYPH cord-355477-7xd93aqv 114 5 CoV CoV NNP cord-355477-7xd93aqv 114 6 has have VBZ cord-355477-7xd93aqv 114 7 been be VBN cord-355477-7xd93aqv 114 8 shown show VBN cord-355477-7xd93aqv 114 9 to to TO cord-355477-7xd93aqv 114 10 have have VB cord-355477-7xd93aqv 114 11 RNA RNA NNP cord-355477-7xd93aqv 114 12 chaperone chaperone NN cord-355477-7xd93aqv 114 13 activity activity NN cord-355477-7xd93aqv 114 14 . . . cord-355477-7xd93aqv 115 1 51 51 CD cord-355477-7xd93aqv 115 2 Self Self NNP cord-355477-7xd93aqv 115 3 - - HYPH cord-355477-7xd93aqv 115 4 association association NNP cord-355477-7xd93aqv 115 5 of of IN cord-355477-7xd93aqv 115 6 N N NNP cord-355477-7xd93aqv 115 7 protein protein NN cord-355477-7xd93aqv 115 8 governs govern VBZ cord-355477-7xd93aqv 115 9 the the DT cord-355477-7xd93aqv 115 10 formation formation NN cord-355477-7xd93aqv 115 11 of of IN cord-355477-7xd93aqv 115 12 viral viral JJ cord-355477-7xd93aqv 115 13 capsid capsid NN cord-355477-7xd93aqv 115 14 to to IN cord-355477-7xd93aqv 115 15 a a DT cord-355477-7xd93aqv 115 16 large large JJ cord-355477-7xd93aqv 115 17 extent extent NN cord-355477-7xd93aqv 115 18 and and CC cord-355477-7xd93aqv 115 19 has have VBZ cord-355477-7xd93aqv 115 20 been be VBN cord-355477-7xd93aqv 115 21 observed observe VBN cord-355477-7xd93aqv 115 22 in in IN cord-355477-7xd93aqv 115 23 many many JJ cord-355477-7xd93aqv 115 24 viruses virus NNS cord-355477-7xd93aqv 115 25 . . . cord-355477-7xd93aqv 116 1 For for IN cord-355477-7xd93aqv 116 2 SARS SARS NNP cord-355477-7xd93aqv 116 3 - - HYPH cord-355477-7xd93aqv 116 4 CoV CoV NNP cord-355477-7xd93aqv 116 5 , , , cord-355477-7xd93aqv 116 6 two two CD cord-355477-7xd93aqv 116 7 groups group NNS cord-355477-7xd93aqv 116 8 have have VBP cord-355477-7xd93aqv 116 9 shown show VBN cord-355477-7xd93aqv 116 10 that that IN cord-355477-7xd93aqv 116 11 N n CD cord-355477-7xd93aqv 116 12 protein protein NN cord-355477-7xd93aqv 116 13 does do VBZ cord-355477-7xd93aqv 116 14 dimerize dimerize NN cord-355477-7xd93aqv 116 15 . . . cord-355477-7xd93aqv 117 1 The the DT cord-355477-7xd93aqv 117 2 interaction interaction NN cord-355477-7xd93aqv 117 3 domain domain NN cord-355477-7xd93aqv 117 4 responsible responsible JJ cord-355477-7xd93aqv 117 5 for for IN cord-355477-7xd93aqv 117 6 dimerization dimerization NN cord-355477-7xd93aqv 117 7 was be VBD cord-355477-7xd93aqv 117 8 first first RB cord-355477-7xd93aqv 117 9 shown show VBN cord-355477-7xd93aqv 117 10 to to TO cord-355477-7xd93aqv 117 11 be be VB cord-355477-7xd93aqv 117 12 residing reside VBG cord-355477-7xd93aqv 117 13 in in IN cord-355477-7xd93aqv 117 14 the the DT cord-355477-7xd93aqv 117 15 C C NNP cord-355477-7xd93aqv 117 16 terminal terminal NN cord-355477-7xd93aqv 117 17 209 209 CD cord-355477-7xd93aqv 117 18 amino amino NN cord-355477-7xd93aqv 117 19 acid acid NN cord-355477-7xd93aqv 117 20 residues residue NNS cord-355477-7xd93aqv 117 21 25 25 CD cord-355477-7xd93aqv 117 22 and and CC cord-355477-7xd93aqv 117 23 was be VBD cord-355477-7xd93aqv 117 24 further further RB cord-355477-7xd93aqv 117 25 narrowed narrow VBN cord-355477-7xd93aqv 117 26 down down RP cord-355477-7xd93aqv 117 27 to to IN cord-355477-7xd93aqv 117 28 138 138 CD cord-355477-7xd93aqv 117 29 amino amino NN cord-355477-7xd93aqv 117 30 acid acid NN cord-355477-7xd93aqv 117 31 residues residue NNS cord-355477-7xd93aqv 117 32 ( ( -LRB- cord-355477-7xd93aqv 117 33 between between IN cord-355477-7xd93aqv 117 34 285 285 CD cord-355477-7xd93aqv 117 35 and and CC cord-355477-7xd93aqv 117 36 422 422 CD cord-355477-7xd93aqv 117 37 ) ) -RRB- cord-355477-7xd93aqv 117 38 at at IN cord-355477-7xd93aqv 117 39 the the DT cord-355477-7xd93aqv 117 40 C C NNP cord-355477-7xd93aqv 117 41 terminus terminus NN cord-355477-7xd93aqv 117 42 of of IN cord-355477-7xd93aqv 117 43 the the DT cord-355477-7xd93aqv 117 44 protein protein NN cord-355477-7xd93aqv 117 45 . . . cord-355477-7xd93aqv 118 1 26 26 CD cord-355477-7xd93aqv 118 2 N n NN cord-355477-7xd93aqv 118 3 's 's POS cord-355477-7xd93aqv 118 4 ability ability NN cord-355477-7xd93aqv 118 5 to to TO cord-355477-7xd93aqv 118 6 form form VB cord-355477-7xd93aqv 118 7 oligomers oligomer NNS cord-355477-7xd93aqv 118 8 ( ( -LRB- cord-355477-7xd93aqv 118 9 trimers trimer NNS cord-355477-7xd93aqv 118 10 , , , cord-355477-7xd93aqv 118 11 tetramers tetramer NNS cord-355477-7xd93aqv 118 12 , , , cord-355477-7xd93aqv 118 13 and and CC cord-355477-7xd93aqv 118 14 hexamers hexamers NNP cord-355477-7xd93aqv 118 15 ) ) -RRB- cord-355477-7xd93aqv 118 16 has have VBZ cord-355477-7xd93aqv 118 17 been be VBN cord-355477-7xd93aqv 118 18 demonstrated demonstrate VBN cord-355477-7xd93aqv 118 19 to to TO cord-355477-7xd93aqv 118 20 be be VB cord-355477-7xd93aqv 118 21 residing reside VBG cord-355477-7xd93aqv 118 22 in in IN cord-355477-7xd93aqv 118 23 residues residue NNS cord-355477-7xd93aqv 118 24 343 343 CD cord-355477-7xd93aqv 118 25 - - SYM cord-355477-7xd93aqv 118 26 402 402 CD cord-355477-7xd93aqv 118 27 . . . cord-355477-7xd93aqv 119 1 49 49 CD cord-355477-7xd93aqv 119 2 N n NN cord-355477-7xd93aqv 119 3 also also RB cord-355477-7xd93aqv 119 4 interacts interact VBZ cord-355477-7xd93aqv 119 5 with with IN cord-355477-7xd93aqv 119 6 the the DT cord-355477-7xd93aqv 119 7 membrane membrane NN cord-355477-7xd93aqv 119 8 protein protein NN cord-355477-7xd93aqv 119 9 . . . cord-355477-7xd93aqv 120 1 Amino amino NN cord-355477-7xd93aqv 120 2 acids acid NNS cord-355477-7xd93aqv 120 3 211 211 CD cord-355477-7xd93aqv 120 4 - - SYM cord-355477-7xd93aqv 120 5 254 254 CD cord-355477-7xd93aqv 120 6 , , , cord-355477-7xd93aqv 120 7 especially especially RB cord-355477-7xd93aqv 120 8 tetrad tetrad NNP cord-355477-7xd93aqv 120 9 glutamines glutamines NNP cord-355477-7xd93aqv 120 10 ( ( -LRB- cord-355477-7xd93aqv 120 11 240 240 CD cord-355477-7xd93aqv 120 12 QQQQ QQQQ NNP cord-355477-7xd93aqv 120 13 243 243 CD cord-355477-7xd93aqv 120 14 ) ) -RRB- cord-355477-7xd93aqv 120 15 , , , cord-355477-7xd93aqv 120 16 are be VBP cord-355477-7xd93aqv 120 17 essential essential JJ cord-355477-7xd93aqv 120 18 for for IN cord-355477-7xd93aqv 120 19 this this DT cord-355477-7xd93aqv 120 20 interaction interaction NN cord-355477-7xd93aqv 120 21 . . . cord-355477-7xd93aqv 121 1 50 50 CD cord-355477-7xd93aqv 122 1 Apart apart RB cord-355477-7xd93aqv 122 2 from from IN cord-355477-7xd93aqv 122 3 interactions interaction NNS cord-355477-7xd93aqv 122 4 among among IN cord-355477-7xd93aqv 122 5 viral viral JJ cord-355477-7xd93aqv 122 6 proteins protein NNS cord-355477-7xd93aqv 122 7 , , , cord-355477-7xd93aqv 122 8 interactions interaction NNS cord-355477-7xd93aqv 122 9 with with IN cord-355477-7xd93aqv 122 10 the the DT cord-355477-7xd93aqv 122 11 proteins protein NNS cord-355477-7xd93aqv 122 12 of of IN cord-355477-7xd93aqv 122 13 the the DT cord-355477-7xd93aqv 122 14 host host NN cord-355477-7xd93aqv 122 15 play play VBP cord-355477-7xd93aqv 122 16 a a DT cord-355477-7xd93aqv 122 17 major major JJ cord-355477-7xd93aqv 122 18 role role NN cord-355477-7xd93aqv 122 19 in in IN cord-355477-7xd93aqv 122 20 the the DT cord-355477-7xd93aqv 122 21 establishment establishment NN cord-355477-7xd93aqv 122 22 of of IN cord-355477-7xd93aqv 122 23 viral viral JJ cord-355477-7xd93aqv 122 24 infection infection NN cord-355477-7xd93aqv 122 25 . . . cord-355477-7xd93aqv 123 1 Hence hence RB cord-355477-7xd93aqv 123 2 mapping map VBG cord-355477-7xd93aqv 123 3 these these DT cord-355477-7xd93aqv 123 4 viral viral JJ cord-355477-7xd93aqv 123 5 host host NN cord-355477-7xd93aqv 123 6 protein protein NN cord-355477-7xd93aqv 123 7 interactions interaction NNS cord-355477-7xd93aqv 123 8 provides provide VBZ cord-355477-7xd93aqv 123 9 vital vital JJ cord-355477-7xd93aqv 123 10 hints hint NNS cord-355477-7xd93aqv 123 11 about about IN cord-355477-7xd93aqv 123 12 how how WRB cord-355477-7xd93aqv 123 13 infection infection NN cord-355477-7xd93aqv 123 14 actually actually RB cord-355477-7xd93aqv 123 15 takes take VBZ cord-355477-7xd93aqv 123 16 place place NN cord-355477-7xd93aqv 123 17 and and CC cord-355477-7xd93aqv 123 18 progresses progress VBZ cord-355477-7xd93aqv 123 19 . . . cord-355477-7xd93aqv 124 1 It -PRON- PRP cord-355477-7xd93aqv 124 2 has have VBZ cord-355477-7xd93aqv 124 3 been be VBN cord-355477-7xd93aqv 124 4 shown show VBN cord-355477-7xd93aqv 124 5 that that IN cord-355477-7xd93aqv 124 6 N n NN cord-355477-7xd93aqv 124 7 binds bind VBZ cord-355477-7xd93aqv 124 8 tightly tightly RB cord-355477-7xd93aqv 124 9 to to IN cord-355477-7xd93aqv 124 10 human human JJ cord-355477-7xd93aqv 124 11 cyclophilin cyclophilin NNP cord-355477-7xd93aqv 124 12 A A NNP cord-355477-7xd93aqv 124 13 ( ( -LRB- cord-355477-7xd93aqv 124 14 cypA cypA NNP cord-355477-7xd93aqv 124 15 ) ) -RRB- cord-355477-7xd93aqv 124 16 . . . cord-355477-7xd93aqv 125 1 27 27 CD cord-355477-7xd93aqv 125 2 CypA CypA NNP cord-355477-7xd93aqv 125 3 is be VBZ cord-355477-7xd93aqv 125 4 a a DT cord-355477-7xd93aqv 125 5 family family NN cord-355477-7xd93aqv 125 6 of of IN cord-355477-7xd93aqv 125 7 proteins protein NNS cord-355477-7xd93aqv 125 8 that that WDT cord-355477-7xd93aqv 125 9 has have VBZ cord-355477-7xd93aqv 125 10 been be VBN cord-355477-7xd93aqv 125 11 extensively extensively RB cord-355477-7xd93aqv 125 12 studied study VBN cord-355477-7xd93aqv 125 13 but but CC cord-355477-7xd93aqv 125 14 their -PRON- PRP$ cord-355477-7xd93aqv 125 15 function function NN cord-355477-7xd93aqv 125 16 remains remain VBZ cord-355477-7xd93aqv 125 17 unknown unknown JJ cord-355477-7xd93aqv 125 18 . . . cord-355477-7xd93aqv 126 1 Recently recently RB cord-355477-7xd93aqv 126 2 , , , cord-355477-7xd93aqv 126 3 cyclophilins cyclophilin NNS cord-355477-7xd93aqv 126 4 have have VBP cord-355477-7xd93aqv 126 5 been be VBN cord-355477-7xd93aqv 126 6 shown show VBN cord-355477-7xd93aqv 126 7 to to TO cord-355477-7xd93aqv 126 8 play play VB cord-355477-7xd93aqv 126 9 an an DT cord-355477-7xd93aqv 126 10 important important JJ cord-355477-7xd93aqv 126 11 role role NN cord-355477-7xd93aqv 126 12 in in IN cord-355477-7xd93aqv 126 13 HIV HIV NNP cord-355477-7xd93aqv 126 14 infection infection NN cord-355477-7xd93aqv 126 15 . . . cord-355477-7xd93aqv 127 1 CypA CypA NNP cord-355477-7xd93aqv 127 2 specifically specifically RB cord-355477-7xd93aqv 127 3 has have VBZ cord-355477-7xd93aqv 127 4 been be VBN cord-355477-7xd93aqv 127 5 shown show VBN cord-355477-7xd93aqv 127 6 to to TO cord-355477-7xd93aqv 127 7 play play VB cord-355477-7xd93aqv 127 8 a a DT cord-355477-7xd93aqv 127 9 vital vital JJ cord-355477-7xd93aqv 127 10 role role NN cord-355477-7xd93aqv 127 11 in in IN cord-355477-7xd93aqv 127 12 viral viral JJ cord-355477-7xd93aqv 127 13 core core NN cord-355477-7xd93aqv 127 14 disassembly disassembly NN cord-355477-7xd93aqv 127 15 . . . cord-355477-7xd93aqv 128 1 28 28 CD cord-355477-7xd93aqv 129 1 Hence hence RB cord-355477-7xd93aqv 129 2 CypA CypA NNP cord-355477-7xd93aqv 129 3 interaction interaction NN cord-355477-7xd93aqv 129 4 with with IN cord-355477-7xd93aqv 129 5 N n CD cord-355477-7xd93aqv 129 6 protein protein NN cord-355477-7xd93aqv 129 7 may may MD cord-355477-7xd93aqv 129 8 provide provide VB cord-355477-7xd93aqv 129 9 new new JJ cord-355477-7xd93aqv 129 10 hints hint NNS cord-355477-7xd93aqv 129 11 about about IN cord-355477-7xd93aqv 129 12 how how WRB cord-355477-7xd93aqv 129 13 SARS SARS NNP cord-355477-7xd93aqv 129 14 CoV CoV NNP cord-355477-7xd93aqv 129 15 infects infect VBZ cord-355477-7xd93aqv 129 16 host host NN cord-355477-7xd93aqv 129 17 cells cell NNS cord-355477-7xd93aqv 129 18 . . . cord-355477-7xd93aqv 130 1 N N NNP cord-355477-7xd93aqv 130 2 protein protein NN cord-355477-7xd93aqv 130 3 has have VBZ cord-355477-7xd93aqv 130 4 also also RB cord-355477-7xd93aqv 130 5 been be VBN cord-355477-7xd93aqv 130 6 reported report VBN cord-355477-7xd93aqv 130 7 to to TO cord-355477-7xd93aqv 130 8 bind bind VB cord-355477-7xd93aqv 130 9 to to IN cord-355477-7xd93aqv 130 10 human human JJ cord-355477-7xd93aqv 130 11 cellular cellular JJ cord-355477-7xd93aqv 130 12 heterogenous heterogenous JJ cord-355477-7xd93aqv 130 13 nuclear nuclear JJ cord-355477-7xd93aqv 130 14 ribonucleoprotein ribonucleoprotein NN cord-355477-7xd93aqv 130 15 A1 A1 NNP cord-355477-7xd93aqv 130 16 ( ( -LRB- cord-355477-7xd93aqv 130 17 hnRNP hnRNP NNP cord-355477-7xd93aqv 130 18 A1 A1 NNP cord-355477-7xd93aqv 130 19 ) ) -RRB- cord-355477-7xd93aqv 130 20 with with IN cord-355477-7xd93aqv 130 21 high high JJ cord-355477-7xd93aqv 130 22 affinity affinity NN cord-355477-7xd93aqv 130 23 . . . cord-355477-7xd93aqv 131 1 29 29 CD cord-355477-7xd93aqv 132 1 The the DT cord-355477-7xd93aqv 132 2 regions region NNS cord-355477-7xd93aqv 132 3 responsible responsible JJ cord-355477-7xd93aqv 132 4 for for IN cord-355477-7xd93aqv 132 5 this this DT cord-355477-7xd93aqv 132 6 protein protein NN cord-355477-7xd93aqv 132 7 - - HYPH cord-355477-7xd93aqv 132 8 protein protein NN cord-355477-7xd93aqv 132 9 interaction interaction NN cord-355477-7xd93aqv 132 10 have have VBP cord-355477-7xd93aqv 132 11 been be VBN cord-355477-7xd93aqv 132 12 shown show VBN cord-355477-7xd93aqv 132 13 to to TO cord-355477-7xd93aqv 132 14 be be VB cord-355477-7xd93aqv 132 15 residing reside VBG cord-355477-7xd93aqv 132 16 in in IN cord-355477-7xd93aqv 132 17 the the DT cord-355477-7xd93aqv 132 18 region region NN cord-355477-7xd93aqv 132 19 from from IN cord-355477-7xd93aqv 132 20 amino amino NN cord-355477-7xd93aqv 132 21 acid acid NN cord-355477-7xd93aqv 132 22 161 161 CD cord-355477-7xd93aqv 132 23 - - SYM cord-355477-7xd93aqv 132 24 210 210 CD cord-355477-7xd93aqv 132 25 of of IN cord-355477-7xd93aqv 132 26 SARS SARS NNP cord-355477-7xd93aqv 132 27 CoV CoV NNP cord-355477-7xd93aqv 132 28 and and CC cord-355477-7xd93aqv 132 29 C C NNP cord-355477-7xd93aqv 132 30 terminus terminus NN cord-355477-7xd93aqv 132 31 amino amino NN cord-355477-7xd93aqv 132 32 acid acid VBP cord-355477-7xd93aqv 132 33 203 203 CD cord-355477-7xd93aqv 132 34 - - SYM cord-355477-7xd93aqv 132 35 320 320 CD cord-355477-7xd93aqv 132 36 of of IN cord-355477-7xd93aqv 132 37 human human JJ cord-355477-7xd93aqv 132 38 hnRNP hnrnp DT cord-355477-7xd93aqv 132 39 A1 a1 NN cord-355477-7xd93aqv 132 40 . . . cord-355477-7xd93aqv 133 1 Studies study NNS cord-355477-7xd93aqv 133 2 have have VBP cord-355477-7xd93aqv 133 3 indicated indicate VBN cord-355477-7xd93aqv 133 4 that that IN cord-355477-7xd93aqv 133 5 hnRNP hnrnp DT cord-355477-7xd93aqv 133 6 A1 a1 NN cord-355477-7xd93aqv 133 7 acts act VBZ cord-355477-7xd93aqv 133 8 as as IN cord-355477-7xd93aqv 133 9 a a DT cord-355477-7xd93aqv 133 10 global global JJ cord-355477-7xd93aqv 133 11 regulator regulator NN cord-355477-7xd93aqv 133 12 of of IN cord-355477-7xd93aqv 133 13 alternative alternative JJ cord-355477-7xd93aqv 133 14 pre pre JJ cord-355477-7xd93aqv 133 15 - - JJ cord-355477-7xd93aqv 133 16 mRNA mrna JJ cord-355477-7xd93aqv 133 17 splicing splicing NN cord-355477-7xd93aqv 133 18 and and CC cord-355477-7xd93aqv 133 19 its -PRON- PRP$ cord-355477-7xd93aqv 133 20 activities activity NNS cord-355477-7xd93aqv 133 21 result result VBP cord-355477-7xd93aqv 133 22 in in IN cord-355477-7xd93aqv 133 23 inactivation inactivation NN cord-355477-7xd93aqv 133 24 of of IN cord-355477-7xd93aqv 133 25 alternative alternative JJ cord-355477-7xd93aqv 133 26 distal distal JJ cord-355477-7xd93aqv 133 27 5 5 CD cord-355477-7xd93aqv 