id sid tid token lemma pos cord-299560-np6nfvf2 1 1 key key NN cord-299560-np6nfvf2 1 2 : : : cord-299560-np6nfvf2 2 1 cord-299560-np6nfvf2 cord-299560-np6nfvf2 NNP cord-299560-np6nfvf2 2 2 authors author NNS cord-299560-np6nfvf2 2 3 : : : cord-299560-np6nfvf2 2 4 Hendaus Hendaus NNP cord-299560-np6nfvf2 2 5 , , , cord-299560-np6nfvf2 2 6 Mohamed Mohamed NNP cord-299560-np6nfvf2 2 7 A. a. NN cord-299560-np6nfvf2 2 8 title title NN cord-299560-np6nfvf2 2 9 : : : cord-299560-np6nfvf2 2 10 Remdesivir Remdesivir NNP cord-299560-np6nfvf2 2 11 in in IN cord-299560-np6nfvf2 2 12 the the DT cord-299560-np6nfvf2 2 13 treatment treatment NN cord-299560-np6nfvf2 2 14 of of IN cord-299560-np6nfvf2 2 15 coronavirus coronavirus NN cord-299560-np6nfvf2 2 16 disease disease NN cord-299560-np6nfvf2 2 17 2019 2019 CD cord-299560-np6nfvf2 2 18 ( ( -LRB- cord-299560-np6nfvf2 2 19 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 2 20 ) ) -RRB- cord-299560-np6nfvf2 2 21 : : : cord-299560-np6nfvf2 2 22 a a DT cord-299560-np6nfvf2 2 23 simplified simplified JJ cord-299560-np6nfvf2 2 24 summary summary NN cord-299560-np6nfvf2 2 25 date date NN cord-299560-np6nfvf2 2 26 : : : cord-299560-np6nfvf2 2 27 2020 2020 CD cord-299560-np6nfvf2 2 28 - - HYPH cord-299560-np6nfvf2 2 29 05 05 CD cord-299560-np6nfvf2 2 30 - - HYPH cord-299560-np6nfvf2 2 31 20 20 CD cord-299560-np6nfvf2 2 32 journal journal NN cord-299560-np6nfvf2 2 33 : : : cord-299560-np6nfvf2 2 34 J J NNP cord-299560-np6nfvf2 2 35 Biomol Biomol NNP cord-299560-np6nfvf2 2 36 Struct Struct NNP cord-299560-np6nfvf2 2 37 Dyn Dyn NNP cord-299560-np6nfvf2 2 38 DOI doi NN cord-299560-np6nfvf2 2 39 : : : cord-299560-np6nfvf2 2 40 10.1080/07391102.2020.1767691 10.1080/07391102.2020.1767691 NN cord-299560-np6nfvf2 2 41 sha sha NN cord-299560-np6nfvf2 2 42 : : : cord-299560-np6nfvf2 2 43 5b4c58a72735267d2c9e1da133c35c8d885a917b 5b4c58a72735267d2c9e1da133c35c8d885a917b CD cord-299560-np6nfvf2 2 44 doc_id doc_id CD cord-299560-np6nfvf2 2 45 : : : cord-299560-np6nfvf2 2 46 299560 299560 CD cord-299560-np6nfvf2 2 47 cord_uid cord_uid NNS cord-299560-np6nfvf2 2 48 : : : cord-299560-np6nfvf2 3 1 np6nfvf2 np6nfvf2 NNP cord-299560-np6nfvf2 4 1 The the DT cord-299560-np6nfvf2 4 2 pandemic pandemic NN cord-299560-np6nfvf2 4 3 of of IN cord-299560-np6nfvf2 4 4 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 4 5 ( ( -LRB- cord-299560-np6nfvf2 4 6 Coronavirus Coronavirus NNP cord-299560-np6nfvf2 4 7 Disease-2019 Disease-2019 NNP cord-299560-np6nfvf2 4 8 ) ) -RRB- cord-299560-np6nfvf2 4 9 is be VBZ cord-299560-np6nfvf2 4 10 an an DT cord-299560-np6nfvf2 4 11 extremely extremely RB cord-299560-np6nfvf2 4 12 contagious contagious JJ cord-299560-np6nfvf2 4 13 respiratory respiratory JJ cord-299560-np6nfvf2 4 14 illness illness NN cord-299560-np6nfvf2 4 15 due due IN cord-299560-np6nfvf2 4 16 to to IN cord-299560-np6nfvf2 4 17 a a DT cord-299560-np6nfvf2 4 18 novel novel JJ cord-299560-np6nfvf2 4 19 coronavirus coronavirus NN cord-299560-np6nfvf2 4 20 , , , cord-299560-np6nfvf2 4 21 SARS SARS NNP cord-299560-np6nfvf2 4 22 - - HYPH cord-299560-np6nfvf2 4 23 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 4 24 . . . cord-299560-np6nfvf2 5 1 Certain certain JJ cord-299560-np6nfvf2 5 2 drugs drug NNS cord-299560-np6nfvf2 5 3 have have VBP cord-299560-np6nfvf2 5 4 several several JJ cord-299560-np6nfvf2 5 5 protein protein NN cord-299560-np6nfvf2 5 6 targets target NNS cord-299560-np6nfvf2 5 7 and and CC cord-299560-np6nfvf2 5 8 many many JJ cord-299560-np6nfvf2 5 9 illnesses illness NNS cord-299560-np6nfvf2 5 10 share share VBP cord-299560-np6nfvf2 5 11 overlapping overlap VBG cord-299560-np6nfvf2 5 12 molecular molecular JJ cord-299560-np6nfvf2 5 13 paths path NNS cord-299560-np6nfvf2 5 14 . . . cord-299560-np6nfvf2 6 1 In in IN cord-299560-np6nfvf2 6 2 such such JJ cord-299560-np6nfvf2 6 3 cases case NNS cord-299560-np6nfvf2 6 4 , , , cord-299560-np6nfvf2 6 5 reusing reuse VBG cord-299560-np6nfvf2 6 6 drugs drug NNS cord-299560-np6nfvf2 6 7 for for IN cord-299560-np6nfvf2 6 8 more more JJR cord-299560-np6nfvf2 6 9 than than IN cord-299560-np6nfvf2 6 10 one one CD cord-299560-np6nfvf2 6 11 objective objective NN cord-299560-np6nfvf2 6 12 and and CC cord-299560-np6nfvf2 6 13 finding find VBG cord-299560-np6nfvf2 6 14 their -PRON- PRP$ cord-299560-np6nfvf2 6 15 novice novice NN cord-299560-np6nfvf2 6 16 uses use NNS cord-299560-np6nfvf2 6 17 can can MD cord-299560-np6nfvf2 6 18 considerably considerably RB cord-299560-np6nfvf2 6 19 decrease decrease VB cord-299560-np6nfvf2 6 20 the the DT cord-299560-np6nfvf2 6 21 time time NN cord-299560-np6nfvf2 6 22 in in IN cord-299560-np6nfvf2 6 23 finding find VBG cord-299560-np6nfvf2 6 24 new new JJ cord-299560-np6nfvf2 6 25 cures cure NNS cord-299560-np6nfvf2 6 26 for for IN cord-299560-np6nfvf2 6 27 unforeseen unforeseen JJ cord-299560-np6nfvf2 6 28 diseases disease NNS cord-299560-np6nfvf2 6 29 . . . cord-299560-np6nfvf2 7 1 Remdesivir Remdesivir NNP cord-299560-np6nfvf2 7 2 has have VBZ cord-299560-np6nfvf2 7 3 been be VBN cord-299560-np6nfvf2 7 4 recently recently RB cord-299560-np6nfvf2 7 5 a a DT cord-299560-np6nfvf2 7 6 strong strong JJ cord-299560-np6nfvf2 7 7 candidate candidate NN cord-299560-np6nfvf2 7 8 for for IN cord-299560-np6nfvf2 7 9 the the DT cord-299560-np6nfvf2 7 10 treatment treatment NN cord-299560-np6nfvf2 7 11 of of IN cord-299560-np6nfvf2 7 12 Covid-19 covid-19 NN cord-299560-np6nfvf2 7 13 . . . cord-299560-np6nfvf2 8 1 In in IN cord-299560-np6nfvf2 8 2 this this DT cord-299560-np6nfvf2 8 3 commentary commentary NN cord-299560-np6nfvf2 8 4 , , , cord-299560-np6nfvf2 8 5 we -PRON- PRP cord-299560-np6nfvf2 8 6 have have VBP cord-299560-np6nfvf2 8 7 portrayed portray VBN cord-299560-np6nfvf2 8 8 the the DT cord-299560-np6nfvf2 8 9 structure structure NN cord-299560-np6nfvf2 8 10 of of IN cord-299560-np6nfvf2 8 11 the the DT cord-299560-np6nfvf2 8 12 coronavirus coronavirus NN cord-299560-np6nfvf2 8 13 in in IN cord-299560-np6nfvf2 8 14 a a DT cord-299560-np6nfvf2 8 15 simple simple JJ cord-299560-np6nfvf2 8 16 way way NN cord-299560-np6nfvf2 8 17 as as RB cord-299560-np6nfvf2 8 18 well well RB cord-299560-np6nfvf2 8 19 as as IN cord-299560-np6nfvf2 8 20 the the DT cord-299560-np6nfvf2 8 21 site site NN cord-299560-np6nfvf2 8 22 where where WRB cord-299560-np6nfvf2 8 23 remdesivir remdesivir NNP cord-299560-np6nfvf2 8 24 acts act VBZ cord-299560-np6nfvf2 8 25 . . . cord-299560-np6nfvf2 9 1 We -PRON- PRP cord-299560-np6nfvf2 9 2 have have VBP cord-299560-np6nfvf2 9 3 also also RB cord-299560-np6nfvf2 9 4 displayed display VBN cord-299560-np6nfvf2 9 5 the the DT cord-299560-np6nfvf2 9 6 ongoing ongoing JJ cord-299560-np6nfvf2 9 7 clinical clinical JJ cord-299560-np6nfvf2 9 8 trials trial NNS cord-299560-np6nfvf2 9 9 , , , cord-299560-np6nfvf2 9 10 as as RB cord-299560-np6nfvf2 9 11 well well RB cord-299560-np6nfvf2 9 12 as as IN cord-299560-np6nfvf2 9 13 a a DT cord-299560-np6nfvf2 9 14 published publish VBN cord-299560-np6nfvf2 9 15 study study NN cord-299560-np6nfvf2 9 16 that that WDT cord-299560-np6nfvf2 9 17 was be VBD cord-299560-np6nfvf2 9 18 conducted conduct VBN cord-299560-np6nfvf2 9 19 on on IN cord-299560-np6nfvf2 9 20 compassionate compassionate JJ cord-299560-np6nfvf2 9 21 base base NN cord-299560-np6nfvf2 9 22 . . . cord-299560-np6nfvf2 10 1 The the DT cord-299560-np6nfvf2 10 2 covid-19 covid-19 CD cord-299560-np6nfvf2 10 3 pandemic pandemic NN cord-299560-np6nfvf2 10 4 might may MD cord-299560-np6nfvf2 10 5 wean wean VB cord-299560-np6nfvf2 10 6 down down RP cord-299560-np6nfvf2 10 7 by by IN cord-299560-np6nfvf2 10 8 the the DT cord-299560-np6nfvf2 10 9 end end NN cord-299560-np6nfvf2 10 10 of of IN cord-299560-np6nfvf2 10 11 summer summer NN cord-299560-np6nfvf2 10 12 2020 2020 CD cord-299560-np6nfvf2 10 13 , , , cord-299560-np6nfvf2 10 14 but but CC cord-299560-np6nfvf2 10 15 the the DT cord-299560-np6nfvf2 10 16 risk risk NN cord-299560-np6nfvf2 10 17 of of IN cord-299560-np6nfvf2 10 18 seasonality seasonality NN cord-299560-np6nfvf2 10 19 exists exist VBZ cord-299560-np6nfvf2 10 20 . . . cord-299560-np6nfvf2 11 1 Therefore therefore RB cord-299560-np6nfvf2 11 2 , , , cord-299560-np6nfvf2 11 3 future future JJ cord-299560-np6nfvf2 11 4 disposal disposal NN cord-299560-np6nfvf2 11 5 of of IN cord-299560-np6nfvf2 11 6 agents agent NNS cord-299560-np6nfvf2 11 7 such such JJ cord-299560-np6nfvf2 11 8 as as IN cord-299560-np6nfvf2 11 9 remdesivir remdesivir NNP cord-299560-np6nfvf2 11 10 might may MD cord-299560-np6nfvf2 11 11 be be VB cord-299560-np6nfvf2 11 12 crucial crucial JJ cord-299560-np6nfvf2 11 13 for for IN cord-299560-np6nfvf2 11 14 ensuring ensure VBG cord-299560-np6nfvf2 11 15 an an DT cord-299560-np6nfvf2 11 16 efficient efficient JJ cord-299560-np6nfvf2 11 17 treatment treatment NN cord-299560-np6nfvf2 11 18 , , , cord-299560-np6nfvf2 11 19 decrease decrease VB cord-299560-np6nfvf2 11 20 mortality mortality NN cord-299560-np6nfvf2 11 21 and and CC cord-299560-np6nfvf2 11 22 allow allow VB cord-299560-np6nfvf2 11 23 early early JJ cord-299560-np6nfvf2 11 24 discharge discharge NN cord-299560-np6nfvf2 11 25 . . . cord-299560-np6nfvf2 12 1 Communicated communicate VBN cord-299560-np6nfvf2 12 2 by by IN cord-299560-np6nfvf2 12 3 Ramaswamy Ramaswamy NNP cord-299560-np6nfvf2 12 4 H. H. NNP cord-299560-np6nfvf2 12 5 Sarma Sarma NNP cord-299560-np6nfvf2 13 1 The the DT cord-299560-np6nfvf2 13 2 pandemic pandemic NN cord-299560-np6nfvf2 13 3 of of IN cord-299560-np6nfvf2 13 4 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 13 5 ( ( -LRB- cord-299560-np6nfvf2 13 6 Coronavirus Coronavirus NNP cord-299560-np6nfvf2 13 7 Disease-2019 Disease-2019 NNP cord-299560-np6nfvf2 13 8 ) ) -RRB- cord-299560-np6nfvf2 13 9 is be VBZ cord-299560-np6nfvf2 13 10 an an DT cord-299560-np6nfvf2 13 11 extremely extremely RB cord-299560-np6nfvf2 13 12 contagious contagious JJ cord-299560-np6nfvf2 13 13 respiratory respiratory JJ cord-299560-np6nfvf2 13 14 illness illness NN cord-299560-np6nfvf2 14 1 ( ( -LRB- cord-299560-np6nfvf2 14 2 Elmezayen Elmezayen NNP cord-299560-np6nfvf2 14 3 et et FW cord-299560-np6nfvf2 14 4 al al NNP cord-299560-np6nfvf2 14 5 . . . cord-299560-np6nfvf2 15 1 , , , cord-299560-np6nfvf2 15 2 2020 2020 CD cord-299560-np6nfvf2 15 3 ; ; : cord-299560-np6nfvf2 15 4 Sarma Sarma NNP cord-299560-np6nfvf2 15 5 et et NNP cord-299560-np6nfvf2 15 6 al al NNP cord-299560-np6nfvf2 15 7 . . NNP cord-299560-np6nfvf2 15 8 , , , cord-299560-np6nfvf2 15 9 2020 2020 CD cord-299560-np6nfvf2 15 10 ) ) -RRB- cord-299560-np6nfvf2 15 11 . . . cord-299560-np6nfvf2 16 1 Globally globally RB cord-299560-np6nfvf2 16 2 , , , cord-299560-np6nfvf2 16 3 scientists scientist NNS cord-299560-np6nfvf2 16 4 are be VBP cord-299560-np6nfvf2 16 5 attempting attempt VBG cord-299560-np6nfvf2 16 6 to to TO cord-299560-np6nfvf2 16 7 study study VB cord-299560-np6nfvf2 16 8 this this DT cord-299560-np6nfvf2 16 9 novel novel JJ cord-299560-np6nfvf2 16 10 virus virus NN cord-299560-np6nfvf2 16 11 , , , cord-299560-np6nfvf2 16 12 and and CC cord-299560-np6nfvf2 16 13 to to TO cord-299560-np6nfvf2 16 14 discover discover VB cord-299560-np6nfvf2 16 15 efficient efficient JJ cord-299560-np6nfvf2 16 16 management management NN cord-299560-np6nfvf2 16 17 to to TO cord-299560-np6nfvf2 16 18 control control VB cord-299560-np6nfvf2 16 19 and and CC cord-299560-np6nfvf2 16 20 prevent prevent VB cord-299560-np6nfvf2 16 21 the the DT cord-299560-np6nfvf2 16 22 illness illness NN cord-299560-np6nfvf2 17 1 ( ( -LRB- cord-299560-np6nfvf2 17 2 Enayatkhani Enayatkhani NNP cord-299560-np6nfvf2 17 3 et et NNP cord-299560-np6nfvf2 17 4 al al NNP cord-299560-np6nfvf2 17 5 . . NNP cord-299560-np6nfvf2 17 6 , , , cord-299560-np6nfvf2 17 7 2020 2020 CD cord-299560-np6nfvf2 17 8 ) ) -RRB- cord-299560-np6nfvf2 17 9 . . . cord-299560-np6nfvf2 18 1 The the DT cord-299560-np6nfvf2 18 2 common common JJ cord-299560-np6nfvf2 18 3 symptoms symptom NNS cord-299560-np6nfvf2 18 4 of of IN cord-299560-np6nfvf2 18 5 Covid-19 covid-19 JJ cord-299560-np6nfvf2 18 6 symptoms symptom NNS cord-299560-np6nfvf2 18 7 are be VBP cord-299560-np6nfvf2 18 8 malaise malaise NN cord-299560-np6nfvf2 18 9 , , , cord-299560-np6nfvf2 18 10 fever fever NN cord-299560-np6nfvf2 18 11 , , , cord-299560-np6nfvf2 18 12 shortness shortness NN cord-299560-np6nfvf2 18 13 of of IN cord-299560-np6nfvf2 18 14 breath breath NN cord-299560-np6nfvf2 18 15 , , , cord-299560-np6nfvf2 18 16 dry dry JJ cord-299560-np6nfvf2 18 17 cough cough NN cord-299560-np6nfvf2 18 18 , , , cord-299560-np6nfvf2 18 19 malaise malaise NN cord-299560-np6nfvf2 18 20 , , , cord-299560-np6nfvf2 18 21 while while IN cord-299560-np6nfvf2 18 22 decreased decrease VBD cord-299560-np6nfvf2 18 23 or or CC cord-299560-np6nfvf2 18 24 loss loss NN cord-299560-np6nfvf2 18 25 of of IN cord-299560-np6nfvf2 18 26 taste taste NN cord-299560-np6nfvf2 18 27 and and CC cord-299560-np6nfvf2 18 28 olfactory olfactory JJ cord-299560-np6nfvf2 18 29 perceptions perception NNS cord-299560-np6nfvf2 18 30 have have VBP cord-299560-np6nfvf2 18 31 been be VBN cord-299560-np6nfvf2 18 32 reported report VBN cord-299560-np6nfvf2 18 33 ( ( -LRB- cord-299560-np6nfvf2 18 34 Elfiky Elfiky NNP cord-299560-np6nfvf2 18 35 , , , cord-299560-np6nfvf2 18 36 2020a 2020a CD cord-299560-np6nfvf2 18 37 ) ) -RRB- cord-299560-np6nfvf2 18 38 . . . cord-299560-np6nfvf2 19 1 The the DT cord-299560-np6nfvf2 19 2 Covid-19 covid-19 NN cord-299560-np6nfvf2 19 3 virus virus NN cord-299560-np6nfvf2 19 4 spreads spread VBZ cord-299560-np6nfvf2 19 5 mainly mainly RB cord-299560-np6nfvf2 19 6 through through IN cord-299560-np6nfvf2 19 7 saliva saliva NN cord-299560-np6nfvf2 19 8 , , , cord-299560-np6nfvf2 19 9 droplets droplet NNS cord-299560-np6nfvf2 19 10 , , , cord-299560-np6nfvf2 19 11 or or CC cord-299560-np6nfvf2 19 12 discharges discharge NNS cord-299560-np6nfvf2 19 13 from from IN cord-299560-np6nfvf2 19 14 the the DT cord-299560-np6nfvf2 19 15 nose nose NN cord-299560-np6nfvf2 19 16 of of IN cord-299560-np6nfvf2 19 17 an an DT cord-299560-np6nfvf2 19 18 infected infected JJ cord-299560-np6nfvf2 19 19 individual individual NN cord-299560-np6nfvf2 19 20 after after IN cord-299560-np6nfvf2 19 21 coughing cough VBG cord-299560-np6nfvf2 19 22 or or CC cord-299560-np6nfvf2 19 23 sneezing sneeze VBG cord-299560-np6nfvf2 19 24 ( ( -LRB- cord-299560-np6nfvf2 19 25 Pant Pant NNP cord-299560-np6nfvf2 19 26 et et FW cord-299560-np6nfvf2 19 27 al al NNP cord-299560-np6nfvf2 19 28 . . NNP cord-299560-np6nfvf2 19 29 , , , cord-299560-np6nfvf2 19 30 2020 2020 CD cord-299560-np6nfvf2 19 31 ) ) -RRB- cord-299560-np6nfvf2 19 32 . . . cord-299560-np6nfvf2 20 1 The the DT cord-299560-np6nfvf2 20 2 incubation incubation NN cord-299560-np6nfvf2 20 3 period period NN cord-299560-np6nfvf2 20 4 can can MD cord-299560-np6nfvf2 20 5 range range VB cord-299560-np6nfvf2 20 6 from from IN cord-299560-np6nfvf2 20 7 two two CD cord-299560-np6nfvf2 20 8 to to TO cord-299560-np6nfvf2 20 9 fourteen fourteen CD cord-299560-np6nfvf2 20 10 days day NNS cord-299560-np6nfvf2 21 1 ( ( -LRB- cord-299560-np6nfvf2 21 2 Abdelli Abdelli NNP cord-299560-np6nfvf2 21 3 et et NNP cord-299560-np6nfvf2 21 4 al al NNP cord-299560-np6nfvf2 21 5 . . NNP cord-299560-np6nfvf2 21 6 , , , cord-299560-np6nfvf2 21 7 2020 2020 CD cord-299560-np6nfvf2 21 8 ) ) -RRB- cord-299560-np6nfvf2 21 9 . . . cord-299560-np6nfvf2 22 1 Since since IN cord-299560-np6nfvf2 22 2 reported report VBN cord-299560-np6nfvf2 22 3 in in IN cord-299560-np6nfvf2 22 4 December December NNP cord-299560-np6nfvf2 22 5 2019 2019 CD cord-299560-np6nfvf2 22 6 , , , cord-299560-np6nfvf2 22 7 it -PRON- PRP cord-299560-np6nfvf2 22 8 has have VBZ cord-299560-np6nfvf2 22 9 infected infect VBN cord-299560-np6nfvf2 22 10 2 2 CD cord-299560-np6nfvf2 22 11 , , , cord-299560-np6nfvf2 22 12 160 160 CD cord-299560-np6nfvf2 22 13 , , , cord-299560-np6nfvf2 22 14 207 207 CD cord-299560-np6nfvf2 22 15 individuals individual NNS cord-299560-np6nfvf2 22 16 , , , cord-299560-np6nfvf2 22 17 leading lead VBG cord-299560-np6nfvf2 22 18 to to IN cord-299560-np6nfvf2 22 19 146,088 146,088 CD cord-299560-np6nfvf2 22 20 deaths death NNS cord-299560-np6nfvf2 22 21 globally globally RB cord-299560-np6nfvf2 22 22 ( ( -LRB- cord-299560-np6nfvf2 22 23 WHO who WP cord-299560-np6nfvf2 22 24 , , , cord-299560-np6nfvf2 22 25 2020a 2020a CD cord-299560-np6nfvf2 22 26 ) ) -RRB- cord-299560-np6nfvf2 22 27 . . . cord-299560-np6nfvf2 23 1 The the DT cord-299560-np6nfvf2 23 2 first first JJ cord-299560-np6nfvf2 23 3 reported reported JJ cord-299560-np6nfvf2 23 4 death death NN cord-299560-np6nfvf2 23 5 was be VBD cord-299560-np6nfvf2 23 6 on on IN cord-299560-np6nfvf2 23 7 11 11 CD cord-299560-np6nfvf2 23 8 January January NNP cord-299560-np6nfvf2 23 9 2020 2020 CD cord-299560-np6nfvf2 23 10 and and CC cord-299560-np6nfvf2 23 11 the the DT cord-299560-np6nfvf2 23 12 transmission transmission NN cord-299560-np6nfvf2 23 13 from from IN cord-299560-np6nfvf2 23 14 patients patient NNS cord-299560-np6nfvf2 23 15 to to IN cord-299560-np6nfvf2 23 16 healthcare healthcare NN cord-299560-np6nfvf2 23 17 workers worker NNS cord-299560-np6nfvf2 23 18 was be VBD cord-299560-np6nfvf2 23 19 first first RB cord-299560-np6nfvf2 23 20 documented document VBN cord-299560-np6nfvf2 23 21 on on IN cord-299560-np6nfvf2 23 22 20 20 CD cord-299560-np6nfvf2 23 23 January January NNP cord-299560-np6nfvf2 23 24 2020 2020 CD cord-299560-np6nfvf2 24 1 ( ( -LRB- cord-299560-np6nfvf2 24 2 Enmozhi Enmozhi NNP cord-299560-np6nfvf2 24 3 et et NNP cord-299560-np6nfvf2 24 4 al al NNP cord-299560-np6nfvf2 24 5 . . NNP cord-299560-np6nfvf2 24 6 , , , cord-299560-np6nfvf2 24 7 2020 2020 CD cord-299560-np6nfvf2 24 8 ) ) -RRB- cord-299560-np6nfvf2 