id	sid	tid	token	lemma	pos
cord-290218-dvyeg5fk	1	1	key	key	NN
cord-290218-dvyeg5fk	1	2	:	:	:
cord-290218-dvyeg5fk	2	1	cord-290218-dvyeg5fk	cord-290218-dvyeg5fk	VBN
cord-290218-dvyeg5fk	3	1	authors	author	NNS
cord-290218-dvyeg5fk	3	2	:	:	:
cord-290218-dvyeg5fk	3	3	Jiang	Jiang	NNP
cord-290218-dvyeg5fk	3	4	,	,	,
cord-290218-dvyeg5fk	3	5	Yi	Yi	NNP
cord-290218-dvyeg5fk	3	6	;	;	:
cord-290218-dvyeg5fk	3	7	Yin	Yin	NNP
cord-290218-dvyeg5fk	3	8	,	,	,
cord-290218-dvyeg5fk	3	9	Wanchao	Wanchao	NNP
cord-290218-dvyeg5fk	3	10	;	;	,
cord-290218-dvyeg5fk	3	11	Xu	Xu	NNP
cord-290218-dvyeg5fk	3	12	,	,	,
cord-290218-dvyeg5fk	3	13	H.	H.	NNP
cord-290218-dvyeg5fk	3	14	Eric	Eric	NNP
cord-290218-dvyeg5fk	3	15	title	title	NN
cord-290218-dvyeg5fk	3	16	:	:	:
cord-290218-dvyeg5fk	3	17	RNA	rna	NN
cord-290218-dvyeg5fk	3	18	-	-	HYPH
cord-290218-dvyeg5fk	3	19	dependent	dependent	JJ
cord-290218-dvyeg5fk	3	20	RNA	RNA	NNP
cord-290218-dvyeg5fk	3	21	polymerase	polymerase	NN
cord-290218-dvyeg5fk	3	22	:	:	:
cord-290218-dvyeg5fk	3	23	Structure	structure	NN
cord-290218-dvyeg5fk	3	24	,	,	,
cord-290218-dvyeg5fk	3	25	mechanism	mechanism	NN
cord-290218-dvyeg5fk	3	26	,	,	,
cord-290218-dvyeg5fk	3	27	and	and	CC
cord-290218-dvyeg5fk	3	28	drug	drug	NN
cord-290218-dvyeg5fk	3	29	discovery	discovery	NN
cord-290218-dvyeg5fk	3	30	for	for	IN
cord-290218-dvyeg5fk	3	31	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	3	32	date	date	NN
cord-290218-dvyeg5fk	3	33	:	:	:
cord-290218-dvyeg5fk	3	34	2020	2020	CD
cord-290218-dvyeg5fk	3	35	-	-	HYPH
cord-290218-dvyeg5fk	3	36	09	09	CD
cord-290218-dvyeg5fk	3	37	-	-	HYPH
cord-290218-dvyeg5fk	3	38	04	04	CD
cord-290218-dvyeg5fk	3	39	journal	journal	NN
cord-290218-dvyeg5fk	3	40	:	:	:
cord-290218-dvyeg5fk	3	41	Biochem	Biochem	NNP
cord-290218-dvyeg5fk	3	42	Biophys	Biophys	NNP
cord-290218-dvyeg5fk	3	43	Res	Res	HYPH
cord-290218-dvyeg5fk	3	44	Commun	commun	NN
cord-290218-dvyeg5fk	3	45	DOI	doi	NN
cord-290218-dvyeg5fk	3	46	:	:	:
cord-290218-dvyeg5fk	3	47	10.1016/	10.1016/	CD
cord-290218-dvyeg5fk	4	1	j.bbrc.2020.08.116	j.bbrc.2020.08.116	NNP
cord-290218-dvyeg5fk	4	2	sha	sha	XX
cord-290218-dvyeg5fk	4	3	:	:	:
cord-290218-dvyeg5fk	5	1	e9996bcc14b0cdf1da458165de69a67eaa1736b6	e9996bcc14b0cdf1da458165de69a67eaa1736b6	RB
cord-290218-dvyeg5fk	6	1	doc_id	doc_id	CD
cord-290218-dvyeg5fk	6	2	:	:	:
cord-290218-dvyeg5fk	7	1	290218	290218	CD
cord-290218-dvyeg5fk	7	2	cord_uid	cord_uid	NNS
cord-290218-dvyeg5fk	7	3	:	:	:
cord-290218-dvyeg5fk	8	1	dvyeg5fk	dvyeg5fk	IN
cord-290218-dvyeg5fk	8	2	Coronavirus	Coronavirus	NNP
cord-290218-dvyeg5fk	8	3	disease	disease	NN
cord-290218-dvyeg5fk	8	4	2019	2019	CD
cord-290218-dvyeg5fk	8	5	(	(	-LRB-
cord-290218-dvyeg5fk	8	6	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	8	7	)	)	-RRB-
cord-290218-dvyeg5fk	8	8	caused	cause	VBN
cord-290218-dvyeg5fk	8	9	by	by	IN
cord-290218-dvyeg5fk	8	10	severe	severe	JJ
cord-290218-dvyeg5fk	8	11	acute	acute	JJ
cord-290218-dvyeg5fk	8	12	respiratory	respiratory	JJ
cord-290218-dvyeg5fk	8	13	syndrome	syndrome	NN
cord-290218-dvyeg5fk	8	14	coronavirus-2	coronavirus-2	NN
cord-290218-dvyeg5fk	9	1	(	(	-LRB-
cord-290218-dvyeg5fk	9	2	SARS	SARS	NNP
cord-290218-dvyeg5fk	9	3	-	-	HYPH
cord-290218-dvyeg5fk	9	4	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	9	5	)	)	-RRB-
cord-290218-dvyeg5fk	9	6	has	have	VBZ
cord-290218-dvyeg5fk	9	7	rapidly	rapidly	RB
cord-290218-dvyeg5fk	9	8	become	become	VBN
cord-290218-dvyeg5fk	9	9	a	a	DT
cord-290218-dvyeg5fk	9	10	global	global	JJ
cord-290218-dvyeg5fk	9	11	pandemic	pandemic	NN
cord-290218-dvyeg5fk	9	12	.	.	.
cord-290218-dvyeg5fk	10	1	Although	although	IN
cord-290218-dvyeg5fk	10	2	great	great	JJ
cord-290218-dvyeg5fk	10	3	efforts	effort	NNS
cord-290218-dvyeg5fk	10	4	have	have	VBP
cord-290218-dvyeg5fk	10	5	been	be	VBN
cord-290218-dvyeg5fk	10	6	made	make	VBN
cord-290218-dvyeg5fk	10	7	to	to	TO
cord-290218-dvyeg5fk	10	8	develop	develop	VB
cord-290218-dvyeg5fk	10	9	effective	effective	JJ
cord-290218-dvyeg5fk	10	10	therapeutic	therapeutic	JJ
cord-290218-dvyeg5fk	10	11	interventions	intervention	NNS
cord-290218-dvyeg5fk	10	12	,	,	,
cord-290218-dvyeg5fk	10	13	only	only	RB
cord-290218-dvyeg5fk	10	14	the	the	DT
cord-290218-dvyeg5fk	10	15	nucleotide	nucleotide	JJ
cord-290218-dvyeg5fk	10	16	analog	analog	NN
cord-290218-dvyeg5fk	10	17	remdesivir	remdesivir	NNP
cord-290218-dvyeg5fk	10	18	was	be	VBD
cord-290218-dvyeg5fk	10	19	approved	approve	VBN
cord-290218-dvyeg5fk	10	20	for	for	IN
cord-290218-dvyeg5fk	10	21	emergency	emergency	NN
cord-290218-dvyeg5fk	10	22	use	use	NN
cord-290218-dvyeg5fk	10	23	against	against	IN
cord-290218-dvyeg5fk	10	24	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	10	25	.	.	.
cord-290218-dvyeg5fk	11	1	Remdesivir	Remdesivir	NNP
cord-290218-dvyeg5fk	11	2	targets	target	VBZ
cord-290218-dvyeg5fk	11	3	the	the	DT
cord-290218-dvyeg5fk	11	4	RNA	RNA	NNP
cord-290218-dvyeg5fk	11	5	-	-	HYPH
cord-290218-dvyeg5fk	11	6	dependent	dependent	JJ
cord-290218-dvyeg5fk	11	7	RNA	RNA	NNP
cord-290218-dvyeg5fk	11	8	polymerase	polymerase	NN
cord-290218-dvyeg5fk	11	9	(	(	-LRB-
cord-290218-dvyeg5fk	11	10	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	11	11	)	)	-RRB-
cord-290218-dvyeg5fk	11	12	,	,	,
cord-290218-dvyeg5fk	11	13	an	an	DT
cord-290218-dvyeg5fk	11	14	essential	essential	JJ
cord-290218-dvyeg5fk	11	15	enzyme	enzyme	NN
cord-290218-dvyeg5fk	11	16	for	for	IN
cord-290218-dvyeg5fk	11	17	viral	viral	JJ
cord-290218-dvyeg5fk	11	18	RNA	RNA	NNP
cord-290218-dvyeg5fk	11	19	replication	replication	NN
cord-290218-dvyeg5fk	11	20	and	and	CC
cord-290218-dvyeg5fk	11	21	a	a	DT
cord-290218-dvyeg5fk	11	22	promising	promising	JJ
cord-290218-dvyeg5fk	11	23	drug	drug	NN
cord-290218-dvyeg5fk	11	24	target	target	NN
cord-290218-dvyeg5fk	11	25	for	for	IN
cord-290218-dvyeg5fk	11	26	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	11	27	.	.	.
cord-290218-dvyeg5fk	12	1	Recently	recently	RB
cord-290218-dvyeg5fk	12	2	,	,	,
cord-290218-dvyeg5fk	12	3	several	several	JJ
cord-290218-dvyeg5fk	12	4	structures	structure	NNS
cord-290218-dvyeg5fk	12	5	of	of	IN
cord-290218-dvyeg5fk	12	6	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	12	7	in	in	IN
cord-290218-dvyeg5fk	12	8	complex	complex	NN
cord-290218-dvyeg5fk	12	9	with	with	IN
cord-290218-dvyeg5fk	12	10	substrate	substrate	JJ
cord-290218-dvyeg5fk	12	11	RNA	RNA	NNP
cord-290218-dvyeg5fk	12	12	and	and	CC
cord-290218-dvyeg5fk	12	13	remdesivir	remdesivir	NNP
cord-290218-dvyeg5fk	12	14	were	be	VBD
cord-290218-dvyeg5fk	12	15	reported	report	VBN
cord-290218-dvyeg5fk	12	16	,	,	,
cord-290218-dvyeg5fk	12	17	providing	provide	VBG
cord-290218-dvyeg5fk	12	18	insights	insight	NNS
cord-290218-dvyeg5fk	12	19	into	into	IN
cord-290218-dvyeg5fk	12	20	the	the	DT
cord-290218-dvyeg5fk	12	21	mechanisms	mechanism	NNS
cord-290218-dvyeg5fk	12	22	of	of	IN
cord-290218-dvyeg5fk	12	23	RNA	RNA	NNP
cord-290218-dvyeg5fk	12	24	recognition	recognition	NN
cord-290218-dvyeg5fk	12	25	by	by	IN
cord-290218-dvyeg5fk	12	26	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	12	27	.	.	.
cord-290218-dvyeg5fk	13	1	These	these	DT
cord-290218-dvyeg5fk	13	2	structures	structure	NNS
cord-290218-dvyeg5fk	13	3	also	also	RB
cord-290218-dvyeg5fk	13	4	reveal	reveal	VBP
cord-290218-dvyeg5fk	13	5	the	the	DT
cord-290218-dvyeg5fk	13	6	mechanism	mechanism	NN
cord-290218-dvyeg5fk	13	7	of	of	IN
cord-290218-dvyeg5fk	13	8	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	13	9	inhibition	inhibition	NN
cord-290218-dvyeg5fk	13	10	by	by	IN
cord-290218-dvyeg5fk	13	11	nucleotide	nucleotide	JJ
cord-290218-dvyeg5fk	13	12	inhibitors	inhibitor	NNS
cord-290218-dvyeg5fk	13	13	and	and	CC
cord-290218-dvyeg5fk	13	14	offer	offer	VBP
cord-290218-dvyeg5fk	13	15	a	a	DT
cord-290218-dvyeg5fk	13	16	molecular	molecular	JJ
cord-290218-dvyeg5fk	13	17	template	template	NN
cord-290218-dvyeg5fk	13	18	for	for	IN
cord-290218-dvyeg5fk	13	19	the	the	DT
cord-290218-dvyeg5fk	13	20	development	development	NN
cord-290218-dvyeg5fk	13	21	of	of	IN
cord-290218-dvyeg5fk	13	22	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	13	23	-	-	HYPH
cord-290218-dvyeg5fk	13	24	targeting	target	VBG
cord-290218-dvyeg5fk	13	25	drugs	drug	NNS
cord-290218-dvyeg5fk	13	26	.	.	.
cord-290218-dvyeg5fk	14	1	This	this	DT
cord-290218-dvyeg5fk	14	2	review	review	NN
cord-290218-dvyeg5fk	14	3	discusses	discuss	VBZ
cord-290218-dvyeg5fk	14	4	the	the	DT
cord-290218-dvyeg5fk	14	5	recognition	recognition	NN
cord-290218-dvyeg5fk	14	6	mechanism	mechanism	NN
cord-290218-dvyeg5fk	14	7	of	of	IN
cord-290218-dvyeg5fk	14	8	RNA	RNA	NNP
cord-290218-dvyeg5fk	14	9	and	and	CC
cord-290218-dvyeg5fk	14	10	nucleotide	nucleotide	JJ
cord-290218-dvyeg5fk	14	11	inhibitor	inhibitor	NN
cord-290218-dvyeg5fk	14	12	by	by	IN
cord-290218-dvyeg5fk	14	13	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	14	14	,	,	,
cord-290218-dvyeg5fk	14	15	and	and	CC
cord-290218-dvyeg5fk	14	16	its	-PRON-	PRP$
cord-290218-dvyeg5fk	14	17	implication	implication	NN
cord-290218-dvyeg5fk	14	18	in	in	IN
cord-290218-dvyeg5fk	14	19	drug	drug	NN
cord-290218-dvyeg5fk	14	20	discovery	discovery	NN
cord-290218-dvyeg5fk	14	21	.	.	.
cord-290218-dvyeg5fk	15	1	Coronavirus	Coronavirus	NNP
cord-290218-dvyeg5fk	15	2	disease	disease	NN
cord-290218-dvyeg5fk	15	3	2019	2019	CD
cord-290218-dvyeg5fk	15	4	(	(	-LRB-
cord-290218-dvyeg5fk	15	5	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	15	6	)	)	-RRB-
cord-290218-dvyeg5fk	15	7	caused	cause	VBN
cord-290218-dvyeg5fk	15	8	by	by	IN
cord-290218-dvyeg5fk	15	9	severe	severe	JJ
cord-290218-dvyeg5fk	15	10	acute	acute	JJ
cord-290218-dvyeg5fk	15	11	respiratory	respiratory	JJ
cord-290218-dvyeg5fk	15	12	syndrome	syndrome	NN
cord-290218-dvyeg5fk	15	13	coronavirus-2	coronavirus-2	NN
cord-290218-dvyeg5fk	16	1	(	(	-LRB-
cord-290218-dvyeg5fk	16	2	SARS	SARS	NNP
cord-290218-dvyeg5fk	16	3	-	-	HYPH
cord-290218-dvyeg5fk	16	4	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	16	5	)	)	-RRB-
cord-290218-dvyeg5fk	16	6	was	be	VBD
cord-290218-dvyeg5fk	16	7	initially	initially	RB
cord-290218-dvyeg5fk	16	8	emerged	emerge	VBN
cord-290218-dvyeg5fk	16	9	in	in	IN
cord-290218-dvyeg5fk	16	10	December	December	NNP
cord-290218-dvyeg5fk	16	11	2019	2019	CD
cord-290218-dvyeg5fk	16	12	[	[	-LRB-
cord-290218-dvyeg5fk	16	13	1	1	CD
cord-290218-dvyeg5fk	16	14	,	,	,
cord-290218-dvyeg5fk	16	15	2	2	CD
cord-290218-dvyeg5fk	16	16	]	]	-RRB-
cord-290218-dvyeg5fk	16	17	.	.	.
cord-290218-dvyeg5fk	17	1	The	the	DT
cord-290218-dvyeg5fk	17	2	exponential	exponential	JJ
cord-290218-dvyeg5fk	17	3	growth	growth	NN
cord-290218-dvyeg5fk	17	4	of	of	IN
cord-290218-dvyeg5fk	17	5	infections	infection	NNS
cord-290218-dvyeg5fk	17	6	and	and	CC
cord-290218-dvyeg5fk	17	7	death	death	NN
cord-290218-dvyeg5fk	17	8	cases	case	NNS
cord-290218-dvyeg5fk	17	9	makes	make	VBZ
cord-290218-dvyeg5fk	17	10	COVID-19	covid-19	VB
cord-290218-dvyeg5fk	17	11	a	a	DT
cord-290218-dvyeg5fk	17	12	worldwide	worldwide	JJ
cord-290218-dvyeg5fk	17	13	health	health	NN
cord-290218-dvyeg5fk	17	14	threat	threat	NN
cord-290218-dvyeg5fk	17	15	,	,	,
cord-290218-dvyeg5fk	17	16	and	and	CC
cord-290218-dvyeg5fk	17	17	the	the	DT
cord-290218-dvyeg5fk	17	18	World	World	NNP
cord-290218-dvyeg5fk	17	19	Health	Health	NNP
cord-290218-dvyeg5fk	17	20	Organization	Organization	NNP
cord-290218-dvyeg5fk	17	21	(	(	-LRB-
cord-290218-dvyeg5fk	17	22	WHO	who	WP
cord-290218-dvyeg5fk	17	23	)	)	-RRB-
cord-290218-dvyeg5fk	17	24	declares	declare	VBZ
cord-290218-dvyeg5fk	17	25	it	-PRON-	PRP
cord-290218-dvyeg5fk	17	26	a	a	DT
cord-290218-dvyeg5fk	17	27	global	global	JJ
cord-290218-dvyeg5fk	17	28	pandemic	pandemic	NN
cord-290218-dvyeg5fk	17	29	in	in	IN
cord-290218-dvyeg5fk	17	30	March	March	NNP
cord-290218-dvyeg5fk	17	31	2020	2020	CD
cord-290218-dvyeg5fk	17	32	.	.	.
cord-290218-dvyeg5fk	18	1	There	there	EX
cord-290218-dvyeg5fk	18	2	have	have	VBP
cord-290218-dvyeg5fk	18	3	been	be	VBN
cord-290218-dvyeg5fk	18	4	over	over	IN
cord-290218-dvyeg5fk	18	5	20	20	CD
cord-290218-dvyeg5fk	18	6	million	million	CD
cord-290218-dvyeg5fk	18	7	infections	infection	NNS
cord-290218-dvyeg5fk	18	8	and	and	CC
cord-290218-dvyeg5fk	18	9	800,000	800,000	CD
cord-290218-dvyeg5fk	18	10	deaths	death	NNS
cord-290218-dvyeg5fk	18	11	in	in	IN
cord-290218-dvyeg5fk	18	12	188	188	CD
cord-290218-dvyeg5fk	18	13	countries	country	NNS
cord-290218-dvyeg5fk	18	14	as	as	IN
cord-290218-dvyeg5fk	18	15	of	of	IN
cord-290218-dvyeg5fk	18	16	August	August	NNP
cord-290218-dvyeg5fk	18	17	2020	2020	CD
cord-290218-dvyeg5fk	18	18	(	(	-LRB-
cord-290218-dvyeg5fk	18	19	GISAID	GISAID	NNP
cord-290218-dvyeg5fk	18	20	database	database	NN
cord-290218-dvyeg5fk	18	21	)	)	-RRB-
cord-290218-dvyeg5fk	18	22	.	.	.
cord-290218-dvyeg5fk	19	1	Genome	genome	NN
cord-290218-dvyeg5fk	19	2	sequence	sequence	NN
cord-290218-dvyeg5fk	19	3	analysis	analysis	NN
cord-290218-dvyeg5fk	19	4	has	have	VBZ
cord-290218-dvyeg5fk	19	5	revealed	reveal	VBN
cord-290218-dvyeg5fk	19	6	that	that	IN
cord-290218-dvyeg5fk	19	7	SARS	SARS	NNP
cord-290218-dvyeg5fk	19	8	-	-	HYPH
cord-290218-dvyeg5fk	19	9	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	19	10	belongs	belong	VBZ
cord-290218-dvyeg5fk	19	11	to	to	IN
cord-290218-dvyeg5fk	19	12	the	the	DT
cord-290218-dvyeg5fk	19	13	coronaviridae	coronaviridae	NNP
cord-290218-dvyeg5fk	19	14	family	family	NN
cord-290218-dvyeg5fk	19	15	.	.	.
cord-290218-dvyeg5fk	20	1	Its	-PRON-	PRP$
cord-290218-dvyeg5fk	20	2	sequence	sequence	NN
cord-290218-dvyeg5fk	20	3	is	be	VBZ
cord-290218-dvyeg5fk	20	4	closely	closely	RB
cord-290218-dvyeg5fk	20	5	related	related	JJ
cord-290218-dvyeg5fk	20	6	to	to	IN
cord-290218-dvyeg5fk	20	7	the	the	DT
cord-290218-dvyeg5fk	20	8	severe	severe	JJ
cord-290218-dvyeg5fk	20	9	acute	acute	JJ
cord-290218-dvyeg5fk	20	10	respiratory	respiratory	JJ
cord-290218-dvyeg5fk	20	11	syndrome	syndrome	NN
cord-290218-dvyeg5fk	20	12	activity	activity	NN
cord-290218-dvyeg5fk	20	13	.	.	.
cord-290218-dvyeg5fk	21	1	Motif	Motif	NNP
cord-290218-dvyeg5fk	21	2	F	F	NNP
cord-290218-dvyeg5fk	21	3	(	(	-LRB-
cord-290218-dvyeg5fk	21	4	residues	residue	NNS
cord-290218-dvyeg5fk	21	5	L544	l544	NN
cord-290218-dvyeg5fk	21	6	to	to	IN
cord-290218-dvyeg5fk	21	7	V557	V557	NNP
cord-290218-dvyeg5fk	21	8	)	)	-RRB-
cord-290218-dvyeg5fk	21	9	interacts	interact	VBZ
cord-290218-dvyeg5fk	21	10	with	with	IN
cord-290218-dvyeg5fk	21	11	the	the	DT
cord-290218-dvyeg5fk	21	12	phosphate	phosphate	NN
cord-290218-dvyeg5fk	21	13	group	group	NN
cord-290218-dvyeg5fk	21	14	of	of	IN
cord-290218-dvyeg5fk	21	15	incoming	incoming	JJ
cord-290218-dvyeg5fk	21	16	NTP	NTP	NNP
cord-290218-dvyeg5fk	21	17	.	.	.
