id	sid	tid	token	lemma	pos
cord-256918-mauzesor	1	1	key	key	NN
cord-256918-mauzesor	1	2	:	:	:
cord-256918-mauzesor	1	3	cord-256918-mauzesor	cord-256918-mauzesor	ADD
cord-256918-mauzesor	2	1	authors	author	NNS
cord-256918-mauzesor	2	2	:	:	:
cord-256918-mauzesor	2	3	Domingo	Domingo	NNP
cord-256918-mauzesor	3	1	,	,	,
cord-256918-mauzesor	3	2	Esteban	Esteban	NNP
cord-256918-mauzesor	3	3	title	title	NN
cord-256918-mauzesor	3	4	:	:	:
cord-256918-mauzesor	4	1	Quasispecies	quasispecie	NNS
cord-256918-mauzesor	4	2	and	and	CC
cord-256918-mauzesor	4	3	the	the	DT
cord-256918-mauzesor	4	4	implications	implication	NNS
cord-256918-mauzesor	4	5	for	for	IN
cord-256918-mauzesor	4	6	virus	virus	NN
cord-256918-mauzesor	4	7	persistence	persistence	NN
cord-256918-mauzesor	4	8	and	and	CC
cord-256918-mauzesor	4	9	escape	escape	VB
cord-256918-mauzesor	4	10	date	date	NN
cord-256918-mauzesor	4	11	:	:	:
cord-256918-mauzesor	4	12	1998	1998	CD
cord-256918-mauzesor	4	13	-	-	HYPH
cord-256918-mauzesor	4	14	07	07	CD
cord-256918-mauzesor	4	15	-	-	SYM
cord-256918-mauzesor	4	16	15	15	CD
cord-256918-mauzesor	4	17	journal	journal	NN
cord-256918-mauzesor	4	18	:	:	:
cord-256918-mauzesor	4	19	Clinical	clinical	JJ
cord-256918-mauzesor	4	20	and	and	CC
cord-256918-mauzesor	4	21	Diagnostic	Diagnostic	NNP
cord-256918-mauzesor	4	22	Virology	Virology	NNP
cord-256918-mauzesor	4	23	DOI	DOI	NNP
cord-256918-mauzesor	4	24	:	:	:
cord-256918-mauzesor	4	25	10.1016	10.1016	CD
cord-256918-mauzesor	4	26	/	/	SYM
cord-256918-mauzesor	4	27	s0928	s0928	NNP
cord-256918-mauzesor	4	28	-	-	HYPH
cord-256918-mauzesor	4	29	0197(98)00032	0197(98)00032	CD
cord-256918-mauzesor	4	30	-	-	HYPH
cord-256918-mauzesor	4	31	4	4	CD
cord-256918-mauzesor	4	32	sha	sha	NNP
cord-256918-mauzesor	4	33	:	:	:
cord-256918-mauzesor	4	34	93a9ce5dc65920bc235049037d9c03b211395c57	93a9ce5dc65920bc235049037d9c03b211395c57	CD
cord-256918-mauzesor	4	35	doc_id	doc_id	CD
cord-256918-mauzesor	4	36	:	:	:
cord-256918-mauzesor	4	37	256918	256918	CD
cord-256918-mauzesor	4	38	cord_uid	cord_uid	NNS
cord-256918-mauzesor	4	39	:	:	:
cord-256918-mauzesor	5	1	mauzesor	mauzesor	NNP
cord-256918-mauzesor	5	2	Abstract	Abstract	NNP
cord-256918-mauzesor	5	3	Background	Background	NNP
cord-256918-mauzesor	5	4	:	:	:
cord-256918-mauzesor	5	5	In	in	IN
cord-256918-mauzesor	5	6	the	the	DT
cord-256918-mauzesor	5	7	1970s	1970s	CD
cord-256918-mauzesor	5	8	Manfred	Manfred	NNP
cord-256918-mauzesor	5	9	Eigen	Eigen	NNP
cord-256918-mauzesor	5	10	and	and	CC
cord-256918-mauzesor	5	11	colleagues	colleague	NNS
cord-256918-mauzesor	5	12	proposed	propose	VBD
cord-256918-mauzesor	5	13	a	a	DT
cord-256918-mauzesor	5	14	new	new	JJ
cord-256918-mauzesor	5	15	model	model	NN
cord-256918-mauzesor	5	16	of	of	IN
cord-256918-mauzesor	5	17	molecular	molecular	JJ
cord-256918-mauzesor	5	18	evolution	evolution	NN
cord-256918-mauzesor	5	19	to	to	TO
cord-256918-mauzesor	5	20	explain	explain	VB
cord-256918-mauzesor	5	21	adaptability	adaptability	NN
cord-256918-mauzesor	5	22	and	and	CC
cord-256918-mauzesor	5	23	rapid	rapid	JJ
cord-256918-mauzesor	5	24	evolution	evolution	NN
cord-256918-mauzesor	5	25	of	of	IN
cord-256918-mauzesor	5	26	simple	simple	JJ
cord-256918-mauzesor	5	27	replicons	replicon	NNS
cord-256918-mauzesor	5	28	,	,	,
cord-256918-mauzesor	5	29	as	as	IN
cord-256918-mauzesor	5	30	those	those	DT
cord-256918-mauzesor	5	31	that	that	WDT
cord-256918-mauzesor	5	32	probably	probably	RB
cord-256918-mauzesor	5	33	populated	populate	VBD
cord-256918-mauzesor	5	34	the	the	DT
cord-256918-mauzesor	5	35	earth	earth	NN
cord-256918-mauzesor	5	36	at	at	IN
cord-256918-mauzesor	5	37	the	the	DT
cord-256918-mauzesor	5	38	onset	onset	NN
cord-256918-mauzesor	5	39	of	of	IN
cord-256918-mauzesor	5	40	life	life	NN
cord-256918-mauzesor	5	41	.	.	.
cord-256918-mauzesor	6	1	This	this	DT
cord-256918-mauzesor	6	2	model	model	NN
cord-256918-mauzesor	6	3	of	of	IN
cord-256918-mauzesor	6	4	evolution	evolution	NN
cord-256918-mauzesor	6	5	placed	place	VBD
cord-256918-mauzesor	6	6	emphasis	emphasis	NN
cord-256918-mauzesor	6	7	on	on	IN
cord-256918-mauzesor	6	8	mutant	mutant	JJ
cord-256918-mauzesor	6	9	generation	generation	NN
cord-256918-mauzesor	6	10	,	,	,
cord-256918-mauzesor	6	11	to	to	IN
cord-256918-mauzesor	6	12	the	the	DT
cord-256918-mauzesor	6	13	point	point	NN
cord-256918-mauzesor	6	14	of	of	IN
cord-256918-mauzesor	6	15	invalidating	invalidate	VBG
cord-256918-mauzesor	6	16	the	the	DT
cord-256918-mauzesor	6	17	concept	concept	NN
cord-256918-mauzesor	6	18	of	of	IN
cord-256918-mauzesor	6	19	wild	wild	JJ
cord-256918-mauzesor	6	20	-	-	HYPH
cord-256918-mauzesor	6	21	type	type	NN
cord-256918-mauzesor	6	22	genomes	genome	NNS
cord-256918-mauzesor	6	23	as	as	IN
cord-256918-mauzesor	6	24	a	a	DT
cord-256918-mauzesor	6	25	defined	define	VBN
cord-256918-mauzesor	6	26	sequence	sequence	NN
cord-256918-mauzesor	6	27	of	of	IN
cord-256918-mauzesor	6	28	nucleotides	nucleotide	NNS
cord-256918-mauzesor	6	29	.	.	.
cord-256918-mauzesor	7	1	In	in	IN
cord-256918-mauzesor	7	2	striking	striking	JJ
cord-256918-mauzesor	7	3	similarity	similarity	NN
cord-256918-mauzesor	7	4	with	with	IN
cord-256918-mauzesor	7	5	the	the	DT
cord-256918-mauzesor	7	6	proposals	proposal	NNS
cord-256918-mauzesor	7	7	for	for	IN
cord-256918-mauzesor	7	8	such	such	JJ
cord-256918-mauzesor	7	9	early	early	JJ
cord-256918-mauzesor	7	10	replicons	replicon	NNS
cord-256918-mauzesor	7	11	,	,	,
cord-256918-mauzesor	7	12	present	present	JJ
cord-256918-mauzesor	7	13	-	-	HYPH
cord-256918-mauzesor	7	14	day	day	NN
cord-256918-mauzesor	7	15	RNA	RNA	NNP
cord-256918-mauzesor	7	16	viruses	virus	NNS
cord-256918-mauzesor	7	17	consist	consist	VBP
cord-256918-mauzesor	7	18	of	of	IN
cord-256918-mauzesor	7	19	complex	complex	JJ
cord-256918-mauzesor	7	20	distributions	distribution	NNS
cord-256918-mauzesor	7	21	of	of	IN
cord-256918-mauzesor	7	22	nonidentical	nonidentical	JJ
cord-256918-mauzesor	7	23	but	but	CC
cord-256918-mauzesor	7	24	closely	closely	RB
cord-256918-mauzesor	7	25	related	related	JJ
cord-256918-mauzesor	7	26	genomes	genome	NNS
cord-256918-mauzesor	7	27	termed	term	VBD
cord-256918-mauzesor	7	28	quasispecies	quasispecie	NNS
cord-256918-mauzesor	7	29	.	.	.
cord-256918-mauzesor	8	1	Objectives	objective	NNS
cord-256918-mauzesor	8	2	:	:	:
cord-256918-mauzesor	8	3	To	to	TO
cord-256918-mauzesor	8	4	discuss	discuss	VB
cord-256918-mauzesor	8	5	indeterminations	indetermination	NNS
cord-256918-mauzesor	8	6	inherent	inherent	JJ
cord-256918-mauzesor	8	7	to	to	IN
cord-256918-mauzesor	8	8	a	a	DT
cord-256918-mauzesor	8	9	quasispecies	quasispecie	NNS
cord-256918-mauzesor	8	10	structure	structure	NN
cord-256918-mauzesor	8	11	and	and	CC
cord-256918-mauzesor	8	12	to	to	IN
cord-256918-mauzesor	8	13	the	the	DT
cord-256918-mauzesor	8	14	analytical	analytical	JJ
cord-256918-mauzesor	8	15	procedures	procedure	NNS
cord-256918-mauzesor	8	16	to	to	TO
cord-256918-mauzesor	8	17	define	define	VB
cord-256918-mauzesor	8	18	it	-PRON-	PRP
cord-256918-mauzesor	8	19	,	,	,
cord-256918-mauzesor	8	20	biological	biological	JJ
cord-256918-mauzesor	8	21	implications	implication	NNS
cord-256918-mauzesor	8	22	of	of	IN
cord-256918-mauzesor	8	23	quasispecies	quasispecie	NNS
cord-256918-mauzesor	8	24	,	,	,
cord-256918-mauzesor	8	25	and	and	CC
cord-256918-mauzesor	8	26	the	the	DT
cord-256918-mauzesor	8	27	need	need	NN
cord-256918-mauzesor	8	28	to	to	TO
cord-256918-mauzesor	8	29	take	take	VB
cord-256918-mauzesor	8	30	into	into	IN
cord-256918-mauzesor	8	31	account	account	NN
cord-256918-mauzesor	8	32	this	this	DT
cord-256918-mauzesor	8	33	type	type	NN
cord-256918-mauzesor	8	34	of	of	IN
cord-256918-mauzesor	8	35	population	population	NN
cord-256918-mauzesor	8	36	structure	structure	NN
cord-256918-mauzesor	8	37	,	,	,
cord-256918-mauzesor	8	38	in	in	IN
cord-256918-mauzesor	8	39	order	order	NN
cord-256918-mauzesor	8	40	to	to	TO
cord-256918-mauzesor	8	41	design	design	VB
cord-256918-mauzesor	8	42	effective	effective	JJ
cord-256918-mauzesor	8	43	strategies	strategy	NNS
cord-256918-mauzesor	8	44	to	to	TO
cord-256918-mauzesor	8	45	prevent	prevent	VB
cord-256918-mauzesor	8	46	and	and	CC
cord-256918-mauzesor	8	47	control	control	NN
cord-256918-mauzesor	8	48	diseases	disease	NNS
cord-256918-mauzesor	8	49	caused	cause	VBN
cord-256918-mauzesor	8	50	by	by	IN
cord-256918-mauzesor	8	51	highly	highly	RB
cord-256918-mauzesor	8	52	variable	variable	JJ
cord-256918-mauzesor	8	53	viruses	virus	NNS
cord-256918-mauzesor	8	54	.	.	.
cord-256918-mauzesor	9	1	Results	result	NNS
cord-256918-mauzesor	9	2	:	:	:
cord-256918-mauzesor	10	1	Quasispecies	quasispecie	NNS
cord-256918-mauzesor	10	2	have	have	VBP
cord-256918-mauzesor	10	3	many	many	JJ
cord-256918-mauzesor	10	4	biological	biological	JJ
cord-256918-mauzesor	10	5	implications	implication	NNS
cord-256918-mauzesor	10	6	,	,	,
cord-256918-mauzesor	10	7	extending	extend	VBG
cord-256918-mauzesor	10	8	from	from	IN
cord-256918-mauzesor	10	9	viral	viral	JJ
cord-256918-mauzesor	10	10	pathogenesis	pathogenesis	NN
cord-256918-mauzesor	10	11	to	to	IN
cord-256918-mauzesor	10	12	the	the	DT
cord-256918-mauzesor	10	13	emergence	emergence	NN
cord-256918-mauzesor	10	14	of	of	IN
cord-256918-mauzesor	10	15	new	new	JJ
cord-256918-mauzesor	10	16	pathogens	pathogen	NNS
cord-256918-mauzesor	10	17	,	,	,
cord-256918-mauzesor	10	18	rapid	rapid	JJ
cord-256918-mauzesor	10	19	antigenic	antigenic	JJ
cord-256918-mauzesor	10	20	variation	variation	NN
cord-256918-mauzesor	10	21	,	,	,
cord-256918-mauzesor	10	22	and	and	CC
cord-256918-mauzesor	10	23	alterations	alteration	NNS
cord-256918-mauzesor	10	24	in	in	IN
cord-256918-mauzesor	10	25	cell	cell	NN
cord-256918-mauzesor	10	26	tropism	tropism	NN
cord-256918-mauzesor	10	27	,	,	,
cord-256918-mauzesor	10	28	virulence	virulence	NN
cord-256918-mauzesor	10	29	,	,	,
cord-256918-mauzesor	10	30	host	host	NN
cord-256918-mauzesor	10	31	range	range	NN
cord-256918-mauzesor	10	32	and	and	CC
cord-256918-mauzesor	10	33	viral	viral	JJ
cord-256918-mauzesor	10	34	gene	gene	NN
cord-256918-mauzesor	10	35	expression	expression	NN
cord-256918-mauzesor	10	36	.	.	.
cord-256918-mauzesor	11	1	Conclusions	conclusion	NNS
cord-256918-mauzesor	11	2	:	:	:
cord-256918-mauzesor	12	1	Diseases	disease	NNS
cord-256918-mauzesor	12	2	caused	cause	VBN
cord-256918-mauzesor	12	3	by	by	IN
cord-256918-mauzesor	12	4	highly	highly	RB
cord-256918-mauzesor	12	5	variable	variable	JJ
cord-256918-mauzesor	12	6	RNA	rna	NN
cord-256918-mauzesor	12	7	viruses	virus	NNS
cord-256918-mauzesor	12	8	prove	prove	VBP
cord-256918-mauzesor	12	9	very	very	RB
cord-256918-mauzesor	12	10	difficult	difficult	JJ
cord-256918-mauzesor	12	11	to	to	TO
cord-256918-mauzesor	12	12	control	control	VB
cord-256918-mauzesor	12	13	and	and	CC
cord-256918-mauzesor	12	14	vaccine	vaccine	NN
cord-256918-mauzesor	12	15	development	development	NN
cord-256918-mauzesor	12	16	against	against	IN
cord-256918-mauzesor	12	17	such	such	JJ
cord-256918-mauzesor	12	18	viruses	virus	NNS
cord-256918-mauzesor	12	19	are	be	VBP
cord-256918-mauzesor	12	20	largely	largely	RB
cord-256918-mauzesor	12	21	unsuccessful	unsuccessful	JJ
cord-256918-mauzesor	12	22	.	.	.
cord-256918-mauzesor	13	1	It	-PRON-	PRP
cord-256918-mauzesor	13	2	is	be	VBZ
cord-256918-mauzesor	13	3	important	important	JJ
cord-256918-mauzesor	13	4	to	to	TO
cord-256918-mauzesor	13	5	understand	understand	VB
cord-256918-mauzesor	13	6	quasispecies	quasispecie	NNS
cord-256918-mauzesor	13	7	composition	composition	NN
cord-256918-mauzesor	13	8	and	and	CC
cord-256918-mauzesor	13	9	dynamics	dynamic	NNS
cord-256918-mauzesor	13	10	,	,	,
cord-256918-mauzesor	13	11	as	as	IN
cord-256918-mauzesor	13	12	quasispecies	quasispecie	NNS
cord-256918-mauzesor	13	13	are	be	VBP
cord-256918-mauzesor	13	14	an	an	DT
cord-256918-mauzesor	13	15	important	important	JJ
cord-256918-mauzesor	13	16	step	step	NN
cord-256918-mauzesor	13	17	in	in	IN
cord-256918-mauzesor	13	18	the	the	DT
cord-256918-mauzesor	13	19	natural	natural	JJ
cord-256918-mauzesor	13	20	history	history	NN
cord-256918-mauzesor	13	21	of	of	IN
cord-256918-mauzesor	13	22	RNA	RNA	NNP
cord-256918-mauzesor	13	23	viruses	virus	NNS
cord-256918-mauzesor	13	24	.	.	.