24 9 . . . cord-299560-np6nfvf2 25 1 Moreover moreover RB cord-299560-np6nfvf2 25 2 , , , cord-299560-np6nfvf2 25 3 the the DT cord-299560-np6nfvf2 25 4 lives life NNS cord-299560-np6nfvf2 25 5 of of IN cord-299560-np6nfvf2 25 6 millions million NNS cord-299560-np6nfvf2 25 7 of of IN cord-299560-np6nfvf2 25 8 people people NNS cord-299560-np6nfvf2 25 9 have have VBP cord-299560-np6nfvf2 25 10 been be VBN cord-299560-np6nfvf2 25 11 affected affect VBN cord-299560-np6nfvf2 25 12 due due IN cord-299560-np6nfvf2 25 13 to to IN cord-299560-np6nfvf2 25 14 isolations isolation NNS cord-299560-np6nfvf2 25 15 , , , cord-299560-np6nfvf2 25 16 required require VBN cord-299560-np6nfvf2 25 17 lockdowns lockdown NNS cord-299560-np6nfvf2 25 18 , , , cord-299560-np6nfvf2 25 19 and and CC cord-299560-np6nfvf2 25 20 quarantines quarantine NNS cord-299560-np6nfvf2 25 21 . . . cord-299560-np6nfvf2 26 1 Thus thus RB cord-299560-np6nfvf2 26 2 the the DT cord-299560-np6nfvf2 26 3 dreaded dreaded JJ cord-299560-np6nfvf2 26 4 effect effect NN cord-299560-np6nfvf2 26 5 of of IN cord-299560-np6nfvf2 26 6 the the DT cord-299560-np6nfvf2 26 7 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 26 8 pandemic pandemic NN cord-299560-np6nfvf2 26 9 has have VBZ cord-299560-np6nfvf2 26 10 imposed impose VBN cord-299560-np6nfvf2 26 11 main main JJ cord-299560-np6nfvf2 26 12 challenges challenge NNS cord-299560-np6nfvf2 26 13 for for IN cord-299560-np6nfvf2 26 14 worldwide worldwide JJ cord-299560-np6nfvf2 26 15 well well RB cord-299560-np6nfvf2 26 16 - - HYPH cord-299560-np6nfvf2 26 17 being being NN cord-299560-np6nfvf2 26 18 , , , cord-299560-np6nfvf2 26 19 economy economy NN cord-299560-np6nfvf2 26 20 and and CC cord-299560-np6nfvf2 26 21 society society NN cord-299560-np6nfvf2 27 1 ( ( -LRB- cord-299560-np6nfvf2 27 2 Joshi Joshi NNP cord-299560-np6nfvf2 27 3 et et NNP cord-299560-np6nfvf2 27 4 al al NNP cord-299560-np6nfvf2 27 5 . . NNP cord-299560-np6nfvf2 27 6 , , , cord-299560-np6nfvf2 27 7 2020 2020 CD cord-299560-np6nfvf2 27 8 ; ; : cord-299560-np6nfvf2 27 9 Umesh Umesh NNP cord-299560-np6nfvf2 27 10 et et NNP cord-299560-np6nfvf2 27 11 al al NNP cord-299560-np6nfvf2 27 12 . . NNP cord-299560-np6nfvf2 27 13 , , , cord-299560-np6nfvf2 27 14 2020 2020 CD cord-299560-np6nfvf2 27 15 ) ) -RRB- cord-299560-np6nfvf2 27 16 . . . cord-299560-np6nfvf2 28 1 Coronavirus Coronavirus NNP cord-299560-np6nfvf2 28 2 is be VBZ cord-299560-np6nfvf2 28 3 lavish lavish JJ cord-299560-np6nfvf2 28 4 in in IN cord-299560-np6nfvf2 28 5 mammals mammal NNS cord-299560-np6nfvf2 28 6 and and CC cord-299560-np6nfvf2 28 7 birds bird NNS cord-299560-np6nfvf2 28 8 and and CC cord-299560-np6nfvf2 28 9 institute institute VB cord-299560-np6nfvf2 28 10 a a DT cord-299560-np6nfvf2 28 11 large large JJ cord-299560-np6nfvf2 28 12 family family NN cord-299560-np6nfvf2 28 13 of of IN cord-299560-np6nfvf2 28 14 non non JJ cord-299560-np6nfvf2 28 15 - - JJ cord-299560-np6nfvf2 28 16 segmented segmented JJ cord-299560-np6nfvf2 28 17 , , , cord-299560-np6nfvf2 28 18 enveloped envelop VBN cord-299560-np6nfvf2 28 19 , , , cord-299560-np6nfvf2 28 20 positive positive JJ cord-299560-np6nfvf2 28 21 - - HYPH cord-299560-np6nfvf2 28 22 sense sense NN cord-299560-np6nfvf2 28 23 , , , cord-299560-np6nfvf2 28 24 single single RB cord-299560-np6nfvf2 28 25 - - HYPH cord-299560-np6nfvf2 28 26 stranded strand VBN cord-299560-np6nfvf2 28 27 RNA RNA NNP cord-299560-np6nfvf2 28 28 betacoronavirus betacoronavirus NN cord-299560-np6nfvf2 28 29 of of IN cord-299560-np6nfvf2 28 30 the the DT cord-299560-np6nfvf2 28 31 family family NN cord-299560-np6nfvf2 28 32 Coronaviridae Coronaviridae NNP cord-299560-np6nfvf2 28 33 ( ( -LRB- cord-299560-np6nfvf2 28 34 Schoeman Schoeman NNP cord-299560-np6nfvf2 28 35 & & CC cord-299560-np6nfvf2 28 36 Fielding Fielding NNP cord-299560-np6nfvf2 28 37 , , , cord-299560-np6nfvf2 28 38 2019 2019 CD cord-299560-np6nfvf2 28 39 ) ) -RRB- cord-299560-np6nfvf2 28 40 , , , cord-299560-np6nfvf2 28 41 and and CC cord-299560-np6nfvf2 28 42 has have VBZ cord-299560-np6nfvf2 28 43 a a DT cord-299560-np6nfvf2 28 44 high high JJ cord-299560-np6nfvf2 28 45 frequency frequency NN cord-299560-np6nfvf2 28 46 of of IN cord-299560-np6nfvf2 28 47 genomic genomic JJ cord-299560-np6nfvf2 28 48 recombination recombination NN cord-299560-np6nfvf2 28 49 and and CC cord-299560-np6nfvf2 28 50 mutation mutation NN cord-299560-np6nfvf2 28 51 ( ( -LRB- cord-299560-np6nfvf2 28 52 Khan Khan NNP cord-299560-np6nfvf2 28 53 , , , cord-299560-np6nfvf2 28 54 Zia Zia NNP cord-299560-np6nfvf2 28 55 , , , cord-299560-np6nfvf2 29 1 et et NNP cord-299560-np6nfvf2 29 2 al al NNP cord-299560-np6nfvf2 29 3 . . NNP cord-299560-np6nfvf2 29 4 , , , cord-299560-np6nfvf2 29 5 2020 2020 CD cord-299560-np6nfvf2 29 6 ) ) -RRB- cord-299560-np6nfvf2 29 7 . . . cord-299560-np6nfvf2 30 1 This this DT cord-299560-np6nfvf2 30 2 genetic genetic JJ cord-299560-np6nfvf2 30 3 modification modification NN cord-299560-np6nfvf2 30 4 of of IN cord-299560-np6nfvf2 30 5 CoV CoV NNP cord-299560-np6nfvf2 30 6 can can MD cord-299560-np6nfvf2 30 7 hinder hinder VB cord-299560-np6nfvf2 30 8 the the DT cord-299560-np6nfvf2 30 9 production production NN cord-299560-np6nfvf2 30 10 of of IN cord-299560-np6nfvf2 30 11 efficient efficient JJ cord-299560-np6nfvf2 30 12 vaccine vaccine NN cord-299560-np6nfvf2 30 13 ( ( -LRB- cord-299560-np6nfvf2 30 14 Hasan Hasan NNP cord-299560-np6nfvf2 30 15 et et NNP cord-299560-np6nfvf2 30 16 al al NNP cord-299560-np6nfvf2 30 17 . . NNP cord-299560-np6nfvf2 30 18 , , , cord-299560-np6nfvf2 30 19 2020 2020 CD cord-299560-np6nfvf2 30 20 ) ) -RRB- cord-299560-np6nfvf2 30 21 . . . cord-299560-np6nfvf2 31 1 Bats bat NNS cord-299560-np6nfvf2 31 2 are be VBP cord-299560-np6nfvf2 31 3 the the DT cord-299560-np6nfvf2 31 4 main main JJ cord-299560-np6nfvf2 31 5 harbor harbor NN cord-299560-np6nfvf2 31 6 to to IN cord-299560-np6nfvf2 31 7 the the DT cord-299560-np6nfvf2 31 8 ultimate ultimate JJ cord-299560-np6nfvf2 31 9 variety variety NN cord-299560-np6nfvf2 31 10 of of IN cord-299560-np6nfvf2 31 11 genotypes genotype NNS cord-299560-np6nfvf2 31 12 with with IN cord-299560-np6nfvf2 31 13 spread spread NN cord-299560-np6nfvf2 31 14 via via IN cord-299560-np6nfvf2 31 15 an an DT cord-299560-np6nfvf2 31 16 unknown unknown JJ cord-299560-np6nfvf2 31 17 intermediate intermediate JJ cord-299560-np6nfvf2 31 18 mammal mammal NN cord-299560-np6nfvf2 31 19 host host NN cord-299560-np6nfvf2 31 20 to to IN cord-299560-np6nfvf2 31 21 humans human NNS cord-299560-np6nfvf2 31 22 . . . cord-299560-np6nfvf2 32 1 Overall overall RB cord-299560-np6nfvf2 32 2 , , , cord-299560-np6nfvf2 32 3 human human JJ cord-299560-np6nfvf2 32 4 and and CC cord-299560-np6nfvf2 32 5 animal animal NN cord-299560-np6nfvf2 32 6 coronavirus coronavirus NN cord-299560-np6nfvf2 32 7 comprises comprise VBZ cord-299560-np6nfvf2 32 8 of of IN cord-299560-np6nfvf2 32 9 four four CD cord-299560-np6nfvf2 32 10 genera genus NNS cord-299560-np6nfvf2 32 11 namely namely RB cord-299560-np6nfvf2 32 12 a a DT cord-299560-np6nfvf2 32 13 , , , cord-299560-np6nfvf2 32 14 b b NN cord-299560-np6nfvf2 32 15 , , , cord-299560-np6nfvf2 32 16 c c NN cord-299560-np6nfvf2 32 17 and and CC cord-299560-np6nfvf2 32 18 d d NN cord-299560-np6nfvf2 32 19 coronavirus coronavirus NN cord-299560-np6nfvf2 32 20 genus genus NN cord-299560-np6nfvf2 32 21 ( ( -LRB- cord-299560-np6nfvf2 32 22 Sinha Sinha NNP cord-299560-np6nfvf2 32 23 et et NNP cord-299560-np6nfvf2 32 24 al al NNP cord-299560-np6nfvf2 32 25 . . NNP cord-299560-np6nfvf2 32 26 , , , cord-299560-np6nfvf2 32 27 2020 2020 CD cord-299560-np6nfvf2 32 28 ) ) -RRB- cord-299560-np6nfvf2 32 29 . . . cord-299560-np6nfvf2 33 1 The the DT cord-299560-np6nfvf2 33 2 b b NN cord-299560-np6nfvf2 33 3 coronavirus coronavirus NN cord-299560-np6nfvf2 33 4 includes include VBZ cord-299560-np6nfvf2 33 5 the the DT cord-299560-np6nfvf2 33 6 Middle Middle NNP cord-299560-np6nfvf2 33 7 East East NNP cord-299560-np6nfvf2 33 8 respiratory respiratory JJ cord-299560-np6nfvf2 33 9 syndrome syndrome NN cord-299560-np6nfvf2 33 10 ( ( -LRB- cord-299560-np6nfvf2 33 11 MERS MERS NNP cord-299560-np6nfvf2 33 12 ) ) -RRB- cord-299560-np6nfvf2 33 13 , , , cord-299560-np6nfvf2 33 14 severe severe JJ cord-299560-np6nfvf2 33 15 acute acute JJ cord-299560-np6nfvf2 33 16 respiratory respiratory JJ cord-299560-np6nfvf2 33 17 syndrome syndrome NN cord-299560-np6nfvf2 33 18 ( ( -LRB- cord-299560-np6nfvf2 33 19 SARS SARS NNP cord-299560-np6nfvf2 33 20 ) ) -RRB- cord-299560-np6nfvf2 33 21 , , , cord-299560-np6nfvf2 33 22 and and CC cord-299560-np6nfvf2 33 23 SARS SARS NNP cord-299560-np6nfvf2 33 24 - - HYPH cord-299560-np6nfvf2 33 25 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 33 26 ( ( -LRB- cord-299560-np6nfvf2 33 27 Khan Khan NNP cord-299560-np6nfvf2 33 28 , , , cord-299560-np6nfvf2 33 29 Jha Jha NNP cord-299560-np6nfvf2 33 30 , , , cord-299560-np6nfvf2 33 31 et et NNP cord-299560-np6nfvf2 33 32 al al NNP cord-299560-np6nfvf2 33 33 . . NNP cord-299560-np6nfvf2 33 34 , , , cord-299560-np6nfvf2 33 35 2020 2020 CD cord-299560-np6nfvf2 33 36 ; ; . cord-299560-np6nfvf2 34 1 Sahu Sahu NNP cord-299560-np6nfvf2 34 2 et et FW cord-299560-np6nfvf2 34 3 al al NNP cord-299560-np6nfvf2 34 4 . . NNP cord-299560-np6nfvf2 34 5 , , , cord-299560-np6nfvf2 34 6 2020 2020 CD cord-299560-np6nfvf2 34 7 ) ) -RRB- cord-299560-np6nfvf2 34 8 . . . cord-299560-np6nfvf2 35 1 The the DT cord-299560-np6nfvf2 35 2 CoV cov NN cord-299560-np6nfvf2 35 3 family family NN cord-299560-np6nfvf2 35 4 has have VBZ cord-299560-np6nfvf2 35 5 a a DT cord-299560-np6nfvf2 35 6 sizable sizable JJ cord-299560-np6nfvf2 35 7 homogeneous homogeneous JJ cord-299560-np6nfvf2 35 8 " " `` cord-299560-np6nfvf2 35 9 spike spike NN cord-299560-np6nfvf2 35 10 protein protein NN cord-299560-np6nfvf2 35 11 " " '' cord-299560-np6nfvf2 35 12 ( ( -LRB- cord-299560-np6nfvf2 35 13 Figure figure NN cord-299560-np6nfvf2 35 14 1 1 CD cord-299560-np6nfvf2 35 15 ) ) -RRB- cord-299560-np6nfvf2 35 16 . . . cord-299560-np6nfvf2 36 1 The the DT cord-299560-np6nfvf2 36 2 role role NN cord-299560-np6nfvf2 36 3 of of IN cord-299560-np6nfvf2 36 4 the the DT cord-299560-np6nfvf2 36 5 spike spike NN cord-299560-np6nfvf2 36 6 ( ( -LRB- cord-299560-np6nfvf2 36 7 S s NN cord-299560-np6nfvf2 36 8 ) ) -RRB- cord-299560-np6nfvf2 36 9 protein protein NN cord-299560-np6nfvf2 36 10 , , , cord-299560-np6nfvf2 36 11 which which WDT cord-299560-np6nfvf2 36 12 is be VBZ cord-299560-np6nfvf2 36 13 composed compose VBN cord-299560-np6nfvf2 36 14 of of IN cord-299560-np6nfvf2 36 15 1300 1300 CD cord-299560-np6nfvf2 36 16 amino amino NN cord-299560-np6nfvf2 36 17 acids acid NNS cord-299560-np6nfvf2 36 18 ( ( -LRB- cord-299560-np6nfvf2 36 19 Elfiky Elfiky NNP cord-299560-np6nfvf2 36 20 , , , cord-299560-np6nfvf2 36 21 2020b 2020b CD cord-299560-np6nfvf2 36 22 ) ) -RRB- cord-299560-np6nfvf2 36 23 , , , cord-299560-np6nfvf2 36 24 is be VBZ cord-299560-np6nfvf2 36 25 to to TO cord-299560-np6nfvf2 36 26 interact interact VB cord-299560-np6nfvf2 36 27 with with IN cord-299560-np6nfvf2 36 28 the the DT cord-299560-np6nfvf2 36 29 host host NN cord-299560-np6nfvf2 36 30 cells cell NNS cord-299560-np6nfvf2 36 31 , , , cord-299560-np6nfvf2 36 32 such such JJ cord-299560-np6nfvf2 36 33 as as IN cord-299560-np6nfvf2 36 34 the the DT cord-299560-np6nfvf2 36 35 pulmonary pulmonary JJ cord-299560-np6nfvf2 36 36 and and CC cord-299560-np6nfvf2 36 37 parabronchial parabronchial JJ cord-299560-np6nfvf2 36 38 epithelial epithelial JJ cord-299560-np6nfvf2 36 39 cell cell NN cord-299560-np6nfvf2 36 40 , , , cord-299560-np6nfvf2 36 41 and and CC cord-299560-np6nfvf2 36 42 assists assist VBZ cord-299560-np6nfvf2 36 43 the the DT cord-299560-np6nfvf2 36 44 coronavirus coronavirus NN cord-299560-np6nfvf2 36 45 to to TO cord-299560-np6nfvf2 36 46 enter enter VB cord-299560-np6nfvf2 36 47 through through IN cord-299560-np6nfvf2 36 48 the the DT cord-299560-np6nfvf2 36 49 epithelial epithelial JJ cord-299560-np6nfvf2 36 50 cell cell NN cord-299560-np6nfvf2 36 51 membrane membrane NN cord-299560-np6nfvf2 36 52 ( ( -LRB- cord-299560-np6nfvf2 36 53 Boopathi Boopathi NNP cord-299560-np6nfvf2 36 54 et et NNP cord-299560-np6nfvf2 36 55 al al NNP cord-299560-np6nfvf2 36 56 . . NNP cord-299560-np6nfvf2 36 57 , , , cord-299560-np6nfvf2 36 58 2020 2020 CD cord-299560-np6nfvf2 36 59 ; ; : cord-299560-np6nfvf2 36 60 Xia Xia NNP cord-299560-np6nfvf2 36 61 et et NNP cord-299560-np6nfvf2 36 62 al al NNP cord-299560-np6nfvf2 36 63 . . NNP cord-299560-np6nfvf2 36 64 , , , cord-299560-np6nfvf2 36 65 2020 2020 CD cord-299560-np6nfvf2 36 66 ) ) -RRB- cord-299560-np6nfvf2 36 67 . . . cord-299560-np6nfvf2 37 1 Moreover moreover RB cord-299560-np6nfvf2 37 2 , , , cord-299560-np6nfvf2 37 3 the the DT cord-299560-np6nfvf2 37 4 alveolar alveolar JJ cord-299560-np6nfvf2 37 5 epithelial epithelial JJ cord-299560-np6nfvf2 37 6 cells cell NNS cord-299560-np6nfvf2 37 7 have have VBP cord-299560-np6nfvf2 37 8 ample ample JJ cord-299560-np6nfvf2 37 9 expression expression NN cord-299560-np6nfvf2 37 10 of of IN cord-299560-np6nfvf2 37 11 angiotensin angiotensin NN cord-299560-np6nfvf2 37 12 - - HYPH cord-299560-np6nfvf2 37 13 converting convert VBG cord-299560-np6nfvf2 37 14 enzyme enzyme NN cord-299560-np6nfvf2 37 15 2 2 CD cord-299560-np6nfvf2 37 16 ( ( -LRB- cord-299560-np6nfvf2 37 17 ACE2 ACE2 NNP cord-299560-np6nfvf2 37 18 ) ) -RRB- cord-299560-np6nfvf2 37 19 , , , cord-299560-np6nfvf2 37 20 which which WDT cord-299560-np6nfvf2 37 21 is be VBZ cord-299560-np6nfvf2 37 22 an an DT cord-299560-np6nfvf2 37 23 aim aim NN cord-299560-np6nfvf2 37 24 by by IN cord-299560-np6nfvf2 37 25 the the DT cord-299560-np6nfvf2 37 26 virus virus NN cord-299560-np6nfvf2 37 27 . . . cord-299560-np6nfvf2 38 1 The the DT cord-299560-np6nfvf2 38 2 detection detection NN cord-299560-np6nfvf2 38 3 of of IN cord-299560-np6nfvf2 38 4 ACE2 ACE2 NNP cord-299560-np6nfvf2 38 5 by by IN cord-299560-np6nfvf2 38 6 the the DT cord-299560-np6nfvf2 38 7 S S NNP cord-299560-np6nfvf2 38 8 protein protein NN cord-299560-np6nfvf2 38 9 of of IN cord-299560-np6nfvf2 38 10 the the DT cord-299560-np6nfvf2 38 11 virus virus NN cord-299560-np6nfvf2 38 12 permits permit VBZ cord-299560-np6nfvf2 38 13 the the DT cord-299560-np6nfvf2 38 14 invasion invasion NN cord-299560-np6nfvf2 38 15 of of IN cord-299560-np6nfvf2 38 16 the the DT cord-299560-np6nfvf2 38 17 coronavirus coronavirus NN cord-299560-np6nfvf2 38 18 into into IN cord-299560-np6nfvf2 38 19 the the DT cord-299560-np6nfvf2 38 20 human human JJ cord-299560-np6nfvf2 38 21 circulation circulation NN cord-299560-np6nfvf2 38 22 system system NN cord-299560-np6nfvf2 38 23 ( ( -LRB- cord-299560-np6nfvf2 38 24 Belouzard Belouzard NNP cord-299560-np6nfvf2 38 25 et et NNP cord-299560-np6nfvf2 38 26 al al NNP cord-299560-np6nfvf2 38 27 . . NNP cord-299560-np6nfvf2 38 28 , , , cord-299560-np6nfvf2 38 29 2009 2009 CD cord-299560-np6nfvf2 38 30 ) ) -RRB- cord-299560-np6nfvf2 38 31 . . . cord-299560-np6nfvf2 39 1 Single single JJ cord-299560-np6nfvf2 39 2 - - HYPH cord-299560-np6nfvf2 39 3 strand strand NN cord-299560-np6nfvf2 39 4 RNA RNA NNP cord-299560-np6nfvf2 39 5 ( ( -LRB- cord-299560-np6nfvf2 39 6 22 22 CD cord-299560-np6nfvf2 39 7 - - SYM cord-299560-np6nfvf2 39 8 26 26 CD cord-299560-np6nfvf2 39 9 kilobases kilobase NNS cord-299560-np6nfvf2 39 10 ) ) -RRB- cord-299560-np6nfvf2 39 11 viruses virus NNS cord-299560-np6nfvf2 39 12 such such JJ cord-299560-np6nfvf2 39 13 as as IN cord-299560-np6nfvf2 39 14 the the DT cord-299560-np6nfvf2 39 15 coronavirus coronavirus NN cord-299560-np6nfvf2 39 16 family family NN cord-299560-np6nfvf2 39 17 reproduce reproduce VB cord-299560-np6nfvf2 39 18 the the DT cord-299560-np6nfvf2 39 19 virus virus NN cord-299560-np6nfvf2 39 20 genomes genome NNS cord-299560-np6nfvf2 39 21 by by IN cord-299560-np6nfvf2 39 22 capitalizing capitalize VBG cord-299560-np6nfvf2 39 23 on on IN cord-299560-np6nfvf2 39 24 host host NN cord-299560-np6nfvf2 39 25 cells cell NNS cord-299560-np6nfvf2 39 26 . . . cord-299560-np6nfvf2 40 1 For for IN cord-299560-np6nfvf2 40 2 instance instance NN cord-299560-np6nfvf2 40 3 , , , cord-299560-np6nfvf2 40 4 after after IN cord-299560-np6nfvf2 40 5 coronavirus coronavirus NN cord-299560-np6nfvf2 40 6 comes come VBZ cord-299560-np6nfvf2 40 7 near near IN cord-299560-np6nfvf2 40 8 the the DT cord-299560-np6nfvf2 40 9 ribosome ribosome NN cord-299560-np6nfvf2 40 10 of of IN cord-299560-np6nfvf2 40 11 the the DT cord-299560-np6nfvf2 40 12 epithelial epithelial JJ cord-299560-np6nfvf2 40 13 cells cell NNS cord-299560-np6nfvf2 40 14 or or CC cord-299560-np6nfvf2 40 15 other other JJ cord-299560-np6nfvf2 40 16 host host NN cord-299560-np6nfvf2 40 17 cells cell NNS cord-299560-np6nfvf2 40 18 , , , cord-299560-np6nfvf2 40 19 it -PRON- PRP cord-299560-np6nfvf2 40 20 utilizes utilize VBZ cord-299560-np6nfvf2 40 21 the the DT cord-299560-np6nfvf2 40 22 ribosome ribosome NN cord-299560-np6nfvf2 40 23 of of IN cord-299560-np6nfvf2 40 24 the the DT cord-299560-np6nfvf2 40 25 host host NN cord-299560-np6nfvf2 40 26 cell cell NN cord-299560-np6nfvf2 40 27 to to TO cord-299560-np6nfvf2 40 28 replicate replicate VB cord-299560-np6nfvf2 40 29 polyproteins polyprotein NNS cord-299560-np6nfvf2 40 30 . . . cord-299560-np6nfvf2 41 1 The the DT cord-299560-np6nfvf2 41 2 replication replication NN cord-299560-np6nfvf2 41 3 and and CC cord-299560-np6nfvf2 41 4 ensuing ensue VBG cord-299560-np6nfvf2 41 5 procedures procedure NNS cord-299560-np6nfvf2 41 6 of of IN cord-299560-np6nfvf2 41 7 precursor precursor NN cord-299560-np6nfvf2 41 8 polyproteins polyprotein NNS cord-299560-np6nfvf2 41 9 can can MD cord-299560-np6nfvf2 41 10 arise arise VB cord-299560-np6nfvf2 