cord-290218-dvyeg5fk	22	1	Structurally	structurally	RB
cord-290218-dvyeg5fk	22	2	,	,	,
cord-290218-dvyeg5fk	22	3	the	the	DT
cord-290218-dvyeg5fk	22	4	side	side	NN
cord-290218-dvyeg5fk	22	5	chains	chain	NNS
cord-290218-dvyeg5fk	22	6	of	of	IN
cord-290218-dvyeg5fk	22	7	K545	K545	NNP
cord-290218-dvyeg5fk	22	8	and	and	CC
cord-290218-dvyeg5fk	22	9	R555	r555	CD
cord-290218-dvyeg5fk	22	10	contact	contact	NN
cord-290218-dvyeg5fk	22	11	with	with	IN
cord-290218-dvyeg5fk	22	12	the	the	DT
cord-290218-dvyeg5fk	22	13	+1	+1	HYPH
cord-290218-dvyeg5fk	22	14	base	base	NN
cord-290218-dvyeg5fk	22	15	to	to	TO
cord-290218-dvyeg5fk	22	16	direct	direct	VB
cord-290218-dvyeg5fk	22	17	the	the	DT
cord-290218-dvyeg5fk	22	18	incoming	incoming	JJ
cord-290218-dvyeg5fk	22	19	NTP	NTP	NNP
cord-290218-dvyeg5fk	22	20	to	to	IN
cord-290218-dvyeg5fk	22	21	the	the	DT
cord-290218-dvyeg5fk	22	22	correct	correct	JJ
cord-290218-dvyeg5fk	22	23	position	position	NN
cord-290218-dvyeg5fk	22	24	for	for	IN
cord-290218-dvyeg5fk	22	25	catalysis	catalysis	NN
cord-290218-dvyeg5fk	22	26	.	.	.
cord-290218-dvyeg5fk	23	1	Motif	motif	NN
cord-290218-dvyeg5fk	23	2	G	g	NN
cord-290218-dvyeg5fk	23	3	(	(	-LRB-
cord-290218-dvyeg5fk	23	4	residues	residue	NNS
cord-290218-dvyeg5fk	23	5	D499	D499	NNP
cord-290218-dvyeg5fk	23	6	to	to	IN
cord-290218-dvyeg5fk	23	7	L514	L514	NNP
cord-290218-dvyeg5fk	23	8	)	)	-RRB-
cord-290218-dvyeg5fk	23	9	interacts	interact	VBZ
cord-290218-dvyeg5fk	23	10	with	with	IN
cord-290218-dvyeg5fk	23	11	the	the	DT
cord-290218-dvyeg5fk	23	12	template	template	NN
cord-290218-dvyeg5fk	23	13	strand	strand	NN
cord-290218-dvyeg5fk	23	14	and	and	CC
cord-290218-dvyeg5fk	23	15	may	may	MD
cord-290218-dvyeg5fk	23	16	direct	direct	VB
cord-290218-dvyeg5fk	23	17	the	the	DT
cord-290218-dvyeg5fk	23	18	RNA	RNA	NNP
cord-290218-dvyeg5fk	23	19	template	template	NN
cord-290218-dvyeg5fk	23	20	to	to	IN
cord-290218-dvyeg5fk	23	21	the	the	DT
cord-290218-dvyeg5fk	23	22	active	active	JJ
cord-290218-dvyeg5fk	23	23	catalytic	catalytic	JJ
cord-290218-dvyeg5fk	23	24	site	site	NN
cord-290218-dvyeg5fk	23	25	(	(	-LRB-
cord-290218-dvyeg5fk	23	26	Fig	Fig	NNP
cord-290218-dvyeg5fk	23	27	.	.	.
cord-290218-dvyeg5fk	23	28	2E	2E	NNP
cord-290218-dvyeg5fk	23	29	)	)	-RRB-
cord-290218-dvyeg5fk	23	30	.	.	.
cord-290218-dvyeg5fk	24	1	The	the	DT
cord-290218-dvyeg5fk	24	2	recent	recent	JJ
cord-290218-dvyeg5fk	24	3	structures	structure	NNS
cord-290218-dvyeg5fk	24	4	of	of	IN
cord-290218-dvyeg5fk	24	5	SARS	SARS	NNP
cord-290218-dvyeg5fk	24	6	-	-	HYPH
cord-290218-dvyeg5fk	24	7	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	24	8	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	24	9	in	in	IN
cord-290218-dvyeg5fk	24	10	complex	complex	NN
cord-290218-dvyeg5fk	24	11	with	with	IN
cord-290218-dvyeg5fk	24	12	double	double	RB
cord-290218-dvyeg5fk	24	13	-	-	HYPH
cord-290218-dvyeg5fk	24	14	stranded	strand	VBN
cord-290218-dvyeg5fk	24	15	RNA	RNA	NNP
cord-290218-dvyeg5fk	24	16	helix	helix	NN
cord-290218-dvyeg5fk	24	17	reveal	reveal	VB
cord-290218-dvyeg5fk	24	18	the	the	DT
cord-290218-dvyeg5fk	24	19	recognition	recognition	NN
cord-290218-dvyeg5fk	24	20	mechanism	mechanism	NN
cord-290218-dvyeg5fk	24	21	of	of	IN
cord-290218-dvyeg5fk	24	22	substrate	substrate	NN
cord-290218-dvyeg5fk	24	23	RNA	RNA	NNP
cord-290218-dvyeg5fk	24	24	by	by	IN
cord-290218-dvyeg5fk	24	25	SARS	SARS	NNP
cord-290218-dvyeg5fk	24	26	-	-	HYPH
cord-290218-dvyeg5fk	24	27	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	25	1	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	25	2	[	[	-LRB-
cord-290218-dvyeg5fk	25	3	17	17	CD
cord-290218-dvyeg5fk	25	4	,	,	,
cord-290218-dvyeg5fk	25	5	18	18	CD
cord-290218-dvyeg5fk	25	6	]	]	-RRB-
cord-290218-dvyeg5fk	25	7	.	.	.
cord-290218-dvyeg5fk	26	1	Like	like	IN
cord-290218-dvyeg5fk	26	2	other	other	JJ
cord-290218-dvyeg5fk	26	3	RNA	RNA	NNP
cord-290218-dvyeg5fk	26	4	polymerases	polymerase	NNS
cord-290218-dvyeg5fk	26	5	,	,	,
cord-290218-dvyeg5fk	26	6	the	the	DT
cord-290218-dvyeg5fk	26	7	primer	primer	NN
cord-290218-dvyeg5fk	26	8	-	-	HYPH
cord-290218-dvyeg5fk	26	9	template	template	NN
cord-290218-dvyeg5fk	26	10	entry	entry	NN
cord-290218-dvyeg5fk	26	11	,	,	,
cord-290218-dvyeg5fk	26	12	NTP	NTP	NNP
cord-290218-dvyeg5fk	26	13	entry	entry	NN
cord-290218-dvyeg5fk	26	14	,	,	,
cord-290218-dvyeg5fk	26	15	and	and	CC
cord-290218-dvyeg5fk	26	16	the	the	DT
cord-290218-dvyeg5fk	26	17	nascent	nascent	JJ
cord-290218-dvyeg5fk	26	18	strand	strand	NN
cord-290218-dvyeg5fk	26	19	exit	exit	NN
cord-290218-dvyeg5fk	26	20	routes	route	NNS
cord-290218-dvyeg5fk	26	21	are	be	VBP
cord-290218-dvyeg5fk	26	22	positively	positively	RB
cord-290218-dvyeg5fk	26	23	charged	charge	VBN
cord-290218-dvyeg5fk	26	24	and	and	CC
cord-290218-dvyeg5fk	26	25	solvent	solvent	NN
cord-290218-dvyeg5fk	26	26	accessible	accessible	JJ
cord-290218-dvyeg5fk	26	27	,	,	,
cord-290218-dvyeg5fk	26	28	providing	provide	VBG
cord-290218-dvyeg5fk	26	29	a	a	DT
cord-290218-dvyeg5fk	26	30	preferable	preferable	JJ
cord-290218-dvyeg5fk	26	31	environment	environment	NN
cord-290218-dvyeg5fk	26	32	for	for	IN
cord-290218-dvyeg5fk	26	33	RNA	rna	NN
cord-290218-dvyeg5fk	26	34	binding	bind	VBG
cord-290218-dvyeg5fk	26	35	(	(	-LRB-
cord-290218-dvyeg5fk	26	36	Fig	Fig	NNP
cord-290218-dvyeg5fk	26	37	.	.	.
cord-290218-dvyeg5fk	26	38	3A	3A	NNP
cord-290218-dvyeg5fk	26	39	)	)	-RRB-
cord-290218-dvyeg5fk	26	40	.	.	.
cord-290218-dvyeg5fk	27	1	The	the	DT
cord-290218-dvyeg5fk	27	2	primer	primer	NN
cord-290218-dvyeg5fk	27	3	-	-	HYPH
cord-290218-dvyeg5fk	27	4	template	template	NN
cord-290218-dvyeg5fk	27	5	RNA	RNA	NNP
cord-290218-dvyeg5fk	27	6	is	be	VBZ
cord-290218-dvyeg5fk	27	7	embraced	embrace	VBN
cord-290218-dvyeg5fk	27	8	by	by	IN
cord-290218-dvyeg5fk	27	9	the	the	DT
cord-290218-dvyeg5fk	27	10	finger	finger	NN
cord-290218-dvyeg5fk	27	11	-	-	HYPH
cord-290218-dvyeg5fk	27	12	palm	palm	NN
cord-290218-dvyeg5fk	27	13	-	-	HYPH
cord-290218-dvyeg5fk	27	14	thumb	thumb	NN
cord-290218-dvyeg5fk	27	15	subdomains	subdomain	NNS
cord-290218-dvyeg5fk	27	16	(	(	-LRB-
cord-290218-dvyeg5fk	27	17	Fig	Fig	NNP
cord-290218-dvyeg5fk	27	18	.	.	.
cord-290218-dvyeg5fk	27	19	3B	3B	NNP
cord-290218-dvyeg5fk	27	20	)	)	-RRB-
cord-290218-dvyeg5fk	27	21	.	.	.
cord-290218-dvyeg5fk	28	1	A	a	DT
cord-290218-dvyeg5fk	28	2	total	total	NN
cord-290218-dvyeg5fk	28	3	of	of	IN
cord-290218-dvyeg5fk	28	4	41	41	CD
cord-290218-dvyeg5fk	28	5	residues	residue	NNS
cord-290218-dvyeg5fk	28	6	from	from	IN
cord-290218-dvyeg5fk	28	7	nsp12	nsp12	ADD
cord-290218-dvyeg5fk	28	8	direct	direct	JJ
cord-290218-dvyeg5fk	28	9	contact	contact	NN
cord-290218-dvyeg5fk	28	10	with	with	IN
cord-290218-dvyeg5fk	28	11	helical	helical	JJ
cord-290218-dvyeg5fk	28	12	RNA	RNA	NNP
cord-290218-dvyeg5fk	28	13	,	,	,
cord-290218-dvyeg5fk	28	14	of	of	IN
cord-290218-dvyeg5fk	28	15	which	which	WDT
cord-290218-dvyeg5fk	28	16	26	26	CD
cord-290218-dvyeg5fk	28	17	residues	residue	NNS
cord-290218-dvyeg5fk	28	18	to	to	IN
cord-290218-dvyeg5fk	28	19	the	the	DT
cord-290218-dvyeg5fk	28	20	template	template	NN
cord-290218-dvyeg5fk	28	21	strand	strand	NN
cord-290218-dvyeg5fk	28	22	and	and	CC
cord-290218-dvyeg5fk	28	23	15	15	CD
cord-290218-dvyeg5fk	28	24	to	to	IN
cord-290218-dvyeg5fk	28	25	the	the	DT
cord-290218-dvyeg5fk	28	26	primer	primer	NN
cord-290218-dvyeg5fk	28	27	strand	strand	NN
cord-290218-dvyeg5fk	28	28	.	.	.
cord-290218-dvyeg5fk	29	1	No	no	DT
cord-290218-dvyeg5fk	29	2	interactions	interaction	NNS
cord-290218-dvyeg5fk	29	3	are	be	VBP
cord-290218-dvyeg5fk	29	4	observed	observe	VBN
cord-290218-dvyeg5fk	29	5	between	between	IN
cord-290218-dvyeg5fk	29	6	base	base	NN
cord-290218-dvyeg5fk	29	7	pairs	pair	NNS
cord-290218-dvyeg5fk	29	8	of	of	IN
cord-290218-dvyeg5fk	29	9	RNA	RNA	NNP
cord-290218-dvyeg5fk	29	10	and	and	CC
cord-290218-dvyeg5fk	29	11	residues	residue	NNS
cord-290218-dvyeg5fk	29	12	from	from	IN
cord-290218-dvyeg5fk	29	13	nsp12	nsp12	CD
cord-290218-dvyeg5fk	29	14	,	,	,
cord-290218-dvyeg5fk	29	15	providing	provide	VBG
cord-290218-dvyeg5fk	29	16	a	a	DT
cord-290218-dvyeg5fk	29	17	structural	structural	JJ
cord-290218-dvyeg5fk	29	18	basis	basis	NN
cord-290218-dvyeg5fk	29	19	for	for	IN
cord-290218-dvyeg5fk	29	20	RNA	RNA	NNP
cord-290218-dvyeg5fk	29	21	sequence	sequence	NN
cord-290218-dvyeg5fk	29	22	-	-	HYPH
cord-290218-dvyeg5fk	29	23	independent	independent	JJ
cord-290218-dvyeg5fk	29	24	binding	binding	NN
cord-290218-dvyeg5fk	29	25	of	of	IN
cord-290218-dvyeg5fk	29	26	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	29	27	.	.	.
cord-290218-dvyeg5fk	30	1	Additionally	additionally	RB
cord-290218-dvyeg5fk	30	2	,	,	,
cord-290218-dvyeg5fk	30	3	most	most	JJS
cord-290218-dvyeg5fk	30	4	of	of	IN
cord-290218-dvyeg5fk	30	5	these	these	DT
cord-290218-dvyeg5fk	30	6	interactions	interaction	NNS
cord-290218-dvyeg5fk	30	7	are	be	VBP
cord-290218-dvyeg5fk	30	8	mediated	mediate	VBN
cord-290218-dvyeg5fk	30	9	by	by	IN
cord-290218-dvyeg5fk	30	10	the	the	DT
cord-290218-dvyeg5fk	30	11	phosphate	phosphate	NN
cord-290218-dvyeg5fk	30	12	-	-	HYPH
cord-290218-dvyeg5fk	30	13	ribose	ribose	NN
cord-290218-dvyeg5fk	30	14	backbone	backbone	NN
cord-290218-dvyeg5fk	30	15	,	,	,
cord-290218-dvyeg5fk	30	16	especially	especially	RB
cord-290218-dvyeg5fk	30	17	the	the	DT
cord-290218-dvyeg5fk	30	18	2'-OH	2'-oh	CD
cord-290218-dvyeg5fk	30	19	groups	group	NNS
cord-290218-dvyeg5fk	30	20	,	,	,
cord-290218-dvyeg5fk	30	21	which	which	WDT
cord-290218-dvyeg5fk	30	22	offers	offer	VBZ
cord-290218-dvyeg5fk	30	23	a	a	DT
cord-290218-dvyeg5fk	30	24	structural	structural	JJ
cord-290218-dvyeg5fk	30	25	explanation	explanation	NN
cord-290218-dvyeg5fk	30	26	for	for	IN
cord-290218-dvyeg5fk	30	27	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	30	28	to	to	TO
cord-290218-dvyeg5fk	30	29	distinguish	distinguish	VB
cord-290218-dvyeg5fk	30	30	RNA	RNA	NNP
cord-290218-dvyeg5fk	30	31	from	from	IN
cord-290218-dvyeg5fk	30	32	DNA	DNA	NNP
cord-290218-dvyeg5fk	30	33	[	[	-LRB-
cord-290218-dvyeg5fk	30	34	17	17	CD
cord-290218-dvyeg5fk	30	35	]	]	-RRB-
cord-290218-dvyeg5fk	30	36	.	.	.
cord-290218-dvyeg5fk	31	1	Interestingly	interestingly	RB
cord-290218-dvyeg5fk	31	2	,	,	,
cord-290218-dvyeg5fk	31	3	the	the	DT
cord-290218-dvyeg5fk	31	4	structure	structure	NN
cord-290218-dvyeg5fk	31	5	of	of	IN
cord-290218-dvyeg5fk	31	6	complexed	complexed	JJ
cord-290218-dvyeg5fk	31	7	nsp12	nsp12	CD
cord-290218-dvyeg5fk	31	8	is	be	VBZ
cord-290218-dvyeg5fk	31	9	almost	almost	RB
cord-290218-dvyeg5fk	31	10	identical	identical	JJ
cord-290218-dvyeg5fk	31	11	to	to	IN
cord-290218-dvyeg5fk	31	12	nsp12	nsp12	CD
cord-290218-dvyeg5fk	31	13	in	in	IN
cord-290218-dvyeg5fk	31	14	apo	apo	NNP
cord-290218-dvyeg5fk	31	15	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	31	16	,	,	,
cord-290218-dvyeg5fk	31	17	with	with	IN
cord-290218-dvyeg5fk	31	18	an	an	DT
cord-290218-dvyeg5fk	31	19	RMSD	rmsd	NN
cord-290218-dvyeg5fk	31	20	of	of	IN
cord-290218-dvyeg5fk	31	21	0.5	0.5	CD
cord-290218-dvyeg5fk	31	22	Å	å	NN
cord-290218-dvyeg5fk	31	23	[	[	-LRB-
cord-290218-dvyeg5fk	31	24	17	17	CD
cord-290218-dvyeg5fk	31	25	]	]	-RRB-
cord-290218-dvyeg5fk	31	26	,	,	,
cord-290218-dvyeg5fk	31	27	coinciding	coincide	VBG
cord-290218-dvyeg5fk	31	28	with	with	IN
cord-290218-dvyeg5fk	31	29	the	the	DT
cord-290218-dvyeg5fk	31	30	high	high	JJ
cord-290218-dvyeg5fk	31	31	processivity	processivity	NN
cord-290218-dvyeg5fk	31	32	of	of	IN
cord-290218-dvyeg5fk	31	33	the	the	DT
cord-290218-dvyeg5fk	31	34	viral	viral	JJ
cord-290218-dvyeg5fk	31	35	RNA	RNA	NNP
cord-290218-dvyeg5fk	31	36	polymerase	polymerase	NN
cord-290218-dvyeg5fk	31	37	,	,	,
cord-290218-dvyeg5fk	31	38	which	which	WDT
cord-290218-dvyeg5fk	31	39	does	do	VBZ
cord-290218-dvyeg5fk	31	40	not	not	RB
cord-290218-dvyeg5fk	31	41	need	need	VB
cord-290218-dvyeg5fk	31	42	to	to	TO
cord-290218-dvyeg5fk	31	43	consume	consume	VB
cord-290218-dvyeg5fk	31	44	extra	extra	JJ
cord-290218-dvyeg5fk	31	45	energy	energy	NN
cord-290218-dvyeg5fk	31	46	for	for	IN
cord-290218-dvyeg5fk	31	47	conformation	conformation	NN
cord-290218-dvyeg5fk	31	48	changes	change	NNS
cord-290218-dvyeg5fk	31	49	in	in	IN
cord-290218-dvyeg5fk	31	50	the	the	DT
cord-290218-dvyeg5fk	31	51	active	active	JJ
cord-290218-dvyeg5fk	31	52	site	site	NN
cord-290218-dvyeg5fk	31	53	during	during	IN
cord-290218-dvyeg5fk	31	54	the	the	DT
cord-290218-dvyeg5fk	31	55	replication	replication	NN
cord-290218-dvyeg5fk	31	56	cycle	cycle	NN
cord-290218-dvyeg5fk	31	57	(	(	-LRB-
cord-290218-dvyeg5fk	31	58	Fig	fig	NN
cord-290218-dvyeg5fk	31	59	.	.	.
cord-290218-dvyeg5fk	31	60	3B	3B	NNP
cord-290218-dvyeg5fk	31	61	)	)	-RRB-
cord-290218-dvyeg5fk	31	62	.	.	.
cord-290218-dvyeg5fk	32	1	Although	although	IN
cord-290218-dvyeg5fk	32	2	nearly	nearly	RB
cord-290218-dvyeg5fk	32	3	identical	identical	JJ
cord-290218-dvyeg5fk	32	4	conformation	conformation	NN
cord-290218-dvyeg5fk	32	5	between	between	IN
cord-290218-dvyeg5fk	32	6	the	the	DT
cord-290218-dvyeg5fk	32	7	apo	apo	NNP
cord-290218-dvyeg5fk	32	8	and	and	CC
cord-290218-dvyeg5fk	32	9	RNA	RNA	NNP
cord-290218-dvyeg5fk	32	10	bound	bind	VBD
cord-290218-dvyeg5fk	32	11	nsp12	nsp12	CD
cord-290218-dvyeg5fk	32	12	structures	structure	NNS
cord-290218-dvyeg5fk	32	13	,	,	,
cord-290218-dvyeg5fk	32	14	several	several	JJ
cord-290218-dvyeg5fk	32	15	subtle	subtle	JJ
cord-290218-dvyeg5fk	32	16	structural	structural	JJ
cord-290218-dvyeg5fk	32	17	rearrangements	rearrangement	NNS
cord-290218-dvyeg5fk	32	18	can	can	MD
cord-290218-dvyeg5fk	32	19	still	still	RB
cord-290218-dvyeg5fk	32	20	be	be	VB
cord-290218-dvyeg5fk	32	21	observed	observe	VBN
cord-290218-dvyeg5fk	32	22	(	(	-LRB-
cord-290218-dvyeg5fk	32	23	Fig.3C	Fig.3C	NNP
cord-290218-dvyeg5fk	32	24	)	)	-RRB-
cord-290218-dvyeg5fk	32	25	.	.	.