cord-256918-mauzesor	14	1	Quasispecies	Quasispecies	NNP
cord-256918-mauzesor	14	2	defines	define	VBZ
cord-256918-mauzesor	14	3	a	a	DT
cord-256918-mauzesor	14	4	genetic	genetic	JJ
cord-256918-mauzesor	14	5	organisation	organisation	NN
cord-256918-mauzesor	14	6	of	of	IN
cord-256918-mauzesor	14	7	simple	simple	JJ
cord-256918-mauzesor	14	8	replicons	replicon	NNS
cord-256918-mauzesor	14	9	at	at	IN
cord-256918-mauzesor	14	10	the	the	DT
cord-256918-mauzesor	14	11	population	population	NN
cord-256918-mauzesor	14	12	level	level	NN
cord-256918-mauzesor	14	13	,	,	,
cord-256918-mauzesor	14	14	first	first	RB
cord-256918-mauzesor	14	15	proposed	propose	VBN
cord-256918-mauzesor	14	16	by	by	IN
cord-256918-mauzesor	14	17	Eigen	Eigen	NNP
cord-256918-mauzesor	14	18	,	,	,
cord-256918-mauzesor	14	19	Schuster	Schuster	NNP
cord-256918-mauzesor	14	20	and	and	CC
cord-256918-mauzesor	14	21	their	-PRON-	PRP$
cord-256918-mauzesor	14	22	colleagues	colleague	NNS
cord-256918-mauzesor	14	23	(	(	-LRB-
cord-256918-mauzesor	14	24	Eigen	Eigen	NNP
cord-256918-mauzesor	14	25	,	,	,
cord-256918-mauzesor	14	26	1971	1971	CD
cord-256918-mauzesor	14	27	;	;	:
cord-256918-mauzesor	14	28	Eigen	Eigen	NNP
cord-256918-mauzesor	14	29	and	and	CC
cord-256918-mauzesor	14	30	Schuster	Schuster	NNP
cord-256918-mauzesor	14	31	,	,	,
cord-256918-mauzesor	14	32	1979	1979	CD
cord-256918-mauzesor	14	33	)	)	-RRB-
cord-256918-mauzesor	14	34	.	.	.
cord-256918-mauzesor	15	1	It	-PRON-	PRP
cord-256918-mauzesor	15	2	means	mean	VBZ
cord-256918-mauzesor	15	3	that	that	IN
cord-256918-mauzesor	15	4	mutant	mutant	JJ
cord-256918-mauzesor	15	5	genomes	genome	NNS
cord-256918-mauzesor	15	6	are	be	VBP
cord-256918-mauzesor	15	7	generated	generate	VBN
cord-256918-mauzesor	15	8	at	at	IN
cord-256918-mauzesor	15	9	such	such	JJ
cord-256918-mauzesor	15	10	high	high	JJ
cord-256918-mauzesor	15	11	rates	rate	NNS
cord-256918-mauzesor	15	12	that	that	IN
cord-256918-mauzesor	15	13	each	each	DT
cord-256918-mauzesor	15	14	individual	individual	JJ
cord-256918-mauzesor	15	15	genomic	genomic	JJ
cord-256918-mauzesor	15	16	molecule	molecule	NN
cord-256918-mauzesor	15	17	differs	differ	VBZ
cord-256918-mauzesor	15	18	on	on	IN
cord-256918-mauzesor	15	19	average	average	NN
cord-256918-mauzesor	15	20	in	in	IN
cord-256918-mauzesor	15	21	one	one	CD
cord-256918-mauzesor	15	22	or	or	CC
cord-256918-mauzesor	15	23	a	a	DT
cord-256918-mauzesor	15	24	few	few	JJ
cord-256918-mauzesor	15	25	nucleotides	nucleotide	NNS
cord-256918-mauzesor	15	26	from	from	IN
cord-256918-mauzesor	15	27	the	the	DT
cord-256918-mauzesor	15	28	other	other	JJ
cord-256918-mauzesor	15	29	molecules	molecule	NNS
cord-256918-mauzesor	15	30	,	,	,
cord-256918-mauzesor	15	31	and	and	CC
cord-256918-mauzesor	15	32	each	each	DT
cord-256918-mauzesor	15	33	genomic	genomic	JJ
cord-256918-mauzesor	15	34	sequence	sequence	NN
cord-256918-mauzesor	15	35	may	may	MD
cord-256918-mauzesor	15	36	deviate	deviate	VB
cord-256918-mauzesor	15	37	from	from	IN
cord-256918-mauzesor	15	38	the	the	DT
cord-256918-mauzesor	15	39	average	average	JJ
cord-256918-mauzesor	15	40	or	or	CC
cord-256918-mauzesor	15	41	consensus	consensus	NN
cord-256918-mauzesor	15	42	sequence	sequence	NN
cord-256918-mauzesor	15	43	.	.	.
cord-256918-mauzesor	16	1	For	for	IN
cord-256918-mauzesor	16	2	example	example	NN
cord-256918-mauzesor	16	3	,	,	,
cord-256918-mauzesor	16	4	in	in	IN
cord-256918-mauzesor	16	5	the	the	DT
cord-256918-mauzesor	16	6	proposal	proposal	NN
cord-256918-mauzesor	16	7	of	of	IN
cord-256918-mauzesor	16	8	the	the	DT
cord-256918-mauzesor	16	9	quasispecies	quasispecies	NNP
cord-256918-mauzesor	16	10	model	model	NN
cord-256918-mauzesor	16	11	for	for	IN
cord-256918-mauzesor	16	12	phage	phage	NN
cord-256918-mauzesor	16	13	Qi	Qi	NNP
cord-256918-mauzesor	16	14	it	-PRON-	PRP
cord-256918-mauzesor	16	15	was	be	VBD
cord-256918-mauzesor	16	16	found	find	VBN
cord-256918-mauzesor	16	17	that	that	IN
cord-256918-mauzesor	16	18	the	the	DT
cord-256918-mauzesor	16	19	most	most	RBS
cord-256918-mauzesor	16	20	abundant	abundant	JJ
cord-256918-mauzesor	16	21	genome	genome	NN
cord-256918-mauzesor	16	22	amounted	amount	VBD
cord-256918-mauzesor	16	23	to	to	IN
cord-256918-mauzesor	16	24	10	10	CD
cord-256918-mauzesor	16	25	-20	-20	CD
cord-256918-mauzesor	16	26	%	%	NN
cord-256918-mauzesor	16	27	of	of	IN
cord-256918-mauzesor	16	28	the	the	DT
cord-256918-mauzesor	16	29	population	population	NN
cord-256918-mauzesor	16	30	.	.	.
cord-256918-mauzesor	17	1	This	this	DT
cord-256918-mauzesor	17	2	experimental	experimental	JJ
cord-256918-mauzesor	17	3	finding	finding	NN
cord-256918-mauzesor	17	4	agreed	agree	VBD
cord-256918-mauzesor	17	5	with	with	IN
cord-256918-mauzesor	17	6	theoretical	theoretical	JJ
cord-256918-mauzesor	17	7	predictions	prediction	NNS
cord-256918-mauzesor	17	8	of	of	IN
cord-256918-mauzesor	17	9	Eigen	Eigen	NNP
cord-256918-mauzesor	17	10	and	and	CC
cord-256918-mauzesor	17	11	colleagues	colleague	NNS
cord-256918-mauzesor	17	12	,	,	,
cord-256918-mauzesor	17	13	given	give	VBN
cord-256918-mauzesor	17	14	the	the	DT
cord-256918-mauzesor	17	15	complexity	complexity	NN
cord-256918-mauzesor	17	16	of	of	IN
cord-256918-mauzesor	17	17	the	the	DT
cord-256918-mauzesor	17	18	Qi	Qi	NNP
cord-256918-mauzesor	17	19	genome	genome	NN
cord-256918-mauzesor	17	20	and	and	CC
cord-256918-mauzesor	17	21	the	the	DT
cord-256918-mauzesor	17	22	mutation	mutation	NN
cord-256918-mauzesor	17	23	rate	rate	NN
cord-256918-mauzesor	17	24	during	during	IN
cord-256918-mauzesor	17	25	its	-PRON-	PRP$
cord-256918-mauzesor	17	26	replication	replication	NN
cord-256918-mauzesor	17	27	(	(	-LRB-
cord-256918-mauzesor	17	28	Domingo	Domingo	NNP
cord-256918-mauzesor	17	29	et	et	NNP
cord-256918-mauzesor	17	30	al	al	NNP
cord-256918-mauzesor	17	31	.	.	NNP
cord-256918-mauzesor	17	32	,	,	,
cord-256918-mauzesor	17	33	1978	1978	CD
cord-256918-mauzesor	17	34	)	)	-RRB-
cord-256918-mauzesor	17	35	.	.	.
cord-256918-mauzesor	18	1	Since	since	IN
cord-256918-mauzesor	18	2	this	this	DT
cord-256918-mauzesor	18	3	first	first	JJ
cord-256918-mauzesor	18	4	proposal	proposal	NN
cord-256918-mauzesor	18	5	that	that	DT
cord-256918-mauzesor	18	6	bacteriophage	bacteriophage	NN
cord-256918-mauzesor	18	7	Qi	Qi	NNP
cord-256918-mauzesor	18	8	,	,	,
cord-256918-mauzesor	18	9	replicating	replicate	VBG
cord-256918-mauzesor	18	10	in	in	IN
cord-256918-mauzesor	18	11	Escherichia	Escherichia	NNP
cord-256918-mauzesor	18	12	coli	coli	NNS
cord-256918-mauzesor	18	13	,	,	,
cord-256918-mauzesor	18	14	displayed	display	VBD
cord-256918-mauzesor	18	15	features	feature	NNS
cord-256918-mauzesor	18	16	of	of	IN
cord-256918-mauzesor	18	17	a	a	DT
cord-256918-mauzesor	18	18	quasispecies	quasispecie	NNS
cord-256918-mauzesor	18	19	,	,	,
cord-256918-mauzesor	18	20	a	a	DT
cord-256918-mauzesor	18	21	steadily	steadily	RB
cord-256918-mauzesor	18	22	increasing	increase	VBG
cord-256918-mauzesor	18	23	number	number	NN
cord-256918-mauzesor	18	24	of	of	IN
cord-256918-mauzesor	18	25	RNA	RNA	NNP
cord-256918-mauzesor	18	26	viruses	virus	NNS
cord-256918-mauzesor	18	27	have	have	VBP
cord-256918-mauzesor	18	28	been	be	VBN
cord-256918-mauzesor	18	29	shown	show	VBN
cord-256918-mauzesor	18	30	to	to	TO
cord-256918-mauzesor	18	31	share	share	VB
cord-256918-mauzesor	18	32	such	such	PDT
cord-256918-mauzesor	18	33	a	a	DT
cord-256918-mauzesor	18	34	population	population	NN
cord-256918-mauzesor	18	35	structure	structure	NN
cord-256918-mauzesor	18	36	(	(	-LRB-
cord-256918-mauzesor	18	37	Holland	Holland	NNP
cord-256918-mauzesor	18	38	et	et	NNP
cord-256918-mauzesor	18	39	al	al	NNP
cord-256918-mauzesor	18	40	.	.	NNP
cord-256918-mauzesor	18	41	,	,	,
cord-256918-mauzesor	18	42	1982	1982	CD
cord-256918-mauzesor	18	43	;	;	:
cord-256918-mauzesor	18	44	.	.	.
cord-256918-mauzesor	19	1	However	however	RB
cord-256918-mauzesor	19	2	,	,	,
cord-256918-mauzesor	19	3	there	there	EX
cord-256918-mauzesor	19	4	has	have	VBZ
cord-256918-mauzesor	19	5	been	be	VBN
cord-256918-mauzesor	19	6	a	a	DT
cord-256918-mauzesor	19	7	slow	slow	JJ
cord-256918-mauzesor	19	8	realisation	realisation	NN
cord-256918-mauzesor	19	9	of	of	IN
cord-256918-mauzesor	19	10	the	the	DT
cord-256918-mauzesor	19	11	biological	biological	JJ
cord-256918-mauzesor	19	12	implications	implication	NNS
cord-256918-mauzesor	19	13	of	of	IN
cord-256918-mauzesor	19	14	quasispecies	quasispecie	NNS
cord-256918-mauzesor	19	15	.	.	.
cord-256918-mauzesor	20	1	Since	since	IN
cord-256918-mauzesor	20	2	adaptability	adaptability	NN
cord-256918-mauzesor	20	3	of	of	IN
cord-256918-mauzesor	20	4	RNA	RNA	NNP
cord-256918-mauzesor	20	5	viruses	virus	NNS
cord-256918-mauzesor	20	6	is	be	VBZ
cord-256918-mauzesor	20	7	key	key	JJ
cord-256918-mauzesor	20	8	to	to	IN
cord-256918-mauzesor	20	9	viral	viral	JJ
cord-256918-mauzesor	20	10	pathogenesis	pathogenesis	NN
cord-256918-mauzesor	20	11	and	and	CC
cord-256918-mauzesor	20	12	strategies	strategy	NNS
cord-256918-mauzesor	20	13	for	for	IN
cord-256918-mauzesor	20	14	disease	disease	NN
cord-256918-mauzesor	20	15	control	control	NN
cord-256918-mauzesor	20	16	,	,	,
cord-256918-mauzesor	20	17	it	-PRON-	PRP
cord-256918-mauzesor	20	18	would	would	MD
cord-256918-mauzesor	20	19	seem	seem	VB
cord-256918-mauzesor	20	20	obvious	obvious	JJ
cord-256918-mauzesor	20	21	that	that	IN
cord-256918-mauzesor	20	22	quasispecies	quasispecie	NNS
cord-256918-mauzesor	20	23	should	should	MD
cord-256918-mauzesor	20	24	have	have	VB
cord-256918-mauzesor	20	25	been	be	VBN
cord-256918-mauzesor	20	26	regarded	regard	VBN
cord-256918-mauzesor	20	27	as	as	RB
cord-256918-mauzesor	20	28	highly	highly	RB
cord-256918-mauzesor	20	29	relevant	relevant	JJ
cord-256918-mauzesor	20	30	to	to	IN
cord-256918-mauzesor	20	31	these	these	DT
cord-256918-mauzesor	20	32	questions	question	NNS
cord-256918-mauzesor	20	33	(	(	-LRB-
cord-256918-mauzesor	20	34	Domingo	Domingo	NNP
cord-256918-mauzesor	20	35	,	,	,
cord-256918-mauzesor	20	36	1989	1989	CD
cord-256918-mauzesor	20	37	(	(	-LRB-
cord-256918-mauzesor	20	38	Domingo	Domingo	NNP
cord-256918-mauzesor	20	39	,	,	,
cord-256918-mauzesor	20	40	,	,	,
cord-256918-mauzesor	20	41	1996	1996	CD
cord-256918-mauzesor	20	42	Domingo	Domingo	NNP
cord-256918-mauzesor	20	43	and	and	CC
cord-256918-mauzesor	20	44	Holland	Holland	NNP
cord-256918-mauzesor	20	45	,	,	,
cord-256918-mauzesor	20	46	1992	1992	CD
cord-256918-mauzesor	20	47	;	;	.
cord-256918-mauzesor	21	1	Duarte	Duarte	NNP
cord-256918-mauzesor	21	2	et	et	NNP
cord-256918-mauzesor	21	3	al	al	NNP
cord-256918-mauzesor	21	4	.	.	.
cord-256918-mauzesor	22	1	,	,	,
cord-256918-mauzesor	22	2	1994	1994	CD
cord-256918-mauzesor	22	3	;	;	:
cord-256918-mauzesor	22	4	Novella	Novella	NNP
cord-256918-mauzesor	22	5	et	et	FW
cord-256918-mauzesor	22	6	al	al	NNP
cord-256918-mauzesor	22	7	.	.	NNP
cord-256918-mauzesor	22	8	,	,	,
cord-256918-mauzesor	22	9	1995	1995	CD
cord-256918-mauzesor	22	10	)	)	-RRB-
cord-256918-mauzesor	22	11	.	.	.
cord-256918-mauzesor	23	1	This	this	DT
cord-256918-mauzesor	23	2	paper	paper	NN
cord-256918-mauzesor	23	3	updates	update	VBZ
cord-256918-mauzesor	23	4	some	some	DT
cord-256918-mauzesor	23	5	observations	observation	NNS
cord-256918-mauzesor	23	6	on	on	IN
cord-256918-mauzesor	23	7	quasispecies	quasispecie	NNS
cord-256918-mauzesor	23	8	,	,	,
cord-256918-mauzesor	23	9	and	and	CC
cord-256918-mauzesor	23	10	highlights	highlight	VBZ
cord-256918-mauzesor	23	11	a	a	DT
cord-256918-mauzesor	23	12	few	few	JJ
cord-256918-mauzesor	23	13	critical	critical	JJ
cord-256918-mauzesor	23	14	issues	issue	NNS
cord-256918-mauzesor	23	15	.	.	.
cord-256918-mauzesor	24	1	The	the	DT
cord-256918-mauzesor	24	2	main	main	JJ
cord-256918-mauzesor	24	3	departure	departure	NN
cord-256918-mauzesor	24	4	of	of	IN
cord-256918-mauzesor	24	5	quasispecies	quasispecie	NNS
cord-256918-mauzesor	24	6	from	from	IN
cord-256918-mauzesor	24	7	previous	previous	JJ
cord-256918-mauzesor	24	8	models	model	NNS
cord-256918-mauzesor	24	9	of	of	IN
cord-256918-mauzesor	24	10	molecular	molecular	JJ
cord-256918-mauzesor	24	11	evolution	evolution	NN
cord-256918-mauzesor	24	12	is	be	VBZ
cord-256918-mauzesor	24	13	the	the	DT
cord-256918-mauzesor	24	14	consideration	consideration	NN
cord-256918-mauzesor	24	15	of	of	IN
cord-256918-mauzesor	24	16	the	the	DT
cord-256918-mauzesor	24	17	wild	wild	JJ
cord-256918-mauzesor	24	18	-	-	HYPH
cord-256918-mauzesor	24	19	type	type	NN
cord-256918-mauzesor	24	20	not	not	RB
cord-256918-mauzesor	24	21	as	as	IN
cord-256918-mauzesor	24	22	a	a	DT
cord-256918-mauzesor	24	23	genome	genome	NN
cord-256918-mauzesor	24	24	with	with	IN
cord-256918-mauzesor	24	25	a	a	DT
cord-256918-mauzesor	24	26	single	single	JJ
cord-256918-mauzesor	24	27	nucleotide	nucleotide	JJ
cord-256918-mauzesor	24	28	sequence	sequence	NN
cord-256918-mauzesor	24	29	,	,	,
cord-256918-mauzesor	24	30	but	but	CC
cord-256918-mauzesor	24	31	as	as	IN
cord-256918-mauzesor	24	32	a	a	DT
cord-256918-mauzesor	24	33	distribution	distribution	NN
cord-256918-mauzesor	24	34	of	of	IN
cord-256918-mauzesor	24	35	genomes	genome	NNS
cord-256918-mauzesor	24	36	which	which	WDT
cord-256918-mauzesor	24	37	act	act	VBP
cord-256918-mauzesor	24	38	as	as	IN
cord-256918-mauzesor	24	39	a	a	DT
cord-256918-mauzesor	24	40	unit	unit	NN
cord-256918-mauzesor	24	41	of	of	IN
cord-256918-mauzesor	24	42	selection	selection	NN
cord-256918-mauzesor	24	43	.	.	.