41 11 in in IN cord-299560-np6nfvf2 41 12 the the DT cord-299560-np6nfvf2 41 13 epithelial epithelial JJ cord-299560-np6nfvf2 41 14 cells cell NNS cord-299560-np6nfvf2 42 1 ( ( -LRB- cord-299560-np6nfvf2 42 2 Hoffmann Hoffmann NNP cord-299560-np6nfvf2 42 3 et et NNP cord-299560-np6nfvf2 42 4 al al NNP cord-299560-np6nfvf2 42 5 . . NNP cord-299560-np6nfvf2 42 6 , , , cord-299560-np6nfvf2 42 7 2020 2020 CD cord-299560-np6nfvf2 42 8 ; ; : cord-299560-np6nfvf2 42 9 Wahedi Wahedi NNP cord-299560-np6nfvf2 42 10 et et NNP cord-299560-np6nfvf2 42 11 al al NNP cord-299560-np6nfvf2 42 12 . . NNP cord-299560-np6nfvf2 42 13 , , , cord-299560-np6nfvf2 42 14 2020 2020 CD cord-299560-np6nfvf2 42 15 ) ) -RRB- cord-299560-np6nfvf2 42 16 . . . cord-299560-np6nfvf2 43 1 After after IN cord-299560-np6nfvf2 43 2 the the DT cord-299560-np6nfvf2 43 3 coronavirus coronavirus NN cord-299560-np6nfvf2 43 4 polyproteins polyprotein NNS cord-299560-np6nfvf2 43 5 are be VBP cord-299560-np6nfvf2 43 6 exhibited exhibit VBN cord-299560-np6nfvf2 43 7 , , , cord-299560-np6nfvf2 43 8 two two CD cord-299560-np6nfvf2 43 9 enzymes enzyme NNS cord-299560-np6nfvf2 43 10 , , , cord-299560-np6nfvf2 43 11 coronavirus coronavirus NN cord-299560-np6nfvf2 43 12 main main JJ cord-299560-np6nfvf2 43 13 proteinase proteinase NN cord-299560-np6nfvf2 43 14 ( ( -LRB- cord-299560-np6nfvf2 43 15 3CLpro 3clpro CD cord-299560-np6nfvf2 43 16 ) ) -RRB- cord-299560-np6nfvf2 43 17 and and CC cord-299560-np6nfvf2 43 18 the the DT cord-299560-np6nfvf2 43 19 papain papain NN cord-299560-np6nfvf2 43 20 - - HYPH cord-299560-np6nfvf2 43 21 like like JJ cord-299560-np6nfvf2 43 22 protease protease NN cord-299560-np6nfvf2 43 23 ( ( -LRB- cord-299560-np6nfvf2 43 24 PLpro PLpro NNP cord-299560-np6nfvf2 43 25 ) ) -RRB- cord-299560-np6nfvf2 43 26 are be VBP cord-299560-np6nfvf2 43 27 believed believe VBN cord-299560-np6nfvf2 43 28 to to TO cord-299560-np6nfvf2 43 29 be be VB cord-299560-np6nfvf2 43 30 involved involve VBN cord-299560-np6nfvf2 43 31 in in IN cord-299560-np6nfvf2 43 32 cleaving cleave VBG cord-299560-np6nfvf2 43 33 the the DT cord-299560-np6nfvf2 43 34 polyproteins polyprotein NNS cord-299560-np6nfvf2 43 35 into into IN cord-299560-np6nfvf2 43 36 smaller small JJR cord-299560-np6nfvf2 43 37 products product NNS cord-299560-np6nfvf2 43 38 used use VBN cord-299560-np6nfvf2 43 39 for for IN cord-299560-np6nfvf2 43 40 replicating replicate VBG cord-299560-np6nfvf2 43 41 new new JJ cord-299560-np6nfvf2 43 42 viruses virus NNS cord-299560-np6nfvf2 43 43 . . . cord-299560-np6nfvf2 44 1 In in IN cord-299560-np6nfvf2 44 2 order order NN cord-299560-np6nfvf2 44 3 to to TO cord-299560-np6nfvf2 44 4 produce produce VB cord-299560-np6nfvf2 44 5 the the DT cord-299560-np6nfvf2 44 6 daughter daughter NN cord-299560-np6nfvf2 44 7 RNA RNA NNP cord-299560-np6nfvf2 44 8 genome genome NN cord-299560-np6nfvf2 44 9 , , , cord-299560-np6nfvf2 44 10 the the DT cord-299560-np6nfvf2 44 11 coronavirus coronavirus NN cord-299560-np6nfvf2 44 12 exhibits exhibit VBZ cord-299560-np6nfvf2 44 13 an an DT cord-299560-np6nfvf2 44 14 RNA RNA NNP cord-299560-np6nfvf2 44 15 - - HYPH cord-299560-np6nfvf2 44 16 dependent dependent JJ cord-299560-np6nfvf2 44 17 RNA RNA NNP cord-299560-np6nfvf2 44 18 polymerase polymerase NN cord-299560-np6nfvf2 44 19 ( ( -LRB- cord-299560-np6nfvf2 44 20 RdRp RdRp NNP cord-299560-np6nfvf2 44 21 ) ) -RRB- cord-299560-np6nfvf2 44 22 , , , cord-299560-np6nfvf2 44 23 which which WDT cord-299560-np6nfvf2 44 24 is be VBZ cord-299560-np6nfvf2 44 25 an an DT cord-299560-np6nfvf2 44 26 important important JJ cord-299560-np6nfvf2 44 27 replicase replicase NN cord-299560-np6nfvf2 44 28 that that WDT cord-299560-np6nfvf2 44 29 catalyzes catalyze VBZ cord-299560-np6nfvf2 44 30 the the DT cord-299560-np6nfvf2 44 31 synthesis synthesis NN cord-299560-np6nfvf2 44 32 of of IN cord-299560-np6nfvf2 44 33 a a DT cord-299560-np6nfvf2 44 34 complementary complementary JJ cord-299560-np6nfvf2 44 35 RNA RNA NNP cord-299560-np6nfvf2 44 36 strand strand NN cord-299560-np6nfvf2 44 37 using use VBG cord-299560-np6nfvf2 44 38 the the DT cord-299560-np6nfvf2 44 39 virus virus NN cord-299560-np6nfvf2 44 40 RNA RNA NNP cord-299560-np6nfvf2 44 41 ( ( -LRB- cord-299560-np6nfvf2 44 42 Wrapp Wrapp NNP cord-299560-np6nfvf2 44 43 et et NNP cord-299560-np6nfvf2 44 44 al al NNP cord-299560-np6nfvf2 44 45 . . NNP cord-299560-np6nfvf2 44 46 , , , cord-299560-np6nfvf2 44 47 2020 2020 CD cord-299560-np6nfvf2 44 48 ) ) -RRB- cord-299560-np6nfvf2 44 49 . . . cord-299560-np6nfvf2 45 1 CoVs CoVs NNP cord-299560-np6nfvf2 45 2 gather gather VBP cord-299560-np6nfvf2 45 3 together together RB cord-299560-np6nfvf2 45 4 near near IN cord-299560-np6nfvf2 45 5 intracellular intracellular JJ cord-299560-np6nfvf2 45 6 membranes membrane NNS cord-299560-np6nfvf2 45 7 within within IN cord-299560-np6nfvf2 45 8 the the DT cord-299560-np6nfvf2 45 9 Endoplasmic Endoplasmic NNP cord-299560-np6nfvf2 45 10 reticulum reticulum NN cord-299560-np6nfvf2 45 11 - - : cord-299560-np6nfvf2 45 12 Golgi Golgi NNP cord-299560-np6nfvf2 45 13 intermediate intermediate JJ cord-299560-np6nfvf2 45 14 compartment compartment NN cord-299560-np6nfvf2 45 15 ( ( -LRB- cord-299560-np6nfvf2 45 16 or or CC cord-299560-np6nfvf2 45 17 ERGIC ERGIC NNP cord-299560-np6nfvf2 45 18 ) ) -RRB- cord-299560-np6nfvf2 45 19 after after IN cord-299560-np6nfvf2 45 20 infection infection NN cord-299560-np6nfvf2 45 21 . . . cord-299560-np6nfvf2 46 1 Here here RB cord-299560-np6nfvf2 46 2 they -PRON- PRP cord-299560-np6nfvf2 46 3 bud bud VBP cord-299560-np6nfvf2 46 4 within within IN cord-299560-np6nfvf2 46 5 the the DT cord-299560-np6nfvf2 46 6 lumen lumen NN cord-299560-np6nfvf2 46 7 and and CC cord-299560-np6nfvf2 46 8 eventually eventually RB cord-299560-np6nfvf2 46 9 carried carry VBN cord-299560-np6nfvf2 46 10 outside outside IN cord-299560-np6nfvf2 46 11 the the DT cord-299560-np6nfvf2 46 12 cell cell NN cord-299560-np6nfvf2 46 13 through through IN cord-299560-np6nfvf2 46 14 ' ' `` cord-299560-np6nfvf2 46 15 exocytosis exocytosis NN cord-299560-np6nfvf2 46 16 ' ' '' cord-299560-np6nfvf2 46 17 within within IN cord-299560-np6nfvf2 46 18 vesicles vesicle NNS cord-299560-np6nfvf2 46 19 ( ( -LRB- cord-299560-np6nfvf2 46 20 Gupta Gupta NNP cord-299560-np6nfvf2 46 21 et et NNP cord-299560-np6nfvf2 46 22 al al NNP cord-299560-np6nfvf2 46 23 . . NNP cord-299560-np6nfvf2 46 24 , , , cord-299560-np6nfvf2 46 25 2020 2020 CD cord-299560-np6nfvf2 46 26 ) ) -RRB- cord-299560-np6nfvf2 46 27 . . . cord-299560-np6nfvf2 47 1 Replication replication NN cord-299560-np6nfvf2 47 2 of of IN cord-299560-np6nfvf2 47 3 SARS SARS NNP cord-299560-np6nfvf2 47 4 - - HYPH cord-299560-np6nfvf2 47 5 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 47 6 depends depend VBZ cord-299560-np6nfvf2 47 7 on on IN cord-299560-np6nfvf2 47 8 the the DT cord-299560-np6nfvf2 47 9 viral viral JJ cord-299560-np6nfvf2 47 10 RNAdependent RNAdependent NNP cord-299560-np6nfvf2 47 11 RNA RNA NNP cord-299560-np6nfvf2 47 12 polymerase polymerase NN cord-299560-np6nfvf2 47 13 ( ( -LRB- cord-299560-np6nfvf2 47 14 RdRp RdRp NNP cord-299560-np6nfvf2 47 15 ) ) -RRB- cord-299560-np6nfvf2 47 16 ( ( -LRB- cord-299560-np6nfvf2 47 17 Elfiky Elfiky NNP cord-299560-np6nfvf2 47 18 & & CC cord-299560-np6nfvf2 47 19 Azzam Azzam NNP cord-299560-np6nfvf2 47 20 , , , cord-299560-np6nfvf2 47 21 2020 2020 CD cord-299560-np6nfvf2 47 22 ) ) -RRB- cord-299560-np6nfvf2 47 23 which which WDT cord-299560-np6nfvf2 47 24 is be VBZ cord-299560-np6nfvf2 47 25 the the DT cord-299560-np6nfvf2 47 26 most most RBS cord-299560-np6nfvf2 47 27 probable probable JJ cord-299560-np6nfvf2 47 28 target target NN cord-299560-np6nfvf2 47 29 of of IN cord-299560-np6nfvf2 47 30 the the DT cord-299560-np6nfvf2 47 31 investigational investigational JJ cord-299560-np6nfvf2 47 32 nucleotide nucleotide NN cord-299560-np6nfvf2 47 33 analogue analogue NN cord-299560-np6nfvf2 47 34 remdesivir remdesivir NNP cord-299560-np6nfvf2 47 35 ( ( -LRB- cord-299560-np6nfvf2 47 36 RDV RDV NNP cord-299560-np6nfvf2 47 37 ) ) -RRB- cord-299560-np6nfvf2 47 38 ( ( -LRB- cord-299560-np6nfvf2 47 39 Agostini Agostini NNP cord-299560-np6nfvf2 47 40 et et NNP cord-299560-np6nfvf2 47 41 al al NNP cord-299560-np6nfvf2 47 42 . . . cord-299560-np6nfvf2 48 1 , , , cord-299560-np6nfvf2 48 2 2018 2018 CD cord-299560-np6nfvf2 48 3 ; ; : cord-299560-np6nfvf2 48 4 Jordan Jordan NNP cord-299560-np6nfvf2 48 5 et et NNP cord-299560-np6nfvf2 48 6 al al NNP cord-299560-np6nfvf2 48 7 . . NNP cord-299560-np6nfvf2 48 8 , , , cord-299560-np6nfvf2 48 9 2018 2018 CD cord-299560-np6nfvf2 48 10 ; ; : cord-299560-np6nfvf2 48 11 Siegel Siegel NNP cord-299560-np6nfvf2 48 12 et et NNP cord-299560-np6nfvf2 48 13 al al NNP cord-299560-np6nfvf2 48 14 . . . cord-299560-np6nfvf2 49 1 , , , cord-299560-np6nfvf2 49 2 2017 2017 CD cord-299560-np6nfvf2 49 3 ; ; : cord-299560-np6nfvf2 49 4 Tchesnokov Tchesnokov NNP cord-299560-np6nfvf2 49 5 et et NNP cord-299560-np6nfvf2 49 6 al al NNP cord-299560-np6nfvf2 49 7 . . NNP cord-299560-np6nfvf2 49 8 , , , cord-299560-np6nfvf2 49 9 2019 2019 CD cord-299560-np6nfvf2 49 10 ) ) -RRB- cord-299560-np6nfvf2 49 11 . . . cord-299560-np6nfvf2 50 1 After after IN cord-299560-np6nfvf2 50 2 the the DT cord-299560-np6nfvf2 50 3 outbreak outbreak NN cord-299560-np6nfvf2 50 4 , , , cord-299560-np6nfvf2 50 5 many many JJ cord-299560-np6nfvf2 50 6 kinds kind NNS cord-299560-np6nfvf2 50 7 of of IN cord-299560-np6nfvf2 50 8 medications medication NNS cord-299560-np6nfvf2 50 9 alone alone RB cord-299560-np6nfvf2 50 10 or or CC cord-299560-np6nfvf2 50 11 as as IN cord-299560-np6nfvf2 50 12 adjuvant adjuvant JJ cord-299560-np6nfvf2 50 13 have have VBP cord-299560-np6nfvf2 50 14 been be VBN cord-299560-np6nfvf2 50 15 used use VBN cord-299560-np6nfvf2 50 16 in in IN cord-299560-np6nfvf2 50 17 many many JJ cord-299560-np6nfvf2 50 18 countries country NNS cord-299560-np6nfvf2 50 19 ( ( -LRB- cord-299560-np6nfvf2 50 20 Islam Islam NNP cord-299560-np6nfvf2 50 21 et et NNP cord-299560-np6nfvf2 50 22 al al NNP cord-299560-np6nfvf2 50 23 . . NNP cord-299560-np6nfvf2 50 24 , , , cord-299560-np6nfvf2 50 25 2020 2020 CD cord-299560-np6nfvf2 50 26 ) ) -RRB- cord-299560-np6nfvf2 50 27 . . . cord-299560-np6nfvf2 51 1 The the DT cord-299560-np6nfvf2 51 2 usage usage NN cord-299560-np6nfvf2 51 3 of of IN cord-299560-np6nfvf2 51 4 already already RB cord-299560-np6nfvf2 51 5 known know VBN cord-299560-np6nfvf2 51 6 viral viral JJ cord-299560-np6nfvf2 51 7 treatments treatment NNS cord-299560-np6nfvf2 51 8 have have VBP cord-299560-np6nfvf2 51 9 many many JJ cord-299560-np6nfvf2 51 10 advantages advantage NNS cord-299560-np6nfvf2 51 11 as as IN cord-299560-np6nfvf2 51 12 the the DT cord-299560-np6nfvf2 51 13 pharmacodynamics pharmacodynamic NNS cord-299560-np6nfvf2 51 14 , , , cord-299560-np6nfvf2 51 15 pharmacokinetics pharmacokinetic NNS cord-299560-np6nfvf2 51 16 , , , cord-299560-np6nfvf2 51 17 and and CC cord-299560-np6nfvf2 51 18 safety safety NN cord-299560-np6nfvf2 51 19 profiles profile NNS cord-299560-np6nfvf2 51 20 of of IN cord-299560-np6nfvf2 51 21 these these DT cord-299560-np6nfvf2 51 22 medications medication NNS cord-299560-np6nfvf2 51 23 have have VBP cord-299560-np6nfvf2 51 24 already already RB cord-299560-np6nfvf2 51 25 been be VBN cord-299560-np6nfvf2 51 26 recognized recognize VBN cord-299560-np6nfvf2 51 27 ( ( -LRB- cord-299560-np6nfvf2 51 28 Das Das NNP cord-299560-np6nfvf2 51 29 et et FW cord-299560-np6nfvf2 51 30 al al NNP cord-299560-np6nfvf2 51 31 . . NNP cord-299560-np6nfvf2 51 32 , , , cord-299560-np6nfvf2 51 33 2020 2020 CD cord-299560-np6nfvf2 51 34 ) ) -RRB- cord-299560-np6nfvf2 51 35 . . . cord-299560-np6nfvf2 52 1 Certain certain JJ cord-299560-np6nfvf2 52 2 drugs drug NNS cord-299560-np6nfvf2 52 3 have have VBP cord-299560-np6nfvf2 52 4 several several JJ cord-299560-np6nfvf2 52 5 protein protein NN cord-299560-np6nfvf2 52 6 targets target NNS cord-299560-np6nfvf2 52 7 and and CC cord-299560-np6nfvf2 52 8 many many JJ cord-299560-np6nfvf2 52 9 illnesses illness NNS cord-299560-np6nfvf2 52 10 share share VBP cord-299560-np6nfvf2 52 11 overlapping overlap VBG cord-299560-np6nfvf2 52 12 molecular molecular JJ cord-299560-np6nfvf2 52 13 paths path NNS cord-299560-np6nfvf2 52 14 . . . cord-299560-np6nfvf2 53 1 In in IN cord-299560-np6nfvf2 53 2 such such JJ cord-299560-np6nfvf2 53 3 cases case NNS cord-299560-np6nfvf2 53 4 , , , cord-299560-np6nfvf2 53 5 reusing reuse VBG cord-299560-np6nfvf2 53 6 drugs drug NNS cord-299560-np6nfvf2 53 7 for for IN cord-299560-np6nfvf2 53 8 more more JJR cord-299560-np6nfvf2 53 9 than than IN cord-299560-np6nfvf2 53 10 one one CD cord-299560-np6nfvf2 53 11 objective objective NN cord-299560-np6nfvf2 53 12 and and CC cord-299560-np6nfvf2 53 13 finding find VBG cord-299560-np6nfvf2 53 14 their -PRON- PRP$ cord-299560-np6nfvf2 53 15 novice novice NN cord-299560-np6nfvf2 53 16 uses use NNS cord-299560-np6nfvf2 53 17 can can MD cord-299560-np6nfvf2 53 18 considerably considerably RB cord-299560-np6nfvf2 53 19 decrease decrease VB cord-299560-np6nfvf2 53 20 the the DT cord-299560-np6nfvf2 53 21 time time NN cord-299560-np6nfvf2 53 22 in in IN cord-299560-np6nfvf2 53 23 finding find VBG cord-299560-np6nfvf2 53 24 new new JJ cord-299560-np6nfvf2 53 25 cures cure NNS cord-299560-np6nfvf2 53 26 for for IN cord-299560-np6nfvf2 53 27 unforeseen unforeseen JJ cord-299560-np6nfvf2 53 28 diseases disease NNS cord-299560-np6nfvf2 53 29 ( ( -LRB- cord-299560-np6nfvf2 53 30 Muralidharan Muralidharan NNP cord-299560-np6nfvf2 53 31 et et NNP cord-299560-np6nfvf2 53 32 al al NNP cord-299560-np6nfvf2 53 33 . . NNP cord-299560-np6nfvf2 53 34 , , , cord-299560-np6nfvf2 53 35 2020 2020 CD cord-299560-np6nfvf2 53 36 ) ) -RRB- cord-299560-np6nfvf2 53 37 . . . cord-299560-np6nfvf2 54 1 RDV RDV NNP cord-299560-np6nfvf2 54 2 exhibits exhibit VBZ cord-299560-np6nfvf2 54 3 broad broad JJ cord-299560-np6nfvf2 54 4 - - HYPH cord-299560-np6nfvf2 54 5 spectrum spectrum NN cord-299560-np6nfvf2 54 6 antiviral antiviral JJ cord-299560-np6nfvf2 54 7 activity activity NN cord-299560-np6nfvf2 54 8 against against IN cord-299560-np6nfvf2 54 9 RNA RNA NNP cord-299560-np6nfvf2 54 10 viruses virus NNS cord-299560-np6nfvf2 54 11 , , , cord-299560-np6nfvf2 54 12 and and CC cord-299560-np6nfvf2 54 13 former former JJ cord-299560-np6nfvf2 54 14 studies study NNS cord-299560-np6nfvf2 54 15 with with IN cord-299560-np6nfvf2 54 16 RdRps RdRps NNP cord-299560-np6nfvf2 54 17 from from IN cord-299560-np6nfvf2 54 18 Ebola Ebola NNP cord-299560-np6nfvf2 54 19 virus virus NN cord-299560-np6nfvf2 54 20 ( ( -LRB- cord-299560-np6nfvf2 54 21 EBOV EBOV NNP cord-299560-np6nfvf2 54 22 ) ) -RRB- cord-299560-np6nfvf2 54 23 and and CC cord-299560-np6nfvf2 55 1 Middle Middle NNP cord-299560-np6nfvf2 55 2 East East NNP cord-299560-np6nfvf2 55 3 respiratory respiratory JJ cord-299560-np6nfvf2 55 4 syndrome syndrome NN cord-299560-np6nfvf2 55 5 coronavirus coronavirus NN cord-299560-np6nfvf2 55 6 ( ( -LRB- cord-299560-np6nfvf2 55 7 MERS MERS NNP cord-299560-np6nfvf2 55 8 - - HYPH cord-299560-np6nfvf2 55 9 CoV CoV NNP cord-299560-np6nfvf2 55 10 ) ) -RRB- cord-299560-np6nfvf2 55 11 have have VBP cord-299560-np6nfvf2 55 12 shown show VBN cord-299560-np6nfvf2 55 13 that that IN cord-299560-np6nfvf2 55 14 delayed delay VBN cord-299560-np6nfvf2 55 15 chain chain NN cord-299560-np6nfvf2 55 16 - - HYPH cord-299560-np6nfvf2 55 17 termination termination NN cord-299560-np6nfvf2 55 18 is be VBZ cord-299560-np6nfvf2 55 19 RDV RDV NNP cord-299560-np6nfvf2 55 20 's 's POS cord-299560-np6nfvf2 55 21 conceivable conceivable JJ cord-299560-np6nfvf2 55 22 mechanism mechanism NN cord-299560-np6nfvf2 55 23 of of IN cord-299560-np6nfvf2 55 24 action action NN cord-299560-np6nfvf2 55 25 ( ( -LRB- cord-299560-np6nfvf2 55 26 Figure figure NN cord-299560-np6nfvf2 55 27 2 2 CD cord-299560-np6nfvf2 55 28 ) ) -RRB- cord-299560-np6nfvf2 55 29 ( ( -LRB- cord-299560-np6nfvf2 55 30 Agostini Agostini NNP cord-299560-np6nfvf2 55 31 et et NNP cord-299560-np6nfvf2 55 32 al al NNP cord-299560-np6nfvf2 55 33 . . . cord-299560-np6nfvf2 56 1 , , , cord-299560-np6nfvf2 56 2 2018 2018 CD cord-299560-np6nfvf2 56 3 ; ; : cord-299560-np6nfvf2 56 4 Jordan Jordan NNP cord-299560-np6nfvf2 56 5 et et NNP cord-299560-np6nfvf2 56 6 al al NNP cord-299560-np6nfvf2 56 7 . . NNP cord-299560-np6nfvf2 56 8 , , , cord-299560-np6nfvf2 56 9 2018 2018 CD cord-299560-np6nfvf2 56 10 ; ; : cord-299560-np6nfvf2 56 11 Siegel Siegel NNP cord-299560-np6nfvf2 56 12 et et NNP cord-299560-np6nfvf2 56 13 al al NNP cord-299560-np6nfvf2 56 14 . . . cord-299560-np6nfvf2 57 1 , , , cord-299560-np6nfvf2 57 2 2017 2017 CD cord-299560-np6nfvf2 57 3 ; ; : cord-299560-np6nfvf2 57 4 Tchesnokov Tchesnokov NNP cord-299560-np6nfvf2 57 5 et et NNP cord-299560-np6nfvf2 57 6 al al NNP cord-299560-np6nfvf2 57 7 . . NNP cord-299560-np6nfvf2 57 8 , , , cord-299560-np6nfvf2 57 9 2019 2019 CD cord-299560-np6nfvf2 57 10 ) ) -RRB- cord-299560-np6nfvf2 57 11 . . . cord-299560-np6nfvf2 58 1 Recently recently RB cord-299560-np6nfvf2 58 2 , , , cord-299560-np6nfvf2 58 3 Gordon Gordon NNP cord-299560-np6nfvf2 58 4 , , , cord-299560-np6nfvf2 58 5 Tchesnokov Tchesnokov NNP cord-299560-np6nfvf2 58 6 , , , cord-299560-np6nfvf2 58 7 Woolner Woolner NNP cord-299560-np6nfvf2 58 8 , , , cord-299560-np6nfvf2 58 9 et et NNP cord-299560-np6nfvf2 58 10 al al NNP cord-299560-np6nfvf2 58 11 . . . cord-299560-np6nfvf2 59 1 ( ( -LRB- cord-299560-np6nfvf2 59 2 2020 2020 CD cord-299560-np6nfvf2 59 3 ) ) -RRB- cord-299560-np6nfvf2 59 4 proved prove VBD cord-299560-np6nfvf2 59 5 that that IN cord-299560-np6nfvf2 59 6 RdRp RdRp NNP cord-299560-np6nfvf2 59 7 effectively effectively RB cord-299560-np6nfvf2 59 8 