id	sid	tid	token	lemma	pos
cord-022290-p0l1kv6n	1	1	key	key	JJ
cord-022290-p0l1kv6n	1	2	:	:	:
cord-022290-p0l1kv6n	1	3	cord-022290-p0l1kv6n	cord-022290-p0l1kv6n	CD
cord-022290-p0l1kv6n	1	4	authors	author	NNS
cord-022290-p0l1kv6n	1	5	:	:	:
cord-022290-p0l1kv6n	1	6	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	1	7	,	,	,
cord-022290-p0l1kv6n	1	8	Ernst	Ernst	NNP
cord-022290-p0l1kv6n	1	9	M.	M.	NNP
cord-022290-p0l1kv6n	1	10	;	;	:
cord-022290-p0l1kv6n	1	11	James	James	NNP
cord-022290-p0l1kv6n	1	12	,	,	,
cord-022290-p0l1kv6n	1	13	Michael	Michael	NNP
cord-022290-p0l1kv6n	1	14	N.G.	N.G.	NNP
cord-022290-p0l1kv6n	1	15	title	title	NN
cord-022290-p0l1kv6n	1	16	:	:	:
cord-022290-p0l1kv6n	1	17	Proteolytic	Proteolytic	NNP
cord-022290-p0l1kv6n	1	18	Enzymes	enzyme	NNS
cord-022290-p0l1kv6n	1	19	of	of	IN
cord-022290-p0l1kv6n	1	20	the	the	DT
cord-022290-p0l1kv6n	1	21	Viruses	virus	NNS
cord-022290-p0l1kv6n	1	22	of	of	IN
cord-022290-p0l1kv6n	1	23	the	the	DT
cord-022290-p0l1kv6n	1	24	Family	Family	NNP
cord-022290-p0l1kv6n	1	25	Picornaviridae	Picornaviridae	NNP
cord-022290-p0l1kv6n	1	26	date	date	NN
cord-022290-p0l1kv6n	1	27	:	:	:
cord-022290-p0l1kv6n	1	28	2007	2007	CD
cord-022290-p0l1kv6n	1	29	-	-	SYM
cord-022290-p0l1kv6n	1	30	05	05	CD
cord-022290-p0l1kv6n	1	31	-	-	HYPH
cord-022290-p0l1kv6n	1	32	09	09	CD
cord-022290-p0l1kv6n	1	33	journal	journal	NN
cord-022290-p0l1kv6n	1	34	:	:	:
cord-022290-p0l1kv6n	1	35	Proteases	Proteases	NNP
cord-022290-p0l1kv6n	1	36	of	of	IN
cord-022290-p0l1kv6n	1	37	Infectious	Infectious	NNP
cord-022290-p0l1kv6n	1	38	Agents	Agents	NNPS
cord-022290-p0l1kv6n	1	39	DOI	DOI	NNP
cord-022290-p0l1kv6n	1	40	:	:	:
cord-022290-p0l1kv6n	1	41	10.1016/	10.1016/	CD
cord-022290-p0l1kv6n	2	1	b978	b978	NNP
cord-022290-p0l1kv6n	2	2	-	-	HYPH
cord-022290-p0l1kv6n	2	3	012420510	012420510	CD
cord-022290-p0l1kv6n	2	4	-	-	HYPH
cord-022290-p0l1kv6n	2	5	9/50032	9/50032	CD
cord-022290-p0l1kv6n	2	6	-	-	SYM
cord-022290-p0l1kv6n	2	7	6	6	CD
cord-022290-p0l1kv6n	2	8	sha	sha	NNP
cord-022290-p0l1kv6n	2	9	:	:	:
cord-022290-p0l1kv6n	2	10	fdc764454f86802bd10b0e4eeb71ef5960a2fec0	fdc764454f86802bd10b0e4eeb71ef5960a2fec0	NFP
cord-022290-p0l1kv6n	2	11	doc_id	doc_id	CD
cord-022290-p0l1kv6n	2	12	:	:	:
cord-022290-p0l1kv6n	2	13	22290	22290	CD
cord-022290-p0l1kv6n	2	14	cord_uid	cord_uid	NNS
cord-022290-p0l1kv6n	2	15	:	:	:
cord-022290-p0l1kv6n	2	16	p0l1kv6n	p0l1kv6n	NN
cord-022290-p0l1kv6n	3	1	This	this	DT
cord-022290-p0l1kv6n	3	2	chapter	chapter	NN
cord-022290-p0l1kv6n	3	3	deals	deal	VBZ
cord-022290-p0l1kv6n	3	4	with	with	IN
cord-022290-p0l1kv6n	3	5	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	3	6	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	3	7	of	of	IN
cord-022290-p0l1kv6n	3	8	the	the	DT
cord-022290-p0l1kv6n	3	9	viruses	virus	NNS
cord-022290-p0l1kv6n	3	10	of	of	IN
cord-022290-p0l1kv6n	3	11	the	the	DT
cord-022290-p0l1kv6n	3	12	family	family	NN
cord-022290-p0l1kv6n	3	13	picornaviridae	picornaviridae	NN
cord-022290-p0l1kv6n	3	14	.	.	.
cord-022290-p0l1kv6n	4	1	The	the	DT
cord-022290-p0l1kv6n	4	2	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	4	3	3C	3C	NNP
cord-022290-p0l1kv6n	4	4	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	4	5	constitute	constitute	VBP
cord-022290-p0l1kv6n	4	6	an	an	DT
cord-022290-p0l1kv6n	4	7	ideal	ideal	JJ
cord-022290-p0l1kv6n	4	8	target	target	NN
cord-022290-p0l1kv6n	4	9	for	for	IN
cord-022290-p0l1kv6n	4	10	the	the	DT
cord-022290-p0l1kv6n	4	11	rational	rational	JJ
cord-022290-p0l1kv6n	4	12	design	design	NN
cord-022290-p0l1kv6n	4	13	of	of	IN
cord-022290-p0l1kv6n	4	14	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	4	15	drugs	drug	NNS
cord-022290-p0l1kv6n	4	16	.	.	.
cord-022290-p0l1kv6n	5	1	The	the	DT
cord-022290-p0l1kv6n	5	2	chapter	chapter	NN
cord-022290-p0l1kv6n	5	3	discusses	discuss	VBZ
cord-022290-p0l1kv6n	5	4	the	the	DT
cord-022290-p0l1kv6n	5	5	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	5	6	-	-	HYPH
cord-022290-p0l1kv6n	5	7	like	like	JJ
cord-022290-p0l1kv6n	5	8	cysteine	cysteine	NN
cord-022290-p0l1kv6n	5	9	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	5	10	,	,	,
cord-022290-p0l1kv6n	5	11	which	which	WDT
cord-022290-p0l1kv6n	5	12	constitute	constitute	VBP
cord-022290-p0l1kv6n	5	13	a	a	DT
cord-022290-p0l1kv6n	5	14	unique	unique	JJ
cord-022290-p0l1kv6n	5	15	class	class	NN
cord-022290-p0l1kv6n	5	16	of	of	IN
cord-022290-p0l1kv6n	5	17	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	5	18	with	with	IN
cord-022290-p0l1kv6n	5	19	a	a	DT
cord-022290-p0l1kv6n	5	20	distinct	distinct	JJ
cord-022290-p0l1kv6n	5	21	substrate	substrate	NN
cord-022290-p0l1kv6n	5	22	specificity	specificity	NN
cord-022290-p0l1kv6n	5	23	,	,	,
cord-022290-p0l1kv6n	5	24	and	and	CC
cord-022290-p0l1kv6n	5	25	are	be	VBP
cord-022290-p0l1kv6n	5	26	so	so	RB
cord-022290-p0l1kv6n	5	27	far	far	RB
cord-022290-p0l1kv6n	5	28	only	only	RB
cord-022290-p0l1kv6n	5	29	found	find	VBN
cord-022290-p0l1kv6n	5	30	in	in	IN
cord-022290-p0l1kv6n	5	31	+	+	CC
cord-022290-p0l1kv6n	5	32	RNA	RNA	NNP
cord-022290-p0l1kv6n	5	33	viruses	virus	NNS
cord-022290-p0l1kv6n	5	34	.	.	.
cord-022290-p0l1kv6n	6	1	Within	within	IN
cord-022290-p0l1kv6n	6	2	these	these	DT
cord-022290-p0l1kv6n	6	3	viruses	virus	NNS
cord-022290-p0l1kv6n	6	4	the	the	DT
cord-022290-p0l1kv6n	6	5	3C	3C	NNP
cord-022290-p0l1kv6n	6	6	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	6	7	perform	perform	VBP
cord-022290-p0l1kv6n	6	8	a	a	DT
cord-022290-p0l1kv6n	6	9	central	central	JJ
cord-022290-p0l1kv6n	6	10	and	and	CC
cord-022290-p0l1kv6n	6	11	indispensable	indispensable	JJ
cord-022290-p0l1kv6n	6	12	role	role	NN
cord-022290-p0l1kv6n	6	13	during	during	IN
cord-022290-p0l1kv6n	6	14	the	the	DT
cord-022290-p0l1kv6n	6	15	viral	viral	JJ
cord-022290-p0l1kv6n	6	16	life	life	NN
cord-022290-p0l1kv6n	6	17	cycle	cycle	NN
cord-022290-p0l1kv6n	6	18	and	and	CC
cord-022290-p0l1kv6n	6	19	3C	3c	NN
cord-022290-p0l1kv6n	6	20	proteinase	proteinase	NN
cord-022290-p0l1kv6n	6	21	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	7	1	have	have	VB
cord-022290-p0l1kv6n	7	2	the	the	DT
cord-022290-p0l1kv6n	7	3	potential	potential	NN
cord-022290-p0l1kv6n	7	4	to	to	TO
cord-022290-p0l1kv6n	7	5	limit	limit	VB
cord-022290-p0l1kv6n	7	6	the	the	DT
cord-022290-p0l1kv6n	7	7	spread	spread	NN
cord-022290-p0l1kv6n	7	8	of	of	IN
cord-022290-p0l1kv6n	7	9	viral	viral	JJ
cord-022290-p0l1kv6n	7	10	infections	infection	NNS
cord-022290-p0l1kv6n	7	11	.	.	.
cord-022290-p0l1kv6n	8	1	The	the	DT
cord-022290-p0l1kv6n	8	2	chapter	chapter	NN
cord-022290-p0l1kv6n	8	3	concludes	conclude	VBZ
cord-022290-p0l1kv6n	8	4	that	that	IN
cord-022290-p0l1kv6n	8	5	there	there	EX
cord-022290-p0l1kv6n	8	6	is	be	VBZ
cord-022290-p0l1kv6n	8	7	a	a	DT
cord-022290-p0l1kv6n	8	8	wealth	wealth	NN
cord-022290-p0l1kv6n	8	9	of	of	IN
cord-022290-p0l1kv6n	8	10	experimental	experimental	JJ
cord-022290-p0l1kv6n	8	11	information	information	NN
cord-022290-p0l1kv6n	8	12	available	available	JJ
cord-022290-p0l1kv6n	8	13	for	for	IN
cord-022290-p0l1kv6n	8	14	the	the	DT
cord-022290-p0l1kv6n	8	15	best	well	RBS
cord-022290-p0l1kv6n	8	16	-	-	HYPH
cord-022290-p0l1kv6n	8	17	studied	study	VBN
cord-022290-p0l1kv6n	8	18	examples	example	NNS
cord-022290-p0l1kv6n	8	19	of	of	IN
cord-022290-p0l1kv6n	8	20	the	the	DT
cord-022290-p0l1kv6n	8	21	viruses	virus	NNS
cord-022290-p0l1kv6n	8	22	of	of	IN
cord-022290-p0l1kv6n	8	23	the	the	DT
cord-022290-p0l1kv6n	8	24	Picornaviridae	Picornaviridae	NNP
cord-022290-p0l1kv6n	8	25	.	.	.
cord-022290-p0l1kv6n	9	1	This	this	DT
cord-022290-p0l1kv6n	9	2	information	information	NN
cord-022290-p0l1kv6n	9	3	provides	provide	VBZ
cord-022290-p0l1kv6n	9	4	an	an	DT
cord-022290-p0l1kv6n	9	5	opportunity	opportunity	NN
cord-022290-p0l1kv6n	9	6	to	to	TO
cord-022290-p0l1kv6n	9	7	design	design	VB
cord-022290-p0l1kv6n	9	8	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	9	9	against	against	IN
cord-022290-p0l1kv6n	9	10	the	the	DT
cord-022290-p0l1kv6n	9	11	viral	viral	JJ
cord-022290-p0l1kv6n	9	12	3C	3C	NNP
cord-022290-p0l1kv6n	9	13	proteinase	proteinase	NN
cord-022290-p0l1kv6n	9	14	.	.	.
cord-022290-p0l1kv6n	10	1	Effective	effective	JJ
cord-022290-p0l1kv6n	10	2	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	10	3	of	of	IN
cord-022290-p0l1kv6n	10	4	the	the	DT
cord-022290-p0l1kv6n	10	5	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	11	1	3C	3C	NNP
cord-022290-p0l1kv6n	11	2	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	11	3	have	have	VBP
cord-022290-p0l1kv6n	11	4	the	the	DT
cord-022290-p0l1kv6n	11	5	potential	potential	NN
cord-022290-p0l1kv6n	11	6	to	to	TO
cord-022290-p0l1kv6n	11	7	become	become	VB
cord-022290-p0l1kv6n	11	8	effective	effective	JJ
cord-022290-p0l1kv6n	11	9	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	11	10	drugs	drug	NNS
cord-022290-p0l1kv6n	11	11	against	against	IN
cord-022290-p0l1kv6n	11	12	human	human	JJ
cord-022290-p0l1kv6n	11	13	diseases	disease	NNS
cord-022290-p0l1kv6n	11	14	such	such	JJ
cord-022290-p0l1kv6n	11	15	as	as	IN
cord-022290-p0l1kv6n	11	16	the	the	DT
cord-022290-p0l1kv6n	11	17	common	common	JJ
cord-022290-p0l1kv6n	11	18	cold	cold	NN
cord-022290-p0l1kv6n	11	19	,	,	,
cord-022290-p0l1kv6n	11	20	HAV	HAV	NNP
cord-022290-p0l1kv6n	11	21	,	,	,
cord-022290-p0l1kv6n	11	22	enteroviral	enteroviral	JJ
cord-022290-p0l1kv6n	11	23	infections	infection	NNS
cord-022290-p0l1kv6n	11	24	,	,	,
cord-022290-p0l1kv6n	11	25	and	and	CC
cord-022290-p0l1kv6n	11	26	diseases	disease	NNS
cord-022290-p0l1kv6n	11	27	caused	cause	VBN
cord-022290-p0l1kv6n	11	28	by	by	IN
cord-022290-p0l1kv6n	11	29	related	relate	VBN
cord-022290-p0l1kv6n	11	30	+	+	CC
cord-022290-p0l1kv6n	11	31	RNA	RNA	NNP
cord-022290-p0l1kv6n	11	32	viruses	virus	NNS
cord-022290-p0l1kv6n	11	33	.	.	.
cord-022290-p0l1kv6n	12	1	Picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	12	2	cause	cause	VBP
cord-022290-p0l1kv6n	12	3	a	a	DT
cord-022290-p0l1kv6n	12	4	wide	wide	JJ
cord-022290-p0l1kv6n	12	5	variety	variety	NN
cord-022290-p0l1kv6n	12	6	of	of	IN
cord-022290-p0l1kv6n	12	7	diseases	disease	NNS
cord-022290-p0l1kv6n	12	8	in	in	IN
cord-022290-p0l1kv6n	12	9	humans	human	NNS
cord-022290-p0l1kv6n	12	10	and	and	CC
cord-022290-p0l1kv6n	12	11	animals	animal	NNS
cord-022290-p0l1kv6n	12	12	(	(	-LRB-
cord-022290-p0l1kv6n	12	13	Couch	couch	NN
cord-022290-p0l1kv6n	12	14	,	,	,
cord-022290-p0l1kv6n	12	15	1996	1996	CD
cord-022290-p0l1kv6n	12	16	;	;	:
cord-022290-p0l1kv6n	12	17	Hollinger	Hollinger	NNP
cord-022290-p0l1kv6n	12	18	and	and	CC
cord-022290-p0l1kv6n	12	19	Ticehurst	Ticehurst	NNP
cord-022290-p0l1kv6n	12	20	,	,	,
cord-022290-p0l1kv6n	12	21	1996	1996	CD
cord-022290-p0l1kv6n	12	22	;	;	:
cord-022290-p0l1kv6n	12	23	Melnik	Melnik	NNP
cord-022290-p0l1kv6n	12	24	,	,	,
cord-022290-p0l1kv6n	12	25	1996	1996	CD
cord-022290-p0l1kv6n	12	26	)	)	-RRB-
cord-022290-p0l1kv6n	12	27	.	.	.
cord-022290-p0l1kv6n	13	1	These	these	DT
cord-022290-p0l1kv6n	13	2	range	range	VBP
cord-022290-p0l1kv6n	13	3	from	from	IN
cord-022290-p0l1kv6n	13	4	relatively	relatively	RB
cord-022290-p0l1kv6n	13	5	mild	mild	JJ
cord-022290-p0l1kv6n	13	6	and	and	CC
cord-022290-p0l1kv6n	13	7	widespread	widespread	JJ
cord-022290-p0l1kv6n	13	8	infections	infection	NNS
cord-022290-p0l1kv6n	13	9	,	,	,
cord-022290-p0l1kv6n	13	10	such	such	JJ
cord-022290-p0l1kv6n	13	11	as	as	IN
cord-022290-p0l1kv6n	13	12	the	the	DT
cord-022290-p0l1kv6n	13	13	common	common	JJ
cord-022290-p0l1kv6n	13	14	cold	cold	NN
cord-022290-p0l1kv6n	13	15	and	and	CC
cord-022290-p0l1kv6n	13	16	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	13	17	A	A	NNP
cord-022290-p0l1kv6n	13	18	,	,	,
cord-022290-p0l1kv6n	13	19	to	to	TO
cord-022290-p0l1kv6n	13	20	rare	rare	JJ
cord-022290-p0l1kv6n	13	21	but	but	CC
cord-022290-p0l1kv6n	13	22	often	often	RB
cord-022290-p0l1kv6n	13	23	severe	severe	JJ
cord-022290-p0l1kv6n	13	24	enteroviral	enteroviral	JJ
cord-022290-p0l1kv6n	13	25	diseases	disease	NNS
cord-022290-p0l1kv6n	13	26	(	(	-LRB-
cord-022290-p0l1kv6n	13	27	Table	table	NN
cord-022290-p0l1kv6n	13	28	I	i	CD
cord-022290-p0l1kv6n	13	29	)	)	-RRB-
cord-022290-p0l1kv6n	13	30	.	.	.