cord-290218-dvyeg5fk	33	1	Compared	compare	VBN
cord-290218-dvyeg5fk	33	2	to	to	IN
cord-290218-dvyeg5fk	33	3	the	the	DT
cord-290218-dvyeg5fk	33	4	structure	structure	NN
cord-290218-dvyeg5fk	33	5	of	of	IN
cord-290218-dvyeg5fk	33	6	apo	apo	NNP
cord-290218-dvyeg5fk	33	7	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	33	8	complex	complex	NN
cord-290218-dvyeg5fk	33	9	,	,	,
cord-290218-dvyeg5fk	33	10	the	the	DT
cord-290218-dvyeg5fk	33	11	loop	loop	NN
cord-290218-dvyeg5fk	33	12	in	in	IN
cord-290218-dvyeg5fk	33	13	motif	motif	NN
cord-290218-dvyeg5fk	33	14	G	g	NN
cord-290218-dvyeg5fk	33	15	(	(	-LRB-
cord-290218-dvyeg5fk	33	16	residues	residue	NNS
cord-290218-dvyeg5fk	33	17	D449	D449	''
cord-290218-dvyeg5fk	33	18	to	to	IN
cord-290218-dvyeg5fk	33	19	L514	L514	NNP
cord-290218-dvyeg5fk	33	20	)	)	-RRB-
cord-290218-dvyeg5fk	33	21	moves	move	VBZ
cord-290218-dvyeg5fk	33	22	outward	outward	RB
cord-290218-dvyeg5fk	33	23	by	by	IN
cord-290218-dvyeg5fk	33	24	2.2	2.2	CD
cord-290218-dvyeg5fk	33	25	-	-	SYM
cord-290218-dvyeg5fk	33	26	3.0	3.0	CD
cord-290218-dvyeg5fk	33	27	Å	å	NN
cord-290218-dvyeg5fk	33	28	(	(	-LRB-
cord-290218-dvyeg5fk	33	29	as	as	IN
cord-290218-dvyeg5fk	33	30	measured	measure	VBN
cord-290218-dvyeg5fk	33	31	by	by	IN
cord-290218-dvyeg5fk	33	32	nsp12	nsp12	CD
cord-290218-dvyeg5fk	33	33	residue	residue	NN
cord-290218-dvyeg5fk	33	34	S501	S501	NNP
cord-290218-dvyeg5fk	33	35	)	)	-RRB-
cord-290218-dvyeg5fk	33	36	,	,	,
cord-290218-dvyeg5fk	33	37	and	and	CC
cord-290218-dvyeg5fk	33	38	loop	loop	NN
cord-290218-dvyeg5fk	33	39	(	(	-LRB-
cord-290218-dvyeg5fk	33	40	residues	residue	NNS
cord-290218-dvyeg5fk	33	41	S682	S682	VBG
cord-290218-dvyeg5fk	33	42	to	to	IN
cord-290218-dvyeg5fk	33	43	T686	t686	NN
cord-290218-dvyeg5fk	33	44	)	)	-RRB-
cord-290218-dvyeg5fk	33	45	in	in	IN
cord-290218-dvyeg5fk	33	46	motif	motif	NN
cord-290218-dvyeg5fk	33	47	B	b	NN
cord-290218-dvyeg5fk	33	48	by	by	IN
cord-290218-dvyeg5fk	33	49	1.7	1.7	CD
cord-290218-dvyeg5fk	33	50	-	-	SYM
cord-290218-dvyeg5fk	33	51	2.0	2.0	CD
cord-290218-dvyeg5fk	33	52	Å	å	NN
cord-290218-dvyeg5fk	33	53	(	(	-LRB-
cord-290218-dvyeg5fk	33	54	as	as	IN
cord-290218-dvyeg5fk	33	55	measured	measure	VBN
cord-290218-dvyeg5fk	33	56	by	by	IN
cord-290218-dvyeg5fk	33	57	nsp12	nsp12	CD
cord-290218-dvyeg5fk	33	58	residue	residue	NN
cord-290218-dvyeg5fk	33	59	A685	A685	NNP
cord-290218-dvyeg5fk	33	60	)	)	-RRB-
cord-290218-dvyeg5fk	33	61	[	[	-LRB-
cord-290218-dvyeg5fk	33	62	17	17	CD
cord-290218-dvyeg5fk	33	63	,	,	,
cord-290218-dvyeg5fk	33	64	18	18	CD
cord-290218-dvyeg5fk	33	65	]	]	-RRB-
cord-290218-dvyeg5fk	33	66	.	.	.
cord-290218-dvyeg5fk	34	1	The	the	DT
cord-290218-dvyeg5fk	34	2	loop	loop	NN
cord-290218-dvyeg5fk	34	3	connecting	connect	VBG
cord-290218-dvyeg5fk	34	4	the	the	DT
cord-290218-dvyeg5fk	34	5	first	first	JJ
cord-290218-dvyeg5fk	34	6	and	and	CC
cord-290218-dvyeg5fk	34	7	second	second	JJ
cord-290218-dvyeg5fk	34	8	helices	helix	NNS
cord-290218-dvyeg5fk	34	9	of	of	IN
cord-290218-dvyeg5fk	34	10	the	the	DT
cord-290218-dvyeg5fk	34	11	thumb	thumb	NN
cord-290218-dvyeg5fk	34	12	subdomain	subdomain	NN
cord-290218-dvyeg5fk	34	13	also	also	RB
cord-290218-dvyeg5fk	34	14	shifts	shift	VBZ
cord-290218-dvyeg5fk	34	15	outward	outward	RB
cord-290218-dvyeg5fk	34	16	by	by	IN
cord-290218-dvyeg5fk	34	17	6.0	6.0	CD
cord-290218-dvyeg5fk	34	18	Å	å	NN
cord-290218-dvyeg5fk	34	19	(	(	-LRB-
cord-290218-dvyeg5fk	34	20	as	as	IN
cord-290218-dvyeg5fk	34	21	measured	measure	VBN
cord-290218-dvyeg5fk	34	22	by	by	IN
cord-290218-dvyeg5fk	34	23	nsp	nsp	NN
cord-290218-dvyeg5fk	34	24	residue	residue	NN
cord-290218-dvyeg5fk	34	25	I847	I847	''
cord-290218-dvyeg5fk	34	26	)	)	-RRB-
cord-290218-dvyeg5fk	35	1	[	[	-LRB-
cord-290218-dvyeg5fk	35	2	17	17	CD
cord-290218-dvyeg5fk	35	3	]	]	-RRB-
cord-290218-dvyeg5fk	35	4	.	.	.
cord-290218-dvyeg5fk	36	1	These	these	DT
cord-290218-dvyeg5fk	36	2	conformational	conformational	JJ
cord-290218-dvyeg5fk	36	3	A	a	DT
cord-290218-dvyeg5fk	36	4	recent	recent	JJ
cord-290218-dvyeg5fk	36	5	structure	structure	NN
cord-290218-dvyeg5fk	36	6	of	of	IN
cord-290218-dvyeg5fk	36	7	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	36	8	-	-	HYPH
cord-290218-dvyeg5fk	36	9	RNA	RNA	NNP
cord-290218-dvyeg5fk	36	10	complex	complex	NN
cord-290218-dvyeg5fk	36	11	represents	represent	VBZ
cord-290218-dvyeg5fk	36	12	a	a	DT
cord-290218-dvyeg5fk	36	13	long	long	JJ
cord-290218-dvyeg5fk	36	14	template	template	NN
cord-290218-dvyeg5fk	36	15	-	-	HYPH
cord-290218-dvyeg5fk	36	16	product	product	NN
cord-290218-dvyeg5fk	36	17	helical	helical	JJ
cord-290218-dvyeg5fk	36	18	RNA	RNA	NNP
cord-290218-dvyeg5fk	36	19	strands	strand	NNS
cord-290218-dvyeg5fk	36	20	exiting	exit	VBG
cord-290218-dvyeg5fk	36	21	from	from	IN
cord-290218-dvyeg5fk	36	22	the	the	DT
cord-290218-dvyeg5fk	36	23	active	active	JJ
cord-290218-dvyeg5fk	36	24	core	core	NN
cord-290218-dvyeg5fk	36	25	of	of	IN
cord-290218-dvyeg5fk	36	26	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	36	27	,	,	,
cord-290218-dvyeg5fk	36	28	which	which	WDT
cord-290218-dvyeg5fk	36	29	is	be	VBZ
cord-290218-dvyeg5fk	36	30	not	not	RB
cord-290218-dvyeg5fk	36	31	observed	observe	VBN
cord-290218-dvyeg5fk	36	32	in	in	IN
cord-290218-dvyeg5fk	36	33	other	other	JJ
cord-290218-dvyeg5fk	36	34	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	36	35	-	-	HYPH
cord-290218-dvyeg5fk	36	36	RNA	RNA	NNP
cord-290218-dvyeg5fk	36	37	complex	complex	NN
cord-290218-dvyeg5fk	36	38	[	[	-LRB-
cord-290218-dvyeg5fk	36	39	38	38	CD
cord-290218-dvyeg5fk	36	40	]	]	-RRB-
cord-290218-dvyeg5fk	36	41	.	.	.
cord-290218-dvyeg5fk	37	1	The	the	DT
cord-290218-dvyeg5fk	37	2	two	two	CD
cord-290218-dvyeg5fk	37	3	copies	copy	NNS
cord-290218-dvyeg5fk	37	4	of	of	IN
cord-290218-dvyeg5fk	37	5	nsp8	nsp8	JJ
cord-290218-dvyeg5fk	37	6	exhibit	exhibit	NN
cord-290218-dvyeg5fk	37	7	long	long	JJ
cord-290218-dvyeg5fk	37	8	helical	helical	JJ
cord-290218-dvyeg5fk	37	9	extensions	extension	NNS
cord-290218-dvyeg5fk	37	10	at	at	IN
cord-290218-dvyeg5fk	37	11	their	-PRON-	PRP$
cord-290218-dvyeg5fk	37	12	N	n	CD
cord-290218-dvyeg5fk	37	13	-	-	HYPH
cord-290218-dvyeg5fk	37	14	terminus	terminus	NN
cord-290218-dvyeg5fk	37	15	fragments	fragment	NNS
cord-290218-dvyeg5fk	37	16	,	,	,
cord-290218-dvyeg5fk	37	17	and	and	CC
cord-290218-dvyeg5fk	37	18	serve	serve	VB
cord-290218-dvyeg5fk	37	19	as	as	IN
cord-290218-dvyeg5fk	37	20	platforms	platform	NNS
cord-290218-dvyeg5fk	37	21	for	for	IN
cord-290218-dvyeg5fk	37	22	coordinating	coordinate	VBG
cord-290218-dvyeg5fk	37	23	the	the	DT
cord-290218-dvyeg5fk	37	24	exiting	exit	VBG
cord-290218-dvyeg5fk	37	25	RNA	RNA	NNP
cord-290218-dvyeg5fk	37	26	backbones	backbone	NNS
cord-290218-dvyeg5fk	37	27	,	,	,
cord-290218-dvyeg5fk	37	28	forming	form	VBG
cord-290218-dvyeg5fk	37	29	positively	positively	RB
cord-290218-dvyeg5fk	37	30	charged	charge	VBN
cord-290218-dvyeg5fk	37	31	"	"	''
cord-290218-dvyeg5fk	37	32	sliding	slide	VBG
cord-290218-dvyeg5fk	37	33	poles	pole	NNS
cord-290218-dvyeg5fk	37	34	"	"	''
cord-290218-dvyeg5fk	37	35	(	(	-LRB-
cord-290218-dvyeg5fk	37	36	Fig	Fig	NNP
cord-290218-dvyeg5fk	37	37	.	.	.
cord-290218-dvyeg5fk	37	38	3D	3D	NNP
cord-290218-dvyeg5fk	37	39	)	)	-RRB-
cord-290218-dvyeg5fk	37	40	[	[	-LRB-
cord-290218-dvyeg5fk	37	41	38	38	CD
cord-290218-dvyeg5fk	37	42	]	]	-RRB-
cord-290218-dvyeg5fk	37	43	.	.	.
cord-290218-dvyeg5fk	38	1	These	these	DT
cord-290218-dvyeg5fk	38	2	"	"	``
cord-290218-dvyeg5fk	38	3	sliding	slide	VBG
cord-290218-dvyeg5fk	38	4	poles	pole	NNS
cord-290218-dvyeg5fk	38	5	"	"	''
cord-290218-dvyeg5fk	38	6	are	be	VBP
cord-290218-dvyeg5fk	38	7	stabilized	stabilize	VBN
cord-290218-dvyeg5fk	38	8	by	by	IN
cord-290218-dvyeg5fk	38	9	interactions	interaction	NNS
cord-290218-dvyeg5fk	38	10	formed	form	VBN
cord-290218-dvyeg5fk	38	11	between	between	IN
cord-290218-dvyeg5fk	38	12	the	the	DT
cord-290218-dvyeg5fk	38	13	positively	positively	RB
cord-290218-dvyeg5fk	38	14	charged	charge	VBN
cord-290218-dvyeg5fk	38	15	residues	residue	NNS
cord-290218-dvyeg5fk	38	16	at	at	IN
cord-290218-dvyeg5fk	38	17	the	the	DT
cord-290218-dvyeg5fk	38	18	extended	extended	JJ
cord-290218-dvyeg5fk	38	19	N	n	CD
cord-290218-dvyeg5fk	38	20	-	-	HYPH
cord-290218-dvyeg5fk	38	21	terminal	terminal	NN
cord-290218-dvyeg5fk	38	22	of	of	IN
cord-290218-dvyeg5fk	38	23	nsp8	nsp8	NN
cord-290218-dvyeg5fk	38	24	and	and	CC
cord-290218-dvyeg5fk	38	25	bases	basis	NNS
cord-290218-dvyeg5fk	38	26	in	in	IN
cord-290218-dvyeg5fk	38	27	RNA	RNA	NNP
cord-290218-dvyeg5fk	38	28	backbones	backbone	NNS
cord-290218-dvyeg5fk	38	29	(	(	-LRB-
cord-290218-dvyeg5fk	38	30	Fig	Fig	NNP
cord-290218-dvyeg5fk	38	31	.	.	.
cord-290218-dvyeg5fk	38	32	3E	3E	NNP
cord-290218-dvyeg5fk	38	33	)	)	-RRB-
cord-290218-dvyeg5fk	38	34	and	and	CC
cord-290218-dvyeg5fk	38	35	reported	report	VBD
cord-290218-dvyeg5fk	38	36	to	to	TO
cord-290218-dvyeg5fk	38	37	account	account	VB
cord-290218-dvyeg5fk	38	38	for	for	IN
cord-290218-dvyeg5fk	38	39	the	the	DT
cord-290218-dvyeg5fk	38	40	known	know	VBN
cord-290218-dvyeg5fk	38	41	processivity	processivity	NN
cord-290218-dvyeg5fk	38	42	of	of	IN
cord-290218-dvyeg5fk	38	43	the	the	DT
cord-290218-dvyeg5fk	38	44	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	38	45	,	,	,
cord-290218-dvyeg5fk	38	46	which	which	WDT
cord-290218-dvyeg5fk	38	47	is	be	VBZ
cord-290218-dvyeg5fk	38	48	required	require	VBN
cord-290218-dvyeg5fk	38	49	for	for	IN
cord-290218-dvyeg5fk	38	50	replicating	replicate	VBG
cord-290218-dvyeg5fk	38	51	the	the	DT
cord-290218-dvyeg5fk	38	52	long	long	JJ
cord-290218-dvyeg5fk	38	53	coronavirus	coronavirus	NN
cord-290218-dvyeg5fk	38	54	genomes	genome	NNS
cord-290218-dvyeg5fk	38	55	[	[	-LRB-
cord-290218-dvyeg5fk	38	56	39	39	CD
cord-290218-dvyeg5fk	38	57	]	]	-RRB-
cord-290218-dvyeg5fk	38	58	.	.	.
cord-290218-dvyeg5fk	39	1	In	in	IN
cord-290218-dvyeg5fk	39	2	this	this	DT
cord-290218-dvyeg5fk	39	3	structure	structure	NN
cord-290218-dvyeg5fk	39	4	of	of	IN
cord-290218-dvyeg5fk	39	5	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	39	6	in	in	IN
cord-290218-dvyeg5fk	39	7	complex	complex	NN
cord-290218-dvyeg5fk	39	8	with	with	IN
cord-290218-dvyeg5fk	39	9	the	the	DT
cord-290218-dvyeg5fk	39	10	protruding	protrude	VBG
cord-290218-dvyeg5fk	39	11	RNA	RNA	NNP
cord-290218-dvyeg5fk	39	12	,	,	,
cord-290218-dvyeg5fk	39	13	the	the	DT
cord-290218-dvyeg5fk	39	14	prominent	prominent	JJ
cord-290218-dvyeg5fk	39	15	nsp8	nsp8	NNP
cord-290218-dvyeg5fk	39	16	-	-	HYPH
cord-290218-dvyeg5fk	39	17	2	2	CD
cord-290218-dvyeg5fk	39	18	extends	extend	VBZ
cord-290218-dvyeg5fk	39	19	up	up	IN
cord-290218-dvyeg5fk	39	20	to	to	TO
cord-290218-dvyeg5fk	39	21	28	28	CD
cord-290218-dvyeg5fk	39	22	base	base	NN
cord-290218-dvyeg5fk	39	23	pairs	pair	NNS
cord-290218-dvyeg5fk	39	24	away	away	RB
cord-290218-dvyeg5fk	39	25	from	from	IN
cord-290218-dvyeg5fk	39	26	the	the	DT
cord-290218-dvyeg5fk	39	27	active	active	JJ
cord-290218-dvyeg5fk	39	28	site	site	NN
cord-290218-dvyeg5fk	39	29	,	,	,
cord-290218-dvyeg5fk	39	30	which	which	WDT
cord-290218-dvyeg5fk	39	31	is	be	VBZ
cord-290218-dvyeg5fk	39	32	a	a	DT
cord-290218-dvyeg5fk	39	33	unique	unique	JJ
cord-290218-dvyeg5fk	39	34	conformation	conformation	NN
cord-290218-dvyeg5fk	39	35	not	not	RB
cord-290218-dvyeg5fk	39	36	observed	observe	VBN
cord-290218-dvyeg5fk	39	37	in	in	IN
cord-290218-dvyeg5fk	39	38	structures	structure	NNS
cord-290218-dvyeg5fk	39	39	of	of	IN
cord-290218-dvyeg5fk	39	40	other	other	JJ
cord-290218-dvyeg5fk	39	41	RNA	RNA	NNP
cord-290218-dvyeg5fk	39	42	viruses	virus	NNS
cord-290218-dvyeg5fk	39	43	[	[	-LRB-
cord-290218-dvyeg5fk	39	44	33	33	CD
cord-290218-dvyeg5fk	39	45	,	,	,
cord-290218-dvyeg5fk	39	46	34	34	CD
cord-290218-dvyeg5fk	39	47	]	]	-RRB-
cord-290218-dvyeg5fk	39	48	and	and	CC
cord-290218-dvyeg5fk	39	49	SARS	SARS	NNP
cord-290218-dvyeg5fk	39	50	-	-	HYPH
cord-290218-dvyeg5fk	39	51	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	39	52	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	39	53	-	-	HYPH
cord-290218-dvyeg5fk	39	54	RNA	RNA	NNP
cord-290218-dvyeg5fk	39	55	complexes	complex	NNS
cord-290218-dvyeg5fk	39	56	[	[	-LRB-
cord-290218-dvyeg5fk	39	57	17	17	CD
cord-290218-dvyeg5fk	39	58	,	,	,
cord-290218-dvyeg5fk	39	59	19	19	CD
cord-290218-dvyeg5fk	39	60	]	]	-RRB-
cord-290218-dvyeg5fk	39	61	.	.	.
cord-290218-dvyeg5fk	40	1	The	the	DT
cord-290218-dvyeg5fk	40	2	N	n	CD
cord-290218-dvyeg5fk	40	3	-	-	HYPH
cord-290218-dvyeg5fk	40	4	terminal	terminal	NN
cord-290218-dvyeg5fk	40	5	ends	end	NNS
cord-290218-dvyeg5fk	40	6	of	of	IN
cord-290218-dvyeg5fk	40	7	two	two	CD
cord-290218-dvyeg5fk	40	8	copies	copy	NNS
cord-290218-dvyeg5fk	40	9	of	of	IN
cord-290218-dvyeg5fk	40	10	nsp8	nsp8	NN
cord-290218-dvyeg5fk	40	11	direct	direct	JJ
cord-290218-dvyeg5fk	40	12	to	to	IN
cord-290218-dvyeg5fk	40	13	different	different	JJ
cord-290218-dvyeg5fk	40	14	orientations	orientation	NNS
cord-290218-dvyeg5fk	40	15	,	,	,
cord-290218-dvyeg5fk	40	16	which	which	WDT
cord-290218-dvyeg5fk	40	17	synergistically	synergistically	RB
cord-290218-dvyeg5fk	40	18	prevent	prevent	VBP
cord-290218-dvyeg5fk	40	19	premature	premature	JJ
cord-290218-dvyeg5fk	40	20	dissociation	dissociation	NN
cord-290218-dvyeg5fk	40	21	of	of	IN
cord-290218-dvyeg5fk	40	22	helical	helical	JJ
cord-290218-dvyeg5fk	40	23	RNA	RNA	NNP
cord-290218-dvyeg5fk	40	24	from	from	IN
cord-290218-dvyeg5fk	40	25	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	41	1	(	(	-LRB-
cord-290218-dvyeg5fk	41	2	Fig	Fig	NNP
cord-290218-dvyeg5fk	41	3	.	.	.
cord-290218-dvyeg5fk	41	4	3D	3D	NNP
cord-290218-dvyeg5fk	41	5	and	and	CC
cord-290218-dvyeg5fk	41	6	E	E	NNP
cord-290218-dvyeg5fk	41	7	)	)	-RRB-
cord-290218-dvyeg5fk	41	8	.	.	.