incorporates incorporate VBZ cord-299560-np6nfvf2 59 9 the the DT cord-299560-np6nfvf2 59 10 active active JJ cord-299560-np6nfvf2 59 11 triphosphate triphosphate NN cord-299560-np6nfvf2 59 12 form form NN cord-299560-np6nfvf2 59 13 of of IN cord-299560-np6nfvf2 59 14 RDV RDV NNP cord-299560-np6nfvf2 59 15 ( ( -LRB- cord-299560-np6nfvf2 59 16 RDV RDV NNP cord-299560-np6nfvf2 59 17 - - HYPH cord-299560-np6nfvf2 59 18 TP TP NNP cord-299560-np6nfvf2 59 19 ) ) -RRB- cord-299560-np6nfvf2 59 20 into into IN cord-299560-np6nfvf2 59 21 RNA RNA NNP cord-299560-np6nfvf2 59 22 , , , cord-299560-np6nfvf2 59 23 causing cause VBG cord-299560-np6nfvf2 59 24 termination termination NN cord-299560-np6nfvf2 59 25 of of IN cord-299560-np6nfvf2 59 26 RNA RNA NNP cord-299560-np6nfvf2 59 27 synthesis synthesis NN cord-299560-np6nfvf2 59 28 . . . cord-299560-np6nfvf2 60 1 The the DT cord-299560-np6nfvf2 60 2 investigators investigator NNS cord-299560-np6nfvf2 60 3 obtained obtain VBD cord-299560-np6nfvf2 60 4 almost almost RB cord-299560-np6nfvf2 60 5 identical identical JJ cord-299560-np6nfvf2 60 6 results result NNS cord-299560-np6nfvf2 60 7 with with IN cord-299560-np6nfvf2 60 8 SARS SARS NNP cord-299560-np6nfvf2 60 9 - - HYPH cord-299560-np6nfvf2 60 10 CoV CoV NNP cord-299560-np6nfvf2 60 11 , , , cord-299560-np6nfvf2 60 12 MERS MERS NNP cord-299560-np6nfvf2 60 13 - - HYPH cord-299560-np6nfvf2 60 14 CoV CoV NNP cord-299560-np6nfvf2 60 15 , , , cord-299560-np6nfvf2 60 16 and and CC cord-299560-np6nfvf2 60 17 SARS SARS NNP cord-299560-np6nfvf2 60 18 - - HYPH cord-299560-np6nfvf2 60 19 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 60 20 RdRps RdRps NNP cord-299560-np6nfvf2 60 21 and and CC cord-299560-np6nfvf2 60 22 concluded conclude VBD cord-299560-np6nfvf2 60 23 that that IN cord-299560-np6nfvf2 60 24 the the DT cord-299560-np6nfvf2 60 25 distinguished distinguished JJ cord-299560-np6nfvf2 60 26 property property NN cord-299560-np6nfvf2 60 27 of of IN cord-299560-np6nfvf2 60 28 RDV RDV NNP cord-299560-np6nfvf2 60 29 - - HYPH cord-299560-np6nfvf2 60 30 TP TP NNP cord-299560-np6nfvf2 60 31 is be VBZ cord-299560-np6nfvf2 60 32 its -PRON- PRP$ cord-299560-np6nfvf2 60 33 high high JJ cord-299560-np6nfvf2 60 34 discernment discernment NN cord-299560-np6nfvf2 60 35 over over IN cord-299560-np6nfvf2 60 36 incorporation incorporation NN cord-299560-np6nfvf2 60 37 of of IN cord-299560-np6nfvf2 60 38 its -PRON- PRP$ cord-299560-np6nfvf2 60 39 natural natural JJ cord-299560-np6nfvf2 60 40 nucleotide nucleotide JJ cord-299560-np6nfvf2 60 41 counterpart counterpart NN cord-299560-np6nfvf2 60 42 ATP ATP NNP cord-299560-np6nfvf2 60 43 . . . cord-299560-np6nfvf2 61 1 RDV RDV NNP cord-299560-np6nfvf2 61 2 , , , cord-299560-np6nfvf2 61 3 formerly formerly RB cord-299560-np6nfvf2 61 4 known know VBN cord-299560-np6nfvf2 61 5 as as IN cord-299560-np6nfvf2 61 6 GS-5734 GS-5734 NNS cord-299560-np6nfvf2 61 7 , , , cord-299560-np6nfvf2 61 8 is be VBZ cord-299560-np6nfvf2 61 9 a a DT cord-299560-np6nfvf2 61 10 monophosphoramidate monophosphoramidate JJ cord-299560-np6nfvf2 61 11 prodrug prodrug NN cord-299560-np6nfvf2 61 12 of of IN cord-299560-np6nfvf2 61 13 an an DT cord-299560-np6nfvf2 61 14 adenosine adenosine NN cord-299560-np6nfvf2 61 15 analog analog NN cord-299560-np6nfvf2 61 16 that that WDT cord-299560-np6nfvf2 61 17 was be VBD cord-299560-np6nfvf2 61 18 developed develop VBN cord-299560-np6nfvf2 61 19 in in IN cord-299560-np6nfvf2 61 20 response response NN cord-299560-np6nfvf2 61 21 to to IN cord-299560-np6nfvf2 61 22 the the DT cord-299560-np6nfvf2 61 23 Ebola Ebola NNP cord-299560-np6nfvf2 61 24 outbreak outbreak NN cord-299560-np6nfvf2 61 25 in in IN cord-299560-np6nfvf2 61 26 West West NNP cord-299560-np6nfvf2 61 27 Africa Africa NNP cord-299560-np6nfvf2 61 28 from from IN cord-299560-np6nfvf2 61 29 2014 2014 CD cord-299560-np6nfvf2 61 30 . . . cord-299560-np6nfvf2 62 1 RDV RDV NNP cord-299560-np6nfvf2 62 2 binds bind VBZ cord-299560-np6nfvf2 62 3 to to IN cord-299560-np6nfvf2 62 4 RdRp RdRp NNP cord-299560-np6nfvf2 62 5 and and CC cord-299560-np6nfvf2 62 6 acts act VBZ cord-299560-np6nfvf2 62 7 as as IN cord-299560-np6nfvf2 62 8 RNA RNA NNP cord-299560-np6nfvf2 62 9 chain chain NN cord-299560-np6nfvf2 62 10 terminator terminator NN cord-299560-np6nfvf2 62 11 . . . cord-299560-np6nfvf2 63 1 It -PRON- PRP cord-299560-np6nfvf2 63 2 exhibits exhibit VBZ cord-299560-np6nfvf2 63 3 effective effective JJ cord-299560-np6nfvf2 63 4 in in IN cord-299560-np6nfvf2 63 5 vitro vitro FW cord-299560-np6nfvf2 63 6 activity activity NN cord-299560-np6nfvf2 63 7 against against IN cord-299560-np6nfvf2 63 8 SARS SARS NNP cord-299560-np6nfvf2 63 9 - - HYPH cord-299560-np6nfvf2 63 10 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 63 11 with with IN cord-299560-np6nfvf2 63 12 an an DT cord-299560-np6nfvf2 63 13 EC EC NNP cord-299560-np6nfvf2 63 14 50 50 CD cord-299560-np6nfvf2 63 15 at at IN cord-299560-np6nfvf2 63 16 48 48 CD cord-299560-np6nfvf2 63 17 h h NN cord-299560-np6nfvf2 63 18 of of IN cord-299560-np6nfvf2 63 19 0.77 0.77 CD cord-299560-np6nfvf2 63 20 mM mm CD cord-299560-np6nfvf2 63 21 in in IN cord-299560-np6nfvf2 63 22 Vero Vero NNP cord-299560-np6nfvf2 63 23 E6 E6 NNP cord-299560-np6nfvf2 63 24 cells cell NNS cord-299560-np6nfvf2 63 25 . . . cord-299560-np6nfvf2 64 1 Comparable comparable JJ cord-299560-np6nfvf2 64 2 activity activity NN cord-299560-np6nfvf2 64 3 has have VBZ cord-299560-np6nfvf2 64 4 been be VBN cord-299560-np6nfvf2 64 5 shown show VBN cord-299560-np6nfvf2 64 6 against against IN cord-299560-np6nfvf2 64 7 other other JJ cord-299560-np6nfvf2 64 8 zoonotic zoonotic JJ cord-299560-np6nfvf2 64 9 coronaviruses coronaviruse NNS cord-299560-np6nfvf2 64 10 with with IN cord-299560-np6nfvf2 64 11 EC EC NNP cord-299560-np6nfvf2 64 12 50 50 CD cord-299560-np6nfvf2 64 13 values value NNS cord-299560-np6nfvf2 64 14 of of IN cord-299560-np6nfvf2 64 15 0.07 0.07 CD cord-299560-np6nfvf2 64 16 mM mm CD cord-299560-np6nfvf2 64 17 demonstrated demonstrate VBD cord-299560-np6nfvf2 64 18 for for IN cord-299560-np6nfvf2 64 19 both both DT cord-299560-np6nfvf2 64 20 SARS SARS NNP cord-299560-np6nfvf2 64 21 - - HYPH cord-299560-np6nfvf2 64 22 CoV-1 CoV-1 NNP cord-299560-np6nfvf2 64 23 and and CC cord-299560-np6nfvf2 64 24 MERS MERS NNP cord-299560-np6nfvf2 64 25 - - HYPH cord-299560-np6nfvf2 64 26 CoV cov NN cord-299560-np6nfvf2 64 27 Sheahan Sheahan NNP cord-299560-np6nfvf2 64 28 et et NNP cord-299560-np6nfvf2 64 29 al al NNP cord-299560-np6nfvf2 64 30 . . . cord-299560-np6nfvf2 65 1 , , , cord-299560-np6nfvf2 65 2 2017 2017 CD cord-299560-np6nfvf2 66 1 Sheahan Sheahan NNP cord-299560-np6nfvf2 66 2 et et NNP cord-299560-np6nfvf2 66 3 al al NNP cord-299560-np6nfvf2 66 4 . . . cord-299560-np6nfvf2 67 1 , , , cord-299560-np6nfvf2 67 2 , , , cord-299560-np6nfvf2 67 3 2020 2020 CD cord-299560-np6nfvf2 68 1 Wang Wang NNP cord-299560-np6nfvf2 68 2 et et NNP cord-299560-np6nfvf2 68 3 al al NNP cord-299560-np6nfvf2 68 4 . . NNP cord-299560-np6nfvf2 68 5 , , , cord-299560-np6nfvf2 68 6 2020 2020 CD cord-299560-np6nfvf2 68 7 ) ) -RRB- cord-299560-np6nfvf2 68 8 . . . cord-299560-np6nfvf2 69 1 RDV RDV NNP cord-299560-np6nfvf2 69 2 is be VBZ cord-299560-np6nfvf2 69 3 very very RB cord-299560-np6nfvf2 69 4 discerning discerning JJ cord-299560-np6nfvf2 69 5 for for IN cord-299560-np6nfvf2 69 6 viral viral JJ cord-299560-np6nfvf2 69 7 polymerases polymerase NNS cord-299560-np6nfvf2 69 8 , , , cord-299560-np6nfvf2 69 9 hence hence RB cord-299560-np6nfvf2 69 10 a a DT cord-299560-np6nfvf2 69 11 low low JJ cord-299560-np6nfvf2 69 12 propensity propensity NN cord-299560-np6nfvf2 69 13 to to TO cord-299560-np6nfvf2 69 14 cause cause VB cord-299560-np6nfvf2 69 15 human human JJ cord-299560-np6nfvf2 69 16 toxicity toxicity NN cord-299560-np6nfvf2 69 17 . . . cord-299560-np6nfvf2 70 1 In in IN cord-299560-np6nfvf2 70 2 addition addition NN cord-299560-np6nfvf2 70 3 , , , cord-299560-np6nfvf2 70 4 it -PRON- PRP cord-299560-np6nfvf2 70 5 has have VBZ cord-299560-np6nfvf2 70 6 shown show VBN cord-299560-np6nfvf2 70 7 to to TO cord-299560-np6nfvf2 70 8 have have VB cord-299560-np6nfvf2 70 9 a a DT cord-299560-np6nfvf2 70 10 wide wide JJ cord-299560-np6nfvf2 70 11 therapeutic therapeutic JJ cord-299560-np6nfvf2 70 12 index index NN cord-299560-np6nfvf2 70 13 in in IN cord-299560-np6nfvf2 70 14 a a DT cord-299560-np6nfvf2 70 15 human human JJ cord-299560-np6nfvf2 70 16 airway airway NN cord-299560-np6nfvf2 70 17 epithelial epithelial JJ cord-299560-np6nfvf2 70 18 cell cell NN cord-299560-np6nfvf2 70 19 model model NN cord-299560-np6nfvf2 71 1 ( ( -LRB- cord-299560-np6nfvf2 71 2 Sheahan Sheahan NNP cord-299560-np6nfvf2 71 3 et et NNP cord-299560-np6nfvf2 71 4 al al NNP cord-299560-np6nfvf2 71 5 . . NNP cord-299560-np6nfvf2 71 6 , , , cord-299560-np6nfvf2 71 7 2020 2020 CD cord-299560-np6nfvf2 71 8 ) ) -RRB- cord-299560-np6nfvf2 71 9 . . . cord-299560-np6nfvf2 72 1 The the DT cord-299560-np6nfvf2 72 2 drug drug NN cord-299560-np6nfvf2 72 3 also also RB cord-299560-np6nfvf2 72 4 exhibits exhibit VBZ cord-299560-np6nfvf2 72 5 a a DT cord-299560-np6nfvf2 72 6 high high JJ cord-299560-np6nfvf2 72 7 genetic genetic JJ cord-299560-np6nfvf2 72 8 hurdle hurdle NN cord-299560-np6nfvf2 72 9 to to IN cord-299560-np6nfvf2 72 10 resistance resistance NN cord-299560-np6nfvf2 72 11 in in IN cord-299560-np6nfvf2 72 12 coronaviruses coronaviruse NNS cord-299560-np6nfvf2 72 13 and and CC cord-299560-np6nfvf2 72 14 has have VBZ cord-299560-np6nfvf2 72 15 an an DT cord-299560-np6nfvf2 72 16 extended extend VBN cord-299560-np6nfvf2 72 17 intracellular intracellular JJ cord-299560-np6nfvf2 72 18 half half JJ cord-299560-np6nfvf2 72 19 - - HYPH cord-299560-np6nfvf2 72 20 life life NN cord-299560-np6nfvf2 72 21 that that WDT cord-299560-np6nfvf2 72 22 permits permit VBZ cord-299560-np6nfvf2 72 23 for for IN cord-299560-np6nfvf2 72 24 once once RB cord-299560-np6nfvf2 72 25 - - HYPH cord-299560-np6nfvf2 72 26 daily daily NN cord-299560-np6nfvf2 72 27 dosing dosing NN cord-299560-np6nfvf2 72 28 ( ( -LRB- cord-299560-np6nfvf2 72 29 Agostini Agostini NNP cord-299560-np6nfvf2 72 30 et et NNP cord-299560-np6nfvf2 72 31 al al NNP cord-299560-np6nfvf2 72 32 . . NNP cord-299560-np6nfvf2 72 33 , , , cord-299560-np6nfvf2 72 34 2018 2018 CD cord-299560-np6nfvf2 72 35 ; ; : cord-299560-np6nfvf2 72 36 Sheahan Sheahan NNP cord-299560-np6nfvf2 72 37 et et NNP cord-299560-np6nfvf2 72 38 al al NNP cord-299560-np6nfvf2 72 39 . . NNP cord-299560-np6nfvf2 72 40 , , , cord-299560-np6nfvf2 72 41 2020 2020 CD cord-299560-np6nfvf2 72 42 ) ) -RRB- cord-299560-np6nfvf2 72 43 . . . cord-299560-np6nfvf2 73 1 The the DT cord-299560-np6nfvf2 73 2 safety safety NN cord-299560-np6nfvf2 73 3 and and CC cord-299560-np6nfvf2 73 4 pharmacokinetics pharmacokinetic NNS cord-299560-np6nfvf2 73 5 of of IN cord-299560-np6nfvf2 73 6 RDV RDV NNP cord-299560-np6nfvf2 73 7 were be VBD cord-299560-np6nfvf2 73 8 assessed assess VBN cord-299560-np6nfvf2 73 9 in in IN cord-299560-np6nfvf2 73 10 single single JJ cord-299560-np6nfvf2 73 11 - - HYPH cord-299560-np6nfvf2 73 12 and and CC cord-299560-np6nfvf2 73 13 multiple multiple JJ cord-299560-np6nfvf2 73 14 - - HYPH cord-299560-np6nfvf2 73 15 dose dose NN cord-299560-np6nfvf2 73 16 phase phase NN cord-299560-np6nfvf2 73 17 Intravenous intravenous JJ cord-299560-np6nfvf2 73 18 infusions infusion NNS cord-299560-np6nfvf2 73 19 between between IN cord-299560-np6nfvf2 73 20 3 3 CD cord-299560-np6nfvf2 73 21 mg mg NN cord-299560-np6nfvf2 73 22 and and CC cord-299560-np6nfvf2 73 23 225 225 CD cord-299560-np6nfvf2 73 24 mg mg NNS cord-299560-np6nfvf2 73 25 and and CC cord-299560-np6nfvf2 73 26 were be VBD cord-299560-np6nfvf2 73 27 well well RB cord-299560-np6nfvf2 73 28 - - HYPH cord-299560-np6nfvf2 73 29 tolerated tolerate VBN cord-299560-np6nfvf2 73 30 without without IN cord-299560-np6nfvf2 73 31 any any DT cord-299560-np6nfvf2 73 32 evidence evidence NN cord-299560-np6nfvf2 73 33 of of IN cord-299560-np6nfvf2 73 34 kidney kidney NN cord-299560-np6nfvf2 73 35 or or CC cord-299560-np6nfvf2 73 36 liver liver NN cord-299560-np6nfvf2 73 37 toxicity toxicity NN cord-299560-np6nfvf2 73 38 . . . cord-299560-np6nfvf2 74 1 RDV RDV NNP cord-299560-np6nfvf2 74 2 showed show VBD cord-299560-np6nfvf2 74 3 linear linear JJ cord-299560-np6nfvf2 74 4 pharmacokinetics pharmacokinetic NNS cord-299560-np6nfvf2 74 5 within within IN cord-299560-np6nfvf2 74 6 this this DT cord-299560-np6nfvf2 74 7 dose dose JJ cord-299560-np6nfvf2 74 8 range range NN cord-299560-np6nfvf2 74 9 and and CC cord-299560-np6nfvf2 74 10 an an DT cord-299560-np6nfvf2 74 11 intracellular intracellular JJ cord-299560-np6nfvf2 74 12 half half JJ cord-299560-np6nfvf2 74 13 - - HYPH cord-299560-np6nfvf2 74 14 life life NN cord-299560-np6nfvf2 74 15 of of IN cord-299560-np6nfvf2 74 16 more more JJR cord-299560-np6nfvf2 74 17 than than IN cord-299560-np6nfvf2 74 18 35 35 CD cord-299560-np6nfvf2 74 19 h. h. NN cord-299560-np6nfvf2 74 20 Ensuing ensue VBG cord-299560-np6nfvf2 74 21 multiple multiple JJ cord-299560-np6nfvf2 74 22 - - HYPH cord-299560-np6nfvf2 74 23 dose dose NN cord-299560-np6nfvf2 74 24 infusions infusion NNS cord-299560-np6nfvf2 74 25 , , , cord-299560-np6nfvf2 74 26 reversible reversible JJ cord-299560-np6nfvf2 74 27 aspartate aspartate NN cord-299560-np6nfvf2 74 28 aminotransferase aminotransferase NN cord-299560-np6nfvf2 74 29 and and CC cord-299560-np6nfvf2 74 30 alanine alanine NN cord-299560-np6nfvf2 74 31 transaminase transaminase FW cord-299560-np6nfvf2 74 32 elevations elevation NNS cord-299560-np6nfvf2 74 33 ensued ensue VBD cord-299560-np6nfvf2 74 34 ( ( -LRB- cord-299560-np6nfvf2 74 35 WHO who WP cord-299560-np6nfvf2 74 36 , , , cord-299560-np6nfvf2 74 37 2020b 2020b CD cord-299560-np6nfvf2 74 38 ) ) -RRB- cord-299560-np6nfvf2 74 39 . . . cord-299560-np6nfvf2 75 1 The the DT cord-299560-np6nfvf2 75 2 dose dose NN cord-299560-np6nfvf2 75 3 under under IN cord-299560-np6nfvf2 75 4 investigation investigation NN cord-299560-np6nfvf2 75 5 for for IN cord-299560-np6nfvf2 75 6 treatment treatment NN cord-299560-np6nfvf2 75 7 of of IN cord-299560-np6nfvf2 75 8 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 75 9 is be VBZ cord-299560-np6nfvf2 75 10 200 200 CD cord-299560-np6nfvf2 75 11 mg mg NN cord-299560-np6nfvf2 75 12 intravenously intravenously RB cord-299560-np6nfvf2 75 13 ( ( -LRB- cord-299560-np6nfvf2 75 14 IV IV NNP cord-299560-np6nfvf2 75 15 ) ) -RRB- cord-299560-np6nfvf2 75 16 on on IN cord-299560-np6nfvf2 75 17 day day NN cord-299560-np6nfvf2 75 18 1 1 CD cord-299560-np6nfvf2 75 19 followed follow VBD cord-299560-np6nfvf2 75 20 by by IN cord-299560-np6nfvf2 75 21 100 100 CD cord-299560-np6nfvf2 75 22 mg mg NNP cord-299560-np6nfvf2 75 23 IV IV NNP cord-299560-np6nfvf2 75 24 daily daily RB cord-299560-np6nfvf2 75 25 for for IN cord-299560-np6nfvf2 75 26 up up IN cord-299560-np6nfvf2 75 27 to to TO cord-299560-np6nfvf2 75 28 10 10 CD cord-299560-np6nfvf2 75 29 days day NNS cord-299560-np6nfvf2 75 30 , , , cord-299560-np6nfvf2 75 31 infused infuse VBN cord-299560-np6nfvf2 75 32 over over IN cord-299560-np6nfvf2 75 33 30 30 CD cord-299560-np6nfvf2 75 34 - - SYM cord-299560-np6nfvf2 75 35 60 60 CD cord-299560-np6nfvf2 75 36 min min NN cord-299560-np6nfvf2 75 37 . . . cord-299560-np6nfvf2 76 1 The the DT cord-299560-np6nfvf2 76 2 initial initial JJ cord-299560-np6nfvf2 76 3 clinical clinical JJ cord-299560-np6nfvf2 76 4 use use NN cord-299560-np6nfvf2 76 5 of of IN cord-299560-np6nfvf2 76 6 RDV RDV NNP cord-299560-np6nfvf2 76 7 was be VBD cord-299560-np6nfvf2 76 8 conducted conduct VBN cord-299560-np6nfvf2 76 9 by by IN cord-299560-np6nfvf2 76 10 Jacob Jacob NNP cord-299560-np6nfvf2 76 11 et et NNP cord-299560-np6nfvf2 76 12 al al NNP cord-299560-np6nfvf2 76 13 in in IN cord-299560-np6nfvf2 76 14 2016 2016 CD cord-299560-np6nfvf2 76 15 to to TO cord-299560-np6nfvf2 76 16 treat treat VB cord-299560-np6nfvf2 76 17 Ebola Ebola NNP cord-299560-np6nfvf2 76 18 ( ( -LRB- cord-299560-np6nfvf2 76 19 Jacobs Jacobs NNP cord-299560-np6nfvf2 76 20 et et NNP cord-299560-np6nfvf2 76 21 al al NNP cord-299560-np6nfvf2 76 22 . . NNP cord-299560-np6nfvf2 76 23 , , , cord-299560-np6nfvf2 76 24 2016 2016 CD cord-299560-np6nfvf2 76 25 ) ) -RRB- cord-299560-np6nfvf2 76 26 , , , cord-299560-np6nfvf2 76 27 followed follow VBN cord-299560-np6nfvf2 76 28 by by IN cord-299560-np6nfvf2 76 29 case case NN cord-299560-np6nfvf2 76 30 series series NN cord-299560-np6nfvf2 76 31 ( ( -LRB- cord-299560-np6nfvf2 76 32 Holshue Holshue NNP cord-299560-np6nfvf2 76 33 et et NNP cord-299560-np6nfvf2 76 34 al al NNP cord-299560-np6nfvf2 76 35 . . NNP cord-299560-np6nfvf2 76 36 , , , cord-299560-np6nfvf2 76 37 2020 2020 CD cord-299560-np6nfvf2 76 38 ; ; : cord-299560-np6nfvf2 76 39 Kujawski Kujawski NNP cord-299560-np6nfvf2 76 40 et et NNP cord-299560-np6nfvf2 76 41 al al NNP cord-299560-np6nfvf2 76 42 . . NNP cord-299560-np6nfvf2 76 43 , , , cord-299560-np6nfvf2 76 44 2020 2020 CD cord-299560-np6nfvf2 76 45 ) ) -RRB- cord-299560-np6nfvf2 76 46 . . . cord-299560-np6nfvf2 76 47 _SP cord-299560-np6nfvf2 77 1 As as IN cord-299560-np6nfvf2 77 2 of of IN cord-299560-np6nfvf2 77 3 April April NNP cord-299560-np6nfvf2 77 4 19 19 CD cord-299560-np6nfvf2 77 5 , , , cord-299560-np6nfvf2 77 6 2020 2020 CD cord-299560-np6nfvf2 77 7 , , , cord-299560-np6nfvf2 77 8 the the DT cord-299560-np6nfvf2 77 9 following follow VBG cord-299560-np6nfvf2 77 10 studies study NNS cord-299560-np6nfvf2 77 11 are be VBP cord-299560-np6nfvf2 77 12 being be VBG cord-299560-np6nfvf2 77 13 conducted conduct VBN cord-299560-np6nfvf2 77 14 in in IN cord-299560-np6nfvf2 77 15 the the DT cord-299560-np6nfvf2 77 16 United United NNP cord-299560-np6nfvf2 77 17 States States