cord-022290-p0l1kv6n	14	1	There	there	EX
cord-022290-p0l1kv6n	14	2	is	be	VBZ
cord-022290-p0l1kv6n	14	3	some	some	DT
cord-022290-p0l1kv6n	14	4	evidence	evidence	NN
cord-022290-p0l1kv6n	14	5	that	that	IN
cord-022290-p0l1kv6n	14	6	Picornavirus	Picornavirus	NNP
cord-022290-p0l1kv6n	14	7	infections	infection	NNS
cord-022290-p0l1kv6n	14	8	are	be	VBP
cord-022290-p0l1kv6n	14	9	also	also	RB
cord-022290-p0l1kv6n	14	10	involved	involve	VBN
cord-022290-p0l1kv6n	14	11	in	in	IN
cord-022290-p0l1kv6n	14	12	the	the	DT
cord-022290-p0l1kv6n	14	13	onset	onset	NN
cord-022290-p0l1kv6n	14	14	of	of	IN
cord-022290-p0l1kv6n	14	15	severe	severe	JJ
cord-022290-p0l1kv6n	14	16	autoimmune	autoimmune	JJ
cord-022290-p0l1kv6n	14	17	diseases	disease	NNS
cord-022290-p0l1kv6n	14	18	such	such	JJ
cord-022290-p0l1kv6n	14	19	as	as	IN
cord-022290-p0l1kv6n	14	20	myocarditis	myocarditis	NN
cord-022290-p0l1kv6n	14	21	,	,	,
cord-022290-p0l1kv6n	14	22	diabetes	diabetes	NN
cord-022290-p0l1kv6n	14	23	,	,	,
cord-022290-p0l1kv6n	14	24	and	and	CC
cord-022290-p0l1kv6n	14	25	multiple	multiple	JJ
cord-022290-p0l1kv6n	14	26	sclerosis	sclerosis	NN
cord-022290-p0l1kv6n	14	27	(	(	-LRB-
cord-022290-p0l1kv6n	15	1	Carthy	Carthy	NNP
cord-022290-p0l1kv6n	15	2	et	et	FW
cord-022290-p0l1kv6n	15	3	al	al	NNP
cord-022290-p0l1kv6n	15	4	.	.	NNP
cord-022290-p0l1kv6n	15	5	,	,	,
cord-022290-p0l1kv6n	15	6	1997	1997	CD
cord-022290-p0l1kv6n	15	7	;	;	:
cord-022290-p0l1kv6n	15	8	Steinmann	Steinmann	NNP
cord-022290-p0l1kv6n	15	9	and	and	CC
cord-022290-p0l1kv6n	15	10	Conlon	Conlon	NNP
cord-022290-p0l1kv6n	15	11	,	,	,
cord-022290-p0l1kv6n	15	12	1997	1997	CD
cord-022290-p0l1kv6n	15	13	)	)	-RRB-
cord-022290-p0l1kv6n	15	14	.	.	.
cord-022290-p0l1kv6n	16	1	Recently	recently	RB
cord-022290-p0l1kv6n	16	2	a	a	DT
cord-022290-p0l1kv6n	16	3	mouse	mouse	NN
cord-022290-p0l1kv6n	16	4	model	model	NN
cord-022290-p0l1kv6n	16	5	for	for	IN
cord-022290-p0l1kv6n	16	6	a	a	DT
cord-022290-p0l1kv6n	16	7	demyelinating	demyelinating	JJ
cord-022290-p0l1kv6n	16	8	disease	disease	NN
cord-022290-p0l1kv6n	16	9	that	that	WDT
cord-022290-p0l1kv6n	16	10	resembles	resemble	VBZ
cord-022290-p0l1kv6n	16	11	multiple	multiple	JJ
cord-022290-p0l1kv6n	16	12	sclerosis	sclerosis	NN
cord-022290-p0l1kv6n	16	13	,	,	,
cord-022290-p0l1kv6n	16	14	provided	provide	VBD
cord-022290-p0l1kv6n	16	15	a	a	DT
cord-022290-p0l1kv6n	16	16	plausible	plausible	JJ
cord-022290-p0l1kv6n	16	17	,	,	,
cord-022290-p0l1kv6n	16	18	immunological	immunological	JJ
cord-022290-p0l1kv6n	16	19	mechanism	mechanism	NN
cord-022290-p0l1kv6n	16	20	for	for	IN
cord-022290-p0l1kv6n	16	21	the	the	DT
cord-022290-p0l1kv6n	16	22	triggering	triggering	NN
cord-022290-p0l1kv6n	16	23	of	of	IN
cord-022290-p0l1kv6n	16	24	such	such	JJ
cord-022290-p0l1kv6n	16	25	diseases	disease	NNS
cord-022290-p0l1kv6n	16	26	by	by	IN
cord-022290-p0l1kv6n	16	27	a	a	DT
cord-022290-p0l1kv6n	16	28	viral	viral	JJ
cord-022290-p0l1kv6n	16	29	infection	infection	NN
cord-022290-p0l1kv6n	16	30	(	(	-LRB-
cord-022290-p0l1kv6n	16	31	Miller	Miller	NNP
cord-022290-p0l1kv6n	16	32	et	et	NNP
cord-022290-p0l1kv6n	16	33	al	al	NNP
cord-022290-p0l1kv6n	16	34	.	.	NNP
cord-022290-p0l1kv6n	16	35	,	,	,
cord-022290-p0l1kv6n	16	36	1997	1997	CD
cord-022290-p0l1kv6n	16	37	)	)	-RRB-
cord-022290-p0l1kv6n	16	38	.	.	.
cord-022290-p0l1kv6n	17	1	The	the	DT
cord-022290-p0l1kv6n	17	2	Picornaviruses	Picornaviruses	NNP
cord-022290-p0l1kv6n	17	3	release	release	VBP
cord-022290-p0l1kv6n	17	4	their	-PRON-	PRP$
cord-022290-p0l1kv6n	17	5	single	single	JJ
cord-022290-p0l1kv6n	17	6	-	-	HYPH
cord-022290-p0l1kv6n	17	7	stranded	stranded	JJ
cord-022290-p0l1kv6n	17	8	,	,	,
cord-022290-p0l1kv6n	17	9	mRNA	mrna	NN
cord-022290-p0l1kv6n	17	10	-	-	HYPH
cord-022290-p0l1kv6n	17	11	like	like	JJ
cord-022290-p0l1kv6n	17	12	genome	genome	NN
cord-022290-p0l1kv6n	17	13	into	into	IN
cord-022290-p0l1kv6n	17	14	the	the	DT
cord-022290-p0l1kv6n	17	15	cytosol	cytosol	NN
cord-022290-p0l1kv6n	17	16	of	of	IN
cord-022290-p0l1kv6n	17	17	the	the	DT
cord-022290-p0l1kv6n	17	18	host	host	NN
cord-022290-p0l1kv6n	17	19	cell	cell	NN
cord-022290-p0l1kv6n	17	20	where	where	WRB
cord-022290-p0l1kv6n	17	21	it	-PRON-	PRP
cord-022290-p0l1kv6n	17	22	is	be	VBZ
cord-022290-p0l1kv6n	17	23	translated	translate	VBN
cord-022290-p0l1kv6n	17	24	into	into	IN
cord-022290-p0l1kv6n	17	25	large	large	JJ
cord-022290-p0l1kv6n	17	26	polyproteins	polyprotein	NNS
cord-022290-p0l1kv6n	17	27	.	.	.
cord-022290-p0l1kv6n	18	1	The	the	DT
cord-022290-p0l1kv6n	18	2	resulting	result	VBG
cord-022290-p0l1kv6n	18	3	polyproteins	polyprotein	NNS
cord-022290-p0l1kv6n	18	4	are	be	VBP
cord-022290-p0l1kv6n	18	5	then	then	RB
cord-022290-p0l1kv6n	18	6	cleaved	cleave	VBN
cord-022290-p0l1kv6n	18	7	by	by	IN
cord-022290-p0l1kv6n	18	8	specific	specific	JJ
cord-022290-p0l1kv6n	18	9	viral	viral	JJ
cord-022290-p0l1kv6n	18	10	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	18	11	into	into	IN
cord-022290-p0l1kv6n	18	12	the	the	DT
cord-022290-p0l1kv6n	18	13	structural	structural	JJ
cord-022290-p0l1kv6n	18	14	and	and	CC
cord-022290-p0l1kv6n	18	15	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	18	16	proteins	protein	NNS
cord-022290-p0l1kv6n	18	17	of	of	IN
cord-022290-p0l1kv6n	18	18	the	the	DT
cord-022290-p0l1kv6n	18	19	virus	virus	NN
cord-022290-p0l1kv6n	19	1	(	(	-LRB-
cord-022290-p0l1kv6n	19	2	Kr	Kr	NNP
cord-022290-p0l1kv6n	19	3	~	~	NNP
cord-022290-p0l1kv6n	19	4	iusslich	iusslich	NNP
cord-022290-p0l1kv6n	19	5	and	and	CC
cord-022290-p0l1kv6n	19	6	.	.	.
cord-022290-p0l1kv6n	20	1	Figure	figure	NN
cord-022290-p0l1kv6n	20	2	1	1	CD
cord-022290-p0l1kv6n	20	3	shows	show	VBZ
cord-022290-p0l1kv6n	20	4	a	a	DT
cord-022290-p0l1kv6n	20	5	simplified	simplified	JJ
cord-022290-p0l1kv6n	20	6	scheme	scheme	NN
cord-022290-p0l1kv6n	20	7	of	of	IN
cord-022290-p0l1kv6n	20	8	the	the	DT
cord-022290-p0l1kv6n	20	9	life	life	NN
cord-022290-p0l1kv6n	20	10	cycle	cycle	NN
cord-022290-p0l1kv6n	20	11	of	of	IN
cord-022290-p0l1kv6n	20	12	a	a	DT
cord-022290-p0l1kv6n	20	13	typical	typical	JJ
cord-022290-p0l1kv6n	20	14	Picornavirus	Picornavirus	NNP
cord-022290-p0l1kv6n	20	15	.	.	.
cord-022290-p0l1kv6n	21	1	The	the	DT
cord-022290-p0l1kv6n	21	2	virus	virus	NN
cord-022290-p0l1kv6n	21	3	binds	bind	VBZ
cord-022290-p0l1kv6n	21	4	to	to	IN
cord-022290-p0l1kv6n	21	5	a	a	DT
cord-022290-p0l1kv6n	21	6	specific	specific	JJ
cord-022290-p0l1kv6n	21	7	receptor	receptor	NN
cord-022290-p0l1kv6n	21	8	on	on	IN
cord-022290-p0l1kv6n	21	9	the	the	DT
cord-022290-p0l1kv6n	21	10	cell	cell	NN
cord-022290-p0l1kv6n	21	11	surface	surface	NN
cord-022290-p0l1kv6n	21	12	.	.	.
cord-022290-p0l1kv6n	22	1	The	the	DT
cord-022290-p0l1kv6n	22	2	specific	specific	JJ
cord-022290-p0l1kv6n	22	3	receptors	receptor	NNS
cord-022290-p0l1kv6n	22	4	are	be	VBP
cord-022290-p0l1kv6n	22	5	different	different	JJ
cord-022290-p0l1kv6n	22	6	for	for	IN
cord-022290-p0l1kv6n	22	7	various	various	JJ
cord-022290-p0l1kv6n	22	8	Picornaviruses	Picornaviruses	NNP
cord-022290-p0l1kv6n	22	9	and	and	CC
cord-022290-p0l1kv6n	22	10	in	in	IN
cord-022290-p0l1kv6n	22	11	some	some	DT
cord-022290-p0l1kv6n	22	12	cases	case	NNS
cord-022290-p0l1kv6n	22	13	are	be	VBP
cord-022290-p0l1kv6n	22	14	not	not	RB
cord-022290-p0l1kv6n	22	15	yet	yet	RB
cord-022290-p0l1kv6n	22	16	known	know	VBN
cord-022290-p0l1kv6n	22	17	.	.	.
cord-022290-p0l1kv6n	23	1	Following	follow	VBG
cord-022290-p0l1kv6n	23	2	attachment	attachment	NN
cord-022290-p0l1kv6n	23	3	,	,	,
cord-022290-p0l1kv6n	23	4	the	the	DT
cord-022290-p0l1kv6n	23	5	virus	virus	NN
cord-022290-p0l1kv6n	23	6	particles	particle	NNS
cord-022290-p0l1kv6n	23	7	lose	lose	VBP
cord-022290-p0l1kv6n	23	8	the	the	DT
cord-022290-p0l1kv6n	23	9	VP4	vp4	JJ
cord-022290-p0l1kv6n	23	10	protein	protein	NN
cord-022290-p0l1kv6n	23	11	and	and	CC
cord-022290-p0l1kv6n	23	12	undergo	undergo	VB
cord-022290-p0l1kv6n	23	13	a	a	DT
cord-022290-p0l1kv6n	23	14	change	change	NN
cord-022290-p0l1kv6n	23	15	that	that	WDT
cord-022290-p0l1kv6n	23	16	allows	allow	VBZ
cord-022290-p0l1kv6n	23	17	them	-PRON-	PRP
cord-022290-p0l1kv6n	23	18	to	to	TO
cord-022290-p0l1kv6n	23	19	release	release	VB
cord-022290-p0l1kv6n	23	20	their	-PRON-	PRP$
cord-022290-p0l1kv6n	23	21	RNA	RNA	NNP
cord-022290-p0l1kv6n	23	22	genome	genome	NN
cord-022290-p0l1kv6n	23	23	into	into	IN
cord-022290-p0l1kv6n	23	24	the	the	DT
cord-022290-p0l1kv6n	23	25	cystosol	cystosol	NN
cord-022290-p0l1kv6n	23	26	of	of	IN
cord-022290-p0l1kv6n	23	27	the	the	DT
cord-022290-p0l1kv6n	23	28	host	host	NN
cord-022290-p0l1kv6n	23	29	cell	cell	NN
cord-022290-p0l1kv6n	23	30	.	.	.
cord-022290-p0l1kv6n	24	1	Picornaviral	Picornaviral	NNP
cord-022290-p0l1kv6n	24	2	RNA	RNA	NNP
cord-022290-p0l1kv6n	24	3	genomes	genome	NNS
cord-022290-p0l1kv6n	24	4	have	have	VBP
cord-022290-p0l1kv6n	24	5	a	a	DT
cord-022290-p0l1kv6n	24	6	small	small	JJ
cord-022290-p0l1kv6n	24	7	,	,	,
cord-022290-p0l1kv6n	24	8	viral	viral	JJ
cord-022290-p0l1kv6n	24	9	protein	protein	NN
cord-022290-p0l1kv6n	24	10	(	(	-LRB-
cord-022290-p0l1kv6n	24	11	VPg	VPg	NNS
cord-022290-p0l1kv6n	24	12	,	,	,
cord-022290-p0l1kv6n	24	13	the	the	DT
cord-022290-p0l1kv6n	24	14	3B	3B	NNP
cord-022290-p0l1kv6n	24	15	gene	gene	NN
cord-022290-p0l1kv6n	24	16	product	product	NN
cord-022290-p0l1kv6n	24	17	)	)	-RRB-
cord-022290-p0l1kv6n	24	18	covalently	covalently	RB
cord-022290-p0l1kv6n	24	19	attached	attach	VBN
cord-022290-p0l1kv6n	24	20	at	at	IN
cord-022290-p0l1kv6n	24	21	the	the	DT
cord-022290-p0l1kv6n	24	22	5	5	CD
cord-022290-p0l1kv6n	24	23	'	'	NN
cord-022290-p0l1kv6n	24	24	terminus	terminus	NN
cord-022290-p0l1kv6n	24	25	.	.	.
cord-022290-p0l1kv6n	25	1	After	after	IN
cord-022290-p0l1kv6n	25	2	releasing	release	VBG
cord-022290-p0l1kv6n	25	3	the	the	DT
cord-022290-p0l1kv6n	25	4	RNA	RNA	NNP
cord-022290-p0l1kv6n	25	5	into	into	IN
cord-022290-p0l1kv6n	25	6	the	the	DT
cord-022290-p0l1kv6n	25	7	cytosol	cytosol	NN
cord-022290-p0l1kv6n	25	8	of	of	IN
cord-022290-p0l1kv6n	25	9	a	a	DT
cord-022290-p0l1kv6n	25	10	host	host	NN
cord-022290-p0l1kv6n	25	11	cell	cell	NN
cord-022290-p0l1kv6n	25	12	VPg	VPg	NNS
cord-022290-p0l1kv6n	25	13	is	be	VBZ
cord-022290-p0l1kv6n	25	14	cleaved	cleave	VBN
cord-022290-p0l1kv6n	25	15	off	off	RP
cord-022290-p0l1kv6n	25	16	by	by	IN
cord-022290-p0l1kv6n	25	17	a	a	DT
cord-022290-p0l1kv6n	25	18	cellular	cellular	JJ
cord-022290-p0l1kv6n	25	19	enzyme	enzyme	NN
cord-022290-p0l1kv6n	25	20	to	to	TO
cord-022290-p0l1kv6n	25	21	yield	yield	VB
cord-022290-p0l1kv6n	25	22	a	a	DT
cord-022290-p0l1kv6n	25	23	functional	functional	JJ
cord-022290-p0l1kv6n	25	24	mRNA	mrna	NN
cord-022290-p0l1kv6n	25	25	.	.	.
cord-022290-p0l1kv6n	26	1	The	the	DT
cord-022290-p0l1kv6n	26	2	RNA	RNA	NNP
cord-022290-p0l1kv6n	26	3	is	be	VBZ
cord-022290-p0l1kv6n	26	4	then	then	RB
cord-022290-p0l1kv6n	26	5	translated	translate	VBN
cord-022290-p0l1kv6n	26	6	into	into	IN
cord-022290-p0l1kv6n	26	7	a	a	DT
cord-022290-p0l1kv6n	26	8	large	large	JJ
cord-022290-p0l1kv6n	26	9	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	26	10	which	which	WDT
cord-022290-p0l1kv6n	26	11	is	be	VBZ
cord-022290-p0l1kv6n	26	12	cotranslationally	cotranslationally	RB
cord-022290-p0l1kv6n	26	13	proteolytically	proteolytically	RB
cord-022290-p0l1kv6n	26	14	processed	process	VBN
cord-022290-p0l1kv6n	26	15	into	into	IN
cord-022290-p0l1kv6n	26	16	the	the	DT
cord-022290-p0l1kv6n	26	17	individual	individual	JJ
cord-022290-p0l1kv6n	26	18	viral	viral	JJ
cord-022290-p0l1kv6n	26	19	proteins	protein	NNS
cord-022290-p0l1kv6n	26	20	(	(	-LRB-
cord-022290-p0l1kv6n	26	21	Palmenberg	Palmenberg	NNP
cord-022290-p0l1kv6n	26	22	,	,	,
cord-022290-p0l1kv6n	26	23	1990	1990	CD
cord-022290-p0l1kv6n	26	24	)	)	-RRB-
cord-022290-p0l1kv6n	26	25	.	.	.
cord-022290-p0l1kv6n	27	1	Under	under	IN
cord-022290-p0l1kv6n	27	2	normal	normal	JJ
cord-022290-p0l1kv6n	27	3	conditions	condition	NNS
cord-022290-p0l1kv6n	27	4	the	the	DT
cord-022290-p0l1kv6n	27	5	full	full	JJ
cord-022290-p0l1kv6n	27	6	-	-	HYPH
cord-022290-p0l1kv6n	27	7	length	length	NN
cord-022290-p0l1kv6n	27	8	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	27	9	is	be	VBZ
cord-022290-p0l1kv6n	27	10	never	never	RB
cord-022290-p0l1kv6n	27	11	found	find	VBN
cord-022290-p0l1kv6n	27	12	.	.	.
cord-022290-p0l1kv6n	28	1	Proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	28	2	processing	processing	NN
cord-022290-p0l1kv6n	28	3	of	of	IN
cord-022290-p0l1kv6n	28	4	the	the	DT
cord-022290-p0l1kv6n	28	5	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	28	6	is	be	VBZ
cord-022290-p0l1kv6n	28	7	accomplished	accomplish	VBN
cord-022290-p0l1kv6n	28	8	by	by	IN
cord-022290-p0l1kv6n	28	9	one	one	CD
cord-022290-p0l1kv6n	28	10	or	or	CC
cord-022290-p0l1kv6n	28	11	two	two	CD
cord-022290-p0l1kv6n	28	12	viral	viral	JJ
cord-022290-p0l1kv6n	28	13	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	28	14	which	which	WDT
cord-022290-p0l1kv6n	28	15	are	be	VBP
cord-022290-p0l1kv6n	28	16	themselves	-PRON-	PRP
cord-022290-p0l1kv6n	28	17	part	part	NN
cord-022290-p0l1kv6n	28	18	of	of	IN
cord-022290-p0l1kv6n	28	19	the	the	DT
cord-022290-p0l1kv6n	28	20	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	28	21	.	.	.