cord-256918-mauzesor	25	1	The	the	DT
cord-256918-mauzesor	25	2	absence	absence	NN
cord-256918-mauzesor	25	3	of	of	IN
cord-256918-mauzesor	25	4	a	a	DT
cord-256918-mauzesor	25	5	defined	define	VBN
cord-256918-mauzesor	25	6	wild	wild	JJ
cord-256918-mauzesor	25	7	-	-	HYPH
cord-256918-mauzesor	25	8	type	type	NN
cord-256918-mauzesor	25	9	has	have	VBZ
cord-256918-mauzesor	25	10	been	be	VBN
cord-256918-mauzesor	25	11	confirmed	confirm	VBN
cord-256918-mauzesor	25	12	experimentally	experimentally	RB
cord-256918-mauzesor	25	13	(	(	-LRB-
cord-256918-mauzesor	25	14	Domingo	Domingo	NNP
cord-256918-mauzesor	25	15	et	et	NNP
cord-256918-mauzesor	25	16	al	al	NNP
cord-256918-mauzesor	25	17	.	.	NNP
cord-256918-mauzesor	25	18	,	,	,
cord-256918-mauzesor	25	19	1978	1978	CD
cord-256918-mauzesor	25	20	.	.	.
cord-256918-mauzesor	26	1	A	a	DT
cord-256918-mauzesor	26	2	viral	viral	JJ
cord-256918-mauzesor	26	3	genome	genome	NN
cord-256918-mauzesor	26	4	is	be	VBZ
cord-256918-mauzesor	26	5	statistically	statistically	RB
cord-256918-mauzesor	26	6	defined	define	VBN
cord-256918-mauzesor	26	7	but	but	CC
cord-256918-mauzesor	26	8	individually	individually	RB
cord-256918-mauzesor	26	9	indeterminate	indeterminate	JJ
cord-256918-mauzesor	26	10	.	.	.
cord-256918-mauzesor	27	1	It	-PRON-	PRP
cord-256918-mauzesor	27	2	is	be	VBZ
cord-256918-mauzesor	27	3	not	not	RB
cord-256918-mauzesor	27	4	possible	possible	JJ
cord-256918-mauzesor	27	5	to	to	TO
cord-256918-mauzesor	27	6	attribute	attribute	VB
cord-256918-mauzesor	27	7	a	a	DT
cord-256918-mauzesor	27	8	biological	biological	JJ
cord-256918-mauzesor	27	9	behaviour	behaviour	NN
cord-256918-mauzesor	27	10	to	to	IN
cord-256918-mauzesor	27	11	a	a	DT
cord-256918-mauzesor	27	12	genomic	genomic	JJ
cord-256918-mauzesor	27	13	nucleotide	nucleotide	JJ
cord-256918-mauzesor	27	14	sequence	sequence	NN
cord-256918-mauzesor	27	15	with	with	IN
cord-256918-mauzesor	27	16	complete	complete	JJ
cord-256918-mauzesor	27	17	certainty	certainty	NN
cord-256918-mauzesor	27	18	.	.	.
cord-256918-mauzesor	28	1	We	-PRON-	PRP
cord-256918-mauzesor	28	2	must	must	MD
cord-256918-mauzesor	28	3	,	,	,
cord-256918-mauzesor	28	4	therefore	therefore	RB
cord-256918-mauzesor	28	5	,	,	,
cord-256918-mauzesor	28	6	rely	rely	VB
cord-256918-mauzesor	28	7	on	on	IN
cord-256918-mauzesor	28	8	the	the	DT
cord-256918-mauzesor	28	9	statistical	statistical	JJ
cord-256918-mauzesor	28	10	accumulation	accumulation	NN
cord-256918-mauzesor	28	11	of	of	IN
cord-256918-mauzesor	28	12	data	datum	NNS
cord-256918-mauzesor	28	13	.	.	.
cord-256918-mauzesor	29	1	In	in	IN
cord-256918-mauzesor	29	2	a	a	DT
cord-256918-mauzesor	29	3	study	study	NN
cord-256918-mauzesor	29	4	of	of	IN
cord-256918-mauzesor	29	5	antigenic	antigenic	JJ
cord-256918-mauzesor	29	6	sites	site	NNS
cord-256918-mauzesor	29	7	of	of	IN
cord-256918-mauzesor	29	8	foot	foot	NN
cord-256918-mauzesor	29	9	-	-	HYPH
cord-256918-mauzesor	29	10	and	and	CC
cord-256918-mauzesor	29	11	-	-	HYPH
cord-256918-mauzesor	29	12	mouth	mouth	NN
cord-256918-mauzesor	29	13	disease	disease	NN
cord-256918-mauzesor	29	14	virus	virus	NN
cord-256918-mauzesor	29	15	(	(	-LRB-
cord-256918-mauzesor	29	16	FMDV	FMDV	NNP
cord-256918-mauzesor	29	17	)	)	-RRB-
cord-256918-mauzesor	29	18	(	(	-LRB-
cord-256918-mauzesor	29	19	the	the	DT
cord-256918-mauzesor	29	20	example	example	NN
cord-256918-mauzesor	29	21	applies	apply	VBZ
cord-256918-mauzesor	29	22	to	to	IN
cord-256918-mauzesor	29	23	any	any	DT
cord-256918-mauzesor	29	24	other	other	JJ
cord-256918-mauzesor	29	25	virus	virus	NN
cord-256918-mauzesor	29	26	)	)	-RRB-
cord-256918-mauzesor	29	27	the	the	DT
cord-256918-mauzesor	29	28	assignment	assignment	NN
cord-256918-mauzesor	29	29	of	of	IN
cord-256918-mauzesor	29	30	a	a	DT
cord-256918-mauzesor	29	31	neutralising	neutralise	VBG
cord-256918-mauzesor	29	32	monoclonal	monoclonal	JJ
cord-256918-mauzesor	29	33	antibody	antibody	NN
cord-256918-mauzesor	29	34	to	to	IN
cord-256918-mauzesor	29	35	a	a	DT
cord-256918-mauzesor	29	36	given	give	VBN
cord-256918-mauzesor	29	37	epitope	epitope	NN
cord-256918-mauzesor	29	38	necessitates	necessitate	VBZ
cord-256918-mauzesor	29	39	that	that	IN
cord-256918-mauzesor	29	40	different	different	JJ
cord-256918-mauzesor	29	41	clonal	clonal	JJ
cord-256918-mauzesor	29	42	preparations	preparation	NNS
cord-256918-mauzesor	29	43	of	of	IN
cord-256918-mauzesor	29	44	FMDV	FMDV	NNP
cord-256918-mauzesor	29	45	repeatedly	repeatedly	RB
cord-256918-mauzesor	29	46	produce	produce	VBP
cord-256918-mauzesor	29	47	escape	escape	NN
cord-256918-mauzesor	29	48	mutants	mutant	NNS
cord-256918-mauzesor	29	49	with	with	IN
cord-256918-mauzesor	29	50	amino	amino	NN
cord-256918-mauzesor	29	51	acid	acid	NN
cord-256918-mauzesor	29	52	substitutions	substitution	NNS
cord-256918-mauzesor	29	53	at	at	IN
cord-256918-mauzesor	29	54	the	the	DT
cord-256918-mauzesor	29	55	same	same	JJ
cord-256918-mauzesor	29	56	epitope	epitope	NN
cord-256918-mauzesor	29	57	region	region	NN
cord-256918-mauzesor	29	58	.	.	.
cord-256918-mauzesor	30	1	Since	since	IN
cord-256918-mauzesor	30	2	it	-PRON-	PRP
cord-256918-mauzesor	30	3	is	be	VBZ
cord-256918-mauzesor	30	4	not	not	RB
cord-256918-mauzesor	30	5	possible	possible	JJ
cord-256918-mauzesor	30	6	at	at	IN
cord-256918-mauzesor	30	7	present	present	NN
cord-256918-mauzesor	30	8	to	to	TO
cord-256918-mauzesor	30	9	sequence	sequence	VB
cord-256918-mauzesor	30	10	an	an	DT
cord-256918-mauzesor	30	11	individual	individual	JJ
cord-256918-mauzesor	30	12	genomic	genomic	JJ
cord-256918-mauzesor	30	13	molecule	molecule	NN
cord-256918-mauzesor	30	14	,	,	,
cord-256918-mauzesor	30	15	a	a	DT
cord-256918-mauzesor	30	16	large	large	JJ
cord-256918-mauzesor	30	17	number	number	NN
cord-256918-mauzesor	30	18	of	of	IN
cord-256918-mauzesor	30	19	genomes	genome	NNS
cord-256918-mauzesor	30	20	(	(	-LRB-
cord-256918-mauzesor	30	21	10	10	CD
cord-256918-mauzesor	30	22	8	8	CD
cord-256918-mauzesor	30	23	-10	-10	CD
cord-256918-mauzesor	30	24	11	11	CD
cord-256918-mauzesor	30	25	)	)	-RRB-
cord-256918-mauzesor	30	26	must	must	MD
cord-256918-mauzesor	30	27	be	be	VB
cord-256918-mauzesor	30	28	gathered	gather	VBN
cord-256918-mauzesor	30	29	,	,	,
cord-256918-mauzesor	30	30	following	follow	VBG
cord-256918-mauzesor	30	31	either	either	CC
cord-256918-mauzesor	30	32	biological	biological	JJ
cord-256918-mauzesor	30	33	or	or	CC
cord-256918-mauzesor	30	34	molecular	molecular	JJ
cord-256918-mauzesor	30	35	cloning	cloning	NN
cord-256918-mauzesor	30	36	,	,	,
cord-256918-mauzesor	30	37	before	before	IN
cord-256918-mauzesor	30	38	applying	apply	VBG
cord-256918-mauzesor	30	39	the	the	DT
cord-256918-mauzesor	30	40	chemistry	chemistry	NN
cord-256918-mauzesor	30	41	for	for	IN
cord-256918-mauzesor	30	42	sequence	sequence	NN
cord-256918-mauzesor	30	43	determination	determination	NN
cord-256918-mauzesor	30	44	.	.	.
cord-256918-mauzesor	31	1	Biological	biological	JJ
cord-256918-mauzesor	31	2	cloning	cloning	NN
cord-256918-mauzesor	31	3	may	may	MD
cord-256918-mauzesor	31	4	imply	imply	VB
cord-256918-mauzesor	31	5	some	some	DT
cord-256918-mauzesor	31	6	selection	selection	NN
cord-256918-mauzesor	31	7	bias	bias	NN
cord-256918-mauzesor	31	8	on	on	IN
cord-256918-mauzesor	31	9	viruses	virus	NNS
cord-256918-mauzesor	31	10	.	.	.
cord-256918-mauzesor	32	1	This	this	DT
cord-256918-mauzesor	32	2	led	lead	VBD
cord-256918-mauzesor	32	3	to	to	IN
cord-256918-mauzesor	32	4	the	the	DT
cord-256918-mauzesor	32	5	timely	timely	JJ
cord-256918-mauzesor	32	6	statement	statement	NN
cord-256918-mauzesor	32	7	concerning	concern	VBG
cord-256918-mauzesor	32	8	human	human	JJ
cord-256918-mauzesor	32	9	immunodeficiency	immunodeficiency	NN
cord-256918-mauzesor	32	10	virus	virus	NN
cord-256918-mauzesor	32	11	(	(	-LRB-
cord-256918-mauzesor	32	12	HIV)-1	HIV)-1	NNP
cord-256918-mauzesor	32	13	quasispecies	quasispecies	NNP
cord-256918-mauzesor	32	14	analysis	analysis	NN
cord-256918-mauzesor	32	15	'	'	''
cord-256918-mauzesor	32	16	'	'	''
cord-256918-mauzesor	32	17	to	to	IN
cord-256918-mauzesor	32	18	culture	culture	NN
cord-256918-mauzesor	32	19	is	be	VBZ
cord-256918-mauzesor	32	20	to	to	TO
cord-256918-mauzesor	32	21	disturb	disturb	VB
cord-256918-mauzesor	32	22	'	'	''
cord-256918-mauzesor	32	23	'	'	''
cord-256918-mauzesor	33	1	(	(	-LRB-
cord-256918-mauzesor	33	2	Meyerhans	Meyerhans	NNPS
cord-256918-mauzesor	33	3	et	et	NNP
cord-256918-mauzesor	33	4	al	al	NNP
cord-256918-mauzesor	33	5	.	.	NNP
cord-256918-mauzesor	33	6	,	,	,
cord-256918-mauzesor	33	7	1989	1989	CD
cord-256918-mauzesor	33	8	)	)	-RRB-
cord-256918-mauzesor	33	9	.	.	.
cord-256918-mauzesor	34	1	Other	other	JJ
cord-256918-mauzesor	34	2	variations	variation	NNS
cord-256918-mauzesor	34	3	may	may	MD
cord-256918-mauzesor	34	4	be	be	VB
cord-256918-mauzesor	34	5	found	find	VBN
cord-256918-mauzesor	34	6	in	in	IN
cord-256918-mauzesor	34	7	the	the	DT
cord-256918-mauzesor	34	8	mutant	mutant	JJ
cord-256918-mauzesor	34	9	spectra	spectra	NN
cord-256918-mauzesor	34	10	derived	derive	VBN
cord-256918-mauzesor	34	11	from	from	IN
cord-256918-mauzesor	34	12	reverse	reverse	JJ
cord-256918-mauzesor	34	13	transcription	transcription	NN
cord-256918-mauzesor	34	14	(	(	-LRB-
cord-256918-mauzesor	34	15	RT	RT	NNP
cord-256918-mauzesor	34	16	)	)	-RRB-
cord-256918-mauzesor	34	17	polymerase	polymerase	NN
cord-256918-mauzesor	34	18	chain	chain	NN
cord-256918-mauzesor	34	19	reaction	reaction	NN
cord-256918-mauzesor	34	20	(	(	-LRB-
cord-256918-mauzesor	34	21	PCR	PCR	NNP
cord-256918-mauzesor	34	22	)	)	-RRB-
cord-256918-mauzesor	34	23	amplification	amplification	NN
cord-256918-mauzesor	34	24	procedures	procedure	NNS
cord-256918-mauzesor	34	25	,	,	,
cord-256918-mauzesor	34	26	or	or	CC
cord-256918-mauzesor	34	27	sequence	sequence	NN
cord-256918-mauzesor	34	28	determination	determination	NN
cord-256918-mauzesor	34	29	from	from	IN
cord-256918-mauzesor	34	30	molecular	molecular	JJ
cord-256918-mauzesor	34	31	clones	clone	NNS
cord-256918-mauzesor	34	32	obtained	obtain	VBN
cord-256918-mauzesor	34	33	in	in	IN
cord-256918-mauzesor	34	34	E.	E.	NNP
cord-256918-mauzesor	34	35	coli	coli	NNS
cord-256918-mauzesor	34	36	or	or	CC
cord-256918-mauzesor	34	37	other	other	JJ
cord-256918-mauzesor	34	38	cell	cell	NN
cord-256918-mauzesor	34	39	-	-	HYPH
cord-256918-mauzesor	34	40	vector	vector	NN
cord-256918-mauzesor	34	41	systems	system	NNS
cord-256918-mauzesor	34	42	.	.	.
cord-256918-mauzesor	35	1	Variations	variation	NNS
cord-256918-mauzesor	35	2	and	and	CC
cord-256918-mauzesor	35	3	biases	bias	NNS
cord-256918-mauzesor	35	4	may	may	MD
cord-256918-mauzesor	35	5	arise	arise	VB
cord-256918-mauzesor	35	6	from	from	IN
cord-256918-mauzesor	35	7	the	the	DT
cord-256918-mauzesor	35	8	selective	selective	JJ
cord-256918-mauzesor	35	9	cloning	cloning	NN
cord-256918-mauzesor	35	10	of	of	IN
cord-256918-mauzesor	35	11	subsets	subset	NNS
cord-256918-mauzesor	35	12	of	of	IN
cord-256918-mauzesor	35	13	genomes	genome	NNS
cord-256918-mauzesor	35	14	,	,	,
cord-256918-mauzesor	35	15	or	or	CC
cord-256918-mauzesor	35	16	other	other	JJ
cord-256918-mauzesor	35	17	mechanisms	mechanism	NNS
cord-256918-mauzesor	35	18	(	(	-LRB-
cord-256918-mauzesor	35	19	Szybalski	Szybalski	NNP
cord-256918-mauzesor	35	20	,	,	,
cord-256918-mauzesor	35	21	1993	1993	CD
cord-256918-mauzesor	35	22	;	;	:
cord-256918-mauzesor	36	1	Forns	Forns	NNP
cord-256918-mauzesor	36	2	et	et	NNP
cord-256918-mauzesor	36	3	al	al	NNP
cord-256918-mauzesor	36	4	.	.	NNP
cord-256918-mauzesor	36	5	,	,	,
cord-256918-mauzesor	36	6	1997	1997	CD
cord-256918-mauzesor	36	7	)	)	-RRB-
cord-256918-mauzesor	36	8	and	and	CC
cord-256918-mauzesor	36	9	cloning	clone	VBG
cord-256918-mauzesor	36	10	in	in	IN
cord-256918-mauzesor	36	11	alternative	alternative	JJ
cord-256918-mauzesor	36	12	vector	vector	NN
cord-256918-mauzesor	36	13	-	-	HYPH
cord-256918-mauzesor	36	14	cell	cell	NN
cord-256918-mauzesor	36	15	systems	system	NNS
cord-256918-mauzesor	36	16	may	may	MD
cord-256918-mauzesor	36	17	be	be	VB
cord-256918-mauzesor	36	18	required	require	VBN
cord-256918-mauzesor	36	19	.	.	.
cord-256918-mauzesor	37	1	RT	RT	NNP
cord-256918-mauzesor	37	2	-	-	HYPH
cord-256918-mauzesor	37	3	PCR	PCR	NNP
cord-256918-mauzesor	37	4	errors	error	NNS
cord-256918-mauzesor	37	5	in	in	IN
cord-256918-mauzesor	37	6	amplified	amplify	VBN
cord-256918-mauzesor	37	7	genomes	genome	NNS
cord-256918-mauzesor	37	8	must	must	MD
cord-256918-mauzesor	37	9	be	be	VB
cord-256918-mauzesor	37	10	controlled	control	VBN
cord-256918-mauzesor	37	11	by	by	IN
cord-256918-mauzesor	37	12	using	use	VBG
cord-256918-mauzesor	37	13	the	the	DT
cord-256918-mauzesor	37	14	same	same	JJ
cord-256918-mauzesor	37	15	protocols	protocol	NNS
cord-256918-mauzesor	37	16	for	for	IN
cord-256918-mauzesor	37	17	experimental	experimental	JJ
cord-256918-mauzesor	37	18	and	and	CC
cord-256918-mauzesor	37	19	problem	problem	NN
cord-256918-mauzesor	37	20	samples	sample	NNS
cord-256918-mauzesor	37	21	(	(	-LRB-
cord-256918-mauzesor	37	22	Nájera	Nájera	NNP
cord-256918-mauzesor	37	23	et	et	FW
cord-256918-mauzesor	37	24	al	al	NNP
cord-256918-mauzesor	37	25	.	.	NNP
cord-256918-mauzesor	37	26	,	,	,
cord-256918-mauzesor	37	27	1995	1995	CD
cord-256918-mauzesor	37	28	)	)	-RRB-
cord-256918-mauzesor	37	29	.	.	.