cord-290218-dvyeg5fk	42	1	Similarly	similarly	RB
cord-290218-dvyeg5fk	42	2	,	,	,
cord-290218-dvyeg5fk	42	3	a	a	DT
cord-290218-dvyeg5fk	42	4	pre	pre	JJ
cord-290218-dvyeg5fk	42	5	-	-	JJ
cord-290218-dvyeg5fk	42	6	released	release	VBN
cord-290218-dvyeg5fk	42	7	structure	structure	NN
cord-290218-dvyeg5fk	42	8	of	of	IN
cord-290218-dvyeg5fk	42	9	helicase	helicase	NN
cord-290218-dvyeg5fk	42	10	-	-	HYPH
cord-290218-dvyeg5fk	42	11	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	42	12	-	-	HYPH
cord-290218-dvyeg5fk	42	13	RNA	RNA	NNP
cord-290218-dvyeg5fk	42	14	complex	complex	NN
cord-290218-dvyeg5fk	42	15	also	also	RB
cord-290218-dvyeg5fk	42	16	exhibits	exhibit	VBZ
cord-290218-dvyeg5fk	42	17	a	a	DT
cord-290218-dvyeg5fk	42	18	similar	similar	JJ
cord-290218-dvyeg5fk	42	19	nsp8	nsp8	JJ
cord-290218-dvyeg5fk	42	20	conformation	conformation	NN
cord-290218-dvyeg5fk	42	21	[	[	-LRB-
cord-290218-dvyeg5fk	42	22	40	40	CD
cord-290218-dvyeg5fk	42	23	]	]	-RRB-
cord-290218-dvyeg5fk	42	24	,	,	,
cord-290218-dvyeg5fk	42	25	while	while	IN
cord-290218-dvyeg5fk	42	26	structure	structure	NN
cord-290218-dvyeg5fk	42	27	of	of	IN
cord-290218-dvyeg5fk	42	28	pre	pre	JJ
cord-290218-dvyeg5fk	42	29	-	-	JJ
cord-290218-dvyeg5fk	42	30	translocated	translocated	JJ
cord-290218-dvyeg5fk	42	31	SARS	SARS	NNP
cord-290218-dvyeg5fk	42	32	-	-	HYPH
cord-290218-dvyeg5fk	42	33	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	42	34	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	42	35	-	-	HYPH
cord-290218-dvyeg5fk	42	36	RNA	RNA	NNP
cord-290218-dvyeg5fk	42	37	complex	complex	NN
cord-290218-dvyeg5fk	42	38	exhibits	exhibit	VBZ
cord-290218-dvyeg5fk	42	39	two	two	CD
cord-290218-dvyeg5fk	42	40	conformations	conformation	NNS
cord-290218-dvyeg5fk	42	41	of	of	IN
cord-290218-dvyeg5fk	42	42	nsp8	nsp8	NN
cord-290218-dvyeg5fk	42	43	-	-	HYPH
cord-290218-dvyeg5fk	42	44	2	2	CD
cord-290218-dvyeg5fk	42	45	with	with	IN
cord-290218-dvyeg5fk	42	46	a	a	DT
cord-290218-dvyeg5fk	42	47	~45º	~45º	ADD
cord-290218-dvyeg5fk	42	48	rotation	rotation	NN
cord-290218-dvyeg5fk	42	49	at	at	IN
cord-290218-dvyeg5fk	42	50	its	-PRON-	PRP$
cord-290218-dvyeg5fk	42	51	N	n	CD
cord-290218-dvyeg5fk	42	52	-	-	HYPH
cord-290218-dvyeg5fk	42	53	terminus	terminus	NN
cord-290218-dvyeg5fk	42	54	,	,	,
cord-290218-dvyeg5fk	42	55	one	one	CD
cord-290218-dvyeg5fk	42	56	of	of	IN
cord-290218-dvyeg5fk	42	57	which	which	WDT
cord-290218-dvyeg5fk	42	58	structurally	structurally	RB
cord-290218-dvyeg5fk	42	59	overlaps	overlap	VBZ
cord-290218-dvyeg5fk	42	60	with	with	IN
cord-290218-dvyeg5fk	42	61	the	the	DT
cord-290218-dvyeg5fk	42	62	"	"	``
cord-290218-dvyeg5fk	42	63	sliding	slide	VBG
cord-290218-dvyeg5fk	42	64	poles"-like	poles"-like	NN
cord-290218-dvyeg5fk	42	65	conformation	conformation	NN
cord-290218-dvyeg5fk	42	66	of	of	IN
cord-290218-dvyeg5fk	42	67	nsp8	nsp8	NN
cord-290218-dvyeg5fk	42	68	-	-	HYPH
cord-290218-dvyeg5fk	42	69	2	2	CD
cord-290218-dvyeg5fk	42	70	[	[	-LRB-
cord-290218-dvyeg5fk	42	71	18	18	CD
cord-290218-dvyeg5fk	42	72	]	]	-RRB-
cord-290218-dvyeg5fk	42	73	.	.	.
cord-290218-dvyeg5fk	43	1	The	the	DT
cord-290218-dvyeg5fk	43	2	alanine	alanine	JJ
cord-290218-dvyeg5fk	43	3	mutation	mutation	NN
cord-290218-dvyeg5fk	43	4	of	of	IN
cord-290218-dvyeg5fk	43	5	K58	K58	NNP
cord-290218-dvyeg5fk	43	6	,	,	,
cord-290218-dvyeg5fk	43	7	which	which	WDT
cord-290218-dvyeg5fk	43	8	located	locate	VBN
cord-290218-dvyeg5fk	43	9	in	in	IN
cord-290218-dvyeg5fk	43	10	the	the	DT
cord-290218-dvyeg5fk	43	11	nsp8	nsp8	JJ
cord-290218-dvyeg5fk	43	12	extension	extension	NN
cord-290218-dvyeg5fk	43	13	,	,	,
cord-290218-dvyeg5fk	43	14	is	be	VBZ
cord-290218-dvyeg5fk	43	15	lethal	lethal	JJ
cord-290218-dvyeg5fk	43	16	to	to	IN
cord-290218-dvyeg5fk	43	17	the	the	DT
cord-290218-dvyeg5fk	43	18	virus	virus	NN
cord-290218-dvyeg5fk	43	19	,	,	,
cord-290218-dvyeg5fk	43	20	supporting	support	VBG
cord-290218-dvyeg5fk	43	21	the	the	DT
cord-290218-dvyeg5fk	43	22	model	model	NN
cord-290218-dvyeg5fk	43	23	of	of	IN
cord-290218-dvyeg5fk	43	24	"	"	``
cord-290218-dvyeg5fk	43	25	sliding	slide	VBG
cord-290218-dvyeg5fk	43	26	poles	pole	NNS
cord-290218-dvyeg5fk	43	27	"	"	''
cord-290218-dvyeg5fk	43	28	[	[	-LRB-
cord-290218-dvyeg5fk	43	29	26	26	CD
cord-290218-dvyeg5fk	43	30	]	]	-RRB-
cord-290218-dvyeg5fk	43	31	.	.	.
cord-290218-dvyeg5fk	44	1	Collectively	collectively	RB
cord-290218-dvyeg5fk	44	2	,	,	,
cord-290218-dvyeg5fk	44	3	these	these	DT
cord-290218-dvyeg5fk	44	4	findings	finding	NNS
cord-290218-dvyeg5fk	44	5	indicate	indicate	VBP
cord-290218-dvyeg5fk	44	6	that	that	IN
cord-290218-dvyeg5fk	44	7	the	the	DT
cord-290218-dvyeg5fk	44	8	N	n	CD
cord-290218-dvyeg5fk	44	9	-	-	HYPH
cord-290218-dvyeg5fk	44	10	terminal	terminal	NN
cord-290218-dvyeg5fk	44	11	conformation	conformation	NN
cord-290218-dvyeg5fk	44	12	of	of	IN
cord-290218-dvyeg5fk	44	13	nsp8	nsp8	NN
cord-290218-dvyeg5fk	44	14	is	be	VBZ
cord-290218-dvyeg5fk	44	15	flexible	flexible	JJ
cord-290218-dvyeg5fk	44	16	in	in	IN
cord-290218-dvyeg5fk	44	17	solution	solution	NN
cord-290218-dvyeg5fk	44	18	and	and	CC
cord-290218-dvyeg5fk	44	19	dominates	dominate	VBZ
cord-290218-dvyeg5fk	44	20	the	the	DT
cord-290218-dvyeg5fk	44	21	"	"	``
cord-290218-dvyeg5fk	44	22	sliding	slide	VBG
cord-290218-dvyeg5fk	44	23	pole"-like	pole"-like	JJ
cord-290218-dvyeg5fk	44	24	state	state	NN
cord-290218-dvyeg5fk	44	25	during	during	IN
cord-290218-dvyeg5fk	44	26	RNA	RNA	NNP
cord-290218-dvyeg5fk	44	27	elongation	elongation	NN
cord-290218-dvyeg5fk	44	28	.	.	.
cord-290218-dvyeg5fk	45	1	Although	although	IN
cord-290218-dvyeg5fk	45	2	the	the	DT
cord-290218-dvyeg5fk	45	3	sequence	sequence	NN
cord-290218-dvyeg5fk	45	4	identity	identity	NN
cord-290218-dvyeg5fk	45	5	of	of	IN
cord-290218-dvyeg5fk	45	6	nsp12	nsp12	CD
cord-290218-dvyeg5fk	45	7	across	across	IN
cord-290218-dvyeg5fk	45	8	the	the	DT
cord-290218-dvyeg5fk	45	9	RNA	RNA	NNP
cord-290218-dvyeg5fk	45	10	viruses	virus	NNS
cord-290218-dvyeg5fk	45	11	is	be	VBZ
cord-290218-dvyeg5fk	45	12	low	low	JJ
cord-290218-dvyeg5fk	45	13	,	,	,
cord-290218-dvyeg5fk	45	14	the	the	DT
cord-290218-dvyeg5fk	45	15	polymerase	polymerase	NN
cord-290218-dvyeg5fk	45	16	active	active	JJ
cord-290218-dvyeg5fk	45	17	site	site	NN
cord-290218-dvyeg5fk	45	18	is	be	VBZ
cord-290218-dvyeg5fk	45	19	structurally	structurally	RB
cord-290218-dvyeg5fk	45	20	highly	highly	RB
cord-290218-dvyeg5fk	45	21	conserved	conserve	VBN
cord-290218-dvyeg5fk	45	22	,	,	,
cord-290218-dvyeg5fk	45	23	suggesting	suggest	VBG
cord-290218-dvyeg5fk	45	24	that	that	IN
cord-290218-dvyeg5fk	45	25	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	45	26	inhibitors	inhibitor	NNS
cord-290218-dvyeg5fk	45	27	may	may	MD
cord-290218-dvyeg5fk	45	28	serve	serve	VB
cord-290218-dvyeg5fk	45	29	as	as	IN
cord-290218-dvyeg5fk	45	30	a	a	DT
cord-290218-dvyeg5fk	45	31	potential	potential	JJ
cord-290218-dvyeg5fk	45	32	J	J	NNP
cord-290218-dvyeg5fk	45	33	o	o	NN
cord-290218-dvyeg5fk	45	34	u	u	NN
cord-290218-dvyeg5fk	45	35	r	r	NN
cord-290218-dvyeg5fk	45	36	n	n	NN
cord-290218-dvyeg5fk	45	37	a	a	DT
cord-290218-dvyeg5fk	45	38	l	l	NN
cord-290218-dvyeg5fk	45	39	P	p	NN
cord-290218-dvyeg5fk	45	40	r	r	NN
cord-290218-dvyeg5fk	45	41	e	e	NN
cord-290218-dvyeg5fk	45	42	-p	-p	NN
cord-290218-dvyeg5fk	45	43	r	r	NN
cord-290218-dvyeg5fk	45	44	o	o	NN
cord-290218-dvyeg5fk	45	45	o	o	NN
cord-290218-dvyeg5fk	45	46	f	f	NN
cord-290218-dvyeg5fk	45	47	broad	broad	JJ
cord-290218-dvyeg5fk	45	48	-	-	HYPH
cord-290218-dvyeg5fk	45	49	spectrum	spectrum	NN
cord-290218-dvyeg5fk	45	50	antiviral	antiviral	JJ
cord-290218-dvyeg5fk	45	51	drug	drug	NN
cord-290218-dvyeg5fk	45	52	against	against	IN
cord-290218-dvyeg5fk	45	53	RNA	RNA	NNP
cord-290218-dvyeg5fk	45	54	viruses	virus	NNS
cord-290218-dvyeg5fk	45	55	.	.	.
cord-290218-dvyeg5fk	46	1	Remdesivir	Remdesivir	NNP
cord-290218-dvyeg5fk	46	2	(	(	-LRB-
cord-290218-dvyeg5fk	46	3	RDV	RDV	NNP
cord-290218-dvyeg5fk	46	4	,	,	,
cord-290218-dvyeg5fk	46	5	GS-5734	GS-5734	NNP
cord-290218-dvyeg5fk	46	6	)	)	-RRB-
cord-290218-dvyeg5fk	46	7	is	be	VBZ
cord-290218-dvyeg5fk	46	8	a	a	DT
cord-290218-dvyeg5fk	46	9	1'-cyano	1'-cyano	CD
cord-290218-dvyeg5fk	46	10	-	-	HYPH
cord-290218-dvyeg5fk	46	11	substituted	substitute	VBN
cord-290218-dvyeg5fk	46	12	adenosine	adenosine	NN
cord-290218-dvyeg5fk	46	13	nucleotide	nucleotide	JJ
cord-290218-dvyeg5fk	46	14	analog	analog	NN
cord-290218-dvyeg5fk	46	15	prodrug	prodrug	NN
cord-290218-dvyeg5fk	46	16	,	,	,
cord-290218-dvyeg5fk	46	17	which	which	WDT
cord-290218-dvyeg5fk	46	18	is	be	VBZ
cord-290218-dvyeg5fk	46	19	originally	originally	RB
cord-290218-dvyeg5fk	46	20	developed	develop	VBN
cord-290218-dvyeg5fk	46	21	as	as	IN
cord-290218-dvyeg5fk	46	22	a	a	DT
cord-290218-dvyeg5fk	46	23	treatment	treatment	NN
cord-290218-dvyeg5fk	46	24	for	for	IN
cord-290218-dvyeg5fk	46	25	the	the	DT
cord-290218-dvyeg5fk	46	26	Ebola	Ebola	NNP
cord-290218-dvyeg5fk	46	27	virus	virus	NN
cord-290218-dvyeg5fk	46	28	by	by	IN
cord-290218-dvyeg5fk	46	29	inhibiting	inhibit	VBG
cord-290218-dvyeg5fk	46	30	RNA	RNA	NNP
cord-290218-dvyeg5fk	46	31	synthesis	synthesis	NN
cord-290218-dvyeg5fk	46	32	.	.	.
cord-290218-dvyeg5fk	47	1	It	-PRON-	PRP
cord-290218-dvyeg5fk	47	2	is	be	VBZ
cord-290218-dvyeg5fk	47	3	metabolized	metabolize	VBN
cord-290218-dvyeg5fk	47	4	into	into	IN
cord-290218-dvyeg5fk	47	5	its	-PRON-	PRP$
cord-290218-dvyeg5fk	47	6	active	active	JJ
cord-290218-dvyeg5fk	47	7	form	form	NN
cord-290218-dvyeg5fk	47	8	(	(	-LRB-
cord-290218-dvyeg5fk	47	9	RDV	RDV	NNP
cord-290218-dvyeg5fk	47	10	-	-	HYPH
cord-290218-dvyeg5fk	47	11	MP	MP	NNP
cord-290218-dvyeg5fk	47	12	,	,	,
cord-290218-dvyeg5fk	47	13	GS-441524-MP	GS-441524-MP	NNP
cord-290218-dvyeg5fk	47	14	)	)	-RRB-
cord-290218-dvyeg5fk	47	15	,	,	,
cord-290218-dvyeg5fk	47	16	which	which	WDT
cord-290218-dvyeg5fk	47	17	has	have	VBZ
cord-290218-dvyeg5fk	47	18	a	a	DT
cord-290218-dvyeg5fk	47	19	monophosphate	monophosphate	NN
cord-290218-dvyeg5fk	47	20	moiety	moiety	NN
cord-290218-dvyeg5fk	47	21	to	to	TO
cord-290218-dvyeg5fk	47	22	enhance	enhance	VB
cord-290218-dvyeg5fk	47	23	intracellular	intracellular	JJ
cord-290218-dvyeg5fk	47	24	metabolism	metabolism	NN
cord-290218-dvyeg5fk	47	25	into	into	IN
cord-290218-dvyeg5fk	47	26	its	-PRON-	PRP$
cord-290218-dvyeg5fk	47	27	active	active	JJ
cord-290218-dvyeg5fk	47	28	triphosphate	triphosphate	NN
cord-290218-dvyeg5fk	47	29	metabolite	metabolite	NN
cord-290218-dvyeg5fk	47	30	(	(	-LRB-
cord-290218-dvyeg5fk	47	31	RDV	RDV	NNP
cord-290218-dvyeg5fk	47	32	-	-	HYPH
cord-290218-dvyeg5fk	47	33	TP	TP	NNP
cord-290218-dvyeg5fk	47	34	)	)	-RRB-
cord-290218-dvyeg5fk	48	1	(	(	-LRB-
cord-290218-dvyeg5fk	48	2	Fig	Fig	NNP
cord-290218-dvyeg5fk	48	3	.	.	.
cord-290218-dvyeg5fk	48	4	4A	4a	CD
cord-290218-dvyeg5fk	48	5	)	)	-RRB-
cord-290218-dvyeg5fk	49	1	[	[	-LRB-
cord-290218-dvyeg5fk	49	2	41	41	CD
cord-290218-dvyeg5fk	49	3	]	]	-RRB-
cord-290218-dvyeg5fk	49	4	.	.	.
cord-290218-dvyeg5fk	50	1	Like	like	IN
cord-290218-dvyeg5fk	50	2	many	many	JJ
cord-290218-dvyeg5fk	50	3	nucleotide	nucleotide	JJ
cord-290218-dvyeg5fk	50	4	analog	analog	NN
cord-290218-dvyeg5fk	50	5	inhibitors	inhibitor	NNS
cord-290218-dvyeg5fk	50	6	,	,	,
cord-290218-dvyeg5fk	50	7	RDV	RDV	NNP
cord-290218-dvyeg5fk	50	8	-	-	HYPH
cord-290218-dvyeg5fk	50	9	TP	TP	NNP
cord-290218-dvyeg5fk	50	10	competes	compete	VBZ
cord-290218-dvyeg5fk	50	11	with	with	IN
cord-290218-dvyeg5fk	50	12	the	the	DT
cord-290218-dvyeg5fk	50	13	incorporation	incorporation	NN
cord-290218-dvyeg5fk	50	14	of	of	IN
cord-290218-dvyeg5fk	50	15	nucleotide	nucleotide	JJ
cord-290218-dvyeg5fk	50	16	counterparts	counterpart	NNS
cord-290218-dvyeg5fk	50	17	and	and	CC
cord-290218-dvyeg5fk	50	18	inhibits	inhibit	VBZ
cord-290218-dvyeg5fk	50	19	transcription	transcription	NN
cord-290218-dvyeg5fk	50	20	of	of	IN
cord-290218-dvyeg5fk	50	21	viral	viral	JJ
cord-290218-dvyeg5fk	50	22	RNA	RNA	NNP
cord-290218-dvyeg5fk	50	23	.	.	.
cord-290218-dvyeg5fk	51	1	The	the	DT
cord-290218-dvyeg5fk	51	2	structure	structure	NN
cord-290218-dvyeg5fk	51	3	of	of	IN
cord-290218-dvyeg5fk	51	4	the	the	DT
cord-290218-dvyeg5fk	51	5	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	51	6	-	-	HYPH
cord-290218-dvyeg5fk	51	7	RNA	RNA	NNP
cord-290218-dvyeg5fk	51	8	-	-	HYPH
cord-290218-dvyeg5fk	51	9	RDV	RDV	NNP
cord-290218-dvyeg5fk	51	10	complex	complex	NN
cord-290218-dvyeg5fk	51	11	reveals	reveal	VBZ
cord-290218-dvyeg5fk	51	12	a	a	DT
cord-290218-dvyeg5fk	51	13	molecular	molecular	JJ
cord-290218-dvyeg5fk	51	14	mechanism	mechanism	NN
cord-290218-dvyeg5fk	51	15	for	for	IN
cord-290218-dvyeg5fk	51	16	transcription	transcription	NN
cord-290218-dvyeg5fk	51	17	inhibition	inhibition	NN
cord-290218-dvyeg5fk	51	18	by	by	IN
cord-290218-dvyeg5fk	51	19	remdesivir	remdesivir	NNP
cord-290218-dvyeg5fk	51	20	[	[	-LRB-
cord-290218-dvyeg5fk	51	21	17	17	CD
cord-290218-dvyeg5fk	51	22	]	]	-RRB-
cord-290218-dvyeg5fk	51	23	.	.	.
cord-290218-dvyeg5fk	52	1	Only	only	RB
cord-290218-dvyeg5fk	52	2	one	one	CD
cord-290218-dvyeg5fk	52	3	RDV	RDV	NNP
cord-290218-dvyeg5fk	52	4	-	-	HYPH
cord-290218-dvyeg5fk	52	5	MP	MP	NNP
cord-290218-dvyeg5fk	52	6	molecule	molecule	NN
cord-290218-dvyeg5fk	52	7	incorporates	incorporate	VBZ
cord-290218-dvyeg5fk	52	8	into	into	IN
cord-290218-dvyeg5fk	52	9	the	the	DT
cord-290218-dvyeg5fk	52	10	primer	primer	NN
cord-290218-dvyeg5fk	52	11	strand	strand	NN
cord-290218-dvyeg5fk	52	12	at	at	IN
cord-290218-dvyeg5fk	52	13	+1	+1	HYPH
cord-290218-dvyeg5fk	52	14	position	position	NN
cord-290218-dvyeg5fk	52	15	and	and	CC
cord-290218-dvyeg5fk	52	16	forms	form	NNS
cord-290218-dvyeg5fk	52	17	base	base	NN
cord-290218-dvyeg5fk	52	18	-	-	HYPH
cord-290218-dvyeg5fk	52	19	stacking	stack	VBG
cord-290218-dvyeg5fk	52	20	interaction	interaction	NN
cord-290218-dvyeg5fk	52	21	with	with	IN
cord-290218-dvyeg5fk	52	22	bases	basis	NNS
cord-290218-dvyeg5fk	52	23	in	in	IN
cord-290218-dvyeg5fk	52	24	primer	primer	NN
cord-290218-dvyeg5fk	52	25	strand	strand	NN
cord-290218-dvyeg5fk	52	26	and	and	CC
cord-290218-dvyeg5fk	52	27	two	two	CD
cord-290218-dvyeg5fk	52	28	hydrogen	hydrogen	NN
cord-290218-dvyeg5fk	52	29	bonds	bond	NNS
cord-290218-dvyeg5fk	52	30	with	with	IN
cord-290218-dvyeg5fk	52	31	the	the	DT
cord-290218-dvyeg5fk	52	32	uridine	uridine	JJ
cord-290218-dvyeg5fk	52	33	base	base	NN
cord-290218-dvyeg5fk	52	34	from	from	IN
cord-290218-dvyeg5fk	52	35	the	the	DT
cord-290218-dvyeg5fk	52	36	template	template	NN
cord-290218-dvyeg5fk	52	37	strand	strand	NN
cord-290218-dvyeg5fk	52	38	.	.	.