cord-022290-p0l1kv6n	29	1	The	the	DT
cord-022290-p0l1kv6n	29	2	first	first	JJ
cord-022290-p0l1kv6n	29	3	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	29	4	cleavage	cleavage	NN
cord-022290-p0l1kv6n	29	5	usually	usually	RB
cord-022290-p0l1kv6n	29	6	separates	separate	VBZ
cord-022290-p0l1kv6n	29	7	the	the	DT
cord-022290-p0l1kv6n	29	8	structural	structural	JJ
cord-022290-p0l1kv6n	29	9	proteins	protein	NNS
cord-022290-p0l1kv6n	29	10	(	(	-LRB-
cord-022290-p0l1kv6n	29	11	P1	P1	NNP
cord-022290-p0l1kv6n	29	12	in	in	IN
cord-022290-p0l1kv6n	29	13	Picornaviruses	Picornaviruses	NNP
cord-022290-p0l1kv6n	29	14	)	)	-RRB-
cord-022290-p0l1kv6n	29	15	from	from	IN
cord-022290-p0l1kv6n	29	16	the	the	DT
cord-022290-p0l1kv6n	29	17	remainder	remainder	NN
cord-022290-p0l1kv6n	29	18	of	of	IN
cord-022290-p0l1kv6n	29	19	the	the	DT
cord-022290-p0l1kv6n	29	20	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	29	21	.	.	.
cord-022290-p0l1kv6n	30	1	The	the	DT
cord-022290-p0l1kv6n	30	2	RNA	RNA	NNP
cord-022290-p0l1kv6n	30	3	genome	genome	NN
cord-022290-p0l1kv6n	30	4	is	be	VBZ
cord-022290-p0l1kv6n	30	5	also	also	RB
cord-022290-p0l1kv6n	30	6	replicated	replicate	VBN
cord-022290-p0l1kv6n	30	7	to	to	TO
cord-022290-p0l1kv6n	30	8	yield	yield	VB
cord-022290-p0l1kv6n	30	9	negative	negative	JJ
cord-022290-p0l1kv6n	30	10	-	-	HYPH
cord-022290-p0l1kv6n	30	11	sense	sense	NN
cord-022290-p0l1kv6n	30	12	RNAs	rna	NNS
cord-022290-p0l1kv6n	30	13	.	.	.
cord-022290-p0l1kv6n	31	1	The	the	DT
cord-022290-p0l1kv6n	31	2	negative	negative	JJ
cord-022290-p0l1kv6n	31	3	-	-	HYPH
cord-022290-p0l1kv6n	31	4	sense	sense	NN
cord-022290-p0l1kv6n	31	5	RNAs	rna	NNS
cord-022290-p0l1kv6n	31	6	then	then	RB
cord-022290-p0l1kv6n	31	7	serve	serve	VBP
cord-022290-p0l1kv6n	31	8	as	as	IN
cord-022290-p0l1kv6n	31	9	templates	template	NNS
cord-022290-p0l1kv6n	31	10	for	for	IN
cord-022290-p0l1kv6n	31	11	the	the	DT
cord-022290-p0l1kv6n	31	12	production	production	NN
cord-022290-p0l1kv6n	31	13	of	of	IN
cord-022290-p0l1kv6n	31	14	viral	viral	JJ
cord-022290-p0l1kv6n	31	15	genomes	genome	NNS
cord-022290-p0l1kv6n	31	16	.	.	.
cord-022290-p0l1kv6n	32	1	Picornaviral	Picornaviral	NNP
cord-022290-p0l1kv6n	32	2	RNA	RNA	NNP
cord-022290-p0l1kv6n	32	3	replication	replication	NN
cord-022290-p0l1kv6n	32	4	is	be	VBZ
cord-022290-p0l1kv6n	32	5	accomplished	accomplish	VBN
cord-022290-p0l1kv6n	32	6	by	by	IN
cord-022290-p0l1kv6n	32	7	a	a	DT
cord-022290-p0l1kv6n	32	8	multienzyme	multienzyme	NNS
cord-022290-p0l1kv6n	32	9	complex	complex	NN
cord-022290-p0l1kv6n	32	10	that	that	WDT
cord-022290-p0l1kv6n	32	11	includes	include	VBZ
cord-022290-p0l1kv6n	32	12	the	the	DT
cord-022290-p0l1kv6n	32	13	viral	viral	JJ
cord-022290-p0l1kv6n	32	14	RNA	RNA	NNP
cord-022290-p0l1kv6n	32	15	-	-	HYPH
cord-022290-p0l1kv6n	32	16	dependent	dependent	JJ
cord-022290-p0l1kv6n	32	17	RNA	RNA	NNP
cord-022290-p0l1kv6n	32	18	polymerase	polymerase	NN
cord-022290-p0l1kv6n	32	19	(	(	-LRB-
cord-022290-p0l1kv6n	32	20	3D	3D	NNP
cord-022290-p0l1kv6n	32	21	)	)	-RRB-
cord-022290-p0l1kv6n	32	22	,	,	,
cord-022290-p0l1kv6n	32	23	the	the	DT
cord-022290-p0l1kv6n	32	24	putative	putative	JJ
cord-022290-p0l1kv6n	32	25	viral	viral	JJ
cord-022290-p0l1kv6n	32	26	RNA	RNA	NNP
cord-022290-p0l1kv6n	32	27	helicase	helicase	NNP
cord-022290-p0l1kv6n	32	28	(	(	-LRB-
cord-022290-p0l1kv6n	32	29	2C	2C	NNP
cord-022290-p0l1kv6n	32	30	)	)	-RRB-
cord-022290-p0l1kv6n	32	31	,	,	,
cord-022290-p0l1kv6n	32	32	and	and	CC
cord-022290-p0l1kv6n	32	33	the	the	DT
cord-022290-p0l1kv6n	32	34	picornavrial	picornavrial	JJ
cord-022290-p0l1kv6n	32	35	3C	3C	NNP
cord-022290-p0l1kv6n	32	36	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	32	37	(	(	-LRB-
cord-022290-p0l1kv6n	32	38	Porter	Porter	NNP
cord-022290-p0l1kv6n	32	39	,	,	,
cord-022290-p0l1kv6n	32	40	1993	1993	CD
cord-022290-p0l1kv6n	32	41	;	;	:
cord-022290-p0l1kv6n	32	42	Wimmer	Wimmer	NNP
cord-022290-p0l1kv6n	32	43	et	et	NNP
cord-022290-p0l1kv6n	32	44	al	al	NNP
cord-022290-p0l1kv6n	32	45	.	.	NNP
cord-022290-p0l1kv6n	32	46	,	,	,
cord-022290-p0l1kv6n	32	47	1993	1993	CD
cord-022290-p0l1kv6n	32	48	)	)	-RRB-
cord-022290-p0l1kv6n	32	49	.	.	.
cord-022290-p0l1kv6n	33	1	Also	also	RB
cord-022290-p0l1kv6n	33	2	part	part	NN
cord-022290-p0l1kv6n	33	3	of	of	IN
cord-022290-p0l1kv6n	33	4	this	this	DT
cord-022290-p0l1kv6n	33	5	complex	complex	NN
cord-022290-p0l1kv6n	33	6	is	be	VBZ
cord-022290-p0l1kv6n	33	7	the	the	DT
cord-022290-p0l1kv6n	33	8	3AB	3AB	NNP
cord-022290-p0l1kv6n	33	9	gene	gene	NN
cord-022290-p0l1kv6n	33	10	product	product	NN
cord-022290-p0l1kv6n	33	11	.	.	.
cord-022290-p0l1kv6n	34	1	The	the	DT
cord-022290-p0l1kv6n	34	2	3A	3a	CD
cord-022290-p0l1kv6n	34	3	gene	gene	NN
cord-022290-p0l1kv6n	34	4	product	product	NN
cord-022290-p0l1kv6n	34	5	presumably	presumably	RB
cord-022290-p0l1kv6n	34	6	anchors	anchor	VBZ
cord-022290-p0l1kv6n	34	7	the	the	DT
cord-022290-p0l1kv6n	34	8	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	34	9	RNA	RNA	NNP
cord-022290-p0l1kv6n	34	10	replication	replication	NN
cord-022290-p0l1kv6n	34	11	complex	complex	JJ
cord-022290-p0l1kv6n	34	12	to	to	IN
cord-022290-p0l1kv6n	34	13	the	the	DT
cord-022290-p0l1kv6n	34	14	membrane	membrane	NN
cord-022290-p0l1kv6n	34	15	of	of	IN
cord-022290-p0l1kv6n	34	16	the	the	DT
cord-022290-p0l1kv6n	34	17	smooth	smooth	JJ
cord-022290-p0l1kv6n	34	18	ER	er	NN
cord-022290-p0l1kv6n	34	19	.	.	.
cord-022290-p0l1kv6n	35	1	Modification	modification	NN
cord-022290-p0l1kv6n	35	2	of	of	IN
cord-022290-p0l1kv6n	35	3	the	the	DT
cord-022290-p0l1kv6n	35	4	membrane	membrane	NN
cord-022290-p0l1kv6n	35	5	structure	structure	NN
cord-022290-p0l1kv6n	35	6	of	of	IN
cord-022290-p0l1kv6n	35	7	the	the	DT
cord-022290-p0l1kv6n	35	8	host	host	NN
cord-022290-p0l1kv6n	35	9	cell	cell	NN
cord-022290-p0l1kv6n	35	10	is	be	VBZ
cord-022290-p0l1kv6n	35	11	a	a	DT
cord-022290-p0l1kv6n	35	12	common	common	JJ
cord-022290-p0l1kv6n	35	13	feature	feature	NN
cord-022290-p0l1kv6n	35	14	of	of	IN
cord-022290-p0l1kv6n	35	15	picornavirus	picornavirus	NN
cord-022290-p0l1kv6n	35	16	infection	infection	NN
cord-022290-p0l1kv6n	35	17	(	(	-LRB-
cord-022290-p0l1kv6n	35	18	Bienz	Bienz	NNP
cord-022290-p0l1kv6n	35	19	et	et	NNP
cord-022290-p0l1kv6n	35	20	al	al	NNP
cord-022290-p0l1kv6n	35	21	.	.	NNP
cord-022290-p0l1kv6n	35	22	,	,	,
cord-022290-p0l1kv6n	35	23	1983	1983	CD
cord-022290-p0l1kv6n	36	1	(	(	-LRB-
cord-022290-p0l1kv6n	36	2	Bienz	Bienz	NNP
cord-022290-p0l1kv6n	36	3	et	et	NNP
cord-022290-p0l1kv6n	36	4	al	al	NNP
cord-022290-p0l1kv6n	36	5	.	.	.
cord-022290-p0l1kv6n	37	1	,	,	,
cord-022290-p0l1kv6n	37	2	,	,	,
cord-022290-p0l1kv6n	37	3	1990	1990	CD
cord-022290-p0l1kv6n	37	4	Teterina	Teterina	NNP
cord-022290-p0l1kv6n	37	5	et	et	NNP
cord-022290-p0l1kv6n	37	6	al	al	NNP
cord-022290-p0l1kv6n	37	7	.	.	NNP
cord-022290-p0l1kv6n	37	8	,	,	,
cord-022290-p0l1kv6n	37	9	1997a	1997a	CD
cord-022290-p0l1kv6n	37	10	,	,	,
cord-022290-p0l1kv6n	37	11	b	b	LS
cord-022290-p0l1kv6n	37	12	)	)	-RRB-
cord-022290-p0l1kv6n	37	13	.	.	.
cord-022290-p0l1kv6n	38	1	The	the	DT
cord-022290-p0l1kv6n	38	2	3B	3b	CD
cord-022290-p0l1kv6n	38	3	gene	gene	NN
cord-022290-p0l1kv6n	38	4	product	product	NN
cord-022290-p0l1kv6n	38	5	constitutes	constitute	VBZ
cord-022290-p0l1kv6n	38	6	VPg	VPg	NNS
cord-022290-p0l1kv6n	38	7	--	--	:
cord-022290-p0l1kv6n	38	8	the	the	DT
cord-022290-p0l1kv6n	38	9	viral	viral	JJ
cord-022290-p0l1kv6n	38	10	genome	genome	NN
cord-022290-p0l1kv6n	38	11	-	-	HYPH
cord-022290-p0l1kv6n	38	12	associated	associate	VBN
cord-022290-p0l1kv6n	38	13	protein	protein	NN
cord-022290-p0l1kv6n	38	14	--	--	:
cord-022290-p0l1kv6n	38	15	which	which	WDT
cord-022290-p0l1kv6n	38	16	remains	remain	VBZ
cord-022290-p0l1kv6n	38	17	covalently	covalently	RB
cord-022290-p0l1kv6n	38	18	bound	bind	VBN
cord-022290-p0l1kv6n	38	19	to	to	IN
cord-022290-p0l1kv6n	38	20	the	the	DT
cord-022290-p0l1kv6n	38	21	5'-end	5'-end	CD
cord-022290-p0l1kv6n	38	22	of	of	IN
cord-022290-p0l1kv6n	38	23	the	the	DT
cord-022290-p0l1kv6n	38	24	viral	viral	JJ
cord-022290-p0l1kv6n	38	25	RNA	RNA	NNP
cord-022290-p0l1kv6n	38	26	genome	genome	NN
cord-022290-p0l1kv6n	38	27	(	(	-LRB-
cord-022290-p0l1kv6n	38	28	Wimmer	Wimmer	NNP
cord-022290-p0l1kv6n	38	29	,	,	,
cord-022290-p0l1kv6n	38	30	1982	1982	CD
cord-022290-p0l1kv6n	38	31	)	)	-RRB-
cord-022290-p0l1kv6n	38	32	.	.	.
cord-022290-p0l1kv6n	39	1	There	there	EX
cord-022290-p0l1kv6n	39	2	is	be	VBZ
cord-022290-p0l1kv6n	39	3	also	also	RB
cord-022290-p0l1kv6n	39	4	evidence	evidence	NN
cord-022290-p0l1kv6n	39	5	that	that	IN
cord-022290-p0l1kv6n	39	6	some	some	DT
cord-022290-p0l1kv6n	39	7	cellular	cellular	JJ
cord-022290-p0l1kv6n	39	8	proteins	protein	NNS
cord-022290-p0l1kv6n	39	9	or	or	CC
cord-022290-p0l1kv6n	39	10	their	-PRON-	PRP$
cord-022290-p0l1kv6n	39	11	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	39	12	cleavage	cleavage	NN
cord-022290-p0l1kv6n	39	13	products	product	NNS
cord-022290-p0l1kv6n	39	14	form	form	VBP
cord-022290-p0l1kv6n	39	15	part	part	NN
cord-022290-p0l1kv6n	39	16	of	of	IN
cord-022290-p0l1kv6n	39	17	the	the	DT
cord-022290-p0l1kv6n	39	18	viral	viral	JJ
cord-022290-p0l1kv6n	39	19	RNA	RNA	NNP
cord-022290-p0l1kv6n	39	20	replicase	replicase	NN
cord-022290-p0l1kv6n	39	21	complex	complex	NN
cord-022290-p0l1kv6n	39	22	(	(	-LRB-
cord-022290-p0l1kv6n	39	23	Andino	Andino	NNP
cord-022290-p0l1kv6n	39	24	et	et	NNP
cord-022290-p0l1kv6n	39	25	al	al	NNP
cord-022290-p0l1kv6n	39	26	.	.	NNP
cord-022290-p0l1kv6n	39	27	,	,	,
cord-022290-p0l1kv6n	39	28	1993	1993	CD
cord-022290-p0l1kv6n	39	29	;	;	:
cord-022290-p0l1kv6n	40	1	Xiang	Xiang	NNP
cord-022290-p0l1kv6n	40	2	et	et	NNP
cord-022290-p0l1kv6n	40	3	al	al	NNP
cord-022290-p0l1kv6n	40	4	.	.	.
cord-022290-p0l1kv6n	41	1	,	,	,
cord-022290-p0l1kv6n	41	2	1995	1995	CD
cord-022290-p0l1kv6n	41	3	;	;	:
cord-022290-p0l1kv6n	41	4	Gamarnik	Gamarnik	NNP
cord-022290-p0l1kv6n	41	5	et	et	FW
cord-022290-p0l1kv6n	41	6	al	al	NNP
cord-022290-p0l1kv6n	41	7	.	.	NNP
cord-022290-p0l1kv6n	41	8	,	,	,
cord-022290-p0l1kv6n	41	9	1996	1996	CD
cord-022290-p0l1kv6n	41	10	;	;	.
cord-022290-p0l1kv6n	42	1	Parsley	Parsley	NNP
cord-022290-p0l1kv6n	42	2	et	et	NNP
cord-022290-p0l1kv6n	42	3	al	al	NNP
cord-022290-p0l1kv6n	42	4	.	.	NNP
cord-022290-p0l1kv6n	42	5	,	,	,
cord-022290-p0l1kv6n	42	6	1996	1996	CD
cord-022290-p0l1kv6n	42	7	)	)	-RRB-
cord-022290-p0l1kv6n	42	8	.	.	.
cord-022290-p0l1kv6n	43	1	Picornaviral	Picornaviral	NNP
cord-022290-p0l1kv6n	43	2	3C	3C	NNP
cord-022290-p0l1kv6n	43	3	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	43	4	possess	possess	VBP
cord-022290-p0l1kv6n	43	5	an	an	DT
cord-022290-p0l1kv6n	43	6	RNA	RNA	NNP
cord-022290-p0l1kv6n	43	7	binding	binding	NN
cord-022290-p0l1kv6n	43	8	site	site	NN
cord-022290-p0l1kv6n	43	9	and	and	CC
cord-022290-p0l1kv6n	43	10	RNA	RNA	NNP
cord-022290-p0l1kv6n	43	11	binding	binding	NN
cord-022290-p0l1kv6n	43	12	activity	activity	NN
cord-022290-p0l1kv6n	43	13	that	that	WDT
cord-022290-p0l1kv6n	43	14	is	be	VBZ
cord-022290-p0l1kv6n	43	15	distinct	distinct	JJ
cord-022290-p0l1kv6n	43	16	from	from	IN
cord-022290-p0l1kv6n	43	17	its	-PRON-	PRP$
cord-022290-p0l1kv6n	43	18	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	43	19	activity	activity	NN
cord-022290-p0l1kv6n	43	20	(	(	-LRB-
cord-022290-p0l1kv6n	43	21	H	h	NN
cord-022290-p0l1kv6n	43	22	~	~	NFP
cord-022290-p0l1kv6n	43	23	immerle	immerle	NNP
cord-022290-p0l1kv6n	43	24	et	et	FW
cord-022290-p0l1kv6n	43	25	al	al	NNP
cord-022290-p0l1kv6n	43	26	.	.	NNP
cord-022290-p0l1kv6n	43	27	,	,	,
cord-022290-p0l1kv6n	43	28	1992	1992	CD
cord-022290-p0l1kv6n	43	29	;	;	.
cord-022290-p0l1kv6n	44	1	Andino	Andino	NNP
cord-022290-p0l1kv6n	44	2	et	et	NNP
cord-022290-p0l1kv6n	44	3	al	al	NNP
cord-022290-p0l1kv6n	44	4	.	.	NNP
cord-022290-p0l1kv6n	44	5	,	,	,
cord-022290-p0l1kv6n	44	6	1993	1993	CD
cord-022290-p0l1kv6n	45	1	;	;	:
cord-022290-p0l1kv6n	45	2	Porter	Porter	NNP
cord-022290-p0l1kv6n	45	3	et	et	NNP
cord-022290-p0l1kv6n	45	4	al	al	NNP
cord-022290-p0l1kv6n	45	5	.	.	.
cord-022290-p0l1kv6n	46	1	,	,	,
cord-022290-p0l1kv6n	46	2	1993	1993	CD
cord-022290-p0l1kv6n	46	3	;	;	:
cord-022290-p0l1kv6n	46	4	Walker	Walker	NNP
cord-022290-p0l1kv6n	46	5	et	et	NNP
cord-022290-p0l1kv6n	46	6	al	al	NNP
cord-022290-p0l1kv6n	46	7	.	.	NNP
cord-022290-p0l1kv6n	46	8	,	,	,
cord-022290-p0l1kv6n	46	9	1995	1995	CD
cord-022290-p0l1kv6n	46	10	;	;	:
cord-022290-p0l1kv6n	46	11	Kusov	Kusov	NNP
cord-022290-p0l1kv6n	46	12	and	and	CC
cord-022290-p0l1kv6n	46	13	Gauss	Gauss	NNP
cord-022290-p0l1kv6n	46	14	-	-	HYPH
cord-022290-p0l1kv6n	46	15	M	M	NNP
cord-022290-p0l1kv6n	46	16	~	~	NNP
cord-022290-p0l1kv6n	46	17	iller	iller	NN
cord-022290-p0l1kv6n	46	18	,	,	,
cord-022290-p0l1kv6n	46	19	1997	1997	CD
cord-022290-p0l1kv6n	46	20	)	)	-RRB-
cord-022290-p0l1kv6n	46	21	.	.	.