133 28 splicing splicing NN cord-355477-7xd93aqv 133 29 sites site NNS cord-355477-7xd93aqv 133 30 and and CC cord-355477-7xd93aqv 133 31 skipping skipping NN cord-355477-7xd93aqv 133 32 of of IN cord-355477-7xd93aqv 133 33 optional optional JJ cord-355477-7xd93aqv 133 34 exons exon NNS cord-355477-7xd93aqv 133 35 . . . cord-355477-7xd93aqv 134 1 30 30 CD cord-355477-7xd93aqv 135 1 Also also RB cord-355477-7xd93aqv 135 2 a a DT cord-355477-7xd93aqv 135 3 recent recent JJ cord-355477-7xd93aqv 135 4 publication publication NN cord-355477-7xd93aqv 135 5 has have VBZ cord-355477-7xd93aqv 135 6 demonstrated demonstrate VBN cord-355477-7xd93aqv 135 7 that that IN cord-355477-7xd93aqv 135 8 the the DT cord-355477-7xd93aqv 135 9 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 135 10 protein protein NN cord-355477-7xd93aqv 135 11 of of IN cord-355477-7xd93aqv 135 12 MHV MHV NNP cord-355477-7xd93aqv 135 13 could could MD cord-355477-7xd93aqv 135 14 interact interact VB cord-355477-7xd93aqv 135 15 with with IN cord-355477-7xd93aqv 135 16 hnRNP hnrnp DT cord-355477-7xd93aqv 135 17 A1 a1 NN cord-355477-7xd93aqv 135 18 . . . cord-355477-7xd93aqv 136 1 31 31 CD cord-355477-7xd93aqv 137 1 Hence hence RB cord-355477-7xd93aqv 137 2 it -PRON- PRP cord-355477-7xd93aqv 137 3 may may MD cord-355477-7xd93aqv 137 4 be be VB cord-355477-7xd93aqv 137 5 postulated postulate VBN cord-355477-7xd93aqv 137 6 that that IN cord-355477-7xd93aqv 137 7 interaction interaction NN cord-355477-7xd93aqv 137 8 of of IN cord-355477-7xd93aqv 137 9 SARS SARS NNP cord-355477-7xd93aqv 137 10 - - HYPH cord-355477-7xd93aqv 137 11 CoV CoV NNP cord-355477-7xd93aqv 137 12 , , , cord-355477-7xd93aqv 137 13 N N NNP cord-355477-7xd93aqv 137 14 protein protein NN cord-355477-7xd93aqv 137 15 with with IN cord-355477-7xd93aqv 137 16 hnRNP hnrnp DT cord-355477-7xd93aqv 137 17 A1 A1 NNP cord-355477-7xd93aqv 137 18 may may MD cord-355477-7xd93aqv 137 19 play play VB cord-355477-7xd93aqv 137 20 a a DT cord-355477-7xd93aqv 137 21 role role NN cord-355477-7xd93aqv 137 22 in in IN cord-355477-7xd93aqv 137 23 transcription transcription NN cord-355477-7xd93aqv 137 24 and and CC cord-355477-7xd93aqv 137 25 replication replication NN cord-355477-7xd93aqv 137 26 of of IN cord-355477-7xd93aqv 137 27 viral viral JJ cord-355477-7xd93aqv 137 28 genome genome NN cord-355477-7xd93aqv 137 29 . . . cord-355477-7xd93aqv 138 1 Another another DT cord-355477-7xd93aqv 138 2 aspect aspect NN cord-355477-7xd93aqv 138 3 important important JJ cord-355477-7xd93aqv 138 4 for for IN cord-355477-7xd93aqv 138 5 establishing establish VBG cord-355477-7xd93aqv 138 6 an an DT cord-355477-7xd93aqv 138 7 infection infection NN cord-355477-7xd93aqv 138 8 is be VBZ cord-355477-7xd93aqv 138 9 modulation modulation NN cord-355477-7xd93aqv 138 10 of of IN cord-355477-7xd93aqv 138 11 host host NN cord-355477-7xd93aqv 138 12 pathways pathway NNS cord-355477-7xd93aqv 138 13 by by IN cord-355477-7xd93aqv 138 14 viral viral JJ cord-355477-7xd93aqv 138 15 proteins protein NNS cord-355477-7xd93aqv 138 16 . . . cord-355477-7xd93aqv 139 1 A a DT cord-355477-7xd93aqv 139 2 report report NN cord-355477-7xd93aqv 139 3 by by IN cord-355477-7xd93aqv 139 4 He He NNP cord-355477-7xd93aqv 139 5 et et FW cord-355477-7xd93aqv 139 6 al al NNP cord-355477-7xd93aqv 139 7 . . . cord-355477-7xd93aqv 140 1 in in IN cord-355477-7xd93aqv 140 2 2003 2003 CD cord-355477-7xd93aqv 140 3 has have VBZ cord-355477-7xd93aqv 140 4 shown show VBN cord-355477-7xd93aqv 140 5 that that IN cord-355477-7xd93aqv 140 6 N n CD cord-355477-7xd93aqv 140 7 protein protein NN cord-355477-7xd93aqv 140 8 activates activate VBZ cord-355477-7xd93aqv 140 9 AP1 ap1 NN cord-355477-7xd93aqv 140 10 signal signal NN cord-355477-7xd93aqv 140 11 transduction transduction NN cord-355477-7xd93aqv 140 12 pathway pathway NN cord-355477-7xd93aqv 140 13 . . . cord-355477-7xd93aqv 141 1 However however RB cord-355477-7xd93aqv 141 2 , , , cord-355477-7xd93aqv 141 3 the the DT cord-355477-7xd93aqv 141 4 mechanism mechanism NN cord-355477-7xd93aqv 141 5 underlying underlie VBG cord-355477-7xd93aqv 141 6 the the DT cord-355477-7xd93aqv 141 7 observation observation NN cord-355477-7xd93aqv 141 8 is be VBZ cord-355477-7xd93aqv 141 9 not not RB cord-355477-7xd93aqv 141 10 known know VBN cord-355477-7xd93aqv 141 11 yet yet RB cord-355477-7xd93aqv 141 12 . . . cord-355477-7xd93aqv 142 1 Neither neither DT cord-355477-7xd93aqv 142 2 is be VBZ cord-355477-7xd93aqv 142 3 it -PRON- PRP cord-355477-7xd93aqv 142 4 known know VBN cord-355477-7xd93aqv 142 5 whether whether IN cord-355477-7xd93aqv 142 6 N N NNP cord-355477-7xd93aqv 142 7 interacts interact VBZ cord-355477-7xd93aqv 142 8 with with IN cord-355477-7xd93aqv 142 9 the the DT cord-355477-7xd93aqv 142 10 components component NNS cord-355477-7xd93aqv 142 11 of of IN cord-355477-7xd93aqv 142 12 AP1 AP1 NNP cord-355477-7xd93aqv 142 13 directly directly RB cord-355477-7xd93aqv 142 14 or or CC cord-355477-7xd93aqv 142 15 through through IN cord-355477-7xd93aqv 142 16 an an DT cord-355477-7xd93aqv 142 17 intermediate intermediate NN cord-355477-7xd93aqv 142 18 . . . cord-355477-7xd93aqv 143 1 AP1 ap1 NN cord-355477-7xd93aqv 143 2 or or CC cord-355477-7xd93aqv 143 3 activator activator NN cord-355477-7xd93aqv 143 4 protein protein NN cord-355477-7xd93aqv 143 5 1 1 CD cord-355477-7xd93aqv 143 6 pathway pathway NN cord-355477-7xd93aqv 143 7 is be VBZ cord-355477-7xd93aqv 143 8 a a DT cord-355477-7xd93aqv 143 9 regulator regulator NN cord-355477-7xd93aqv 143 10 of of IN cord-355477-7xd93aqv 143 11 a a DT cord-355477-7xd93aqv 143 12 wide wide JJ cord-355477-7xd93aqv 143 13 variety variety NN cord-355477-7xd93aqv 143 14 of of IN cord-355477-7xd93aqv 143 15 cellular cellular JJ cord-355477-7xd93aqv 143 16 processes process NNS cord-355477-7xd93aqv 143 17 . . . cord-355477-7xd93aqv 144 1 These these DT cord-355477-7xd93aqv 144 2 include include VBP cord-355477-7xd93aqv 144 3 cell cell NN cord-355477-7xd93aqv 144 4 proliferation proliferation NN cord-355477-7xd93aqv 144 5 , , , cord-355477-7xd93aqv 144 6 differentiation differentiation NN cord-355477-7xd93aqv 144 7 , , , cord-355477-7xd93aqv 144 8 and and CC cord-355477-7xd93aqv 144 9 apoptosis apoptosis NN cord-355477-7xd93aqv 144 10 . . . cord-355477-7xd93aqv 145 1 This this DT cord-355477-7xd93aqv 145 2 makes make VBZ cord-355477-7xd93aqv 145 3 this this DT cord-355477-7xd93aqv 145 4 pathway pathway NN cord-355477-7xd93aqv 145 5 an an DT cord-355477-7xd93aqv 145 6 important important JJ cord-355477-7xd93aqv 145 7 target target NN cord-355477-7xd93aqv 145 8 for for IN cord-355477-7xd93aqv 145 9 modification modification NN cord-355477-7xd93aqv 145 10 by by IN cord-355477-7xd93aqv 145 11 the the DT cord-355477-7xd93aqv 145 12 viral viral JJ cord-355477-7xd93aqv 145 13 proteins protein NNS cord-355477-7xd93aqv 145 14 to to TO cord-355477-7xd93aqv 145 15 gain gain VB cord-355477-7xd93aqv 145 16 control control NN cord-355477-7xd93aqv 145 17 over over IN cord-355477-7xd93aqv 145 18 the the DT cord-355477-7xd93aqv 145 19 host host NN cord-355477-7xd93aqv 145 20 cell cell NN cord-355477-7xd93aqv 145 21 cycle cycle NN cord-355477-7xd93aqv 145 22 . . . cord-355477-7xd93aqv 146 1 32 32 CD cord-355477-7xd93aqv 147 1 Moreover moreover RB cord-355477-7xd93aqv 147 2 , , , cord-355477-7xd93aqv 147 3 binding bind VBG cord-355477-7xd93aqv 147 4 of of IN cord-355477-7xd93aqv 147 5 N n CD cord-355477-7xd93aqv 147 6 protein protein NN cord-355477-7xd93aqv 147 7 to to IN cord-355477-7xd93aqv 147 8 cyclin cyclin NN cord-355477-7xd93aqv 147 9 - - HYPH cord-355477-7xd93aqv 147 10 dependent dependent JJ cord-355477-7xd93aqv 147 11 kinase kinase NN cord-355477-7xd93aqv 147 12 ( ( -LRB- cord-355477-7xd93aqv 147 13 CDK CDK NNP cord-355477-7xd93aqv 147 14 ) ) -RRB- cord-355477-7xd93aqv 147 15 complex complex JJ cord-355477-7xd93aqv 147 16 leads lead VBZ cord-355477-7xd93aqv 147 17 to to IN cord-355477-7xd93aqv 147 18 downregulation downregulation NN cord-355477-7xd93aqv 147 19 of of IN cord-355477-7xd93aqv 147 20 S s NN cord-355477-7xd93aqv 147 21 phase phase NN cord-355477-7xd93aqv 147 22 gene gene NN cord-355477-7xd93aqv 147 23 products product NNS cord-355477-7xd93aqv 147 24 , , , cord-355477-7xd93aqv 147 25 which which WDT cord-355477-7xd93aqv 147 26 in in IN cord-355477-7xd93aqv 147 27 turn turn NN cord-355477-7xd93aqv 147 28 leads lead VBZ cord-355477-7xd93aqv 147 29 to to IN cord-355477-7xd93aqv 147 30 inhibition inhibition NN cord-355477-7xd93aqv 147 31 of of IN cord-355477-7xd93aqv 147 32 S s NN cord-355477-7xd93aqv 147 33 phase phase NN cord-355477-7xd93aqv 147 34 progression progression NN cord-355477-7xd93aqv 147 35 . . . cord-355477-7xd93aqv 148 1 33 33 CD cord-355477-7xd93aqv 148 2 SARS SARS NNP cord-355477-7xd93aqv 148 3 - - HYPH cord-355477-7xd93aqv 148 4 CoV CoV NNP cord-355477-7xd93aqv 148 5 N n CD cord-355477-7xd93aqv 148 6 protein protein NN cord-355477-7xd93aqv 148 7 has have VBZ cord-355477-7xd93aqv 148 8 also also RB cord-355477-7xd93aqv 148 9 been be VBN cord-355477-7xd93aqv 148 10 shown show VBN cord-355477-7xd93aqv 148 11 to to TO cord-355477-7xd93aqv 148 12 induce induce VB cord-355477-7xd93aqv 148 13 apoptosis apoptosis NN cord-355477-7xd93aqv 148 14 in in IN cord-355477-7xd93aqv 148 15 Cos Cos NNP cord-355477-7xd93aqv 148 16 1 1 CD cord-355477-7xd93aqv 148 17 cells cell NNS cord-355477-7xd93aqv 148 18 . . . cord-355477-7xd93aqv 149 1 Cells cell NNS cord-355477-7xd93aqv 149 2 transfected transfecte VBN cord-355477-7xd93aqv 149 3 with with IN cord-355477-7xd93aqv 149 4 N n CD cord-355477-7xd93aqv 149 5 protein protein NN cord-355477-7xd93aqv 149 6 show show VBP cord-355477-7xd93aqv 149 7 significant significant JJ cord-355477-7xd93aqv 149 8 cell cell NN cord-355477-7xd93aqv 149 9 death death NN cord-355477-7xd93aqv 149 10 under under IN cord-355477-7xd93aqv 149 11 conditions condition NNS cord-355477-7xd93aqv 149 12 of of IN cord-355477-7xd93aqv 149 13 stress stress NN cord-355477-7xd93aqv 149 14 , , , cord-355477-7xd93aqv 149 15 induced induce VBN cord-355477-7xd93aqv 149 16 by by IN cord-355477-7xd93aqv 149 17 serum serum NN cord-355477-7xd93aqv 149 18 starvation starvation NN cord-355477-7xd93aqv 149 19 . . . cord-355477-7xd93aqv 150 1 N N NNP cord-355477-7xd93aqv 150 2 protein protein NN cord-355477-7xd93aqv 150 3 has have VBZ cord-355477-7xd93aqv 150 4 been be VBN cord-355477-7xd93aqv 150 5 found find VBN cord-355477-7xd93aqv 150 6 to to TO cord-355477-7xd93aqv 150 7 downregulate downregulate VB cord-355477-7xd93aqv 150 8 extracellular extracellular JJ cord-355477-7xd93aqv 150 9 signal signal NN cord-355477-7xd93aqv 150 10 - - HYPH cord-355477-7xd93aqv 150 11 regulated regulate VBN cord-355477-7xd93aqv 150 12 kinase kinase NN cord-355477-7xd93aqv 150 13 ( ( -LRB- cord-355477-7xd93aqv 150 14 ERK ERK NNP cord-355477-7xd93aqv 150 15 ) ) -RRB- cord-355477-7xd93aqv 150 16 , , , cord-355477-7xd93aqv 150 17 but but CC cord-355477-7xd93aqv 150 18 upregulate upregulate VB cord-355477-7xd93aqv 150 19 c c NNP cord-355477-7xd93aqv 150 20 - - : cord-355477-7xd93aqv 150 21 jun jun NNP cord-355477-7xd93aqv 150 22 - - HYPH cord-355477-7xd93aqv 150 23 N N NNP cord-355477-7xd93aqv 150 24 - - HYPH cord-355477-7xd93aqv 150 25 terminal terminal NN cord-355477-7xd93aqv 150 26 kinase kinase NN cord-355477-7xd93aqv 150 27 ( ( -LRB- cord-355477-7xd93aqv 150 28 JNK JNK NNP cord-355477-7xd93aqv 150 29 ) ) -RRB- cord-355477-7xd93aqv 150 30 and and CC cord-355477-7xd93aqv 150 31 p38 p38 CD cord-355477-7xd93aqv 150 32 mitogen mitogen NNP cord-355477-7xd93aqv 150 33 - - HYPH cord-355477-7xd93aqv 150 34 activated activate VBN cord-355477-7xd93aqv 150 35 map map NN cord-355477-7xd93aqv 150 36 kinase kinase NN cord-355477-7xd93aqv 150 37 ( ( -LRB- cord-355477-7xd93aqv 150 38 MAPK MAPK NNP cord-355477-7xd93aqv 150 39 ) ) -RRB- cord-355477-7xd93aqv 150 40 . . . cord-355477-7xd93aqv 151 1 Further further RB cord-355477-7xd93aqv 151 2 , , , cord-355477-7xd93aqv 151 3 p38 p38 CD cord-355477-7xd93aqv 151 4 MAPK MAPK NNP cord-355477-7xd93aqv 151 5 activation activation NN cord-355477-7xd93aqv 151 6 was be VBD cord-355477-7xd93aqv 151 7 also also RB cord-355477-7xd93aqv 151 8 found find VBN cord-355477-7xd93aqv 151 9 to to TO cord-355477-7xd93aqv 151 10 induce induce VB cord-355477-7xd93aqv 151 11 actin actin NN cord-355477-7xd93aqv 151 12 reorganization reorganization NN cord-355477-7xd93aqv 151 13 . . . cord-355477-7xd93aqv 152 1 34 34 CD cord-355477-7xd93aqv 152 2 Nucleocapsid Nucleocapsid NNP cord-355477-7xd93aqv 152 3 protein protein NN cord-355477-7xd93aqv 152 4 of of IN cord-355477-7xd93aqv 152 5 several several JJ cord-355477-7xd93aqv 152 6 CoVs CoVs NNP cord-355477-7xd93aqv 152 7 exhibits exhibit NNS cord-355477-7xd93aqv 152 8 cytoplasmic cytoplasmic JJ cord-355477-7xd93aqv 152 9 as as RB cord-355477-7xd93aqv 152 10 well well RB cord-355477-7xd93aqv 152 11 as as IN cord-355477-7xd93aqv 152 12 nucleolar nucleolar JJ cord-355477-7xd93aqv 152 13 localization localization NN cord-355477-7xd93aqv 152 14 at at IN cord-355477-7xd93aqv 152 15 some some DT cord-355477-7xd93aqv 152 16 point point NN cord-355477-7xd93aqv 152 17 of of IN cord-355477-7xd93aqv 152 18 time time NN cord-355477-7xd93aqv 152 19 during during IN cord-355477-7xd93aqv 152 20 the the DT cord-355477-7xd93aqv 152 21 infection infection NN cord-355477-7xd93aqv 152 22 cycle cycle NN cord-355477-7xd93aqv 152 23 . . . cord-355477-7xd93aqv 153 1 In in IN cord-355477-7xd93aqv 153 2 the the DT cord-355477-7xd93aqv 153 3 case case NN cord-355477-7xd93aqv 153 4 of of IN cord-355477-7xd93aqv 153 5 SARS SARS NNP cord-355477-7xd93aqv 153 6 - - HYPH cord-355477-7xd93aqv 153 7 CoV CoV NNP cord-355477-7xd93aqv 153 8 , , , cord-355477-7xd93aqv 153 9 the the DT cord-355477-7xd93aqv 153 10 N N NNP cord-355477-7xd93aqv 153 11 protein protein NN cord-355477-7xd93aqv 153 12 had have VBD cord-355477-7xd93aqv 153 13 been be VBN cord-355477-7xd93aqv 153 14 predicted predict VBN cord-355477-7xd93aqv 153 15 to to TO cord-355477-7xd93aqv 153 16 contain contain VB cord-355477-7xd93aqv 153 17 as as RB cord-355477-7xd93aqv 153 18 many many JJ cord-355477-7xd93aqv 153 19 as as IN cord-355477-7xd93aqv 153 20 eight eight CD cord-355477-7xd93aqv 153 21 nuclear nuclear JJ cord-355477-7xd93aqv 153 22 localization localization NN cord-355477-7xd93aqv 153 23 signal signal NN cord-355477-7xd93aqv 153 24 ( ( -LRB- cord-355477-7xd93aqv 153 25 NLS NLS NNP cord-355477-7xd93aqv 153 26 ) ) -RRB- cord-355477-7xd93aqv 153 27 motifs motif NNS cord-355477-7xd93aqv 153 28 , , , cord-355477-7xd93aqv 153 29 both both DT cord-355477-7xd93aqv 153 30 monopartite monopartite JJ cord-355477-7xd93aqv 153 31 and and CC cord-355477-7xd93aqv 153 32 bipartite bipartite JJ cord-355477-7xd93aqv 153 33 . . . cord-355477-7xd93aqv 154 1 A a DT cord-355477-7xd93aqv 154 2 report report NN cord-355477-7xd93aqv 154 3 by by IN cord-355477-7xd93aqv 154 4 Zhu Zhu NNP cord-355477-7xd93aqv 154 5 et et FW cord-355477-7xd93aqv 154 6 al al NNP cord-355477-7xd93aqv 154 7 . . . cord-355477-7xd93aqv 155 1 35 35 CD cord-355477-7xd93aqv 155 2 showed show VBD cord-355477-7xd93aqv 155 3 that that IN cord-355477-7xd93aqv 155 4 the the DT cord-355477-7xd93aqv 155 5 wild wild JJ cord-355477-7xd93aqv 155 6 - - HYPH cord-355477-7xd93aqv 155 7 type type NN cord-355477-7xd93aqv 155 8 N N NNP cord-355477-7xd93aqv 155 9 was be VBD cord-355477-7xd93aqv 155 10 distributed distribute VBN cord-355477-7xd93aqv 