cord-290218-dvyeg5fk	53	1	RDV	RDV	NNP
cord-290218-dvyeg5fk	53	2	-	-	HYPH
cord-290218-dvyeg5fk	53	3	MP	MP	NNP
cord-290218-dvyeg5fk	53	4	also	also	RB
cord-290218-dvyeg5fk	53	5	interacts	interact	VBZ
cord-290218-dvyeg5fk	53	6	with	with	IN
cord-290218-dvyeg5fk	53	7	residues	residue	NNS
cord-290218-dvyeg5fk	53	8	K545	K545	NNP
cord-290218-dvyeg5fk	53	9	and	and	CC
cord-290218-dvyeg5fk	53	10	R555	R555	NNP
cord-290218-dvyeg5fk	53	11	in	in	IN
cord-290218-dvyeg5fk	53	12	motif	motif	NN
cord-290218-dvyeg5fk	54	1	F.	F.	NNP
cord-290218-dvyeg5fk	54	2	Near	Near	NNP
cord-290218-dvyeg5fk	54	3	RDV	RDV	NNP
cord-290218-dvyeg5fk	54	4	-	-	HYPH
cord-290218-dvyeg5fk	54	5	MP	MP	NNP
cord-290218-dvyeg5fk	54	6	are	be	VBP
cord-290218-dvyeg5fk	54	7	two	two	CD
cord-290218-dvyeg5fk	54	8	magnesium	magnesium	NN
cord-290218-dvyeg5fk	54	9	ions	ion	NNS
cord-290218-dvyeg5fk	54	10	and	and	CC
cord-290218-dvyeg5fk	54	11	pyrophosphate	pyrophosphate	NN
cord-290218-dvyeg5fk	54	12	,	,	,
cord-290218-dvyeg5fk	54	13	whose	whose	WP$
cord-290218-dvyeg5fk	54	14	densities	density	NNS
cord-290218-dvyeg5fk	54	15	are	be	VBP
cord-290218-dvyeg5fk	54	16	missing	miss	VBG
cord-290218-dvyeg5fk	54	17	in	in	IN
cord-290218-dvyeg5fk	54	18	other	other	JJ
cord-290218-dvyeg5fk	54	19	structures	structure	NNS
cord-290218-dvyeg5fk	54	20	of	of	IN
cord-290218-dvyeg5fk	54	21	SARS	SARS	NNP
cord-290218-dvyeg5fk	54	22	-	-	HYPH
cord-290218-dvyeg5fk	54	23	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	54	24	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	54	25	-	-	HYPH
cord-290218-dvyeg5fk	54	26	RNA	RNA	NNP
cord-290218-dvyeg5fk	54	27	complexes	complex	NNS
cord-290218-dvyeg5fk	54	28	.	.	.
cord-290218-dvyeg5fk	55	1	The	the	DT
cord-290218-dvyeg5fk	55	2	pyrophosphate	pyrophosphate	NN
cord-290218-dvyeg5fk	55	3	may	may	MD
cord-290218-dvyeg5fk	55	4	block	block	VB
cord-290218-dvyeg5fk	55	5	the	the	DT
cord-290218-dvyeg5fk	55	6	entry	entry	NN
cord-290218-dvyeg5fk	55	7	of	of	IN
cord-290218-dvyeg5fk	55	8	NTP	NTP	NNP
cord-290218-dvyeg5fk	55	9	to	to	IN
cord-290218-dvyeg5fk	55	10	the	the	DT
cord-290218-dvyeg5fk	55	11	active	active	JJ
cord-290218-dvyeg5fk	55	12	site	site	NN
cord-290218-dvyeg5fk	55	13	by	by	IN
cord-290218-dvyeg5fk	55	14	occupying	occupy	VBG
cord-290218-dvyeg5fk	55	15	the	the	DT
cord-290218-dvyeg5fk	55	16	entrance	entrance	NN
cord-290218-dvyeg5fk	55	17	of	of	IN
cord-290218-dvyeg5fk	55	18	nucleotides	nucleotide	NNS
cord-290218-dvyeg5fk	55	19	.	.	.
cord-290218-dvyeg5fk	56	1	Two	two	CD
cord-290218-dvyeg5fk	56	2	magnesium	magnesium	NN
cord-290218-dvyeg5fk	56	3	ions	ion	NNS
cord-290218-dvyeg5fk	56	4	contact	contact	VBP
cord-290218-dvyeg5fk	56	5	with	with	IN
cord-290218-dvyeg5fk	56	6	phosphate	phosphate	NN
cord-290218-dvyeg5fk	56	7	diester	diester	NN
cord-290218-dvyeg5fk	56	8	backbone	backbone	NN
cord-290218-dvyeg5fk	56	9	and	and	CC
cord-290218-dvyeg5fk	56	10	form	form	VB
cord-290218-dvyeg5fk	56	11	polar	polar	JJ
cord-290218-dvyeg5fk	56	12	interactions	interaction	NNS
cord-290218-dvyeg5fk	56	13	with	with	IN
cord-290218-dvyeg5fk	56	14	two	two	CD
cord-290218-dvyeg5fk	56	15	conserved	conserved	JJ
cord-290218-dvyeg5fk	56	16	aspartic	aspartic	JJ
cord-290218-dvyeg5fk	56	17	acids	acid	NNS
cord-290218-dvyeg5fk	56	18	in	in	IN
cord-290218-dvyeg5fk	56	19	motif	motif	NN
cord-290218-dvyeg5fk	56	20	C	c	NN
cord-290218-dvyeg5fk	56	21	(	(	-LRB-
cord-290218-dvyeg5fk	56	22	Fig	Fig	NNP
cord-290218-dvyeg5fk	56	23	.	.	.
cord-290218-dvyeg5fk	56	24	4B	4b	CD
cord-290218-dvyeg5fk	56	25	)	)	-RRB-
cord-290218-dvyeg5fk	56	26	.	.	.
cord-290218-dvyeg5fk	57	1	In	in	IN
cord-290218-dvyeg5fk	57	2	contrast	contrast	NN
cord-290218-dvyeg5fk	57	3	to	to	IN
cord-290218-dvyeg5fk	57	4	other	other	JJ
cord-290218-dvyeg5fk	57	5	classic	classic	JJ
cord-290218-dvyeg5fk	57	6	chain	chain	NN
cord-290218-dvyeg5fk	57	7	terminators	terminator	NNS
cord-290218-dvyeg5fk	57	8	,	,	,
cord-290218-dvyeg5fk	57	9	the	the	DT
cord-290218-dvyeg5fk	57	10	featured	feature	VBN
cord-290218-dvyeg5fk	57	11	inhibition	inhibition	NN
cord-290218-dvyeg5fk	57	12	mechanism	mechanism	NN
cord-290218-dvyeg5fk	57	13	of	of	IN
cord-290218-dvyeg5fk	57	14	remdesivir	remdesivir	NNP
cord-290218-dvyeg5fk	57	15	is	be	VBZ
cord-290218-dvyeg5fk	57	16	a	a	DT
cord-290218-dvyeg5fk	57	17	delayed	delay	VBN
cord-290218-dvyeg5fk	57	18	chain	chain	NN
cord-290218-dvyeg5fk	57	19	termination	termination	NN
cord-290218-dvyeg5fk	57	20	of	of	IN
cord-290218-dvyeg5fk	57	21	nascent	nascent	JJ
cord-290218-dvyeg5fk	57	22	viral	viral	JJ
cord-290218-dvyeg5fk	57	23	RNA	rna	NN
cord-290218-dvyeg5fk	57	24	at	at	IN
cord-290218-dvyeg5fk	57	25	i+3	i+3	DT
cord-290218-dvyeg5fk	57	26	position	position	NN
cord-290218-dvyeg5fk	57	27	[	[	-LRB-
cord-290218-dvyeg5fk	57	28	42	42	CD
cord-290218-dvyeg5fk	57	29	]	]	-RRB-
cord-290218-dvyeg5fk	57	30	.	.	.
cord-290218-dvyeg5fk	58	1	When	when	WRB
cord-290218-dvyeg5fk	58	2	the	the	DT
cord-290218-dvyeg5fk	58	3	RNA	RNA	NNP
cord-290218-dvyeg5fk	58	4	synthesis	synthesis	NN
cord-290218-dvyeg5fk	58	5	process	process	NN
cord-290218-dvyeg5fk	58	6	to	to	IN
cord-290218-dvyeg5fk	58	7	the	the	DT
cord-290218-dvyeg5fk	58	8	i+3	i+3	NNP
cord-290218-dvyeg5fk	58	9	position	position	NN
cord-290218-dvyeg5fk	58	10	,	,	,
cord-290218-dvyeg5fk	58	11	the	the	DT
cord-290218-dvyeg5fk	58	12	incorporated	incorporate	VBN
cord-290218-dvyeg5fk	58	13	RTP	RTP	NNP
cord-290218-dvyeg5fk	58	14	will	will	MD
cord-290218-dvyeg5fk	58	15	be	be	VB
cord-290218-dvyeg5fk	58	16	at	at	IN
cord-290218-dvyeg5fk	58	17	-3	-3	NNP
cord-290218-dvyeg5fk	58	18	position	position	NN
cord-290218-dvyeg5fk	58	19	.	.	.
cord-290218-dvyeg5fk	59	1	The	the	DT
cord-290218-dvyeg5fk	59	2	molecular	molecular	JJ
cord-290218-dvyeg5fk	59	3	simulation	simulation	NN
cord-290218-dvyeg5fk	59	4	analysis	analysis	NN
cord-290218-dvyeg5fk	59	5	shows	show	VBZ
cord-290218-dvyeg5fk	59	6	that	that	IN
cord-290218-dvyeg5fk	59	7	the	the	DT
cord-290218-dvyeg5fk	59	8	1'-cyano	1'-cyano	CD
cord-290218-dvyeg5fk	59	9	substituent	substituent	NN
cord-290218-dvyeg5fk	59	10	of	of	IN
cord-290218-dvyeg5fk	59	11	incorporated	incorporate	VBN
cord-290218-dvyeg5fk	59	12	RDV	RDV	NNP
cord-290218-dvyeg5fk	59	13	sterically	sterically	RB
cord-290218-dvyeg5fk	59	14	clashed	clash	VBD
cord-290218-dvyeg5fk	59	15	with	with	IN
cord-290218-dvyeg5fk	59	16	the	the	DT
cord-290218-dvyeg5fk	59	17	side	side	NN
cord-290218-dvyeg5fk	59	18	chain	chain	NN
cord-290218-dvyeg5fk	59	19	of	of	IN
cord-290218-dvyeg5fk	59	20	S861	S861	NNP
cord-290218-dvyeg5fk	59	21	,	,	,
cord-290218-dvyeg5fk	59	22	a	a	DT
cord-290218-dvyeg5fk	59	23	residue	residue	NN
cord-290218-dvyeg5fk	59	24	faces	face	VBZ
cord-290218-dvyeg5fk	59	25	with	with	IN
cord-290218-dvyeg5fk	59	26	-3	-3	NNP
cord-290218-dvyeg5fk	59	27	position	position	NN
cord-290218-dvyeg5fk	59	28	,	,	,
cord-290218-dvyeg5fk	59	29	and	and	CC
cord-290218-dvyeg5fk	59	30	probably	probably	RB
cord-290218-dvyeg5fk	59	31	causes	cause	VBZ
cord-290218-dvyeg5fk	59	32	significant	significant	JJ
cord-290218-dvyeg5fk	59	33	distortion	distortion	NN
cord-290218-dvyeg5fk	59	34	of	of	IN
cord-290218-dvyeg5fk	59	35	the	the	DT
cord-290218-dvyeg5fk	59	36	position	position	NN
cord-290218-dvyeg5fk	59	37	of	of	IN
cord-290218-dvyeg5fk	59	38	RNA	RNA	NNP
cord-290218-dvyeg5fk	59	39	,	,	,
cord-290218-dvyeg5fk	59	40	hampering	hamper	VBG
cord-290218-dvyeg5fk	59	41	the	the	DT
cord-290218-dvyeg5fk	59	42	translocation	translocation	NN
cord-290218-dvyeg5fk	59	43	of	of	IN
cord-290218-dvyeg5fk	59	44	RNA	RNA	NNP
cord-290218-dvyeg5fk	59	45	to	to	IN
cord-290218-dvyeg5fk	59	46	the	the	DT
cord-290218-dvyeg5fk	59	47	-4	-4	CD
cord-290218-dvyeg5fk	59	48	position	position	NN
cord-290218-dvyeg5fk	59	49	[	[	-LRB-
cord-290218-dvyeg5fk	59	50	42	42	CD
cord-290218-dvyeg5fk	59	51	]	]	-RRB-
cord-290218-dvyeg5fk	59	52	.	.	.
cord-290218-dvyeg5fk	60	1	The	the	DT
cord-290218-dvyeg5fk	60	2	S861A	s861a	NN
cord-290218-dvyeg5fk	60	3	mutant	mutant	NN
cord-290218-dvyeg5fk	60	4	abates	abate	VBZ
cord-290218-dvyeg5fk	60	5	the	the	DT
cord-290218-dvyeg5fk	60	6	chain	chain	NN
cord-290218-dvyeg5fk	60	7	termination	termination	NN
cord-290218-dvyeg5fk	60	8	reaction	reaction	NN
cord-290218-dvyeg5fk	60	9	,	,	,
cord-290218-dvyeg5fk	60	10	supporting	support	VBG
cord-290218-dvyeg5fk	60	11	this	this	DT
cord-290218-dvyeg5fk	60	12	steric	steric	JJ
cord-290218-dvyeg5fk	60	13	clash	clash	NN
cord-290218-dvyeg5fk	60	14	hypothesis	hypothesis	NN
cord-290218-dvyeg5fk	60	15	for	for	IN
cord-290218-dvyeg5fk	60	16	the	the	DT
cord-290218-dvyeg5fk	60	17	delayed	delay	VBN
cord-290218-dvyeg5fk	60	18	chain	chain	NN
cord-290218-dvyeg5fk	60	19	termination	termination	NN
cord-290218-dvyeg5fk	60	20	[	[	-LRB-
cord-290218-dvyeg5fk	60	21	18	18	CD
cord-290218-dvyeg5fk	60	22	]	]	-RRB-
cord-290218-dvyeg5fk	60	23	.	.	.
cord-290218-dvyeg5fk	61	1	The	the	DT
cord-290218-dvyeg5fk	61	2	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	61	3	is	be	VBZ
cord-290218-dvyeg5fk	61	4	critical	critical	JJ
cord-290218-dvyeg5fk	61	5	for	for	IN
cord-290218-dvyeg5fk	61	6	the	the	DT
cord-290218-dvyeg5fk	61	7	replication	replication	NN
cord-290218-dvyeg5fk	61	8	of	of	IN
cord-290218-dvyeg5fk	61	9	viral	viral	JJ
cord-290218-dvyeg5fk	61	10	RNA	RNA	NNP
cord-290218-dvyeg5fk	61	11	,	,	,
cord-290218-dvyeg5fk	61	12	and	and	CC
cord-290218-dvyeg5fk	61	13	also	also	RB
cord-290218-dvyeg5fk	61	14	a	a	DT
cord-290218-dvyeg5fk	61	15	promising	promising	JJ
cord-290218-dvyeg5fk	61	16	drug	drug	NN
cord-290218-dvyeg5fk	61	17	target	target	NN
cord-290218-dvyeg5fk	61	18	for	for	IN
cord-290218-dvyeg5fk	61	19	COVID-19	covid-19	JJ
cord-290218-dvyeg5fk	61	20	treatment	treatment	NN
cord-290218-dvyeg5fk	61	21	.	.	.
cord-290218-dvyeg5fk	62	1	Firstly	firstly	RB
cord-290218-dvyeg5fk	62	2	,	,	,
cord-290218-dvyeg5fk	62	3	like	like	IN
cord-290218-dvyeg5fk	62	4	other	other	JJ
cord-290218-dvyeg5fk	62	5	proteins	protein	NNS
cord-290218-dvyeg5fk	62	6	of	of	IN
cord-290218-dvyeg5fk	62	7	SARS	SARS	NNP
cord-290218-dvyeg5fk	62	8	-	-	HYPH
cord-290218-dvyeg5fk	62	9	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	62	10	,	,	,
cord-290218-dvyeg5fk	62	11	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	62	12	lacks	lack	VBZ
cord-290218-dvyeg5fk	62	13	the	the	DT
cord-290218-dvyeg5fk	62	14	closed	close	VBN
cord-290218-dvyeg5fk	62	15	-	-	HYPH
cord-290218-dvyeg5fk	62	16	related	relate	VBN
cord-290218-dvyeg5fk	62	17	host	host	NN
cord-290218-dvyeg5fk	62	18	cell	cell	NN
cord-290218-dvyeg5fk	62	19	counterparts	counterpart	NNS
cord-290218-dvyeg5fk	62	20	.	.	.
cord-290218-dvyeg5fk	63	1	Thus	thus	RB
cord-290218-dvyeg5fk	63	2	,	,	,
cord-290218-dvyeg5fk	63	3	targeting	target	VBG
cord-290218-dvyeg5fk	63	4	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	63	5	may	may	MD
cord-290218-dvyeg5fk	63	6	circumvent	circumvent	VB
cord-290218-dvyeg5fk	63	7	the	the	DT
cord-290218-dvyeg5fk	63	8	off	off	JJ
cord-290218-dvyeg5fk	63	9	-	-	HYPH
cord-290218-dvyeg5fk	63	10	target	target	NN
cord-290218-dvyeg5fk	63	11	side	side	NN
cord-290218-dvyeg5fk	63	12	effects	effect	NNS
cord-290218-dvyeg5fk	63	13	.	.	.
cord-290218-dvyeg5fk	64	1	Secondly	secondly	RB
cord-290218-dvyeg5fk	64	2	,	,	,
cord-290218-dvyeg5fk	64	3	compared	compare	VBN
cord-290218-dvyeg5fk	64	4	to	to	IN
cord-290218-dvyeg5fk	64	5	the	the	DT
cord-290218-dvyeg5fk	64	6	spike	spike	NN
cord-290218-dvyeg5fk	64	7	protein	protein	NN
cord-290218-dvyeg5fk	64	8	and	and	CC
cord-290218-dvyeg5fk	64	9	other	other	JJ
cord-290218-dvyeg5fk	64	10	virus	virus	NN
cord-290218-dvyeg5fk	64	11	surface	surface	NN
cord-290218-dvyeg5fk	64	12	proteins	protein	NNS
cord-290218-dvyeg5fk	64	13	,	,	,
cord-290218-dvyeg5fk	64	14	the	the	DT
cord-290218-dvyeg5fk	64	15	active	active	JJ
cord-290218-dvyeg5fk	64	16	catalytic	catalytic	JJ
cord-290218-dvyeg5fk	64	17	motifs	motif	NNS
cord-290218-dvyeg5fk	64	18	of	of	IN
cord-290218-dvyeg5fk	64	19	the	the	DT
cord-290218-dvyeg5fk	64	20	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	64	21	are	be	VBP
cord-290218-dvyeg5fk	64	22	highly	highly	RB
cord-290218-dvyeg5fk	64	23	conserved	conserve	VBN
cord-290218-dvyeg5fk	64	24	among	among	IN
cord-290218-dvyeg5fk	64	25	RNA	RNA	NNP
cord-290218-dvyeg5fk	64	26	viruses	virus	NNS
cord-290218-dvyeg5fk	64	27	,	,	,
cord-290218-dvyeg5fk	64	28	making	make	VBG
cord-290218-dvyeg5fk	64	29	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	64	30	an	an	DT
cord-290218-dvyeg5fk	64	31	attractive	attractive	JJ
cord-290218-dvyeg5fk	64	32	antiviral	antiviral	JJ
cord-290218-dvyeg5fk	64	33	drug	drug	NN
cord-290218-dvyeg5fk	64	34	target	target	NN
cord-290218-dvyeg5fk	64	35	for	for	IN
cord-290218-dvyeg5fk	64	36	a	a	DT
cord-290218-dvyeg5fk	64	37	broad	broad	JJ
cord-290218-dvyeg5fk	64	38	-	-	HYPH
cord-290218-dvyeg5fk	64	39	spectrum	spectrum	NN
cord-290218-dvyeg5fk	64	40	of	of	IN
cord-290218-dvyeg5fk	64	41	viruses	virus	NNS
cord-290218-dvyeg5fk	64	42	.	.	.
cord-290218-dvyeg5fk	65	1	Several	several	JJ
cord-290218-dvyeg5fk	65	2	nucleoside	nucleoside	NN
cord-290218-dvyeg5fk	65	3	analog	analog	NN
cord-290218-dvyeg5fk	65	4	inhibitors	inhibitor	NNS
cord-290218-dvyeg5fk	65	5	have	have	VBP
cord-290218-dvyeg5fk	65	6	shown	show	VBN
cord-290218-dvyeg5fk	65	7	inhibitory	inhibitory	JJ
cord-290218-dvyeg5fk	65	8	activities	activity	NNS
cord-290218-dvyeg5fk	65	9	against	against	IN
cord-290218-dvyeg5fk	65	10	a	a	DT
cord-290218-dvyeg5fk	65	11	broad	broad	JJ
cord-290218-dvyeg5fk	65	12	spectrum	spectrum	NN
cord-290218-dvyeg5fk	65	13	of	of	IN
cord-290218-dvyeg5fk	65	14	RNA	RNA	NNP
cord-290218-dvyeg5fk	65	15	viruses	virus	NNS
cord-290218-dvyeg5fk	65	16	[	[	-LRB-
cord-290218-dvyeg5fk	65	17	43	43	CD
cord-290218-dvyeg5fk	65	18	]	]	-RRB-
cord-290218-dvyeg5fk	65	19	.	.	.
cord-290218-dvyeg5fk	66	1	therapeutics	therapeutic	NNS
cord-290218-dvyeg5fk	66	2	.	.	.