cord-022290-p0l1kv6n	47	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	47	2	is	be	VBZ
cord-022290-p0l1kv6n	47	3	common	common	JJ
cord-022290-p0l1kv6n	47	4	for	for	IN
cord-022290-p0l1kv6n	47	5	the	the	DT
cord-022290-p0l1kv6n	47	6	limited	limited	JJ
cord-022290-p0l1kv6n	47	7	number	number	NN
cord-022290-p0l1kv6n	47	8	of	of	IN
cord-022290-p0l1kv6n	47	9	gene	gene	NN
cord-022290-p0l1kv6n	47	10	products	product	NNS
cord-022290-p0l1kv6n	47	11	of	of	IN
cord-022290-p0l1kv6n	47	12	small	small	JJ
cord-022290-p0l1kv6n	47	13	RNA	RNA	NNP
cord-022290-p0l1kv6n	47	14	viruses	virus	NNS
cord-022290-p0l1kv6n	47	15	to	to	TO
cord-022290-p0l1kv6n	47	16	perform	perform	VB
cord-022290-p0l1kv6n	47	17	multiple	multiple	JJ
cord-022290-p0l1kv6n	47	18	,	,	,
cord-022290-p0l1kv6n	47	19	distinct	distinct	JJ
cord-022290-p0l1kv6n	47	20	functions	function	NNS
cord-022290-p0l1kv6n	47	21	.	.	.
cord-022290-p0l1kv6n	48	1	The	the	DT
cord-022290-p0l1kv6n	48	2	exact	exact	JJ
cord-022290-p0l1kv6n	48	3	function	function	NN
cord-022290-p0l1kv6n	48	4	of	of	IN
cord-022290-p0l1kv6n	48	5	the	the	DT
cord-022290-p0l1kv6n	48	6	3C	3c	NN
cord-022290-p0l1kv6n	48	7	proteinase	proteinase	NN
cord-022290-p0l1kv6n	48	8	within	within	IN
cord-022290-p0l1kv6n	48	9	the	the	DT
cord-022290-p0l1kv6n	48	10	RNA	RNA	NNP
cord-022290-p0l1kv6n	48	11	replicase	replicase	NN
cord-022290-p0l1kv6n	48	12	complex	complex	NN
cord-022290-p0l1kv6n	48	13	is	be	VBZ
cord-022290-p0l1kv6n	48	14	not	not	RB
cord-022290-p0l1kv6n	48	15	clear	clear	JJ
cord-022290-p0l1kv6n	48	16	.	.	.
cord-022290-p0l1kv6n	49	1	Apparently	apparently	RB
cord-022290-p0l1kv6n	49	2	its	-PRON-	PRP$
cord-022290-p0l1kv6n	49	3	RNA	RNA	NNP
cord-022290-p0l1kv6n	49	4	binding	binding	NN
cord-022290-p0l1kv6n	49	5	activity	activity	NN
cord-022290-p0l1kv6n	49	6	is	be	VBZ
cord-022290-p0l1kv6n	49	7	required	require	VBN
cord-022290-p0l1kv6n	49	8	for	for	IN
cord-022290-p0l1kv6n	49	9	the	the	DT
cord-022290-p0l1kv6n	49	10	initiation	initiation	NN
cord-022290-p0l1kv6n	49	11	of	of	IN
cord-022290-p0l1kv6n	49	12	RNA	RNA	NNP
cord-022290-p0l1kv6n	49	13	replication	replication	NN
cord-022290-p0l1kv6n	49	14	.	.	.
cord-022290-p0l1kv6n	50	1	Certain	certain	JJ
cord-022290-p0l1kv6n	50	2	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	50	3	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	50	4	in	in	IN
cord-022290-p0l1kv6n	50	5	some	some	DT
cord-022290-p0l1kv6n	50	6	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	50	7	could	could	MD
cord-022290-p0l1kv6n	50	8	be	be	VB
cord-022290-p0l1kv6n	50	9	essential	essential	JJ
cord-022290-p0l1kv6n	50	10	steps	step	NNS
cord-022290-p0l1kv6n	50	11	during	during	IN
cord-022290-p0l1kv6n	50	12	RNA	RNA	NNP
cord-022290-p0l1kv6n	50	13	replication	replication	NN
cord-022290-p0l1kv6n	50	14	within	within	IN
cord-022290-p0l1kv6n	50	15	the	the	DT
cord-022290-p0l1kv6n	50	16	RNA	RNA	NNP
cord-022290-p0l1kv6n	50	17	replicase	replicase	NN
cord-022290-p0l1kv6n	50	18	complex	complex	NN
cord-022290-p0l1kv6n	50	19	,	,	.
cord-022290-p0l1kv6n	51	1	e.g.	e.g.	RB
cord-022290-p0l1kv6n	51	2	,	,	,
cord-022290-p0l1kv6n	51	3	the	the	DT
cord-022290-p0l1kv6n	51	4	3C	3c	NN
cord-022290-p0l1kv6n	51	5	-	-	HYPH
cord-022290-p0l1kv6n	51	6	mediated	mediate	VBN
cord-022290-p0l1kv6n	51	7	cleavage	cleavage	NN
cord-022290-p0l1kv6n	51	8	of	of	IN
cord-022290-p0l1kv6n	51	9	the	the	DT
cord-022290-p0l1kv6n	51	10	RNA	RNA	NNP
cord-022290-p0l1kv6n	51	11	-	-	HYPH
cord-022290-p0l1kv6n	51	12	associated	associate	VBN
cord-022290-p0l1kv6n	51	13	VPg	VPg	NNS
cord-022290-p0l1kv6n	51	14	(	(	-LRB-
cord-022290-p0l1kv6n	51	15	3B	3B	NNP
cord-022290-p0l1kv6n	51	16	)	)	-RRB-
cord-022290-p0l1kv6n	51	17	from	from	IN
cord-022290-p0l1kv6n	51	18	the	the	DT
cord-022290-p0l1kv6n	51	19	membrane	membrane	NN
cord-022290-p0l1kv6n	51	20	anchor	anchor	NN
cord-022290-p0l1kv6n	51	21	(	(	-LRB-
cord-022290-p0l1kv6n	51	22	3A	3A	NNP
cord-022290-p0l1kv6n	51	23	)	)	-RRB-
cord-022290-p0l1kv6n	51	24	may	may	MD
cord-022290-p0l1kv6n	51	25	be	be	VB
cord-022290-p0l1kv6n	51	26	necessary	necessary	JJ
cord-022290-p0l1kv6n	51	27	to	to	TO
cord-022290-p0l1kv6n	51	28	release	release	VB
cord-022290-p0l1kv6n	51	29	the	the	DT
cord-022290-p0l1kv6n	51	30	RNA	RNA	NNP
cord-022290-p0l1kv6n	51	31	from	from	IN
cord-022290-p0l1kv6n	51	32	the	the	DT
cord-022290-p0l1kv6n	51	33	membrane	membrane	NN
cord-022290-p0l1kv6n	51	34	-	-	HYPH
cord-022290-p0l1kv6n	51	35	bound	bind	VBN
cord-022290-p0l1kv6n	51	36	replicase	replicase	NN
cord-022290-p0l1kv6n	51	37	complex	complex	NN
cord-022290-p0l1kv6n	51	38	.	.	.
cord-022290-p0l1kv6n	52	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	52	2	is	be	VBZ
cord-022290-p0l1kv6n	52	3	also	also	RB
cord-022290-p0l1kv6n	52	4	believed	believe	VBN
cord-022290-p0l1kv6n	52	5	that	that	IN
cord-022290-p0l1kv6n	52	6	in	in	IN
cord-022290-p0l1kv6n	52	7	some	some	DT
cord-022290-p0l1kv6n	52	8	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	52	9	the	the	DT
cord-022290-p0l1kv6n	52	10	cleavage	cleavage	NN
cord-022290-p0l1kv6n	52	11	of	of	IN
cord-022290-p0l1kv6n	52	12	3CD	3cd	NN
cord-022290-p0l1kv6n	52	13	within	within	IN
cord-022290-p0l1kv6n	52	14	the	the	DT
cord-022290-p0l1kv6n	52	15	replicase	replicase	NN
cord-022290-p0l1kv6n	52	16	complex	complex	NN
cord-022290-p0l1kv6n	52	17	after	after	IN
cord-022290-p0l1kv6n	52	18	binding	bind	VBG
cord-022290-p0l1kv6n	52	19	of	of	IN
cord-022290-p0l1kv6n	52	20	the	the	DT
cord-022290-p0l1kv6n	52	21	RNA	RNA	NNP
cord-022290-p0l1kv6n	52	22	is	be	VBZ
cord-022290-p0l1kv6n	52	23	required	require	VBN
cord-022290-p0l1kv6n	52	24	to	to	TO
cord-022290-p0l1kv6n	52	25	allow	allow	VB
cord-022290-p0l1kv6n	52	26	3D	3D	NNP
cord-022290-p0l1kv6n	52	27	to	to	TO
cord-022290-p0l1kv6n	52	28	perform	perform	VB
cord-022290-p0l1kv6n	52	29	RNA	RNA	NNP
cord-022290-p0l1kv6n	52	30	replication	replication	NN
cord-022290-p0l1kv6n	52	31	(	(	-LRB-
cord-022290-p0l1kv6n	52	32	Harris	Harris	NNP
cord-022290-p0l1kv6n	52	33	et	et	NNP
cord-022290-p0l1kv6n	52	34	al	al	NNP
cord-022290-p0l1kv6n	52	35	.	.	NNP
cord-022290-p0l1kv6n	52	36	,	,	,
cord-022290-p0l1kv6n	52	37	1992	1992	CD
cord-022290-p0l1kv6n	52	38	;	;	:
cord-022290-p0l1kv6n	52	39	Molla	Molla	NNP
cord-022290-p0l1kv6n	52	40	et	et	NNP
cord-022290-p0l1kv6n	52	41	al	al	NNP
cord-022290-p0l1kv6n	52	42	.	.	NNP
cord-022290-p0l1kv6n	52	43	,	,	,
cord-022290-p0l1kv6n	52	44	1995	1995	CD
cord-022290-p0l1kv6n	52	45	)	)	-RRB-
cord-022290-p0l1kv6n	52	46	.	.	.
cord-022290-p0l1kv6n	53	1	Initially	initially	RB
cord-022290-p0l1kv6n	53	2	the	the	DT
cord-022290-p0l1kv6n	53	3	structural	structural	JJ
cord-022290-p0l1kv6n	53	4	proteins	protein	NNS
cord-022290-p0l1kv6n	53	5	(	(	-LRB-
cord-022290-p0l1kv6n	53	6	P	p	NN
cord-022290-p0l1kv6n	53	7	1	1	CD
cord-022290-p0l1kv6n	53	8	)	)	-RRB-
cord-022290-p0l1kv6n	53	9	are	be	VBP
cord-022290-p0l1kv6n	53	10	cleaved	cleave	VBN
cord-022290-p0l1kv6n	53	11	from	from	IN
cord-022290-p0l1kv6n	53	12	the	the	DT
cord-022290-p0l1kv6n	53	13	viral	viral	JJ
cord-022290-p0l1kv6n	53	14	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	53	15	.	.	.
cord-022290-p0l1kv6n	54	1	Two	two	CD
cord-022290-p0l1kv6n	54	2	more	more	JJR
cord-022290-p0l1kv6n	54	3	3C	3c	NN
cord-022290-p0l1kv6n	54	4	-	-	HYPH
cord-022290-p0l1kv6n	54	5	mediated	mediate	VBN
cord-022290-p0l1kv6n	54	6	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	54	7	(	(	-LRB-
cord-022290-p0l1kv6n	54	8	1AB]IC	1ab]ic	CD
cord-022290-p0l1kv6n	54	9	and	and	CC
cord-022290-p0l1kv6n	54	10	1CI1D	1ci1d	CD
cord-022290-p0l1kv6n	54	11	or	or	CC
cord-022290-p0l1kv6n	54	12	VP0]VP3	VP0]VP3	NNP
cord-022290-p0l1kv6n	54	13	and	and	CC
cord-022290-p0l1kv6n	54	14	VP3	VP3	NNP
cord-022290-p0l1kv6n	54	15	I	I	NNP
cord-022290-p0l1kv6n	54	16	VP	VP	NNP
cord-022290-p0l1kv6n	54	17	1	1	CD
cord-022290-p0l1kv6n	54	18	,	,	,
cord-022290-p0l1kv6n	54	19	respectively	respectively	RB
cord-022290-p0l1kv6n	54	20	)	)	-RRB-
cord-022290-p0l1kv6n	54	21	are	be	VBP
cord-022290-p0l1kv6n	54	22	required	require	VBN
cord-022290-p0l1kv6n	54	23	within	within	IN
cord-022290-p0l1kv6n	54	24	the	the	DT
cord-022290-p0l1kv6n	54	25	capsid	capsid	JJ
cord-022290-p0l1kv6n	54	26	precursor	precursor	NN
cord-022290-p0l1kv6n	54	27	.	.	.
cord-022290-p0l1kv6n	55	1	The	the	DT
cord-022290-p0l1kv6n	55	2	resulting	result	VBG
cord-022290-p0l1kv6n	55	3	protomer	protomer	NN
cord-022290-p0l1kv6n	55	4	then	then	RB
cord-022290-p0l1kv6n	55	5	assembles	assemble	VBZ
cord-022290-p0l1kv6n	55	6	into	into	IN
cord-022290-p0l1kv6n	55	7	pentamers	pentamer	NNS
cord-022290-p0l1kv6n	55	8	and	and	CC
cord-022290-p0l1kv6n	55	9	the	the	DT
cord-022290-p0l1kv6n	55	10	pentamers	pentamer	NNS
cord-022290-p0l1kv6n	55	11	form	form	VBP
cord-022290-p0l1kv6n	55	12	the	the	DT
cord-022290-p0l1kv6n	55	13	provirions	provirion	NNS
cord-022290-p0l1kv6n	55	14	by	by	IN
cord-022290-p0l1kv6n	55	15	a	a	DT
cord-022290-p0l1kv6n	55	16	poorly	poorly	RB
cord-022290-p0l1kv6n	55	17	understood	understand	VBN
cord-022290-p0l1kv6n	55	18	pathway	pathway	NN
cord-022290-p0l1kv6n	55	19	that	that	WDT
cord-022290-p0l1kv6n	55	20	requires	require	VBZ
cord-022290-p0l1kv6n	55	21	the	the	DT
cord-022290-p0l1kv6n	55	22	VPg	vpg	NN
cord-022290-p0l1kv6n	55	23	-	-	HYPH
cord-022290-p0l1kv6n	55	24	linked	link	VBN
cord-022290-p0l1kv6n	55	25	RNA	RNA	NNP
cord-022290-p0l1kv6n	55	26	genome	genome	NN
cord-022290-p0l1kv6n	55	27	.	.	.
cord-022290-p0l1kv6n	56	1	A	a	DT
cord-022290-p0l1kv6n	56	2	final	final	JJ
cord-022290-p0l1kv6n	56	3	maturation	maturation	NN
cord-022290-p0l1kv6n	56	4	cleavage	cleavage	NN
cord-022290-p0l1kv6n	56	5	within	within	IN
cord-022290-p0l1kv6n	56	6	the	the	DT
cord-022290-p0l1kv6n	56	7	provirion	provirion	NN
cord-022290-p0l1kv6n	56	8	(	(	-LRB-
cord-022290-p0l1kv6n	56	9	VP0	vp0	NN
cord-022290-p0l1kv6n	56	10	---	---	:
cord-022290-p0l1kv6n	56	11	>	>	XX
cord-022290-p0l1kv6n	56	12	VP2	vp2	NN
cord-022290-p0l1kv6n	56	13	+	+	CC
cord-022290-p0l1kv6n	56	14	VP4	VP4	NNP
cord-022290-p0l1kv6n	56	15	)	)	-RRB-
cord-022290-p0l1kv6n	56	16	yields	yield	VBZ
cord-022290-p0l1kv6n	56	17	the	the	DT
cord-022290-p0l1kv6n	56	18	infectious	infectious	JJ
cord-022290-p0l1kv6n	56	19	virus	virus	NN
cord-022290-p0l1kv6n	56	20	particles	particle	NNS
cord-022290-p0l1kv6n	56	21	.	.	.
cord-022290-p0l1kv6n	57	1	This	this	DT
cord-022290-p0l1kv6n	57	2	maturation	maturation	NN
cord-022290-p0l1kv6n	57	3	cleavage	cleavage	NN
cord-022290-p0l1kv6n	57	4	is	be	VBZ
cord-022290-p0l1kv6n	57	5	believed	believe	VBN
cord-022290-p0l1kv6n	57	6	to	to	TO
cord-022290-p0l1kv6n	57	7	be	be	VB
cord-022290-p0l1kv6n	57	8	nonenzymatic	nonenzymatic	JJ
cord-022290-p0l1kv6n	57	9	and	and	CC
cord-022290-p0l1kv6n	57	10	to	to	TO
cord-022290-p0l1kv6n	57	11	require	require	VB
cord-022290-p0l1kv6n	57	12	the	the	DT
cord-022290-p0l1kv6n	57	13	presence	presence	NN
cord-022290-p0l1kv6n	57	14	of	of	IN
cord-022290-p0l1kv6n	57	15	the	the	DT
cord-022290-p0l1kv6n	57	16	packaged	package	VBN
cord-022290-p0l1kv6n	57	17	RNA	rna	NN
cord-022290-p0l1kv6n	57	18	genome	genome	NN
cord-022290-p0l1kv6n	57	19	(	(	-LRB-
cord-022290-p0l1kv6n	57	20	Palmenberg	Palmenberg	NNP
cord-022290-p0l1kv6n	57	21	,	,	,
cord-022290-p0l1kv6n	57	22	1990	1990	CD
cord-022290-p0l1kv6n	57	23	;	;	:
cord-022290-p0l1kv6n	57	24	Rueckert	Rueckert	NNP
cord-022290-p0l1kv6n	57	25	,	,	,
cord-022290-p0l1kv6n	57	26	1996	1996	CD
cord-022290-p0l1kv6n	57	27	)	)	-RRB-
cord-022290-p0l1kv6n	58	1	Many	many	JJ
cord-022290-p0l1kv6n	58	2	details	detail	NNS
cord-022290-p0l1kv6n	58	3	such	such	JJ
cord-022290-p0l1kv6n	58	4	as	as	IN
cord-022290-p0l1kv6n	58	5	the	the	DT
cord-022290-p0l1kv6n	58	6	composition	composition	NN
cord-022290-p0l1kv6n	58	7	of	of	IN
cord-022290-p0l1kv6n	58	8	the	the	DT
cord-022290-p0l1kv6n	58	9	RNA	RNA	NNP
cord-022290-p0l1kv6n	58	10	replicase	replicase	NN
cord-022290-p0l1kv6n	58	11	complex	complex	NN
cord-022290-p0l1kv6n	58	12	,	,	,
cord-022290-p0l1kv6n	58	13	the	the	DT
cord-022290-p0l1kv6n	58	14	function	function	NN
cord-022290-p0l1kv6n	58	15	of	of	IN
cord-022290-p0l1kv6n	58	16	the	the	DT
cord-022290-p0l1kv6n	58	17	individual	individual	JJ
cord-022290-p0l1kv6n	58	18	components	component	NNS
cord-022290-p0l1kv6n	58	19	of	of	IN
cord-022290-p0l1kv6n	58	20	the	the	DT
cord-022290-p0l1kv6n	58	21	RNA	RNA	NNP
cord-022290-p0l1kv6n	58	22	replicase	replicase	NN
cord-022290-p0l1kv6n	58	23	complex	complex	NN
cord-022290-p0l1kv6n	58	24	,	,	,
cord-022290-p0l1kv6n	58	25	the	the	DT
cord-022290-p0l1kv6n	58	26	pathway	pathway	NN
cord-022290-p0l1kv6n	58	27	of	of	IN
cord-022290-p0l1kv6n	58	28	provirion	provirion	NNP
cord-022290-p0l1kv6n	58	29	assembly	assembly	NNP
cord-022290-p0l1kv6n	58	30	and	and	CC
cord-022290-p0l1kv6n	58	31	so	so	RB
cord-022290-p0l1kv6n	58	32	on	on	RB
cord-022290-p0l1kv6n	58	33	are	be	VBP
cord-022290-p0l1kv6n	58	34	,	,	,
cord-022290-p0l1kv6n	58	35	even	even	RB
cord-022290-p0l1kv6n	58	36	in	in	IN
cord-022290-p0l1kv6n	58	37	the	the	DT
cord-022290-p0l1kv6n	58	38	best	good	JJS
cord-022290-p0l1kv6n	58	39	studied	study	VBN
cord-022290-p0l1kv6n	58	40	viruses	virus	NNS
cord-022290-p0l1kv6n	58	41	,	,	,
cord-022290-p0l1kv6n	58	42	not	not	RB
cord-022290-p0l1kv6n	58	43	completely	completely	RB
cord-022290-p0l1kv6n	58	44	understood	understand	VBN
cord-022290-p0l1kv6n	58	45	.	.	.