NNP cord-299560-np6nfvf2 77 18 using use VBG cord-299560-np6nfvf2 77 19 RDV RDV NNP cord-299560-np6nfvf2 77 20 to to TO cord-299560-np6nfvf2 77 21 treat treat VB cord-299560-np6nfvf2 77 22 covid-19 covid-19 NNP cord-299560-np6nfvf2 77 23 ( ( -LRB- cord-299560-np6nfvf2 77 24 ClinicalTrials.gov ClinicalTrials.gov NNP cord-299560-np6nfvf2 77 25 , , , cord-299560-np6nfvf2 77 26 2020 2020 CD cord-299560-np6nfvf2 77 27 ) ) -RRB- cord-299560-np6nfvf2 77 28 : : : cord-299560-np6nfvf2 78 1 NCT04302766 NCT04302766 NNP cord-299560-np6nfvf2 78 2 , , , cord-299560-np6nfvf2 78 3 NCT04292899 NCT04292899 NNP cord-299560-np6nfvf2 78 4 , , , cord-299560-np6nfvf2 78 5 NCT04292730 NCT04292730 NNP cord-299560-np6nfvf2 78 6 , , , cord-299560-np6nfvf2 78 7 NCT04257656 NCT04257656 NNP cord-299560-np6nfvf2 78 8 , , , cord-299560-np6nfvf2 78 9 NCT04252664 NCT04252664 NNP cord-299560-np6nfvf2 78 10 , , , cord-299560-np6nfvf2 78 11 NCT04280705 NCT04280705 NNP cord-299560-np6nfvf2 78 12 . . . cord-299560-np6nfvf2 79 1 In in IN cord-299560-np6nfvf2 79 2 a a DT cord-299560-np6nfvf2 79 3 recent recent JJ cord-299560-np6nfvf2 79 4 study study NN cord-299560-np6nfvf2 79 5 published publish VBN cord-299560-np6nfvf2 79 6 by by IN cord-299560-np6nfvf2 79 7 the the DT cord-299560-np6nfvf2 79 8 New New NNP cord-299560-np6nfvf2 79 9 England England NNP cord-299560-np6nfvf2 79 10 Journal Journal NNP cord-299560-np6nfvf2 79 11 of of IN cord-299560-np6nfvf2 79 12 Medicine Medicine NNP cord-299560-np6nfvf2 79 13 , , , cord-299560-np6nfvf2 79 14 investigators investigator NNS cord-299560-np6nfvf2 79 15 have have VBP cord-299560-np6nfvf2 79 16 used use VBN cord-299560-np6nfvf2 79 17 RDV RDV NNP cord-299560-np6nfvf2 79 18 on on IN cord-299560-np6nfvf2 79 19 a a DT cord-299560-np6nfvf2 79 20 compassionateuse compassionateuse NN cord-299560-np6nfvf2 79 21 basis basis NN cord-299560-np6nfvf2 79 22 to to IN cord-299560-np6nfvf2 79 23 patients patient NNS cord-299560-np6nfvf2 79 24 hospitalized hospitalize VBN cord-299560-np6nfvf2 79 25 with with IN cord-299560-np6nfvf2 79 26 Covid-19 covid-19 NN cord-299560-np6nfvf2 79 27 . . . cord-299560-np6nfvf2 79 28 Participants participant NNS cord-299560-np6nfvf2 79 29 were be VBD cord-299560-np6nfvf2 79 30 patients patient NNS cord-299560-np6nfvf2 79 31 with with IN cord-299560-np6nfvf2 79 32 confirmed confirm VBN cord-299560-np6nfvf2 79 33 SARS SARS NNP cord-299560-np6nfvf2 79 34 - - HYPH cord-299560-np6nfvf2 79 35 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 79 36 infection infection NN cord-299560-np6nfvf2 79 37 and and CC cord-299560-np6nfvf2 79 38 who who WP cord-299560-np6nfvf2 79 39 had have VBD cord-299560-np6nfvf2 79 40 an an DT cord-299560-np6nfvf2 79 41 oxygen oxygen NN cord-299560-np6nfvf2 79 42 saturation saturation NN cord-299560-np6nfvf2 79 43 of of IN cord-299560-np6nfvf2 79 44 94 94 CD cord-299560-np6nfvf2 79 45 % % NN cord-299560-np6nfvf2 79 46 or or CC cord-299560-np6nfvf2 79 47 less less JJR cord-299560-np6nfvf2 79 48 in in IN cord-299560-np6nfvf2 79 49 room room NN cord-299560-np6nfvf2 79 50 air air NN cord-299560-np6nfvf2 79 51 or or CC cord-299560-np6nfvf2 79 52 who who WP cord-299560-np6nfvf2 79 53 were be VBD cord-299560-np6nfvf2 79 54 receiving receive VBG cord-299560-np6nfvf2 79 55 oxygen oxygen NN cord-299560-np6nfvf2 79 56 support support NN cord-299560-np6nfvf2 79 57 . . . cord-299560-np6nfvf2 80 1 Patients patient NNS cord-299560-np6nfvf2 80 2 received receive VBD cord-299560-np6nfvf2 80 3 a a DT cord-299560-np6nfvf2 80 4 10-day 10-day CD cord-299560-np6nfvf2 80 5 course course NN cord-299560-np6nfvf2 80 6 of of IN cord-299560-np6nfvf2 80 7 RDV RDV NNP cord-299560-np6nfvf2 80 8 , , , cord-299560-np6nfvf2 80 9 comprising comprise VBG cord-299560-np6nfvf2 80 10 of of IN cord-299560-np6nfvf2 80 11 200 200 CD cord-299560-np6nfvf2 80 12 mg mg NNS cord-299560-np6nfvf2 80 13 administered administer VBN cord-299560-np6nfvf2 80 14 intravenously intravenously RB cord-299560-np6nfvf2 80 15 on on IN cord-299560-np6nfvf2 80 16 day day NN cord-299560-np6nfvf2 80 17 1 1 CD cord-299560-np6nfvf2 80 18 , , , cord-299560-np6nfvf2 80 19 ensued ensue VBD cord-299560-np6nfvf2 80 20 by by IN cord-299560-np6nfvf2 80 21 100 100 CD cord-299560-np6nfvf2 80 22 mg mg NNP cord-299560-np6nfvf2 80 23 daily daily RB cord-299560-np6nfvf2 80 24 for for IN cord-299560-np6nfvf2 80 25 the the DT cord-299560-np6nfvf2 80 26 remaining remain VBG cord-299560-np6nfvf2 80 27 9 9 CD cord-299560-np6nfvf2 80 28 days day NNS cord-299560-np6nfvf2 80 29 of of IN cord-299560-np6nfvf2 80 30 management management NN cord-299560-np6nfvf2 80 31 . . . cord-299560-np6nfvf2 81 1 Overall overall RB cord-299560-np6nfvf2 81 2 , , , cord-299560-np6nfvf2 81 3 61 61 CD cord-299560-np6nfvf2 81 4 patients patient NNS cord-299560-np6nfvf2 81 5 were be VBD cord-299560-np6nfvf2 81 6 recruited recruit VBN cord-299560-np6nfvf2 81 7 but but CC cord-299560-np6nfvf2 81 8 only only JJ cord-299560-np6nfvf2 81 9 data datum NNS cord-299560-np6nfvf2 81 10 from from IN cord-299560-np6nfvf2 81 11 53 53 CD cord-299560-np6nfvf2 81 12 patients patient NNS cord-299560-np6nfvf2 81 13 were be VBD cord-299560-np6nfvf2 81 14 analyzed analyze VBN cord-299560-np6nfvf2 81 15 . . . cord-299560-np6nfvf2 82 1 Participants participant NNS cord-299560-np6nfvf2 82 2 were be VBD cord-299560-np6nfvf2 82 3 from from IN cord-299560-np6nfvf2 82 4 the the DT cord-299560-np6nfvf2 82 5 United United NNP cord-299560-np6nfvf2 82 6 States States NNP cord-299560-np6nfvf2 82 7 , , , cord-299560-np6nfvf2 82 8 Europe Europe NNP cord-299560-np6nfvf2 82 9 , , , cord-299560-np6nfvf2 82 10 Canada Canada NNP cord-299560-np6nfvf2 82 11 , , , cord-299560-np6nfvf2 82 12 and and CC cord-299560-np6nfvf2 82 13 Japan Japan NNP cord-299560-np6nfvf2 82 14 . . . cord-299560-np6nfvf2 83 1 More More JJR cord-299560-np6nfvf2 83 2 than than IN cord-299560-np6nfvf2 83 3 50 50 CD cord-299560-np6nfvf2 83 4 % % NN cord-299560-np6nfvf2 83 5 of of IN cord-299560-np6nfvf2 83 6 patients patient NNS cord-299560-np6nfvf2 83 7 ( ( -LRB- cord-299560-np6nfvf2 83 8 n n CC cord-299560-np6nfvf2 83 9 ¼ ¼ NNP cord-299560-np6nfvf2 83 10 30 30 CD cord-299560-np6nfvf2 83 11 ) ) -RRB- cord-299560-np6nfvf2 83 12 were be VBD cord-299560-np6nfvf2 83 13 receiving receive VBG cord-299560-np6nfvf2 83 14 mechanical mechanical JJ cord-299560-np6nfvf2 83 15 ventilation ventilation NN cord-299560-np6nfvf2 83 16 and and CC cord-299560-np6nfvf2 83 17 almost almost RB cord-299560-np6nfvf2 83 18 10 10 CD cord-299560-np6nfvf2 83 19 % % NN cord-299560-np6nfvf2 83 20 ( ( -LRB- cord-299560-np6nfvf2 83 21 n n NN cord-299560-np6nfvf2 83 22 ¼ ¼ NNP cord-299560-np6nfvf2 83 23 4 4 CD cord-299560-np6nfvf2 83 24 ) ) -RRB- cord-299560-np6nfvf2 83 25 were be VBD cord-299560-np6nfvf2 83 26 receiving receive VBG cord-299560-np6nfvf2 83 27 extracorporeal extracorporeal JJ cord-299560-np6nfvf2 83 28 membrane membrane NN cord-299560-np6nfvf2 83 29 oxygenation oxygenation NN cord-299560-np6nfvf2 83 30 . . . cord-299560-np6nfvf2 84 1 On on IN cord-299560-np6nfvf2 84 2 follow follow NN cord-299560-np6nfvf2 84 3 - - HYPH cord-299560-np6nfvf2 84 4 up up NN cord-299560-np6nfvf2 84 5 ( ( -LRB- cord-299560-np6nfvf2 84 6 median median JJ cord-299560-np6nfvf2 84 7 ¼18 ¼18 CD cord-299560-np6nfvf2 84 8 days day NNS cord-299560-np6nfvf2 84 9 ) ) -RRB- cord-299560-np6nfvf2 84 10 , , , cord-299560-np6nfvf2 84 11 36 36 CD cord-299560-np6nfvf2 84 12 patients patient NNS cord-299560-np6nfvf2 84 13 ( ( -LRB- cord-299560-np6nfvf2 84 14 68 68 CD cord-299560-np6nfvf2 84 15 % % NN cord-299560-np6nfvf2 84 16 ) ) -RRB- cord-299560-np6nfvf2 84 17 had have VBD cord-299560-np6nfvf2 84 18 an an DT cord-299560-np6nfvf2 84 19 amelioration amelioration NN cord-299560-np6nfvf2 84 20 in in IN cord-299560-np6nfvf2 84 21 oxygen oxygen NN cord-299560-np6nfvf2 84 22 - - HYPH cord-299560-np6nfvf2 84 23 support support NN cord-299560-np6nfvf2 84 24 , , , cord-299560-np6nfvf2 84 25 including include VBG cord-299560-np6nfvf2 84 26 17 17 CD cord-299560-np6nfvf2 84 27 of of IN cord-299560-np6nfvf2 84 28 30 30 CD cord-299560-np6nfvf2 84 29 patients patient NNS cord-299560-np6nfvf2 84 30 ( ( -LRB- cord-299560-np6nfvf2 84 31 57 57 CD cord-299560-np6nfvf2 84 32 % % NN cord-299560-np6nfvf2 84 33 ) ) -RRB- cord-299560-np6nfvf2 84 34 getting get VBG cord-299560-np6nfvf2 84 35 mechanical mechanical JJ cord-299560-np6nfvf2 84 36 ventilation ventilation NN cord-299560-np6nfvf2 84 37 who who WP cord-299560-np6nfvf2 84 38 were be VBD cord-299560-np6nfvf2 84 39 extubated extubate VBN cord-299560-np6nfvf2 84 40 . . . cord-299560-np6nfvf2 85 1 Moreover moreover RB cord-299560-np6nfvf2 85 2 , , , cord-299560-np6nfvf2 85 3 25 25 CD cord-299560-np6nfvf2 85 4 patients patient NNS cord-299560-np6nfvf2 85 5 ( ( -LRB- cord-299560-np6nfvf2 85 6 47 47 CD cord-299560-np6nfvf2 85 7 % % NN cord-299560-np6nfvf2 85 8 ) ) -RRB- cord-299560-np6nfvf2 85 9 were be VBD cord-299560-np6nfvf2 85 10 discharged discharge VBN cord-299560-np6nfvf2 85 11 , , , cord-299560-np6nfvf2 85 12 and and CC cord-299560-np6nfvf2 85 13 7 7 CD cord-299560-np6nfvf2 85 14 patients patient NNS cord-299560-np6nfvf2 85 15 ( ( -LRB- cord-299560-np6nfvf2 85 16 13 13 CD cord-299560-np6nfvf2 85 17 % % NN cord-299560-np6nfvf2 85 18 ) ) -RRB- cord-299560-np6nfvf2 85 19 expired expire VBD cord-299560-np6nfvf2 85 20 . . . cord-299560-np6nfvf2 86 1 The the DT cord-299560-np6nfvf2 86 2 authors author NNS cord-299560-np6nfvf2 86 3 concluded conclude VBD cord-299560-np6nfvf2 86 4 that that IN cord-299560-np6nfvf2 86 5 use use VBP cord-299560-np6nfvf2 86 6 RDV RDV NNP cord-299560-np6nfvf2 86 7 , , , cord-299560-np6nfvf2 86 8 led lead VBN cord-299560-np6nfvf2 86 9 to to IN cord-299560-np6nfvf2 86 10 clinical clinical JJ cord-299560-np6nfvf2 86 11 improvement improvement NN cord-299560-np6nfvf2 86 12 in in IN cord-299560-np6nfvf2 86 13 36 36 CD cord-299560-np6nfvf2 86 14 of of IN cord-299560-np6nfvf2 86 15 53 53 CD cord-299560-np6nfvf2 86 16 patients patient NNS cord-299560-np6nfvf2 86 17 ( ( -LRB- cord-299560-np6nfvf2 86 18 68 68 CD cord-299560-np6nfvf2 86 19 % % NN cord-299560-np6nfvf2 86 20 ) ) -RRB- cord-299560-np6nfvf2 86 21 infected infect VBN cord-299560-np6nfvf2 86 22 with with IN cord-299560-np6nfvf2 86 23 Covid-19 covid-19 NN cord-299560-np6nfvf2 86 24 . . . cord-299560-np6nfvf2 87 1 In in IN cord-299560-np6nfvf2 87 2 terms term NNS cord-299560-np6nfvf2 87 3 of of IN cord-299560-np6nfvf2 87 4 safety safety NN cord-299560-np6nfvf2 87 5 , , , cord-299560-np6nfvf2 87 6 32 32 CD cord-299560-np6nfvf2 87 7 patients patient NNS cord-299560-np6nfvf2 87 8 ( ( -LRB- cord-299560-np6nfvf2 87 9 60 60 CD cord-299560-np6nfvf2 87 10 % % NN cord-299560-np6nfvf2 87 11 ) ) -RRB- cord-299560-np6nfvf2 87 12 reported report VBD cord-299560-np6nfvf2 87 13 adverse adverse JJ cord-299560-np6nfvf2 87 14 events event NNS cord-299560-np6nfvf2 87 15 during during IN cord-299560-np6nfvf2 87 16 follow follow NN cord-299560-np6nfvf2 87 17 - - HYPH cord-299560-np6nfvf2 87 18 up up NN cord-299560-np6nfvf2 87 19 . . . cord-299560-np6nfvf2 88 1 The the DT cord-299560-np6nfvf2 88 2 most most RBS cord-299560-np6nfvf2 88 3 common common JJ cord-299560-np6nfvf2 88 4 side side NN cord-299560-np6nfvf2 88 5 events event NNS cord-299560-np6nfvf2 88 6 were be VBD cord-299560-np6nfvf2 88 7 renal renal JJ cord-299560-np6nfvf2 88 8 impairment impairment NN cord-299560-np6nfvf2 88 9 , , , cord-299560-np6nfvf2 88 10 rash rash JJ cord-299560-np6nfvf2 88 11 , , , cord-299560-np6nfvf2 88 12 diarrhea diarrhea NN cord-299560-np6nfvf2 88 13 , , , cord-299560-np6nfvf2 88 14 increased increase VBN cord-299560-np6nfvf2 88 15 hepatic hepatic JJ cord-299560-np6nfvf2 88 16 enzymes enzyme NNS cord-299560-np6nfvf2 88 17 , , , cord-299560-np6nfvf2 88 18 and and CC cord-299560-np6nfvf2 88 19 hypotension hypotension NN cord-299560-np6nfvf2 88 20 . . . cord-299560-np6nfvf2 89 1 Overall overall RB cord-299560-np6nfvf2 89 2 , , , cord-299560-np6nfvf2 89 3 side side NN cord-299560-np6nfvf2 89 4 effects effect NNS cord-299560-np6nfvf2 89 5 were be VBD cord-299560-np6nfvf2 89 6 more more RBR cord-299560-np6nfvf2 89 7 common common JJ cord-299560-np6nfvf2 89 8 in in IN cord-299560-np6nfvf2 89 9 patients patient NNS cord-299560-np6nfvf2 89 10 on on IN cord-299560-np6nfvf2 89 11 invasive invasive JJ cord-299560-np6nfvf2 89 12 ventilation ventilation NN cord-299560-np6nfvf2 89 13 . . . cord-299560-np6nfvf2 90 1 A a DT cord-299560-np6nfvf2 90 2 total total NN cord-299560-np6nfvf2 90 3 of of IN cord-299560-np6nfvf2 90 4 12 12 CD cord-299560-np6nfvf2 90 5 patients patient NNS cord-299560-np6nfvf2 90 6 ( ( -LRB- cord-299560-np6nfvf2 90 7 23 23 CD cord-299560-np6nfvf2 90 8 % % NN cord-299560-np6nfvf2 90 9 ) ) -RRB- cord-299560-np6nfvf2 90 10 had have VBD cord-299560-np6nfvf2 90 11 grave grave JJ cord-299560-np6nfvf2 90 12 adverse adverse JJ cord-299560-np6nfvf2 90 13 events event NNS cord-299560-np6nfvf2 90 14 , , , cord-299560-np6nfvf2 90 15 most most RBS cord-299560-np6nfvf2 90 16 commonly commonly RB cord-299560-np6nfvf2 90 17 septic septic JJ cord-299560-np6nfvf2 90 18 shock shock NN cord-299560-np6nfvf2 90 19 , , , cord-299560-np6nfvf2 90 20 multiple multiple JJ cord-299560-np6nfvf2 90 21 - - HYPH cord-299560-np6nfvf2 90 22 organ organ NN cord-299560-np6nfvf2 90 23 - - HYPH cord-299560-np6nfvf2 90 24 dysfunction dysfunction NN cord-299560-np6nfvf2 90 25 syndrome syndrome NN cord-299560-np6nfvf2 90 26 , , , cord-299560-np6nfvf2 90 27 hypotension hypotension NN cord-299560-np6nfvf2 90 28 , , , cord-299560-np6nfvf2 90 29 and and CC cord-299560-np6nfvf2 90 30 acute acute JJ cord-299560-np6nfvf2 90 31 kidney kidney NN cord-299560-np6nfvf2 90 32 injury injury NN cord-299560-np6nfvf2 90 33 . . . cord-299560-np6nfvf2 91 1 Four four CD cord-299560-np6nfvf2 91 2 patients patient NNS cord-299560-np6nfvf2 91 3 ( ( -LRB- cord-299560-np6nfvf2 91 4 8 8 CD cord-299560-np6nfvf2 91 5 % % NN cord-299560-np6nfvf2 91 6 ) ) -RRB- cord-299560-np6nfvf2 91 7 terminated terminate VBN cord-299560-np6nfvf2 91 8 RDV RDV NNP cord-299560-np6nfvf2 91 9 treatment treatment NN cord-299560-np6nfvf2 91 10 prematurely prematurely RB cord-299560-np6nfvf2 91 11 : : : cord-299560-np6nfvf2 91 12 one one CD cord-299560-np6nfvf2 91 13 because because IN cord-299560-np6nfvf2 91 14 of of IN cord-299560-np6nfvf2 91 15 deteriorating deteriorate VBG cord-299560-np6nfvf2 91 16 of of IN cord-299560-np6nfvf2 91 17 preexisting preexisting JJ cord-299560-np6nfvf2 91 18 renal renal JJ cord-299560-np6nfvf2 91 19 failure failure NN cord-299560-np6nfvf2 91 20 , , , cord-299560-np6nfvf2 91 21 one one CD cord-299560-np6nfvf2 91 22 because because IN cord-299560-np6nfvf2 91 23 of of IN cord-299560-np6nfvf2 91 24 multiple multiple JJ cord-299560-np6nfvf2 91 25 organ organ NN cord-299560-np6nfvf2 91 26 failure failure NN cord-299560-np6nfvf2 91 27 , , , cord-299560-np6nfvf2 91 28 and and CC cord-299560-np6nfvf2 91 29 two two CD cord-299560-np6nfvf2 91 30 because because IN cord-299560-np6nfvf2 91 31 of of IN cord-299560-np6nfvf2 91 32 transaminitis transaminitis NN cord-299560-np6nfvf2 91 33 , , , cord-299560-np6nfvf2 91 34 including include VBG cord-299560-np6nfvf2 91 35 one one CD cord-299560-np6nfvf2 91 36 patient patient NN cord-299560-np6nfvf2 91 37 with with IN cord-299560-np6nfvf2 91 38 a a DT cord-299560-np6nfvf2 91 39 maculopapular maculopapular JJ cord-299560-np6nfvf2 91 40 rash rash JJ cord-299560-np6nfvf2 92 1 ( ( -LRB- cord-299560-np6nfvf2 92 2 Grein Grein NNP cord-299560-np6nfvf2 92 3 et et NNP cord-299560-np6nfvf2 92 4 al al NNP cord-299560-np6nfvf2 92 5 . . NNP cord-299560-np6nfvf2 92 6 , , , cord-299560-np6nfvf2 92 7 2020 2020 CD cord-299560-np6nfvf2 92 8 ) ) -RRB- cord-299560-np6nfvf2 92 9 . . . cord-299560-np6nfvf2 93 1 On on IN cord-299560-np6nfvf2 93 2 April April NNP cord-299560-np6nfvf2 93 3 29 29 CD cord-299560-np6nfvf2 93 4 , , , cord-299560-np6nfvf2 93 5 2020 2020 CD cord-299560-np6nfvf2 93 6 , , , cord-299560-np6nfvf2 93 7 the the DT cord-299560-np6nfvf2 93 8 National National NNP cord-299560-np6nfvf2 93 9 Institute Institute NNP cord-299560-np6nfvf2 93 10 of of IN cord-299560-np6nfvf2 93 11 Allergy Allergy NNP cord-299560-np6nfvf2 93 12 and and CC cord-299560-np6nfvf2 93 13 Infectious Infectious NNP cord-299560-np6nfvf2 93 14 Diseases Diseases NNPS cord-299560-np6nfvf2 93 15 ( ( -LRB- cord-299560-np6nfvf2 93 16 NIAID NIAID NNP cord-299560-np6nfvf2 93 17 ) ) -RRB- cord-299560-np6nfvf2 93 18 , , , cord-299560-np6nfvf2 93 19 published publish VBD cord-299560-np6nfvf2 93 20 preliminary preliminary JJ cord-299560-np6nfvf2 93 21 results result NNS cord-299560-np6nfvf2 93 22 on on IN cord-299560-np6nfvf2 93 23 the the DT cord-299560-np6nfvf2 93 24 effect effect NN cord-299560-np6nfvf2 93 25 RVD RVD NNP cord-299560-np6nfvf2 93 26 on on IN cord-299560-np6nfvf2 93 27 covid-19 covid-19 NNP cord-299560-np6nfvf2 93 28 illness illness NN cord-299560-np6nfvf2 93 29 . . . cord-299560-np6nfvf2 94 1 The the DT cord-299560-np6nfvf2 94 2 randomized randomized JJ cord-299560-np6nfvf2 94 3 , , , cord-299560-np6nfvf2 94 4 controlled control VBN cord-299560-np6nfvf2 94 5 trial trial NN cord-299560-np6nfvf2 94 6 that that WDT cord-299560-np6nfvf2 94 7 was be VBD cord-299560-np6nfvf2 94 8 initiated initiate VBN cord-299560-np6nfvf2 94 9 on on IN cord-299560-np6nfvf2 94 10 February February NNP cord-299560-np6nfvf2 94 11 21 21 CD cord-299560-np6nfvf2 94 12 , , , cord-299560-np6nfvf2 94 13 2020 2020 CD cord-299560-np6nfvf2 94 14 involved involve VBN cord-299560-np6nfvf2 94 15 1063 1063 CD cord-299560-np6nfvf2 94 16 patients patient NNS cord-299560-np6nfvf2 94 17 . . . cord-299560-np6nfvf2 95 1 The the DT cord-299560-np6nfvf2 95 2 mortality mortality NN cord-299560-np6nfvf2 95 3 rate rate NN cord-299560-np6nfvf2 95 4 for for IN cord-299560-np6nfvf2 95 5 the the DT cord-299560-np6nfvf2 