cord-290218-dvyeg5fk	67	1	The	the	DT
cord-290218-dvyeg5fk	67	2	replication	replication	NN
cord-290218-dvyeg5fk	67	3	and	and	CC
cord-290218-dvyeg5fk	67	4	transcription	transcription	NN
cord-290218-dvyeg5fk	67	5	of	of	IN
cord-290218-dvyeg5fk	67	6	SARS	SARS	NNP
cord-290218-dvyeg5fk	67	7	-	-	HYPH
cord-290218-dvyeg5fk	67	8	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	67	9	is	be	VBZ
cord-290218-dvyeg5fk	67	10	a	a	DT
cord-290218-dvyeg5fk	67	11	spatiotemporally	spatiotemporally	RB
cord-290218-dvyeg5fk	67	12	regulated	regulate	VBN
cord-290218-dvyeg5fk	67	13	multi	multi	JJ
cord-290218-dvyeg5fk	67	14	-	-	JJ
cord-290218-dvyeg5fk	67	15	step	step	JJ
cord-290218-dvyeg5fk	67	16	process	process	NN
cord-290218-dvyeg5fk	67	17	,	,	,
cord-290218-dvyeg5fk	67	18	which	which	WDT
cord-290218-dvyeg5fk	67	19	is	be	VBZ
cord-290218-dvyeg5fk	67	20	mediated	mediate	VBN
cord-290218-dvyeg5fk	67	21	by	by	IN
cord-290218-dvyeg5fk	67	22	the	the	DT
cord-290218-dvyeg5fk	67	23	replication	replication	NN
cord-290218-dvyeg5fk	67	24	-	-	HYPH
cord-290218-dvyeg5fk	67	25	transcription	transcription	NN
cord-290218-dvyeg5fk	67	26	complex	complex	NN
cord-290218-dvyeg5fk	67	27	composed	compose	VBN
cord-290218-dvyeg5fk	67	28	by	by	IN
cord-290218-dvyeg5fk	67	29	primarily	primarily	RB
cord-290218-dvyeg5fk	67	30	the	the	DT
cord-290218-dvyeg5fk	67	31	virus	virus	NN
cord-290218-dvyeg5fk	67	32	-	-	HYPH
cord-290218-dvyeg5fk	67	33	encoded	encode	VBN
cord-290218-dvyeg5fk	67	34	non	non	JJ
cord-290218-dvyeg5fk	67	35	-	-	JJ
cord-290218-dvyeg5fk	67	36	structural	structural	JJ
cord-290218-dvyeg5fk	67	37	proteins	protein	NNS
cord-290218-dvyeg5fk	67	38	.	.	.
cord-290218-dvyeg5fk	68	1	The	the	DT
cord-290218-dvyeg5fk	68	2	field	field	NN
cord-290218-dvyeg5fk	68	3	of	of	IN
cord-290218-dvyeg5fk	68	4	structural	structural	JJ
cord-290218-dvyeg5fk	68	5	studies	study	NNS
cord-290218-dvyeg5fk	68	6	on	on	IN
cord-290218-dvyeg5fk	68	7	the	the	DT
cord-290218-dvyeg5fk	68	8	RTC	RTC	NNP
cord-290218-dvyeg5fk	68	9	is	be	VBZ
cord-290218-dvyeg5fk	68	10	rapidly	rapidly	RB
cord-290218-dvyeg5fk	68	11	developed	develop	VBN
cord-290218-dvyeg5fk	68	12	,	,	,
cord-290218-dvyeg5fk	68	13	as	as	IN
cord-290218-dvyeg5fk	68	14	witnessed	witness	VBN
cord-290218-dvyeg5fk	68	15	by	by	IN
cord-290218-dvyeg5fk	68	16	the	the	DT
cord-290218-dvyeg5fk	68	17	copious	copious	JJ
cord-290218-dvyeg5fk	68	18	amount	amount	NN
cord-290218-dvyeg5fk	68	19	of	of	IN
cord-290218-dvyeg5fk	68	20	the	the	DT
cord-290218-dvyeg5fk	68	21	recent	recent	JJ
cord-290218-dvyeg5fk	68	22	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	68	23	complex	complex	JJ
cord-290218-dvyeg5fk	68	24	structures	structure	NNS
cord-290218-dvyeg5fk	68	25	J	J	NNP
cord-290218-dvyeg5fk	68	26	o	o	NN
cord-290218-dvyeg5fk	68	27	u	u	NN
cord-290218-dvyeg5fk	68	28	r	r	NN
cord-290218-dvyeg5fk	68	29	n	n	NN
cord-290218-dvyeg5fk	68	30	a	a	DT
cord-290218-dvyeg5fk	68	31	l	l	NN
cord-290218-dvyeg5fk	68	32	P	p	NN
cord-290218-dvyeg5fk	68	33	r	r	NN
cord-290218-dvyeg5fk	68	34	e	e	NN
cord-290218-dvyeg5fk	68	35	-p	-p	NN
cord-290218-dvyeg5fk	69	1	r	r	LS
cord-290218-dvyeg5fk	69	2	o	o	NN
cord-290218-dvyeg5fk	70	1	o	o	UH
cord-290218-dvyeg5fk	70	2	f	f	NNP
cord-290218-dvyeg5fk	70	3	[	[	-LRB-
cord-290218-dvyeg5fk	70	4	16	16	CD
cord-290218-dvyeg5fk	70	5	]	]	-RRB-
cord-290218-dvyeg5fk	71	1	[	[	-LRB-
cord-290218-dvyeg5fk	71	2	17	17	CD
cord-290218-dvyeg5fk	71	3	]	]	-RRB-
cord-290218-dvyeg5fk	71	4	[	[	-LRB-
cord-290218-dvyeg5fk	71	5	18	18	CD
cord-290218-dvyeg5fk	71	6	]	]	-RRB-
cord-290218-dvyeg5fk	71	7	[	[	-LRB-
cord-290218-dvyeg5fk	71	8	19	19	CD
cord-290218-dvyeg5fk	71	9	]	]	-RRB-
cord-290218-dvyeg5fk	71	10	38	38	CD
cord-290218-dvyeg5fk	71	11	]	]	-RRB-
cord-290218-dvyeg5fk	71	12	.	.	.
cord-290218-dvyeg5fk	72	1	Recently	recently	RB
cord-290218-dvyeg5fk	72	2	,	,	,
cord-290218-dvyeg5fk	72	3	a	a	DT
cord-290218-dvyeg5fk	72	4	structure	structure	NN
cord-290218-dvyeg5fk	72	5	of	of	IN
cord-290218-dvyeg5fk	72	6	SARS	SARS	NNP
cord-290218-dvyeg5fk	72	7	-	-	HYPH
cord-290218-dvyeg5fk	72	8	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	72	9	holo	holo	JJ
cord-290218-dvyeg5fk	72	10	-	-	HYPH
cord-290218-dvyeg5fk	72	11	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	72	12	-	-	HYPH
cord-290218-dvyeg5fk	72	13	RNA	RNA	NNP
cord-290218-dvyeg5fk	72	14	in	in	IN
cord-290218-dvyeg5fk	72	15	complex	complex	NN
cord-290218-dvyeg5fk	72	16	with	with	IN
cord-290218-dvyeg5fk	72	17	two	two	CD
cord-290218-dvyeg5fk	72	18	molecules	molecule	NNS
cord-290218-dvyeg5fk	72	19	of	of	IN
cord-290218-dvyeg5fk	72	20	the	the	DT
cord-290218-dvyeg5fk	72	21	nsp13	nsp13	CD
cord-290218-dvyeg5fk	72	22	helicase	helicase	NN
cord-290218-dvyeg5fk	72	23	was	be	VBD
cord-290218-dvyeg5fk	72	24	pre	pre	VBN
cord-290218-dvyeg5fk	72	25	-	-	VBN
cord-290218-dvyeg5fk	72	26	released	release	VBN
cord-290218-dvyeg5fk	72	27	,	,	,
cord-290218-dvyeg5fk	72	28	providing	provide	VBG
cord-290218-dvyeg5fk	72	29	a	a	DT
cord-290218-dvyeg5fk	72	30	structural	structural	JJ
cord-290218-dvyeg5fk	72	31	basis	basis	NN
cord-290218-dvyeg5fk	72	32	for	for	IN
cord-290218-dvyeg5fk	72	33	putative	putative	JJ
cord-290218-dvyeg5fk	72	34	nsp13	nsp13	NNP
cord-290218-dvyeg5fk	72	35	helicase	helicase	NN
cord-290218-dvyeg5fk	72	36	functions	function	NNS
cord-290218-dvyeg5fk	72	37	during	during	IN
cord-290218-dvyeg5fk	72	38	viral	viral	JJ
cord-290218-dvyeg5fk	72	39	genome	genome	NN
cord-290218-dvyeg5fk	72	40	replication	replication	NN
cord-290218-dvyeg5fk	72	41	and	and	CC
cord-290218-dvyeg5fk	72	42	transcription	transcription	NN
cord-290218-dvyeg5fk	72	43	[	[	-LRB-
cord-290218-dvyeg5fk	72	44	40	40	CD
cord-290218-dvyeg5fk	72	45	]	]	-RRB-
cord-290218-dvyeg5fk	72	46	.	.	.
cord-290218-dvyeg5fk	73	1	The	the	DT
cord-290218-dvyeg5fk	73	2	structures	structure	NNS
cord-290218-dvyeg5fk	73	3	of	of	IN
cord-290218-dvyeg5fk	73	4	SARS	SARS	NNP
cord-290218-dvyeg5fk	73	5	-	-	HYPH
cord-290218-dvyeg5fk	73	6	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	73	7	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	73	8	and	and	CC
cord-290218-dvyeg5fk	73	9	lessons	lesson	NNS
cord-290218-dvyeg5fk	73	10	learned	learn	VBN
cord-290218-dvyeg5fk	73	11	from	from	IN
cord-290218-dvyeg5fk	73	12	other	other	JJ
cord-290218-dvyeg5fk	73	13	coronaviruses	coronaviruse	NNS
cord-290218-dvyeg5fk	73	14	have	have	VBP
cord-290218-dvyeg5fk	73	15	shed	shed	VBN
cord-290218-dvyeg5fk	73	16	light	light	NN
cord-290218-dvyeg5fk	73	17	on	on	IN
cord-290218-dvyeg5fk	73	18	the	the	DT
cord-290218-dvyeg5fk	73	19	mechanisms	mechanism	NNS
cord-290218-dvyeg5fk	73	20	of	of	IN
cord-290218-dvyeg5fk	73	21	RNA	RNA	NNP
cord-290218-dvyeg5fk	73	22	binding	binding	NN
cord-290218-dvyeg5fk	73	23	and	and	CC
cord-290218-dvyeg5fk	73	24	inhibitor	inhibitor	NN
cord-290218-dvyeg5fk	73	25	recognition	recognition	NN
cord-290218-dvyeg5fk	73	26	of	of	IN
cord-290218-dvyeg5fk	73	27	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	73	28	.	.	.
cord-290218-dvyeg5fk	74	1	However	however	RB
cord-290218-dvyeg5fk	74	2	,	,	,
cord-290218-dvyeg5fk	74	3	the	the	DT
cord-290218-dvyeg5fk	74	4	structural	structural	JJ
cord-290218-dvyeg5fk	74	5	organization	organization	NN
cord-290218-dvyeg5fk	74	6	and	and	CC
cord-290218-dvyeg5fk	74	7	the	the	DT
cord-290218-dvyeg5fk	74	8	regulation	regulation	NN
cord-290218-dvyeg5fk	74	9	mechanism	mechanism	NN
cord-290218-dvyeg5fk	74	10	of	of	IN
cord-290218-dvyeg5fk	74	11	the	the	DT
cord-290218-dvyeg5fk	74	12	replication	replication	NN
cord-290218-dvyeg5fk	74	13	-	-	HYPH
cord-290218-dvyeg5fk	74	14	transcription	transcription	NN
cord-290218-dvyeg5fk	74	15	complex	complex	NN
cord-290218-dvyeg5fk	74	16	have	have	VBP
cord-290218-dvyeg5fk	74	17	not	not	RB
cord-290218-dvyeg5fk	74	18	been	be	VBN
cord-290218-dvyeg5fk	74	19	thoroughly	thoroughly	RB
cord-290218-dvyeg5fk	74	20	studied	study	VBN
cord-290218-dvyeg5fk	74	21	.	.	.
cord-290218-dvyeg5fk	75	1	More	More	JJR
cord-290218-dvyeg5fk	75	2	high	high	JJ
cord-290218-dvyeg5fk	75	3	-	-	HYPH
cord-290218-dvyeg5fk	75	4	resolution	resolution	NN
cord-290218-dvyeg5fk	75	5	structures	structure	NNS
cord-290218-dvyeg5fk	75	6	with	with	IN
cord-290218-dvyeg5fk	75	7	diverse	diverse	JJ
cord-290218-dvyeg5fk	75	8	nsps	nsp	NNS
cord-290218-dvyeg5fk	75	9	organizations	organization	NNS
cord-290218-dvyeg5fk	75	10	are	be	VBP
cord-290218-dvyeg5fk	75	11	essential	essential	JJ
cord-290218-dvyeg5fk	75	12	to	to	TO
cord-290218-dvyeg5fk	75	13	understand	understand	VB
cord-290218-dvyeg5fk	75	14	how	how	WRB
cord-290218-dvyeg5fk	75	15	these	these	DT
cord-290218-dvyeg5fk	75	16	cofactors	cofactor	NNS
cord-290218-dvyeg5fk	75	17	conduct	conduct	VBP
cord-290218-dvyeg5fk	75	18	the	the	DT
cord-290218-dvyeg5fk	75	19	orchestra	orchestra	NN
cord-290218-dvyeg5fk	75	20	of	of	IN
cord-290218-dvyeg5fk	75	21	RNA	RNA	NNP
cord-290218-dvyeg5fk	75	22	processing	processing	NN
cord-290218-dvyeg5fk	75	23	enzyme	enzyme	NN
cord-290218-dvyeg5fk	75	24	to	to	TO
cord-290218-dvyeg5fk	75	25	achieve	achieve	VB
cord-290218-dvyeg5fk	75	26	the	the	DT
cord-290218-dvyeg5fk	75	27	replication	replication	NN
cord-290218-dvyeg5fk	75	28	and	and	CC
cord-290218-dvyeg5fk	75	29	transcription	transcription	NN
cord-290218-dvyeg5fk	75	30	of	of	IN
cord-290218-dvyeg5fk	75	31	virus	virus	NN
cord-290218-dvyeg5fk	75	32	RNA	RNA	NNP
cord-290218-dvyeg5fk	75	33	.	.	.
cord-290218-dvyeg5fk	76	1	Moreover	moreover	RB
cord-290218-dvyeg5fk	76	2	,	,	,
cord-290218-dvyeg5fk	76	3	the	the	DT
cord-290218-dvyeg5fk	76	4	complete	complete	JJ
cord-290218-dvyeg5fk	76	5	picture	picture	NN
cord-290218-dvyeg5fk	76	6	of	of	IN
cord-290218-dvyeg5fk	76	7	intricate	intricate	JJ
cord-290218-dvyeg5fk	76	8	RNA	RNA	NNP
cord-290218-dvyeg5fk	76	9	processing	processing	NN
cord-290218-dvyeg5fk	76	10	will	will	MD
cord-290218-dvyeg5fk	76	11	also	also	RB
cord-290218-dvyeg5fk	76	12	provide	provide	VB
cord-290218-dvyeg5fk	76	13	new	new	JJ
cord-290218-dvyeg5fk	76	14	candidate	candidate	NN
cord-290218-dvyeg5fk	76	15	targets	target	NNS
cord-290218-dvyeg5fk	76	16	for	for	IN
cord-290218-dvyeg5fk	76	17	designing	design	VBG
cord-290218-dvyeg5fk	76	18	drugs	drug	NNS
cord-290218-dvyeg5fk	76	19	against	against	IN
cord-290218-dvyeg5fk	76	20	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	76	21	.	.	.