155 11 mainly mainly RB cord-355477-7xd93aqv 155 12 in in IN cord-355477-7xd93aqv 155 13 the the DT cord-355477-7xd93aqv 155 14 cytoplasm cytoplasm NN cord-355477-7xd93aqv 155 15 . . . cord-355477-7xd93aqv 156 1 The the DT cord-355477-7xd93aqv 156 2 N N NNP cord-355477-7xd93aqv 156 3 - - HYPH cord-355477-7xd93aqv 156 4 terminal terminal NN cord-355477-7xd93aqv 156 5 of of IN cord-355477-7xd93aqv 156 6 N N NNP cord-355477-7xd93aqv 156 7 , , , cord-355477-7xd93aqv 156 8 which which WDT cord-355477-7xd93aqv 156 9 contains contain VBZ cord-355477-7xd93aqv 156 10 the the DT cord-355477-7xd93aqv 156 11 NLS1 NLS1 NNP cord-355477-7xd93aqv 156 12 ( ( -LRB- cord-355477-7xd93aqv 156 13 aa38 aa38 NN cord-355477-7xd93aqv 156 14 - - HYPH cord-355477-7xd93aqv 156 15 44 44 CD cord-355477-7xd93aqv 156 16 ) ) -RRB- cord-355477-7xd93aqv 156 17 , , , cord-355477-7xd93aqv 156 18 was be VBD cord-355477-7xd93aqv 156 19 localized localize VBN cord-355477-7xd93aqv 156 20 to to IN cord-355477-7xd93aqv 156 21 the the DT cord-355477-7xd93aqv 156 22 nucleus nucleus NN cord-355477-7xd93aqv 156 23 . . . cord-355477-7xd93aqv 157 1 The the DT cord-355477-7xd93aqv 157 2 C C NNP cord-355477-7xd93aqv 157 3 terminus terminus NN cord-355477-7xd93aqv 157 4 of of IN cord-355477-7xd93aqv 157 5 N N NNP cord-355477-7xd93aqv 157 6 , , , cord-355477-7xd93aqv 157 7 which which WDT cord-355477-7xd93aqv 157 8 contains contain VBZ cord-355477-7xd93aqv 157 9 both both DT cord-355477-7xd93aqv 157 10 NLS2 NLS2 NNP cord-355477-7xd93aqv 157 11 ( ( -LRB- cord-355477-7xd93aqv 157 12 aa257 aa257 NNP cord-355477-7xd93aqv 157 13 - - HYPH cord-355477-7xd93aqv 157 14 265 265 CD cord-355477-7xd93aqv 157 15 ) ) -RRB- cord-355477-7xd93aqv 157 16 and and CC cord-355477-7xd93aqv 157 17 NLS3 NLS3 NNP cord-355477-7xd93aqv 157 18 ( ( -LRB- cord-355477-7xd93aqv 157 19 aa369 aa369 NNP cord-355477-7xd93aqv 157 20 - - HYPH cord-355477-7xd93aqv 157 21 390 390 CD cord-355477-7xd93aqv 157 22 ) ) -RRB- cord-355477-7xd93aqv 157 23 , , , cord-355477-7xd93aqv 157 24 was be VBD cord-355477-7xd93aqv 157 25 localized localize VBN cord-355477-7xd93aqv 157 26 to to IN cord-355477-7xd93aqv 157 27 the the DT cord-355477-7xd93aqv 157 28 cytoplasm cytoplasm NN cord-355477-7xd93aqv 157 29 and and CC cord-355477-7xd93aqv 157 30 the the DT cord-355477-7xd93aqv 157 31 nucleolus nucleolus NN cord-355477-7xd93aqv 157 32 . . . cord-355477-7xd93aqv 158 1 Also also RB cord-355477-7xd93aqv 158 2 the the DT cord-355477-7xd93aqv 158 3 region region NN cord-355477-7xd93aqv 158 4 containing contain VBG cord-355477-7xd93aqv 158 5 amino amino JJ cord-355477-7xd93aqv 158 6 acids acid NNS cord-355477-7xd93aqv 158 7 226 226 CD cord-355477-7xd93aqv 158 8 - - HYPH cord-355477-7xd93aqv 158 9 289 289 CD cord-355477-7xd93aqv 158 10 was be VBD cord-355477-7xd93aqv 158 11 able able JJ cord-355477-7xd93aqv 158 12 to to TO cord-355477-7xd93aqv 158 13 mediate mediate VB cord-355477-7xd93aqv 158 14 nucleolar nucleolar JJ cord-355477-7xd93aqv 158 15 localization localization NN cord-355477-7xd93aqv 158 16 . . . cord-355477-7xd93aqv 159 1 Furthermore furthermore RB cord-355477-7xd93aqv 159 2 , , , cord-355477-7xd93aqv 159 3 deletion deletion NN cord-355477-7xd93aqv 159 4 of of IN cord-355477-7xd93aqv 159 5 the the DT cord-355477-7xd93aqv 159 6 leucine leucine NN cord-355477-7xd93aqv 159 7 - - HYPH cord-355477-7xd93aqv 159 8 rich rich JJ cord-355477-7xd93aqv 159 9 region region NN cord-355477-7xd93aqv 159 10 ( ( -LRB- cord-355477-7xd93aqv 159 11 220-LALLLLDRLNRL 220-lalllldrlnrl CD cord-355477-7xd93aqv 159 12 ) ) -RRB- cord-355477-7xd93aqv 159 13 resulted result VBD cord-355477-7xd93aqv 159 14 in in IN cord-355477-7xd93aqv 159 15 the the DT cord-355477-7xd93aqv 159 16 accumulation accumulation NN cord-355477-7xd93aqv 159 17 of of IN cord-355477-7xd93aqv 159 18 N n CD cord-355477-7xd93aqv 159 19 to to IN cord-355477-7xd93aqv 159 20 the the DT cord-355477-7xd93aqv 159 21 cytoplasm cytoplasm NN cord-355477-7xd93aqv 159 22 and and CC cord-355477-7xd93aqv 159 23 nucleolus nucleolus NN cord-355477-7xd93aqv 159 24 , , , cord-355477-7xd93aqv 159 25 and and CC cord-355477-7xd93aqv 159 26 when when WRB cord-355477-7xd93aqv 159 27 fusing fuse VBG cord-355477-7xd93aqv 159 28 this this DT cord-355477-7xd93aqv 159 29 peptide peptide NN cord-355477-7xd93aqv 159 30 to to IN cord-355477-7xd93aqv 159 31 enhanced enhance VBN cord-355477-7xd93aqv 159 32 green green JJ cord-355477-7xd93aqv 159 33 fluorescence fluorescence NN cord-355477-7xd93aqv 159 34 protein protein NN cord-355477-7xd93aqv 159 35 ( ( -LRB- cord-355477-7xd93aqv 159 36 EGFP EGFP NNP cord-355477-7xd93aqv 159 37 ) ) -RRB- cord-355477-7xd93aqv 159 38 localization localization NN cord-355477-7xd93aqv 159 39 was be VBD cord-355477-7xd93aqv 159 40 cytoplasmic cytoplasmic JJ cord-355477-7xd93aqv 159 41 , , , cord-355477-7xd93aqv 159 42 suggesting suggest VBG cord-355477-7xd93aqv 159 43 that that IN cord-355477-7xd93aqv 159 44 N N NNP cord-355477-7xd93aqv 159 45 may may MD cord-355477-7xd93aqv 159 46 act act VB cord-355477-7xd93aqv 159 47 as as IN cord-355477-7xd93aqv 159 48 a a DT cord-355477-7xd93aqv 159 49 shuttle shuttle NN cord-355477-7xd93aqv 159 50 protein protein NN cord-355477-7xd93aqv 159 51 . . . cord-355477-7xd93aqv 160 1 35 35 CD cord-355477-7xd93aqv 161 1 A a DT cord-355477-7xd93aqv 161 2 report report NN cord-355477-7xd93aqv 161 3 by by IN cord-355477-7xd93aqv 161 4 Surjit Surjit NNP cord-355477-7xd93aqv 161 5 et et NNP cord-355477-7xd93aqv 161 6 al al NNP cord-355477-7xd93aqv 161 7 . . . cord-355477-7xd93aqv 162 1 ( ( -LRB- cord-355477-7xd93aqv 162 2 2005 2005 CD cord-355477-7xd93aqv 162 3 ) ) -RRB- cord-355477-7xd93aqv 162 4 provides provide VBZ cord-355477-7xd93aqv 162 5 evidence evidence NN cord-355477-7xd93aqv 162 6 that that IN cord-355477-7xd93aqv 162 7 N n NN cord-355477-7xd93aqv 162 8 is be VBZ cord-355477-7xd93aqv 162 9 indeed indeed RB cord-355477-7xd93aqv 162 10 a a DT cord-355477-7xd93aqv 162 11 nucleocytoplasmic nucleocytoplasmic NN cord-355477-7xd93aqv 162 12 - - HYPH cord-355477-7xd93aqv 162 13 shuttling shuttle VBG cord-355477-7xd93aqv 162 14 protein protein NN cord-355477-7xd93aqv 162 15 . . . cord-355477-7xd93aqv 163 1 36 36 CD cord-355477-7xd93aqv 163 2 N n CD cord-355477-7xd93aqv 163 3 proteins protein NNS cord-355477-7xd93aqv 163 4 of of IN cord-355477-7xd93aqv 163 5 many many JJ cord-355477-7xd93aqv 163 6 CoVs cov NNS cord-355477-7xd93aqv 163 7 have have VBP cord-355477-7xd93aqv 163 8 been be VBN cord-355477-7xd93aqv 163 9 shown show VBN cord-355477-7xd93aqv 163 10 to to TO cord-355477-7xd93aqv 163 11 be be VB cord-355477-7xd93aqv 163 12 phosphorylated phosphorylate VBN cord-355477-7xd93aqv 163 13 . . . cord-355477-7xd93aqv 164 1 37 37 CD cord-355477-7xd93aqv 165 1 How how WRB cord-355477-7xd93aqv 165 2 - - : cord-355477-7xd93aqv 165 3 ever ever RB cord-355477-7xd93aqv 165 4 , , , cord-355477-7xd93aqv 165 5 the the DT cord-355477-7xd93aqv 165 6 mechanism mechanism NN cord-355477-7xd93aqv 165 7 by by IN cord-355477-7xd93aqv 165 8 which which WDT cord-355477-7xd93aqv 165 9 this this DT cord-355477-7xd93aqv 165 10 happens happen VBZ cord-355477-7xd93aqv 165 11 and and CC cord-355477-7xd93aqv 165 12 the the DT cord-355477-7xd93aqv 165 13 functional functional JJ cord-355477-7xd93aqv 165 14 significance significance NN cord-355477-7xd93aqv 165 15 of of IN cord-355477-7xd93aqv 165 16 this this DT cord-355477-7xd93aqv 165 17 process process NN cord-355477-7xd93aqv 165 18 remains remain VBZ cord-355477-7xd93aqv 165 19 largely largely RB cord-355477-7xd93aqv 165 20 unknown unknown JJ cord-355477-7xd93aqv 165 21 . . . cord-355477-7xd93aqv 166 1 N n CD cord-355477-7xd93aqv 166 2 protein protein NN cord-355477-7xd93aqv 166 3 of of IN cord-355477-7xd93aqv 166 4 SARS SARS NNP cord-355477-7xd93aqv 166 5 - - HYPH cord-355477-7xd93aqv 166 6 CoV CoV NNP cord-355477-7xd93aqv 166 7 has have VBZ cord-355477-7xd93aqv 166 8 been be VBN cord-355477-7xd93aqv 166 9 shown show VBN cord-355477-7xd93aqv 166 10 to to TO cord-355477-7xd93aqv 166 11 be be VB cord-355477-7xd93aqv 166 12 a a DT cord-355477-7xd93aqv 166 13 phosphoprotein phosphoprotein NN cord-355477-7xd93aqv 166 14 , , , cord-355477-7xd93aqv 166 15 which which WDT cord-355477-7xd93aqv 166 16 is be VBZ cord-355477-7xd93aqv 166 17 stable stable JJ cord-355477-7xd93aqv 166 18 and and CC cord-355477-7xd93aqv 166 19 localizes localize VBZ cord-355477-7xd93aqv 166 20 in in IN cord-355477-7xd93aqv 166 21 the the DT cord-355477-7xd93aqv 166 22 cytoplasm cytoplasm NN cord-355477-7xd93aqv 166 23 . . . cord-355477-7xd93aqv 167 1 The the DT cord-355477-7xd93aqv 167 2 phosphorylation phosphorylation NN cord-355477-7xd93aqv 167 3 takes take VBZ cord-355477-7xd93aqv 167 4 place place NN cord-355477-7xd93aqv 167 5 at at IN cord-355477-7xd93aqv 167 6 the the DT cord-355477-7xd93aqv 167 7 serine serine NN cord-355477-7xd93aqv 167 8 residues residue NNS cord-355477-7xd93aqv 167 9 and and CC cord-355477-7xd93aqv 167 10 that that IN cord-355477-7xd93aqv 167 11 too too RB cord-355477-7xd93aqv 167 12 by by IN cord-355477-7xd93aqv 167 13 multiple multiple JJ cord-355477-7xd93aqv 167 14 kinases kinase NNS cord-355477-7xd93aqv 167 15 . . . cord-355477-7xd93aqv 168 1 It -PRON- PRP cord-355477-7xd93aqv 168 2 has have VBZ cord-355477-7xd93aqv 168 3 been be VBN cord-355477-7xd93aqv 168 4 shown show VBN cord-355477-7xd93aqv 168 5 to to TO cord-355477-7xd93aqv 168 6 be be VB cord-355477-7xd93aqv 168 7 a a DT cord-355477-7xd93aqv 168 8 substrate substrate NN cord-355477-7xd93aqv 168 9 for for IN cord-355477-7xd93aqv 168 10 CDK CDK NNP cord-355477-7xd93aqv 168 11 , , , cord-355477-7xd93aqv 168 12 glycogen glycogen NN cord-355477-7xd93aqv 168 13 synthase synthase NN cord-355477-7xd93aqv 168 14 kinase kinase NN cord-355477-7xd93aqv 168 15 , , , cord-355477-7xd93aqv 168 16 MAPK MAPK NNP cord-355477-7xd93aqv 168 17 , , , cord-355477-7xd93aqv 168 18 and and CC cord-355477-7xd93aqv 168 19 casein casein NN cord-355477-7xd93aqv 168 20 kinase kinase NN cord-355477-7xd93aqv 168 21 II II NNP cord-355477-7xd93aqv 168 22 . . . cord-355477-7xd93aqv 169 1 A a DT cord-355477-7xd93aqv 169 2 possible possible JJ cord-355477-7xd93aqv 169 3 mechanism mechanism NN cord-355477-7xd93aqv 169 4 for for IN cord-355477-7xd93aqv 169 5 phosphorylation phosphorylation NN cord-355477-7xd93aqv 169 6 - - HYPH cord-355477-7xd93aqv 169 7 dependent dependent JJ cord-355477-7xd93aqv 169 8 nucleocytoplasmic nucleocytoplasmic NN cord-355477-7xd93aqv 169 9 shuttling shuttle VBG cord-355477-7xd93aqv 169 10 of of IN cord-355477-7xd93aqv 169 11 the the DT cord-355477-7xd93aqv 169 12 N N NNP cord-355477-7xd93aqv 169 13 protein protein NN cord-355477-7xd93aqv 169 14 has have VBZ cord-355477-7xd93aqv 169 15 also also RB cord-355477-7xd93aqv 169 16 been be VBN cord-355477-7xd93aqv 169 17 elucidated elucidate VBN cord-355477-7xd93aqv 169 18 . . . cord-355477-7xd93aqv 170 1 It -PRON- PRP cord-355477-7xd93aqv 170 2 has have VBZ cord-355477-7xd93aqv 170 3 been be VBN cord-355477-7xd93aqv 170 4 shown show VBN cord-355477-7xd93aqv 170 5 that that IN cord-355477-7xd93aqv 170 6 phosphorylated phosphorylated JJ cord-355477-7xd93aqv 170 7 N N NNP cord-355477-7xd93aqv 170 8 is be VBZ cord-355477-7xd93aqv 170 9 translocated translocate VBN cord-355477-7xd93aqv 170 10 to to TO cord-355477-7xd93aqv 170 11 cytoplasm cytoplasm VB cord-355477-7xd93aqv 170 12 with with IN cord-355477-7xd93aqv 170 13 the the DT cord-355477-7xd93aqv 170 14 help help NN cord-355477-7xd93aqv 170 15 of of IN cord-355477-7xd93aqv 170 16 14 14 CD cord-355477-7xd93aqv 170 17 - - SYM cord-355477-7xd93aqv 170 18 3 3 CD cord-355477-7xd93aqv 170 19 - - SYM cord-355477-7xd93aqv 170 20 3 3 CD cord-355477-7xd93aqv 170 21 ( ( -LRB- cord-355477-7xd93aqv 170 22 tyrosine tyrosine NN cord-355477-7xd93aqv 170 23 3-monooxygenase 3-monooxygenase CD cord-355477-7xd93aqv 170 24 / / SYM cord-355477-7xd93aqv 170 25 tryptophan tryptophan NN cord-355477-7xd93aqv 170 26 5-monooxygenase 5-monooxygenase CD cord-355477-7xd93aqv 170 27 activation activation NN cord-355477-7xd93aqv 170 28 protein protein NN cord-355477-7xd93aqv 170 29 ) ) -RRB- cord-355477-7xd93aqv 170 30 , , , cord-355477-7xd93aqv 170 31 a a DT cord-355477-7xd93aqv 170 32 protein protein NN cord-355477-7xd93aqv 170 33 family family NN cord-355477-7xd93aqv 170 34 that that WDT cord-355477-7xd93aqv 170 35 functions function VBZ cord-355477-7xd93aqv 170 36 as as IN cord-355477-7xd93aqv 170 37 adapters adapter NNS cord-355477-7xd93aqv 170 38 for for IN cord-355477-7xd93aqv 170 39 modulating modulate VBG cord-355477-7xd93aqv 170 40 interactions interaction NNS cord-355477-7xd93aqv 170 41 between between IN cord-355477-7xd93aqv 170 42 components component NNS cord-355477-7xd93aqv 170 43 of of IN cord-355477-7xd93aqv 170 44 various various JJ cord-355477-7xd93aqv 170 45 cellular cellular JJ cord-355477-7xd93aqv 170 46 signaling signaling NN cord-355477-7xd93aqv 170 47 and and CC cord-355477-7xd93aqv 170 48 cell cell NN cord-355477-7xd93aqv 170 49 - - HYPH cord-355477-7xd93aqv 170 50 cycle cycle NN cord-355477-7xd93aqv 170 51 regulatory regulatory JJ cord-355477-7xd93aqv 170 52 pathways pathway NNS cord-355477-7xd93aqv 170 53 through through IN cord-355477-7xd93aqv 170 54 phosphorylationdependent phosphorylationdependent NN cord-355477-7xd93aqv 170 55 protein protein NN cord-355477-7xd93aqv 170 56 - - HYPH cord-355477-7xd93aqv 170 57 protein protein NN cord-355477-7xd93aqv 170 58 interactions interaction NNS cord-355477-7xd93aqv 170 59 . . . cord-355477-7xd93aqv 171 1 36 36 CD cord-355477-7xd93aqv 172 1 It -PRON- PRP cord-355477-7xd93aqv 172 2 can can MD cord-355477-7xd93aqv 172 3 be be VB cord-355477-7xd93aqv 172 4 postulated postulate VBN cord-355477-7xd93aqv 172 5 that that IN cord-355477-7xd93aqv 172 6 N n CD cord-355477-7xd93aqv 172 7 phosphorylation phosphorylation NN cord-355477-7xd93aqv 172 8 may may MD cord-355477-7xd93aqv 172 9 be be VB cord-355477-7xd93aqv 172 10 serving serve VBG cord-355477-7xd93aqv 172 11 an an DT cord-355477-7xd93aqv 172 12 array array NN cord-355477-7xd93aqv 172 13 of of IN cord-355477-7xd93aqv 172 14 purposes purpose NNS cord-355477-7xd93aqv 172 15 ranging range VBG cord-355477-7xd93aqv 172 16 from from IN cord-355477-7xd93aqv 172 17 acting act VBG cord-355477-7xd93aqv 172 18 as as IN cord-355477-7xd93aqv 172 19 a a DT cord-355477-7xd93aqv 172 20 deciding decide VBG cord-355477-7xd93aqv 172 21 factor factor NN cord-355477-7xd93aqv 172 22 for for IN cord-355477-7xd93aqv 172 23 localization localization NN cord-355477-7xd93aqv 172 24 of of IN cord-355477-7xd93aqv 172 25 protein protein NN cord-355477-7xd93aqv 172 26 to to IN cord-355477-7xd93aqv 172 27 aiding aid VBG cord-355477-7xd93aqv 172 28 in in IN cord-355477-7xd93aqv 172 29 creating create VBG cord-355477-7xd93aqv 172 30 a a DT cord-355477-7xd93aqv 172 31 more more RBR cord-355477-7xd93aqv 172 32 favorable favorable JJ cord-355477-7xd93aqv 172 33 environment environment NN cord-355477-7xd93aqv 172 34 for for IN cord-355477-7xd93aqv 172 35 replication replication NN cord-355477-7xd93aqv 172 36 of of IN cord-355477-7xd93aqv 172 37 the the DT cord-355477-7xd93aqv 172 38 virus virus NN cord-355477-7xd93aqv 172 39 . . . cord-355477-7xd93aqv 173 1 36 36 CD cord-355477-7xd93aqv 173 2 CoV cov NN cord-355477-7xd93aqv 173 3 matrix matrix NN cord-355477-7xd93aqv 173 4 ( ( -LRB- cord-355477-7xd93aqv 173 5 M M NNP cord-355477-7xd93aqv 173 6 ) ) -RRB- cord-355477-7xd93aqv 173 7 protein protein NN