cord-256918-mauzesor	38	1	It	-PRON-	PRP
cord-256918-mauzesor	38	2	is	be	VBZ
cord-256918-mauzesor	38	3	not	not	RB
cord-256918-mauzesor	38	4	surprising	surprising	JJ
cord-256918-mauzesor	38	5	,	,	,
cord-256918-mauzesor	38	6	therefore	therefore	RB
cord-256918-mauzesor	38	7	,	,	,
cord-256918-mauzesor	38	8	that	that	IN
cord-256918-mauzesor	38	9	the	the	DT
cord-256918-mauzesor	38	10	level	level	NN
cord-256918-mauzesor	38	11	of	of	IN
cord-256918-mauzesor	38	12	genetic	genetic	JJ
cord-256918-mauzesor	38	13	heterogeneity	heterogeneity	NN
cord-256918-mauzesor	38	14	of	of	IN
cord-256918-mauzesor	38	15	viruses	virus	NNS
cord-256918-mauzesor	38	16	cultured	culture	VBN
cord-256918-mauzesor	38	17	in	in	IN
cord-256918-mauzesor	38	18	cells	cell	NNS
cord-256918-mauzesor	38	19	is	be	VBZ
cord-256918-mauzesor	38	20	not	not	RB
cord-256918-mauzesor	38	21	significantly	significantly	RB
cord-256918-mauzesor	38	22	different	different	JJ
cord-256918-mauzesor	38	23	from	from	IN
cord-256918-mauzesor	38	24	those	those	DT
cord-256918-mauzesor	38	25	estimated	estimate	VBN
cord-256918-mauzesor	38	26	using	use	VBG
cord-256918-mauzesor	38	27	biological	biological	JJ
cord-256918-mauzesor	38	28	molecular	molecular	JJ
cord-256918-mauzesor	38	29	cloning	cloning	NN
cord-256918-mauzesor	38	30	or	or	CC
cord-256918-mauzesor	38	31	from	from	IN
cord-256918-mauzesor	38	32	RT	RT	NNP
cord-256918-mauzesor	38	33	-	-	HYPH
cord-256918-mauzesor	38	34	PCR	PCR	NNP
cord-256918-mauzesor	38	35	.	.	.
cord-256918-mauzesor	39	1	Molecular	molecular	JJ
cord-256918-mauzesor	39	2	error	error	NN
cord-256918-mauzesor	39	3	-	-	HYPH
cord-256918-mauzesor	39	4	prone	prone	JJ
cord-256918-mauzesor	39	5	replication	replication	NN
cord-256918-mauzesor	39	6	is	be	VBZ
cord-256918-mauzesor	39	7	based	base	VBN
cord-256918-mauzesor	39	8	on	on	IN
cord-256918-mauzesor	39	9	the	the	DT
cord-256918-mauzesor	39	10	absence	absence	NN
cord-256918-mauzesor	39	11	of	of	IN
cord-256918-mauzesor	39	12	proofreading	proofreading	NN
cord-256918-mauzesor	39	13	-	-	HYPH
cord-256918-mauzesor	39	14	repair	repair	NN
cord-256918-mauzesor	39	15	,	,	,
cord-256918-mauzesor	39	16	3	3	CD
cord-256918-mauzesor	39	17	%	%	NN
cord-256918-mauzesor	39	18	-5	-5	CD
cord-256918-mauzesor	39	19	%	%	NN
cord-256918-mauzesor	39	20	exonuclease	exonuclease	NN
cord-256918-mauzesor	39	21	activity	activity	NN
cord-256918-mauzesor	39	22	Sousa	Sousa	NNP
cord-256918-mauzesor	39	23	,	,	,
cord-256918-mauzesor	39	24	1996	1996	CD
cord-256918-mauzesor	39	25	)	)	-RRB-
cord-256918-mauzesor	39	26	.	.	.
cord-256918-mauzesor	40	1	This	this	DT
cord-256918-mauzesor	40	2	applies	apply	VBZ
cord-256918-mauzesor	40	3	to	to	IN
cord-256918-mauzesor	40	4	the	the	DT
cord-256918-mauzesor	40	5	enzymes	enzyme	NNS
cord-256918-mauzesor	40	6	that	that	WDT
cord-256918-mauzesor	40	7	replicate	replicate	VBP
cord-256918-mauzesor	40	8	or	or	CC
cord-256918-mauzesor	40	9	retrotranscribe	retrotranscribe	VBP
cord-256918-mauzesor	40	10	viral	viral	JJ
cord-256918-mauzesor	40	11	genomes	genome	NNS
cord-256918-mauzesor	40	12	as	as	RB
cord-256918-mauzesor	40	13	well	well	RB
cord-256918-mauzesor	40	14	as	as	IN
cord-256918-mauzesor	40	15	to	to	IN
cord-256918-mauzesor	40	16	those	those	DT
cord-256918-mauzesor	40	17	that	that	WDT
cord-256918-mauzesor	40	18	amplify	amplify	VBP
cord-256918-mauzesor	40	19	their	-PRON-	PRP$
cord-256918-mauzesor	40	20	genomes	genome	NNS
cord-256918-mauzesor	40	21	in	in	IN
cord-256918-mauzesor	40	22	vitro	vitro	FW
cord-256918-mauzesor	40	23	often	often	RB
cord-256918-mauzesor	40	24	with	with	IN
cord-256918-mauzesor	40	25	comparable	comparable	JJ
cord-256918-mauzesor	40	26	numbers	number	NNS
cord-256918-mauzesor	40	27	of	of	IN
cord-256918-mauzesor	40	28	replication	replication	NN
cord-256918-mauzesor	40	29	rounds	round	NNS
cord-256918-mauzesor	40	30	.	.	.
cord-256918-mauzesor	41	1	Heterogeneities	heterogeneity	NNS
cord-256918-mauzesor	41	2	are	be	VBP
cord-256918-mauzesor	41	3	observed	observe	VBN
cord-256918-mauzesor	41	4	when	when	WRB
cord-256918-mauzesor	41	5	visualising	visualise	VBG
cord-256918-mauzesor	41	6	a	a	DT
cord-256918-mauzesor	41	7	consensus	consensus	NN
cord-256918-mauzesor	41	8	sequence	sequence	NN
cord-256918-mauzesor	41	9	,	,	,
cord-256918-mauzesor	41	10	i.e.	i.e.	FW
cord-256918-mauzesor	41	11	double	double	JJ
cord-256918-mauzesor	41	12	bands	band	NNS
cord-256918-mauzesor	41	13	or	or	CC
cord-256918-mauzesor	41	14	similar	similar	JJ
cord-256918-mauzesor	41	15	.	.	.
cord-256918-mauzesor	42	1	In	in	IN
cord-256918-mauzesor	42	2	these	these	DT
cord-256918-mauzesor	42	3	cases	case	NNS
cord-256918-mauzesor	42	4	,	,	,
cord-256918-mauzesor	42	5	populations	population	NNS
cord-256918-mauzesor	42	6	almost	almost	RB
cord-256918-mauzesor	42	7	systematically	systematically	RB
cord-256918-mauzesor	42	8	segregate	segregate	VBP
cord-256918-mauzesor	42	9	into	into	IN
cord-256918-mauzesor	42	10	the	the	DT
cord-256918-mauzesor	42	11	expected	expect	VBN
cord-256918-mauzesor	42	12	distinct	distinct	JJ
cord-256918-mauzesor	42	13	genomes	genome	NNS
cord-256918-mauzesor	42	14	when	when	WRB
cord-256918-mauzesor	42	15	biological	biological	JJ
cord-256918-mauzesor	42	16	or	or	CC
cord-256918-mauzesor	42	17	molecular	molecular	JJ
cord-256918-mauzesor	42	18	cloning	cloning	NN
cord-256918-mauzesor	42	19	is	be	VBZ
cord-256918-mauzesor	42	20	undertaken	undertake	VBN
cord-256918-mauzesor	42	21	.	.	.
cord-256918-mauzesor	43	1	This	this	DT
cord-256918-mauzesor	43	2	finding	finding	NN
cord-256918-mauzesor	43	3	may	may	MD
cord-256918-mauzesor	43	4	be	be	VB
cord-256918-mauzesor	43	5	statistically	statistically	RB
cord-256918-mauzesor	43	6	predicted	predict	VBN
cord-256918-mauzesor	43	7	as	as	IN
cord-256918-mauzesor	43	8	only	only	RB
cord-256918-mauzesor	43	9	a	a	DT
cord-256918-mauzesor	43	10	minority	minority	NN
cord-256918-mauzesor	43	11	of	of	IN
cord-256918-mauzesor	43	12	mutations	mutation	NNS
cord-256918-mauzesor	43	13	or	or	CC
cord-256918-mauzesor	43	14	heterogeneous	heterogeneous	JJ
cord-256918-mauzesor	43	15	positions	position	NNS
cord-256918-mauzesor	43	16	encountered	encounter	VBN
cord-256918-mauzesor	43	17	in	in	IN
cord-256918-mauzesor	43	18	handling	handle	VBG
cord-256918-mauzesor	43	19	viral	viral	JJ
cord-256918-mauzesor	43	20	genomes	genome	NNS
cord-256918-mauzesor	43	21	will	will	MD
cord-256918-mauzesor	43	22	Additional	additional	JJ
cord-256918-mauzesor	43	23	examples	example	NNS
cord-256918-mauzesor	43	24	can	can	MD
cord-256918-mauzesor	43	25	be	be	VB
cord-256918-mauzesor	43	26	found	find	VBN
cord-256918-mauzesor	43	27	in	in	IN
cord-256918-mauzesor	43	28	Domingo	Domingo	NNP
cord-256918-mauzesor	43	29	(	(	-LRB-
cord-256918-mauzesor	43	30	1996	1996	CD
cord-256918-mauzesor	43	31	)	)	-RRB-
cord-256918-mauzesor	43	32	and	and	CC
cord-256918-mauzesor	43	33	actually	actually	RB
cord-256918-mauzesor	43	34	have	have	VB
cord-256918-mauzesor	43	35	an	an	DT
cord-256918-mauzesor	43	36	effect	effect	NN
cord-256918-mauzesor	43	37	on	on	IN
cord-256918-mauzesor	43	38	the	the	DT
cord-256918-mauzesor	43	39	result	result	NN
cord-256918-mauzesor	43	40	of	of	IN
cord-256918-mauzesor	43	41	the	the	DT
cord-256918-mauzesor	43	42	biological	biological	JJ
cord-256918-mauzesor	43	43	or	or	CC
cord-256918-mauzesor	43	44	cloning	clone	VBG
cord-256918-mauzesor	43	45	assays	assay	NNS
cord-256918-mauzesor	43	46	.	.	.
cord-256918-mauzesor	44	1	The	the	DT
cord-256918-mauzesor	44	2	primary	primary	JJ
cord-256918-mauzesor	44	3	conclusion	conclusion	NN
cord-256918-mauzesor	44	4	from	from	IN
cord-256918-mauzesor	44	5	published	publish	VBN
cord-256918-mauzesor	44	6	data	data	NN
cord-256918-mauzesor	44	7	is	be	VBZ
cord-256918-mauzesor	44	8	that	that	IN
cord-256918-mauzesor	44	9	RNA	RNA	NNP
cord-256918-mauzesor	44	10	viruses	virus	NNS
cord-256918-mauzesor	44	11	(	(	-LRB-
cord-256918-mauzesor	44	12	including	include	VBG
cord-256918-mauzesor	44	13	viruses	virus	NNS
cord-256918-mauzesor	44	14	which	which	WDT
cord-256918-mauzesor	44	15	use	use	VBP
cord-256918-mauzesor	44	16	RNA	RNA	NNP
cord-256918-mauzesor	44	17	as	as	IN
cord-256918-mauzesor	44	18	replicative	replicative	JJ
cord-256918-mauzesor	44	19	intermediate	intermediate	NN
cord-256918-mauzesor	44	20	such	such	JJ
cord-256918-mauzesor	44	21	as	as	IN
cord-256918-mauzesor	44	22	hepatitis	hepatitis	NN
cord-256918-mauzesor	44	23	B	B	NNP
cord-256918-mauzesor	44	24	virus	virus	NN
cord-256918-mauzesor	44	25	)	)	-RRB-
cord-256918-mauzesor	44	26	behave	behave	VBP
cord-256918-mauzesor	44	27	largely	largely	RB
cord-256918-mauzesor	44	28	as	as	IN
cord-256918-mauzesor	44	29	predicted	predict	VBN
cord-256918-mauzesor	44	30	by	by	IN
cord-256918-mauzesor	44	31	the	the	DT
cord-256918-mauzesor	44	32	quasispecies	quasispecies	NNP
cord-256918-mauzesor	44	33	model	model	NN
cord-256918-mauzesor	44	34	of	of	IN
cord-256918-mauzesor	44	35	molecular	molecular	JJ
cord-256918-mauzesor	44	36	evolution	evolution	NN
cord-256918-mauzesor	44	37	.	.	.
cord-256918-mauzesor	45	1	Quasispecies	quasispecie	NNS
cord-256918-mauzesor	45	2	swarms	swarm	NNS
cord-256918-mauzesor	45	3	,	,	,
cord-256918-mauzesor	45	4	and	and	CC
cord-256918-mauzesor	45	5	not	not	RB
cord-256918-mauzesor	45	6	any	any	DT
cord-256918-mauzesor	45	7	sort	sort	NN
cord-256918-mauzesor	45	8	of	of	RB
cord-256918-mauzesor	45	9	defined	define	VBN
cord-256918-mauzesor	45	10	genetic	genetic	JJ
cord-256918-mauzesor	45	11	entity	entity	NN
cord-256918-mauzesor	45	12	,	,	,
cord-256918-mauzesor	45	13	are	be	VBP
cord-256918-mauzesor	45	14	those	those	DT
cord-256918-mauzesor	45	15	that	that	WDT
cord-256918-mauzesor	45	16	replicate	replicate	VBP
cord-256918-mauzesor	45	17	in	in	IN
cord-256918-mauzesor	45	18	infected	infected	JJ
cord-256918-mauzesor	45	19	hosts	host	NNS
cord-256918-mauzesor	45	20	as	as	IN
cord-256918-mauzesor	45	21	they	-PRON-	PRP
cord-256918-mauzesor	45	22	produce	produce	VBP
cord-256918-mauzesor	45	23	disease	disease	NN
cord-256918-mauzesor	45	24	Domingo	Domingo	NNP
cord-256918-mauzesor	45	25	et	et	NNP
cord-256918-mauzesor	45	26	al	al	NNP
cord-256918-mauzesor	45	27	.	.	NNP
cord-256918-mauzesor	45	28	,	,	,
cord-256918-mauzesor	45	29	1995	1995	CD
cord-256918-mauzesor	45	30	;	;	:
cord-256918-mauzesor	45	31	Marcus	Marcus	NNP
cord-256918-mauzesor	45	32	et	et	NNP
cord-256918-mauzesor	45	33	al	al	NNP
cord-256918-mauzesor	45	34	.	.	NNP
cord-256918-mauzesor	45	35	,	,	,
cord-256918-mauzesor	45	36	1998	1998	CD
cord-256918-mauzesor	45	37	)	)	-RRB-
cord-256918-mauzesor	45	38	.	.	.
cord-256918-mauzesor	46	1	Virologists	virologist	NNS
cord-256918-mauzesor	46	2	use	use	VBP
cord-256918-mauzesor	46	3	an	an	DT
cord-256918-mauzesor	46	4	extended	extended	JJ
cord-256918-mauzesor	46	5	definition	definition	NN
cord-256918-mauzesor	46	6	of	of	IN
cord-256918-mauzesor	46	7	quasispecies	quasispecie	NNS
cord-256918-mauzesor	46	8	so	so	IN
cord-256918-mauzesor	46	9	that	that	IN
cord-256918-mauzesor	46	10	recombination	recombination	NN
cord-256918-mauzesor	46	11	can	can	MD
cord-256918-mauzesor	46	12	also	also	RB
cord-256918-mauzesor	46	13	contribute	contribute	VB
cord-256918-mauzesor	46	14	to	to	IN
cord-256918-mauzesor	46	15	the	the	DT
cord-256918-mauzesor	46	16	mutant	mutant	JJ
cord-256918-mauzesor	46	17	spectrum	spectrum	NN
cord-256918-mauzesor	46	18	.	.	.
cord-256918-mauzesor	47	1	Rowe	Rowe	NNP
cord-256918-mauzesor	47	2	et	et	NNP
cord-256918-mauzesor	47	3	al	al	NNP
cord-256918-mauzesor	47	4	.	.	.
cord-256918-mauzesor	48	1	(	(	-LRB-
cord-256918-mauzesor	48	2	1997	1997	CD
cord-256918-mauzesor	48	3	)	)	-RRB-
cord-256918-mauzesor	48	4	showed	show	VBD
cord-256918-mauzesor	48	5	that	that	IN
cord-256918-mauzesor	48	6	the	the	DT
cord-256918-mauzesor	48	7	complexity	complexity	NN
cord-256918-mauzesor	48	8	of	of	IN
cord-256918-mauzesor	48	9	the	the	DT
cord-256918-mauzesor	48	10	coronavirus	coronavirus	NN
cord-256918-mauzesor	48	11	murine	murine	JJ
cord-256918-mauzesor	48	12	hepatitis	hepatitis	NN
cord-256918-mauzesor	48	13	virus	virus	NN
cord-256918-mauzesor	48	14	quasispecies	quasispecies	NNP
cord-256918-mauzesor	48	15	,	,	,
cord-256918-mauzesor	48	16	defined	define	VBN
cord-256918-mauzesor	48	17	by	by	IN
cord-256918-mauzesor	48	18	the	the	DT
cord-256918-mauzesor	48	19	presence	presence	NN
cord-256918-mauzesor	48	20	of	of	IN
cord-256918-mauzesor	48	21	recombinant	recombinant	JJ
cord-256918-mauzesor	48	22	genomes	genome	NNS
cord-256918-mauzesor	48	23	and	and	CC
cord-256918-mauzesor	48	24	point	point	NN
cord-256918-mauzesor	48	25	mutations	mutation	NNS
cord-256918-mauzesor	48	26	,	,	,
cord-256918-mauzesor	48	27	influences	influence	VBZ
cord-256918-mauzesor	48	28	the	the	DT
cord-256918-mauzesor	48	29	pathogenic	pathogenic	JJ
cord-256918-mauzesor	48	30	potential	potential	NN
cord-256918-mauzesor	48	31	of	of	IN
cord-256918-mauzesor	48	32	this	this	DT
cord-256918-mauzesor	48	33	virus	virus	NN
cord-256918-mauzesor	48	34	in	in	IN
cord-256918-mauzesor	48	35	mice	mouse	NNS
cord-256918-mauzesor	48	36	.	.	.