cord-290218-dvyeg5fk	76	22	 	 	_SP
cord-290218-dvyeg5fk	77	1	China	China	NNP
cord-290218-dvyeg5fk	77	2	Novel	Novel	NNP
cord-290218-dvyeg5fk	77	3	Coronavirus	Coronavirus	NNP
cord-290218-dvyeg5fk	77	4	,	,	,
cord-290218-dvyeg5fk	77	5	T.	T.	NNP
cord-290218-dvyeg5fk	77	6	Research	Research	NNP
cord-290218-dvyeg5fk	77	7	,	,	,
cord-290218-dvyeg5fk	77	8	A	a	DT
cord-290218-dvyeg5fk	77	9	Novel	Novel	NNP
cord-290218-dvyeg5fk	77	10	Coronavirus	Coronavirus	NNP
cord-290218-dvyeg5fk	77	11	from	from	IN
cord-290218-dvyeg5fk	77	12	Patients	patient	NNS
cord-290218-dvyeg5fk	77	13	with	with	IN
cord-290218-dvyeg5fk	77	14	Pneumonia	Pneumonia	NNP
cord-290218-dvyeg5fk	77	15	in	in	IN
cord-290218-dvyeg5fk	77	16	China	China	NNP
cord-290218-dvyeg5fk	78	1	A	a	DT
cord-290218-dvyeg5fk	78	2	new	new	JJ
cord-290218-dvyeg5fk	78	3	coronavirus	coronavirus	NN
cord-290218-dvyeg5fk	78	4	associated	associate	VBN
cord-290218-dvyeg5fk	78	5	with	with	IN
cord-290218-dvyeg5fk	78	6	human	human	JJ
cord-290218-dvyeg5fk	78	7	respiratory	respiratory	JJ
cord-290218-dvyeg5fk	78	8	disease	disease	NN
cord-290218-dvyeg5fk	78	9	in	in	IN
cord-290218-dvyeg5fk	78	10	China	China	NNP
cord-290218-dvyeg5fk	79	1	A	a	DT
cord-290218-dvyeg5fk	79	2	pneumonia	pneumonia	NN
cord-290218-dvyeg5fk	79	3	outbreak	outbreak	NN
cord-290218-dvyeg5fk	79	4	associated	associate	VBN
cord-290218-dvyeg5fk	79	5	with	with	IN
cord-290218-dvyeg5fk	79	6	a	a	DT
cord-290218-dvyeg5fk	79	7	new	new	JJ
cord-290218-dvyeg5fk	79	8	coronavirus	coronavirus	NN
cord-290218-dvyeg5fk	79	9	of	of	IN
cord-290218-dvyeg5fk	79	10	probable	probable	JJ
cord-290218-dvyeg5fk	79	11	bat	bat	NN
cord-290218-dvyeg5fk	79	12	origin	origin	NN
cord-290218-dvyeg5fk	80	1	Identifying	identify	VBG
cord-290218-dvyeg5fk	80	2	SARS	SARS	NNP
cord-290218-dvyeg5fk	80	3	-	-	HYPH
cord-290218-dvyeg5fk	80	4	CoV-2-related	cov-2-relate	VBN
cord-290218-dvyeg5fk	80	5	coronaviruses	coronaviruse	NNS
cord-290218-dvyeg5fk	80	6	in	in	IN
cord-290218-dvyeg5fk	80	7	Malayan	malayan	JJ
cord-290218-dvyeg5fk	80	8	pangolins	pangolin	NNS
cord-290218-dvyeg5fk	81	1	Probable	probable	JJ
cord-290218-dvyeg5fk	81	2	Pangolin	Pangolin	NNP
cord-290218-dvyeg5fk	81	3	Origin	Origin	NNP
cord-290218-dvyeg5fk	81	4	of	of	IN
cord-290218-dvyeg5fk	81	5	SARS	SARS	NNP
cord-290218-dvyeg5fk	81	6	-	-	HYPH
cord-290218-dvyeg5fk	81	7	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	82	1	Associated	associate	VBN
cord-290218-dvyeg5fk	82	2	with	with	IN
cord-290218-dvyeg5fk	82	3	the	the	DT
cord-290218-dvyeg5fk	82	4	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	82	5	Outbreak	Outbreak	NNP
cord-290218-dvyeg5fk	82	6	Polymerase	Polymerase	NNP
cord-290218-dvyeg5fk	82	7	as	as	IN
cord-290218-dvyeg5fk	82	8	a	a	DT
cord-290218-dvyeg5fk	82	9	Target	Target	NNP
cord-290218-dvyeg5fk	82	10	for	for	IN
cord-290218-dvyeg5fk	82	11	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	82	12	Drug	Drug	NNP
cord-290218-dvyeg5fk	82	13	Discovery	Discovery	NNP
cord-290218-dvyeg5fk	82	14	Structural	Structural	NNP
cord-290218-dvyeg5fk	82	15	basis	basis	NN
cord-290218-dvyeg5fk	82	16	for	for	IN
cord-290218-dvyeg5fk	82	17	the	the	DT
cord-290218-dvyeg5fk	82	18	recognition	recognition	NN
cord-290218-dvyeg5fk	82	19	of	of	IN
cord-290218-dvyeg5fk	82	20	SARS	SARS	NNP
cord-290218-dvyeg5fk	82	21	-	-	HYPH
cord-290218-dvyeg5fk	82	22	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	82	23	by	by	IN
cord-290218-dvyeg5fk	82	24	full	full	JJ
cord-290218-dvyeg5fk	82	25	-	-	HYPH
cord-290218-dvyeg5fk	82	26	length	length	NN
cord-290218-dvyeg5fk	82	27	human	human	JJ
cord-290218-dvyeg5fk	82	28	ACE2	ACE2	NNP
cord-290218-dvyeg5fk	82	29	Cryo	Cryo	NNP
cord-290218-dvyeg5fk	82	30	-	-	HYPH
cord-290218-dvyeg5fk	82	31	EM	EM	NNP
cord-290218-dvyeg5fk	82	32	structure	structure	NN
cord-290218-dvyeg5fk	82	33	of	of	IN
cord-290218-dvyeg5fk	82	34	the	the	DT
cord-290218-dvyeg5fk	82	35	2019-nCoV	2019-ncov	CD
cord-290218-dvyeg5fk	82	36	spike	spike	NN
cord-290218-dvyeg5fk	82	37	in	in	IN
cord-290218-dvyeg5fk	82	38	the	the	DT
cord-290218-dvyeg5fk	82	39	prefusion	prefusion	NN
cord-290218-dvyeg5fk	82	40	conformation	conformation	NNP
cord-290218-dvyeg5fk	82	41	Structure	Structure	NNP
cord-290218-dvyeg5fk	82	42	of	of	IN
cord-290218-dvyeg5fk	82	43	the	the	DT
cord-290218-dvyeg5fk	82	44	SARS	SARS	NNP
cord-290218-dvyeg5fk	82	45	-	-	HYPH
cord-290218-dvyeg5fk	82	46	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	82	47	spike	spike	NN
cord-290218-dvyeg5fk	82	48	receptor	receptor	NN
cord-290218-dvyeg5fk	82	49	-	-	HYPH
cord-290218-dvyeg5fk	82	50	binding	bind	VBG
cord-290218-dvyeg5fk	82	51	domain	domain	NN
cord-290218-dvyeg5fk	82	52	bound	bind	VBN
cord-290218-dvyeg5fk	82	53	to	to	IN
cord-290218-dvyeg5fk	82	54	the	the	DT
cord-290218-dvyeg5fk	82	55	ACE2	ACE2	NNP
cord-290218-dvyeg5fk	82	56	receptor	receptor	NN
cord-290218-dvyeg5fk	82	57	Structural	structural	JJ
cord-290218-dvyeg5fk	82	58	basis	basis	NN
cord-290218-dvyeg5fk	82	59	of	of	IN
cord-290218-dvyeg5fk	82	60	receptor	receptor	NN
cord-290218-dvyeg5fk	82	61	recognition	recognition	NN
cord-290218-dvyeg5fk	82	62	by	by	IN
cord-290218-dvyeg5fk	82	63	SARS	SARS	NNP
cord-290218-dvyeg5fk	82	64	-	-	HYPH
cord-290218-dvyeg5fk	82	65	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	82	66	Structure	Structure	NNP
cord-290218-dvyeg5fk	82	67	,	,	,
cord-290218-dvyeg5fk	82	68	Function	Function	NNP
cord-290218-dvyeg5fk	82	69	,	,	,
cord-290218-dvyeg5fk	82	70	and	and	CC
cord-290218-dvyeg5fk	82	71	Antigenicity	Antigenicity	NNP
cord-290218-dvyeg5fk	82	72	of	of	IN
cord-290218-dvyeg5fk	82	73	the	the	DT
cord-290218-dvyeg5fk	82	74	SARS	SARS	NNP
cord-290218-dvyeg5fk	82	75	-	-	HYPH
cord-290218-dvyeg5fk	82	76	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	82	77	Spike	Spike	NNP
cord-290218-dvyeg5fk	82	78	Glycoprotein	glycoprotein	NN
cord-290218-dvyeg5fk	82	79	Tracking	tracking	NN
cord-290218-dvyeg5fk	82	80	Changes	change	NNS
cord-290218-dvyeg5fk	82	81	in	in	IN
cord-290218-dvyeg5fk	82	82	SARS	SARS	NNP
cord-290218-dvyeg5fk	82	83	-	-	HYPH
cord-290218-dvyeg5fk	82	84	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	82	85	Spike	spike	NN
cord-290218-dvyeg5fk	82	86	:	:	:
cord-290218-dvyeg5fk	82	87	Evidence	evidence	NN
cord-290218-dvyeg5fk	82	88	that	that	IN
cord-290218-dvyeg5fk	82	89	D614	d614	NN
cord-290218-dvyeg5fk	82	90	G	g	NN
cord-290218-dvyeg5fk	82	91	Increases	Increases	NNPS
cord-290218-dvyeg5fk	82	92	Infectivity	infectivity	NN
cord-290218-dvyeg5fk	82	93	of	of	IN
cord-290218-dvyeg5fk	82	94	the	the	DT
cord-290218-dvyeg5fk	82	95	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	82	96	Virus	Virus	NNP
cord-290218-dvyeg5fk	82	97	Remdesivir	Remdesivir	NNP
cord-290218-dvyeg5fk	82	98	and	and	CC
cord-290218-dvyeg5fk	82	99	chloroquine	chloroquine	NN
cord-290218-dvyeg5fk	82	100	effectively	effectively	RB
cord-290218-dvyeg5fk	82	101	inhibit	inhibit	VBP
cord-290218-dvyeg5fk	82	102	the	the	DT
cord-290218-dvyeg5fk	82	103	recently	recently	RB
cord-290218-dvyeg5fk	82	104	emerged	emerge	VBN
cord-290218-dvyeg5fk	82	105	novel	novel	JJ
cord-290218-dvyeg5fk	82	106	coronavirus	coronavirus	NN
cord-290218-dvyeg5fk	82	107	(	(	-LRB-
cord-290218-dvyeg5fk	82	108	2019-nCoV	2019-ncov	CD
cord-290218-dvyeg5fk	82	109	)	)	-RRB-
cord-290218-dvyeg5fk	82	110	in	in	IN
cord-290218-dvyeg5fk	82	111	vitro	vitro	FW
cord-290218-dvyeg5fk	82	112	Washington	Washington	NNP
cord-290218-dvyeg5fk	82	113	State	State	NNP
cord-290218-dvyeg5fk	82	114	-nCo	-nCo	NNP
cord-290218-dvyeg5fk	82	115	,	,	,
cord-290218-dvyeg5fk	82	116	First	First	NNP
cord-290218-dvyeg5fk	82	117	Case	Case	NNP
cord-290218-dvyeg5fk	82	118	of	of	IN
cord-290218-dvyeg5fk	82	119	2019	2019	CD
cord-290218-dvyeg5fk	82	120	Novel	Novel	NNP
cord-290218-dvyeg5fk	82	121	Coronavirus	Coronavirus	NNP
cord-290218-dvyeg5fk	82	122	in	in	IN
cord-290218-dvyeg5fk	82	123	the	the	DT
cord-290218-dvyeg5fk	82	124	United	United	NNP
cord-290218-dvyeg5fk	82	125	States	States	NNP
cord-290218-dvyeg5fk	82	126	Broad	Broad	NNP
cord-290218-dvyeg5fk	82	127	-	-	HYPH
cord-290218-dvyeg5fk	82	128	spectrum	spectrum	NN
cord-290218-dvyeg5fk	82	129	antiviral	antiviral	JJ
cord-290218-dvyeg5fk	82	130	GS-5734	GS-5734	NNS
cord-290218-dvyeg5fk	83	1	inhibits	inhibit	NNS
cord-290218-dvyeg5fk	83	2	both	both	DT
cord-290218-dvyeg5fk	83	3	epidemic	epidemic	NN
cord-290218-dvyeg5fk	83	4	and	and	CC
cord-290218-dvyeg5fk	83	5	zoonotic	zoonotic	JJ
cord-290218-dvyeg5fk	83	6	coronaviruses	coronaviruses	NNPS
cord-290218-dvyeg5fk	83	7	Structure	Structure	NNP
cord-290218-dvyeg5fk	83	8	of	of	IN
cord-290218-dvyeg5fk	83	9	the	the	DT
cord-290218-dvyeg5fk	83	10	RNA	RNA	NNP
cord-290218-dvyeg5fk	83	11	-	-	HYPH
cord-290218-dvyeg5fk	83	12	dependent	dependent	JJ
cord-290218-dvyeg5fk	83	13	RNA	RNA	NNP
cord-290218-dvyeg5fk	83	14	polymerase	polymerase	NN
cord-290218-dvyeg5fk	83	15	from	from	IN
cord-290218-dvyeg5fk	83	16	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	83	17	virus	virus	NN
cord-290218-dvyeg5fk	83	18	Structural	structural	JJ
cord-290218-dvyeg5fk	83	19	basis	basis	NN
cord-290218-dvyeg5fk	83	20	for	for	IN
cord-290218-dvyeg5fk	83	21	inhibition	inhibition	NN
cord-290218-dvyeg5fk	83	22	of	of	IN
cord-290218-dvyeg5fk	83	23	the	the	DT
cord-290218-dvyeg5fk	83	24	RNA	RNA	NNP
cord-290218-dvyeg5fk	83	25	-	-	HYPH
cord-290218-dvyeg5fk	83	26	dependent	dependent	JJ
cord-290218-dvyeg5fk	83	27	RNA	RNA	NNP
cord-290218-dvyeg5fk	83	28	polymerase	polymerase	NN
cord-290218-dvyeg5fk	83	29	from	from	IN
cord-290218-dvyeg5fk	83	30	SARS	SARS	NNP
cord-290218-dvyeg5fk	83	31	-	-	HYPH
cord-290218-dvyeg5fk	83	32	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	83	33	by	by	IN
cord-290218-dvyeg5fk	83	34	remdesivir	remdesivir	NNP
cord-290218-dvyeg5fk	83	35	Structural	Structural	NNP
cord-290218-dvyeg5fk	83	36	Basis	Basis	NNP
cord-290218-dvyeg5fk	83	37	for	for	IN
cord-290218-dvyeg5fk	83	38	RNA	RNA	NNP
cord-290218-dvyeg5fk	83	39	Replication	Replication	NNP
cord-290218-dvyeg5fk	83	40	by	by	IN
cord-290218-dvyeg5fk	83	41	the	the	DT
cord-290218-dvyeg5fk	83	42	SARS	SARS	NNP
cord-290218-dvyeg5fk	83	43	-	-	HYPH
cord-290218-dvyeg5fk	83	44	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	83	45	Polymerase	Polymerase	NNP
cord-290218-dvyeg5fk	83	46	Structural	Structural	NNP
cord-290218-dvyeg5fk	83	47	and	and	CC
cord-290218-dvyeg5fk	83	48	Biochemical	biochemical	JJ
cord-290218-dvyeg5fk	83	49	Characterization	characterization	NN
cord-290218-dvyeg5fk	83	50	of	of	IN
cord-290218-dvyeg5fk	83	51	the	the	DT
cord-290218-dvyeg5fk	83	52	nsp12-nsp7-nsp8	nsp12-nsp7-nsp8	NNP
cord-290218-dvyeg5fk	83	53	Core	Core	NNP
cord-290218-dvyeg5fk	83	54	Polymerase	Polymerase	NNP
cord-290218-dvyeg5fk	83	55	Complex	Complex	NNP
cord-290218-dvyeg5fk	83	56	from	from	IN
cord-290218-dvyeg5fk	83	57	SARS	SARS	NNP
cord-290218-dvyeg5fk	83	58	-	-	HYPH
cord-290218-dvyeg5fk	83	59	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	83	60	Structural	structural	JJ
cord-290218-dvyeg5fk	83	61	basis	basis	NN
cord-290218-dvyeg5fk	83	62	for	for	IN
cord-290218-dvyeg5fk	83	63	translational	translational	JJ
cord-290218-dvyeg5fk	83	64	shutdown	shutdown	NN
cord-290218-dvyeg5fk	83	65	and	and	CC
cord-290218-dvyeg5fk	83	66	immune	immune	JJ
cord-290218-dvyeg5fk	83	67	evasion	evasion	NN
cord-290218-dvyeg5fk	83	68	by	by	IN
cord-290218-dvyeg5fk	83	69	the	the	DT
cord-290218-dvyeg5fk	83	70	Nsp1	Nsp1	NNP
cord-290218-dvyeg5fk	83	71	protein	protein	NN
cord-290218-dvyeg5fk	83	72	of	of	IN
cord-290218-dvyeg5fk	83	73	SARS	SARS	NNP
cord-290218-dvyeg5fk	83	74	-	-	HYPH
cord-290218-dvyeg5fk	83	75	CoV	CoV	NNP
cord-290218-dvyeg5fk	83	76	Nonstructural	Nonstructural	NNP
cord-290218-dvyeg5fk	83	77	protein	protein	NN
cord-290218-dvyeg5fk	83	78	1	1	CD
cord-290218-dvyeg5fk	83	79	of	of	IN
cord-290218-dvyeg5fk	83	80	SARS	SARS	NNP
cord-290218-dvyeg5fk	83	81	-	-	HYPH
cord-290218-dvyeg5fk	83	82	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	84	1	is	be	VBZ
cord-290218-dvyeg5fk	84	2	a	a	DT
cord-290218-dvyeg5fk	84	3	potent	potent	JJ
cord-290218-dvyeg5fk	84	4	pathogenicity	pathogenicity	NN
cord-290218-dvyeg5fk	84	5	factor	factor	NN
cord-290218-dvyeg5fk	84	6	redirecting	redirect	VBG
cord-290218-dvyeg5fk	84	7	host	host	NN
cord-290218-dvyeg5fk	84	8	protein	protein	NN
cord-290218-dvyeg5fk	84	9	synthesis	synthesis	NN
cord-290218-dvyeg5fk	84	10	machinery	machinery	NN
cord-290218-dvyeg5fk	84	11	toward	toward	IN
cord-290218-dvyeg5fk	84	12	viral	viral	JJ
cord-290218-dvyeg5fk	84	13	RNA	RNA	NNP
cord-290218-dvyeg5fk	84	14	Crystal	Crystal	NNP
cord-290218-dvyeg5fk	84	15	structure	structure	NN
cord-290218-dvyeg5fk	84	16	of	of	IN
cord-290218-dvyeg5fk	84	17	the	the	DT
cord-290218-dvyeg5fk	84	18	SARS	SARS	NNP
cord-290218-dvyeg5fk	84	19	-	-	HYPH
cord-290218-dvyeg5fk	84	20	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	84	21	non	non	JJ
cord-290218-dvyeg5fk	84	22	-	-	JJ
cord-290218-dvyeg5fk	84	23	structural	structural	JJ
cord-290218-dvyeg5fk	84	24	protein	protein	NN
cord-290218-dvyeg5fk	84	25	9	9	CD
cord-290218-dvyeg5fk	84	26	Structures	structure	NNS
cord-290218-dvyeg5fk	84	27	of	of	IN
cord-290218-dvyeg5fk	84	28	the	the	DT
cord-290218-dvyeg5fk	84	29	SARS	SARS	NNP
cord-290218-dvyeg5fk	84	30	-	-	HYPH
cord-290218-dvyeg5fk	84	31	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	85	1	Endoribonuclease	endoribonuclease	NN
cord-290218-dvyeg5fk	86	1	Nsp15	Nsp15	NNP
cord-290218-dvyeg5fk	87	1	The	the	DT
cord-290218-dvyeg5fk	87	2	crystal	crystal	JJ
cord-290218-dvyeg5fk	87	3	structure	structure	NN
cord-290218-dvyeg5fk	87	4	of	of	IN
cord-290218-dvyeg5fk	87	5	nsp10-nsp16	nsp10-nsp16	NNP
cord-290218-dvyeg5fk	87	6	heterodimer	heterodimer	NN
cord-290218-dvyeg5fk	87	7	from	from	IN
cord-290218-dvyeg5fk	87	8	SARS	SARS	NNP
cord-290218-dvyeg5fk	87	9	-	-	HYPH
cord-290218-dvyeg5fk	87	10	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	87	11	in	in	IN
cord-290218-dvyeg5fk	87	12	complex	complex	NN
cord-290218-dvyeg5fk	87	13	with	with	IN
cord-290218-dvyeg5fk	87	14	S	S	NNP
cord-290218-dvyeg5fk	87	15	-	-	HYPH
cord-290218-dvyeg5fk	87	16	adenosylmethionine	adenosylmethionine	NNP
cord-290218-dvyeg5fk	87	17	One	one	CD
cord-290218-dvyeg5fk	87	18	severe	severe	JJ
cord-290218-dvyeg5fk	87	19	acute	acute	JJ
cord-290218-dvyeg5fk	87	20	respiratory	respiratory	JJ
cord-290218-dvyeg5fk	87	21	syndrome	syndrome	NN
cord-290218-dvyeg5fk	87	22	coronavirus	coronavirus	NN
cord-290218-dvyeg5fk	87	23	protein	protein	NN
cord-290218-dvyeg5fk	87	24	complex	complex	NN
cord-290218-dvyeg5fk	87	25	integrates	integrate	VBZ
cord-290218-dvyeg5fk	87	26	processive	processive	JJ
cord-290218-dvyeg5fk	87	27	RNA	RNA	NNP
cord-290218-dvyeg5fk	87	28	polymerase	polymerase	NN
cord-290218-dvyeg5fk	87	29	and	and	CC
cord-290218-dvyeg5fk	87	30	exonuclease	exonuclease	NN
cord-290218-dvyeg5fk	87	31	activities	activity	NNS
cord-290218-dvyeg5fk	87	32	Structure	Structure	NNP
cord-290218-dvyeg5fk	87	33	of	of	IN
cord-290218-dvyeg5fk	87	34	the	the	DT
cord-290218-dvyeg5fk	87	35	SARS	SARS	NNP
cord-290218-dvyeg5fk	87	36	-	-	HYPH
cord-290218-dvyeg5fk	87	37	CoV	CoV	NNP
cord-290218-dvyeg5fk	87	38	nsp12	nsp12	CD
cord-290218-dvyeg5fk	87	39	polymerase	polymerase	NN
cord-290218-dvyeg5fk	87	40	bound	bind	VBN
cord-290218-dvyeg5fk	87	41	to	to	IN
cord-290218-dvyeg5fk	87	42	nsp7	nsp7	NN
cord-290218-dvyeg5fk	87	43	and	and	CC
cord-290218-dvyeg5fk	87	44	nsp8	nsp8	NN
cord-290218-dvyeg5fk	87	45	co	co	NNS
cord-290218-dvyeg5fk	87	46	-	-	NNS
cord-290218-dvyeg5fk	87	47	factors	factor	NNS
cord-290218-dvyeg5fk	87	48	Emerging	Emerging	NNP
cord-290218-dvyeg5fk	87	49	SARS	SARS	NNP
cord-290218-dvyeg5fk	87	50	-	-	HYPH
cord-290218-dvyeg5fk	87	51	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	87	52	mutation	mutation	NN
cord-290218-dvyeg5fk	87	53	hot	hot	JJ
cord-290218-dvyeg5fk	87	54	spots	spot	NNS
cord-290218-dvyeg5fk	87	55	include	include	VBP
cord-290218-dvyeg5fk	87	56	a	a	DT
cord-290218-dvyeg5fk	87	57	novel	novel	JJ
cord-290218-dvyeg5fk	87	58	RNA	rna	NN
cord-290218-dvyeg5fk	87	59	-	-	HYPH
cord-290218-dvyeg5fk	87	60	dependent	dependent	JJ
cord-290218-dvyeg5fk	87	61	-	-	HYPH
cord-290218-dvyeg5fk	87	62	RNA	rna	NN
cord-290218-dvyeg5fk	87	63	polymerase	polymerase	NN
cord-290218-dvyeg5fk	87	64	variant	variant	NN
cord-290218-dvyeg5fk	87	65	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	87	66	mutations	mutation	NNS
cord-290218-dvyeg5fk	87	67	are	be	VBP
cord-290218-dvyeg5fk	87	68	associated	associate	VBN
cord-290218-dvyeg5fk	87	69	with	with	IN
cord-290218-dvyeg5fk	87	70	SARS	SARS	NNP
cord-290218-dvyeg5fk	87	71	-	-	HYPH
cord-290218-dvyeg5fk	87	72	CoV	CoV	NNP
cord-290218-dvyeg5fk	87	73	Crystal	Crystal	NNP
cord-290218-dvyeg5fk	87	74	structure	structure	NN
cord-290218-dvyeg5fk	87	75	of	of	IN
cord-290218-dvyeg5fk	87	76	Zika	Zika	NNP
cord-290218-dvyeg5fk	87	77	virus	virus	NN
cord-290218-dvyeg5fk	87	78	NS5	NS5	NNP
cord-290218-dvyeg5fk	87	79	RNA	RNA	NNP
cord-290218-dvyeg5fk	87	80	-	-	HYPH
cord-290218-dvyeg5fk	87	81	dependent	dependent	JJ
cord-290218-dvyeg5fk	87	82	RNA	RNA	NNP
cord-290218-dvyeg5fk	87	83	polymerase	polymerase	NN
cord-290218-dvyeg5fk	87	84	Structural	Structural	NNP
cord-290218-dvyeg5fk	87	85	Insights	Insights	NNPS
cord-290218-dvyeg5fk	87	86	into	into	IN
cord-290218-dvyeg5fk	87	87	Bunyavirus	Bunyavirus	NNP
cord-290218-dvyeg5fk	87	88	Replication	Replication	NNP
cord-290218-dvyeg5fk	87	89	and	and	CC
cord-290218-dvyeg5fk	87	90	Its	-PRON-	PRP$
cord-290218-dvyeg5fk	87	91	Regulation	regulation	NN
cord-290218-dvyeg5fk	87	92	by	by	IN
cord-290218-dvyeg5fk	87	93	the	the	DT
cord-290218-dvyeg5fk	87	94	vRNA	vrna	JJ
cord-290218-dvyeg5fk	87	95	Promoter	Promoter	NNP
cord-290218-dvyeg5fk	87	96	Insights	Insights	NNP
cord-290218-dvyeg5fk	87	97	into	into	IN
cord-290218-dvyeg5fk	87	98	SARS	SARS	NNP
cord-290218-dvyeg5fk	87	99	-	-	HYPH
cord-290218-dvyeg5fk	87	100	CoV	CoV	NNP
cord-290218-dvyeg5fk	87	101	transcription	transcription	NN
cord-290218-dvyeg5fk	87	102	and	and	CC
cord-290218-dvyeg5fk	87	103	replication	replication	NN
cord-290218-dvyeg5fk	87	104	from	from	IN
cord-290218-dvyeg5fk	87	105	the	the	DT
cord-290218-dvyeg5fk	87	106	structure	structure	NN
cord-290218-dvyeg5fk	87	107	of	of	IN
cord-290218-dvyeg5fk	87	108	the	the	DT
cord-290218-dvyeg5fk	87	109	nsp7-nsp8	nsp7-nsp8	NNP
cord-290218-dvyeg5fk	87	110	hexadecamer	hexadecamer	NN
cord-290218-dvyeg5fk	87	111	Viral	viral	JJ
cord-290218-dvyeg5fk	87	112	replication	replication	NN
cord-290218-dvyeg5fk	87	113	.	.	.