cord-355477-7xd93aqv 173 8 is be VBZ cord-355477-7xd93aqv 173 9 the the DT cord-355477-7xd93aqv 173 10 most most RBS cord-355477-7xd93aqv 173 11 abundant abundant JJ cord-355477-7xd93aqv 173 12 structural structural JJ cord-355477-7xd93aqv 173 13 protein protein NN cord-355477-7xd93aqv 173 14 at at IN cord-355477-7xd93aqv 173 15 the the DT cord-355477-7xd93aqv 173 16 surface surface NN cord-355477-7xd93aqv 173 17 of of IN cord-355477-7xd93aqv 173 18 virus virus NN cord-355477-7xd93aqv 173 19 particles particle NNS cord-355477-7xd93aqv 173 20 and and CC cord-355477-7xd93aqv 173 21 contains contain VBZ cord-355477-7xd93aqv 173 22 three three CD cord-355477-7xd93aqv 173 23 putative putative JJ cord-355477-7xd93aqv 173 24 transmembrane transmembrane NN cord-355477-7xd93aqv 173 25 domains domain NNS cord-355477-7xd93aqv 173 26 , , , cord-355477-7xd93aqv 173 27 a a DT cord-355477-7xd93aqv 173 28 short short JJ cord-355477-7xd93aqv 173 29 N n CD cord-355477-7xd93aqv 173 30 - - HYPH cord-355477-7xd93aqv 173 31 terminal terminal NN cord-355477-7xd93aqv 173 32 ectodomain ectodomain NN cord-355477-7xd93aqv 173 33 , , , cord-355477-7xd93aqv 173 34 and and CC cord-355477-7xd93aqv 173 35 a a DT cord-355477-7xd93aqv 173 36 long long JJ cord-355477-7xd93aqv 173 37 C c NN cord-355477-7xd93aqv 173 38 - - HYPH cord-355477-7xd93aqv 173 39 terminal terminal NN cord-355477-7xd93aqv 173 40 endodomain endodomain NN cord-355477-7xd93aqv 173 41 . . . cord-355477-7xd93aqv 174 1 Interaction interaction NN cord-355477-7xd93aqv 174 2 of of IN cord-355477-7xd93aqv 174 3 the the DT cord-355477-7xd93aqv 174 4 M M NNP cord-355477-7xd93aqv 174 5 protein protein NN cord-355477-7xd93aqv 174 6 with with IN cord-355477-7xd93aqv 174 7 N N NNP cord-355477-7xd93aqv 174 8 has have VBZ cord-355477-7xd93aqv 174 9 been be VBN cord-355477-7xd93aqv 174 10 described describe VBN cord-355477-7xd93aqv 174 11 for for IN cord-355477-7xd93aqv 174 12 many many JJ cord-355477-7xd93aqv 174 13 CoVs CoVs NNP cord-355477-7xd93aqv 174 14 . . . cord-355477-7xd93aqv 175 1 For for IN cord-355477-7xd93aqv 175 2 SARS SARS NNP cord-355477-7xd93aqv 175 3 - - HYPH cord-355477-7xd93aqv 175 4 CoV CoV NNP cord-355477-7xd93aqv 175 5 , , , cord-355477-7xd93aqv 175 6 the the DT cord-355477-7xd93aqv 175 7 M M NNP cord-355477-7xd93aqv 175 8 - - HYPH cord-355477-7xd93aqv 175 9 N N NNP cord-355477-7xd93aqv 175 10 interaction interaction NN cord-355477-7xd93aqv 175 11 was be VBD cord-355477-7xd93aqv 175 12 first first RB cord-355477-7xd93aqv 175 13 reported report VBN cord-355477-7xd93aqv 175 14 by by IN cord-355477-7xd93aqv 175 15 Fang Fang NNP cord-355477-7xd93aqv 175 16 et et FW cord-355477-7xd93aqv 175 17 al al NNP cord-355477-7xd93aqv 175 18 . . . cord-355477-7xd93aqv 176 1 ( ( -LRB- cord-355477-7xd93aqv 176 2 2005 2005 CD cord-355477-7xd93aqv 176 3 ) ) -RRB- cord-355477-7xd93aqv 176 4 using use VBG cord-355477-7xd93aqv 176 5 glutathione glutathione NN cord-355477-7xd93aqv 176 6 - - HYPH cord-355477-7xd93aqv 176 7 S s NN cord-355477-7xd93aqv 176 8 - - HYPH cord-355477-7xd93aqv 176 9 transferase transferase NN cord-355477-7xd93aqv 176 10 pulldowns pulldown NNS cord-355477-7xd93aqv 176 11 . . . cord-355477-7xd93aqv 177 1 Laboratory laboratory NN cord-355477-7xd93aqv 177 2 experiments experiment NNS cord-355477-7xd93aqv 177 3 have have VBP cord-355477-7xd93aqv 177 4 shown show VBN cord-355477-7xd93aqv 177 5 that that IN cord-355477-7xd93aqv 177 6 the the DT cord-355477-7xd93aqv 177 7 12 12 CD cord-355477-7xd93aqv 177 8 amino amino JJ cord-355477-7xd93aqv 177 9 acids acid NNS cord-355477-7xd93aqv 177 10 domain domain NN cord-355477-7xd93aqv 177 11 ( ( -LRB- cord-355477-7xd93aqv 177 12 194 194 CD cord-355477-7xd93aqv 177 13 ) ) -RRB- cord-355477-7xd93aqv 177 14 ( ( -LRB- cord-355477-7xd93aqv 177 15 195 195 CD cord-355477-7xd93aqv 177 16 ) ) -RRB- cord-355477-7xd93aqv 177 17 ( ( -LRB- cord-355477-7xd93aqv 177 18 196 196 CD cord-355477-7xd93aqv 177 19 ) ) -RRB- cord-355477-7xd93aqv 177 20 ( ( -LRB- cord-355477-7xd93aqv 177 21 197 197 CD cord-355477-7xd93aqv 177 22 ) ) -RRB- cord-355477-7xd93aqv 177 23 ( ( -LRB- cord-355477-7xd93aqv 177 24 198 198 CD cord-355477-7xd93aqv 177 25 ) ) -RRB- cord-355477-7xd93aqv 177 26 ( ( -LRB- cord-355477-7xd93aqv 177 27 199 199 CD cord-355477-7xd93aqv 177 28 ) ) -RRB- cord-355477-7xd93aqv 177 29 ( ( -LRB- cord-355477-7xd93aqv 177 30 200 200 CD cord-355477-7xd93aqv 177 31 ) ) -RRB- cord-355477-7xd93aqv 177 32 ( ( -LRB- cord-355477-7xd93aqv 177 33 201 201 CD cord-355477-7xd93aqv 177 34 ) ) -RRB- cord-355477-7xd93aqv 177 35 ( ( -LRB- cord-355477-7xd93aqv 177 36 202 202 CD cord-355477-7xd93aqv 177 37 ) ) -RRB- cord-355477-7xd93aqv 177 38 ( ( -LRB- cord-355477-7xd93aqv 177 39 203 203 CD cord-355477-7xd93aqv 177 40 ) ) -RRB- cord-355477-7xd93aqv 177 41 ( ( -LRB- cord-355477-7xd93aqv 177 42 204 204 CD cord-355477-7xd93aqv 177 43 ) ) -RRB- cord-355477-7xd93aqv 177 44 ( ( -LRB- cord-355477-7xd93aqv 177 45 205 205 CD cord-355477-7xd93aqv 177 46 ) ) -RRB- cord-355477-7xd93aqv 177 47 in in IN cord-355477-7xd93aqv 177 48 the the DT cord-355477-7xd93aqv 177 49 M M NNP cord-355477-7xd93aqv 177 50 protein protein NN cord-355477-7xd93aqv 177 51 is be VBZ cord-355477-7xd93aqv 177 52 responsible responsible JJ cord-355477-7xd93aqv 177 53 for for IN cord-355477-7xd93aqv 177 54 binding bind VBG cord-355477-7xd93aqv 177 55 to to IN cord-355477-7xd93aqv 177 56 the the DT cord-355477-7xd93aqv 177 57 N n CD cord-355477-7xd93aqv 177 58 protein protein NN cord-355477-7xd93aqv 177 59 . . . cord-355477-7xd93aqv 178 1 39 39 CD cord-355477-7xd93aqv 178 2 Linear Linear NNP cord-355477-7xd93aqv 178 3 epitope epitope NN cord-355477-7xd93aqv 178 4 mapping mapping NN cord-355477-7xd93aqv 178 5 of of IN cord-355477-7xd93aqv 178 6 the the DT cord-355477-7xd93aqv 178 7 M M NNP cord-355477-7xd93aqv 178 8 protein protein NN cord-355477-7xd93aqv 178 9 using use VBG cord-355477-7xd93aqv 178 10 synthetic synthetic JJ cord-355477-7xd93aqv 178 11 peptides peptide NNS cord-355477-7xd93aqv 178 12 revealed reveal VBD cord-355477-7xd93aqv 178 13 that that IN cord-355477-7xd93aqv 178 14 amino amino NN cord-355477-7xd93aqv 178 15 acid acid NN cord-355477-7xd93aqv 178 16 residues residue NNS cord-355477-7xd93aqv 178 17 2,137,158 2,137,158 CD cord-355477-7xd93aqv 178 18 interacted interact VBD cord-355477-7xd93aqv 178 19 with with IN cord-355477-7xd93aqv 178 20 SARS SARS NNP cord-355477-7xd93aqv 178 21 patient patient NN cord-355477-7xd93aqv 178 22 sera sera NNP cord-355477-7xd93aqv 178 23 by by IN cord-355477-7xd93aqv 178 24 enzyme enzyme NN cord-355477-7xd93aqv 178 25 - - HYPH cord-355477-7xd93aqv 178 26 linked link VBN cord-355477-7xd93aqv 178 27 immunosorbent immunosorbent JJ cord-355477-7xd93aqv 178 28 assay assay NN cord-355477-7xd93aqv 178 29 , , , cord-355477-7xd93aqv 178 30 implying imply VBG cord-355477-7xd93aqv 178 31 the the DT cord-355477-7xd93aqv 178 32 potential potential JJ cord-355477-7xd93aqv 178 33 capability capability NN cord-355477-7xd93aqv 178 34 of of IN cord-355477-7xd93aqv 178 35 the the DT cord-355477-7xd93aqv 178 36 M M NNP cord-355477-7xd93aqv 178 37 protein protein NN cord-355477-7xd93aqv 178 38 to to TO cord-355477-7xd93aqv 178 39 induce induce VB cord-355477-7xd93aqv 178 40 an an DT cord-355477-7xd93aqv 178 41 immune immune JJ cord-355477-7xd93aqv 178 42 response response NN cord-355477-7xd93aqv 178 43 . . . cord-355477-7xd93aqv 179 1 The the DT cord-355477-7xd93aqv 179 2 M M NNP cord-355477-7xd93aqv 179 3 protein protein NN cord-355477-7xd93aqv 179 4 resides reside VBZ cord-355477-7xd93aqv 179 5 on on IN cord-355477-7xd93aqv 179 6 the the DT cord-355477-7xd93aqv 179 7 viral viral JJ cord-355477-7xd93aqv 179 8 envelope envelope NN cord-355477-7xd93aqv 179 9 and and CC cord-355477-7xd93aqv 179 10 in in IN cord-355477-7xd93aqv 179 11 the the DT cord-355477-7xd93aqv 179 12 internal internal JJ cord-355477-7xd93aqv 179 13 core core NN cord-355477-7xd93aqv 179 14 . . . cord-355477-7xd93aqv 180 1 In in IN cord-355477-7xd93aqv 180 2 the the DT cord-355477-7xd93aqv 180 3 cells cell NNS cord-355477-7xd93aqv 180 4 , , , cord-355477-7xd93aqv 180 5 the the DT cord-355477-7xd93aqv 180 6 M M NNP cord-355477-7xd93aqv 180 7 protein protein NN cord-355477-7xd93aqv 180 8 is be VBZ cord-355477-7xd93aqv 180 9 anchored anchor VBN cord-355477-7xd93aqv 180 10 in in IN cord-355477-7xd93aqv 180 11 the the DT cord-355477-7xd93aqv 180 12 Golgi Golgi NNP cord-355477-7xd93aqv 180 13 complex complex NN cord-355477-7xd93aqv 180 14 , , , cord-355477-7xd93aqv 180 15 thus thus RB cord-355477-7xd93aqv 180 16 dictating dictate VBG cord-355477-7xd93aqv 180 17 the the DT cord-355477-7xd93aqv 180 18 site site NN cord-355477-7xd93aqv 180 19 of of IN cord-355477-7xd93aqv 180 20 virus virus NN cord-355477-7xd93aqv 180 21 assembly assembly NN cord-355477-7xd93aqv 180 22 to to IN cord-355477-7xd93aqv 180 23 the the DT cord-355477-7xd93aqv 180 24 ER ER NNP cord-355477-7xd93aqv 180 25 - - HYPH cord-355477-7xd93aqv 180 26 Golgi Golgi NNP cord-355477-7xd93aqv 180 27 complex complex NN cord-355477-7xd93aqv 180 28 . . . cord-355477-7xd93aqv 181 1 It -PRON- PRP cord-355477-7xd93aqv 181 2 has have VBZ cord-355477-7xd93aqv 181 3 been be VBN cord-355477-7xd93aqv 181 4 shown show VBN cord-355477-7xd93aqv 181 5 that that IN cord-355477-7xd93aqv 181 6 SARS SARS NNP cord-355477-7xd93aqv 181 7 - - HYPH cord-355477-7xd93aqv 181 8 CoV CoV NNP cord-355477-7xd93aqv 181 9 M M NNP cord-355477-7xd93aqv 181 10 protein protein NN cord-355477-7xd93aqv 181 11 is be VBZ cord-355477-7xd93aqv 181 12 N n CD cord-355477-7xd93aqv 181 13 - - HYPH cord-355477-7xd93aqv 181 14 glycosylated glycosylate VBN cord-355477-7xd93aqv 181 15 at at IN cord-355477-7xd93aqv 181 16 Asn Asn NNP cord-355477-7xd93aqv 181 17 4 4 CD cord-355477-7xd93aqv 181 18 residue residue NN cord-355477-7xd93aqv 181 19 in in IN cord-355477-7xd93aqv 181 20 mammalian mammalian JJ cord-355477-7xd93aqv 181 21 cells cell NNS cord-355477-7xd93aqv 181 22 . . . cord-355477-7xd93aqv 182 1 40 40 CD cord-355477-7xd93aqv 182 2 Also also RB cord-355477-7xd93aqv 182 3 C c NN cord-355477-7xd93aqv 182 4 - - HYPH cord-355477-7xd93aqv 182 5 terminally terminally RB cord-355477-7xd93aqv 182 6 tagged tagged NNP cord-355477-7xd93aqv 182 7 M M NNP cord-355477-7xd93aqv 182 8 glycoprotein glycoprotein NN cord-355477-7xd93aqv 182 9 strongly strongly RB cord-355477-7xd93aqv 182 10 co co VBD cord-355477-7xd93aqv 182 11 - - VBZ cord-355477-7xd93aqv 182 12 localizes localize VBZ cord-355477-7xd93aqv 182 13 with with IN cord-355477-7xd93aqv 182 14 Golgi Golgi NNP cord-355477-7xd93aqv 182 15 markers marker NNS cord-355477-7xd93aqv 182 16 and and CC cord-355477-7xd93aqv 182 17 partially partially RB cord-355477-7xd93aqv 182 18 with with IN cord-355477-7xd93aqv 182 19 the the DT cord-355477-7xd93aqv 182 20 ERGIC-53 ERGIC-53 NNP cord-355477-7xd93aqv 182 21 protein protein NN cord-355477-7xd93aqv 182 22 , , , cord-355477-7xd93aqv 182 23 a a DT cord-355477-7xd93aqv 182 24 lectin lectin NN cord-355477-7xd93aqv 182 25 that that WDT cord-355477-7xd93aqv 182 26 cycles cycle NNS cord-355477-7xd93aqv 182 27 between between IN cord-355477-7xd93aqv 182 28 ER ER NNP cord-355477-7xd93aqv 182 29 , , , cord-355477-7xd93aqv 182 30 ERGIC ERGIC NNP cord-355477-7xd93aqv 182 31 , , , cord-355477-7xd93aqv 182 32 and and CC cord-355477-7xd93aqv 182 33 cis cis NNP cord-355477-7xd93aqv 182 34 - - HYPH cord-355477-7xd93aqv 182 35 Golgi Golgi NNP cord-355477-7xd93aqv 182 36 . . . cord-355477-7xd93aqv 182 37 41 41 CD cord-355477-7xd93aqv 182 38 The the DT cord-355477-7xd93aqv 182 39 envelope envelope NN cord-355477-7xd93aqv 182 40 ( ( -LRB- cord-355477-7xd93aqv 182 41 E e NN cord-355477-7xd93aqv 182 42 ) ) -RRB- cord-355477-7xd93aqv 182 43 protein protein NN cord-355477-7xd93aqv 182 44 of of IN cord-355477-7xd93aqv 182 45 the the DT cord-355477-7xd93aqv 182 46 SARS SARS NNP cord-355477-7xd93aqv 182 47 - - HYPH cord-355477-7xd93aqv 182 48 CoV CoV NNP cord-355477-7xd93aqv 182 49 is be VBZ cord-355477-7xd93aqv 182 50 , , , cord-355477-7xd93aqv 182 51 as as IN cord-355477-7xd93aqv 182 52 the the DT cord-355477-7xd93aqv 182 53 name name NN cord-355477-7xd93aqv 182 54 suggests suggest VBZ cord-355477-7xd93aqv 182 55 , , , cord-355477-7xd93aqv 182 56 the the DT cord-355477-7xd93aqv 182 57 main main JJ cord-355477-7xd93aqv 182 58 component component NN cord-355477-7xd93aqv 182 59 of of IN cord-355477-7xd93aqv 182 60 the the DT cord-355477-7xd93aqv 182 61 virus virus NN cord-355477-7xd93aqv 182 62 envelope envelope NN cord-355477-7xd93aqv 182 63 . . . cord-355477-7xd93aqv 183 1 It -PRON- PRP cord-355477-7xd93aqv 183 2 is be VBZ cord-355477-7xd93aqv 183 3 an an DT cord-355477-7xd93aqv 183 4 integral integral JJ cord-355477-7xd93aqv 183 5 membrane membrane NN cord-355477-7xd93aqv 183 6 protein protein NN cord-355477-7xd93aqv 183 7 , , , cord-355477-7xd93aqv 183 8 76 76 CD cord-355477-7xd93aqv 183 9 amino amino NN cord-355477-7xd93aqv 183 10 acids acid NNS cord-355477-7xd93aqv 183 11 long long RB cord-355477-7xd93aqv 183 12 , , , cord-355477-7xd93aqv 183 13 and and CC cord-355477-7xd93aqv 183 14 is be VBZ cord-355477-7xd93aqv 183 15 highly highly RB cord-355477-7xd93aqv 183 16 hydrophobic hydrophobic JJ cord-355477-7xd93aqv 183 17 in in IN cord-355477-7xd93aqv 183 18 nature nature NN cord-355477-7xd93aqv 183 19 . . . cord-355477-7xd93aqv 184 1 In in IN cord-355477-7xd93aqv 184 2 mammalian mammalian JJ cord-355477-7xd93aqv 184 3 cells cell NNS cord-355477-7xd93aqv 184 4 it -PRON- PRP cord-355477-7xd93aqv 184 5 is be VBZ cord-355477-7xd93aqv 184 6 found find VBN cord-355477-7xd93aqv 184 7 to to TO cord-355477-7xd93aqv 184 8 be be VB cord-355477-7xd93aqv 184 9 localized localize VBN cord-355477-7xd93aqv 184 10 to to TO cord-355477-7xd93aqv 184 11 endoplasmic endoplasmic VB cord-355477-7xd93aqv 184 12 reticulum reticulum NN cord-355477-7xd93aqv 184 13 ( ( -LRB- cord-355477-7xd93aqv 184 14 ER ER NNP cord-355477-7xd93aqv 184 15 ) ) -RRB- cord-355477-7xd93aqv 184 16 , , , cord-355477-7xd93aqv 184 17 Golgi Golgi NNP cord-355477-7xd93aqv 184 18 apparatus apparatus NN cord-355477-7xd93aqv 184 19 , , , cord-355477-7xd93aqv 184 20 and and CC cord-355477-7xd93aqv 184 21 lipid lipid NN cord-355477-7xd93aqv 184 22 rafts raft NNS cord-355477-7xd93aqv 184 23 of of IN cord-355477-7xd93aqv 184 24 cell cell NN cord-355477-7xd93aqv 184 25 membrane membrane NN cord-355477-7xd93aqv 184 26 . . . cord-355477-7xd93aqv 185 1 The the DT cord-355477-7xd93aqv 185 2 transmembrane transmembrane NN cord-355477-7xd93aqv 185 3 domain domain NN cord-355477-7xd93aqv 185 4 of of IN cord-355477-7xd93aqv 185 5 the the DT cord-355477-7xd93aqv 185 6 E e NN cord-355477-7xd93aqv 185 7 protein protein NN cord-355477-7xd93aqv 185 8 has have VBZ cord-355477-7xd93aqv 185 9 been be VBN cord-355477-7xd93aqv 185 10 found find VBN cord-355477-7xd93aqv 185 11 to to TO cord-355477-7xd93aqv 185 12 alter alter VB cord-355477-7xd93aqv 185 13 the the DT cord-355477-7xd93aqv 185 14 membrane membrane NN cord-355477-7xd93aqv 185 15 permeability permeability NN cord-355477-7xd93aqv 185 16 . . . cord-355477-7xd93aqv 186 1 42 42 CD cord-355477-7xd93aqv 186 2 ORF ORF NNP cord-355477-7xd93aqv 186 3 3a 3a NN cord-355477-7xd93aqv 186 4 is be VBZ cord-355477-7xd93aqv 186 5 also also RB cord-355477-7xd93aqv 186 6 called call VBN cord-355477-7xd93aqv 186 7 SARS SARS NNP cord-355477-7xd93aqv 186 8 X1 X1 NNP cord-355477-7xd93aqv 186 9 and and CC cord-355477-7xd93aqv 186 10 was be VBD cord-355477-7xd93aqv 