cord-256918-mauzesor	49	1	In	in	IN
cord-256918-mauzesor	49	2	the	the	DT
cord-256918-mauzesor	49	3	extended	extended	JJ
cord-256918-mauzesor	49	4	definition	definition	NN
cord-256918-mauzesor	49	5	,	,	,
cord-256918-mauzesor	49	6	useful	useful	JJ
cord-256918-mauzesor	49	7	to	to	IN
cord-256918-mauzesor	49	8	virology	virology	NN
cord-256918-mauzesor	49	9	,	,	,
cord-256918-mauzesor	49	10	quasispecies	quasispecie	NNS
cord-256918-mauzesor	49	11	are	be	VBP
cord-256918-mauzesor	49	12	dynamic	dynamic	JJ
cord-256918-mauzesor	49	13	distributions	distribution	NNS
cord-256918-mauzesor	49	14	of	of	IN
cord-256918-mauzesor	49	15	non	non	JJ
cord-256918-mauzesor	49	16	-	-	JJ
cord-256918-mauzesor	49	17	identical	identical	JJ
cord-256918-mauzesor	49	18	but	but	CC
cord-256918-mauzesor	49	19	closely	closely	RB
cord-256918-mauzesor	49	20	-	-	HYPH
cord-256918-mauzesor	49	21	related	relate	VBN
cord-256918-mauzesor	49	22	mutant	mutant	JJ
cord-256918-mauzesor	49	23	and	and	CC
cord-256918-mauzesor	49	24	recombinant	recombinant	JJ
cord-256918-mauzesor	49	25	viral	viral	JJ
cord-256918-mauzesor	49	26	genomes	genome	NNS
cord-256918-mauzesor	49	27	.	.	.
cord-256918-mauzesor	50	1	They	-PRON-	PRP
cord-256918-mauzesor	50	2	are	be	VBP
cord-256918-mauzesor	50	3	subjected	subject	VBN
cord-256918-mauzesor	50	4	to	to	IN
cord-256918-mauzesor	50	5	a	a	DT
cord-256918-mauzesor	50	6	continuous	continuous	JJ
cord-256918-mauzesor	50	7	process	process	NN
cord-256918-mauzesor	50	8	of	of	IN
cord-256918-mauzesor	50	9	genetic	genetic	JJ
cord-256918-mauzesor	50	10	variation	variation	NN
cord-256918-mauzesor	50	11	,	,	,
cord-256918-mauzesor	50	12	competition	competition	NN
cord-256918-mauzesor	50	13	and	and	CC
cord-256918-mauzesor	50	14	selection	selection	NN
cord-256918-mauzesor	50	15	,	,	,
cord-256918-mauzesor	50	16	and	and	CC
cord-256918-mauzesor	50	17	act	act	VB
cord-256918-mauzesor	50	18	as	as	IN
cord-256918-mauzesor	50	19	a	a	DT
cord-256918-mauzesor	50	20	unit	unit	NN
cord-256918-mauzesor	50	21	of	of	IN
cord-256918-mauzesor	50	22	selection	selection	NN
cord-256918-mauzesor	50	23	.	.	.
cord-256918-mauzesor	51	1	The	the	DT
cord-256918-mauzesor	51	2	links	link	NNS
cord-256918-mauzesor	51	3	between	between	IN
cord-256918-mauzesor	51	4	the	the	DT
cord-256918-mauzesor	51	5	original	original	JJ
cord-256918-mauzesor	51	6	theoretical	theoretical	JJ
cord-256918-mauzesor	51	7	quasispecies	quasispecie	NNS
cord-256918-mauzesor	51	8	concept	concept	NN
cord-256918-mauzesor	51	9	and	and	CC
cord-256918-mauzesor	51	10	viral	viral	JJ
cord-256918-mauzesor	51	11	quasispecies	quasispecie	NNS
cord-256918-mauzesor	51	12	have	have	VBP
cord-256918-mauzesor	51	13	been	be	VBN
cord-256918-mauzesor	51	14	discussed	discuss	VBN
cord-256918-mauzesor	51	15	in	in	IN
cord-256918-mauzesor	51	16	several	several	JJ
cord-256918-mauzesor	51	17	recent	recent	JJ
cord-256918-mauzesor	51	18	papers	paper	NNS
cord-256918-mauzesor	51	19	Eigen	Eigen	NNP
cord-256918-mauzesor	51	20	,	,	,
cord-256918-mauzesor	51	21	1996	1996	CD
cord-256918-mauzesor	51	22	;	;	:
cord-256918-mauzesor	51	23	.	.	.
cord-256918-mauzesor	52	1	If	if	IN
cord-256918-mauzesor	52	2	Eigen	Eigen	NNP
cord-256918-mauzesor	52	3	's	's	POS
cord-256918-mauzesor	52	4	model	model	NN
cord-256918-mauzesor	52	5	had	have	VBD
cord-256918-mauzesor	52	6	not	not	RB
cord-256918-mauzesor	52	7	been	be	VBN
cord-256918-mauzesor	52	8	formulated	formulate	VBN
cord-256918-mauzesor	52	9	it	-PRON-	PRP
cord-256918-mauzesor	52	10	would	would	MD
cord-256918-mauzesor	52	11	be	be	VB
cord-256918-mauzesor	52	12	difficult	difficult	JJ
cord-256918-mauzesor	52	13	to	to	TO
cord-256918-mauzesor	52	14	reconcile	reconcile	VB
cord-256918-mauzesor	52	15	many	many	JJ
cord-256918-mauzesor	52	16	observations	observation	NNS
cord-256918-mauzesor	52	17	on	on	IN
cord-256918-mauzesor	52	18	genotypic	genotypic	JJ
cord-256918-mauzesor	52	19	and	and	CC
cord-256918-mauzesor	52	20	phenotypic	phenotypic	JJ
cord-256918-mauzesor	52	21	variations	variation	NNS
cord-256918-mauzesor	52	22	of	of	IN
cord-256918-mauzesor	52	23	RNA	RNA	NNP
cord-256918-mauzesor	52	24	viruses	virus	NNS
cord-256918-mauzesor	52	25	.	.	.
cord-256918-mauzesor	53	1	Biological	biological	JJ
cord-256918-mauzesor	53	2	implications	implication	NNS
cord-256918-mauzesor	53	3	of	of	IN
cord-256918-mauzesor	53	4	quasispecies	quasispecie	NNS
cord-256918-mauzesor	53	5	extend	extend	VBP
cord-256918-mauzesor	53	6	from	from	IN
cord-256918-mauzesor	53	7	viral	viral	JJ
cord-256918-mauzesor	53	8	pathogenesis	pathogenesis	NN
cord-256918-mauzesor	53	9	to	to	IN
cord-256918-mauzesor	53	10	the	the	DT
cord-256918-mauzesor	53	11	emergence	emergence	NN
cord-256918-mauzesor	53	12	of	of	IN
cord-256918-mauzesor	53	13	new	new	JJ
cord-256918-mauzesor	53	14	viral	viral	JJ
cord-256918-mauzesor	53	15	pathogens	pathogen	NNS
cord-256918-mauzesor	53	16	(	(	-LRB-
cord-256918-mauzesor	53	17	Morse	Morse	NNP
cord-256918-mauzesor	53	18	,	,	,
cord-256918-mauzesor	53	19	1993	1993	CD
cord-256918-mauzesor	53	20	)	)	-RRB-
cord-256918-mauzesor	53	21	.	.	.
cord-256918-mauzesor	54	1	They	-PRON-	PRP
cord-256918-mauzesor	54	2	include	include	VBP
cord-256918-mauzesor	54	3	rapid	rapid	JJ
cord-256918-mauzesor	54	4	antigenic	antigenic	JJ
cord-256918-mauzesor	54	5	variation	variation	NN
cord-256918-mauzesor	54	6	(	(	-LRB-
cord-256918-mauzesor	54	7	antibody	antibody	NN
cord-256918-mauzesor	54	8	-	-	HYPH
cord-256918-mauzesor	54	9	escape	escape	NN
cord-256918-mauzesor	54	10	and	and	CC
cord-256918-mauzesor	54	11	cytotoxic	cytotoxic	JJ
cord-256918-mauzesor	54	12	T	t	NN
cord-256918-mauzesor	54	13	-	-	HYPH
cord-256918-mauzesor	54	14	lymphocyte	lymphocyte	NN
cord-256918-mauzesor	54	15	(	(	-LRB-
cord-256918-mauzesor	54	16	CTL)-escape	CTL)-escape	''
cord-256918-mauzesor	54	17	)	)	-RRB-
cord-256918-mauzesor	54	18	,	,	,
cord-256918-mauzesor	54	19	alterations	alteration	NNS
cord-256918-mauzesor	54	20	in	in	IN
cord-256918-mauzesor	54	21	cell	cell	NN
cord-256918-mauzesor	54	22	tropism	tropism	NN
cord-256918-mauzesor	54	23	,	,	,
cord-256918-mauzesor	54	24	virulence	virulence	NN
cord-256918-mauzesor	54	25	,	,	,
cord-256918-mauzesor	54	26	host	host	NN
cord-256918-mauzesor	54	27	range	range	NN
cord-256918-mauzesor	54	28	and	and	CC
cord-256918-mauzesor	54	29	viral	viral	JJ
cord-256918-mauzesor	54	30	gene	gene	NN
cord-256918-mauzesor	54	31	expression	expression	NN
cord-256918-mauzesor	54	32	(	(	-LRB-
cord-256918-mauzesor	54	33	Domingo	Domingo	NNP
cord-256918-mauzesor	54	34	,	,	,
cord-256918-mauzesor	54	35	1989	1989	CD
cord-256918-mauzesor	54	36	(	(	-LRB-
cord-256918-mauzesor	54	37	Domingo	Domingo	NNP
cord-256918-mauzesor	54	38	,	,	,
cord-256918-mauzesor	54	39	,	,	,
cord-256918-mauzesor	54	40	1996	1996	CD
cord-256918-mauzesor	54	41	Jackson	Jackson	NNP
cord-256918-mauzesor	54	42	et	et	NNP
cord-256918-mauzesor	54	43	al	al	NNP
cord-256918-mauzesor	54	44	.	.	.
cord-256918-mauzesor	55	1	,	,	,
cord-256918-mauzesor	55	2	1996	1996	CD
cord-256918-mauzesor	55	3	;	;	:
cord-256918-mauzesor	55	4	Sa	Sa	NNP
cord-256918-mauzesor	55	5	-	-	HYPH
cord-256918-mauzesor	55	6	Carvalho	Carvalho	NNP
cord-256918-mauzesor	55	7	et	et	FW
cord-256918-mauzesor	55	8	al	al	NNP
cord-256918-mauzesor	55	9	.	.	NNP
cord-256918-mauzesor	55	10	,	,	,
cord-256918-mauzesor	55	11	1997	1997	CD
cord-256918-mauzesor	55	12	)	)	-RRB-
cord-256918-mauzesor	56	1	(	(	-LRB-
cord-256918-mauzesor	56	2	Table	table	NN
cord-256918-mauzesor	56	3	1	1	CD
cord-256918-mauzesor	56	4	)	)	-RRB-
cord-256918-mauzesor	56	5	.	.	.
cord-256918-mauzesor	57	1	One	one	CD
cord-256918-mauzesor	57	2	of	of	IN
cord-256918-mauzesor	57	3	the	the	DT
cord-256918-mauzesor	57	4	most	most	RBS
cord-256918-mauzesor	57	5	obvious	obvious	JJ
cord-256918-mauzesor	57	6	consequences	consequence	NNS
cord-256918-mauzesor	57	7	of	of	IN
cord-256918-mauzesor	57	8	quasispecies	quasispecie	NNS
cord-256918-mauzesor	57	9	structure	structure	NN
cord-256918-mauzesor	57	10	is	be	VBZ
cord-256918-mauzesor	57	11	the	the	DT
cord-256918-mauzesor	57	12	genetic	genetic	JJ
cord-256918-mauzesor	57	13	and	and	CC
cord-256918-mauzesor	57	14	antigenic	antigenic	JJ
cord-256918-mauzesor	57	15	diversification	diversification	NN
cord-256918-mauzesor	57	16	of	of	IN
cord-256918-mauzesor	57	17	RNA	RNA	NNP
cord-256918-mauzesor	57	18	viruses	virus	NNS
cord-256918-mauzesor	57	19	in	in	IN
cord-256918-mauzesor	57	20	nature	nature	NN
cord-256918-mauzesor	57	21	.	.	.
cord-256918-mauzesor	58	1	This	this	DT
cord-256918-mauzesor	58	2	has	have	VBZ
cord-256918-mauzesor	58	3	triggered	trigger	VBN
cord-256918-mauzesor	58	4	efforts	effort	NNS
cord-256918-mauzesor	58	5	to	to	TO
cord-256918-mauzesor	58	6	classify	classify	VB
cord-256918-mauzesor	58	7	any	any	DT
cord-256918-mauzesor	58	8	viral	viral	JJ
cord-256918-mauzesor	58	9	pathogen	pathogen	NN
cord-256918-mauzesor	58	10	into	into	IN
cord-256918-mauzesor	58	11	different	different	JJ
cord-256918-mauzesor	58	12	types	type	NNS
cord-256918-mauzesor	58	13	or	or	CC
cord-256918-mauzesor	58	14	subtypes	subtype	NNS
cord-256918-mauzesor	58	15	.	.	.
cord-256918-mauzesor	59	1	While	while	IN
cord-256918-mauzesor	59	2	classification	classification	NN
cord-256918-mauzesor	59	3	has	have	VBZ
cord-256918-mauzesor	59	4	clear	clear	JJ
cord-256918-mauzesor	59	5	advantages	advantage	NNS
cord-256918-mauzesor	59	6	for	for	IN
cord-256918-mauzesor	59	7	diagnostic	diagnostic	JJ
cord-256918-mauzesor	59	8	,	,	,
cord-256918-mauzesor	59	9	clinical	clinical	JJ
cord-256918-mauzesor	59	10	and	and	CC
cord-256918-mauzesor	59	11	epidemiological	epidemiological	JJ
cord-256918-mauzesor	59	12	work	work	NN
cord-256918-mauzesor	59	13	,	,	,
cord-256918-mauzesor	59	14	it	-PRON-	PRP
cord-256918-mauzesor	59	15	tends	tend	VBZ
cord-256918-mauzesor	59	16	to	to	TO
cord-256918-mauzesor	59	17	assign	assign	VB
cord-256918-mauzesor	59	18	,	,	,
cord-256918-mauzesor	59	19	to	to	IN
cord-256918-mauzesor	59	20	particular	particular	JJ
cord-256918-mauzesor	59	21	viral	viral	JJ
cord-256918-mauzesor	59	22	groups	group	NNS
cord-256918-mauzesor	59	23	,	,	,
cord-256918-mauzesor	59	24	some	some	DT
cord-256918-mauzesor	59	25	biological	biological	JJ
cord-256918-mauzesor	59	26	properties	property	NNS
cord-256918-mauzesor	59	27	unlikely	unlikely	JJ
cord-256918-mauzesor	59	28	to	to	TO
cord-256918-mauzesor	59	29	be	be	VB
cord-256918-mauzesor	59	30	valid	valid	JJ
cord-256918-mauzesor	59	31	as	as	IN
cord-256918-mauzesor	59	32	additional	additional	JJ
cord-256918-mauzesor	59	33	isolates	isolate	NNS
cord-256918-mauzesor	59	34	are	be	VBP
cord-256918-mauzesor	59	35	included	include	VBN
cord-256918-mauzesor	59	36	in	in	IN
cord-256918-mauzesor	59	37	the	the	DT
cord-256918-mauzesor	59	38	collections	collection	NNS
cord-256918-mauzesor	59	39	.	.	.
cord-256918-mauzesor	60	1	An	an	DT
cord-256918-mauzesor	60	2	example	example	NN
cord-256918-mauzesor	60	3	is	be	VBZ
cord-256918-mauzesor	60	4	the	the	DT
cord-256918-mauzesor	60	5	subtyping	subtyping	NN
cord-256918-mauzesor	60	6	of	of	IN
cord-256918-mauzesor	60	7	FMDV	FMDV	NNP
cord-256918-mauzesor	60	8	.	.	.
cord-256918-mauzesor	61	1	This	this	DT
cord-256918-mauzesor	61	2	was	be	VBD
cord-256918-mauzesor	61	3	stopped	stop	VBN
cord-256918-mauzesor	61	4	two	two	CD
cord-256918-mauzesor	61	5	decades	decade	NNS
cord-256918-mauzesor	61	6	ago	ago	RB
cord-256918-mauzesor	61	7	when	when	WRB
cord-256918-mauzesor	61	8	,	,	,
cord-256918-mauzesor	61	9	after	after	IN
cord-256918-mauzesor	61	10	having	have	VBG
cord-256918-mauzesor	61	11	isolated	isolate	VBN
cord-256918-mauzesor	61	12	a	a	DT
cord-256918-mauzesor	61	13	representative	representative	NN
cord-256918-mauzesor	61	14	of	of	IN
cord-256918-mauzesor	61	15	subtype	subtype	NN
cord-256918-mauzesor	61	16	65	65	CD
cord-256918-mauzesor	61	17	,	,	,
cord-256918-mauzesor	61	18	it	-PRON-	PRP
cord-256918-mauzesor	61	19	was	be	VBD
cord-256918-mauzesor	61	20	realised	realise	VBN
cord-256918-mauzesor	61	21	that	that	IN
cord-256918-mauzesor	61	22	virtually	virtually	RB
cord-256918-mauzesor	61	23	any	any	DT
cord-256918-mauzesor	61	24	isolate	isolate	NN
cord-256918-mauzesor	61	25	could	could	MD
cord-256918-mauzesor	61	26	be	be	VB
cord-256918-mauzesor	61	27	classified	classify	VBN
cord-256918-mauzesor	61	28	as	as	IN
cord-256918-mauzesor	61	29	a	a	DT
cord-256918-mauzesor	61	30	new	new	JJ
cord-256918-mauzesor	61	31	subtype	subtype	NN
cord-256918-mauzesor	61	32	.	.	.