cord-022290-p0l1kv6n	59	1	There	there	EX
cord-022290-p0l1kv6n	59	2	are	be	VBP
cord-022290-p0l1kv6n	59	3	also	also	RB
cord-022290-p0l1kv6n	59	4	differences	difference	NNS
cord-022290-p0l1kv6n	59	5	in	in	IN
cord-022290-p0l1kv6n	59	6	many	many	JJ
cord-022290-p0l1kv6n	59	7	aspects	aspect	NNS
cord-022290-p0l1kv6n	59	8	of	of	IN
cord-022290-p0l1kv6n	59	9	the	the	DT
cord-022290-p0l1kv6n	59	10	viral	viral	JJ
cord-022290-p0l1kv6n	59	11	life	life	NN
cord-022290-p0l1kv6n	59	12	cycle	cycle	NN
cord-022290-p0l1kv6n	59	13	between	between	IN
cord-022290-p0l1kv6n	59	14	the	the	DT
cord-022290-p0l1kv6n	59	15	individual	individual	JJ
cord-022290-p0l1kv6n	59	16	genera	genus	NNS
cord-022290-p0l1kv6n	59	17	of	of	IN
cord-022290-p0l1kv6n	59	18	the	the	DT
cord-022290-p0l1kv6n	59	19	Picornaviridae	Picornaviridae	NNP
cord-022290-p0l1kv6n	59	20	.	.	.
cord-022290-p0l1kv6n	60	1	The	the	DT
cord-022290-p0l1kv6n	60	2	genome	genome	NN
cord-022290-p0l1kv6n	60	3	of	of	IN
cord-022290-p0l1kv6n	60	4	all	all	DT
cord-022290-p0l1kv6n	60	5	picornaviruses	picornaviruses	NNP
cord-022290-p0l1kv6n	60	6	carries	carry	VBZ
cord-022290-p0l1kv6n	60	7	at	at	RB
cord-022290-p0l1kv6n	60	8	least	least	RBS
cord-022290-p0l1kv6n	60	9	one	one	CD
cord-022290-p0l1kv6n	60	10	,	,	,
cord-022290-p0l1kv6n	60	11	more	more	RBR
cord-022290-p0l1kv6n	60	12	often	often	RB
cord-022290-p0l1kv6n	60	13	two	two	CD
cord-022290-p0l1kv6n	60	14	,	,	,
cord-022290-p0l1kv6n	60	15	genes	gene	NNS
cord-022290-p0l1kv6n	60	16	encoding	encode	VBG
cord-022290-p0l1kv6n	60	17	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	60	18	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	60	19	.	.	.
cord-022290-p0l1kv6n	61	1	The	the	DT
cord-022290-p0l1kv6n	61	2	3C	3c	NN
cord-022290-p0l1kv6n	61	3	gene	gene	NN
cord-022290-p0l1kv6n	61	4	product	product	NN
cord-022290-p0l1kv6n	61	5	is	be	VBZ
cord-022290-p0l1kv6n	61	6	the	the	DT
cord-022290-p0l1kv6n	61	7	major	major	JJ
cord-022290-p0l1kv6n	61	8	processing	processing	NN
cord-022290-p0l1kv6n	61	9	proteinase	proteinase	NN
cord-022290-p0l1kv6n	61	10	in	in	IN
cord-022290-p0l1kv6n	61	11	all	all	DT
cord-022290-p0l1kv6n	61	12	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	61	13	.	.	.
cord-022290-p0l1kv6n	62	1	The	the	DT
cord-022290-p0l1kv6n	62	2	primary	primary	JJ
cord-022290-p0l1kv6n	62	3	function	function	NN
cord-022290-p0l1kv6n	62	4	of	of	IN
cord-022290-p0l1kv6n	62	5	the	the	DT
cord-022290-p0l1kv6n	62	6	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	62	7	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	62	8	is	be	VBZ
cord-022290-p0l1kv6n	62	9	the	the	DT
cord-022290-p0l1kv6n	62	10	cotranslational	cotranslational	JJ
cord-022290-p0l1kv6n	62	11	,	,	,
cord-022290-p0l1kv6n	62	12	specific	specific	JJ
cord-022290-p0l1kv6n	62	13	cleavage	cleavage	NN
cord-022290-p0l1kv6n	62	14	of	of	IN
cord-022290-p0l1kv6n	62	15	the	the	DT
cord-022290-p0l1kv6n	62	16	viral	viral	JJ
cord-022290-p0l1kv6n	62	17	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	62	18	into	into	IN
cord-022290-p0l1kv6n	62	19	the	the	DT
cord-022290-p0l1kv6n	62	20	structural	structural	JJ
cord-022290-p0l1kv6n	62	21	and	and	CC
cord-022290-p0l1kv6n	62	22	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	62	23	proteins	protein	NNS
cord-022290-p0l1kv6n	62	24	.	.	.
cord-022290-p0l1kv6n	63	1	The	the	DT
cord-022290-p0l1kv6n	63	2	individual	individual	JJ
cord-022290-p0l1kv6n	63	3	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	63	4	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	63	5	by	by	IN
cord-022290-p0l1kv6n	63	6	the	the	DT
cord-022290-p0l1kv6n	63	7	3C	3C	NNP
cord-022290-p0l1kv6n	63	8	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	63	9	within	within	IN
cord-022290-p0l1kv6n	63	10	the	the	DT
cord-022290-p0l1kv6n	63	11	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	63	12	polyproteins	polyprotein	NNS
cord-022290-p0l1kv6n	63	13	are	be	VBP
cord-022290-p0l1kv6n	63	14	sequential	sequential	JJ
cord-022290-p0l1kv6n	63	15	;	;	:
cord-022290-p0l1kv6n	63	16	some	some	DT
cord-022290-p0l1kv6n	63	17	sites	site	NNS
cord-022290-p0l1kv6n	63	18	are	be	VBP
cord-022290-p0l1kv6n	63	19	cleaved	cleave	VBN
cord-022290-p0l1kv6n	63	20	faster	fast	RBR
cord-022290-p0l1kv6n	63	21	then	then	RB
cord-022290-p0l1kv6n	63	22	others	other	NNS
cord-022290-p0l1kv6n	63	23	.	.	.
cord-022290-p0l1kv6n	64	1	The	the	DT
cord-022290-p0l1kv6n	64	2	cleavage	cleavage	NN
cord-022290-p0l1kv6n	64	3	sites	site	NNS
cord-022290-p0l1kv6n	64	4	are	be	VBP
cord-022290-p0l1kv6n	64	5	identified	identify	VBN
cord-022290-p0l1kv6n	64	6	by	by	IN
cord-022290-p0l1kv6n	64	7	the	the	DT
cord-022290-p0l1kv6n	64	8	sequence	sequence	NN
cord-022290-p0l1kv6n	64	9	of	of	IN
cord-022290-p0l1kv6n	64	10	the	the	DT
cord-022290-p0l1kv6n	64	11	residues	residue	NNS
cord-022290-p0l1kv6n	64	12	immediately	immediately	RB
cord-022290-p0l1kv6n	64	13	preceding	precede	VBG
cord-022290-p0l1kv6n	64	14	and	and	CC
cord-022290-p0l1kv6n	64	15	following	follow	VBG
cord-022290-p0l1kv6n	64	16	the	the	DT
cord-022290-p0l1kv6n	64	17	scissile	scissile	NNP
cord-022290-p0l1kv6n	64	18	bond	bond	NN
cord-022290-p0l1kv6n	64	19	(	(	-LRB-
cord-022290-p0l1kv6n	64	20	approximately	approximately	RB
cord-022290-p0l1kv6n	64	21	P4	P4	NNP
cord-022290-p0l1kv6n	64	22	to	to	IN
cord-022290-p0l1kv6n	64	23	P~	P~	NNP
cord-022290-p0l1kv6n	64	24	in	in	IN
cord-022290-p0l1kv6n	64	25	the	the	DT
cord-022290-p0l1kv6n	64	26	nomenclature	nomenclature	NN
cord-022290-p0l1kv6n	64	27	of	of	IN
cord-022290-p0l1kv6n	64	28	Schechter	Schechter	NNP
cord-022290-p0l1kv6n	64	29	and	and	CC
cord-022290-p0l1kv6n	64	30	Berger	Berger	NNP
cord-022290-p0l1kv6n	64	31	,	,	,
cord-022290-p0l1kv6n	64	32	1967	1967	CD
cord-022290-p0l1kv6n	64	33	)	)	-RRB-
cord-022290-p0l1kv6n	64	34	.	.	.
cord-022290-p0l1kv6n	65	1	The	the	DT
cord-022290-p0l1kv6n	65	2	P1	P1	NNP
cord-022290-p0l1kv6n	65	3	residue	residue	NN
cord-022290-p0l1kv6n	65	4	,	,	,
cord-022290-p0l1kv6n	65	5	immediately	immediately	RB
cord-022290-p0l1kv6n	65	6	preceding	precede	VBG
cord-022290-p0l1kv6n	65	7	the	the	DT
cord-022290-p0l1kv6n	65	8	scissile	scissile	NNP
cord-022290-p0l1kv6n	65	9	peptide	peptide	NNP
cord-022290-p0l1kv6n	65	10	bond	bond	NN
cord-022290-p0l1kv6n	65	11	,	,	,
cord-022290-p0l1kv6n	65	12	is	be	VBZ
cord-022290-p0l1kv6n	65	13	almost	almost	RB
cord-022290-p0l1kv6n	65	14	always	always	RB
cord-022290-p0l1kv6n	65	15	a	a	DT
cord-022290-p0l1kv6n	65	16	glutamine	glutamine	NN
cord-022290-p0l1kv6n	65	17	.	.	.
cord-022290-p0l1kv6n	66	1	The	the	DT
cord-022290-p0l1kv6n	66	2	3C	3c	NN
cord-022290-p0l1kv6n	66	3	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	66	4	of	of	IN
cord-022290-p0l1kv6n	66	5	the	the	DT
cord-022290-p0l1kv6n	66	6	individual	individual	JJ
cord-022290-p0l1kv6n	66	7	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	66	8	also	also	RB
cord-022290-p0l1kv6n	66	9	have	have	VBP
cord-022290-p0l1kv6n	66	10	sequence	sequence	NN
cord-022290-p0l1kv6n	66	11	preferences	preference	NNS
cord-022290-p0l1kv6n	66	12	for	for	IN
cord-022290-p0l1kv6n	66	13	the	the	DT
cord-022290-p0l1kv6n	66	14	residues	residue	NNS
cord-022290-p0l1kv6n	66	15	at	at	IN
cord-022290-p0l1kv6n	66	16	the	the	DT
cord-022290-p0l1kv6n	66	17	P4	P4	NNP
cord-022290-p0l1kv6n	66	18	,	,	,
cord-022290-p0l1kv6n	66	19	P2	P2	NNP
cord-022290-p0l1kv6n	66	20	,	,	,
cord-022290-p0l1kv6n	66	21	P~	P~	NNP
cord-022290-p0l1kv6n	66	22	,	,	,
cord-022290-p0l1kv6n	66	23	and	and	CC
cord-022290-p0l1kv6n	66	24	P~	p~	DT
cord-022290-p0l1kv6n	66	25	sites	site	NNS
cord-022290-p0l1kv6n	66	26	of	of	IN
cord-022290-p0l1kv6n	66	27	a	a	DT
cord-022290-p0l1kv6n	66	28	cleavage	cleavage	NN
cord-022290-p0l1kv6n	66	29	site	site	NN
cord-022290-p0l1kv6n	66	30	(	(	-LRB-
cord-022290-p0l1kv6n	66	31	Nicklin	Nicklin	NNP
cord-022290-p0l1kv6n	66	32	et	et	NNP
cord-022290-p0l1kv6n	66	33	al	al	NNP
cord-022290-p0l1kv6n	66	34	.	.	NNP
cord-022290-p0l1kv6n	66	35	,	,	,
cord-022290-p0l1kv6n	66	36	1988	1988	CD
cord-022290-p0l1kv6n	66	37	;	;	:
cord-022290-p0l1kv6n	66	38	Long	long	RB
cord-022290-p0l1kv6n	66	39	et	et	NNP
cord-022290-p0l1kv6n	66	40	al	al	NNP
cord-022290-p0l1kv6n	66	41	.	.	NNP
cord-022290-p0l1kv6n	66	42	,	,	,
cord-022290-p0l1kv6n	66	43	1989	1989	CD
cord-022290-p0l1kv6n	66	44	;	;	:
cord-022290-p0l1kv6n	67	1	Pallai	Pallai	NNP
cord-022290-p0l1kv6n	67	2	et	et	NNP
cord-022290-p0l1kv6n	67	3	al	al	NNP
cord-022290-p0l1kv6n	67	4	.	.	.
cord-022290-p0l1kv6n	68	1	,	,	,
cord-022290-p0l1kv6n	68	2	1989	1989	CD
cord-022290-p0l1kv6n	68	3	;	;	:
cord-022290-p0l1kv6n	68	4	Weidner	Weidner	NNP
cord-022290-p0l1kv6n	68	5	and	and	CC
cord-022290-p0l1kv6n	68	6	Dunn	Dunn	NNP
cord-022290-p0l1kv6n	68	7	,	,	,
cord-022290-p0l1kv6n	68	8	1991	1991	CD
cord-022290-p0l1kv6n	68	9	;	;	:
cord-022290-p0l1kv6n	68	10	Malcolm	Malcolm	NNP
cord-022290-p0l1kv6n	68	11	,	,	,
cord-022290-p0l1kv6n	68	12	1995	1995	CD
cord-022290-p0l1kv6n	68	13	)	)	-RRB-
cord-022290-p0l1kv6n	68	14	.	.	.
cord-022290-p0l1kv6n	69	1	However	however	RB
cord-022290-p0l1kv6n	69	2	,	,	,
cord-022290-p0l1kv6n	69	3	what	what	WP
cord-022290-p0l1kv6n	69	4	distinguishes	distinguish	VBZ
cord-022290-p0l1kv6n	69	5	the	the	DT
cord-022290-p0l1kv6n	69	6	good	good	JJ
cord-022290-p0l1kv6n	69	7	,	,	,
cord-022290-p0l1kv6n	69	8	preferred	preferred	JJ
cord-022290-p0l1kv6n	69	9	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	69	10	sites	site	NNS
cord-022290-p0l1kv6n	69	11	from	from	IN
cord-022290-p0l1kv6n	69	12	the	the	DT
cord-022290-p0l1kv6n	69	13	ones	one	NNS
cord-022290-p0l1kv6n	69	14	that	that	WDT
cord-022290-p0l1kv6n	69	15	are	be	VBP
cord-022290-p0l1kv6n	69	16	cleaved	cleave	VBN
cord-022290-p0l1kv6n	69	17	more	more	RBR
cord-022290-p0l1kv6n	69	18	slowly	slowly	RB
cord-022290-p0l1kv6n	69	19	is	be	VBZ
cord-022290-p0l1kv6n	69	20	not	not	RB
cord-022290-p0l1kv6n	69	21	apparent	apparent	JJ
cord-022290-p0l1kv6n	69	22	from	from	IN
cord-022290-p0l1kv6n	69	23	the	the	DT
cord-022290-p0l1kv6n	69	24	peptide	peptide	NN
cord-022290-p0l1kv6n	69	25	sequence	sequence	NN
cord-022290-p0l1kv6n	69	26	.	.	.
cord-022290-p0l1kv6n	70	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	70	2	is	be	VBZ
cord-022290-p0l1kv6n	70	3	very	very	RB
cord-022290-p0l1kv6n	70	4	likely	likely	JJ
cord-022290-p0l1kv6n	70	5	that	that	IN
cord-022290-p0l1kv6n	70	6	other	other	JJ
cord-022290-p0l1kv6n	70	7	factors	factor	NNS
cord-022290-p0l1kv6n	70	8	,	,	,
cord-022290-p0l1kv6n	70	9	such	such	JJ
cord-022290-p0l1kv6n	70	10	as	as	IN
cord-022290-p0l1kv6n	70	11	the	the	DT
cord-022290-p0l1kv6n	70	12	accessibility	accessibility	NN
cord-022290-p0l1kv6n	70	13	and	and	CC
cord-022290-p0l1kv6n	70	14	the	the	DT
cord-022290-p0l1kv6n	70	15	local	local	JJ
cord-022290-p0l1kv6n	70	16	conformation	conformation	NN
cord-022290-p0l1kv6n	70	17	,	,	,
cord-022290-p0l1kv6n	70	18	play	play	VB
cord-022290-p0l1kv6n	70	19	a	a	DT
cord-022290-p0l1kv6n	70	20	part	part	NN
cord-022290-p0l1kv6n	70	21	in	in	IN
cord-022290-p0l1kv6n	70	22	the	the	DT
cord-022290-p0l1kv6n	70	23	determination	determination	NN
cord-022290-p0l1kv6n	70	24	of	of	IN
cord-022290-p0l1kv6n	70	25	the	the	DT
cord-022290-p0l1kv6n	70	26	sequence	sequence	NN
cord-022290-p0l1kv6n	70	27	of	of	IN
cord-022290-p0l1kv6n	70	28	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	70	29	.	.	.
cord-022290-p0l1kv6n	71	1	The	the	DT
cord-022290-p0l1kv6n	71	2	details	detail	NNS
cord-022290-p0l1kv6n	71	3	of	of	IN
cord-022290-p0l1kv6n	71	4	the	the	DT
cord-022290-p0l1kv6n	71	5	polyprotein	polyprotein	JJ
cord-022290-p0l1kv6n	71	6	processing	processing	NN
cord-022290-p0l1kv6n	71	7	are	be	VBP
cord-022290-p0l1kv6n	71	8	one	one	CD
cord-022290-p0l1kv6n	71	9	factor	factor	NN
cord-022290-p0l1kv6n	71	10	that	that	WDT
cord-022290-p0l1kv6n	71	11	distinguishes	distinguish	VBZ
cord-022290-p0l1kv6n	71	12	the	the	DT
cord-022290-p0l1kv6n	71	13	six	six	CD
cord-022290-p0l1kv6n	71	14	different	different	JJ
cord-022290-p0l1kv6n	71	15	genera	genus	NNS
cord-022290-p0l1kv6n	71	16	of	of	IN
cord-022290-p0l1kv6n	71	17	the	the	DT
cord-022290-p0l1kv6n	71	18	Picornaviridae	Picornaviridae	NNP
cord-022290-p0l1kv6n	71	19	.	.	.