186 11 initially initially RB cord-355477-7xd93aqv 186 12 named name VBN cord-355477-7xd93aqv 186 13 U274 u274 CD cord-355477-7xd93aqv 186 14 . . . cord-355477-7xd93aqv 187 1 The the DT cord-355477-7xd93aqv 187 2 3a 3a CD cord-355477-7xd93aqv 187 3 locus locus NN cord-355477-7xd93aqv 187 4 encodes encode VBZ cord-355477-7xd93aqv 187 5 an an DT cord-355477-7xd93aqv 187 6 ORF ORF NNP cord-355477-7xd93aqv 187 7 of of IN cord-355477-7xd93aqv 187 8 unknown unknown JJ cord-355477-7xd93aqv 187 9 function function NN cord-355477-7xd93aqv 187 10 and and CC cord-355477-7xd93aqv 187 11 shows show VBZ cord-355477-7xd93aqv 187 12 no no DT cord-355477-7xd93aqv 187 13 homology homology NN cord-355477-7xd93aqv 187 14 to to IN cord-355477-7xd93aqv 187 15 any any DT cord-355477-7xd93aqv 187 16 known know VBN cord-355477-7xd93aqv 187 17 protein protein NN cord-355477-7xd93aqv 187 18 . . . cord-355477-7xd93aqv 188 1 The the DT cord-355477-7xd93aqv 188 2 3a 3a NNP cord-355477-7xd93aqv 188 3 mRNA mRNA NNP cord-355477-7xd93aqv 188 4 and and CC cord-355477-7xd93aqv 188 5 3a 3a NNP cord-355477-7xd93aqv 188 6 protein protein NN cord-355477-7xd93aqv 188 7 have have VBP cord-355477-7xd93aqv 188 8 been be VBN cord-355477-7xd93aqv 188 9 detected detect VBN cord-355477-7xd93aqv 188 10 in in IN cord-355477-7xd93aqv 188 11 SARS SARS NNP cord-355477-7xd93aqv 188 12 - - HYPH cord-355477-7xd93aqv 188 13 CoVinfected CoVinfected NNP cord-355477-7xd93aqv 188 14 monkey monkey NN cord-355477-7xd93aqv 188 15 kidney kidney NN cord-355477-7xd93aqv 188 16 Vero Vero NNP cord-355477-7xd93aqv 188 17 E6 E6 NNP cord-355477-7xd93aqv 188 18 cells cell NNS cord-355477-7xd93aqv 188 19 . . . cord-355477-7xd93aqv 189 1 In in IN cord-355477-7xd93aqv 189 2 addition addition NN cord-355477-7xd93aqv 189 3 , , , cord-355477-7xd93aqv 189 4 the the DT cord-355477-7xd93aqv 189 5 3a 3a NNP cord-355477-7xd93aqv 189 6 protein protein NNP cord-355477-7xd93aqv 189 7 has have VBZ cord-355477-7xd93aqv 189 8 been be VBN cord-355477-7xd93aqv 189 9 detected detect VBN cord-355477-7xd93aqv 189 10 in in IN cord-355477-7xd93aqv 189 11 the the DT cord-355477-7xd93aqv 189 12 lung lung NN cord-355477-7xd93aqv 189 13 tissue tissue NN cord-355477-7xd93aqv 189 14 of of IN cord-355477-7xd93aqv 189 15 a a DT cord-355477-7xd93aqv 189 16 SARS SARS NNP cord-355477-7xd93aqv 189 17 patient patient NN cord-355477-7xd93aqv 189 18 . . . cord-355477-7xd93aqv 190 1 A a DT cord-355477-7xd93aqv 190 2 signal signal JJ cord-355477-7xd93aqv 190 3 sequence sequence NN cord-355477-7xd93aqv 190 4 and and CC cord-355477-7xd93aqv 190 5 three three CD cord-355477-7xd93aqv 190 6 transmembrane transmembrane NN cord-355477-7xd93aqv 190 7 domains domain NNS cord-355477-7xd93aqv 190 8 have have VBP cord-355477-7xd93aqv 190 9 been be VBN cord-355477-7xd93aqv 190 10 predicted predict VBN cord-355477-7xd93aqv 190 11 when when WRB cord-355477-7xd93aqv 190 12 3a 3a NNP cord-355477-7xd93aqv 190 13 sequence sequence NN cord-355477-7xd93aqv 190 14 was be VBD cord-355477-7xd93aqv 190 15 searched search VBN cord-355477-7xd93aqv 190 16 against against IN cord-355477-7xd93aqv 190 17 SMART smart JJ cord-355477-7xd93aqv 190 18 server server NN cord-355477-7xd93aqv 190 19 . . . cord-355477-7xd93aqv 191 1 43 43 CD cord-355477-7xd93aqv 192 1 It -PRON- PRP cord-355477-7xd93aqv 192 2 is be VBZ cord-355477-7xd93aqv 192 3 a a DT cord-355477-7xd93aqv 192 4 novel novel JJ cord-355477-7xd93aqv 192 5 SARS SARS NNP cord-355477-7xd93aqv 192 6 - - HYPH cord-355477-7xd93aqv 192 7 CoV CoV NNP cord-355477-7xd93aqv 192 8 protein protein NN cord-355477-7xd93aqv 192 9 that that WDT cord-355477-7xd93aqv 192 10 has have VBZ cord-355477-7xd93aqv 192 11 been be VBN cord-355477-7xd93aqv 192 12 shown show VBN cord-355477-7xd93aqv 192 13 to to TO cord-355477-7xd93aqv 192 14 be be VB cord-355477-7xd93aqv 192 15 transported transport VBN cord-355477-7xd93aqv 192 16 efficiently efficiently RB cord-355477-7xd93aqv 192 17 to to IN cord-355477-7xd93aqv 192 18 the the DT cord-355477-7xd93aqv 192 19 cell cell NN cord-355477-7xd93aqv 192 20 surface surface NN cord-355477-7xd93aqv 192 21 of of IN cord-355477-7xd93aqv 192 22 infected infected JJ cord-355477-7xd93aqv 192 23 and and CC cord-355477-7xd93aqv 192 24 transfected transfecte VBN cord-355477-7xd93aqv 192 25 cells cell NNS cord-355477-7xd93aqv 192 26 . . . cord-355477-7xd93aqv 193 1 Its -PRON- PRP$ cord-355477-7xd93aqv 193 2 cytoplasmic cytoplasmic JJ cord-355477-7xd93aqv 193 3 domain domain NN cord-355477-7xd93aqv 193 4 contains contain VBZ cord-355477-7xd93aqv 193 5 sorting sort VBG cord-355477-7xd93aqv 193 6 signals signal NNS cord-355477-7xd93aqv 193 7 important important JJ cord-355477-7xd93aqv 193 8 for for IN cord-355477-7xd93aqv 193 9 this this DT cord-355477-7xd93aqv 193 10 process process NN cord-355477-7xd93aqv 193 11 . . . cord-355477-7xd93aqv 194 1 The the DT cord-355477-7xd93aqv 194 2 3a 3a CD cord-355477-7xd93aqv 194 3 protein protein NN cord-355477-7xd93aqv 194 4 expressed express VBD cord-355477-7xd93aqv 194 5 on on IN cord-355477-7xd93aqv 194 6 the the DT cord-355477-7xd93aqv 194 7 cell cell NN cord-355477-7xd93aqv 194 8 surface surface NN cord-355477-7xd93aqv 194 9 can can MD cord-355477-7xd93aqv 194 10 also also RB cord-355477-7xd93aqv 194 11 undergo undergo VB cord-355477-7xd93aqv 194 12 endocytosis endocytosis NN cord-355477-7xd93aqv 194 13 . . . cord-355477-7xd93aqv 195 1 It -PRON- PRP cord-355477-7xd93aqv 195 2 has have VBZ cord-355477-7xd93aqv 195 3 been be VBN cord-355477-7xd93aqv 195 4 shown show VBN cord-355477-7xd93aqv 195 5 to to TO cord-355477-7xd93aqv 195 6 interact interact VB cord-355477-7xd93aqv 195 7 with with IN cord-355477-7xd93aqv 195 8 M M NNP cord-355477-7xd93aqv 195 9 , , , cord-355477-7xd93aqv 195 10 E E NNP cord-355477-7xd93aqv 195 11 , , , cord-355477-7xd93aqv 195 12 and and CC cord-355477-7xd93aqv 195 13 S s NN cord-355477-7xd93aqv 195 14 proteins protein NNS cord-355477-7xd93aqv 195 15 suggesting suggest VBG cord-355477-7xd93aqv 195 16 that that IN cord-355477-7xd93aqv 195 17 it -PRON- PRP cord-355477-7xd93aqv 195 18 may may MD cord-355477-7xd93aqv 195 19 play play VB cord-355477-7xd93aqv 195 20 a a DT cord-355477-7xd93aqv 195 21 role role NN cord-355477-7xd93aqv 195 22 in in IN cord-355477-7xd93aqv 195 23 viral viral JJ cord-355477-7xd93aqv 195 24 assembly assembly NN cord-355477-7xd93aqv 196 1 and/or and/or CC cord-355477-7xd93aqv 196 2 release release NN cord-355477-7xd93aqv 196 3 of of IN cord-355477-7xd93aqv 196 4 virus virus NN cord-355477-7xd93aqv 196 5 from from IN cord-355477-7xd93aqv 196 6 infected infected JJ cord-355477-7xd93aqv 196 7 cells cell NNS cord-355477-7xd93aqv 196 8 . . . cord-355477-7xd93aqv 197 1 44 44 CD cord-355477-7xd93aqv 198 1 Also also RB cord-355477-7xd93aqv 198 2 it -PRON- PRP cord-355477-7xd93aqv 198 3 has have VBZ cord-355477-7xd93aqv 198 4 been be VBN cord-355477-7xd93aqv 198 5 shown show VBN cord-355477-7xd93aqv 198 6 to to TO cord-355477-7xd93aqv 198 7 form form VB cord-355477-7xd93aqv 198 8 ion ion NN cord-355477-7xd93aqv 198 9 channels channel NNS cord-355477-7xd93aqv 198 10 in in IN cord-355477-7xd93aqv 198 11 Xenopus Xenopus NNP cord-355477-7xd93aqv 198 12 oocytes oocyte NNS cord-355477-7xd93aqv 198 13 . . . cord-355477-7xd93aqv 199 1 Formation formation NN cord-355477-7xd93aqv 199 2 of of IN cord-355477-7xd93aqv 199 3 a a DT cord-355477-7xd93aqv 199 4 pore pore NN cord-355477-7xd93aqv 199 5 in in IN cord-355477-7xd93aqv 199 6 the the DT cord-355477-7xd93aqv 199 7 infected infected JJ cord-355477-7xd93aqv 199 8 cells cell NNS cord-355477-7xd93aqv 199 9 may may MD cord-355477-7xd93aqv 199 10 aid aid VB cord-355477-7xd93aqv 199 11 in in IN cord-355477-7xd93aqv 199 12 virus virus NN cord-355477-7xd93aqv 199 13 release release NN cord-355477-7xd93aqv 199 14 . . . cord-355477-7xd93aqv 200 1 The the DT cord-355477-7xd93aqv 200 2 modulation modulation NN cord-355477-7xd93aqv 200 3 of of IN cord-355477-7xd93aqv 200 4 virus virus NN cord-355477-7xd93aqv 200 5 release release NN cord-355477-7xd93aqv 200 6 may may MD cord-355477-7xd93aqv 200 7 also also RB cord-355477-7xd93aqv 200 8 be be VB cord-355477-7xd93aqv 200 9 one one CD cord-355477-7xd93aqv 200 10 of of IN cord-355477-7xd93aqv 200 11 the the DT cord-355477-7xd93aqv 200 12 important important JJ cord-355477-7xd93aqv 200 13 functions function NNS cord-355477-7xd93aqv 200 14 of of IN cord-355477-7xd93aqv 200 15 3a 3a CD cord-355477-7xd93aqv 200 16 as as IN cord-355477-7xd93aqv 200 17 reduction reduction NN cord-355477-7xd93aqv 200 18 in in IN cord-355477-7xd93aqv 200 19 3a 3a NNP cord-355477-7xd93aqv 200 20 protein protein NN cord-355477-7xd93aqv 200 21 expression expression NN cord-355477-7xd93aqv 200 22 in in IN cord-355477-7xd93aqv 200 23 SARS SARS NNP cord-355477-7xd93aqv 200 24 - - HYPH cord-355477-7xd93aqv 200 25 infected infect VBN cord-355477-7xd93aqv 200 26 FRhK4 frhk4 CD cord-355477-7xd93aqv 200 27 cells cell NNS cord-355477-7xd93aqv 200 28 led lead VBD cord-355477-7xd93aqv 200 29 to to IN cord-355477-7xd93aqv 200 30 a a DT cord-355477-7xd93aqv 200 31 decrease decrease NN cord-355477-7xd93aqv 200 32 in in IN cord-355477-7xd93aqv 200 33 virus virus NN cord-355477-7xd93aqv 200 34 release release NN cord-355477-7xd93aqv 200 35 . . . cord-355477-7xd93aqv 201 1 48 48 CD cord-355477-7xd93aqv 201 2 3a 3a NNP cord-355477-7xd93aqv 201 3 has have VBZ cord-355477-7xd93aqv 201 4 also also RB cord-355477-7xd93aqv 201 5 been be VBN cord-355477-7xd93aqv 201 6 shown show VBN cord-355477-7xd93aqv 201 7 to to TO cord-355477-7xd93aqv 201 8 upregulate upregulate VB cord-355477-7xd93aqv 201 9 expression expression NN cord-355477-7xd93aqv 201 10 of of IN cord-355477-7xd93aqv 201 11 fibrinogen fibrinogen NN cord-355477-7xd93aqv 201 12 in in IN cord-355477-7xd93aqv 201 13 lung lung NN cord-355477-7xd93aqv 201 14 epithelial epithelial JJ cord-355477-7xd93aqv 201 15 cells cell NNS cord-355477-7xd93aqv 201 16 . . . cord-355477-7xd93aqv 202 1 mRNA mrna NN cord-355477-7xd93aqv 202 2 levels level NNS cord-355477-7xd93aqv 202 3 of of IN cord-355477-7xd93aqv 202 4 all all DT cord-355477-7xd93aqv 202 5 three three CD cord-355477-7xd93aqv 202 6 subunits subunit NNS cord-355477-7xd93aqv 202 7 of of IN cord-355477-7xd93aqv 202 8 fibrinogen fibrinogen NN cord-355477-7xd93aqv 202 9 A a NN cord-355477-7xd93aqv 202 10 ␣ ␣ NN cord-355477-7xd93aqv 202 11 , , , cord-355477-7xd93aqv 202 12 B B NNP cord-355477-7xd93aqv 202 13 ␤ ␤ NNP cord-355477-7xd93aqv 202 14 , , , cord-355477-7xd93aqv 202 15 and and CC cord-355477-7xd93aqv 202 16 ␥ ␥ NNP cord-355477-7xd93aqv 202 17 were be VBD cord-355477-7xd93aqv 202 18 found find VBN cord-355477-7xd93aqv 202 19 to to TO cord-355477-7xd93aqv 202 20 be be VB cord-355477-7xd93aqv 202 21 upregulated upregulate VBN cord-355477-7xd93aqv 202 22 . . . cord-355477-7xd93aqv 203 1 As as IN cord-355477-7xd93aqv 203 2 a a DT cord-355477-7xd93aqv 203 3 result result NN cord-355477-7xd93aqv 203 4 of of IN cord-355477-7xd93aqv 203 5 this this DT cord-355477-7xd93aqv 203 6 intracellular intracellular JJ cord-355477-7xd93aqv 203 7 levels level NNS cord-355477-7xd93aqv 203 8 as as RB cord-355477-7xd93aqv 203 9 well well RB cord-355477-7xd93aqv 203 10 as as IN cord-355477-7xd93aqv 203 11 secretion secretion NN cord-355477-7xd93aqv 203 12 of of IN cord-355477-7xd93aqv 203 13 fibrinogen fibrinogen NN cord-355477-7xd93aqv 203 14 were be VBD cord-355477-7xd93aqv 203 15 found find VBN cord-355477-7xd93aqv 203 16 to to TO cord-355477-7xd93aqv 203 17 increase increase VB cord-355477-7xd93aqv 203 18 . . . cord-355477-7xd93aqv 204 1 45 45 CD cord-355477-7xd93aqv 205 1 In in IN cord-355477-7xd93aqv 205 2 addition addition NN cord-355477-7xd93aqv 205 3 , , , cord-355477-7xd93aqv 205 4 3a 3a NNP cord-355477-7xd93aqv 205 5 protein protein NN cord-355477-7xd93aqv 205 6 has have VBZ cord-355477-7xd93aqv 205 7 also also RB cord-355477-7xd93aqv 205 8 been be VBN cord-355477-7xd93aqv 205 9 shown show VBN cord-355477-7xd93aqv 205 10 to to TO cord-355477-7xd93aqv 205 11 be be VB cord-355477-7xd93aqv 205 12 expressed express VBN cord-355477-7xd93aqv 205 13 in in IN cord-355477-7xd93aqv 205 14 the the DT cord-355477-7xd93aqv 205 15 lungs lung NNS cord-355477-7xd93aqv 205 16 and and CC cord-355477-7xd93aqv 205 17 intestinal intestinal JJ cord-355477-7xd93aqv 205 18 tissues tissue NNS cord-355477-7xd93aqv 205 19 of of IN cord-355477-7xd93aqv 205 20 SARS SARS NNP cord-355477-7xd93aqv 205 21 patients patient NNS cord-355477-7xd93aqv 205 22 and and CC cord-355477-7xd93aqv 205 23 that that IN cord-355477-7xd93aqv 205 24 the the DT cord-355477-7xd93aqv 205 25 protein protein NN cord-355477-7xd93aqv 205 26 localized localize VBN cord-355477-7xd93aqv 205 27 to to IN cord-355477-7xd93aqv 205 28 the the DT cord-355477-7xd93aqv 205 29 ER ER NNP cord-355477-7xd93aqv 205 30 in in IN cord-355477-7xd93aqv 205 31 3a 3a CD cord-355477-7xd93aqv 205 32 - - HYPH cord-355477-7xd93aqv 205 33 transfected transfecte VBN cord-355477-7xd93aqv 205 34 monkey monkey NN cord-355477-7xd93aqv 205 35 kidney kidney NN cord-355477-7xd93aqv 205 36 Vero Vero NNP cord-355477-7xd93aqv 205 37 E6 E6 NNP cord-355477-7xd93aqv 205 38 cells cell NNS cord-355477-7xd93aqv 205 39 . . . cord-355477-7xd93aqv 206 1 In in IN cord-355477-7xd93aqv 206 2 vitro vitro FW cord-355477-7xd93aqv 206 3 experiments experiment NNS cord-355477-7xd93aqv 206 4 of of IN cord-355477-7xd93aqv 206 5 chromatin chromatin NN cord-355477-7xd93aqv 206 6 condensation condensation NN cord-355477-7xd93aqv 206 7 and and CC cord-355477-7xd93aqv 206 8 DNA dna NN cord-355477-7xd93aqv 206 9 fragmentation fragmentation NN cord-355477-7xd93aqv 206 10 suggested suggest VBD cord-355477-7xd93aqv 206 11 that that IN cord-355477-7xd93aqv 206 12 the the DT cord-355477-7xd93aqv 206 13 3a 3a NNP cord-355477-7xd93aqv 206 14 protein protein NN cord-355477-7xd93aqv 206 15 may may MD cord-355477-7xd93aqv 206 16 trigger trigger VB cord-355477-7xd93aqv 206 17 apoptosis apoptosis NN cord-355477-7xd93aqv 206 18 through through IN cord-355477-7xd93aqv 206 19 a a DT cord-355477-7xd93aqv 206 20 caspase-8-dependent caspase-8-dependent JJ cord-355477-7xd93aqv 206 21 pathway pathway NN cord-355477-7xd93aqv 206 22 in in IN cord-355477-7xd93aqv 206 23 Vero Vero NNP cord-355477-7xd93aqv 206 24 E6 E6 NNP cord-355477-7xd93aqv 206 25 cells cell NNS cord-355477-7xd93aqv 206 26 . . . cord-355477-7xd93aqv 207 1 46 46 CD cord-355477-7xd93aqv 208 1 The the DT cord-355477-7xd93aqv 208 2 ORF ORF NNP cord-355477-7xd93aqv 208 3 7a 7a NN cord-355477-7xd93aqv 208 4 or or CC cord-355477-7xd93aqv 208 5 X4 X4 NNP cord-355477-7xd93aqv 208 6 Like like IN cord-355477-7xd93aqv 208 7 ORF ORF NNP cord-355477-7xd93aqv 208 8 3a 3a NN cord-355477-7xd93aqv 208 9 , , , cord-355477-7xd93aqv 208 10 sequence sequence NN cord-355477-7xd93aqv 208 11 homology homology NN cord-355477-7xd93aqv 208 12 search search NN cord-355477-7xd93aqv 208 13 yielded yield VBD cord-355477-7xd93aqv 208 14 no no DT cord-355477-7xd93aqv 208 15 significant significant JJ cord-355477-7xd93aqv 208 16 result result NN cord-355477-7xd93aqv 208 17 for for IN cord-355477-7xd93aqv 208 18 any any DT cord-355477-7xd93aqv 208 19 existing exist VBG cord-355477-7xd93aqv 208 20 proteins protein NNS cord-355477-7xd93aqv 208 21 , , , cord-355477-7xd93aqv 208 22 but but CC cord-355477-7xd93aqv 208 23 the the DT cord-355477-7xd93aqv 208 24 existence existence NN cord-355477-7xd93aqv 208 25 of of IN cord-355477-7xd93aqv 208 26 a a DT cord-355477-7xd93aqv 208 