95 6 group group NN cord-299560-np6nfvf2 95 7 of of IN cord-299560-np6nfvf2 95 8 individuals individual NNS cord-299560-np6nfvf2 95 9 who who WP cord-299560-np6nfvf2 95 10 received receive VBD cord-299560-np6nfvf2 95 11 RVD RVD NNP cord-299560-np6nfvf2 95 12 was be VBD cord-299560-np6nfvf2 95 13 8 8 CD cord-299560-np6nfvf2 95 14 % % NN cord-299560-np6nfvf2 95 15 as as IN cord-299560-np6nfvf2 95 16 compared compare VBN cord-299560-np6nfvf2 95 17 to to IN cord-299560-np6nfvf2 95 18 11.6 11.6 CD cord-299560-np6nfvf2 95 19 % % NN cord-299560-np6nfvf2 95 20 in in IN cord-299560-np6nfvf2 95 21 the the DT cord-299560-np6nfvf2 95 22 placebo placebo NN cord-299560-np6nfvf2 95 23 group group NN cord-299560-np6nfvf2 95 24 ( ( -LRB- cord-299560-np6nfvf2 95 25 p p NN cord-299560-np6nfvf2 95 26 ¼ ¼ NNP cord-299560-np6nfvf2 95 27 0.059 0.059 CD cord-299560-np6nfvf2 95 28 ) ) -RRB- cord-299560-np6nfvf2 95 29 . . . cord-299560-np6nfvf2 96 1 For for IN cord-299560-np6nfvf2 96 2 patients patient NNS cord-299560-np6nfvf2 96 3 who who WP cord-299560-np6nfvf2 96 4 survived survive VBD cord-299560-np6nfvf2 96 5 the the DT cord-299560-np6nfvf2 96 6 illness illness NN cord-299560-np6nfvf2 96 7 , , , cord-299560-np6nfvf2 96 8 the the DT cord-299560-np6nfvf2 96 9 median median JJ cord-299560-np6nfvf2 96 10 time time NN cord-299560-np6nfvf2 96 11 to to IN cord-299560-np6nfvf2 96 12 recovery recovery NN cord-299560-np6nfvf2 96 13 was be VBD cord-299560-np6nfvf2 96 14 31 31 CD cord-299560-np6nfvf2 96 15 % % NN cord-299560-np6nfvf2 96 16 quicker quick JJR cord-299560-np6nfvf2 96 17 for for IN cord-299560-np6nfvf2 96 18 patients patient NNS cord-299560-np6nfvf2 96 19 who who WP cord-299560-np6nfvf2 96 20 received receive VBD cord-299560-np6nfvf2 96 21 RVD RVD NNP cord-299560-np6nfvf2 96 22 compared compare VBN cord-299560-np6nfvf2 96 23 with with IN cord-299560-np6nfvf2 96 24 those those DT cord-299560-np6nfvf2 96 25 who who WP cord-299560-np6nfvf2 96 26 received receive VBD cord-299560-np6nfvf2 96 27 placebo placebo NN cord-299560-np6nfvf2 96 28 ( ( -LRB- cord-299560-np6nfvf2 96 29 11 11 CD cord-299560-np6nfvf2 96 30 vs vs IN cord-299560-np6nfvf2 96 31 15 15 CD cord-299560-np6nfvf2 96 32 days day NNS cord-299560-np6nfvf2 96 33 ) ) -RRB- cord-299560-np6nfvf2 97 1 ( ( -LRB- cord-299560-np6nfvf2 97 2 p p NN cord-299560-np6nfvf2 97 3 < < XX cord-299560-np6nfvf2 97 4 0.001 0.001 CD cord-299560-np6nfvf2 97 5 ) ) -RRB- cord-299560-np6nfvf2 98 1 ( ( -LRB- cord-299560-np6nfvf2 98 2 NIH NIH NNP cord-299560-np6nfvf2 98 3 , , , cord-299560-np6nfvf2 98 4 2020 2020 CD cord-299560-np6nfvf2 98 5 ) ) -RRB- cord-299560-np6nfvf2 98 6 . . . cord-299560-np6nfvf2 99 1 On on IN cord-299560-np6nfvf2 99 2 April April NNP cord-299560-np6nfvf2 99 3 29 29 CD cord-299560-np6nfvf2 99 4 , , , cord-299560-np6nfvf2 99 5 2020 2020 CD cord-299560-np6nfvf2 99 6 , , , cord-299560-np6nfvf2 99 7 Gilead Gilead NNP cord-299560-np6nfvf2 99 8 revealed reveal VBD cord-299560-np6nfvf2 99 9 results result NNS cord-299560-np6nfvf2 99 10 from from IN cord-299560-np6nfvf2 99 11 the the DT cord-299560-np6nfvf2 99 12 openlabel openlabel NN cord-299560-np6nfvf2 99 13 , , , cord-299560-np6nfvf2 99 14 Phase phase NN cord-299560-np6nfvf2 99 15 3 3 CD cord-299560-np6nfvf2 99 16 SIMPLE simple JJ cord-299560-np6nfvf2 99 17 trial trial NN cord-299560-np6nfvf2 99 18 evaluating evaluate VBG cord-299560-np6nfvf2 99 19 5-day 5-day JJ cord-299560-np6nfvf2 99 20 and and CC cord-299560-np6nfvf2 99 21 10-day 10-day CD cord-299560-np6nfvf2 99 22 dosing dosing NN cord-299560-np6nfvf2 99 23 durations duration NNS cord-299560-np6nfvf2 99 24 of of IN cord-299560-np6nfvf2 99 25 the the DT cord-299560-np6nfvf2 99 26 investigational investigational JJ cord-299560-np6nfvf2 99 27 antiviral antiviral JJ cord-299560-np6nfvf2 99 28 remdesivir remdesivir NNS cord-299560-np6nfvf2 99 29 in in IN cord-299560-np6nfvf2 99 30 hospitalized hospitalize VBN cord-299560-np6nfvf2 99 31 patients patient NNS cord-299560-np6nfvf2 99 32 with with IN cord-299560-np6nfvf2 99 33 severe severe JJ cord-299560-np6nfvf2 99 34 manifestations manifestation NNS cord-299560-np6nfvf2 99 35 of of IN cord-299560-np6nfvf2 99 36 COVID-19 covid-19 JJ cord-299560-np6nfvf2 99 37 disease disease NN cord-299560-np6nfvf2 99 38 . . . cord-299560-np6nfvf2 100 1 Inclusion inclusion NN cord-299560-np6nfvf2 100 2 criteria criterion NNS cord-299560-np6nfvf2 100 3 was be VBD cord-299560-np6nfvf2 100 4 pneumonia pneumonia NN cord-299560-np6nfvf2 100 5 and and CC cord-299560-np6nfvf2 100 6 reduced reduce VBN cord-299560-np6nfvf2 100 7 oxygen oxygen NN cord-299560-np6nfvf2 100 8 levels level NNS cord-299560-np6nfvf2 100 9 that that WDT cord-299560-np6nfvf2 100 10 did do VBD cord-299560-np6nfvf2 100 11 not not RB cord-299560-np6nfvf2 100 12 require require VB cord-299560-np6nfvf2 100 13 mechanical mechanical JJ cord-299560-np6nfvf2 100 14 ventilation ventilation NN cord-299560-np6nfvf2 100 15 at at IN cord-299560-np6nfvf2 100 16 the the DT cord-299560-np6nfvf2 100 17 time time NN cord-299560-np6nfvf2 100 18 of of IN cord-299560-np6nfvf2 100 19 study study NN cord-299560-np6nfvf2 100 20 . . . cord-299560-np6nfvf2 101 1 The the DT cord-299560-np6nfvf2 101 2 study study NN cord-299560-np6nfvf2 101 3 showed show VBD cord-299560-np6nfvf2 101 4 that that IN cord-299560-np6nfvf2 101 5 patients patient NNS cord-299560-np6nfvf2 101 6 who who WP cord-299560-np6nfvf2 101 7 received receive VBD cord-299560-np6nfvf2 101 8 a a DT cord-299560-np6nfvf2 101 9 10-day 10-day CD cord-299560-np6nfvf2 101 10 treatment treatment NN cord-299560-np6nfvf2 101 11 course course NN cord-299560-np6nfvf2 101 12 of of IN cord-299560-np6nfvf2 101 13 remdesivir remdesivir NNP cord-299560-np6nfvf2 101 14 attained attain VBD cord-299560-np6nfvf2 101 15 comparable comparable JJ cord-299560-np6nfvf2 101 16 improvement improvement NN cord-299560-np6nfvf2 101 17 in in IN cord-299560-np6nfvf2 101 18 clinical clinical JJ cord-299560-np6nfvf2 101 19 status status NN cord-299560-np6nfvf2 101 20 compared compare VBN cord-299560-np6nfvf2 101 21 with with IN cord-299560-np6nfvf2 101 22 those those DT cord-299560-np6nfvf2 101 23 taking take VBG cord-299560-np6nfvf2 101 24 a a DT cord-299560-np6nfvf2 101 25 5-day 5-day JJ cord-299560-np6nfvf2 101 26 treatment treatment NN cord-299560-np6nfvf2 101 27 course course NN cord-299560-np6nfvf2 101 28 ( ( -LRB- cord-299560-np6nfvf2 101 29 Odds Odds NNP cord-299560-np6nfvf2 101 30 Ratio ratio NN cord-299560-np6nfvf2 101 31 : : : cord-299560-np6nfvf2 101 32 0.75 0.75 CD cord-299560-np6nfvf2 101 33 [ [ -LRB- cord-299560-np6nfvf2 101 34 95 95 CD cord-299560-np6nfvf2 101 35 % % NN cord-299560-np6nfvf2 101 36 CI CI NNP cord-299560-np6nfvf2 101 37 0.51 0.51 CD cord-299560-np6nfvf2 101 38 -1.12 -1.12 CD cord-299560-np6nfvf2 101 39 ] ] -RRB- cord-299560-np6nfvf2 101 40 on on IN cord-299560-np6nfvf2 101 41 Day Day NNP cord-299560-np6nfvf2 101 42 14 14 CD cord-299560-np6nfvf2 101 43 ) ) -RRB- cord-299560-np6nfvf2 101 44 . . . cord-299560-np6nfvf2 102 1 The the DT cord-299560-np6nfvf2 102 2 time time NN cord-299560-np6nfvf2 102 3 to to IN cord-299560-np6nfvf2 102 4 clinical clinical JJ cord-299560-np6nfvf2 102 5 improvement improvement NN cord-299560-np6nfvf2 102 6 for for IN cord-299560-np6nfvf2 102 7 50 50 CD cord-299560-np6nfvf2 102 8 percent percent NN cord-299560-np6nfvf2 102 9 of of IN cord-299560-np6nfvf2 102 10 patients patient NNS cord-299560-np6nfvf2 102 11 was be VBD cord-299560-np6nfvf2 102 12 10 10 CD cord-299560-np6nfvf2 102 13 days day NNS cord-299560-np6nfvf2 102 14 in in IN cord-299560-np6nfvf2 102 15 the the DT cord-299560-np6nfvf2 102 16 5-day 5-day JJ cord-299560-np6nfvf2 102 17 treatment treatment NN cord-299560-np6nfvf2 102 18 group group NN cord-299560-np6nfvf2 102 19 and and CC cord-299560-np6nfvf2 102 20 11 11 CD cord-299560-np6nfvf2 102 21 days day NNS cord-299560-np6nfvf2 102 22 in in IN cord-299560-np6nfvf2 102 23 the the DT cord-299560-np6nfvf2 102 24 10-day 10-day CD cord-299560-np6nfvf2 102 25 treatment treatment NN cord-299560-np6nfvf2 102 26 group group NN cord-299560-np6nfvf2 102 27 . . . cord-299560-np6nfvf2 103 1 More More JJR cord-299560-np6nfvf2 103 2 than than IN cord-299560-np6nfvf2 103 3 50 50 CD cord-299560-np6nfvf2 103 4 % % NN cord-299560-np6nfvf2 103 5 of of IN cord-299560-np6nfvf2 103 6 patients patient NNS cord-299560-np6nfvf2 103 7 in in IN cord-299560-np6nfvf2 103 8 both both DT cord-299560-np6nfvf2 103 9 treatment treatment NN cord-299560-np6nfvf2 103 10 groups group NNS cord-299560-np6nfvf2 103 11 were be VBD cord-299560-np6nfvf2 103 12 discharged discharge VBN cord-299560-np6nfvf2 103 13 from from IN cord-299560-np6nfvf2 103 14 the the DT cord-299560-np6nfvf2 103 15 hospital hospital NN cord-299560-np6nfvf2 103 16 by by IN cord-299560-np6nfvf2 103 17 Day Day NNP cord-299560-np6nfvf2 103 18 14 14 CD cord-299560-np6nfvf2 103 19 ( ( -LRB- cord-299560-np6nfvf2 103 20 5-day 5-day NN cord-299560-np6nfvf2 103 21 : : : cord-299560-np6nfvf2 103 22 60.0 60.0 CD cord-299560-np6nfvf2 103 23 % % NN cord-299560-np6nfvf2 103 24 , , , cord-299560-np6nfvf2 103 25 n n NNP cord-299560-np6nfvf2 103 26 ¼ ¼ NNP cord-299560-np6nfvf2 103 27 120/200 120/200 NNP cord-299560-np6nfvf2 104 1 vs.10-day vs.10-day NNP cord-299560-np6nfvf2 104 2 : : : cord-299560-np6nfvf2 104 3 52.3 52.3 CD cord-299560-np6nfvf2 104 4 % % NN cord-299560-np6nfvf2 104 5 n n NN cord-299560-np6nfvf2 104 6 ¼ ¼ NNP cord-299560-np6nfvf2 104 7 103/197 103/197 CD cord-299560-np6nfvf2 104 8 ; ; : cord-299560-np6nfvf2 104 9 p p NN cord-299560-np6nfvf2 104 10 ¼ ¼ CD cord-299560-np6nfvf2 104 11 0.14 0.14 CD cord-299560-np6nfvf2 104 12 ) ) -RRB- cord-299560-np6nfvf2 104 13 . . . cord-299560-np6nfvf2 105 1 At at IN cord-299560-np6nfvf2 105 2 Day day NN cord-299560-np6nfvf2 105 3 14 14 CD cord-299560-np6nfvf2 105 4 , , , cord-299560-np6nfvf2 105 5 64.5 64.5 CD cord-299560-np6nfvf2 105 6 percent percent NN cord-299560-np6nfvf2 105 7 ( ( -LRB- cord-299560-np6nfvf2 105 8 n n NNP cord-299560-np6nfvf2 105 9 ¼ ¼ NNP cord-299560-np6nfvf2 105 10 129/200 129/200 NNP cord-299560-np6nfvf2 105 11 ) ) -RRB- cord-299560-np6nfvf2 105 12 of of IN cord-299560-np6nfvf2 105 13 patients patient NNS cord-299560-np6nfvf2 105 14 in in IN cord-299560-np6nfvf2 105 15 the the DT cord-299560-np6nfvf2 105 16 5-day 5-day JJ cord-299560-np6nfvf2 105 17 treatment treatment NN cord-299560-np6nfvf2 105 18 group group NN cord-299560-np6nfvf2 105 19 and and CC cord-299560-np6nfvf2 105 20 53.8 53.8 CD cord-299560-np6nfvf2 105 21 percent percent NN cord-299560-np6nfvf2 105 22 ( ( -LRB- cord-299560-np6nfvf2 105 23 n n CC cord-299560-np6nfvf2 105 24 ¼ ¼ NNP cord-299560-np6nfvf2 105 25 106/197 106/197 NNP cord-299560-np6nfvf2 105 26 ) ) -RRB- cord-299560-np6nfvf2 105 27 of of IN cord-299560-np6nfvf2 105 28 patients patient NNS cord-299560-np6nfvf2 105 29 in in IN cord-299560-np6nfvf2 105 30 the the DT cord-299560-np6nfvf2 105 31 10-day 10-day CD cord-299560-np6nfvf2 105 32 treatment treatment NN cord-299560-np6nfvf2 105 33 group group NN cord-299560-np6nfvf2 105 34 achieved achieve VBD cord-299560-np6nfvf2 105 35 clinical clinical JJ cord-299560-np6nfvf2 105 36 recovery recovery NN cord-299560-np6nfvf2 105 37 . . . cord-299560-np6nfvf2 106 1 The the DT cord-299560-np6nfvf2 106 2 overall overall JJ cord-299560-np6nfvf2 106 3 mortality mortality NN cord-299560-np6nfvf2 106 4 rate rate NN cord-299560-np6nfvf2 106 5 at at IN cord-299560-np6nfvf2 106 6 Day day NN cord-299560-np6nfvf2 106 7 14 14 CD cord-299560-np6nfvf2 106 8 was be VBD cord-299560-np6nfvf2 106 9 7 7 CD cord-299560-np6nfvf2 106 10 percent percent NN cord-299560-np6nfvf2 106 11 ( ( -LRB- cord-299560-np6nfvf2 106 12 n n NN cord-299560-np6nfvf2 106 13 ¼ ¼ NNP cord-299560-np6nfvf2 106 14 23/320 23/320 CD cord-299560-np6nfvf2 106 15 ) ) -RRB- cord-299560-np6nfvf2 106 16 across across IN cord-299560-np6nfvf2 106 17 both both DT cord-299560-np6nfvf2 106 18 treatment treatment NN cord-299560-np6nfvf2 106 19 groups group NNS cord-299560-np6nfvf2 106 20 , , , cord-299560-np6nfvf2 106 21 with with IN cord-299560-np6nfvf2 106 22 64 64 CD cord-299560-np6nfvf2 106 23 percent percent NN cord-299560-np6nfvf2 106 24 ( ( -LRB- cord-299560-np6nfvf2 106 25 n n NN cord-299560-np6nfvf2 106 26 ¼ ¼ NNP cord-299560-np6nfvf2 106 27 205/320 205/320 NNP cord-299560-np6nfvf2 106 28 ) ) -RRB- cord-299560-np6nfvf2 106 29 of of IN cord-299560-np6nfvf2 106 30 patients patient NNS cord-299560-np6nfvf2 106 31 showing show VBG cord-299560-np6nfvf2 106 32 clinical clinical JJ cord-299560-np6nfvf2 106 33 improvement improvement NN cord-299560-np6nfvf2 106 34 at at IN cord-299560-np6nfvf2 106 35 Day day NN cord-299560-np6nfvf2 106 36 14 14 CD cord-299560-np6nfvf2 106 37 and and CC cord-299560-np6nfvf2 106 38 61 61 CD cord-299560-np6nfvf2 106 39 percent percent NN cord-299560-np6nfvf2 106 40 ( ( -LRB- cord-299560-np6nfvf2 106 41 n n CC cord-299560-np6nfvf2 106 42 ¼ ¼ NNP cord-299560-np6nfvf2 106 43 196/320 196/320 CD cord-299560-np6nfvf2 106 44 ) ) -RRB- cord-299560-np6nfvf2 106 45 of of IN cord-299560-np6nfvf2 106 46 patients patient NNS cord-299560-np6nfvf2 106 47 discharged discharge VBN cord-299560-np6nfvf2 106 48 from from IN cord-299560-np6nfvf2 106 49 the the DT cord-299560-np6nfvf2 106 50 hospital hospital NN cord-299560-np6nfvf2 106 51 . . . cord-299560-np6nfvf2 107 1 No no DT cord-299560-np6nfvf2 107 2 unforeseen unforeseen JJ cord-299560-np6nfvf2 107 3 side side NN cord-299560-np6nfvf2 107 4 effects effect NNS cord-299560-np6nfvf2 107 5 were be VBD cord-299560-np6nfvf2 107 6 detected detect VBN cord-299560-np6nfvf2 107 7 with with IN cord-299560-np6nfvf2 107 8 the the DT cord-299560-np6nfvf2 107 9 use use NN cord-299560-np6nfvf2 107 10 of of IN cord-299560-np6nfvf2 107 11 RDV RDV NNP cord-299560-np6nfvf2 107 12 across across IN cord-299560-np6nfvf2 107 13 either either DT cord-299560-np6nfvf2 107 14 treatment treatment NN cord-299560-np6nfvf2 107 15 group group NN cord-299560-np6nfvf2 107 16 ( ( -LRB- cord-299560-np6nfvf2 107 17 Gilead Gilead NNP cord-299560-np6nfvf2 107 18 , , , cord-299560-np6nfvf2 107 19 2020 2020 CD cord-299560-np6nfvf2 107 20 ) ) -RRB- cord-299560-np6nfvf2 107 21 . . . cord-299560-np6nfvf2 108 1 On on IN cord-299560-np6nfvf2 108 2 May May NNP cord-299560-np6nfvf2 108 3 1 1 CD cord-299560-np6nfvf2 108 4 , , , cord-299560-np6nfvf2 108 5 2020 2020 CD cord-299560-np6nfvf2 108 6 , , , cord-299560-np6nfvf2 108 7 the the DT cord-299560-np6nfvf2 108 8 Food Food NNP cord-299560-np6nfvf2 108 9 and and CC cord-299560-np6nfvf2 108 10 Drug Drug NNP cord-299560-np6nfvf2 108 11 Administration Administration NNP cord-299560-np6nfvf2 108 12 ( ( -LRB- cord-299560-np6nfvf2 108 13 FDA FDA NNP cord-299560-np6nfvf2 108 14 ) ) -RRB- cord-299560-np6nfvf2 108 15 issued issue VBD cord-299560-np6nfvf2 108 16 an an DT cord-299560-np6nfvf2 108 17 Emergency Emergency NNP cord-299560-np6nfvf2 108 18 Use Use NNP cord-299560-np6nfvf2 108 19 Authorization Authorization NNP cord-299560-np6nfvf2 108 20 ( ( -LRB- cord-299560-np6nfvf2 108 21 EUA EUA NNP cord-299560-np6nfvf2 108 22 ) ) -RRB- cord-299560-np6nfvf2 108 23 for for IN cord-299560-np6nfvf2 108 24 emergency emergency NN cord-299560-np6nfvf2 108 25 use use NN cord-299560-np6nfvf2 108 26 of of IN cord-299560-np6nfvf2 108 27 RDV RDV NNP cord-299560-np6nfvf2 108 28 for for IN cord-299560-np6nfvf2 108 29 the the DT cord-299560-np6nfvf2 108 30 treatment treatment NN cord-299560-np6nfvf2 108 31 of of IN cord-299560-np6nfvf2 108 32 hospitalized hospitalize VBN cord-299560-np6nfvf2 108 33 2019 2019 CD cord-299560-np6nfvf2 108 34 coronavirus coronavirus NN cord-299560-np6nfvf2 108 35 disease disease NN cord-299560-np6nfvf2 108 36 ( ( -LRB- cord-299560-np6nfvf2 108 37 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 108 38 ) ) -RRB- cord-299560-np6nfvf2 108 39 patients patient NNS cord-299560-np6nfvf2 108 40 based base VBN cord-299560-np6nfvf2 108 41 on on IN cord-299560-np6nfvf2 108 42 review review NN cord-299560-np6nfvf2 108 43 of of IN cord-299560-np6nfvf2 108 44 the the DT cord-299560-np6nfvf2 108 45 topline topline JJ cord-299560-np6nfvf2 108 46 data datum NNS cord-299560-np6nfvf2 108 47 from from IN cord-299560-np6nfvf2 108 48 the the DT cord-299560-np6nfvf2 108 49 Gilead Gilead NNP cord-299560-np6nfvf2 108 50 - - HYPH cord-299560-np6nfvf2 108 51 sponsored sponsor VBN cord-299560-np6nfvf2 108 52 open open JJ cord-299560-np6nfvf2 108 53 - - HYPH cord-299560-np6nfvf2 108 54 label label NN cord-299560-np6nfvf2 108 55 trial trial NN cord-299560-np6nfvf2 108 56 that that WDT cord-299560-np6nfvf2 108 57 evaluated evaluate VBD cord-299560-np6nfvf2 108 58 different different JJ cord-299560-np6nfvf2 108 59 durations duration NNS cord-299560-np6nfvf2 108 60 of of IN cord-299560-np6nfvf2 108 61 RDV RDV NNP cord-299560-np6nfvf2 108 62 ( ( -LRB- cord-299560-np6nfvf2 108 63 NCT04292899 NCT04292899 NNP cord-299560-np6nfvf2 108 64 ) ) -RRB- cord-299560-np6nfvf2 108 65 , , , cord-299560-np6nfvf2 108 66 and and CC cord-299560-np6nfvf2 108 67 from from IN cord-299560-np6nfvf2 108 68 the the DT cord-299560-np6nfvf2 108 69 randomized randomized JJ cord-299560-np6nfvf2 108 70 , , , cord-299560-np6nfvf2 108 71 double double JJ cord-299560-np6nfvf2 108 72 - - HYPH cord-299560-np6nfvf2 108 73 blinded blinded JJ cord-299560-np6nfvf2 108 74 , , , cord-299560-np6nfvf2 108 75 placebo placebo NN cord-299560-np6nfvf2 108 76 - - HYPH cord-299560-np6nfvf2 108 77 controlled control VBN cord-299560-np6nfvf2 108 78 trial trial NN cord-299560-np6nfvf2 108 79 conducted conduct VBN cord-299560-np6nfvf2 108 80 by by IN cord-299560-np6nfvf2 108 81 NIAID NIAID NNP cord-299560-np6nfvf2 108 82 ( ( -LRB- cord-299560-np6nfvf2 108 83 NCT04280705 NCT04280705 NNP cord-299560-np6nfvf2 108 84 ) ) -RRB- cord-299560-np6nfvf2 108 85 ( ( -LRB- cord-299560-np6nfvf2 108 86 FDA FDA