cord-022290-p0l1kv6n	72	1	Only	only	RB
cord-022290-p0l1kv6n	72	2	a	a	DT
cord-022290-p0l1kv6n	72	3	single	single	JJ
cord-022290-p0l1kv6n	72	4	proteinase	proteinase	NN
cord-022290-p0l1kv6n	72	5	,	,	,
cord-022290-p0l1kv6n	72	6	the	the	DT
cord-022290-p0l1kv6n	72	7	3C	3C	NNP
cord-022290-p0l1kv6n	72	8	gene	gene	NN
cord-022290-p0l1kv6n	72	9	product	product	NN
cord-022290-p0l1kv6n	72	10	,	,	,
cord-022290-p0l1kv6n	72	11	is	be	VBZ
cord-022290-p0l1kv6n	72	12	present	present	JJ
cord-022290-p0l1kv6n	72	13	in	in	IN
cord-022290-p0l1kv6n	72	14	the	the	DT
cord-022290-p0l1kv6n	72	15	cardio-	cardio-	NN
cord-022290-p0l1kv6n	72	16	,	,	,
cord-022290-p0l1kv6n	72	17	hepato-	hepato-	NNS
cord-022290-p0l1kv6n	72	18	,	,	,
cord-022290-p0l1kv6n	72	19	and	and	CC
cord-022290-p0l1kv6n	72	20	parechoviruses	parechoviruses	NNP
cord-022290-p0l1kv6n	72	21	.	.	.
cord-022290-p0l1kv6n	73	1	In	in	IN
cord-022290-p0l1kv6n	73	2	the	the	DT
cord-022290-p0l1kv6n	73	3	entero	entero	NNP
cord-022290-p0l1kv6n	73	4	-	-	HYPH
cord-022290-p0l1kv6n	73	5	and	and	CC
cord-022290-p0l1kv6n	73	6	rhinoviruses	rhinovirus	NNS
cord-022290-p0l1kv6n	73	7	the	the	DT
cord-022290-p0l1kv6n	73	8	2A	2a	CD
cord-022290-p0l1kv6n	73	9	gene	gene	NN
cord-022290-p0l1kv6n	73	10	product	product	NN
cord-022290-p0l1kv6n	73	11	is	be	VBZ
cord-022290-p0l1kv6n	73	12	a	a	DT
cord-022290-p0l1kv6n	73	13	second	second	JJ
cord-022290-p0l1kv6n	73	14	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	73	15	enzyme	enzyme	NN
cord-022290-p0l1kv6n	73	16	.	.	.
cord-022290-p0l1kv6n	74	1	An	an	DT
cord-022290-p0l1kv6n	74	2	L	l	NN
cord-022290-p0l1kv6n	74	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	74	4	at	at	IN
cord-022290-p0l1kv6n	74	5	the	the	DT
cord-022290-p0l1kv6n	74	6	amino	amino	NN
cord-022290-p0l1kv6n	74	7	-	-	HYPH
cord-022290-p0l1kv6n	74	8	terminus	terminus	NN
cord-022290-p0l1kv6n	74	9	of	of	IN
cord-022290-p0l1kv6n	74	10	the	the	DT
cord-022290-p0l1kv6n	74	11	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	74	12	is	be	VBZ
cord-022290-p0l1kv6n	74	13	a	a	DT
cord-022290-p0l1kv6n	74	14	unique	unique	JJ
cord-022290-p0l1kv6n	74	15	feature	feature	NN
cord-022290-p0l1kv6n	74	16	of	of	IN
cord-022290-p0l1kv6n	74	17	the	the	DT
cord-022290-p0l1kv6n	74	18	aphthoviruses	aphthoviruse	NNS
cord-022290-p0l1kv6n	74	19	.	.	.
cord-022290-p0l1kv6n	75	1	The	the	DT
cord-022290-p0l1kv6n	75	2	separation	separation	NN
cord-022290-p0l1kv6n	75	3	of	of	IN
cord-022290-p0l1kv6n	75	4	the	the	DT
cord-022290-p0l1kv6n	75	5	structural	structural	JJ
cord-022290-p0l1kv6n	75	6	and	and	CC
cord-022290-p0l1kv6n	75	7	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	75	8	proteins	protein	NNS
cord-022290-p0l1kv6n	75	9	is	be	VBZ
cord-022290-p0l1kv6n	75	10	usually	usually	RB
cord-022290-p0l1kv6n	75	11	the	the	DT
cord-022290-p0l1kv6n	75	12	primary	primary	JJ
cord-022290-p0l1kv6n	75	13	cleavage	cleavage	NN
cord-022290-p0l1kv6n	75	14	event	event	NN
cord-022290-p0l1kv6n	75	15	,	,	,
cord-022290-p0l1kv6n	75	16	but	but	CC
cord-022290-p0l1kv6n	75	17	this	this	DT
cord-022290-p0l1kv6n	75	18	is	be	VBZ
cord-022290-p0l1kv6n	75	19	accomplished	accomplish	VBN
cord-022290-p0l1kv6n	75	20	quite	quite	RB
cord-022290-p0l1kv6n	75	21	differently	differently	RB
cord-022290-p0l1kv6n	75	22	in	in	IN
cord-022290-p0l1kv6n	75	23	the	the	DT
cord-022290-p0l1kv6n	75	24	individual	individual	JJ
cord-022290-p0l1kv6n	75	25	genera	genus	NNS
cord-022290-p0l1kv6n	75	26	.	.	.
cord-022290-p0l1kv6n	76	1	In	in	IN
cord-022290-p0l1kv6n	76	2	enterom	enterom	NN
cord-022290-p0l1kv6n	76	3	and	and	CC
cord-022290-p0l1kv6n	76	4	rhinoviruses	rhinovirus	NNS
cord-022290-p0l1kv6n	76	5	2A	2a	CD
cord-022290-p0l1kv6n	76	6	is	be	VBZ
cord-022290-p0l1kv6n	76	7	a	a	DT
cord-022290-p0l1kv6n	76	8	separate	separate	JJ
cord-022290-p0l1kv6n	76	9	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	76	10	activity	activity	NN
cord-022290-p0l1kv6n	76	11	.	.	.
cord-022290-p0l1kv6n	77	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	77	2	performs	perform	VBZ
cord-022290-p0l1kv6n	77	3	the	the	DT
cord-022290-p0l1kv6n	77	4	primary	primary	JJ
cord-022290-p0l1kv6n	77	5	cleavage	cleavage	NN
cord-022290-p0l1kv6n	77	6	at	at	IN
cord-022290-p0l1kv6n	77	7	its	-PRON-	PRP$
cord-022290-p0l1kv6n	77	8	own	own	JJ
cord-022290-p0l1kv6n	77	9	amino	amino	NN
cord-022290-p0l1kv6n	77	10	-	-	HYPH
cord-022290-p0l1kv6n	77	11	terminus	terminus	NN
cord-022290-p0l1kv6n	77	12	which	which	WDT
cord-022290-p0l1kv6n	77	13	separates	separate	VBZ
cord-022290-p0l1kv6n	77	14	P	p	NN
cord-022290-p0l1kv6n	77	15	1	1	CD
cord-022290-p0l1kv6n	77	16	from	from	IN
cord-022290-p0l1kv6n	77	17	the	the	DT
cord-022290-p0l1kv6n	77	18	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	77	19	proteins	protein	NNS
cord-022290-p0l1kv6n	77	20	.	.	.
cord-022290-p0l1kv6n	78	1	In	in	IN
cord-022290-p0l1kv6n	78	2	the	the	DT
cord-022290-p0l1kv6n	78	3	hepatom	hepatom	NN
cord-022290-p0l1kv6n	78	4	and	and	CC
cord-022290-p0l1kv6n	78	5	parechoviruses	parechoviruses	NNP
cord-022290-p0l1kv6n	78	6	the	the	DT
cord-022290-p0l1kv6n	78	7	primary	primary	JJ
cord-022290-p0l1kv6n	78	8	cleavage	cleavage	NN
cord-022290-p0l1kv6n	78	9	is	be	VBZ
cord-022290-p0l1kv6n	78	10	a	a	DT
cord-022290-p0l1kv6n	78	11	3C	3c	NN
cord-022290-p0l1kv6n	78	12	-	-	HYPH
cord-022290-p0l1kv6n	78	13	mediated	mediate	VBN
cord-022290-p0l1kv6n	78	14	cleavage	cleavage	NN
cord-022290-p0l1kv6n	78	15	at	at	IN
cord-022290-p0l1kv6n	78	16	the	the	DT
cord-022290-p0l1kv6n	78	17	amino	amino	NN
cord-022290-p0l1kv6n	78	18	-	-	HYPH
cord-022290-p0l1kv6n	78	19	terminus	terminus	NN
cord-022290-p0l1kv6n	78	20	of	of	IN
cord-022290-p0l1kv6n	78	21	the	the	DT
cord-022290-p0l1kv6n	78	22	2B	2B	NNP
cord-022290-p0l1kv6n	78	23	gene	gene	NN
cord-022290-p0l1kv6n	78	24	product	product	NN
cord-022290-p0l1kv6n	79	1	(	(	-LRB-
cord-022290-p0l1kv6n	79	2	Jia	Jia	NNP
cord-022290-p0l1kv6n	79	3	et	et	NNP
cord-022290-p0l1kv6n	79	4	al	al	NNP
cord-022290-p0l1kv6n	79	5	.	.	NNP
cord-022290-p0l1kv6n	79	6	,	,	,
cord-022290-p0l1kv6n	79	7	1993	1993	CD
cord-022290-p0l1kv6n	79	8	;	;	:
cord-022290-p0l1kv6n	79	9	Schultheiss	Schultheiss	NNP
cord-022290-p0l1kv6n	79	10	et	et	FW
cord-022290-p0l1kv6n	79	11	al	al	NNP
cord-022290-p0l1kv6n	79	12	.	.	NNP
cord-022290-p0l1kv6n	79	13	,	,	,
cord-022290-p0l1kv6n	79	14	1994	1994	CD
cord-022290-p0l1kv6n	79	15	;	;	:
cord-022290-p0l1kv6n	79	16	Martin	Martin	NNP
cord-022290-p0l1kv6n	79	17	et	et	NNP
cord-022290-p0l1kv6n	79	18	al	al	NNP
cord-022290-p0l1kv6n	79	19	.	.	NNP
cord-022290-p0l1kv6n	79	20	,	,	,
cord-022290-p0l1kv6n	79	21	1995	1995	CD
cord-022290-p0l1kv6n	79	22	;	;	:
cord-022290-p0l1kv6n	79	23	Schultheiss	Schultheiss	NNP
cord-022290-p0l1kv6n	79	24	et	et	FW
cord-022290-p0l1kv6n	79	25	al	al	NNP
cord-022290-p0l1kv6n	79	26	.	.	NNP
cord-022290-p0l1kv6n	79	27	,	,	,
cord-022290-p0l1kv6n	79	28	1995a	1995a	CD
cord-022290-p0l1kv6n	79	29	)	)	-RRB-
cord-022290-p0l1kv6n	79	30	.	.	.
cord-022290-p0l1kv6n	80	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	80	2	is	be	VBZ
cord-022290-p0l1kv6n	80	3	not	not	RB
cord-022290-p0l1kv6n	80	4	clear	clear	JJ
cord-022290-p0l1kv6n	80	5	if	if	IN
cord-022290-p0l1kv6n	80	6	the	the	DT
cord-022290-p0l1kv6n	80	7	small	small	JJ
cord-022290-p0l1kv6n	80	8	2A	2a	CD
cord-022290-p0l1kv6n	80	9	gene	gene	NN
cord-022290-p0l1kv6n	80	10	product	product	NN
cord-022290-p0l1kv6n	80	11	has	have	VBZ
cord-022290-p0l1kv6n	80	12	any	any	DT
cord-022290-p0l1kv6n	80	13	function	function	NN
cord-022290-p0l1kv6n	80	14	.	.	.
cord-022290-p0l1kv6n	81	1	In	in	IN
cord-022290-p0l1kv6n	81	2	the	the	DT
cord-022290-p0l1kv6n	81	3	aphtho	aphtho	NNP
cord-022290-p0l1kv6n	81	4	-	-	HYPH
cord-022290-p0l1kv6n	81	5	and	and	CC
cord-022290-p0l1kv6n	81	6	cardioviruses	cardioviruse	VBZ
cord-022290-p0l1kv6n	81	7	the	the	DT
cord-022290-p0l1kv6n	81	8	primary	primary	JJ
cord-022290-p0l1kv6n	81	9	cleavage	cleavage	NN
cord-022290-p0l1kv6n	81	10	is	be	VBZ
cord-022290-p0l1kv6n	81	11	at	at	IN
cord-022290-p0l1kv6n	81	12	the	the	DT
cord-022290-p0l1kv6n	81	13	carboxy	carboxy	JJ
cord-022290-p0l1kv6n	81	14	-	-	HYPH
cord-022290-p0l1kv6n	81	15	terminus	terminus	NN
cord-022290-p0l1kv6n	81	16	of	of	IN
cord-022290-p0l1kv6n	81	17	2A.	2a.	CD
cord-022290-p0l1kv6n	82	1	The	the	DT
cord-022290-p0l1kv6n	82	2	2A	2a	CD
cord-022290-p0l1kv6n	82	3	gene	gene	NN
cord-022290-p0l1kv6n	82	4	product	product	NN
cord-022290-p0l1kv6n	82	5	is	be	VBZ
cord-022290-p0l1kv6n	82	6	not	not	RB
cord-022290-p0l1kv6n	82	7	a	a	DT
cord-022290-p0l1kv6n	82	8	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	82	9	enzyme	enzyme	NN
cord-022290-p0l1kv6n	82	10	in	in	IN
cord-022290-p0l1kv6n	82	11	these	these	DT
cord-022290-p0l1kv6n	82	12	viruses	virus	NNS
cord-022290-p0l1kv6n	82	13	.	.	.
cord-022290-p0l1kv6n	83	1	The	the	DT
cord-022290-p0l1kv6n	83	2	cleavage	cleavage	NN
cord-022290-p0l1kv6n	83	3	is	be	VBZ
cord-022290-p0l1kv6n	83	4	presumably	presumably	RB
cord-022290-p0l1kv6n	83	5	nonenzymatic	nonenzymatic	JJ
cord-022290-p0l1kv6n	83	6	and	and	CC
cord-022290-p0l1kv6n	83	7	requires	require	VBZ
cord-022290-p0l1kv6n	83	8	the	the	DT
cord-022290-p0l1kv6n	83	9	carboxy	carboxy	JJ
cord-022290-p0l1kv6n	83	10	-	-	HYPH
cord-022290-p0l1kv6n	83	11	terminal	terminal	NN
cord-022290-p0l1kv6n	83	12	residues	residue	NNS
cord-022290-p0l1kv6n	83	13	of	of	IN
cord-022290-p0l1kv6n	83	14	2A	2a	CD
cord-022290-p0l1kv6n	84	1	(	(	-LRB-
cord-022290-p0l1kv6n	84	2	Palmenberg	Palmenberg	NNP
cord-022290-p0l1kv6n	84	3	et	et	NNP
cord-022290-p0l1kv6n	84	4	al	al	NNP
cord-022290-p0l1kv6n	84	5	.	.	NNP
cord-022290-p0l1kv6n	84	6	,	,	,
cord-022290-p0l1kv6n	84	7	1992	1992	CD
cord-022290-p0l1kv6n	84	8	;	;	:
cord-022290-p0l1kv6n	84	9	Donnelly	Donnelly	NNP
cord-022290-p0l1kv6n	84	10	et	et	NNP
cord-022290-p0l1kv6n	84	11	al	al	NNP
cord-022290-p0l1kv6n	84	12	.	.	NNP
cord-022290-p0l1kv6n	84	13	,	,	,
cord-022290-p0l1kv6n	84	14	1997	1997	CD
cord-022290-p0l1kv6n	84	15	)	)	-RRB-
cord-022290-p0l1kv6n	84	16	.	.	.
cord-022290-p0l1kv6n	85	1	The	the	DT
cord-022290-p0l1kv6n	85	2	second	second	JJ
cord-022290-p0l1kv6n	85	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	85	4	present	present	NN
cord-022290-p0l1kv6n	85	5	in	in	IN
cord-022290-p0l1kv6n	85	6	the	the	DT
cord-022290-p0l1kv6n	85	7	aphthoviruses	aphthoviruse	NNS
cord-022290-p0l1kv6n	85	8	,	,	,
cord-022290-p0l1kv6n	85	9	the	the	DT
cord-022290-p0l1kv6n	85	10	L	L	NNP
cord-022290-p0l1kv6n	85	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	85	12	,	,	,
cord-022290-p0l1kv6n	85	13	only	only	RB
cord-022290-p0l1kv6n	85	14	cleaves	cleave	VBZ
cord-022290-p0l1kv6n	85	15	itself	-PRON-	PRP
cord-022290-p0l1kv6n	85	16	from	from	IN
cord-022290-p0l1kv6n	85	17	the	the	DT
cord-022290-p0l1kv6n	85	18	amino	amino	NN
cord-022290-p0l1kv6n	85	19	-	-	HYPH
cord-022290-p0l1kv6n	85	20	terminus	terminus	NN
cord-022290-p0l1kv6n	85	21	of	of	IN
cord-022290-p0l1kv6n	85	22	the	the	DT
cord-022290-p0l1kv6n	85	23	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	85	24	(	(	-LRB-
cord-022290-p0l1kv6n	85	25	Strebel	Strebel	NNP
cord-022290-p0l1kv6n	85	26	and	and	CC
cord-022290-p0l1kv6n	85	27	Beck	Beck	NNP
cord-022290-p0l1kv6n	85	28	,	,	,
cord-022290-p0l1kv6n	85	29	1986	1986	CD
cord-022290-p0l1kv6n	85	30	)	)	-RRB-
cord-022290-p0l1kv6n	85	31	.	.	.
cord-022290-p0l1kv6n	86	1	Larger	large	JJR
cord-022290-p0l1kv6n	86	2	precursors	precursor	NNS
cord-022290-p0l1kv6n	86	3	of	of	IN
cord-022290-p0l1kv6n	86	4	the	the	DT
cord-022290-p0l1kv6n	86	5	3C	3C	NNP
cord-022290-p0l1kv6n	86	6	proteinase	proteinase	NN
cord-022290-p0l1kv6n	86	7	,	,	,
cord-022290-p0l1kv6n	86	8	such	such	JJ
cord-022290-p0l1kv6n	86	9	as	as	IN
cord-022290-p0l1kv6n	86	10	3CD	3cd	CD
cord-022290-p0l1kv6n	86	11	or	or	CC
cord-022290-p0l1kv6n	86	12	3ABC	3abc	NN
cord-022290-p0l1kv6n	86	13	are	be	VBP
cord-022290-p0l1kv6n	86	14	also	also	RB
cord-022290-p0l1kv6n	86	15	catalytically	catalytically	RB
cord-022290-p0l1kv6n	86	16	active	active	JJ
cord-022290-p0l1kv6n	86	17	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	87	1	(	(	-LRB-
cord-022290-p0l1kv6n	87	2	Ypma	Ypma	NNP
cord-022290-p0l1kv6n	87	3	-	-	HYPH
cord-022290-p0l1kv6n	87	4	Wong	Wong	NNP
cord-022290-p0l1kv6n	87	5	et	et	NNP
cord-022290-p0l1kv6n	87	6	al	al	NNP
cord-022290-p0l1kv6n	87	7	.	.	NNP
cord-022290-p0l1kv6n	87	8	,	,	,
cord-022290-p0l1kv6n	87	9	1988	1988	CD
cord-022290-p0l1kv6n	87	10	;	;	.
cord-022290-p0l1kv6n	88	1	Harris	Harris	NNP
cord-022290-p0l1kv6n	88	2	et	et	NNP
cord-022290-p0l1kv6n	88	3	al	al	NNP
cord-022290-p0l1kv6n	88	4	.	.	.
cord-022290-p0l1kv6n	89	1	,	,	,
cord-022290-p0l1kv6n	89	2	1992	1992	CD
cord-022290-p0l1kv6n	89	3	;	;	:
cord-022290-p0l1kv6n	89	4	Davis	Davis	NNP
cord-022290-p0l1kv6n	89	5	et	et	NNP
cord-022290-p0l1kv6n	89	6	al	al	NNP
cord-022290-p0l1kv6n	89	7	.	.	NNP
cord-022290-p0l1kv6n	89	8	,	,	,
cord-022290-p0l1kv6n	89	9	1997	1997	CD
cord-022290-p0l1kv6n	89	10	)	)	-RRB-
cord-022290-p0l1kv6n	89	11	.	.	.