cord-256918-mauzesor	62	1	It	-PRON-	PRP
cord-256918-mauzesor	62	2	was	be	VBD
cord-256918-mauzesor	62	3	found	find	VBN
cord-256918-mauzesor	62	4	that	that	IN
cord-256918-mauzesor	62	5	additional	additional	JJ
cord-256918-mauzesor	62	6	antibodies	antibody	NNS
cord-256918-mauzesor	62	7	allowed	allow	VBD
cord-256918-mauzesor	62	8	increased	increase	VBN
cord-256918-mauzesor	62	9	discrimination	discrimination	NN
cord-256918-mauzesor	62	10	among	among	IN
cord-256918-mauzesor	62	11	isolates	isolate	NNS
cord-256918-mauzesor	62	12	.	.	.
cord-256918-mauzesor	63	1	Viral	viral	JJ
cord-256918-mauzesor	63	2	types	type	NNS
cord-256918-mauzesor	63	3	and	and	CC
cord-256918-mauzesor	63	4	subtypes	subtype	NNS
cord-256918-mauzesor	63	5	are	be	VBP
cord-256918-mauzesor	63	6	just	just	RB
cord-256918-mauzesor	63	7	the	the	DT
cord-256918-mauzesor	63	8	'	'	``
cord-256918-mauzesor	63	9	tip	tip	NN
cord-256918-mauzesor	63	10	of	of	IN
cord-256918-mauzesor	63	11	the	the	DT
cord-256918-mauzesor	63	12	iceberg	iceberg	NN
cord-256918-mauzesor	63	13	'	'	''
cord-256918-mauzesor	63	14	of	of	IN
cord-256918-mauzesor	63	15	a	a	DT
cord-256918-mauzesor	63	16	more	more	RBR
cord-256918-mauzesor	63	17	profound	profound	JJ
cord-256918-mauzesor	63	18	and	and	CC
cord-256918-mauzesor	63	19	fundamental	fundamental	JJ
cord-256918-mauzesor	63	20	phenomenon	phenomenon	NN
cord-256918-mauzesor	63	21	:	:	:
cord-256918-mauzesor	63	22	the	the	DT
cord-256918-mauzesor	63	23	continuous	continuous	JJ
cord-256918-mauzesor	63	24	dynamics	dynamic	NNS
cord-256918-mauzesor	63	25	of	of	IN
cord-256918-mauzesor	63	26	mutant	mutant	JJ
cord-256918-mauzesor	63	27	generation	generation	NN
cord-256918-mauzesor	63	28	,	,	,
cord-256918-mauzesor	63	29	competition	competition	NN
cord-256918-mauzesor	63	30	,	,	,
cord-256918-mauzesor	63	31	selection	selection	NN
cord-256918-mauzesor	63	32	and	and	CC
cord-256918-mauzesor	63	33	random	random	JJ
cord-256918-mauzesor	63	34	events	event	NNS
cord-256918-mauzesor	63	35	which	which	WDT
cord-256918-mauzesor	63	36	push	push	VBP
cord-256918-mauzesor	63	37	viral	viral	JJ
cord-256918-mauzesor	63	38	quasispecies	quasispecie	NNS
cord-256918-mauzesor	63	39	towards	towards	IN
cord-256918-mauzesor	63	40	diversification	diversification	NN
cord-256918-mauzesor	63	41	.	.	.
cord-256918-mauzesor	64	1	In	in	IN
cord-256918-mauzesor	64	2	some	some	DT
cord-256918-mauzesor	64	3	cases	case	NNS
cord-256918-mauzesor	64	4	serological	serological	JJ
cord-256918-mauzesor	64	5	classifications	classification	NNS
cord-256918-mauzesor	64	6	(	(	-LRB-
cord-256918-mauzesor	64	7	and	and	CC
cord-256918-mauzesor	64	8	possibly	possibly	RB
cord-256918-mauzesor	64	9	phylogenetic	phylogenetic	JJ
cord-256918-mauzesor	64	10	classifications	classification	NNS
cord-256918-mauzesor	64	11	)	)	-RRB-
cord-256918-mauzesor	64	12	may	may	MD
cord-256918-mauzesor	64	13	bear	bear	VB
cord-256918-mauzesor	64	14	a	a	DT
cord-256918-mauzesor	64	15	useful	useful	JJ
cord-256918-mauzesor	64	16	relatedness	relatedness	NN
cord-256918-mauzesor	64	17	with	with	IN
cord-256918-mauzesor	64	18	other	other	JJ
cord-256918-mauzesor	64	19	biological	biological	JJ
cord-256918-mauzesor	64	20	traits	trait	NNS
cord-256918-mauzesor	64	21	.	.	.
cord-256918-mauzesor	65	1	Based	base	VBN
cord-256918-mauzesor	65	2	on	on	IN
cord-256918-mauzesor	65	3	increasing	increase	VBG
cord-256918-mauzesor	65	4	,	,	,
cord-256918-mauzesor	65	5	but	but	CC
cord-256918-mauzesor	65	6	as	as	RB
cord-256918-mauzesor	65	7	yet	yet	RB
cord-256918-mauzesor	65	8	incomplete	incomplete	JJ
cord-256918-mauzesor	65	9	,	,	,
cord-256918-mauzesor	65	10	evidence	evidence	NN
cord-256918-mauzesor	65	11	it	-PRON-	PRP
cord-256918-mauzesor	65	12	can	can	MD
cord-256918-mauzesor	65	13	be	be	VB
cord-256918-mauzesor	65	14	suggested	suggest	VBN
cord-256918-mauzesor	65	15	that	that	IN
cord-256918-mauzesor	65	16	residues	residue	NNS
cord-256918-mauzesor	65	17	of	of	IN
cord-256918-mauzesor	65	18	antigenic	antigenic	JJ
cord-256918-mauzesor	65	19	sites	site	NNS
cord-256918-mauzesor	65	20	will	will	MD
cord-256918-mauzesor	65	21	frequently	frequently	RB
cord-256918-mauzesor	65	22	have	have	VB
cord-256918-mauzesor	65	23	some	some	DT
cord-256918-mauzesor	65	24	influence	influence	NN
cord-256918-mauzesor	65	25	on	on	IN
cord-256918-mauzesor	65	26	cell	cell	NN
cord-256918-mauzesor	65	27	receptor	receptor	NN
cord-256918-mauzesor	65	28	recognition	recognition	NN
cord-256918-mauzesor	65	29	(	(	-LRB-
cord-256918-mauzesor	65	30	Harber	Harber	NNP
cord-256918-mauzesor	65	31	et	et	NNP
cord-256918-mauzesor	65	32	al	al	NNP
cord-256918-mauzesor	65	33	.	.	NNP
cord-256918-mauzesor	65	34	,	,	,
cord-256918-mauzesor	65	35	1995	1995	CD
cord-256918-mauzesor	65	36	)	)	-RRB-
cord-256918-mauzesor	65	37	.	.	.
cord-256918-mauzesor	66	1	Amino	amino	NN
cord-256918-mauzesor	66	2	acid	acid	NN
cord-256918-mauzesor	66	3	residues	residue	NNS
cord-256918-mauzesor	66	4	of	of	IN
cord-256918-mauzesor	66	5	antigenic	antigenic	JJ
cord-256918-mauzesor	66	6	sites	site	NNS
cord-256918-mauzesor	66	7	tend	tend	VBP
cord-256918-mauzesor	66	8	to	to	TO
cord-256918-mauzesor	66	9	be	be	VB
cord-256918-mauzesor	66	10	located	locate	VBN
cord-256918-mauzesor	66	11	at	at	IN
cord-256918-mauzesor	66	12	exposed	expose	VBN
cord-256918-mauzesor	66	13	areas	area	NNS
cord-256918-mauzesor	66	14	on	on	IN
cord-256918-mauzesor	66	15	viral	viral	JJ
cord-256918-mauzesor	66	16	capsids	capsid	NNS
cord-256918-mauzesor	66	17	and	and	CC
cord-256918-mauzesor	66	18	surface	surface	NN
cord-256918-mauzesor	66	19	proteins	protein	NNS
cord-256918-mauzesor	66	20	,	,	,
cord-256918-mauzesor	66	21	a	a	DT
cord-256918-mauzesor	66	22	suitable	suitable	JJ
cord-256918-mauzesor	66	23	location	location	NN
cord-256918-mauzesor	66	24	to	to	TO
cord-256918-mauzesor	66	25	exert	exert	VB
cord-256918-mauzesor	66	26	influence	influence	NN
cord-256918-mauzesor	66	27	on	on	IN
cord-256918-mauzesor	66	28	the	the	DT
cord-256918-mauzesor	66	29	interaction	interaction	NN
cord-256918-mauzesor	66	30	of	of	IN
cord-256918-mauzesor	66	31	viruses	virus	NNS
cord-256918-mauzesor	66	32	with	with	IN
cord-256918-mauzesor	66	33	receptors	receptor	NNS
cord-256918-mauzesor	66	34	.	.	.
cord-256918-mauzesor	67	1	This	this	DT
cord-256918-mauzesor	67	2	coincidence	coincidence	NN
cord-256918-mauzesor	67	3	of	of	IN
cord-256918-mauzesor	67	4	locations	location	NNS
cord-256918-mauzesor	67	5	may	may	MD
cord-256918-mauzesor	67	6	establish	establish	VB
cord-256918-mauzesor	67	7	some	some	DT
cord-256918-mauzesor	67	8	coevolution	coevolution	NN
cord-256918-mauzesor	67	9	of	of	IN
cord-256918-mauzesor	67	10	antigenicity	antigenicity	NN
cord-256918-mauzesor	67	11	and	and	CC
cord-256918-mauzesor	67	12	host	host	NN
cord-256918-mauzesor	67	13	range	range	NN
cord-256918-mauzesor	67	14	.	.	.
cord-256918-mauzesor	68	1	In	in	IN
cord-256918-mauzesor	68	2	many	many	JJ
cord-256918-mauzesor	68	3	other	other	JJ
cord-256918-mauzesor	68	4	cases	case	NNS
cord-256918-mauzesor	68	5	,	,	,
cord-256918-mauzesor	68	6	however	however	RB
cord-256918-mauzesor	68	7	,	,	,
cord-256918-mauzesor	68	8	biological	biological	JJ
cord-256918-mauzesor	68	9	features	feature	VBZ
cord-256918-mauzesor	68	10	dependent	dependent	JJ
cord-256918-mauzesor	68	11	on	on	IN
cord-256918-mauzesor	68	12	one	one	CD
cord-256918-mauzesor	68	13	or	or	CC
cord-256918-mauzesor	68	14	more	more	JJR
cord-256918-mauzesor	68	15	nucleotide	nucleotide	JJ
cord-256918-mauzesor	68	16	or	or	CC
cord-256918-mauzesor	68	17	amino	amino	NN
cord-256918-mauzesor	68	18	acid	acid	NN
cord-256918-mauzesor	68	19	substitutions	substitution	NNS
cord-256918-mauzesor	68	20	,	,	,
cord-256918-mauzesor	68	21	will	will	MD
cord-256918-mauzesor	68	22	not	not	RB
cord-256918-mauzesor	68	23	correspond	correspond	VB
cord-256918-mauzesor	68	24	to	to	IN
cord-256918-mauzesor	68	25	any	any	DT
cord-256918-mauzesor	68	26	phylogenetic	phylogenetic	JJ
cord-256918-mauzesor	68	27	classification	classification	NN
cord-256918-mauzesor	68	28	based	base	VBN
cord-256918-mauzesor	68	29	on	on	IN
cord-256918-mauzesor	68	30	entire	entire	JJ
cord-256918-mauzesor	68	31	genomes	genome	NNS
cord-256918-mauzesor	68	32	or	or	CC
cord-256918-mauzesor	68	33	selected	select	VBN
cord-256918-mauzesor	68	34	genomic	genomic	JJ
cord-256918-mauzesor	68	35	regions	region	NNS
cord-256918-mauzesor	68	36	.	.	.
cord-256918-mauzesor	69	1	Control	control	NN
cord-256918-mauzesor	69	2	of	of	IN
cord-256918-mauzesor	69	3	diseases	disease	NNS
cord-256918-mauzesor	69	4	caused	cause	VBN
cord-256918-mauzesor	69	5	by	by	IN
cord-256918-mauzesor	69	6	highly	highly	RB
cord-256918-mauzesor	69	7	variable	variable	JJ
cord-256918-mauzesor	69	8	RNA	RNA	NNP
cord-256918-mauzesor	69	9	viruses	virus	NNS
cord-256918-mauzesor	69	10	is	be	VBZ
cord-256918-mauzesor	69	11	not	not	RB
cord-256918-mauzesor	69	12	currently	currently	RB
cord-256918-mauzesor	69	13	successful	successful	JJ
cord-256918-mauzesor	69	14	.	.	.
cord-256918-mauzesor	70	1	For	for	IN
cord-256918-mauzesor	70	2	important	important	JJ
cord-256918-mauzesor	70	3	diseases	disease	NNS
cord-256918-mauzesor	70	4	(	(	-LRB-
cord-256918-mauzesor	70	5	such	such	JJ
cord-256918-mauzesor	70	6	as	as	IN
cord-256918-mauzesor	70	7	acquired	acquire	VBN
cord-256918-mauzesor	70	8	immune	immune	JJ
cord-256918-mauzesor	70	9	deficiency	deficiency	NN
cord-256918-mauzesor	70	10	syndrome	syndrome	NN
cord-256918-mauzesor	70	11	(	(	-LRB-
cord-256918-mauzesor	70	12	AIDS	AIDS	NNP
cord-256918-mauzesor	70	13	)	)	-RRB-
cord-256918-mauzesor	70	14	or	or	CC
cord-256918-mauzesor	70	15	hepatitis	hepatitis	NN
cord-256918-mauzesor	70	16	associated	associate	VBN
cord-256918-mauzesor	70	17	with	with	IN
cord-256918-mauzesor	70	18	hepatitis	hepatitis	NN
cord-256918-mauzesor	70	19	C	C	NNP
cord-256918-mauzesor	70	20	virus	virus	NN
cord-256918-mauzesor	70	21	(	(	-LRB-
cord-256918-mauzesor	70	22	HCV	HCV	NNP
cord-256918-mauzesor	70	23	)	)	-RRB-
cord-256918-mauzesor	70	24	)	)	-RRB-
cord-256918-mauzesor	71	1	no	no	DT
cord-256918-mauzesor	71	2	vaccines	vaccine	NNS
cord-256918-mauzesor	71	3	are	be	VBP
cord-256918-mauzesor	71	4	available	available	JJ
cord-256918-mauzesor	71	5	.	.	.
cord-256918-mauzesor	72	1	Selection	selection	NN
cord-256918-mauzesor	72	2	of	of	IN
cord-256918-mauzesor	72	3	inhibitor	inhibitor	NN
cord-256918-mauzesor	72	4	-	-	HYPH
cord-256918-mauzesor	72	5	resistant	resistant	JJ
cord-256918-mauzesor	72	6	viral	viral	JJ
cord-256918-mauzesor	72	7	mutants	mutant	NNS
cord-256918-mauzesor	72	8	is	be	VBZ
cord-256918-mauzesor	72	9	the	the	DT
cord-256918-mauzesor	72	10	norm	norm	NN
cord-256918-mauzesor	72	11	rather	rather	RB
cord-256918-mauzesor	72	12	than	than	IN
cord-256918-mauzesor	72	13	the	the	DT
cord-256918-mauzesor	72	14	exception	exception	NN
cord-256918-mauzesor	72	15	(	(	-LRB-
cord-256918-mauzesor	72	16	Domingo	Domingo	NNP
cord-256918-mauzesor	72	17	,	,	,
cord-256918-mauzesor	72	18	1989	1989	CD
cord-256918-mauzesor	72	19	;	;	:
cord-256918-mauzesor	72	20	Domingo	Domingo	NNP
cord-256918-mauzesor	72	21	and	and	CC
cord-256918-mauzesor	72	22	Holland	Holland	NNP
cord-256918-mauzesor	72	23	,	,	,
cord-256918-mauzesor	72	24	1992	1992	CD
cord-256918-mauzesor	72	25	;	;	:
cord-256918-mauzesor	72	26	Morse	Morse	NNP
cord-256918-mauzesor	72	27	,	,	,
cord-256918-mauzesor	72	28	1993	1993	CD
cord-256918-mauzesor	72	29	)	)	-RRB-
cord-256918-mauzesor	72	30	.	.	.
cord-256918-mauzesor	73	1	Failures	failure	NNS
cord-256918-mauzesor	73	2	have	have	VBP
cord-256918-mauzesor	73	3	triggered	trigger	VBN
cord-256918-mauzesor	73	4	strong	strong	JJ
cord-256918-mauzesor	73	5	claims	claim	NNS
cord-256918-mauzesor	73	6	that	that	IN
cord-256918-mauzesor	73	7	a	a	DT
cord-256918-mauzesor	73	8	radical	radical	JJ
cord-256918-mauzesor	73	9	change	change	NN
cord-256918-mauzesor	73	10	in	in	IN
cord-256918-mauzesor	73	11	strategy	strategy	NN
cord-256918-mauzesor	73	12	to	to	TO
cord-256918-mauzesor	73	13	combat	combat	VB
cord-256918-mauzesor	73	14	viral	viral	JJ
cord-256918-mauzesor	73	15	disease	disease	NN
cord-256918-mauzesor	73	16	is	be	VBZ
cord-256918-mauzesor	73	17	needed	need	VBN
cord-256918-mauzesor	73	18	(	(	-LRB-
cord-256918-mauzesor	73	19	Lederberg	Lederberg	NNP
cord-256918-mauzesor	73	20	et	et	FW
cord-256918-mauzesor	73	21	al	al	NNP
cord-256918-mauzesor	73	22	.	.	NNP
cord-256918-mauzesor	73	23	,	,	,
cord-256918-mauzesor	73	24	1992	1992	CD
cord-256918-mauzesor	73	25	;	;	:
cord-256918-mauzesor	73	26	Kunin	Kunin	NNP
cord-256918-mauzesor	73	27	,	,	,
cord-256918-mauzesor	73	28	1993	1993	CD
cord-256918-mauzesor	73	29	;	;	:
cord-256918-mauzesor	73	30	Morse	Morse	NNP
cord-256918-mauzesor	73	31	,	,	,
cord-256918-mauzesor	73	32	1994	1994	CD
cord-256918-mauzesor	73	33	;	;	:
cord-256918-mauzesor	73	34	Casadevall	Casadevall	NNP
cord-256918-mauzesor	73	35	,	,	,
cord-256918-mauzesor	73	36	1996	1996	CD
cord-256918-mauzesor	73	37	;	;	:
cord-256918-mauzesor	73	38	.	.	.