NNP cord-299560-np6nfvf2 108 87 , , , cord-299560-np6nfvf2 108 88 2020 2020 CD cord-299560-np6nfvf2 108 89 ) ) -RRB- cord-299560-np6nfvf2 108 90 . . . cord-299560-np6nfvf2 109 1 Remdesivir Remdesivir NNP cord-299560-np6nfvf2 109 2 might may MD cord-299560-np6nfvf2 109 3 be be VB cord-299560-np6nfvf2 109 4 crucial crucial JJ cord-299560-np6nfvf2 109 5 for for IN cord-299560-np6nfvf2 109 6 ensuring ensure VBG cord-299560-np6nfvf2 109 7 an an DT cord-299560-np6nfvf2 109 8 efficient efficient JJ cord-299560-np6nfvf2 109 9 treatment treatment NN cord-299560-np6nfvf2 109 10 , , , cord-299560-np6nfvf2 109 11 decrease decrease VB cord-299560-np6nfvf2 109 12 mortality mortality NN cord-299560-np6nfvf2 109 13 and and CC cord-299560-np6nfvf2 109 14 allow allow VB cord-299560-np6nfvf2 109 15 early early JJ cord-299560-np6nfvf2 109 16 discharge discharge NN cord-299560-np6nfvf2 109 17 in in IN cord-299560-np6nfvf2 109 18 relation relation NN cord-299560-np6nfvf2 109 19 to to TO cord-299560-np6nfvf2 109 20 Covid-19 covid-19 VB cord-299560-np6nfvf2 109 21 . . . cord-299560-np6nfvf2 110 1 Ongoing ongoing JJ cord-299560-np6nfvf2 110 2 randomized randomized JJ cord-299560-np6nfvf2 110 3 , , , cord-299560-np6nfvf2 110 4 placebo placebo NN cord-299560-np6nfvf2 110 5 - - HYPH cord-299560-np6nfvf2 110 6 controlled control VBN cord-299560-np6nfvf2 110 7 trials trial NNS cord-299560-np6nfvf2 110 8 are be VBP cord-299560-np6nfvf2 110 9 critical critical JJ cord-299560-np6nfvf2 110 10 in in IN cord-299560-np6nfvf2 110 11 delineating delineate VBG cord-299560-np6nfvf2 110 12 its -PRON- PRP$ cord-299560-np6nfvf2 110 13 efficacy efficacy NN cord-299560-np6nfvf2 110 14 . . . cord-299560-np6nfvf2 111 1 In in IN cord-299560-np6nfvf2 111 2 silico silico NN cord-299560-np6nfvf2 111 3 study study VBP cord-299560-np6nfvf2 111 4 the the DT cord-299560-np6nfvf2 111 5 inhibition inhibition NN cord-299560-np6nfvf2 111 6 of of IN cord-299560-np6nfvf2 111 7 Angiotensin Angiotensin NNP cord-299560-np6nfvf2 111 8 converting convert VBG cord-299560-np6nfvf2 111 9 enzyme enzyme NN cord-299560-np6nfvf2 111 10 2 2 CD cord-299560-np6nfvf2 111 11 receptor receptor NN cord-299560-np6nfvf2 111 12 of of IN cord-299560-np6nfvf2 111 13 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 111 14 by by IN cord-299560-np6nfvf2 111 15 Ammoides Ammoides NNP cord-299560-np6nfvf2 111 16 verticillata verticillata VBZ cord-299560-np6nfvf2 111 17 components component NNS cord-299560-np6nfvf2 111 18 harvested harvest VBN cord-299560-np6nfvf2 111 19 from from IN cord-299560-np6nfvf2 111 20 western western JJ cord-299560-np6nfvf2 111 21 Algeria Algeria NNP cord-299560-np6nfvf2 111 22 Coronavirus Coronavirus NNP cord-299560-np6nfvf2 111 23 susceptibility susceptibility NN cord-299560-np6nfvf2 111 24 to to IN cord-299560-np6nfvf2 111 25 the the DT cord-299560-np6nfvf2 111 26 antiviral antiviral JJ cord-299560-np6nfvf2 111 27 remdesivir remdesivir NNS cord-299560-np6nfvf2 111 28 ( ( -LRB- cord-299560-np6nfvf2 111 29 GS-5734 GS-5734 NNP cord-299560-np6nfvf2 111 30 ) ) -RRB- cord-299560-np6nfvf2 111 31 is be VBZ cord-299560-np6nfvf2 111 32 mediated mediate VBN cord-299560-np6nfvf2 111 33 by by IN cord-299560-np6nfvf2 111 34 the the DT cord-299560-np6nfvf2 111 35 viral viral JJ cord-299560-np6nfvf2 111 36 polymerase polymerase NN cord-299560-np6nfvf2 111 37 and and CC cord-299560-np6nfvf2 111 38 the the DT cord-299560-np6nfvf2 111 39 proofreading proofreading NN cord-299560-np6nfvf2 111 40 exoribonuclease exoribonuclease NN cord-299560-np6nfvf2 111 41 Activation Activation NNP cord-299560-np6nfvf2 111 42 of of IN cord-299560-np6nfvf2 111 43 the the DT cord-299560-np6nfvf2 111 44 SARS SARS NNP cord-299560-np6nfvf2 111 45 coronavirus coronavirus NN cord-299560-np6nfvf2 111 46 spike spike NN cord-299560-np6nfvf2 111 47 protein protein NN cord-299560-np6nfvf2 111 48 via via IN cord-299560-np6nfvf2 111 49 sequential sequential JJ cord-299560-np6nfvf2 111 50 proteolytic proteolytic JJ cord-299560-np6nfvf2 111 51 cleavage cleavage NN cord-299560-np6nfvf2 111 52 at at IN cord-299560-np6nfvf2 111 53 two two CD cord-299560-np6nfvf2 111 54 distinct distinct JJ cord-299560-np6nfvf2 111 55 sites site NNS cord-299560-np6nfvf2 111 56 Novel Novel NNP cord-299560-np6nfvf2 111 57 2019 2019 CD cord-299560-np6nfvf2 111 58 coronavirus coronavirus NN cord-299560-np6nfvf2 111 59 structure structure NN cord-299560-np6nfvf2 111 60 , , , cord-299560-np6nfvf2 111 61 mechanism mechanism NN cord-299560-np6nfvf2 111 62 of of IN cord-299560-np6nfvf2 111 63 action action NN cord-299560-np6nfvf2 111 64 , , , cord-299560-np6nfvf2 111 65 antiviral antiviral JJ cord-299560-np6nfvf2 111 66 drug drug NN cord-299560-np6nfvf2 111 67 promises promise NNS cord-299560-np6nfvf2 111 68 and and CC cord-299560-np6nfvf2 111 69 rule rule VB cord-299560-np6nfvf2 111 70 out out RP cord-299560-np6nfvf2 111 71 against against IN cord-299560-np6nfvf2 111 72 its -PRON- PRP$ cord-299560-np6nfvf2 111 73 treatment treatment NN cord-299560-np6nfvf2 111 74 An an DT cord-299560-np6nfvf2 111 75 investigation investigation NN cord-299560-np6nfvf2 111 76 into into IN cord-299560-np6nfvf2 111 77 the the DT cord-299560-np6nfvf2 111 78 identification identification NN cord-299560-np6nfvf2 111 79 of of IN cord-299560-np6nfvf2 111 80 potential potential JJ cord-299560-np6nfvf2 111 81 inhibitors inhibitor NNS cord-299560-np6nfvf2 111 82 of of IN cord-299560-np6nfvf2 111 83 SARS SARS NNP cord-299560-np6nfvf2 111 84 - - HYPH cord-299560-np6nfvf2 111 85 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 111 86 main main JJ cord-299560-np6nfvf2 111 87 protease protease NN cord-299560-np6nfvf2 111 88 using use VBG cord-299560-np6nfvf2 111 89 molecular molecular JJ cord-299560-np6nfvf2 111 90 docking docking NN cord-299560-np6nfvf2 111 91 study study NN cord-299560-np6nfvf2 111 92 Natural natural JJ cord-299560-np6nfvf2 111 93 products product NNS cord-299560-np6nfvf2 111 94 may may MD cord-299560-np6nfvf2 111 95 interfere interfere VB cord-299560-np6nfvf2 111 96 with with IN cord-299560-np6nfvf2 111 97 SARS SARS NNP cord-299560-np6nfvf2 111 98 - - HYPH cord-299560-np6nfvf2 111 99 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 111 100 attachment attachment NN cord-299560-np6nfvf2 111 101 to to IN cord-299560-np6nfvf2 111 102 the the DT cord-299560-np6nfvf2 111 103 host host NN cord-299560-np6nfvf2 111 104 cell cell NN cord-299560-np6nfvf2 111 105 SARS SARS NNP cord-299560-np6nfvf2 111 106 - - HYPH cord-299560-np6nfvf2 111 107 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 112 1 RNA RNA NNP cord-299560-np6nfvf2 112 2 dependent dependent JJ cord-299560-np6nfvf2 112 3 RNA RNA NNP cord-299560-np6nfvf2 112 4 polymerase polymerase NN cord-299560-np6nfvf2 112 5 ( ( -LRB- cord-299560-np6nfvf2 112 6 RdRp RdRp NNP cord-299560-np6nfvf2 112 7 ) ) -RRB- cord-299560-np6nfvf2 112 8 targeting target VBG cord-299560-np6nfvf2 112 9 : : : cord-299560-np6nfvf2 113 1 An an DT cord-299560-np6nfvf2 113 2 in in IN cord-299560-np6nfvf2 113 3 silico silico NN cord-299560-np6nfvf2 113 4 perspective perspective NN cord-299560-np6nfvf2 113 5 Novel Novel NNP cord-299560-np6nfvf2 113 6 guanosine guanosine NN cord-299560-np6nfvf2 113 7 derivatives derivative NNS cord-299560-np6nfvf2 113 8 against against IN cord-299560-np6nfvf2 113 9 MERS MERS NNP cord-299560-np6nfvf2 113 10 CoV CoV NNP cord-299560-np6nfvf2 113 11 polymerase polymerase NNP cord-299560-np6nfvf2 113 12 : : : cord-299560-np6nfvf2 114 1 An an DT cord-299560-np6nfvf2 114 2 in in IN cord-299560-np6nfvf2 114 3 silico silico NN cord-299560-np6nfvf2 114 4 perspective perspective NN cord-299560-np6nfvf2 114 5 Drug drug NN cord-299560-np6nfvf2 114 6 repurposing repurpose VBG cord-299560-np6nfvf2 114 7 for for IN cord-299560-np6nfvf2 114 8 coronavirus coronavirus NN cord-299560-np6nfvf2 114 9 ( ( -LRB- cord-299560-np6nfvf2 114 10 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 114 11 ) ) -RRB- cord-299560-np6nfvf2 114 12 : : : cord-299560-np6nfvf2 115 1 in in IN cord-299560-np6nfvf2 115 2 silico silico NN cord-299560-np6nfvf2 115 3 screening screening NN cord-299560-np6nfvf2 115 4 of of IN cord-299560-np6nfvf2 115 5 known know VBN cord-299560-np6nfvf2 115 6 drugs drug NNS cord-299560-np6nfvf2 115 7 against against IN cord-299560-np6nfvf2 115 8 coronavirus coronavirus NN cord-299560-np6nfvf2 115 9 3CL 3cl CD cord-299560-np6nfvf2 115 10 hydrolase hydrolase NN cord-299560-np6nfvf2 115 11 and and CC cord-299560-np6nfvf2 115 12 protease protease NN cord-299560-np6nfvf2 115 13 enzymes enzyme NNS cord-299560-np6nfvf2 115 14 Reverse reverse VBP cord-299560-np6nfvf2 115 15 vaccinology vaccinology NN cord-299560-np6nfvf2 115 16 approach approach NN cord-299560-np6nfvf2 115 17 to to TO cord-299560-np6nfvf2 115 18 design design VB cord-299560-np6nfvf2 115 19 a a DT cord-299560-np6nfvf2 115 20 novel novel JJ cord-299560-np6nfvf2 115 21 multi multi JJ cord-299560-np6nfvf2 115 22 - - JJ cord-299560-np6nfvf2 115 23 epitope epitope JJ cord-299560-np6nfvf2 115 24 vaccine vaccine NN cord-299560-np6nfvf2 115 25 candidate candidate NN cord-299560-np6nfvf2 115 26 against against IN cord-299560-np6nfvf2 115 27 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 115 28 : : : cord-299560-np6nfvf2 115 29 An an DT cord-299560-np6nfvf2 115 30 in in IN cord-299560-np6nfvf2 115 31 silico silico NN cord-299560-np6nfvf2 115 32 study study NN cord-299560-np6nfvf2 115 33 Andrographolide Andrographolide NNP cord-299560-np6nfvf2 115 34 as as IN cord-299560-np6nfvf2 115 35 a a DT cord-299560-np6nfvf2 115 36 potential potential JJ cord-299560-np6nfvf2 115 37 inhibitor inhibitor NN cord-299560-np6nfvf2 115 38 of of IN cord-299560-np6nfvf2 115 39 SARS SARS NNP cord-299560-np6nfvf2 115 40 - - HYPH cord-299560-np6nfvf2 115 41 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 115 42 main main JJ cord-299560-np6nfvf2 115 43 protease protease NN cord-299560-np6nfvf2 115 44 : : : cord-299560-np6nfvf2 116 1 An an DT cord-299560-np6nfvf2 116 2 in in IN cord-299560-np6nfvf2 116 3 silico silico NN cord-299560-np6nfvf2 116 4 approach approach NN cord-299560-np6nfvf2 117 1 Food Food NNP cord-299560-np6nfvf2 117 2 and and CC cord-299560-np6nfvf2 117 3 Drug Drug NNP cord-299560-np6nfvf2 117 4 Administration Administration NNP cord-299560-np6nfvf2 117 5 ( ( -LRB- cord-299560-np6nfvf2 117 6 FDA FDA NNP cord-299560-np6nfvf2 117 7 ) ) -RRB- cord-299560-np6nfvf2 117 8 Gilead Gilead NNP cord-299560-np6nfvf2 117 9 announces announce VBZ cord-299560-np6nfvf2 117 10 results result NNS cord-299560-np6nfvf2 117 11 from from IN cord-299560-np6nfvf2 117 12 phase phase NN cord-299560-np6nfvf2 117 13 3 3 CD cord-299560-np6nfvf2 117 14 trial trial NN cord-299560-np6nfvf2 117 15 of of IN cord-299560-np6nfvf2 117 16 investigational investigational JJ cord-299560-np6nfvf2 117 17 antiviral antiviral JJ cord-299560-np6nfvf2 117 18 remdesivir remdesivir NNS cord-299560-np6nfvf2 117 19 in in IN cord-299560-np6nfvf2 117 20 patients patient NNS cord-299560-np6nfvf2 117 21 with with IN cord-299560-np6nfvf2 117 22 severe severe JJ cord-299560-np6nfvf2 117 23 COVID-19 covid-19 NN cord-299560-np6nfvf2 117 24 . . . cord-299560-np6nfvf2 118 1 Gilead Gilead NNP cord-299560-np6nfvf2 118 2 Sciences Sciences NNPS cord-299560-np6nfvf2 118 3 Remdesivir Remdesivir NNP cord-299560-np6nfvf2 118 4 is be VBZ cord-299560-np6nfvf2 118 5 a a DT cord-299560-np6nfvf2 118 6 direct direct JJ cord-299560-np6nfvf2 118 7 - - HYPH cord-299560-np6nfvf2 118 8 acting act VBG cord-299560-np6nfvf2 118 9 antiviral antiviral JJ cord-299560-np6nfvf2 118 10 that that WDT cord-299560-np6nfvf2 118 11 inhibits inhibit VBZ cord-299560-np6nfvf2 118 12 RNA rna NN cord-299560-np6nfvf2 118 13 - - HYPH cord-299560-np6nfvf2 118 14 dependent dependent JJ cord-299560-np6nfvf2 118 15 RNA RNA NNP cord-299560-np6nfvf2 118 16 polymerase polymerase NN cord-299560-np6nfvf2 118 17 from from IN cord-299560-np6nfvf2 118 18 severe severe JJ cord-299560-np6nfvf2 118 19 acute acute JJ cord-299560-np6nfvf2 118 20 respiratory respiratory JJ cord-299560-np6nfvf2 118 21 syndrome syndrome NN cord-299560-np6nfvf2 118 22 coronavirus coronavirus NN cord-299560-np6nfvf2 118 23 2 2 CD cord-299560-np6nfvf2 118 24 with with IN cord-299560-np6nfvf2 118 25 high high JJ cord-299560-np6nfvf2 118 26 potency potency NN cord-299560-np6nfvf2 119 1 The the DT cord-299560-np6nfvf2 119 2 antiviral antiviral JJ cord-299560-np6nfvf2 119 3 compound compound NN cord-299560-np6nfvf2 119 4 remdesivir remdesivir NNS cord-299560-np6nfvf2 119 5 potently potently RB cord-299560-np6nfvf2 119 6 inhibits inhibit VBZ cord-299560-np6nfvf2 119 7 RNAdependent RNAdependent NNP cord-299560-np6nfvf2 119 8 RNA RNA NNP cord-299560-np6nfvf2 119 9 polymerase polymerase NN cord-299560-np6nfvf2 119 10 from from IN cord-299560-np6nfvf2 119 11 Middle Middle NNP cord-299560-np6nfvf2 119 12 East East NNP cord-299560-np6nfvf2 119 13 respiratory respiratory JJ cord-299560-np6nfvf2 119 14 syndrome syndrome NN cord-299560-np6nfvf2 119 15 coronavirus coronavirus NN cord-299560-np6nfvf2 119 16 Compassionate compassionate JJ cord-299560-np6nfvf2 119 17 use use NN cord-299560-np6nfvf2 119 18 of of IN cord-299560-np6nfvf2 119 19 remdesivir remdesivir NNS cord-299560-np6nfvf2 119 20 for for IN cord-299560-np6nfvf2 119 21 patients patient NNS cord-299560-np6nfvf2 119 22 with with IN cord-299560-np6nfvf2 119 23 severe severe JJ cord-299560-np6nfvf2 119 24 Covid-19 covid-19 NN cord-299560-np6nfvf2 119 25 In in IN cord-299560-np6nfvf2 119 26 - - HYPH cord-299560-np6nfvf2 119 27 silico silico NN cord-299560-np6nfvf2 119 28 approaches approach NNS cord-299560-np6nfvf2 119 29 to to TO cord-299560-np6nfvf2 119 30 detect detect VB cord-299560-np6nfvf2 119 31 inhibitors inhibitor NNS cord-299560-np6nfvf2 119 32 of of IN cord-299560-np6nfvf2 119 33 the the DT cord-299560-np6nfvf2 119 34 human human JJ cord-299560-np6nfvf2 119 35 severe severe JJ cord-299560-np6nfvf2 119 36 acute acute JJ cord-299560-np6nfvf2 119 37 respiratory respiratory JJ cord-299560-np6nfvf2 119 38 syndrome syndrome NN cord-299560-np6nfvf2 119 39 coronavirus coronavirus NN cord-299560-np6nfvf2 119 40 envelope envelope NN cord-299560-np6nfvf2 119 41 protein protein NN cord-299560-np6nfvf2 119 42 ion ion NN cord-299560-np6nfvf2 119 43 channel channel NN cord-299560-np6nfvf2 120 1 A a DT cord-299560-np6nfvf2 120 2 review review NN cord-299560-np6nfvf2 120 3 on on IN cord-299560-np6nfvf2 120 4 the the DT cord-299560-np6nfvf2 120 5 cleavage cleavage NN cord-299560-np6nfvf2 120 6 priming priming NN cord-299560-np6nfvf2 120 7 of of IN cord-299560-np6nfvf2 120 8 the the DT cord-299560-np6nfvf2 120 9 spike spike NN cord-299560-np6nfvf2 120 10 protein protein NN cord-299560-np6nfvf2 120 11 on on IN cord-299560-np6nfvf2 120 12 coronavirus coronavirus NN cord-299560-np6nfvf2 120 13 by by IN cord-299560-np6nfvf2 120 14 angiotensin angiotensin NN cord-299560-np6nfvf2 120 15 - - HYPH cord-299560-np6nfvf2 120 16 converting convert VBG cord-299560-np6nfvf2 120 17 enzyme-2 enzyme-2 NNP cord-299560-np6nfvf2 120 18 and and CC cord-299560-np6nfvf2 120 19 furin furin NN cord-299560-np6nfvf2 121 1 The the DT cord-299560-np6nfvf2 121 2 novel novel JJ cord-299560-np6nfvf2 121 3 coronavirus coronavirus NN cord-299560-np6nfvf2 121 4 2019 2019 CD cord-299560-np6nfvf2 121 5 ( ( -LRB- cord-299560-np6nfvf2 121 6 2019-nCoV 2019-ncov CD cord-299560-np6nfvf2 121 7 ) ) -RRB- cord-299560-np6nfvf2 121 8 uses use VBZ cord-299560-np6nfvf2 121 9 the the DT cord-299560-np6nfvf2 121 10 SARS SARS NNP cord-299560-np6nfvf2 121 11 - - HYPH cord-299560-np6nfvf2 121 12 coronavirus coronavirus NN cord-299560-np6nfvf2 121 13 receptor receptor NN cord-299560-np6nfvf2 121 14 ACE2 ACE2 NNP cord-299560-np6nfvf2 121 15 and and CC cord-299560-np6nfvf2 121 16 the the DT cord-299560-np6nfvf2 121 17 cellular cellular JJ cord-299560-np6nfvf2 121 18 protease protease NN cord-299560-np6nfvf2 121 19 TMPRSS2 TMPRSS2 NNP cord-299560-np6nfvf2 121 20 for for IN cord-299560-np6nfvf2 121 21 entry entry NN cord-299560-np6nfvf2 121 22 into into IN cord-299560-np6nfvf2 121 23 target target NN cord-299560-np6nfvf2 121 24 cells cell NNS cord-299560-np6nfvf2 122 1 First first JJ cord-299560-np6nfvf2 122 2 case case NN cord-299560-np6nfvf2 122 3 of of IN cord-299560-np6nfvf2 122 4 2019 2019 CD cord-299560-np6nfvf2 122 5 novel novel JJ cord-299560-np6nfvf2 122 6 coronavirus coronavirus NN cord-299560-np6nfvf2 122 7 in in IN cord-299560-np6nfvf2 122 8 the the DT cord-299560-np6nfvf2 122 9 United United NNP cord-299560-np6nfvf2 122 10 States States NNP cord-299560-np6nfvf2 122 11 A a DT cord-299560-np6nfvf2 122 12 molecular molecular JJ cord-299560-np6nfvf2 122 13 modeling modeling NN cord-299560-np6nfvf2 122 14 approach approach NN cord-299560-np6nfvf2 122 15 to to TO cord-299560-np6nfvf2 122 16 identify identify VB cord-299560-np6nfvf2 122 17 effective effective JJ cord-299560-np6nfvf2 122 18 antiviral antiviral JJ cord-299560-np6nfvf2 122 19 phytochemicals phytochemical NNS cord-299560-np6nfvf2 122 20 against against IN cord-299560-np6nfvf2 122 21 the the DT cord-299560-np6nfvf2 122 22 main main JJ cord-299560-np6nfvf2 122 23 protease protease NN cord-299560-np6nfvf2 122 24 of of IN cord-299560-np6nfvf2 122 25 SARS SARS NNP cord-299560-np6nfvf2 122 26 - - HYPH cord-299560-np6nfvf2 122 27 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 123 1 Late late JJ cord-299560-np6nfvf2 123 2 Ebola Ebola NNP cord-299560-np6nfvf2 123 3 virus virus NN cord-299560-np6nfvf2 123 4 relapse relapse NN cord-299560-np6nfvf2 123 5 causing cause VBG cord-299560-np6nfvf2 123 6 meningoencephalitis meningoencephalitis NNP cord-299560-np6nfvf2 123 7 : : : cord-299560-np6nfvf2 123 8 A a DT cord-299560-np6nfvf2 123 9 case case NN cord-299560-np6nfvf2 123 10 report report NN cord-299560-np6nfvf2 123 11 Initiation