cord-022290-p0l1kv6n	90	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	90	2	has	have	VBZ
cord-022290-p0l1kv6n	90	3	been	be	VBN
cord-022290-p0l1kv6n	90	4	shown	show	VBN
cord-022290-p0l1kv6n	90	5	in	in	IN
cord-022290-p0l1kv6n	90	6	some	some	DT
cord-022290-p0l1kv6n	90	7	systems	system	NNS
cord-022290-p0l1kv6n	90	8	that	that	WDT
cord-022290-p0l1kv6n	90	9	the	the	DT
cord-022290-p0l1kv6n	90	10	presence	presence	NN
cord-022290-p0l1kv6n	90	11	of	of	IN
cord-022290-p0l1kv6n	90	12	an	an	DT
cord-022290-p0l1kv6n	90	13	additional	additional	JJ
cord-022290-p0l1kv6n	90	14	domain	domain	NN
cord-022290-p0l1kv6n	90	15	can	can	MD
cord-022290-p0l1kv6n	90	16	change	change	VB
cord-022290-p0l1kv6n	90	17	the	the	DT
cord-022290-p0l1kv6n	90	18	efficiency	efficiency	NN
cord-022290-p0l1kv6n	90	19	and	and	CC
cord-022290-p0l1kv6n	90	20	specificity	specificity	NN
cord-022290-p0l1kv6n	90	21	of	of	IN
cord-022290-p0l1kv6n	90	22	the	the	DT
cord-022290-p0l1kv6n	90	23	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	90	24	activity	activity	NN
cord-022290-p0l1kv6n	90	25	.	.	.
cord-022290-p0l1kv6n	91	1	In	in	IN
cord-022290-p0l1kv6n	91	2	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	91	3	,	,	,
cord-022290-p0l1kv6n	91	4	3CD	3CD	NNP
cord-022290-p0l1kv6n	91	5	is	be	VBZ
cord-022290-p0l1kv6n	91	6	a	a	DT
cord-022290-p0l1kv6n	91	7	proteinase	proteinase	NN
cord-022290-p0l1kv6n	91	8	with	with	IN
cord-022290-p0l1kv6n	91	9	a	a	DT
cord-022290-p0l1kv6n	91	10	distinct	distinct	JJ
cord-022290-p0l1kv6n	91	11	specificity	specificity	NN
cord-022290-p0l1kv6n	91	12	(	(	-LRB-
cord-022290-p0l1kv6n	91	13	Ypma	Ypma	NNP
cord-022290-p0l1kv6n	91	14	-	-	HYPH
cord-022290-p0l1kv6n	91	15	Wong	Wong	NNP
cord-022290-p0l1kv6n	91	16	et	et	NNP
cord-022290-p0l1kv6n	91	17	al	al	NNP
cord-022290-p0l1kv6n	91	18	.	.	NNP
cord-022290-p0l1kv6n	91	19	,	,	,
cord-022290-p0l1kv6n	91	20	1988	1988	CD
cord-022290-p0l1kv6n	91	21	)	)	-RRB-
cord-022290-p0l1kv6n	91	22	.	.	.
cord-022290-p0l1kv6n	92	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	92	2	cleaves	cleave	VBZ
cord-022290-p0l1kv6n	92	3	at	at	IN
cord-022290-p0l1kv6n	92	4	least	least	JJS
cord-022290-p0l1kv6n	92	5	some	some	DT
cord-022290-p0l1kv6n	92	6	of	of	IN
cord-022290-p0l1kv6n	92	7	the	the	DT
cord-022290-p0l1kv6n	92	8	cleavage	cleavage	NN
cord-022290-p0l1kv6n	92	9	sites	site	NNS
cord-022290-p0l1kv6n	92	10	within	within	IN
cord-022290-p0l1kv6n	92	11	the	the	DT
cord-022290-p0l1kv6n	92	12	viral	viral	JJ
cord-022290-p0l1kv6n	92	13	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	92	14	more	more	RBR
cord-022290-p0l1kv6n	92	15	efficiently	efficiently	RB
cord-022290-p0l1kv6n	92	16	and	and	CC
cord-022290-p0l1kv6n	92	17	is	be	VBZ
cord-022290-p0l1kv6n	92	18	presumably	presumably	RB
cord-022290-p0l1kv6n	92	19	required	require	VBN
cord-022290-p0l1kv6n	92	20	for	for	IN
cord-022290-p0l1kv6n	92	21	the	the	DT
cord-022290-p0l1kv6n	92	22	processing	processing	NN
cord-022290-p0l1kv6n	92	23	of	of	IN
cord-022290-p0l1kv6n	92	24	the	the	DT
cord-022290-p0l1kv6n	92	25	cleavage	cleavage	NN
cord-022290-p0l1kv6n	92	26	sites	site	NNS
cord-022290-p0l1kv6n	92	27	within	within	IN
cord-022290-p0l1kv6n	92	28	the	the	DT
cord-022290-p0l1kv6n	92	29	structural	structural	JJ
cord-022290-p0l1kv6n	92	30	protein	protein	NN
cord-022290-p0l1kv6n	92	31	.	.	.
cord-022290-p0l1kv6n	93	1	In	in	IN
cord-022290-p0l1kv6n	93	2	other	other	JJ
cord-022290-p0l1kv6n	93	3	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	93	4	other	other	JJ
cord-022290-p0l1kv6n	93	5	precursors	precursor	NNS
cord-022290-p0l1kv6n	93	6	may	may	MD
cord-022290-p0l1kv6n	93	7	play	play	VB
cord-022290-p0l1kv6n	93	8	a	a	DT
cord-022290-p0l1kv6n	93	9	similar	similar	JJ
cord-022290-p0l1kv6n	93	10	role	role	NN
cord-022290-p0l1kv6n	93	11	.	.	.
cord-022290-p0l1kv6n	94	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	94	2	has	have	VBZ
cord-022290-p0l1kv6n	94	3	been	be	VBN
cord-022290-p0l1kv6n	94	4	suggested	suggest	VBN
cord-022290-p0l1kv6n	94	5	that	that	IN
cord-022290-p0l1kv6n	94	6	3ABC	3abc	NN
cord-022290-p0l1kv6n	94	7	is	be	VBZ
cord-022290-p0l1kv6n	94	8	a	a	DT
cord-022290-p0l1kv6n	94	9	proteolytically	proteolytically	RB
cord-022290-p0l1kv6n	94	10	active	active	JJ
cord-022290-p0l1kv6n	94	11	precursor	precursor	NN
cord-022290-p0l1kv6n	94	12	of	of	IN
cord-022290-p0l1kv6n	94	13	3C	3c	NN
cord-022290-p0l1kv6n	94	14	in	in	IN
cord-022290-p0l1kv6n	94	15	HAV	HAV	NNP
cord-022290-p0l1kv6n	95	1	(	(	-LRB-
cord-022290-p0l1kv6n	95	2	Harmon	Harmon	NNP
cord-022290-p0l1kv6n	95	3	et	et	NNP
cord-022290-p0l1kv6n	95	4	al	al	NNP
cord-022290-p0l1kv6n	95	5	.	.	.
cord-022290-p0l1kv6n	96	1	,	,	,
cord-022290-p0l1kv6n	96	2	1992	1992	CD
cord-022290-p0l1kv6n	96	3	;	;	:
cord-022290-p0l1kv6n	96	4	Schultheiss	Schultheiss	NNP
cord-022290-p0l1kv6n	96	5	et	et	FW
cord-022290-p0l1kv6n	96	6	al	al	NNP
cord-022290-p0l1kv6n	96	7	.	.	NNP
cord-022290-p0l1kv6n	96	8	,	,	,
cord-022290-p0l1kv6n	96	9	1994	1994	CD
cord-022290-p0l1kv6n	96	10	)	)	-RRB-
cord-022290-p0l1kv6n	96	11	.	.	.
cord-022290-p0l1kv6n	97	1	Structural	structural	JJ
cord-022290-p0l1kv6n	97	2	proteins	protein	NNS
cord-022290-p0l1kv6n	97	3	of	of	IN
cord-022290-p0l1kv6n	97	4	viruses	virus	NNS
cord-022290-p0l1kv6n	97	5	in	in	IN
cord-022290-p0l1kv6n	97	6	general	general	JJ
cord-022290-p0l1kv6n	97	7	are	be	VBP
cord-022290-p0l1kv6n	97	8	designed	design	VBN
cord-022290-p0l1kv6n	97	9	to	to	TO
cord-022290-p0l1kv6n	97	10	form	form	VB
cord-022290-p0l1kv6n	97	11	large	large	JJ
cord-022290-p0l1kv6n	97	12	assemblies	assembly	NNS
cord-022290-p0l1kv6n	97	13	,	,	,
cord-022290-p0l1kv6n	97	14	such	such	JJ
cord-022290-p0l1kv6n	97	15	as	as	IN
cord-022290-p0l1kv6n	97	16	viral	viral	JJ
cord-022290-p0l1kv6n	97	17	capsids	capsid	NNS
cord-022290-p0l1kv6n	97	18	.	.	.
cord-022290-p0l1kv6n	98	1	Therefore	therefore	RB
cord-022290-p0l1kv6n	98	2	,	,	,
cord-022290-p0l1kv6n	98	3	they	-PRON-	PRP
cord-022290-p0l1kv6n	98	4	have	have	VBP
cord-022290-p0l1kv6n	98	5	to	to	TO
cord-022290-p0l1kv6n	98	6	be	be	VB
cord-022290-p0l1kv6n	98	7	synthesized	synthesize	VBN
cord-022290-p0l1kv6n	98	8	as	as	IN
cord-022290-p0l1kv6n	98	9	precursors	precursor	NNS
cord-022290-p0l1kv6n	98	10	,	,	,
cord-022290-p0l1kv6n	98	11	which	which	WDT
cord-022290-p0l1kv6n	98	12	are	be	VBP
cord-022290-p0l1kv6n	98	13	covalently	covalently	RB
cord-022290-p0l1kv6n	98	14	modified	modify	VBN
cord-022290-p0l1kv6n	98	15	before	before	IN
cord-022290-p0l1kv6n	98	16	they	-PRON-	PRP
cord-022290-p0l1kv6n	98	17	can	can	MD
cord-022290-p0l1kv6n	98	18	assemble	assemble	VB
cord-022290-p0l1kv6n	98	19	.	.	.
cord-022290-p0l1kv6n	99	1	One	one	CD
cord-022290-p0l1kv6n	99	2	very	very	RB
cord-022290-p0l1kv6n	99	3	common	common	JJ
cord-022290-p0l1kv6n	99	4	form	form	NN
cord-022290-p0l1kv6n	99	5	of	of	IN
cord-022290-p0l1kv6n	99	6	modification	modification	NN
cord-022290-p0l1kv6n	99	7	,	,	,
cord-022290-p0l1kv6n	99	8	not	not	RB
cord-022290-p0l1kv6n	99	9	only	only	RB
cord-022290-p0l1kv6n	99	10	in	in	IN
cord-022290-p0l1kv6n	99	11	small	small	JJ
cord-022290-p0l1kv6n	99	12	+	+	CC
cord-022290-p0l1kv6n	99	13	RNA	rna	NN
cord-022290-p0l1kv6n	99	14	viruses	virus	NNS
cord-022290-p0l1kv6n	99	15	,	,	,
cord-022290-p0l1kv6n	99	16	is	be	VBZ
cord-022290-p0l1kv6n	99	17	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	99	18	processing	processing	NN
cord-022290-p0l1kv6n	99	19	of	of	IN
cord-022290-p0l1kv6n	99	20	the	the	DT
cord-022290-p0l1kv6n	99	21	precursor	precursor	NN
cord-022290-p0l1kv6n	99	22	(	(	-LRB-
cord-022290-p0l1kv6n	99	23	Kay	Kay	NNP
cord-022290-p0l1kv6n	99	24	and	and	CC
cord-022290-p0l1kv6n	99	25	Dunn	Dunn	NNP
cord-022290-p0l1kv6n	99	26	,	,	,
cord-022290-p0l1kv6n	99	27	1990	1990	CD
cord-022290-p0l1kv6n	99	28	)	)	-RRB-
cord-022290-p0l1kv6n	99	29	.	.	.
cord-022290-p0l1kv6n	100	1	This	this	DT
cord-022290-p0l1kv6n	100	2	is	be	VBZ
cord-022290-p0l1kv6n	100	3	one	one	CD
cord-022290-p0l1kv6n	100	4	reason	reason	NN
cord-022290-p0l1kv6n	100	5	why	why	WRB
cord-022290-p0l1kv6n	100	6	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	100	7	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	100	8	are	be	VBP
cord-022290-p0l1kv6n	100	9	among	among	IN
cord-022290-p0l1kv6n	100	10	the	the	DT
cord-022290-p0l1kv6n	100	11	most	most	RBS
cord-022290-p0l1kv6n	100	12	ubiquitous	ubiquitous	JJ
cord-022290-p0l1kv6n	100	13	enzymatic	enzymatic	JJ
cord-022290-p0l1kv6n	100	14	activities	activity	NNS
cord-022290-p0l1kv6n	100	15	expressed	express	VBN
cord-022290-p0l1kv6n	100	16	by	by	IN
cord-022290-p0l1kv6n	100	17	viruses	virus	NNS
cord-022290-p0l1kv6n	100	18	(	(	-LRB-
cord-022290-p0l1kv6n	100	19	Dougherty	Dougherty	NNP
cord-022290-p0l1kv6n	100	20	and	and	CC
cord-022290-p0l1kv6n	100	21	Semler	Semler	NNP
cord-022290-p0l1kv6n	100	22	,	,	,
cord-022290-p0l1kv6n	100	23	1993	1993	CD
cord-022290-p0l1kv6n	100	24	)	)	-RRB-
cord-022290-p0l1kv6n	100	25	.	.	.
cord-022290-p0l1kv6n	101	1	In	in	IN
cord-022290-p0l1kv6n	101	2	the	the	DT
cord-022290-p0l1kv6n	101	3	Picornaviruses	Picornaviruses	NNP
cord-022290-p0l1kv6n	101	4	the	the	DT
cord-022290-p0l1kv6n	101	5	structural	structural	JJ
cord-022290-p0l1kv6n	101	6	proteins	protein	NNS
cord-022290-p0l1kv6n	101	7	are	be	VBP
cord-022290-p0l1kv6n	101	8	further	further	RB
cord-022290-p0l1kv6n	101	9	proteolytically	proteolytically	RB
cord-022290-p0l1kv6n	101	10	proJ	proj	ADD
cord-022290-p0l1kv6n	101	11	cessed	cesse	VBN
cord-022290-p0l1kv6n	101	12	after	after	IN
cord-022290-p0l1kv6n	101	13	they	-PRON-	PRP
cord-022290-p0l1kv6n	101	14	are	be	VBP
cord-022290-p0l1kv6n	101	15	separated	separate	VBN
cord-022290-p0l1kv6n	101	16	from	from	IN
cord-022290-p0l1kv6n	101	17	the	the	DT
cord-022290-p0l1kv6n	101	18	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	101	19	proteins	protein	NNS
cord-022290-p0l1kv6n	101	20	.	.	.
cord-022290-p0l1kv6n	102	1	Two	two	CD
cord-022290-p0l1kv6n	102	2	sequenJ	sequenJ	NNP
cord-022290-p0l1kv6n	102	3	tial	tial	JJ
cord-022290-p0l1kv6n	102	4	,	,	,
cord-022290-p0l1kv6n	102	5	3C	3c	NN
cord-022290-p0l1kv6n	102	6	-	-	HYPH
cord-022290-p0l1kv6n	102	7	mediated	mediate	VBN
cord-022290-p0l1kv6n	102	8	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	102	9	are	be	VBP
cord-022290-p0l1kv6n	102	10	required	require	VBN
cord-022290-p0l1kv6n	102	11	within	within	IN
cord-022290-p0l1kv6n	102	12	the	the	DT
cord-022290-p0l1kv6n	102	13	capsid	capsid	JJ
cord-022290-p0l1kv6n	102	14	protein	protein	NN
cord-022290-p0l1kv6n	102	15	before	before	IN
cord-022290-p0l1kv6n	102	16	the	the	DT
cord-022290-p0l1kv6n	102	17	resulting	result	VBG
cord-022290-p0l1kv6n	102	18	5S	5S	NNP
cord-022290-p0l1kv6n	102	19	protomers	protomer	NNS
cord-022290-p0l1kv6n	102	20	can	can	MD
cord-022290-p0l1kv6n	102	21	assemble	assemble	VB
cord-022290-p0l1kv6n	102	22	into	into	IN
cord-022290-p0l1kv6n	102	23	larger	large	JJR
cord-022290-p0l1kv6n	102	24	(	(	-LRB-
cord-022290-p0l1kv6n	102	25	14S	14S	NNP
cord-022290-p0l1kv6n	102	26	)	)	-RRB-
cord-022290-p0l1kv6n	102	27	pentamers	pentamer	NNS
cord-022290-p0l1kv6n	102	28	(	(	-LRB-
cord-022290-p0l1kv6n	102	29	Fig	Fig	NNP
cord-022290-p0l1kv6n	102	30	.	.	NNP
cord-022290-p0l1kv6n	102	31	1	1	CD
cord-022290-p0l1kv6n	102	32	)	)	-RRB-
cord-022290-p0l1kv6n	102	33	.	.	.
cord-022290-p0l1kv6n	103	1	Final	final	JJ
cord-022290-p0l1kv6n	103	2	capsid	capsid	NN
cord-022290-p0l1kv6n	103	3	assembly	assembly	NN
cord-022290-p0l1kv6n	103	4	then	then	RB
cord-022290-p0l1kv6n	103	5	requires	require	VBZ
cord-022290-p0l1kv6n	103	6	the	the	DT
cord-022290-p0l1kv6n	103	7	presence	presence	NN
cord-022290-p0l1kv6n	103	8	of	of	IN
cord-022290-p0l1kv6n	103	9	RNA	RNA	NNP
cord-022290-p0l1kv6n	103	10	.	.	.
cord-022290-p0l1kv6n	104	1	In	in	IN
cord-022290-p0l1kv6n	104	2	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	104	3	the	the	DT
cord-022290-p0l1kv6n	104	4	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	104	5	of	of	IN
cord-022290-p0l1kv6n	104	6	the	the	DT
cord-022290-p0l1kv6n	104	7	capsid	capsid	NN
cord-022290-p0l1kv6n	104	8	proteins	protein	NNS
cord-022290-p0l1kv6n	104	9	within	within	IN
cord-022290-p0l1kv6n	104	10	the	the	DT
cord-022290-p0l1kv6n	104	11	protomer	protomer	NN
cord-022290-p0l1kv6n	104	12	require	require	VBP
cord-022290-p0l1kv6n	104	13	the	the	DT
cord-022290-p0l1kv6n	104	14	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	104	15	activity	activity	NN
cord-022290-p0l1kv6n	104	16	of	of	IN
cord-022290-p0l1kv6n	104	17	the	the	DT
cord-022290-p0l1kv6n	104	18	precursor	precursor	NN
cord-022290-p0l1kv6n	104	19	3CD	3cd	CD
cord-022290-p0l1kv6n	105	1	(	(	-LRB-
cord-022290-p0l1kv6n	105	2	Ypma	Ypma	NNP
cord-022290-p0l1kv6n	105	3	-	-	HYPH
cord-022290-p0l1kv6n	105	4	Wong	Wong	NNP
cord-022290-p0l1kv6n	105	5	et	et	NNP
cord-022290-p0l1kv6n	105	6	al	al	NNP
cord-022290-p0l1kv6n	105	7	.	.	NNP
cord-022290-p0l1kv6n	105	8	,	,	,
cord-022290-p0l1kv6n	105	9	1988	1988	CD
cord-022290-p0l1kv6n	105	10	)	)	-RRB-
cord-022290-p0l1kv6n	105	11	.	.	.