cord-256918-mauzesor	74	1	Part	part	NN
cord-256918-mauzesor	74	2	of	of	IN
cord-256918-mauzesor	74	3	the	the	DT
cord-256918-mauzesor	74	4	problem	problem	NN
cord-256918-mauzesor	74	5	lies	lie	VBZ
cord-256918-mauzesor	74	6	in	in	IN
cord-256918-mauzesor	74	7	the	the	DT
cord-256918-mauzesor	74	8	quasispecies	quasispecies	NNP
cord-256918-mauzesor	74	9	nature	nature	NN
cord-256918-mauzesor	74	10	of	of	IN
cord-256918-mauzesor	74	11	the	the	DT
cord-256918-mauzesor	74	12	RNA	RNA	NNP
cord-256918-mauzesor	74	13	viral	viral	JJ
cord-256918-mauzesor	74	14	agents	agent	NNS
cord-256918-mauzesor	74	15	.	.	.
cord-256918-mauzesor	75	1	Another	another	DT
cord-256918-mauzesor	75	2	problem	problem	NN
cord-256918-mauzesor	75	3	is	be	VBZ
cord-256918-mauzesor	75	4	the	the	DT
cord-256918-mauzesor	75	5	still	still	RB
cord-256918-mauzesor	75	6	rudimentary	rudimentary	JJ
cord-256918-mauzesor	75	7	knowledge	knowledge	NN
cord-256918-mauzesor	75	8	of	of	IN
cord-256918-mauzesor	75	9	the	the	DT
cord-256918-mauzesor	75	10	immune	immune	JJ
cord-256918-mauzesor	75	11	system	system	NN
cord-256918-mauzesor	75	12	and	and	CC
cord-256918-mauzesor	75	13	immune	immune	JJ
cord-256918-mauzesor	75	14	responses	response	NNS
cord-256918-mauzesor	75	15	.	.	.
cord-256918-mauzesor	76	1	Quasispecies	quasispecie	NNS
cord-256918-mauzesor	76	2	offer	offer	VBP
cord-256918-mauzesor	76	3	alternatives	alternative	NNS
cord-256918-mauzesor	76	4	for	for	IN
cord-256918-mauzesor	76	5	improving	improve	VBG
cord-256918-mauzesor	76	6	disease	disease	NN
cord-256918-mauzesor	76	7	prevention	prevention	NN
cord-256918-mauzesor	76	8	and	and	CC
cord-256918-mauzesor	76	9	treatments	treatment	NNS
cord-256918-mauzesor	77	1	(	(	-LRB-
cord-256918-mauzesor	77	2	Novella	novella	NN
cord-256918-mauzesor	77	3	et	et	FW
cord-256918-mauzesor	77	4	al	al	NNP
cord-256918-mauzesor	77	5	.	.	NNP
cord-256918-mauzesor	77	6	,	,	,
cord-256918-mauzesor	77	7	1995	1995	CD
cord-256918-mauzesor	77	8	;	;	:
cord-256918-mauzesor	77	9	.	.	.
cord-256918-mauzesor	78	1	Quasispecies	Quasispecies	NNP
cord-256918-mauzesor	78	2	structure	structure	NN
cord-256918-mauzesor	78	3	is	be	VBZ
cord-256918-mauzesor	78	4	an	an	DT
cord-256918-mauzesor	78	5	important	important	JJ
cord-256918-mauzesor	78	6	problem	problem	NN
cord-256918-mauzesor	78	7	for	for	IN
cord-256918-mauzesor	78	8	viral	viral	JJ
cord-256918-mauzesor	78	9	disease	disease	NN
cord-256918-mauzesor	78	10	control	control	NN
cord-256918-mauzesor	78	11	and	and	CC
cord-256918-mauzesor	78	12	should	should	MD
cord-256918-mauzesor	78	13	not	not	RB
cord-256918-mauzesor	78	14	be	be	VB
cord-256918-mauzesor	78	15	minimised	minimise	VBN
cord-256918-mauzesor	78	16	on	on	IN
cord-256918-mauzesor	78	17	account	account	NN
cord-256918-mauzesor	78	18	of	of	IN
cord-256918-mauzesor	78	19	the	the	DT
cord-256918-mauzesor	78	20	indeterminations	indetermination	NNS
cord-256918-mauzesor	78	21	found	find	VBD
cord-256918-mauzesor	78	22	when	when	WRB
cord-256918-mauzesor	78	23	trying	try	VBG
cord-256918-mauzesor	78	24	to	to	TO
cord-256918-mauzesor	78	25	define	define	VB
cord-256918-mauzesor	78	26	compositions	composition	NNS
cord-256918-mauzesor	78	27	of	of	IN
cord-256918-mauzesor	78	28	mutant	mutant	JJ
cord-256918-mauzesor	78	29	spectra	spectrum	NNS
cord-256918-mauzesor	78	30	.	.	.
cord-256918-mauzesor	79	1	The	the	DT
cord-256918-mauzesor	79	2	evolution	evolution	NN
cord-256918-mauzesor	79	3	of	of	IN
cord-256918-mauzesor	79	4	an	an	DT
cord-256918-mauzesor	79	5	RNA	RNA	NNP
cord-256918-mauzesor	79	6	virus	virus	NN
cord-256918-mauzesor	79	7	may	may	MD
cord-256918-mauzesor	79	8	be	be	VB
cord-256918-mauzesor	79	9	rapid	rapid	JJ
cord-256918-mauzesor	79	10	or	or	CC
cord-256918-mauzesor	79	11	slow	slow	JJ
cord-256918-mauzesor	79	12	,	,	,
cord-256918-mauzesor	79	13	but	but	CC
cord-256918-mauzesor	79	14	mutant	mutant	JJ
cord-256918-mauzesor	79	15	swarms	swarm	NNS
cord-256918-mauzesor	79	16	are	be	VBP
cord-256918-mauzesor	79	17	always	always	RB
cord-256918-mauzesor	79	18	hidden	hide	VBN
cord-256918-mauzesor	79	19	in	in	IN
cord-256918-mauzesor	79	20	their	-PRON-	PRP$
cord-256918-mauzesor	79	21	replicating	replicate	VBG
cord-256918-mauzesor	79	22	genome	genome	NN
cord-256918-mauzesor	79	23	populations	population	NNS
cord-256918-mauzesor	79	24	.	.	.
cord-256918-mauzesor	80	1	Research	research	NN
cord-256918-mauzesor	80	2	to	to	TO
cord-256918-mauzesor	80	3	better	better	RB
cord-256918-mauzesor	80	4	understand	understand	VB
cord-256918-mauzesor	80	5	quasispecies	quasispecie	NNS
cord-256918-mauzesor	80	6	composition	composition	NN
cord-256918-mauzesor	80	7	and	and	CC
cord-256918-mauzesor	80	8	dynamics	dynamic	NNS
cord-256918-mauzesor	80	9	is	be	VBZ
cord-256918-mauzesor	80	10	urgently	urgently	RB
cord-256918-mauzesor	80	11	needed	need	VBN
cord-256918-mauzesor	80	12	,	,	,
cord-256918-mauzesor	80	13	since	since	IN
cord-256918-mauzesor	80	14	quasispecies	quasispecie	NNS
cord-256918-mauzesor	80	15	are	be	VBP
cord-256918-mauzesor	80	16	an	an	DT
cord-256918-mauzesor	80	17	important	important	JJ
cord-256918-mauzesor	80	18	step	step	NN
cord-256918-mauzesor	80	19	in	in	IN
cord-256918-mauzesor	80	20	the	the	DT
cord-256918-mauzesor	80	21	natural	natural	JJ
cord-256918-mauzesor	80	22	history	history	NN
cord-256918-mauzesor	80	23	of	of	IN
cord-256918-mauzesor	80	24	RNA	RNA	NNP
cord-256918-mauzesor	80	25	viruses	virus	NNS
cord-256918-mauzesor	80	26	.	.	.
cord-256918-mauzesor	81	1	Crisis	crisis	NN
cord-256918-mauzesor	81	2	in	in	IN
cord-256918-mauzesor	81	3	infectious	infectious	JJ
cord-256918-mauzesor	81	4	disease	disease	NN
cord-256918-mauzesor	81	5	RNA	RNA	NNP
cord-256918-mauzesor	81	6	virus	virus	NN
cord-256918-mauzesor	81	7	evolution	evolution	NN
cord-256918-mauzesor	81	8	and	and	CC
cord-256918-mauzesor	81	9	the	the	DT
cord-256918-mauzesor	81	10	control	control	NN
cord-256918-mauzesor	81	11	of	of	IN
cord-256918-mauzesor	81	12	viral	viral	JJ
cord-256918-mauzesor	81	13	disease	disease	NN
cord-256918-mauzesor	81	14	Biological	biological	JJ
cord-256918-mauzesor	81	15	significance	significance	NN
cord-256918-mauzesor	81	16	of	of	IN
cord-256918-mauzesor	81	17	viral	viral	JJ
cord-256918-mauzesor	81	18	quasispecies	quasispecie	NNS
cord-256918-mauzesor	81	19	Complications	Complications	NNPS
cord-256918-mauzesor	81	20	of	of	IN
cord-256918-mauzesor	81	21	RNA	RNA	NNP
cord-256918-mauzesor	81	22	heterogeneity	heterogeneity	NN
cord-256918-mauzesor	81	23	for	for	IN
cord-256918-mauzesor	81	24	the	the	DT
cord-256918-mauzesor	81	25	engineering	engineering	NN
cord-256918-mauzesor	81	26	of	of	IN
cord-256918-mauzesor	81	27	virus	virus	NN
cord-256918-mauzesor	81	28	vaccines	vaccine	NNS
cord-256918-mauzesor	81	29	and	and	CC
cord-256918-mauzesor	81	30	antiviral	antiviral	JJ
cord-256918-mauzesor	81	31	agents	agent	NNS
cord-256918-mauzesor	81	32	RNA	RNA	NNP
cord-256918-mauzesor	81	33	virus	virus	NN
cord-256918-mauzesor	81	34	mutations	mutation	NNS
cord-256918-mauzesor	81	35	and	and	CC
cord-256918-mauzesor	81	36	fitness	fitness	NN
cord-256918-mauzesor	81	37	for	for	IN
cord-256918-mauzesor	81	38	survival	survival	NN
cord-256918-mauzesor	81	39	Nucleotide	nucleotide	JJ
cord-256918-mauzesor	81	40	sequence	sequence	NN
cord-256918-mauzesor	81	41	heterogeneity	heterogeneity	NN
cord-256918-mauzesor	81	42	of	of	IN
cord-256918-mauzesor	81	43	an	an	DT
cord-256918-mauzesor	81	44	RNA	RNA	NNP
cord-256918-mauzesor	81	45	phage	phage	NN
cord-256918-mauzesor	81	46	population	population	NN
cord-256918-mauzesor	81	47	Quasispecies	Quasispecies	NNPS
cord-256918-mauzesor	81	48	:	:	:
cord-256918-mauzesor	82	1	the	the	DT
cord-256918-mauzesor	82	2	concept	concept	NN
cord-256918-mauzesor	82	3	and	and	CC
cord-256918-mauzesor	82	4	the	the	DT
cord-256918-mauzesor	82	5	word	word	NN
cord-256918-mauzesor	82	6	Viral	Viral	NNP
cord-256918-mauzesor	82	7	quasispecies	quasispecie	NNS
cord-256918-mauzesor	82	8	and	and	CC
cord-256918-mauzesor	82	9	the	the	DT
cord-256918-mauzesor	82	10	problem	problem	NN
cord-256918-mauzesor	82	11	of	of	IN
cord-256918-mauzesor	82	12	vaccine	vaccine	NN
cord-256918-mauzesor	82	13	-	-	HYPH
cord-256918-mauzesor	82	14	escape	escape	NN
cord-256918-mauzesor	82	15	and	and	CC
cord-256918-mauzesor	82	16	drug	drug	NN
cord-256918-mauzesor	82	17	-	-	HYPH
cord-256918-mauzesor	82	18	resistant	resistant	JJ
cord-256918-mauzesor	82	19	mutants	mutant	NNS
cord-256918-mauzesor	82	20	RNA	RNA	NNP
cord-256918-mauzesor	82	21	virus	virus	NN
cord-256918-mauzesor	82	22	quasispecies	quasispecie	NNS
cord-256918-mauzesor	82	23	:	:	:
cord-256918-mauzesor	82	24	significance	significance	NN
cord-256918-mauzesor	82	25	for	for	IN
cord-256918-mauzesor	82	26	viral	viral	JJ
cord-256918-mauzesor	82	27	disease	disease	NN
cord-256918-mauzesor	82	28	and	and	CC
cord-256918-mauzesor	82	29	epidemiology	epidemiology	NN
cord-256918-mauzesor	82	30	Self	self	NN
cord-256918-mauzesor	82	31	-	-	HYPH
cord-256918-mauzesor	82	32	organisation	organisation	NNP
cord-256918-mauzesor	82	33	of	of	IN
cord-256918-mauzesor	82	34	matter	matter	NN
cord-256918-mauzesor	82	35	and	and	CC
cord-256918-mauzesor	82	36	the	the	DT
cord-256918-mauzesor	82	37	evolution	evolution	NN
cord-256918-mauzesor	82	38	of	of	IN
cord-256918-mauzesor	82	39	biological	biological	JJ
cord-256918-mauzesor	82	40	macromolecules	macromolecule	NNS
cord-256918-mauzesor	82	41	On	on	IN
cord-256918-mauzesor	82	42	the	the	DT
cord-256918-mauzesor	82	43	nature	nature	NN
cord-256918-mauzesor	82	44	of	of	IN
cord-256918-mauzesor	82	45	viral	viral	JJ
cord-256918-mauzesor	82	46	quasispecies	quasispecie	NNS
cord-256918-mauzesor	82	47	A	a	DT
cord-256918-mauzesor	82	48	Principle	Principle	NNP
cord-256918-mauzesor	82	49	of	of	IN
cord-256918-mauzesor	82	50	Natural	Natural	NNP
cord-256918-mauzesor	82	51	Self	Self	NNP
cord-256918-mauzesor	82	52	-	-	HYPH
cord-256918-mauzesor	82	53	Organisation	Organisation	NNP
cord-256918-mauzesor	83	1	How	how	WRB
cord-256918-mauzesor	83	2	Escherichia	escherichia	NN
cord-256918-mauzesor	83	3	coli	coli	NNS
cord-256918-mauzesor	83	4	can	can	MD
cord-256918-mauzesor	83	5	bias	bias	VB
cord-256918-mauzesor	83	6	the	the	DT
cord-256918-mauzesor	83	7	results	result	NNS
cord-256918-mauzesor	83	8	of	of	IN
cord-256918-mauzesor	83	9	molecular	molecular	JJ
cord-256918-mauzesor	83	10	cloning	cloning	NN
cord-256918-mauzesor	83	11	:	:	:
cord-256918-mauzesor	83	12	preferential	preferential	JJ
cord-256918-mauzesor	83	13	selection	selection	NN
cord-256918-mauzesor	83	14	of	of	IN
cord-256918-mauzesor	83	15	defective	defective	JJ
cord-256918-mauzesor	83	16	genomes	genome	NNS
cord-256918-mauzesor	83	17	of	of	IN
cord-256918-mauzesor	83	18	hepatitis	hepatitis	NN
cord-256918-mauzesor	83	19	C	C	NNP
cord-256918-mauzesor	83	20	virus	virus	NN
cord-256918-mauzesor	83	21	during	during	IN
cord-256918-mauzesor	83	22	the	the	DT
cord-256918-mauzesor	83	23	cloning	cloning	NN
cord-256918-mauzesor	83	24	procedure	procedure	NN
cord-256918-mauzesor	83	25	Canyon	canyon	NN
cord-256918-mauzesor	83	26	rim	rim	NN
cord-256918-mauzesor	83	27	residues	residue	NNS
cord-256918-mauzesor	83	28	,	,	,
cord-256918-mauzesor	83	29	including	include	VBG
cord-256918-mauzesor	83	30	antigenic	antigenic	JJ
cord-256918-mauzesor	83	31	determinants	determinant	NNS
cord-256918-mauzesor	83	32	,	,	,
cord-256918-mauzesor	83	33	modulate	modulate	VB
cord-256918-mauzesor	83	34	serotype	serotype	NN
cord-256918-mauzesor	83	35	-	-	HYPH
cord-256918-mauzesor	83	36	specific	specific	JJ
cord-256918-mauzesor	83	37	binding	binding	NN
cord-256918-mauzesor	83	38	of	of	IN
cord-256918-mauzesor	83	39	poliovirus	poliovirus	NN
cord-256918-mauzesor	83	40	to	to	IN
cord-256918-mauzesor	83	41	mutants	mutant	NNS
cord-256918-mauzesor	83	42	of	of	IN
cord-256918-mauzesor	83	43	the	the	DT
cord-256918-mauzesor	83	44	poliovirus	poliovirus	NN
cord-256918-mauzesor	83	45	receptor	receptor	NN
cord-256918-mauzesor	83	46	Rapid	Rapid	NNP
cord-256918-mauzesor	83	47	evolution	evolution	NN
cord-256918-mauzesor	83	48	of	of	IN
cord-256918-mauzesor	83	49	RNA	RNA	NNP
cord-256918-mauzesor	83	50	genomes	genome	NNS
cord-256918-mauzesor	83	51	RNA	RNA	NNP
cord-256918-mauzesor	83	52	virus	virus	NN
cord-256918-mauzesor	83	53	populations	population	NNS
cord-256918-mauzesor	83	54	as	as	IN
cord-256918-mauzesor	83	55	quasispecies	quasispecie	NNS
cord-256918-mauzesor	83	56	Efficient	efficient	JJ
cord-256918-mauzesor	83	57	infection	infection	NN
cord-256918-mauzesor	83	58	of	of	IN
cord-256918-mauzesor	83	59	cells	cell	NNS
cord-256918-mauzesor	83	60	in	in	IN
cord-256918-mauzesor	83	61	culture	culture	NN
cord-256918-mauzesor	83	62	by	by	IN
cord-256918-mauzesor	84	1	type	type	NN
cord-256918-mauzesor	84	2	O	O	NNP
cord-256918-mauzesor	84	3	foot	foot	NN
cord-256918-mauzesor	84	4	-	-	HYPH
cord-256918-mauzesor	84	5	and	and	CC
cord-256918-mauzesor	84	6	-	-	HYPH
cord-256918-mauzesor	84	7	mouth	mouth	NN
cord-256918-mauzesor	84	8	disease	disease	NN
cord-256918-mauzesor	84	9	virus	virus	NN
cord-256918-mauzesor	84	10	requires	require	VBZ
cord-256918-mauzesor	84	11	binding	bind	VBG
cord-256918-mauzesor	84	12	to	to	IN
cord-256918-mauzesor	84	13	cell	cell	NN
cord-256918-mauzesor	84	14	surface	surface	NN
cord-256918-mauzesor	84	15	heparan	heparan	NN
cord-256918-mauzesor	84	16	sulfate	sulfate	NN
cord-256918-mauzesor	84	17	Resistance	resistance	NN
cord-256918-mauzesor	84	18	to	to	IN
cord-256918-mauzesor	84	19	antimicrobial	antimicrobial	JJ
cord-256918-mauzesor	84	20	drugs	drug	NNS
cord-256918-mauzesor	84	21	-	-	:
cord-256918-mauzesor	84	22	a	a	DT
cord-256918-mauzesor	84	23	worldwide	worldwide	JJ
cord-256918-mauzesor	84	24	calamity	calamity	NN
cord-256918-mauzesor	84	25	Emerging	Emerging	NNP
cord-256918-mauzesor	84	26	Infections	Infections	NNPS
cord-256918-mauzesor	84	27	.	.	.