Initiation NNP cord-299560-np6nfvf2 123 12 , , , cord-299560-np6nfvf2 123 13 extension extension NN cord-299560-np6nfvf2 123 14 , , , cord-299560-np6nfvf2 123 15 and and CC cord-299560-np6nfvf2 123 16 termination termination NN cord-299560-np6nfvf2 123 17 of of IN cord-299560-np6nfvf2 123 18 RNA RNA NNP cord-299560-np6nfvf2 123 19 synthesis synthesis NN cord-299560-np6nfvf2 123 20 by by IN cord-299560-np6nfvf2 123 21 a a DT cord-299560-np6nfvf2 123 22 paramyxovirus paramyxovirus JJ cord-299560-np6nfvf2 123 23 polymerase polymerase NN cord-299560-np6nfvf2 123 24 Discovery Discovery NNP cord-299560-np6nfvf2 123 25 of of IN cord-299560-np6nfvf2 123 26 potential potential JJ cord-299560-np6nfvf2 123 27 multi multi JJ cord-299560-np6nfvf2 123 28 - - JJ cord-299560-np6nfvf2 123 29 target target NN cord-299560-np6nfvf2 123 30 - - HYPH cord-299560-np6nfvf2 123 31 directed direct VBN cord-299560-np6nfvf2 123 32 ligands ligand NNS cord-299560-np6nfvf2 123 33 by by IN cord-299560-np6nfvf2 123 34 targeting target VBG cord-299560-np6nfvf2 123 35 host host NN cord-299560-np6nfvf2 123 36 - - HYPH cord-299560-np6nfvf2 123 37 specific specific JJ cord-299560-np6nfvf2 123 38 SARS SARS NNP cord-299560-np6nfvf2 123 39 - - : cord-299560-np6nfvf2 123 40 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 123 41 structurally structurally RB cord-299560-np6nfvf2 123 42 conserved conserve VBN cord-299560-np6nfvf2 123 43 main main JJ cord-299560-np6nfvf2 123 44 protease$ protease$ NN cord-299560-np6nfvf2 123 45 Identification identification NN cord-299560-np6nfvf2 123 46 of of IN cord-299560-np6nfvf2 123 47 chymotrypsin chymotrypsin JJ cord-299560-np6nfvf2 123 48 - - HYPH cord-299560-np6nfvf2 123 49 like like JJ cord-299560-np6nfvf2 123 50 protease protease NN cord-299560-np6nfvf2 123 51 inhibitors inhibitor NNS cord-299560-np6nfvf2 123 52 of of IN cord-299560-np6nfvf2 123 53 SARS SARS NNP cord-299560-np6nfvf2 123 54 - - HYPH cord-299560-np6nfvf2 123 55 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 123 56 via via IN cord-299560-np6nfvf2 123 57 integrated integrate VBN cord-299560-np6nfvf2 123 58 computational computational JJ cord-299560-np6nfvf2 123 59 approach approach NN cord-299560-np6nfvf2 124 1 Targeting target VBG cord-299560-np6nfvf2 124 2 SARS SARS NNP cord-299560-np6nfvf2 124 3 - - HYPH cord-299560-np6nfvf2 124 4 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 124 5 : : : cord-299560-np6nfvf2 125 1 A a DT cord-299560-np6nfvf2 125 2 systematic systematic JJ cord-299560-np6nfvf2 125 3 drug drug NN cord-299560-np6nfvf2 125 4 repurposing repurposing NN cord-299560-np6nfvf2 125 5 approach approach NN cord-299560-np6nfvf2 125 6 to to TO cord-299560-np6nfvf2 125 7 identify identify VB cord-299560-np6nfvf2 125 8 promising promising JJ cord-299560-np6nfvf2 125 9 inhibitors inhibitor NNS cord-299560-np6nfvf2 125 10 against against IN cord-299560-np6nfvf2 125 11 3C 3c NN cord-299560-np6nfvf2 125 12 - - HYPH cord-299560-np6nfvf2 125 13 like like JJ cord-299560-np6nfvf2 125 14 proteinase proteinase NN cord-299560-np6nfvf2 125 15 and and CC cord-299560-np6nfvf2 125 16 2'-O 2'-o CD cord-299560-np6nfvf2 125 17 - - HYPH cord-299560-np6nfvf2 125 18 ribose ribose NN cord-299560-np6nfvf2 126 1 methyltransferase methyltransferase NNP cord-299560-np6nfvf2 126 2 First first RB cord-299560-np6nfvf2 126 3 12 12 CD cord-299560-np6nfvf2 126 4 patients patient NNS cord-299560-np6nfvf2 126 5 with with IN cord-299560-np6nfvf2 126 6 coronavirus coronavirus NN cord-299560-np6nfvf2 126 7 disease disease NN cord-299560-np6nfvf2 126 8 2019 2019 CD cord-299560-np6nfvf2 126 9 ( ( -LRB- cord-299560-np6nfvf2 126 10 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 126 11 ) ) -RRB- cord-299560-np6nfvf2 126 12 in in IN cord-299560-np6nfvf2 126 13 the the DT cord-299560-np6nfvf2 126 14 United United NNP cord-299560-np6nfvf2 126 15 States States NNP cord-299560-np6nfvf2 126 16 . . . cord-299560-np6nfvf2 127 1 medRxiv medRxiv NNP cord-299560-np6nfvf2 127 2 Computational computational JJ cord-299560-np6nfvf2 127 3 studies study NNS cord-299560-np6nfvf2 127 4 of of IN cord-299560-np6nfvf2 127 5 drug drug NN cord-299560-np6nfvf2 127 6 repurposing repurposing NN cord-299560-np6nfvf2 127 7 and and CC cord-299560-np6nfvf2 127 8 synergism synergism NN cord-299560-np6nfvf2 127 9 of of IN cord-299560-np6nfvf2 127 10 lopinavir lopinavir NNS cord-299560-np6nfvf2 127 11 , , , cord-299560-np6nfvf2 127 12 oseltamivir oseltamivir FW cord-299560-np6nfvf2 127 13 and and CC cord-299560-np6nfvf2 127 14 ritonavir ritonavir NNP cord-299560-np6nfvf2 127 15 binding bind VBG cord-299560-np6nfvf2 127 16 with with IN cord-299560-np6nfvf2 127 17 SARS SARS NNP cord-299560-np6nfvf2 127 18 - - HYPH cord-299560-np6nfvf2 127 19 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 127 20 protease protease NN cord-299560-np6nfvf2 127 21 against against IN cord-299560-np6nfvf2 127 22 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 127 23 Clinical clinical JJ cord-299560-np6nfvf2 127 24 trial trial NN cord-299560-np6nfvf2 127 25 shows show VBZ cord-299560-np6nfvf2 127 26 remdesivir remdesivir NNP cord-299560-np6nfvf2 127 27 accelerates accelerate VBZ cord-299560-np6nfvf2 127 28 recovery recovery NN cord-299560-np6nfvf2 127 29 from from IN cord-299560-np6nfvf2 127 30 advanced advanced JJ cord-299560-np6nfvf2 127 31 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 127 32 Peptide Peptide NNP cord-299560-np6nfvf2 127 33 - - HYPH cord-299560-np6nfvf2 127 34 like like JJ cord-299560-np6nfvf2 127 35 and and CC cord-299560-np6nfvf2 127 36 small small JJ cord-299560-np6nfvf2 127 37 - - HYPH cord-299560-np6nfvf2 127 38 molecule molecule NN cord-299560-np6nfvf2 127 39 inhibitors inhibitor NNS cord-299560-np6nfvf2 127 40 against against IN cord-299560-np6nfvf2 127 41 Covid-19 Covid-19 NNP cord-299560-np6nfvf2 127 42 COVID-2019 COVID-2019 NNP cord-299560-np6nfvf2 128 1 : : : cord-299560-np6nfvf2 128 2 Update update VB cord-299560-np6nfvf2 128 3 on on IN cord-299560-np6nfvf2 128 4 epidemiology epidemiology NN cord-299560-np6nfvf2 128 5 , , , cord-299560-np6nfvf2 128 6 disease disease NN cord-299560-np6nfvf2 128 7 spread spread NN cord-299560-np6nfvf2 128 8 and and CC cord-299560-np6nfvf2 128 9 management management NN cord-299560-np6nfvf2 129 1 In in IN cord-299560-np6nfvf2 129 2 - - HYPH cord-299560-np6nfvf2 129 3 silico silico NN cord-299560-np6nfvf2 129 4 homology homology NN cord-299560-np6nfvf2 129 5 assisted assist VBN cord-299560-np6nfvf2 129 6 identification identification NN cord-299560-np6nfvf2 129 7 of of IN cord-299560-np6nfvf2 129 8 inhibitor inhibitor NN cord-299560-np6nfvf2 129 9 of of IN cord-299560-np6nfvf2 129 10 RNA RNA NNP cord-299560-np6nfvf2 129 11 binding bind VBG cord-299560-np6nfvf2 129 12 against against IN cord-299560-np6nfvf2 129 13 2019-nCoV 2019-ncov CD cord-299560-np6nfvf2 129 14 N n CD cord-299560-np6nfvf2 129 15 - - HYPH cord-299560-np6nfvf2 129 16 protein protein NN cord-299560-np6nfvf2 129 17 ( ( -LRB- cord-299560-np6nfvf2 129 18 N n CD cord-299560-np6nfvf2 129 19 terminal terminal NN cord-299560-np6nfvf2 129 20 domain domain NN cord-299560-np6nfvf2 129 21 ) ) -RRB- cord-299560-np6nfvf2 130 1 Coronavirus Coronavirus NNP cord-299560-np6nfvf2 130 2 envelope envelope NN cord-299560-np6nfvf2 130 3 protein protein NN cord-299560-np6nfvf2 130 4 : : : cord-299560-np6nfvf2 130 5 Current current JJ cord-299560-np6nfvf2 130 6 knowledge knowledge NN cord-299560-np6nfvf2 130 7 Comparative comparative JJ cord-299560-np6nfvf2 130 8 therapeutic therapeutic JJ cord-299560-np6nfvf2 130 9 efficacy efficacy NN cord-299560-np6nfvf2 130 10 of of IN cord-299560-np6nfvf2 130 11 remdesivir remdesivir NNP cord-299560-np6nfvf2 130 12 and and CC cord-299560-np6nfvf2 130 13 combination combination NN cord-299560-np6nfvf2 130 14 lopinavir lopinavir NNS cord-299560-np6nfvf2 130 15 , , , cord-299560-np6nfvf2 130 16 ritonavir ritonavir NNP cord-299560-np6nfvf2 130 17 , , , cord-299560-np6nfvf2 130 18 and and CC cord-299560-np6nfvf2 130 19 interferon interferon NN cord-299560-np6nfvf2 130 20 beta beta NN cord-299560-np6nfvf2 130 21 against against IN cord-299560-np6nfvf2 130 22 MERS MERS NNP cord-299560-np6nfvf2 130 23 - - HYPH cord-299560-np6nfvf2 130 24 CoV CoV NNP cord-299560-np6nfvf2 130 25 Broad Broad NNP cord-299560-np6nfvf2 130 26 - - HYPH cord-299560-np6nfvf2 130 27 spectrum spectrum NN cord-299560-np6nfvf2 130 28 antiviral antiviral JJ cord-299560-np6nfvf2 130 29 GS-5734 GS-5734 NNS cord-299560-np6nfvf2 131 1 inhibits inhibit NNS cord-299560-np6nfvf2 131 2 both both DT cord-299560-np6nfvf2 131 3 epidemic epidemic NN cord-299560-np6nfvf2 131 4 and and CC cord-299560-np6nfvf2 131 5 zoonotic zoonotic JJ cord-299560-np6nfvf2 131 6 coronaviruses coronaviruses NNPS cord-299560-np6nfvf2 131 7 Discovery Discovery NNP cord-299560-np6nfvf2 131 8 and and CC cord-299560-np6nfvf2 131 9 synthesis synthesis NN cord-299560-np6nfvf2 131 10 of of IN cord-299560-np6nfvf2 131 11 a a DT cord-299560-np6nfvf2 131 12 phosphoramidate phosphoramidate JJ cord-299560-np6nfvf2 131 13 prodrug prodrug NN cord-299560-np6nfvf2 131 14 of of IN cord-299560-np6nfvf2 131 15 a a DT cord-299560-np6nfvf2 131 16 pyrrolo[2,1-f][triazin-4-amino pyrrolo[2,1-f][triazin-4-amino JJ cord-299560-np6nfvf2 131 17 ] ] -RRB- cord-299560-np6nfvf2 131 18 adenine adenine NN cord-299560-np6nfvf2 131 19 C c NN cord-299560-np6nfvf2 131 20 - - HYPH cord-299560-np6nfvf2 131 21 nucleoside nucleoside NN cord-299560-np6nfvf2 131 22 ( ( -LRB- cord-299560-np6nfvf2 131 23 GS-5734 GS-5734 NNS cord-299560-np6nfvf2 131 24 ) ) -RRB- cord-299560-np6nfvf2 131 25 for for IN cord-299560-np6nfvf2 131 26 the the DT cord-299560-np6nfvf2 131 27 treatment treatment NN cord-299560-np6nfvf2 131 28 of of IN cord-299560-np6nfvf2 131 29 Ebola Ebola NNP cord-299560-np6nfvf2 131 30 and and CC cord-299560-np6nfvf2 131 31 emerging emerge VBG cord-299560-np6nfvf2 131 32 viruses virus NNS cord-299560-np6nfvf2 132 1 An an DT cord-299560-np6nfvf2 132 2 in in IN cord-299560-np6nfvf2 132 3 - - HYPH cord-299560-np6nfvf2 132 4 silico silico NN cord-299560-np6nfvf2 132 5 evaluation evaluation NN cord-299560-np6nfvf2 132 6 of of IN cord-299560-np6nfvf2 132 7 different different JJ cord-299560-np6nfvf2 132 8 Saikosaponins saikosaponin NNS cord-299560-np6nfvf2 132 9 for for IN cord-299560-np6nfvf2 132 10 their -PRON- PRP$ cord-299560-np6nfvf2 132 11 potency potency NN cord-299560-np6nfvf2 132 12 against against IN cord-299560-np6nfvf2 132 13 SARS SARS NNP cord-299560-np6nfvf2 132 14 - - HYPH cord-299560-np6nfvf2 132 15 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 132 16 using use VBG cord-299560-np6nfvf2 132 17 NSP15 nsp15 NN cord-299560-np6nfvf2 132 18 and and CC cord-299560-np6nfvf2 132 19 fusion fusion NN cord-299560-np6nfvf2 132 20 spike spike NN cord-299560-np6nfvf2 132 21 glycoprotein glycoprotein NN cord-299560-np6nfvf2 132 22 as as IN cord-299560-np6nfvf2 132 23 targets target NNS cord-299560-np6nfvf2 132 24 Mechanism Mechanism NNP cord-299560-np6nfvf2 132 25 of of IN cord-299560-np6nfvf2 132 26 inhibition inhibition NN cord-299560-np6nfvf2 132 27 of of IN cord-299560-np6nfvf2 132 28 Ebola Ebola NNP cord-299560-np6nfvf2 132 29 virus virus NN cord-299560-np6nfvf2 132 30 RNA rna NN cord-299560-np6nfvf2 132 31 - - HYPH cord-299560-np6nfvf2 132 32 dependent dependent JJ cord-299560-np6nfvf2 132 33 RNA RNA NNP cord-299560-np6nfvf2 132 34 polymerase polymerase NN cord-299560-np6nfvf2 132 35 by by IN cord-299560-np6nfvf2 132 36 remdesivir remdesivir NNP cord-299560-np6nfvf2 132 37 Identification Identification NNP cord-299560-np6nfvf2 132 38 of of IN cord-299560-np6nfvf2 132 39 new new JJ cord-299560-np6nfvf2 132 40 anti anti JJ cord-299560-np6nfvf2 132 41 - - JJ cord-299560-np6nfvf2 132 42 nCoV ncov JJ cord-299560-np6nfvf2 132 43 drug drug NN cord-299560-np6nfvf2 132 44 chemical chemical NN cord-299560-np6nfvf2 132 45 compounds compound NNS cord-299560-np6nfvf2 132 46 from from IN cord-299560-np6nfvf2 132 47 Indian indian JJ cord-299560-np6nfvf2 132 48 spices spice NNS cord-299560-np6nfvf2 132 49 exploiting exploit VBG cord-299560-np6nfvf2 132 50 SARS SARS NNP cord-299560-np6nfvf2 132 51 - - HYPH cord-299560-np6nfvf2 132 52 CoV-2 CoV-2 NNP cord-299560-np6nfvf2 132 53 main main JJ cord-299560-np6nfvf2 132 54 protease protease NN cord-299560-np6nfvf2 132 55 as as IN cord-299560-np6nfvf2 132 56 target target NN cord-299560-np6nfvf2 132 57 Stilbene Stilbene NNP cord-299560-np6nfvf2 132 58 - - HYPH cord-299560-np6nfvf2 132 59 based base VBN cord-299560-np6nfvf2 132 60 natural natural JJ cord-299560-np6nfvf2 132 61 compounds compound NNS cord-299560-np6nfvf2 132 62 as as IN cord-299560-np6nfvf2 132 63 promising promising JJ cord-299560-np6nfvf2 132 64 drug drug NN cord-299560-np6nfvf2 132 65 candidates candidate NNS cord-299560-np6nfvf2 132 66 against against IN cord-299560-np6nfvf2 132 67 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 132 68 Remdesivir Remdesivir NNP cord-299560-np6nfvf2 132 69 and and CC cord-299560-np6nfvf2 132 70 chloroquine chloroquine NN cord-299560-np6nfvf2 132 71 effectively effectively RB cord-299560-np6nfvf2 132 72 inhibit inhibit VBP cord-299560-np6nfvf2 132 73 the the DT cord-299560-np6nfvf2 132 74 recently recently RB cord-299560-np6nfvf2 132 75 emerged emerge VBN cord-299560-np6nfvf2 132 76 novel novel JJ cord-299560-np6nfvf2 132 77 coronavirus coronavirus NN cord-299560-np6nfvf2 132 78 ( ( -LRB- cord-299560-np6nfvf2 132 79 2019-nCoV 2019-ncov CD cord-299560-np6nfvf2 132 80 ) ) -RRB- cord-299560-np6nfvf2 132 81 in in IN cord-299560-np6nfvf2 132 82 vitro vitro FW cord-299560-np6nfvf2 132 83 Coronavirus Coronavirus NNP cord-299560-np6nfvf2 132 84 disease disease NN cord-299560-np6nfvf2 132 85 2019 2019 CD cord-299560-np6nfvf2 133 1 ( ( -LRB- cord-299560-np6nfvf2 133 2 COVID-19 COVID-19 NNP cord-299560-np6nfvf2 133 3 ) ) -RRB- cord-299560-np6nfvf2 133 4 Situation Situation NNP cord-299560-np6nfvf2 133 5 Report Report NNP cord-299560-np6nfvf2 133 6 -89 -89 NNP cord-299560-np6nfvf2 133 7 WHO who WP cord-299560-np6nfvf2 133 8 R&D r&d NN cord-299560-np6nfvf2 133 9 blueprint blueprint NN cord-299560-np6nfvf2 133 10 : : : cord-299560-np6nfvf2 134 1 Ad ad NN cord-299560-np6nfvf2 134 2 - - HYPH cord-299560-np6nfvf2 134 3 hoc hoc FW cord-299560-np6nfvf2 134 4 expert expert NN cord-299560-np6nfvf2 134 5 consultation consultation NN cord-299560-np6nfvf2 134 6 on on IN cord-299560-np6nfvf2 134 7 clinical clinical JJ cord-299560-np6nfvf2 134 8 trials trial NNS cord-299560-np6nfvf2 134 9 for for IN cord-299560-np6nfvf2 134 10 Ebola Ebola NNP cord-299560-np6nfvf2 134 11 therapeutics therapeutic NNS cord-299560-np6nfvf2 134 12 Cryo Cryo NNP cord-299560-np6nfvf2 134 13 - - HYPH cord-299560-np6nfvf2 134 14 EM EM NNP cord-299560-np6nfvf2 134 15 structure structure NN cord-299560-np6nfvf2 134 16 of of IN cord-299560-np6nfvf2 134 17 the the DT cord-299560-np6nfvf2 134 18 2019-nCoV 2019-ncov CD cord-299560-np6nfvf2 134 19 spike spike NN cord-299560-np6nfvf2 134 20 in in IN cord-299560-np6nfvf2 134 21 the the DT cord-299560-np6nfvf2 134 22 prefusion prefusion NN cord-299560-np6nfvf2 134 23 conformation conformation NNP cord-299560-np6nfvf2 134 24 Fusion Fusion NNP cord-299560-np6nfvf2 134 25 mechanism mechanism NN cord-299560-np6nfvf2 134 26 of of IN cord-299560-np6nfvf2 134 27 2019-nCoV 2019-ncov CD cord-299560-np6nfvf2 134 28 and and CC cord-299560-np6nfvf2 134 29 fusion fusion NN cord-299560-np6nfvf2 134 30 inhibitors inhibitor NNS cord-299560-np6nfvf2 134 31 targeting target VBG cord-299560-np6nfvf2 134 32 HR1 HR1 NNP cord-299560-np6nfvf2 134 33 domain domain NN cord-299560-np6nfvf2 134 34 in in IN cord-299560-np6nfvf2 134 35 spike spike NN cord-299560-np6nfvf2 134 36 protein protein NN cord-299560-np6nfvf2 135 1 A a DT cord-299560-np6nfvf2 135 2 novel novel JJ cord-299560-np6nfvf2 135 3 coronavirus coronavirus NN cord-299560-np6nfvf2 135 4 from from IN cord-299560-np6nfvf2 135 5 patients patient NNS cord-299560-np6nfvf2 135 6 with with IN cord-299560-np6nfvf2 135 7 pneumonia pneumonia NN cord-299560-np6nfvf2 135 8 in in IN cord-299560-np6nfvf2 135 9 China China NNP cord-299560-np6nfvf2 135 10 Special special JJ cord-299560-np6nfvf2 135 11 appreciation appreciation NN cord-299560-np6nfvf2 135 12 for for IN cord-299560-np6nfvf2 135 13 architect architect NN cord-299560-np6nfvf2 135 14 Riad Riad NNP cord-299560-np6nfvf2 135 15 Younes Younes NNP cord-299560-np6nfvf2 135 16 for for IN cord-299560-np6nfvf2 135 17 developing develop VBG cord-299560-np6nfvf2 135 18 the the DT cord-299560-np6nfvf2 135 19 figures figure NNS cord-299560-np6nfvf2 135 20 . . . cord-299560-np6nfvf2 136 1 The the DT cord-299560-np6nfvf2 136 2 authors author NNS cord-299560-np6nfvf2 136 3 have have VBP cord-299560-np6nfvf2 136 4 no no DT cord-299560-np6nfvf2 136 5 potential potential JJ cord-299560-np6nfvf2 136 6 conflicts conflict NNS cord-299560-np6nfvf2 136 7 of of IN cord-299560-np6nfvf2 136 8 interest interest NN cord-299560-np6nfvf2 136 9 relevant relevant JJ cord-299560-np6nfvf2 136 10 to to IN cord-299560-np6nfvf2 136 11 this this DT cord-299560-np6nfvf2 136 12 article article NN cord-299560-np6nfvf2 136 13 to to TO cord-299560-np6nfvf2 136 14 disclose disclose VB cord-299560-np6nfvf2 136 15 . . . cord-299560-np6nfvf2 137 1 The the DT cord-299560-np6nfvf2 137 2 authors author NNS cord-299560-np6nfvf2 137 3 have have VBP cord-299560-np6nfvf2 137 4 no no DT cord-299560-np6nfvf2 137 5 financial financial JJ cord-299560-np6nfvf2 137 6 relationships relationship NNS cord-299560-np6nfvf2 137 7 relevant relevant JJ cord-299560-np6nfvf2 137 8 to to IN cord-299560-np6nfvf2 137 9 this this DT cord-299560-np6nfvf2 137 10 article article NN cord-299560-np6nfvf2 137 11 to to TO cord-299560-np6nfvf2 137 12 disclose disclose VB cord-299560-np6nfvf2 137 13 . . .