cord-290218-dvyeg5fk	88	1	Structural	structural	JJ
cord-290218-dvyeg5fk	88	2	basis	basis	NN
cord-290218-dvyeg5fk	88	3	for	for	IN
cord-290218-dvyeg5fk	88	4	RNA	rna	NN
cord-290218-dvyeg5fk	88	5	replication	replication	NN
cord-290218-dvyeg5fk	88	6	by	by	IN
cord-290218-dvyeg5fk	88	7	the	the	DT
cord-290218-dvyeg5fk	88	8	hepatitis	hepatitis	NN
cord-290218-dvyeg5fk	88	9	C	C	NNP
cord-290218-dvyeg5fk	88	10	virus	virus	NN
cord-290218-dvyeg5fk	88	11	polymerase	polymerase	NN
cord-290218-dvyeg5fk	88	12	Structural	structural	JJ
cord-290218-dvyeg5fk	88	13	basis	basis	NN
cord-290218-dvyeg5fk	88	14	for	for	IN
cord-290218-dvyeg5fk	88	15	active	active	JJ
cord-290218-dvyeg5fk	88	16	site	site	NN
cord-290218-dvyeg5fk	88	17	closure	closure	NN
cord-290218-dvyeg5fk	88	18	by	by	IN
cord-290218-dvyeg5fk	88	19	the	the	DT
cord-290218-dvyeg5fk	88	20	poliovirus	poliovirus	NN
cord-290218-dvyeg5fk	88	21	RNA	rna	NN
cord-290218-dvyeg5fk	88	22	-	-	HYPH
cord-290218-dvyeg5fk	88	23	dependent	dependent	JJ
cord-290218-dvyeg5fk	88	24	RNA	RNA	NNP
cord-290218-dvyeg5fk	88	25	polymerase	polymerase	NN
cord-290218-dvyeg5fk	88	26	Allosteric	Allosteric	NNP
cord-290218-dvyeg5fk	88	27	Regulation	Regulation	NNP
cord-290218-dvyeg5fk	88	28	of	of	IN
cord-290218-dvyeg5fk	88	29	RNA	RNA	NNP
cord-290218-dvyeg5fk	88	30	-	-	HYPH
cord-290218-dvyeg5fk	88	31	Dependent	Dependent	NNP
cord-290218-dvyeg5fk	88	32	RNA	RNA	NNP
cord-290218-dvyeg5fk	88	33	Polymerization	Polymerization	NNP
cord-290218-dvyeg5fk	88	34	Activity	Activity	NNP
cord-290218-dvyeg5fk	88	35	Mutation	Mutation	NNP
cord-290218-dvyeg5fk	88	36	analysis	analysis	NN
cord-290218-dvyeg5fk	88	37	of	of	IN
cord-290218-dvyeg5fk	88	38	the	the	DT
cord-290218-dvyeg5fk	88	39	GDD	GDD	NNP
cord-290218-dvyeg5fk	88	40	sequence	sequence	NN
cord-290218-dvyeg5fk	88	41	motif	motif	NN
cord-290218-dvyeg5fk	88	42	of	of	IN
cord-290218-dvyeg5fk	88	43	a	a	DT
cord-290218-dvyeg5fk	88	44	calicivirus	calicivirus	NNP
cord-290218-dvyeg5fk	88	45	RNA	RNA	NNP
cord-290218-dvyeg5fk	88	46	-	-	HYPH
cord-290218-dvyeg5fk	88	47	dependent	dependent	JJ
cord-290218-dvyeg5fk	88	48	RNA	RNA	NNP
cord-290218-dvyeg5fk	88	49	polymerase	polymerase	NN
cord-290218-dvyeg5fk	88	50	Mutational	Mutational	NNP
cord-290218-dvyeg5fk	88	51	analysis	analysis	NN
cord-290218-dvyeg5fk	88	52	of	of	IN
cord-290218-dvyeg5fk	88	53	the	the	DT
cord-290218-dvyeg5fk	88	54	GDD	GDD	NNP
cord-290218-dvyeg5fk	88	55	sequence	sequence	NN
cord-290218-dvyeg5fk	88	56	motif	motif	NN
cord-290218-dvyeg5fk	88	57	of	of	IN
cord-290218-dvyeg5fk	88	58	classical	classical	JJ
cord-290218-dvyeg5fk	88	59	swine	swine	NN
cord-290218-dvyeg5fk	88	60	fever	fever	NN
cord-290218-dvyeg5fk	88	61	virus	virus	NN
cord-290218-dvyeg5fk	88	62	RNA	rna	NN
cord-290218-dvyeg5fk	88	63	-	-	HYPH
cord-290218-dvyeg5fk	88	64	dependent	dependent	JJ
cord-290218-dvyeg5fk	88	65	RNA	RNA	NNP
cord-290218-dvyeg5fk	88	66	polymerases	polymerase	NNS
cord-290218-dvyeg5fk	88	67	Structure	Structure	NNP
cord-290218-dvyeg5fk	88	68	of	of	IN
cord-290218-dvyeg5fk	88	69	replicating	replicate	VBG
cord-290218-dvyeg5fk	88	70	SARS	SARS	NNP
cord-290218-dvyeg5fk	88	71	-	-	HYPH
cord-290218-dvyeg5fk	88	72	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	88	73	polymerase	polymerase	NN
cord-290218-dvyeg5fk	88	74	Nidovirus	Nidovirus	NNP
cord-290218-dvyeg5fk	88	75	RNA	RNA	NNP
cord-290218-dvyeg5fk	88	76	polymerases	polymerase	NNS
cord-290218-dvyeg5fk	88	77	:	:	:
cord-290218-dvyeg5fk	89	1	Complex	complex	JJ
cord-290218-dvyeg5fk	89	2	enzymes	enzyme	NNS
cord-290218-dvyeg5fk	89	3	handling	handle	VBG
cord-290218-dvyeg5fk	89	4	exceptional	exceptional	JJ
cord-290218-dvyeg5fk	89	5	RNA	RNA	NNP
cord-290218-dvyeg5fk	89	6	genomes	genome	NNS
cord-290218-dvyeg5fk	89	7	Structural	structural	JJ
cord-290218-dvyeg5fk	89	8	basis	basis	NN
cord-290218-dvyeg5fk	89	9	for	for	IN
cord-290218-dvyeg5fk	89	10	helicase	helicase	NN
cord-290218-dvyeg5fk	89	11	-	-	HYPH
cord-290218-dvyeg5fk	89	12	polymerase	polymerase	NN
cord-290218-dvyeg5fk	89	13	coupling	coupling	NN
cord-290218-dvyeg5fk	89	14	in	in	IN
cord-290218-dvyeg5fk	89	15	the	the	DT
cord-290218-dvyeg5fk	89	16	SARS	SARS	NNP
cord-290218-dvyeg5fk	89	17	-	-	HYPH
cord-290218-dvyeg5fk	89	18	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	89	19	replication	replication	NN
cord-290218-dvyeg5fk	89	20	-	-	HYPH
cord-290218-dvyeg5fk	89	21	transcription	transcription	NN
cord-290218-dvyeg5fk	89	22	complex	complex	NN
cord-290218-dvyeg5fk	90	1	Will	Will	MD
cord-290218-dvyeg5fk	90	2	There	there	EX
cord-290218-dvyeg5fk	90	3	Be	be	VB
cord-290218-dvyeg5fk	90	4	a	a	DT
cord-290218-dvyeg5fk	90	5	Cure	cure	NN
cord-290218-dvyeg5fk	90	6	for	for	IN
cord-290218-dvyeg5fk	90	7	Ebola	Ebola	NNP
cord-290218-dvyeg5fk	90	8	?	?	.
cord-290218-dvyeg5fk	91	1	Remdesivir	Remdesivir	NNP
cord-290218-dvyeg5fk	91	2	is	be	VBZ
cord-290218-dvyeg5fk	91	3	a	a	DT
cord-290218-dvyeg5fk	91	4	direct	direct	JJ
cord-290218-dvyeg5fk	91	5	-	-	HYPH
cord-290218-dvyeg5fk	91	6	acting	act	VBG
cord-290218-dvyeg5fk	91	7	antiviral	antiviral	JJ
cord-290218-dvyeg5fk	91	8	that	that	WDT
cord-290218-dvyeg5fk	91	9	inhibits	inhibit	VBZ
cord-290218-dvyeg5fk	91	10	RNA	rna	NN
cord-290218-dvyeg5fk	91	11	-	-	HYPH
cord-290218-dvyeg5fk	91	12	dependent	dependent	JJ
cord-290218-dvyeg5fk	91	13	RNA	RNA	NNP
cord-290218-dvyeg5fk	91	14	polymerase	polymerase	NN
cord-290218-dvyeg5fk	91	15	from	from	IN
cord-290218-dvyeg5fk	91	16	severe	severe	JJ
cord-290218-dvyeg5fk	91	17	acute	acute	JJ
cord-290218-dvyeg5fk	91	18	respiratory	respiratory	JJ
cord-290218-dvyeg5fk	91	19	syndrome	syndrome	NN
cord-290218-dvyeg5fk	91	20	coronavirus	coronavirus	NN
cord-290218-dvyeg5fk	91	21	2	2	CD
cord-290218-dvyeg5fk	91	22	with	with	IN
cord-290218-dvyeg5fk	91	23	high	high	JJ
cord-290218-dvyeg5fk	91	24	potency	potency	NN
cord-290218-dvyeg5fk	91	25	High	high	JJ
cord-290218-dvyeg5fk	91	26	-	-	HYPH
cord-290218-dvyeg5fk	91	27	throughput	throughput	NN
cord-290218-dvyeg5fk	91	28	screening	screening	NN
cord-290218-dvyeg5fk	91	29	identification	identification	NN
cord-290218-dvyeg5fk	91	30	of	of	IN
cord-290218-dvyeg5fk	91	31	poliovirus	poliovirus	NN
cord-290218-dvyeg5fk	91	32	RNA	rna	NN
cord-290218-dvyeg5fk	91	33	-	-	HYPH
cord-290218-dvyeg5fk	91	34	dependent	dependent	JJ
cord-290218-dvyeg5fk	91	35	RNA	RNA	NNP
cord-290218-dvyeg5fk	91	36	polymerase	polymerase	NN
cord-290218-dvyeg5fk	92	1	inhibitors	inhibitor	NNS
cord-290218-dvyeg5fk	92	2	Favipiravir	Favipiravir	NNP
cord-290218-dvyeg5fk	92	3	:	:	:
cord-290218-dvyeg5fk	93	1	Pharmacokinetics	Pharmacokinetics	NNP
cord-290218-dvyeg5fk	93	2	and	and	CC
cord-290218-dvyeg5fk	93	3	Concerns	concern	NNS
cord-290218-dvyeg5fk	93	4	About	about	IN
cord-290218-dvyeg5fk	93	5	Clinical	Clinical	NNP
cord-290218-dvyeg5fk	93	6	Trials	trial	NNS
cord-290218-dvyeg5fk	93	7	for	for	IN
cord-290218-dvyeg5fk	93	8	2019-nCoV	2019-ncov	CD
cord-290218-dvyeg5fk	93	9	Infection	Infection	NNP
cord-290218-dvyeg5fk	93	10	Analysis	Analysis	NNP
cord-290218-dvyeg5fk	93	11	of	of	IN
cord-290218-dvyeg5fk	93	12	therapeutic	therapeutic	JJ
cord-290218-dvyeg5fk	93	13	targets	target	NNS
cord-290218-dvyeg5fk	93	14	for	for	IN
cord-290218-dvyeg5fk	93	15	SARS	SARS	NNP
cord-290218-dvyeg5fk	93	16	-	-	HYPH
cord-290218-dvyeg5fk	93	17	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	93	18	and	and	CC
cord-290218-dvyeg5fk	93	19	discovery	discovery	NN
cord-290218-dvyeg5fk	93	20	of	of	IN
cord-290218-dvyeg5fk	93	21	potential	potential	JJ
cord-290218-dvyeg5fk	93	22	drugs	drug	NNS
cord-290218-dvyeg5fk	93	23	by	by	IN
cord-290218-dvyeg5fk	93	24	computational	computational	JJ
cord-290218-dvyeg5fk	93	25	methods	method	NNS
cord-290218-dvyeg5fk	93	26	High	high	RB
cord-290218-dvyeg5fk	93	27	throughput	throughput	NN
cord-290218-dvyeg5fk	93	28	virtual	virtual	JJ
cord-290218-dvyeg5fk	93	29	screening	screening	NN
cord-290218-dvyeg5fk	93	30	reveals	reveal	VBZ
cord-290218-dvyeg5fk	93	31	SARS	SARS	NNP
cord-290218-dvyeg5fk	93	32	-	-	HYPH
cord-290218-dvyeg5fk	93	33	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	93	34	multi	multi	JJ
cord-290218-dvyeg5fk	93	35	-	-	JJ
cord-290218-dvyeg5fk	93	36	target	target	JJ
cord-290218-dvyeg5fk	93	37	binding	bind	VBG
cord-290218-dvyeg5fk	93	38	natural	natural	JJ
cord-290218-dvyeg5fk	93	39	compounds	compound	NNS
cord-290218-dvyeg5fk	93	40	to	to	TO
cord-290218-dvyeg5fk	93	41	lead	lead	VB
cord-290218-dvyeg5fk	93	42	instant	instant	JJ
cord-290218-dvyeg5fk	93	43	therapy	therapy	NN
cord-290218-dvyeg5fk	93	44	for	for	IN
cord-290218-dvyeg5fk	93	45	COVID-19	COVID-19	NNP
cord-290218-dvyeg5fk	93	46	treatment	treatment	NN
cord-290218-dvyeg5fk	93	47	SARS	SARS	NNP
cord-290218-dvyeg5fk	93	48	-	-	HYPH
cord-290218-dvyeg5fk	93	49	CoV-2	CoV-2	NNP
cord-290218-dvyeg5fk	93	50	RNA	RNA	NNP
cord-290218-dvyeg5fk	94	1	dependent	dependent	JJ
cord-290218-dvyeg5fk	94	2	RNA	RNA	NNP
cord-290218-dvyeg5fk	94	3	polymerase	polymerase	NN
cord-290218-dvyeg5fk	94	4	(	(	-LRB-
cord-290218-dvyeg5fk	94	5	RdRp	RdRp	NNP
cord-290218-dvyeg5fk	94	6	)	)	-RRB-
cord-290218-dvyeg5fk	94	7	targeting	target	VBG
cord-290218-dvyeg5fk	94	8	:	:	:
cord-290218-dvyeg5fk	94	9	an	an	DT
cord-290218-dvyeg5fk	94	10	in	in	IN
cord-290218-dvyeg5fk	94	11	silico	silico	NN
cord-290218-dvyeg5fk	94	12	perspective	perspective	NN
cord-290218-dvyeg5fk	95	1	All	all	DT
cord-290218-dvyeg5fk	95	2	third	third	JJ
cord-290218-dvyeg5fk	95	3	-	-	HYPH
cord-290218-dvyeg5fk	95	4	party	party	NN
cord-290218-dvyeg5fk	95	5	financial	financial	JJ
cord-290218-dvyeg5fk	95	6	support	support	NN
cord-290218-dvyeg5fk	95	7	for	for	IN
cord-290218-dvyeg5fk	95	8	the	the	DT
cord-290218-dvyeg5fk	95	9	work	work	NN
cord-290218-dvyeg5fk	95	10	in	in	IN
cord-290218-dvyeg5fk	95	11	the	the	DT
cord-290218-dvyeg5fk	95	12	submitted	submit	VBN
cord-290218-dvyeg5fk	95	13	manuscript	manuscript	NN
cord-290218-dvyeg5fk	96	1	All	all	DT
cord-290218-dvyeg5fk	96	2	financial	financial	JJ
cord-290218-dvyeg5fk	96	3	relationships	relationship	NNS
cord-290218-dvyeg5fk	96	4	with	with	IN
cord-290218-dvyeg5fk	96	5	any	any	DT
cord-290218-dvyeg5fk	96	6	entities	entity	NNS
cord-290218-dvyeg5fk	96	7	that	that	WDT
cord-290218-dvyeg5fk	96	8	could	could	MD
cord-290218-dvyeg5fk	96	9	be	be	VB
cord-290218-dvyeg5fk	96	10	viewed	view	VBN
cord-290218-dvyeg5fk	96	11	as	as	IN
cord-290218-dvyeg5fk	96	12	relevant	relevant	JJ
cord-290218-dvyeg5fk	96	13	to	to	IN
cord-290218-dvyeg5fk	96	14	the	the	DT
cord-290218-dvyeg5fk	96	15	general	general	JJ
cord-290218-dvyeg5fk	96	16	area	area	NN
cord-290218-dvyeg5fk	96	17	of	of	IN
cord-290218-dvyeg5fk	96	18	the	the	DT
cord-290218-dvyeg5fk	96	19	submitted	submit	VBN
cord-290218-dvyeg5fk	96	20	manuscript	manuscript	NN
cord-290218-dvyeg5fk	97	1	All	all	DT
cord-290218-dvyeg5fk	97	2	sources	source	NNS
cord-290218-dvyeg5fk	97	3	of	of	IN
cord-290218-dvyeg5fk	97	4	revenue	revenue	NN
cord-290218-dvyeg5fk	97	5	with	with	IN
cord-290218-dvyeg5fk	97	6	relevance	relevance	NN
cord-290218-dvyeg5fk	97	7	to	to	IN
cord-290218-dvyeg5fk	97	8	the	the	DT
cord-290218-dvyeg5fk	97	9	submitted	submit	VBN
cord-290218-dvyeg5fk	97	10	work	work	NN
cord-290218-dvyeg5fk	97	11	who	who	WP
cord-290218-dvyeg5fk	97	12	made	make	VBD
cord-290218-dvyeg5fk	97	13	payments	payment	NNS
cord-290218-dvyeg5fk	97	14	to	to	IN
cord-290218-dvyeg5fk	97	15	you	-PRON-	PRP
cord-290218-dvyeg5fk	97	16	,	,	,
cord-290218-dvyeg5fk	97	17	or	or	CC
cord-290218-dvyeg5fk	97	18	to	to	IN
cord-290218-dvyeg5fk	97	19	your	-PRON-	PRP$
cord-290218-dvyeg5fk	97	20	institution	institution	NN
cord-290218-dvyeg5fk	97	21	on	on	IN
cord-290218-dvyeg5fk	97	22	your	-PRON-	PRP$
cord-290218-dvyeg5fk	97	23	behalf	behalf	NN
cord-290218-dvyeg5fk	97	24	Any	any	DT
cord-290218-dvyeg5fk	97	25	other	other	JJ
cord-290218-dvyeg5fk	97	26	interactions	interaction	NNS
cord-290218-dvyeg5fk	97	27	with	with	IN
cord-290218-dvyeg5fk	97	28	the	the	DT
cord-290218-dvyeg5fk	97	29	sponsor	sponsor	NN
cord-290218-dvyeg5fk	97	30	of	of	IN
cord-290218-dvyeg5fk	97	31	outside	outside	NN
cord-290218-dvyeg5fk	97	32	of	of	IN
cord-290218-dvyeg5fk	97	33	the	the	DT
cord-290218-dvyeg5fk	97	34	submitted	submit	VBN
cord-290218-dvyeg5fk	97	35	work	work	NN
cord-290218-dvyeg5fk	97	36	should	should	MD
cord-290218-dvyeg5fk	97	37	also	also	RB
cord-290218-dvyeg5fk	97	38	be	be	VB
cord-290218-dvyeg5fk	97	39	reported	report	VBN
cord-290218-dvyeg5fk	97	40	.	.	.
cord-290218-dvyeg5fk	98	1	(	(	-LRB-
cord-290218-dvyeg5fk	98	2	5	5	LS
cord-290218-dvyeg5fk	98	3	)	)	-RRB-
cord-290218-dvyeg5fk	99	1	Any	any	DT
cord-290218-dvyeg5fk	99	2	relevant	relevant	JJ
cord-290218-dvyeg5fk	99	3	patents	patent	NNS
cord-290218-dvyeg5fk	99	4	or	or	CC
cord-290218-dvyeg5fk	99	5	copyrights	copyright	NNS
cord-290218-dvyeg5fk	99	6	(	(	-LRB-
cord-290218-dvyeg5fk	99	7	planned	plan	VBN
cord-290218-dvyeg5fk	99	8	,	,	,
cord-290218-dvyeg5fk	99	9	pending	pende	VBG
cord-290218-dvyeg5fk	99	10	,	,	,
cord-290218-dvyeg5fk	99	11	or	or	CC
cord-290218-dvyeg5fk	99	12	issued	issue	VBN
cord-290218-dvyeg5fk	99	13	)	)	-RRB-
cord-290218-dvyeg5fk	100	1	Any	any	DT
cord-290218-dvyeg5fk	100	2	other	other	JJ
cord-290218-dvyeg5fk	100	3	relationships	relationship	NNS
cord-290218-dvyeg5fk	100	4	or	or	CC
cord-290218-dvyeg5fk	100	5	affiliations	affiliation	NNS
cord-290218-dvyeg5fk	100	6	that	that	WDT
cord-290218-dvyeg5fk	100	7	may	may	MD
cord-290218-dvyeg5fk	100	8	be	be	VB
cord-290218-dvyeg5fk	100	9	perceived	perceive	VBN
cord-290218-dvyeg5fk	100	10	by	by	IN
cord-290218-dvyeg5fk	100	11	readers	reader	NNS
cord-290218-dvyeg5fk	100	12	to	to	TO
cord-290218-dvyeg5fk	100	13	have	have	VB
cord-290218-dvyeg5fk	100	14	influenced	influence	VBN
cord-290218-dvyeg5fk	100	15	,	,	,
cord-290218-dvyeg5fk	100	16	or	or	CC
cord-290218-dvyeg5fk	100	17	give	give	VB
cord-290218-dvyeg5fk	100	18	the	the	DT
cord-290218-dvyeg5fk	100	19	appearance	appearance	NN
cord-290218-dvyeg5fk	100	20	of	of	IN
cord-290218-dvyeg5fk	100	21	potentially	potentially	RB
cord-290218-dvyeg5fk	100	22	influencing	influence	VBG
cord-290218-dvyeg5fk	100	23	,	,	,
cord-290218-dvyeg5fk	100	24	what	what	WP
cord-290218-dvyeg5fk	100	25	you	-PRON-	PRP
cord-290218-dvyeg5fk	100	26	wrote	write	VBD
cord-290218-dvyeg5fk	100	27	in	in	IN
cord-290218-dvyeg5fk	100	28	the	the	DT
cord-290218-dvyeg5fk	100	29	submitted	submit	VBN
cord-290218-dvyeg5fk	100	30	work	work	NN
cord-290218-dvyeg5fk	100	31	.	.	.
cord-290218-dvyeg5fk	101	1	As	as	IN
cord-290218-dvyeg5fk	101	2	a	a	DT
cord-290218-dvyeg5fk	101	3	general	general	JJ
cord-290218-dvyeg5fk	101	4	guideline	guideline	NN