cord-256918-mauzesor	85	1	Microbial	microbial	JJ
cord-256918-mauzesor	85	2	Threats	Threats	NNPS
cord-256918-mauzesor	85	3	to	to	IN
cord-256918-mauzesor	85	4	Health	Health	NNP
cord-256918-mauzesor	85	5	in	in	IN
cord-256918-mauzesor	85	6	the	the	DT
cord-256918-mauzesor	85	7	United	United	NNP
cord-256918-mauzesor	85	8	States	States	NNP
cord-256918-mauzesor	85	9	.	.	.
cord-256918-mauzesor	86	1	Washington	Washington	NNP
cord-256918-mauzesor	86	2	Hepatitis	Hepatitis	NNP
cord-256918-mauzesor	86	3	C	C	NNP
cord-256918-mauzesor	86	4	virus	virus	NN
cord-256918-mauzesor	86	5	genome	genome	NN
cord-256918-mauzesor	86	6	complexity	complexity	NN
cord-256918-mauzesor	86	7	correlates	correlate	VBZ
cord-256918-mauzesor	86	8	with	with	IN
cord-256918-mauzesor	86	9	response	response	NN
cord-256918-mauzesor	86	10	to	to	IN
cord-256918-mauzesor	86	11	interferon	interferon	NN
cord-256918-mauzesor	86	12	therapy	therapy	NN
cord-256918-mauzesor	86	13	:	:	:
cord-256918-mauzesor	86	14	a	a	DT
cord-256918-mauzesor	86	15	study	study	NN
cord-256918-mauzesor	86	16	in	in	IN
cord-256918-mauzesor	86	17	French	french	JJ
cord-256918-mauzesor	86	18	patients	patient	NNS
cord-256918-mauzesor	86	19	with	with	IN
cord-256918-mauzesor	86	20	chronic	chronic	JJ
cord-256918-mauzesor	86	21	hepatitis	hepatitis	NN
cord-256918-mauzesor	86	22	C	c	NN
cord-256918-mauzesor	87	1	Interferon	interferon	NN
cord-256918-mauzesor	87	2	induction	induction	NN
cord-256918-mauzesor	87	3	as	as	IN
cord-256918-mauzesor	87	4	a	a	DT
cord-256918-mauzesor	87	5	quasispecies	quasispecie	NNS
cord-256918-mauzesor	87	6	marker	marker	NN
cord-256918-mauzesor	87	7	of	of	IN
cord-256918-mauzesor	88	1	vesicular	vesicular	JJ
cord-256918-mauzesor	88	2	stomatitis	stomatitis	NN
cord-256918-mauzesor	88	3	virus	virus	NN
cord-256918-mauzesor	88	4	populations	population	NNS
cord-256918-mauzesor	88	5	Evolution	evolution	NN
cord-256918-mauzesor	88	6	subverting	subvert	VBG
cord-256918-mauzesor	88	7	essentiality	essentiality	NN
cord-256918-mauzesor	88	8	:	:	:
cord-256918-mauzesor	89	1	dispensability	dispensability	NN
cord-256918-mauzesor	89	2	of	of	IN
cord-256918-mauzesor	89	3	the	the	DT
cord-256918-mauzesor	89	4	cell	cell	NN
cord-256918-mauzesor	89	5	attachment	attachment	NN
cord-256918-mauzesor	89	6	Arg	Arg	NNP
cord-256918-mauzesor	89	7	-	-	HYPH
cord-256918-mauzesor	89	8	Gly	Gly	NNP
cord-256918-mauzesor	89	9	-	-	HYPH
cord-256918-mauzesor	89	10	Asp	Asp	NNP
cord-256918-mauzesor	89	11	motif	motif	NN
cord-256918-mauzesor	89	12	in	in	IN
cord-256918-mauzesor	89	13	multiply	multiply	VB
cord-256918-mauzesor	89	14	passaged	passaged	JJ
cord-256918-mauzesor	89	15	foot	foot	NN
cord-256918-mauzesor	89	16	-	-	HYPH
cord-256918-mauzesor	89	17	and	and	CC
cord-256918-mauzesor	89	18	-	-	HYPH
cord-256918-mauzesor	89	19	mouth	mouth	NN
cord-256918-mauzesor	89	20	disease	disease	NN
cord-256918-mauzesor	89	21	virus	virus	NN
cord-256918-mauzesor	89	22	Temporal	temporal	JJ
cord-256918-mauzesor	89	23	fluctuations	fluctuation	NNS
cord-256918-mauzesor	89	24	in	in	IN
cord-256918-mauzesor	89	25	HIV	HIV	NNP
cord-256918-mauzesor	89	26	quasispecies	quasispecie	NNS
cord-256918-mauzesor	89	27	in	in	IN
cord-256918-mauzesor	89	28	vivo	vivo	NN
cord-256918-mauzesor	89	29	are	be	VBP
cord-256918-mauzesor	89	30	not	not	RB
cord-256918-mauzesor	89	31	reflected	reflect	VBN
cord-256918-mauzesor	89	32	by	by	IN
cord-256918-mauzesor	89	33	sequential	sequential	JJ
cord-256918-mauzesor	89	34	HIV	HIV	NNP
cord-256918-mauzesor	89	35	isolations	isolation	NNS
cord-256918-mauzesor	89	36	Emerging	emerge	VBG
cord-256918-mauzesor	89	37	Viruses	virus	NNS
cord-256918-mauzesor	90	1	The	the	DT
cord-256918-mauzesor	90	2	Evolutionary	Evolutionary	NNP
cord-256918-mauzesor	90	3	Biology	Biology	NNP
cord-256918-mauzesor	90	4	of	of	IN
cord-256918-mauzesor	90	5	Viruses	virus	NNS
cord-256918-mauzesor	91	1	The	the	DT
cord-256918-mauzesor	91	2	pol	pol	NN
cord-256918-mauzesor	91	3	gene	gene	NN
cord-256918-mauzesor	91	4	quasispecies	quasispecie	NNS
cord-256918-mauzesor	91	5	of	of	IN
cord-256918-mauzesor	91	6	human	human	JJ
cord-256918-mauzesor	91	7	immunodeficiency	immunodeficiency	NN
cord-256918-mauzesor	91	8	virus	virus	NN
cord-256918-mauzesor	91	9	.	.	.
cord-256918-mauzesor	92	1	Mutations	mutation	NNS
cord-256918-mauzesor	92	2	associated	associate	VBN
cord-256918-mauzesor	92	3	with	with	IN
cord-256918-mauzesor	92	4	drug	drug	NN
cord-256918-mauzesor	92	5	resistance	resistance	NN
cord-256918-mauzesor	92	6	in	in	IN
cord-256918-mauzesor	92	7	virus	virus	NN
cord-256918-mauzesor	92	8	from	from	IN
cord-256918-mauzesor	92	9	patients	patient	NNS
cord-256918-mauzesor	92	10	undergoing	undergo	VBG
cord-256918-mauzesor	92	11	no	no	DT
cord-256918-mauzesor	92	12	drug	drug	NN
cord-256918-mauzesor	92	13	therapy	therapy	NN
cord-256918-mauzesor	92	14	Rapid	rapid	JJ
cord-256918-mauzesor	92	15	viral	viral	JJ
cord-256918-mauzesor	92	16	quasispecies	quasispecie	NNS
cord-256918-mauzesor	92	17	evolution	evolution	NN
cord-256918-mauzesor	92	18	:	:	:
cord-256918-mauzesor	92	19	implications	implication	NNS
cord-256918-mauzesor	92	20	for	for	IN
cord-256918-mauzesor	92	21	vaccine	vaccine	NN
cord-256918-mauzesor	92	22	and	and	CC
cord-256918-mauzesor	92	23	drug	drug	NN
cord-256918-mauzesor	92	24	strategies	strategy	NNS
cord-256918-mauzesor	93	1	Quasispecies	Quasispecies	NNP
cord-256918-mauzesor	93	2	evolution	evolution	NN
cord-256918-mauzesor	93	3	of	of	IN
cord-256918-mauzesor	93	4	a	a	DT
cord-256918-mauzesor	93	5	hypervariable	hypervariable	JJ
cord-256918-mauzesor	93	6	region	region	NN
cord-256918-mauzesor	93	7	of	of	IN
cord-256918-mauzesor	93	8	the	the	DT
cord-256918-mauzesor	93	9	feline	feline	JJ
cord-256918-mauzesor	93	10	calicivirus	calicivirus	NNP
cord-256918-mauzesor	93	11	capsid	capsid	NN
cord-256918-mauzesor	93	12	gene	gene	NN
cord-256918-mauzesor	93	13	in	in	IN
cord-256918-mauzesor	93	14	cell	cell	NN
cord-256918-mauzesor	93	15	culture	culture	NN
cord-256918-mauzesor	93	16	and	and	CC
cord-256918-mauzesor	93	17	in	in	IN
cord-256918-mauzesor	93	18	persistently	persistently	RB
cord-256918-mauzesor	93	19	infected	infect	VBN
cord-256918-mauzesor	93	20	cats	cat	NNS
cord-256918-mauzesor	93	21	Evolution	Evolution	NNP
cord-256918-mauzesor	93	22	of	of	IN
cord-256918-mauzesor	93	23	mouse	mouse	NN
cord-256918-mauzesor	93	24	hepatitis	hepatitis	NNP
cord-256918-mauzesor	93	25	virus	virus	NN
cord-256918-mauzesor	93	26	:	:	:
cord-256918-mauzesor	93	27	detection	detection	NN
cord-256918-mauzesor	93	28	and	and	CC
cord-256918-mauzesor	93	29	characterization	characterization	NN
cord-256918-mauzesor	93	30	of	of	IN
cord-256918-mauzesor	93	31	spike	spike	NN
cord-256918-mauzesor	93	32	deletion	deletion	NN
cord-256918-mauzesor	93	33	variants	variant	NNS
cord-256918-mauzesor	93	34	during	during	IN
cord-256918-mauzesor	93	35	persistent	persistent	JJ
cord-256918-mauzesor	93	36	infection	infection	NN
cord-256918-mauzesor	93	37	Tissue	tissue	NN
cord-256918-mauzesor	93	38	culture	culture	NN
cord-256918-mauzesor	93	39	adaptation	adaptation	NN
cord-256918-mauzesor	93	40	of	of	IN
cord-256918-mauzesor	93	41	foot	foot	NN
cord-256918-mauzesor	93	42	-	-	HYPH
cord-256918-mauzesor	93	43	and	and	CC
cord-256918-mauzesor	93	44	-	-	HYPH
cord-256918-mauzesor	93	45	mouth	mouth	NN
cord-256918-mauzesor	93	46	disease	disease	NN
cord-256918-mauzesor	93	47	virus	virus	NN
cord-256918-mauzesor	93	48	selects	select	VBZ
cord-256918-mauzesor	93	49	viruses	virus	NNS
cord-256918-mauzesor	93	50	that	that	WDT
cord-256918-mauzesor	93	51	bind	bind	VBP
cord-256918-mauzesor	93	52	to	to	IN
cord-256918-mauzesor	93	53	heparin	heparin	NN
cord-256918-mauzesor	93	54	and	and	CC
cord-256918-mauzesor	93	55	are	be	VBP
cord-256918-mauzesor	93	56	attenuated	attenuate	VBN
cord-256918-mauzesor	93	57	in	in	IN
cord-256918-mauzesor	93	58	cattle	cattle	NNS
cord-256918-mauzesor	93	59	Structural	structural	JJ
cord-256918-mauzesor	93	60	and	and	CC
cord-256918-mauzesor	93	61	mechanistic	mechanistic	JJ
cord-256918-mauzesor	93	62	relationships	relationship	NNS
cord-256918-mauzesor	93	63	between	between	IN
cord-256918-mauzesor	93	64	nucleic	nucleic	JJ
cord-256918-mauzesor	93	65	acid	acid	NN
cord-256918-mauzesor	93	66	polymerases	polymerase	NNS
cord-256918-mauzesor	93	67	Lack	lack	VBP
cord-256918-mauzesor	93	68	of	of	IN
cord-256918-mauzesor	93	69	evidence	evidence	NN
cord-256918-mauzesor	93	70	for	for	IN
cord-256918-mauzesor	93	71	proofreading	proofread	VBG
cord-256918-mauzesor	93	72	mechanisms	mechanism	NNS
cord-256918-mauzesor	93	73	associated	associate	VBN
cord-256918-mauzesor	93	74	with	with	IN
cord-256918-mauzesor	93	75	an	an	DT
cord-256918-mauzesor	93	76	RNA	RNA	NNP
cord-256918-mauzesor	93	77	virus	virus	NN
cord-256918-mauzesor	93	78	polymerase	polymerase	NN
cord-256918-mauzesor	93	79	From	from	IN
cord-256918-mauzesor	93	80	the	the	DT
cord-256918-mauzesor	93	81	double	double	JJ
cord-256918-mauzesor	93	82	-	-	HYPH
cord-256918-mauzesor	93	83	helix	helix	NN
cord-256918-mauzesor	93	84	to	to	IN
cord-256918-mauzesor	93	85	novel	novel	JJ
cord-256918-mauzesor	93	86	approaches	approach	NNS
cord-256918-mauzesor	93	87	to	to	IN
cord-256918-mauzesor	93	88	the	the	DT
cord-256918-mauzesor	93	89	sequencing	sequencing	NN
cord-256918-mauzesor	93	90	of	of	IN
cord-256918-mauzesor	93	91	large	large	JJ
cord-256918-mauzesor	93	92	genomes	genome	NNS
cord-256918-mauzesor	93	93	The	the	DT
cord-256918-mauzesor	93	94	author	author	NN
cord-256918-mauzesor	93	95	is	be	VBZ
cord-256918-mauzesor	93	96	indebted	indebte	VBN
cord-256918-mauzesor	93	97	to	to	IN
cord-256918-mauzesor	93	98	John	John	NNP
cord-256918-mauzesor	93	99	Holland	Holland	NNP
cord-256918-mauzesor	93	100	and	and	CC
cord-256918-mauzesor	93	101	his	-PRON-	PRP$
cord-256918-mauzesor	93	102	colleagues	colleague	NNS
cord-256918-mauzesor	93	103	for	for	IN
cord-256918-mauzesor	93	104	many	many	JJ
cord-256918-mauzesor	93	105	years	year	NNS
cord-256918-mauzesor	93	106	of	of	IN
cord-256918-mauzesor	93	107	collaboration	collaboration	NN
cord-256918-mauzesor	93	108	and	and	CC
cord-256918-mauzesor	93	109	helpful	helpful	JJ
cord-256918-mauzesor	93	110	discussions	discussion	NNS
cord-256918-mauzesor	93	111	,	,	,
cord-256918-mauzesor	93	112	and	and	CC
cord-256918-mauzesor	93	113	to	to	TO
cord-256918-mauzesor	93	114	may	may	MD
cord-256918-mauzesor	93	115	colleagues	colleague	NNS
cord-256918-mauzesor	93	116	and	and	CC
cord-256918-mauzesor	93	117	students	student	NNS
cord-256918-mauzesor	93	118	from	from	IN
cord-256918-mauzesor	93	119	the	the	DT
cord-256918-mauzesor	93	120	laboratory	laboratory	NN
cord-256918-mauzesor	93	121	for	for	IN
cord-256918-mauzesor	93	122	contributions	contribution	NNS
cord-256918-mauzesor	93	123	to	to	IN
cord-256918-mauzesor	93	124	RNA	RNA	NNP
cord-256918-mauzesor	93	125	virus	virus	NN
cord-256918-mauzesor	93	126	quasispecies	quasispecie	NNS
cord-256918-mauzesor	93	127	.	.	.
cord-256918-mauzesor	94	1	This	this	DT
cord-256918-mauzesor	94	2	work	work	NN
cord-256918-mauzesor	94	3	was	be	VBD
cord-256918-mauzesor	94	4	supported	support	VBN
cord-256918-mauzesor	94	5	by	by	IN
cord-256918-mauzesor	94	6	grant	grant	NN
cord-256918-mauzesor	94	7	DGICYT	DGICYT	NNP
cord-256918-mauzesor	94	8	PB94	PB94	NNP
cord-256918-mauzesor	94	9	-	-	HYPH
cord-256918-mauzesor	94	10	0034-C02	0034-C02	NNP
cord-256918-mauzesor	94	11	-	-	HYPH
cord-256918-mauzesor	94	12	01	01	CD
cord-256918-mauzesor	94	13	,	,	,
cord-256918-mauzesor	94	14	FIS	FIS	NNP
cord-256918-mauzesor	94	15	95/	95/	CD
cord-256918-mauzesor	94	16	0034	0034	CD
cord-256918-mauzesor	94	17	-	-	SYM
cord-256918-mauzesor	94	18	1	1	CD
cord-256918-mauzesor	94	19	,	,	,
cord-256918-mauzesor	94	20	FIS	FIS	NNP
cord-256918-mauzesor	94	21	98/0054	98/0054	CD
cord-256918-mauzesor	94	22	-	-	HYPH
cord-256918-mauzesor	94	23	00	00	CD
cord-256918-mauzesor	94	24	,	,	,
cord-256918-mauzesor	94	25	and	and	CC
cord-256918-mauzesor	94	26	Fundació	Fundació	NNP
cord-256918-mauzesor	94	27	n	n	NNP
cord-256918-mauzesor	94	28	Ramón	Ramón	NNP
cord-256918-mauzesor	94	29	Areces	Areces	NNP
cord-256918-mauzesor	94	30	.	.	.