27 cleavage cleavage NN cord-355477-7xd93aqv 208 28 site site NN cord-355477-7xd93aqv 208 29 ( ( -LRB- cord-355477-7xd93aqv 208 30 between between IN cord-355477-7xd93aqv 208 31 residues residue NNS cord-355477-7xd93aqv 208 32 15 15 CD cord-355477-7xd93aqv 208 33 and and CC cord-355477-7xd93aqv 208 34 16 16 CD cord-355477-7xd93aqv 208 35 ) ) -RRB- cord-355477-7xd93aqv 208 36 and and CC cord-355477-7xd93aqv 208 37 a a DT cord-355477-7xd93aqv 208 38 transmembrane transmembrane NN cord-355477-7xd93aqv 208 39 helix helix NN cord-355477-7xd93aqv 208 40 were be VBD cord-355477-7xd93aqv 208 41 predicted predict VBN cord-355477-7xd93aqv 208 42 for for IN cord-355477-7xd93aqv 208 43 the the DT cord-355477-7xd93aqv 208 44 7a 7a NN cord-355477-7xd93aqv 208 45 protein protein NN cord-355477-7xd93aqv 208 46 . . . cord-355477-7xd93aqv 209 1 It -PRON- PRP cord-355477-7xd93aqv 209 2 has have VBZ cord-355477-7xd93aqv 209 3 recently recently RB cord-355477-7xd93aqv 209 4 been be VBN cord-355477-7xd93aqv 209 5 shown show VBN cord-355477-7xd93aqv 209 6 that that DT cord-355477-7xd93aqv 209 7 overexpression overexpression NN cord-355477-7xd93aqv 209 8 of of IN cord-355477-7xd93aqv 209 9 7a 7a NN cord-355477-7xd93aqv 209 10 induces induce VBZ cord-355477-7xd93aqv 209 11 apoptosis apoptosis NN cord-355477-7xd93aqv 209 12 via via IN cord-355477-7xd93aqv 209 13 a a DT cord-355477-7xd93aqv 209 14 caspasedependent caspasedependent NN cord-355477-7xd93aqv 209 15 pathway pathway NN cord-355477-7xd93aqv 209 16 in in IN cord-355477-7xd93aqv 209 17 different different JJ cord-355477-7xd93aqv 209 18 cell cell NN cord-355477-7xd93aqv 209 19 lines line NNS cord-355477-7xd93aqv 209 20 derived derive VBN cord-355477-7xd93aqv 209 21 from from IN cord-355477-7xd93aqv 209 22 the the DT cord-355477-7xd93aqv 209 23 lung lung NN cord-355477-7xd93aqv 209 24 , , , cord-355477-7xd93aqv 209 25 kidney kidney NN cord-355477-7xd93aqv 209 26 , , , cord-355477-7xd93aqv 209 27 and and CC cord-355477-7xd93aqv 209 28 liver liver NN cord-355477-7xd93aqv 209 29 . . . cord-355477-7xd93aqv 210 1 47 47 CD cord-355477-7xd93aqv 210 2 _SP cord-355477-7xd93aqv 210 3 Four four CD cord-355477-7xd93aqv 210 4 years year NNS cord-355477-7xd93aqv 210 5 since since IN cord-355477-7xd93aqv 210 6 the the DT cord-355477-7xd93aqv 210 7 discovery discovery NN cord-355477-7xd93aqv 210 8 of of IN cord-355477-7xd93aqv 210 9 SARS SARS NNP cord-355477-7xd93aqv 210 10 , , , cord-355477-7xd93aqv 210 11 a a DT cord-355477-7xd93aqv 210 12 great great JJ cord-355477-7xd93aqv 210 13 deal deal NN cord-355477-7xd93aqv 210 14 of of IN cord-355477-7xd93aqv 210 15 scientific scientific JJ cord-355477-7xd93aqv 210 16 coordination coordination NN cord-355477-7xd93aqv 210 17 across across IN cord-355477-7xd93aqv 210 18 the the DT cord-355477-7xd93aqv 210 19 globe globe NN cord-355477-7xd93aqv 210 20 has have VBZ cord-355477-7xd93aqv 210 21 led lead VBN cord-355477-7xd93aqv 210 22 to to IN cord-355477-7xd93aqv 210 23 unfolding unfold VBG cord-355477-7xd93aqv 210 24 of of IN cord-355477-7xd93aqv 210 25 various various JJ cord-355477-7xd93aqv 210 26 facts fact NNS cord-355477-7xd93aqv 210 27 about about IN cord-355477-7xd93aqv 210 28 this this DT cord-355477-7xd93aqv 210 29 virus virus NN cord-355477-7xd93aqv 210 30 . . . cord-355477-7xd93aqv 211 1 But but CC cord-355477-7xd93aqv 211 2 much much JJ cord-355477-7xd93aqv 211 3 needs need NNS cord-355477-7xd93aqv 211 4 to to TO cord-355477-7xd93aqv 211 5 be be VB cord-355477-7xd93aqv 211 6 learned learn VBN cord-355477-7xd93aqv 211 7 about about IN cord-355477-7xd93aqv 211 8 pathogenesis pathogenesis NN cord-355477-7xd93aqv 211 9 of of IN cord-355477-7xd93aqv 211 10 the the DT cord-355477-7xd93aqv 211 11 disease disease NN cord-355477-7xd93aqv 211 12 and and CC cord-355477-7xd93aqv 211 13 biology biology NN cord-355477-7xd93aqv 211 14 of of IN cord-355477-7xd93aqv 211 15 the the DT cord-355477-7xd93aqv 211 16 virus virus NN cord-355477-7xd93aqv 211 17 . . . cord-355477-7xd93aqv 212 1 These these DT cord-355477-7xd93aqv 212 2 aspects aspect NNS cord-355477-7xd93aqv 212 3 are be VBP cord-355477-7xd93aqv 212 4 not not RB cord-355477-7xd93aqv 212 5 fully fully RB cord-355477-7xd93aqv 212 6 understood understand VBN cord-355477-7xd93aqv 212 7 as as IN cord-355477-7xd93aqv 212 8 yet yet RB cord-355477-7xd93aqv 212 9 and and CC cord-355477-7xd93aqv 212 10 consorted consort VBN cord-355477-7xd93aqv 212 11 efforts effort NNS cord-355477-7xd93aqv 212 12 and and CC cord-355477-7xd93aqv 212 13 collaboration collaboration NN cord-355477-7xd93aqv 212 14 among among IN cord-355477-7xd93aqv 212 15 the the DT cord-355477-7xd93aqv 212 16 scientific scientific JJ cord-355477-7xd93aqv 212 17 community community NN cord-355477-7xd93aqv 212 18 are be VBP cord-355477-7xd93aqv 212 19 required require VBN cord-355477-7xd93aqv 212 20 to to TO cord-355477-7xd93aqv 212 21 unravel unravel VB cord-355477-7xd93aqv 212 22 the the DT cord-355477-7xd93aqv 212 23 mysteries mystery NNS cord-355477-7xd93aqv 212 24 surrounding surround VBG cord-355477-7xd93aqv 212 25 the the DT cord-355477-7xd93aqv 212 26 first first JJ cord-355477-7xd93aqv 212 27 pandemic pandemic NN cord-355477-7xd93aqv 212 28 of of IN cord-355477-7xd93aqv 212 29 the the DT cord-355477-7xd93aqv 212 30 21st 21st JJ cord-355477-7xd93aqv 212 31 century century NN cord-355477-7xd93aqv 212 32 . . . cord-355477-7xd93aqv 213 1 Reemergence reemergence NN cord-355477-7xd93aqv 213 2 of of IN cord-355477-7xd93aqv 213 3 SARS SARS NNP cord-355477-7xd93aqv 213 4 looms loom VBZ cord-355477-7xd93aqv 213 5 as as IN cord-355477-7xd93aqv 213 6 an an DT cord-355477-7xd93aqv 213 7 uncertain uncertain JJ cord-355477-7xd93aqv 213 8 possibility possibility NN cord-355477-7xd93aqv 213 9 . . . cord-355477-7xd93aqv 214 1 The the DT cord-355477-7xd93aqv 214 2 challenge challenge NN cord-355477-7xd93aqv 214 3 now now RB cord-355477-7xd93aqv 214 4 is be VBZ cord-355477-7xd93aqv 214 5 to to TO cord-355477-7xd93aqv 214 6 maintain maintain VB cord-355477-7xd93aqv 214 7 interest interest NN cord-355477-7xd93aqv 214 8 in in IN cord-355477-7xd93aqv 214 9 efforts effort NNS cord-355477-7xd93aqv 214 10 to to TO cord-355477-7xd93aqv 214 11 understand understand VB cord-355477-7xd93aqv 214 12 the the DT cord-355477-7xd93aqv 214 13 biology biology NN cord-355477-7xd93aqv 214 14 of of IN cord-355477-7xd93aqv 214 15 the the DT cord-355477-7xd93aqv 214 16 virus virus NN cord-355477-7xd93aqv 214 17 and and CC cord-355477-7xd93aqv 214 18 pathogenesis pathogenesis NN cord-355477-7xd93aqv 214 19 of of IN cord-355477-7xd93aqv 214 20 the the DT cord-355477-7xd93aqv 214 21 disease disease NN cord-355477-7xd93aqv 214 22 caused cause VBN cord-355477-7xd93aqv 214 23 by by IN cord-355477-7xd93aqv 214 24 it -PRON- PRP cord-355477-7xd93aqv 214 25 so so IN cord-355477-7xd93aqv 214 26 as as IN cord-355477-7xd93aqv 214 27 to to TO cord-355477-7xd93aqv 214 28 minimize minimize VB cord-355477-7xd93aqv 214 29 the the DT cord-355477-7xd93aqv 214 30 risk risk NN cord-355477-7xd93aqv 214 31 of of IN cord-355477-7xd93aqv 214 32 being be VBG cord-355477-7xd93aqv 214 33 surprised surprised JJ cord-355477-7xd93aqv 214 34 by by IN cord-355477-7xd93aqv 214 35 its -PRON- PRP$ cord-355477-7xd93aqv 214 36 sudden sudden JJ cord-355477-7xd93aqv 214 37 reappearance reappearance NN cord-355477-7xd93aqv 214 38 . . . cord-355477-7xd93aqv 215 1 The the DT cord-355477-7xd93aqv 215 2 lessons lesson NNS cord-355477-7xd93aqv 215 3 learned learn VBN cord-355477-7xd93aqv 215 4 from from IN cord-355477-7xd93aqv 215 5 SARS SARS NNP cord-355477-7xd93aqv 215 6 would would MD cord-355477-7xd93aqv 215 7 certainly certainly RB cord-355477-7xd93aqv 215 8 be be VB cord-355477-7xd93aqv 215 9 helpful helpful JJ cord-355477-7xd93aqv 215 10 to to TO cord-355477-7xd93aqv 215 11 counter counter VB cord-355477-7xd93aqv 215 12 any any DT cord-355477-7xd93aqv 215 13 reemergence reemergence NN cord-355477-7xd93aqv 215 14 of of IN cord-355477-7xd93aqv 215 15 SARS SARS NNP cord-355477-7xd93aqv 215 16 itself -PRON- PRP cord-355477-7xd93aqv 215 17 or or CC cord-355477-7xd93aqv 215 18 emergence emergence NN cord-355477-7xd93aqv 215 19 of of IN cord-355477-7xd93aqv 215 20 any any DT cord-355477-7xd93aqv 215 21 other other JJ cord-355477-7xd93aqv 215 22 pandemic pandemic NN cord-355477-7xd93aqv 215 23 . . . cord-355477-7xd93aqv 216 1 Coronavirus Coronavirus NNP cord-355477-7xd93aqv 216 2 as as IN cord-355477-7xd93aqv 216 3 a a DT cord-355477-7xd93aqv 216 4 possible possible JJ cord-355477-7xd93aqv 216 5 cause cause NN cord-355477-7xd93aqv 216 6 of of IN cord-355477-7xd93aqv 216 7 severe severe JJ cord-355477-7xd93aqv 216 8 acute acute JJ cord-355477-7xd93aqv 216 9 respiratory respiratory JJ cord-355477-7xd93aqv 216 10 syndrome syndrome NN cord-355477-7xd93aqv 216 11 Characterization characterization NN cord-355477-7xd93aqv 216 12 of of IN cord-355477-7xd93aqv 216 13 a a DT cord-355477-7xd93aqv 216 14 novel novel JJ cord-355477-7xd93aqv 216 15 coronavirus coronavirus NN cord-355477-7xd93aqv 216 16 associated associate VBN cord-355477-7xd93aqv 216 17 with with IN cord-355477-7xd93aqv 216 18 severe severe JJ cord-355477-7xd93aqv 216 19 acute acute JJ cord-355477-7xd93aqv 216 20 respiratory respiratory JJ cord-355477-7xd93aqv 216 21 syndrome syndrome NN cord-355477-7xd93aqv 217 1 The the DT cord-355477-7xd93aqv 217 2 genome genome NN cord-355477-7xd93aqv 217 3 sequence sequence NN cord-355477-7xd93aqv 217 4 of of IN cord-355477-7xd93aqv 217 5 the the DT cord-355477-7xd93aqv 217 6 SARS SARS NNP cord-355477-7xd93aqv 217 7 - - HYPH cord-355477-7xd93aqv 217 8 associated associate VBN cord-355477-7xd93aqv 217 9 coronavirus coronavirus NN cord-355477-7xd93aqv 217 10 Organ organ NN cord-355477-7xd93aqv 217 11 distribution distribution NN cord-355477-7xd93aqv 217 12 of of IN cord-355477-7xd93aqv 217 13 severe severe JJ cord-355477-7xd93aqv 217 14 acute acute JJ cord-355477-7xd93aqv 217 15 respiratory respiratory JJ cord-355477-7xd93aqv 217 16 syndrome syndrome NN cord-355477-7xd93aqv 217 17 ( ( -LRB- cord-355477-7xd93aqv 217 18 SARS SARS NNP cord-355477-7xd93aqv 217 19 ) ) -RRB- cord-355477-7xd93aqv 217 20 associated associate VBD cord-355477-7xd93aqv 217 21 coronavirus coronavirus NN cord-355477-7xd93aqv 217 22 ( ( -LRB- cord-355477-7xd93aqv 217 23 SARS SARS NNP cord-355477-7xd93aqv 217 24 - - HYPH cord-355477-7xd93aqv 217 25 CoV CoV NNP cord-355477-7xd93aqv 217 26 ) ) -RRB- cord-355477-7xd93aqv 217 27 in in IN cord-355477-7xd93aqv 217 28 SARS SARS NNP cord-355477-7xd93aqv 217 29 patients patient NNS cord-355477-7xd93aqv 217 30 : : : cord-355477-7xd93aqv 217 31 implications implication NNS cord-355477-7xd93aqv 217 32 for for IN cord-355477-7xd93aqv 217 33 pathogenesis pathogenesis NN cord-355477-7xd93aqv 217 34 and and CC cord-355477-7xd93aqv 217 35 virus virus NN cord-355477-7xd93aqv 217 36 transmission transmission NN cord-355477-7xd93aqv 217 37 pathways pathway NNS cord-355477-7xd93aqv 218 1 Fatal fatal JJ cord-355477-7xd93aqv 218 2 severe severe JJ cord-355477-7xd93aqv 218 3 acute acute JJ cord-355477-7xd93aqv 218 4 respiratory respiratory JJ cord-355477-7xd93aqv 218 5 syndrome syndrome NN cord-355477-7xd93aqv 218 6 is be VBZ cord-355477-7xd93aqv 218 7 associated associate VBN cord-355477-7xd93aqv 218 8 with with IN cord-355477-7xd93aqv 218 9 multiorgan multiorgan NN cord-355477-7xd93aqv 218 10 involvement involvement NN cord-355477-7xd93aqv 218 11 by by IN cord-355477-7xd93aqv 218 12 coronavirus coronavirus NN cord-355477-7xd93aqv 218 13 pH ph NN cord-355477-7xd93aqv 218 14 - - HYPH cord-355477-7xd93aqv 218 15 dependent dependent JJ cord-355477-7xd93aqv 218 16 entry entry NN cord-355477-7xd93aqv 218 17 of of IN cord-355477-7xd93aqv 218 18 severe severe JJ cord-355477-7xd93aqv 218 19 acute acute JJ cord-355477-7xd93aqv 218 20 respiratory respiratory JJ cord-355477-7xd93aqv 218 21 syndrome syndrome NN cord-355477-7xd93aqv 218 22 coronavirus coronavirus NN cord-355477-7xd93aqv 218 23 is be VBZ cord-355477-7xd93aqv 218 24 mediated mediate VBN cord-355477-7xd93aqv 218 25 by by IN cord-355477-7xd93aqv 218 26 the the DT cord-355477-7xd93aqv 218 27 spike spike NN cord-355477-7xd93aqv 218 28 glycoprotein glycoprotein NN cord-355477-7xd93aqv 218 29 and and CC cord-355477-7xd93aqv 218 30 enhanced enhance VBN cord-355477-7xd93aqv 218 31 by by IN cord-355477-7xd93aqv 218 32 dendritic dendritic JJ cord-355477-7xd93aqv 218 33 cell cell NN cord-355477-7xd93aqv 218 34 transfer transfer NN cord-355477-7xd93aqv 218 35 through through IN cord-355477-7xd93aqv 218 36 DC DC NNP cord-355477-7xd93aqv 218 37 - - HYPH cord-355477-7xd93aqv 218 38 SIGN SIGN NNP cord-355477-7xd93aqv 218 39 Tissue tissue NN cord-355477-7xd93aqv 218 40 distribution distribution NN cord-355477-7xd93aqv 218 41 of of IN cord-355477-7xd93aqv 218 42 ACE2 ACE2 NNP cord-355477-7xd93aqv 218 43 protein protein NN cord-355477-7xd93aqv 218 44 , , , cord-355477-7xd93aqv 218 45 the the DT cord-355477-7xd93aqv 218 46 functional functional JJ cord-355477-7xd93aqv 218 47 receptor receptor NN cord-355477-7xd93aqv 218 48 for for IN cord-355477-7xd93aqv 218 49 SARS SARS NNP cord-355477-7xd93aqv 218 50 coronavirus coronavirus NN cord-355477-7xd93aqv 218 51 . . . cord-355477-7xd93aqv 219 1 A a DT cord-355477-7xd93aqv 219 2 first first JJ cord-355477-7xd93aqv 219 3 step step NN cord-355477-7xd93aqv 219 4 in in IN cord-355477-7xd93aqv 219 5 understanding understand VBG cord-355477-7xd93aqv 219 6 SARS SARS NNP cord-355477-7xd93aqv 219 7 pathogenesis pathogenesis NN cord-355477-7xd93aqv 219 8 Mechanisms mechanism NNS cord-355477-7xd93aqv 219 9 and and CC cord-355477-7xd93aqv 219 10 enzymes enzyme NNS cord-355477-7xd93aqv 219 11 involved involve VBN cord-355477-7xd93aqv 219 12 in in IN cord-355477-7xd93aqv 219 13 SARS SARS NNP cord-355477-7xd93aqv 219 14 coronavirus coronavirus NN cord-355477-7xd93aqv 219 15 genome genome NN cord-355477-7xd93aqv 219 16 expression expression NN cord-355477-7xd93aqv 219 17 Molecular molecular JJ cord-355477-7xd93aqv 219 18 biology biology NN cord-355477-7xd93aqv 219 19 of of IN cord-355477-7xd93aqv 219 20 severe severe JJ cord-355477-7xd93aqv 219 21 acute acute JJ cord-355477-7xd93aqv 219 22 respiratory respiratory JJ cord-355477-7xd93aqv 219 23 syndrome syndrome NN cord-355477-7xd93aqv 219 24 coronavirus coronavirus NN cord-355477-7xd93aqv 220 1 A a DT cord-355477-7xd93aqv 220 2 193 193 CD cord-355477-7xd93aqv 220 3 amino amino NN cord-355477-7xd93aqv 220 4 acid acid NN cord-355477-7xd93aqv 220 5 fragment fragment NN cord-355477-7xd93aqv 220 6 of of IN cord-355477-7xd93aqv 220 7 SARS SARS NNP cord-355477-7xd93aqv 220 8 coronavirus coronavirus NN cord-355477-7xd93aqv 220 9 S S NNP cord-355477-7xd93aqv 220 10 protein protein NN cord-355477-7xd93aqv 220 11 efficiently efficiently RB cord-355477-7xd93aqv 220 12 binds bind VBZ cord-355477-7xd93aqv 220 13 angiotensin angiotensin NN cord-355477-7xd93aqv 220 14 converting convert VBG cord-355477-7xd93aqv 220 15 enzyme enzyme NN cord-355477-7xd93aqv 220 16 2 2 CD cord-355477-7xd93aqv 220 17 Mass Mass NNP cord-355477-7xd93aqv 220 18 spectrometric spectrometric JJ cord-355477-7xd93aqv 220 19 characterization characterization NN cord-355477-7xd93aqv 220 20 of of IN cord-355477-7xd93aqv 220 21 proteins protein NNS cord-355477-7xd93aqv 220 22 from from IN cord-355477-7xd93aqv 220 23 the the DT cord-355477-7xd93aqv 220 24 SARS SARS NNP cord-355477-7xd93aqv 220 25 virus virus NN cord-355477-7xd93aqv 220 26 : : : cord-355477-7xd93aqv 220 27 a a DT cord-355477-7xd93aqv 220 28 preliminary preliminary JJ cord-355477-7xd93aqv 220 29 report report NN cord-355477-7xd93aqv 220 30 Proteomic Proteomic NNP cord-355477-7xd93aqv 220 31 analysis analysis NN cord-355477-7xd93aqv 220 32 on on IN cord-355477-7xd93aqv 220 33 structural structural JJ cord-355477-7xd93aqv 220 34 proteins protein NNS cord-355477-7xd93aqv 220 35 of of IN cord-355477-7xd93aqv 220 36 severe severe JJ cord-355477-7xd93aqv 220 37 acute acute JJ cord-355477-7xd93aqv 220 38 respiratory respiratory JJ cord-355477-7xd93aqv 220 39 syndrome syndrome NN cord-355477-7xd93aqv 220 40 coronavirus coronavirus NN cord-355477-7xd93aqv 220 41 Differential differential JJ cord-355477-7xd93aqv 220 42 maturation maturation NN cord-355477-7xd93aqv 220 43 and and CC cord-355477-7xd93aqv 220 44 subcellular subcellular JJ cord-355477-7xd93aqv 220 45 localization localization NN cord-355477-7xd93aqv 220 46 of of IN cord-355477-7xd93aqv 220 47 severe severe JJ cord-355477-7xd93aqv 220 48 acute acute JJ cord-355477-7xd93aqv 220 49 respiratory respiratory JJ cord-355477-7xd93aqv 220 50 syndrome syndrome NN cord-355477-7xd93aqv 220 51 coronavirus coronavirus NN cord-355477-7xd93aqv 220 52 surface surface NN cord-355477-7xd93aqv 220 53 proteins protein NNS cord-355477-7xd93aqv 220 54 S S NNP cord-355477-7xd93aqv 220 55 , , , cord-355477-7xd93aqv 220 56 M M NNP cord-355477-7xd93aqv 220 57 and and CC cord-355477-7xd93aqv 220 58 E E NNP cord-355477-7xd93aqv 220 59 Structure Structure NNP cord-355477-7xd93aqv 220 60 of of IN cord-355477-7xd93aqv 220 61 SARS SARS NNP cord-355477-7xd93aqv 220 62 coronavirus coronavirus NN cord-355477-7xd93aqv 220 63 spike spike NN cord-355477-7xd93aqv 220 64 receptor receptor NN cord-355477-7xd93aqv 220 65 - - HYPH cord-355477-7xd93aqv 220 66 binding bind VBG cord-355477-7xd93aqv 220 67 domain domain NN cord-355477-7xd93aqv 220 68 complexed complexe VBN cord-355477-7xd93aqv 220 69 with with IN cord-355477-7xd93aqv 220 70 receptor receptor NN cord-355477-7xd93aqv 220 71 Profile Profile NNP cord-355477-7xd93aqv 220 72 of of IN cord-355477-7xd93aqv 220 73 antibodies antibody NNS cord-355477-7xd93aqv 220 74 to to IN cord-355477-7xd93aqv 220 75 the the DT cord-355477-7xd93aqv 220 76 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 220 77 protein protein NN cord-355477-7xd93aqv 220 78 of of IN cord-355477-7xd93aqv 220 79 the the DT cord-355477-7xd93aqv 220 80 severe severe JJ cord-355477-7xd93aqv 220 81 acute acute JJ cord-355477-7xd93aqv 220 82 respiratory respiratory JJ cord-355477-7xd93aqv 220 83 syndrome syndrome NN cord-355477-7xd93aqv 220 84 ( ( -LRB- cord-355477-7xd93aqv 220 85 SARS)-associated sars)-associated CD cord-355477-7xd93aqv 220 86 coronavirus coronavirus NN cord-355477-7xd93aqv 220 87 in in IN cord-355477-7xd93aqv 220 88 probable probable JJ cord-355477-7xd93aqv 220 89 SARS SARS NNP cord-355477-7xd93aqv 220 90 patients patient NNS cord-355477-7xd93aqv 220 91 Diagnosis Diagnosis NNP cord-355477-7xd93aqv 220 92 of of IN cord-355477-7xd93aqv 220 93 severe severe JJ cord-355477-7xd93aqv 220 94 acute acute JJ cord-355477-7xd93aqv 220 95 respiratory respiratory JJ cord-355477-7xd93aqv 220 96 syndrome syndrome NN cord-355477-7xd93aqv 220 97 ( ( -LRB- cord-355477-7xd93aqv 220 98 SARS SARS NNP cord-355477-7xd93aqv 220 99 ) ) -RRB- cord-355477-7xd93aqv 220 100 by by IN cord-355477-7xd93aqv 220 101 detection detection NN cord-355477-7xd93aqv 220 102 of of IN cord-355477-7xd93aqv 220 103 SARS SARS NNP cord-355477-7xd93aqv 220 104 coronavirus coronavirus NN cord-355477-7xd93aqv 220 105 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 220 106 antibodies antibody NNS cord-355477-7xd93aqv 220 107 in in IN cord-355477-7xd93aqv 220 108 an an DT cord-355477-7xd93aqv 220 109 antigencapturing antigencapture VBG cord-355477-7xd93aqv 220 110 enzyme enzyme NN cord-355477-7xd93aqv 220 111 - - HYPH cord-355477-7xd93aqv 220 112 linked link VBN cord-355477-7xd93aqv 220 113 immunosorbent immunosorbent JJ cord-355477-7xd93aqv 220 114 assay assay NN cord-355477-7xd93aqv 220 115 Assessment Assessment NNP cord-355477-7xd93aqv 220 116 of of IN cord-355477-7xd93aqv 220 117 immunoreactive immunoreactive JJ cord-355477-7xd93aqv 220 118 synthetic synthetic JJ cord-355477-7xd93aqv 220 119 peptides peptide NNS cord-355477-7xd93aqv 220 120 from from IN cord-355477-7xd93aqv 220 121 the the DT cord-355477-7xd93aqv 220 122 structural structural JJ cord-355477-7xd93aqv 220 123 proteins protein NNS cord-355477-7xd93aqv 220 124 of of IN cord-355477-7xd93aqv 220 125 severe severe JJ cord-355477-7xd93aqv 220 126 acute acute JJ cord-355477-7xd93aqv 220 127 respiratory respiratory JJ cord-355477-7xd93aqv 220 128 syndrome syndrome NN cord-355477-7xd93aqv 220 129 coronavirus coronavirus NN cord-355477-7xd93aqv 220 130 Mapping mapping NN cord-355477-7xd93aqv 220 131 of of IN cord-355477-7xd93aqv 220 132 antigenic antigenic JJ cord-355477-7xd93aqv 220 133 sites site NNS cord-355477-7xd93aqv 220 134 on on IN cord-355477-7xd93aqv 220 135 the the DT cord-355477-7xd93aqv 220 136 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 220 137 protein protein NN cord-355477-7xd93aqv 220 138 of of IN cord-355477-7xd93aqv 220 139 the the DT cord-355477-7xd93aqv 220 140 severe severe JJ cord-355477-7xd93aqv 220 141 acute acute JJ cord-355477-7xd93aqv 220 142 respiratory respiratory JJ cord-355477-7xd93aqv 220 143 syndrome syndrome NN cord-355477-7xd93aqv 220 144 coronavirus coronavirus NN cord-355477-7xd93aqv 220 145 Antigenic antigenic JJ cord-355477-7xd93aqv 220 146 structure structure NN cord-355477-7xd93aqv 220 147 of of IN cord-355477-7xd93aqv 220 148 transmissible transmissible JJ cord-355477-7xd93aqv 220 149 gastroenteritis gastroenteritis NN cord-355477-7xd93aqv 220 150 virus virus NN cord-355477-7xd93aqv 220 151 nucleoprotein nucleoprotein NNP cord-355477-7xd93aqv 220 152 Location Location NNP cord-355477-7xd93aqv 220 153 of of IN cord-355477-7xd93aqv 220 154 antibody antibody NN cord-355477-7xd93aqv 220 155 epitopes epitope NNS cord-355477-7xd93aqv 220 156 within within IN cord-355477-7xd93aqv 220 157 the the DT cord-355477-7xd93aqv 220 158 mouse mouse NN cord-355477-7xd93aqv 220 159 hepatitis hepatitis NNP cord-355477-7xd93aqv 220 160 virus virus NN cord-355477-7xd93aqv 220 161 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 220 162 protein protein NN cord-355477-7xd93aqv 220 163 Localization Localization NNP cord-355477-7xd93aqv 220 164 of of IN cord-355477-7xd93aqv 220 165 linear linear JJ cord-355477-7xd93aqv 220 166 B b NN cord-355477-7xd93aqv 220 167 - - HYPH cord-355477-7xd93aqv 220 168 cell cell NN cord-355477-7xd93aqv 220 169 epitopes epitope NNS cord-355477-7xd93aqv 220 170 on on IN cord-355477-7xd93aqv 220 171 infectious infectious JJ cord-355477-7xd93aqv 220 172 bronchitis bronchitis NN cord-355477-7xd93aqv 220 173 virus virus NN cord-355477-7xd93aqv 220 174 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 220 175 protein protein NNP cord-355477-7xd93aqv 221 1 The the DT cord-355477-7xd93aqv 221 2 epitope epitope NN cord-355477-7xd93aqv 221 3 study study NN cord-355477-7xd93aqv 221 4 on on IN cord-355477-7xd93aqv 221 5 the the DT cord-355477-7xd93aqv 221 6 SARS SARS NNP cord-355477-7xd93aqv 221 7 - - HYPH cord-355477-7xd93aqv 221 8 CoV CoV NNP cord-355477-7xd93aqv 221 9 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 221 10 protein protein NNP cord-355477-7xd93aqv 221 11 Structure Structure NNP cord-355477-7xd93aqv 221 12 of of IN cord-355477-7xd93aqv 221 13 the the DT cord-355477-7xd93aqv 221 14 N n CD cord-355477-7xd93aqv 221 15 - - HYPH cord-355477-7xd93aqv 221 16 terminal terminal JJ cord-355477-7xd93aqv 221 17 RNAbinding rnabinding NN cord-355477-7xd93aqv 221 18 domain domain NN cord-355477-7xd93aqv 221 19 of of IN cord-355477-7xd93aqv 221 20 the the DT cord-355477-7xd93aqv 221 21 SARS SARS NNP cord-355477-7xd93aqv 221 22 CoV CoV NNP cord-355477-7xd93aqv 221 23 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 221 24 protein protein NNP cord-355477-7xd93aqv 221 25 Assembly Assembly NNP cord-355477-7xd93aqv 221 26 of of IN cord-355477-7xd93aqv 221 27 severe severe JJ cord-355477-7xd93aqv 221 28 acute acute JJ cord-355477-7xd93aqv 221 29 respiratory respiratory JJ cord-355477-7xd93aqv 221 30 syndrome syndrome NN cord-355477-7xd93aqv 221 31 coronavirus coronavirus NN cord-355477-7xd93aqv 221 32 RNA RNA NNP cord-355477-7xd93aqv 221 33 packaging packaging NN cord-355477-7xd93aqv 221 34 signal signal NN cord-355477-7xd93aqv 221 35 into into IN cord-355477-7xd93aqv 221 36 virus virus NN cord-355477-7xd93aqv 221 37 - - HYPH cord-355477-7xd93aqv 221 38 like like JJ cord-355477-7xd93aqv 221 39 particles particle NNS cord-355477-7xd93aqv 221 40 is be VBZ cord-355477-7xd93aqv 221 41 nucleocapsid nucleocapsid RB cord-355477-7xd93aqv 221 42 dependent dependent JJ cord-355477-7xd93aqv 222 1 The the DT cord-355477-7xd93aqv 222 2 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 222 3 protein protein NN cord-355477-7xd93aqv 222 4 of of IN cord-355477-7xd93aqv 222 5 the the DT cord-355477-7xd93aqv 222 6 SARS SARS NNP cord-355477-7xd93aqv 222 7 coronavirus coronavirus NN cord-355477-7xd93aqv 222 8 is be VBZ cord-355477-7xd93aqv 222 9 capable capable JJ cord-355477-7xd93aqv 222 10 of of IN cord-355477-7xd93aqv 222 11 self self NN cord-355477-7xd93aqv 222 12 - - HYPH cord-355477-7xd93aqv 222 13 association association NN cord-355477-7xd93aqv 222 14 through through IN cord-355477-7xd93aqv 222 15 a a DT cord-355477-7xd93aqv 222 16 C C NNP cord-355477-7xd93aqv 222 17 - - HYPH cord-355477-7xd93aqv 222 18 terminal terminal NN cord-355477-7xd93aqv 222 19 209 209 CD cord-355477-7xd93aqv 222 20 amino amino NN cord-355477-7xd93aqv 222 21 acid acid NN cord-355477-7xd93aqv 222 22 interaction interaction NN cord-355477-7xd93aqv 222 23 domain domain NN cord-355477-7xd93aqv 222 24 Recombinant recombinant JJ cord-355477-7xd93aqv 222 25 severe severe JJ cord-355477-7xd93aqv 222 26 acute acute JJ cord-355477-7xd93aqv 222 27 respiratory respiratory JJ cord-355477-7xd93aqv 222 28 syndrome syndrome NN cord-355477-7xd93aqv 222 29 ( ( -LRB- cord-355477-7xd93aqv 222 30 SARS SARS NNP cord-355477-7xd93aqv 222 31 ) ) -RRB- cord-355477-7xd93aqv 223 1 coronavirus coronavirus NNP cord-355477-7xd93aqv 223 2 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 223 3 protein protein NNP cord-355477-7xd93aqv 223 4 forms form VBZ cord-355477-7xd93aqv 223 5 a a DT cord-355477-7xd93aqv 223 6 dimer dimer NN cord-355477-7xd93aqv 223 7 through through IN cord-355477-7xd93aqv 223 8 its -PRON- PRP$ cord-355477-7xd93aqv 223 9 C c NN cord-355477-7xd93aqv 223 10 - - HYPH cord-355477-7xd93aqv 223 11 terminal terminal NN cord-355477-7xd93aqv 223 12 domain domain NN cord-355477-7xd93aqv 224 1 Nucleocapsid nucleocapsid JJ cord-355477-7xd93aqv 224 2 protein protein NN cord-355477-7xd93aqv 224 3 of of IN cord-355477-7xd93aqv 224 4 SARS SARS NNP cord-355477-7xd93aqv 224 5 coronavirus coronavirus NN cord-355477-7xd93aqv 224 6 tightly tightly RB cord-355477-7xd93aqv 224 7 binds bind VBZ cord-355477-7xd93aqv 224 8 to to IN cord-355477-7xd93aqv 224 9 human human JJ cord-355477-7xd93aqv 224 10 cyclophilin cyclophilin NN cord-355477-7xd93aqv 225 1 A a DT cord-355477-7xd93aqv 225 2 Crystal Crystal NNP cord-355477-7xd93aqv 225 3 structure structure NN cord-355477-7xd93aqv 225 4 of of IN cord-355477-7xd93aqv 225 5 human human JJ cord-355477-7xd93aqv 225 6 cyclophilin cyclophilin NNP cord-355477-7xd93aqv 225 7 A A NNP cord-355477-7xd93aqv 225 8 bound bind VBN cord-355477-7xd93aqv 225 9 to to IN cord-355477-7xd93aqv 225 10 the the DT cord-355477-7xd93aqv 225 11 amino amino NN cord-355477-7xd93aqv 225 12 - - HYPH cord-355477-7xd93aqv 225 13 terminal terminal NN cord-355477-7xd93aqv 225 14 domain domain NN cord-355477-7xd93aqv 225 15 of of IN cord-355477-7xd93aqv 225 16 HIV-1 HIV-1 NNP cord-355477-7xd93aqv 225 17 capsid capsid NN cord-355477-7xd93aqv 226 1 The the DT cord-355477-7xd93aqv 226 2 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 226 3 protein protein NN cord-355477-7xd93aqv 226 4 of of IN cord-355477-7xd93aqv 226 5 SARS SARS NNP cord-355477-7xd93aqv 226 6 coronavirus coronavirus NN cord-355477-7xd93aqv 226 7 has have VBZ cord-355477-7xd93aqv 226 8 a a DT cord-355477-7xd93aqv 226 9 high high JJ cord-355477-7xd93aqv 226 10 binding bind VBG cord-355477-7xd93aqv 226 11 affinity affinity NN cord-355477-7xd93aqv 226 12 to to IN cord-355477-7xd93aqv 226 13 the the DT cord-355477-7xd93aqv 226 14 human human JJ cord-355477-7xd93aqv 226 15 cellular cellular JJ cord-355477-7xd93aqv 226 16 heterogeneous heterogeneous JJ cord-355477-7xd93aqv 226 17 nuclear nuclear JJ cord-355477-7xd93aqv 226 18 ribonucleoprotein ribonucleoprotein NN cord-355477-7xd93aqv 226 19 A1 A1 NNP cord-355477-7xd93aqv 226 20 Crystal Crystal NNP cord-355477-7xd93aqv 226 21 structure structure NN cord-355477-7xd93aqv 226 22 of of IN cord-355477-7xd93aqv 226 23 human human JJ cord-355477-7xd93aqv 226 24 UP1 UP1 NNP cord-355477-7xd93aqv 226 25 , , , cord-355477-7xd93aqv 226 26 the the DT cord-355477-7xd93aqv 226 27 domain domain NN cord-355477-7xd93aqv 226 28 of of IN cord-355477-7xd93aqv 226 29 hnRNP hnrnp DT cord-355477-7xd93aqv 227 1 A1that a1that DT cord-355477-7xd93aqv 227 2 contains contain VBZ cord-355477-7xd93aqv 227 3 two two CD cord-355477-7xd93aqv 227 4 RNA RNA NNP cord-355477-7xd93aqv 227 5 - - HYPH cord-355477-7xd93aqv 227 6 recognition recognition NN cord-355477-7xd93aqv 227 7 motifs motif NNS cord-355477-7xd93aqv 228 1 The the DT cord-355477-7xd93aqv 228 2 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 228 3 protein protein NN cord-355477-7xd93aqv 228 4 of of IN cord-355477-7xd93aqv 228 5 coronavirus coronavirus NNP cord-355477-7xd93aqv 228 6 mouse mouse NN cord-355477-7xd93aqv 228 7 hepatitis hepatitis NN cord-355477-7xd93aqv 228 8 virus virus NN cord-355477-7xd93aqv 228 9 interacts interact VBZ cord-355477-7xd93aqv 228 10 with with IN cord-355477-7xd93aqv 228 11 the the DT cord-355477-7xd93aqv 228 12 cellular cellular JJ cord-355477-7xd93aqv 228 13 heterogeneous heterogeneous JJ cord-355477-7xd93aqv 228 14 nuclear nuclear JJ cord-355477-7xd93aqv 228 15 ribonucleoprotein ribonucleoprotein NN cord-355477-7xd93aqv 228 16 A1 A1 NNP cord-355477-7xd93aqv 228 17 in in IN cord-355477-7xd93aqv 228 18 vitro vitro FW cord-355477-7xd93aqv 228 19 and and CC cord-355477-7xd93aqv 228 20 in in IN cord-355477-7xd93aqv 228 21 vivo vivo NNP cord-355477-7xd93aqv 228 22 Activation Activation NNP cord-355477-7xd93aqv 228 23 of of IN cord-355477-7xd93aqv 228 24 AP-1 AP-1 NNP cord-355477-7xd93aqv 228 25 signal signal NN cord-355477-7xd93aqv 228 26 transduction transduction NN cord-355477-7xd93aqv 228 27 pathway pathway NN cord-355477-7xd93aqv 228 28 by by IN cord-355477-7xd93aqv 228 29 SARS SARS NNP cord-355477-7xd93aqv 228 30 coronavirus coronavirus NN cord-355477-7xd93aqv 228 31 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 228 32 protein protein NN cord-355477-7xd93aqv 229 1 The the DT cord-355477-7xd93aqv 229 2 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 229 3 protein protein NN cord-355477-7xd93aqv 229 4 of of IN cord-355477-7xd93aqv 229 5 sars sars NNP cord-355477-7xd93aqv 229 6 - - HYPH cord-355477-7xd93aqv 229 7 coronavirus coronavirus NN cord-355477-7xd93aqv 229 8 inhibits inhibit VBZ cord-355477-7xd93aqv 229 9 the the DT cord-355477-7xd93aqv 229 10 activity activity NN cord-355477-7xd93aqv 229 11 of of IN cord-355477-7xd93aqv 229 12 cyclin cyclin JJ cord-355477-7xd93aqv 229 13 - - HYPH cord-355477-7xd93aqv 229 14 CDK CDK NNP cord-355477-7xd93aqv 229 15 complex complex NN cord-355477-7xd93aqv 229 16 and and CC cord-355477-7xd93aqv 229 17 blocks block VBZ cord-355477-7xd93aqv 229 18 S s NN cord-355477-7xd93aqv 229 19 phase phase NN cord-355477-7xd93aqv 229 20 progression progression NN cord-355477-7xd93aqv 229 21 in in IN cord-355477-7xd93aqv 229 22 mammalian mammalian JJ cord-355477-7xd93aqv 229 23 cells cell NNS cord-355477-7xd93aqv 230 1 The the DT cord-355477-7xd93aqv 230 2 SARS SARS NNP cord-355477-7xd93aqv 230 3 coronavirus coronavirus NN cord-355477-7xd93aqv 230 4 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 230 5 protein protein NN cord-355477-7xd93aqv 230 6 induces induce VBZ cord-355477-7xd93aqv 230 7 actin actin NN cord-355477-7xd93aqv 230 8 reorganization reorganization NN cord-355477-7xd93aqv 230 9 and and CC cord-355477-7xd93aqv 230 10 apoptosis apoptosis NN cord-355477-7xd93aqv 230 11 in in IN cord-355477-7xd93aqv 230 12 COS-1 COS-1 NNP cord-355477-7xd93aqv 230 13 cells cell NNS cord-355477-7xd93aqv 230 14 in in IN cord-355477-7xd93aqv 230 15 the the DT cord-355477-7xd93aqv 230 16 absence absence NN cord-355477-7xd93aqv 230 17 of of IN cord-355477-7xd93aqv 230 18 growth growth NN cord-355477-7xd93aqv 230 19 factors factor NNS cord-355477-7xd93aqv 230 20 Nuclear nuclear JJ cord-355477-7xd93aqv 230 21 / / SYM cord-355477-7xd93aqv 230 22 nucleolar nucleolar JJ cord-355477-7xd93aqv 230 23 localization localization NN cord-355477-7xd93aqv 230 24 properties property NNS cord-355477-7xd93aqv 230 25 of of IN cord-355477-7xd93aqv 230 26 C C NNP cord-355477-7xd93aqv 230 27 - - HYPH cord-355477-7xd93aqv 230 28 terminal terminal NNP cord-355477-7xd93aqv 230 29 nucleocapsid nucleocapsid NNP cord-355477-7xd93aqv 230 30 protein protein NN cord-355477-7xd93aqv 230 31 of of IN cord-355477-7xd93aqv 230 32 SARS SARS NNP cord-355477-7xd93aqv 230 33 coronavirus coronavirus NN cord-355477-7xd93aqv 231 1 The the DT cord-355477-7xd93aqv 231 2 severe severe JJ cord-355477-7xd93aqv 231 3 acute acute JJ cord-355477-7xd93aqv 231 4 respiratory respiratory JJ cord-355477-7xd93aqv 231 5 syndrome syndrome NN cord-355477-7xd93aqv 231 6 coronavirus coronavirus NN cord-355477-7xd93aqv 231 7 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 231 8 protein protein NN cord-355477-7xd93aqv 231 9 is be VBZ cord-355477-7xd93aqv 231 10 phosphorylated phosphorylate VBN cord-355477-7xd93aqv 231 11 and and CC cord-355477-7xd93aqv 231 12 localizes localize VBZ cord-355477-7xd93aqv 231 13 in in IN cord-355477-7xd93aqv 231 14 the the DT cord-355477-7xd93aqv 231 15 cytoplasm cytoplasm NN cord-355477-7xd93aqv 231 16 by by IN cord-355477-7xd93aqv 231 17 14 14 CD cord-355477-7xd93aqv 231 18 - - SYM cord-355477-7xd93aqv 231 19 3 3 CD cord-355477-7xd93aqv 231 20 - - HYPH cord-355477-7xd93aqv 231 21 3-mediated 3-mediated CD cord-355477-7xd93aqv 231 22 translocation translocation NN cord-355477-7xd93aqv 231 23 Phosphorylation Phosphorylation NNP cord-355477-7xd93aqv 231 24 of of IN cord-355477-7xd93aqv 231 25 the the DT cord-355477-7xd93aqv 231 26 porcine porcine JJ cord-355477-7xd93aqv 231 27 reproductive reproductive JJ cord-355477-7xd93aqv 231 28 and and CC cord-355477-7xd93aqv 231 29 respiratory respiratory JJ cord-355477-7xd93aqv 231 30 syndrome syndrome NN cord-355477-7xd93aqv 231 31 virus virus NN cord-355477-7xd93aqv 231 32 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 231 33 protein protein NN cord-355477-7xd93aqv 231 34 Intracellular Intracellular NNP cord-355477-7xd93aqv 231 35 localization localization NN cord-355477-7xd93aqv 231 36 of of IN cord-355477-7xd93aqv 231 37 the the DT cord-355477-7xd93aqv 231 38 severe severe JJ cord-355477-7xd93aqv 231 39 acute acute JJ cord-355477-7xd93aqv 231 40 respiratory respiratory JJ cord-355477-7xd93aqv 231 41 syndrome syndrome NN cord-355477-7xd93aqv 231 42 coronavirus coronavirus NN cord-355477-7xd93aqv 231 43 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 231 44 protein protein NN cord-355477-7xd93aqv 231 45 : : : cord-355477-7xd93aqv 231 46 absence absence NN cord-355477-7xd93aqv 231 47 of of IN cord-355477-7xd93aqv 231 48 nucleolar nucleolar JJ cord-355477-7xd93aqv 231 49 accumulation accumulation NN cord-355477-7xd93aqv 231 50 during during IN cord-355477-7xd93aqv 231 51 infection infection NN cord-355477-7xd93aqv 231 52 and and CC cord-355477-7xd93aqv 231 53 after after IN cord-355477-7xd93aqv 231 54 expression expression NN cord-355477-7xd93aqv 231 55 as as IN cord-355477-7xd93aqv 231 56 a a DT cord-355477-7xd93aqv 231 57 recombinant recombinant JJ cord-355477-7xd93aqv 231 58 protein protein NN cord-355477-7xd93aqv 231 59 in in IN cord-355477-7xd93aqv 231 60 vero vero NNP cord-355477-7xd93aqv 231 61 cells cell NNS cord-355477-7xd93aqv 231 62 Peptide Peptide NNP cord-355477-7xd93aqv 231 63 domain domain NN cord-355477-7xd93aqv 231 64 involved involve VBN cord-355477-7xd93aqv 231 65 in in IN cord-355477-7xd93aqv 231 66 the the DT cord-355477-7xd93aqv 231 67 interaction interaction NN cord-355477-7xd93aqv 231 68 between between IN cord-355477-7xd93aqv 231 69 membrane membrane NN cord-355477-7xd93aqv 231 70 protein protein NN cord-355477-7xd93aqv 231 71 and and CC cord-355477-7xd93aqv 231 72 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 231 73 protein protein NN cord-355477-7xd93aqv 231 74 of of IN cord-355477-7xd93aqv 231 75 SARS SARS NNP cord-355477-7xd93aqv 231 76 - - HYPH cord-355477-7xd93aqv 231 77 associated associate VBN cord-355477-7xd93aqv 231 78 coronavirus coronavirus NN cord-355477-7xd93aqv 231 79 Characterization characterization NN cord-355477-7xd93aqv 231 80 of of IN cord-355477-7xd93aqv 231 81 severe severe JJ cord-355477-7xd93aqv 231 82 acute acute JJ cord-355477-7xd93aqv 231 83 respiratory respiratory JJ cord-355477-7xd93aqv 231 84 syndrome syndrome NN cord-355477-7xd93aqv 231 85 coronavirus coronavirus NN cord-355477-7xd93aqv 231 86 membrane membrane NN cord-355477-7xd93aqv 231 87 protein protein NN cord-355477-7xd93aqv 231 88 Differential differential JJ cord-355477-7xd93aqv 231 89 maturation maturation NN cord-355477-7xd93aqv 231 90 and and CC cord-355477-7xd93aqv 231 91 subcellular subcellular JJ cord-355477-7xd93aqv 231 92 localization localization NN cord-355477-7xd93aqv 231 93 of of IN cord-355477-7xd93aqv 231 94 severe severe JJ cord-355477-7xd93aqv 231 95 acute acute JJ cord-355477-7xd93aqv 231 96 respiratory respiratory JJ cord-355477-7xd93aqv 231 97 syndrome syndrome NN cord-355477-7xd93aqv 231 98 coronavirus coronavirus NN cord-355477-7xd93aqv 231 99 surface surface NN cord-355477-7xd93aqv 231 100 proteins protein NNS cord-355477-7xd93aqv 231 101 S S NNP cord-355477-7xd93aqv 231 102 , , , cord-355477-7xd93aqv 231 103 M M NNP cord-355477-7xd93aqv 231 104 and and CC cord-355477-7xd93aqv 231 105 E E NNP cord-355477-7xd93aqv 231 106 Biochemical biochemical JJ cord-355477-7xd93aqv 231 107 and and CC cord-355477-7xd93aqv 231 108 functional functional JJ cord-355477-7xd93aqv 231 109 characterization characterization NN cord-355477-7xd93aqv 231 110 of of IN cord-355477-7xd93aqv 231 111 the the DT cord-355477-7xd93aqv 231 112 membrane membrane NN cord-355477-7xd93aqv 231 113 association association NNP cord-355477-7xd93aqv 231 114 and and CC cord-355477-7xd93aqv 231 115 membrane membrane NN cord-355477-7xd93aqv 231 116 permeabilizing permeabilizing NN cord-355477-7xd93aqv 231 117 activity activity NN cord-355477-7xd93aqv 231 118 of of IN cord-355477-7xd93aqv 231 119 the the DT cord-355477-7xd93aqv 231 120 severe severe JJ cord-355477-7xd93aqv 231 121 acute acute JJ cord-355477-7xd93aqv 231 122 respiratory respiratory JJ cord-355477-7xd93aqv 231 123 syndrome syndrome NN cord-355477-7xd93aqv 231 124 coronavirus coronavirus NN cord-355477-7xd93aqv 231 125 envelope envelope NN cord-355477-7xd93aqv 231 126 protein protein NN cord-355477-7xd93aqv 232 1 The the DT cord-355477-7xd93aqv 232 2 3a 3a CD cord-355477-7xd93aqv 232 3 protein protein NN cord-355477-7xd93aqv 232 4 of of IN cord-355477-7xd93aqv 232 5 severe severe JJ cord-355477-7xd93aqv 232 6 acute acute JJ cord-355477-7xd93aqv 232 7 respiratory respiratory JJ cord-355477-7xd93aqv 232 8 syndrome syndrome NN cord-355477-7xd93aqv 232 9 - - HYPH cord-355477-7xd93aqv 232 10 associated associate VBN cord-355477-7xd93aqv 232 11 coronavirus coronavirus NN cord-355477-7xd93aqv 232 12 induces induce VBZ cord-355477-7xd93aqv 232 13 apoptosis apoptosis NN cord-355477-7xd93aqv 232 14 in in IN cord-355477-7xd93aqv 232 15 Vero Vero NNP cord-355477-7xd93aqv 232 16 E6 E6 NNP cord-355477-7xd93aqv 232 17 cells cell NNS cord-355477-7xd93aqv 233 1 The the DT cord-355477-7xd93aqv 233 2 severe severe JJ cord-355477-7xd93aqv 233 3 acute acute JJ cord-355477-7xd93aqv 233 4 respiratory respiratory JJ cord-355477-7xd93aqv 233 5 syndrome syndrome NN cord-355477-7xd93aqv 233 6 ( ( -LRB- cord-355477-7xd93aqv 233 7 SARS SARS NNP cord-355477-7xd93aqv 233 8 ) ) -RRB- cord-355477-7xd93aqv 233 9 coronavirus coronavirus NN cord-355477-7xd93aqv 234 1 3a 3a NNP cord-355477-7xd93aqv 234 2 protein protein NNP cord-355477-7xd93aqv 234 3 may may MD cord-355477-7xd93aqv 234 4 function function VB cord-355477-7xd93aqv 234 5 as as IN cord-355477-7xd93aqv 234 6 a a DT cord-355477-7xd93aqv 234 7 modulator modulator NN cord-355477-7xd93aqv 234 8 of of IN cord-355477-7xd93aqv 234 9 the the DT cord-355477-7xd93aqv 234 10 trafficking trafficking NN cord-355477-7xd93aqv 234 11 properties property NNS cord-355477-7xd93aqv 234 12 of of IN cord-355477-7xd93aqv 234 13 the the DT cord-355477-7xd93aqv 234 14 spike spike NN cord-355477-7xd93aqv 234 15 protein protein NN cord-355477-7xd93aqv 235 1 The the DT cord-355477-7xd93aqv 235 2 severe severe JJ cord-355477-7xd93aqv 235 3 acute acute JJ cord-355477-7xd93aqv 235 4 respiratory respiratory JJ cord-355477-7xd93aqv 235 5 syndrome syndrome NN cord-355477-7xd93aqv 235 6 coronavirus coronavirus NN cord-355477-7xd93aqv 235 7 3a 3a CD cord-355477-7xd93aqv 235 8 protein protein NN cord-355477-7xd93aqv 235 9 up up RB cord-355477-7xd93aqv 235 10 - - HYPH cord-355477-7xd93aqv 235 11 regulates regulate VBZ cord-355477-7xd93aqv 235 12 expression expression NN cord-355477-7xd93aqv 235 13 of of IN cord-355477-7xd93aqv 235 14 fibrinogen fibrinogen NN cord-355477-7xd93aqv 235 15 in in IN cord-355477-7xd93aqv 235 16 lung lung NN cord-355477-7xd93aqv 235 17 epithelial epithelial NN cord-355477-7xd93aqv 235 18 cells cell NNS cord-355477-7xd93aqv 236 1 The the DT cord-355477-7xd93aqv 236 2 3a 3a CD cord-355477-7xd93aqv 236 3 protein protein NN cord-355477-7xd93aqv 236 4 of of IN cord-355477-7xd93aqv 236 5 severe severe JJ cord-355477-7xd93aqv 236 6 acute acute JJ cord-355477-7xd93aqv 236 7 respiratory respiratory JJ cord-355477-7xd93aqv 236 8 syndrome syndrome NN cord-355477-7xd93aqv 236 9 - - HYPH cord-355477-7xd93aqv 236 10 associated associate VBN cord-355477-7xd93aqv 236 11 coronavirus coronavirus NN cord-355477-7xd93aqv 236 12 induces induce VBZ cord-355477-7xd93aqv 236 13 apoptosis apoptosis NN cord-355477-7xd93aqv 236 14 in in IN cord-355477-7xd93aqv 236 15 Vero Vero NNP cord-355477-7xd93aqv 236 16 E6 E6 NNP cord-355477-7xd93aqv 236 17 cells cell NNS cord-355477-7xd93aqv 236 18 Overexpression Overexpression NNP cord-355477-7xd93aqv 236 19 of of IN cord-355477-7xd93aqv 236 20 7a 7a NN cord-355477-7xd93aqv 236 21 , , , cord-355477-7xd93aqv 237 1 a a DT cord-355477-7xd93aqv 237 2 protein protein NN cord-355477-7xd93aqv 237 3 specifically specifically RB cord-355477-7xd93aqv 237 4 encoded encode VBN cord-355477-7xd93aqv 237 5 by by IN cord-355477-7xd93aqv 237 6 severe severe JJ cord-355477-7xd93aqv 237 7 acute acute JJ cord-355477-7xd93aqv 237 8 respiratory respiratory JJ cord-355477-7xd93aqv 237 9 syndrome syndrome NN cord-355477-7xd93aqv 237 10 coronavirus coronavirus NN cord-355477-7xd93aqv 237 11 , , , cord-355477-7xd93aqv 237 12 induces induce VBZ cord-355477-7xd93aqv 237 13 apoptosis apoptosis NN cord-355477-7xd93aqv 237 14 via via IN cord-355477-7xd93aqv 237 15 a a DT cord-355477-7xd93aqv 237 16 caspase caspase NN cord-355477-7xd93aqv 237 17 - - HYPH cord-355477-7xd93aqv 237 18 dependent dependent JJ cord-355477-7xd93aqv 237 19 pathway pathway NN cord-355477-7xd93aqv 237 20 Severe severe JJ cord-355477-7xd93aqv 237 21 acute acute JJ cord-355477-7xd93aqv 237 22 respiratory respiratory JJ cord-355477-7xd93aqv 237 23 syndromeassociated syndromeassociate VBN cord-355477-7xd93aqv 237 24 coronavirus coronavirus NN cord-355477-7xd93aqv 237 25 3a 3a NNP cord-355477-7xd93aqv 237 26 protein protein NNP cord-355477-7xd93aqv 237 27 forms form VBZ cord-355477-7xd93aqv 237 28 an an DT cord-355477-7xd93aqv 237 29 ion ion NN cord-355477-7xd93aqv 237 30 channel channel NN cord-355477-7xd93aqv 237 31 and and CC cord-355477-7xd93aqv 237 32 modulates modulate VBZ cord-355477-7xd93aqv 237 33 virus virus NN cord-355477-7xd93aqv 237 34 release release NN cord-355477-7xd93aqv 237 35 Carboxyl Carboxyl NNP cord-355477-7xd93aqv 237 36 terminus terminus NN cord-355477-7xd93aqv 237 37 of of IN cord-355477-7xd93aqv 237 38 severe severe JJ cord-355477-7xd93aqv 237 39 acute acute JJ cord-355477-7xd93aqv 237 40 respiratory respiratory JJ cord-355477-7xd93aqv 237 41 coronavirus coronavirus NN cord-355477-7xd93aqv 237 42 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 237 43 protein protein NN cord-355477-7xd93aqv 237 44 : : : cord-355477-7xd93aqv 237 45 self self NN cord-355477-7xd93aqv 237 46 - - HYPH cord-355477-7xd93aqv 237 47 association association NN cord-355477-7xd93aqv 237 48 analysis analysis NN cord-355477-7xd93aqv 237 49 and and CC cord-355477-7xd93aqv 237 50 nucleic nucleic JJ cord-355477-7xd93aqv 237 51 acid acid NN cord-355477-7xd93aqv 237 52 binding bind VBG cord-355477-7xd93aqv 237 53 characteristics characteristic NNS cord-355477-7xd93aqv 238 1 Nucleocapsid nucleocapsid JJ cord-355477-7xd93aqv 238 2 amino amino JJ cord-355477-7xd93aqv 238 3 acids acid NNS cord-355477-7xd93aqv 238 4 211 211 CD cord-355477-7xd93aqv 238 5 to to IN cord-355477-7xd93aqv 238 6 254 254 CD cord-355477-7xd93aqv 238 7 , , , cord-355477-7xd93aqv 238 8 in in IN cord-355477-7xd93aqv 238 9 particular particular JJ cord-355477-7xd93aqv 238 10 , , , cord-355477-7xd93aqv 238 11 tetrad tetrad NNP cord-355477-7xd93aqv 238 12 glutamines glutamines NNP cord-355477-7xd93aqv 238 13 , , , cord-355477-7xd93aqv 238 14 are be VBP cord-355477-7xd93aqv 238 15 essential essential JJ cord-355477-7xd93aqv 238 16 for for IN cord-355477-7xd93aqv 238 17 the the DT cord-355477-7xd93aqv 238 18 interaction interaction NN cord-355477-7xd93aqv 238 19 between between IN cord-355477-7xd93aqv 238 20 the the DT cord-355477-7xd93aqv 238 21 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 238 22 and and CC cord-355477-7xd93aqv 238 23 membrane membrane NN cord-355477-7xd93aqv 238 24 proteins protein NNS cord-355477-7xd93aqv 238 25 of of IN cord-355477-7xd93aqv 238 26 SARS SARS NNP cord-355477-7xd93aqv 238 27 - - HYPH cord-355477-7xd93aqv 238 28 associated associate VBN cord-355477-7xd93aqv 238 29 coronavirus coronavirus NN cord-355477-7xd93aqv 238 30 Coronavirus Coronavirus NNP cord-355477-7xd93aqv 238 31 nucleocapsid nucleocapsid NN cord-355477-7xd93aqv 238 32 protein protein NN cord-355477-7xd93aqv 238 33 is be VBZ cord-355477-7xd93aqv 238 34 an an DT cord-355477-7xd93aqv 238 35 RNA RNA NNP cord-355477-7xd93aqv 238 36 chaperone chaperone NN