cord-022290-p0l1kv6n	106	1	The	the	DT
cord-022290-p0l1kv6n	106	2	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	106	3	3C	3C	NNP
cord-022290-p0l1kv6n	106	4	proteinase	proteinase	NN
cord-022290-p0l1kv6n	106	5	cleaves	cleave	VBZ
cord-022290-p0l1kv6n	106	6	itself	-PRON-	PRP
cord-022290-p0l1kv6n	106	7	out	out	IN
cord-022290-p0l1kv6n	106	8	of	of	IN
cord-022290-p0l1kv6n	106	9	the	the	DT
cord-022290-p0l1kv6n	106	10	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	106	11	.	.	.
cord-022290-p0l1kv6n	107	1	In	in	IN
cord-022290-p0l1kv6n	107	2	experimental	experimental	JJ
cord-022290-p0l1kv6n	107	3	systems	system	NNS
cord-022290-p0l1kv6n	107	4	it	-PRON-	PRP
cord-022290-p0l1kv6n	107	5	was	be	VBD
cord-022290-p0l1kv6n	107	6	shown	show	VBN
cord-022290-p0l1kv6n	107	7	that	that	IN
cord-022290-p0l1kv6n	107	8	this	this	DT
cord-022290-p0l1kv6n	107	9	can	can	MD
cord-022290-p0l1kv6n	107	10	be	be	VB
cord-022290-p0l1kv6n	107	11	accomplished	accomplish	VBN
cord-022290-p0l1kv6n	107	12	both	both	CC
cord-022290-p0l1kv6n	107	13	in	in	IN
cord-022290-p0l1kv6n	107	14	cis	cis	NNP
cord-022290-p0l1kv6n	107	15	,	,	,
cord-022290-p0l1kv6n	107	16	when	when	WRB
cord-022290-p0l1kv6n	107	17	3C	3C	NNP
cord-022290-p0l1kv6n	107	18	is	be	VBZ
cord-022290-p0l1kv6n	107	19	expressed	express	VBN
cord-022290-p0l1kv6n	107	20	as	as	IN
cord-022290-p0l1kv6n	107	21	part	part	NN
cord-022290-p0l1kv6n	107	22	of	of	IN
cord-022290-p0l1kv6n	107	23	the	the	DT
cord-022290-p0l1kv6n	107	24	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	107	25	,	,	,
cord-022290-p0l1kv6n	107	26	or	or	CC
cord-022290-p0l1kv6n	107	27	in	in	IN
cord-022290-p0l1kv6n	107	28	trans	trans	NNP
cord-022290-p0l1kv6n	107	29	,	,	,
cord-022290-p0l1kv6n	107	30	when	when	WRB
cord-022290-p0l1kv6n	107	31	3C	3C	NNP
cord-022290-p0l1kv6n	107	32	is	be	VBZ
cord-022290-p0l1kv6n	107	33	expressed	express	VBN
cord-022290-p0l1kv6n	107	34	separately	separately	RB
cord-022290-p0l1kv6n	107	35	(	(	-LRB-
cord-022290-p0l1kv6n	107	36	Krtiusslich	Krtiusslich	NNP
cord-022290-p0l1kv6n	107	37	and	and	CC
cord-022290-p0l1kv6n	107	38	Wimmer	Wimmer	NNP
cord-022290-p0l1kv6n	107	39	,	,	,
cord-022290-p0l1kv6n	107	40	1988	1988	CD
cord-022290-p0l1kv6n	107	41	;	;	:
cord-022290-p0l1kv6n	107	42	Harmon	Harmon	NNP
cord-022290-p0l1kv6n	107	43	et	et	NNP
cord-022290-p0l1kv6n	107	44	al	al	NNP
cord-022290-p0l1kv6n	107	45	.	.	NNP
cord-022290-p0l1kv6n	107	46	,	,	,
cord-022290-p0l1kv6n	107	47	1992	1992	CD
cord-022290-p0l1kv6n	107	48	)	)	-RRB-
cord-022290-p0l1kv6n	107	49	.	.	.
cord-022290-p0l1kv6n	108	1	Kinetic	kinetic	JJ
cord-022290-p0l1kv6n	108	2	evidence	evidence	NN
cord-022290-p0l1kv6n	108	3	obtained	obtain	VBN
cord-022290-p0l1kv6n	108	4	with	with	IN
cord-022290-p0l1kv6n	108	5	encephalomyocarditis	encephalomyocarditis	NNP
cord-022290-p0l1kv6n	108	6	virus	virus	NN
cord-022290-p0l1kv6n	108	7	(	(	-LRB-
cord-022290-p0l1kv6n	108	8	EMCV	EMCV	NNP
cord-022290-p0l1kv6n	108	9	)	)	-RRB-
cord-022290-p0l1kv6n	108	10	also	also	RB
cord-022290-p0l1kv6n	108	11	suggests	suggest	VBZ
cord-022290-p0l1kv6n	108	12	that	that	IN
cord-022290-p0l1kv6n	108	13	the	the	DT
cord-022290-p0l1kv6n	108	14	cleavage	cleavage	NN
cord-022290-p0l1kv6n	108	15	in	in	IN
cord-022290-p0l1kv6n	108	16	cis	cis	NNP
cord-022290-p0l1kv6n	108	17	at	at	IN
cord-022290-p0l1kv6n	108	18	both	both	CC
cord-022290-p0l1kv6n	108	19	the	the	DT
cord-022290-p0l1kv6n	108	20	amino	amino	NNS
cord-022290-p0l1kv6n	108	21	and	and	CC
cord-022290-p0l1kv6n	108	22	carboxy	carboxy	NN
cord-022290-p0l1kv6n	108	23	termini	terminus	NNS
cord-022290-p0l1kv6n	108	24	of	of	IN
cord-022290-p0l1kv6n	108	25	3C	3C	NNP
cord-022290-p0l1kv6n	108	26	is	be	VBZ
cord-022290-p0l1kv6n	108	27	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	108	28	(	(	-LRB-
cord-022290-p0l1kv6n	108	29	Palmenberg	Palmenberg	NNP
cord-022290-p0l1kv6n	108	30	and	and	CC
cord-022290-p0l1kv6n	108	31	Rueckert	Rueckert	NNP
cord-022290-p0l1kv6n	108	32	,	,	,
cord-022290-p0l1kv6n	108	33	1982	1982	CD
cord-022290-p0l1kv6n	108	34	)	)	-RRB-
cord-022290-p0l1kv6n	108	35	.	.	.
cord-022290-p0l1kv6n	109	1	Another	another	DT
cord-022290-p0l1kv6n	109	2	possible	possible	JJ
cord-022290-p0l1kv6n	109	3	interpretation	interpretation	NN
cord-022290-p0l1kv6n	109	4	of	of	IN
cord-022290-p0l1kv6n	109	5	these	these	DT
cord-022290-p0l1kv6n	109	6	data	datum	NNS
cord-022290-p0l1kv6n	109	7	is	be	VBZ
cord-022290-p0l1kv6n	109	8	that	that	IN
cord-022290-p0l1kv6n	109	9	the	the	DT
cord-022290-p0l1kv6n	109	10	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	109	11	are	be	VBP
cord-022290-p0l1kv6n	109	12	performed	perform	VBN
cord-022290-p0l1kv6n	109	13	by	by	IN
cord-022290-p0l1kv6n	109	14	another	another	DT
cord-022290-p0l1kv6n	109	15	3C	3c	NN
cord-022290-p0l1kv6n	109	16	proteinase	proteinase	NN
cord-022290-p0l1kv6n	109	17	within	within	IN
cord-022290-p0l1kv6n	109	18	a	a	DT
cord-022290-p0l1kv6n	109	19	tight	tight	JJ
cord-022290-p0l1kv6n	109	20	dimer	dimer	NN
cord-022290-p0l1kv6n	109	21	or	or	CC
cord-022290-p0l1kv6n	109	22	larger	large	JJR
cord-022290-p0l1kv6n	109	23	polymer	polymer	NN
cord-022290-p0l1kv6n	109	24	.	.	.
cord-022290-p0l1kv6n	110	1	Further	further	JJ
cord-022290-p0l1kv6n	110	2	evidence	evidence	NN
cord-022290-p0l1kv6n	110	3	for	for	IN
cord-022290-p0l1kv6n	110	4	an	an	DT
cord-022290-p0l1kv6n	110	5	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	110	6	,	,	,
cord-022290-p0l1kv6n	110	7	autocatalytic	autocatalytic	JJ
cord-022290-p0l1kv6n	110	8	cleavage	cleavage	NN
cord-022290-p0l1kv6n	110	9	of	of	IN
cord-022290-p0l1kv6n	110	10	the	the	DT
cord-022290-p0l1kv6n	110	11	3C	3C	NNP
cord-022290-p0l1kv6n	110	12	proteinase	proteinase	NN
cord-022290-p0l1kv6n	110	13	was	be	VBD
cord-022290-p0l1kv6n	110	14	provided	provide	VBN
cord-022290-p0l1kv6n	110	15	by	by	IN
cord-022290-p0l1kv6n	110	16	Hanecak	Hanecak	NNP
cord-022290-p0l1kv6n	110	17	et	et	NNP
cord-022290-p0l1kv6n	110	18	al	al	NNP
cord-022290-p0l1kv6n	110	19	.	.	.
cord-022290-p0l1kv6n	111	1	(	(	-LRB-
cord-022290-p0l1kv6n	111	2	1984	1984	CD
cord-022290-p0l1kv6n	111	3	)	)	-RRB-
cord-022290-p0l1kv6n	111	4	.	.	.
cord-022290-p0l1kv6n	112	1	The	the	DT
cord-022290-p0l1kv6n	112	2	crystal	crystal	NN
cord-022290-p0l1kv6n	112	3	structures	structure	NNS
cord-022290-p0l1kv6n	112	4	of	of	IN
cord-022290-p0l1kv6n	112	5	3C	3C	NNP
cord-022290-p0l1kv6n	112	6	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	112	7	have	have	VBP
cord-022290-p0l1kv6n	112	8	allowed	allow	VBN
cord-022290-p0l1kv6n	112	9	one	one	CD
cord-022290-p0l1kv6n	112	10	to	to	TO
cord-022290-p0l1kv6n	112	11	deduce	deduce	VB
cord-022290-p0l1kv6n	112	12	a	a	DT
cord-022290-p0l1kv6n	112	13	structural	structural	JJ
cord-022290-p0l1kv6n	112	14	model	model	NN
cord-022290-p0l1kv6n	112	15	for	for	IN
cord-022290-p0l1kv6n	112	16	an	an	DT
cord-022290-p0l1kv6n	112	17	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	112	18	cleavage	cleavage	NN
cord-022290-p0l1kv6n	112	19	of	of	IN
cord-022290-p0l1kv6n	112	20	3C	3C	NNP
cord-022290-p0l1kv6n	112	21	at	at	IN
cord-022290-p0l1kv6n	112	22	its	-PRON-	PRP$
cord-022290-p0l1kv6n	112	23	own	own	JJ
cord-022290-p0l1kv6n	112	24	amino	amino	NN
cord-022290-p0l1kv6n	112	25	-	-	HYPH
cord-022290-p0l1kv6n	112	26	terminus	terminus	NN
cord-022290-p0l1kv6n	112	27	(	(	-LRB-
cord-022290-p0l1kv6n	112	28	Matthews	Matthews	NNP
cord-022290-p0l1kv6n	112	29	et	et	NNP
cord-022290-p0l1kv6n	112	30	al	al	NNP
cord-022290-p0l1kv6n	112	31	.	.	NNP
cord-022290-p0l1kv6n	112	32	,	,	,
cord-022290-p0l1kv6n	112	33	1994	1994	CD
cord-022290-p0l1kv6n	112	34	;	;	:
cord-022290-p0l1kv6n	112	35	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	112	36	et	et	NNP
cord-022290-p0l1kv6n	112	37	al	al	NNP
cord-022290-p0l1kv6n	112	38	.	.	NNP
cord-022290-p0l1kv6n	112	39	,	,	,
cord-022290-p0l1kv6n	112	40	1997	1997	CD
cord-022290-p0l1kv6n	112	41	)	)	-RRB-
cord-022290-p0l1kv6n	112	42	.	.	.
cord-022290-p0l1kv6n	113	1	This	this	DT
cord-022290-p0l1kv6n	113	2	model	model	NN
cord-022290-p0l1kv6n	113	3	proposes	propose	VBZ
cord-022290-p0l1kv6n	113	4	that	that	IN
cord-022290-p0l1kv6n	113	5	the	the	DT
cord-022290-p0l1kv6n	113	6	amino	amino	NN
cord-022290-p0l1kv6n	113	7	-	-	HYPH
cord-022290-p0l1kv6n	113	8	terminal	terminal	NN
cord-022290-p0l1kv6n	113	9	helix	helix	NN
cord-022290-p0l1kv6n	113	10	,	,	,
cord-022290-p0l1kv6n	113	11	which	which	WDT
cord-022290-p0l1kv6n	113	12	is	be	VBZ
cord-022290-p0l1kv6n	113	13	a	a	DT
cord-022290-p0l1kv6n	113	14	unique	unique	JJ
cord-022290-p0l1kv6n	113	15	feature	feature	NN
cord-022290-p0l1kv6n	113	16	of	of	IN
cord-022290-p0l1kv6n	113	17	the	the	DT
cord-022290-p0l1kv6n	113	18	3C	3c	NN
cord-022290-p0l1kv6n	113	19	proteinase	proteinase	NN
cord-022290-p0l1kv6n	113	20	,	,	,
cord-022290-p0l1kv6n	113	21	folds	fold	VBZ
cord-022290-p0l1kv6n	113	22	out	out	IN
cord-022290-p0l1kv6n	113	23	of	of	IN
cord-022290-p0l1kv6n	113	24	the	the	DT
cord-022290-p0l1kv6n	113	25	active	active	JJ
cord-022290-p0l1kv6n	113	26	site	site	NN
cord-022290-p0l1kv6n	113	27	of	of	IN
cord-022290-p0l1kv6n	113	28	3C	3C	NNP
cord-022290-p0l1kv6n	113	29	after	after	IN
cord-022290-p0l1kv6n	113	30	3C	3C	NNP
cord-022290-p0l1kv6n	113	31	has	have	VBZ
cord-022290-p0l1kv6n	113	32	cleaved	cleave	VBN
cord-022290-p0l1kv6n	113	33	its	-PRON-	PRP$
cord-022290-p0l1kv6n	113	34	own	own	JJ
cord-022290-p0l1kv6n	113	35	amino	amino	NN
cord-022290-p0l1kv6n	113	36	-	-	HYPH
cord-022290-p0l1kv6n	113	37	terminus	terminus	NN
cord-022290-p0l1kv6n	113	38	.	.	.
cord-022290-p0l1kv6n	114	1	How	how	WRB
cord-022290-p0l1kv6n	114	2	and	and	CC
cord-022290-p0l1kv6n	114	3	if	if	IN
cord-022290-p0l1kv6n	114	4	the	the	DT
cord-022290-p0l1kv6n	114	5	3C	3c	NN
cord-022290-p0l1kv6n	114	6	proteinase	proteinase	NN
cord-022290-p0l1kv6n	114	7	could	could	MD
cord-022290-p0l1kv6n	114	8	cleave	cleave	VB
cord-022290-p0l1kv6n	114	9	its	-PRON-	PRP$
cord-022290-p0l1kv6n	114	10	own	own	JJ
cord-022290-p0l1kv6n	114	11	carboxy	carboxy	JJ
cord-022290-p0l1kv6n	114	12	-	-	HYPH
cord-022290-p0l1kv6n	114	13	terminus	terminus	NN
cord-022290-p0l1kv6n	114	14	in	in	IN
cord-022290-p0l1kv6n	114	15	an	an	DT
cord-022290-p0l1kv6n	114	16	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	114	17	reaction	reaction	NN
cord-022290-p0l1kv6n	114	18	is	be	VBZ
cord-022290-p0l1kv6n	114	19	much	much	RB
cord-022290-p0l1kv6n	114	20	less	less	RBR
cord-022290-p0l1kv6n	114	21	obvious	obvious	JJ
cord-022290-p0l1kv6n	114	22	.	.	.
cord-022290-p0l1kv6n	115	1	An	an	DT
cord-022290-p0l1kv6n	115	2	additional	additional	JJ
cord-022290-p0l1kv6n	115	3	function	function	NN
cord-022290-p0l1kv6n	115	4	of	of	IN
cord-022290-p0l1kv6n	115	5	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	115	6	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	115	7	is	be	VBZ
cord-022290-p0l1kv6n	115	8	the	the	DT
cord-022290-p0l1kv6n	115	9	inhibition	inhibition	NN
cord-022290-p0l1kv6n	115	10	or	or	CC
cord-022290-p0l1kv6n	115	11	at	at	IN
cord-022290-p0l1kv6n	115	12	least	least	JJS
cord-022290-p0l1kv6n	115	13	down	down	IN
cord-022290-p0l1kv6n	115	14	-	-	HYPH
cord-022290-p0l1kv6n	115	15	regulation	regulation	NN
cord-022290-p0l1kv6n	115	16	of	of	IN
cord-022290-p0l1kv6n	115	17	specific	specific	JJ
cord-022290-p0l1kv6n	115	18	host	host	NN
cord-022290-p0l1kv6n	115	19	cell	cell	NN
cord-022290-p0l1kv6n	115	20	functions	function	NNS
cord-022290-p0l1kv6n	115	21	which	which	WDT
cord-022290-p0l1kv6n	115	22	compete	compete	VBP
cord-022290-p0l1kv6n	115	23	with	with	IN
cord-022290-p0l1kv6n	115	24	the	the	DT
cord-022290-p0l1kv6n	115	25	viral	viral	JJ
cord-022290-p0l1kv6n	115	26	replication	replication	NN
cord-022290-p0l1kv6n	115	27	cycle	cycle	NN
cord-022290-p0l1kv6n	115	28	.	.	.
cord-022290-p0l1kv6n	116	1	The	the	DT
cord-022290-p0l1kv6n	116	2	entero	entero	NNP
cord-022290-p0l1kv6n	116	3	-	-	HYPH
cord-022290-p0l1kv6n	116	4	and	and	CC
cord-022290-p0l1kv6n	116	5	rhinoviral	rhinoviral	NNP
cord-022290-p0l1kv6n	116	6	2A	2A	NNP
cord-022290-p0l1kv6n	116	7	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	116	8	cleave	cleave	VBP
cord-022290-p0l1kv6n	116	9	specifically	specifically	RB
cord-022290-p0l1kv6n	116	10	one	one	CD
cord-022290-p0l1kv6n	116	11	of	of	IN
cord-022290-p0l1kv6n	116	12	the	the	DT
cord-022290-p0l1kv6n	116	13	cellular	cellular	JJ
cord-022290-p0l1kv6n	116	14	proteins	protein	NNS
cord-022290-p0l1kv6n	116	15	that	that	WDT
cord-022290-p0l1kv6n	116	16	forms	form	VBZ
cord-022290-p0l1kv6n	116	17	part	part	NN
cord-022290-p0l1kv6n	116	18	of	of	IN
cord-022290-p0l1kv6n	116	19	the	the	DT
cord-022290-p0l1kv6n	116	20	caprecognition	caprecognition	NN
cord-022290-p0l1kv6n	116	21	complex	complex	NN
cord-022290-p0l1kv6n	116	22	(	(	-LRB-
cord-022290-p0l1kv6n	116	23	eIF4	eif4	IN
cord-022290-p0l1kv6n	116	24	G	G	NNP
cord-022290-p0l1kv6n	116	25	)	)	-RRB-
cord-022290-p0l1kv6n	117	1	(	(	-LRB-
cord-022290-p0l1kv6n	117	2	Lamphear	Lamphear	NNP
cord-022290-p0l1kv6n	117	3	et	et	NNP
cord-022290-p0l1kv6n	117	4	al	al	NNP
cord-022290-p0l1kv6n	117	5	.	.	.
cord-022290-p0l1kv6n	118	1	,	,	,
cord-022290-p0l1kv6n	118	2	1993	1993	CD
cord-022290-p0l1kv6n	118	3	;	;	:
cord-022290-p0l1kv6n	118	4	Sommergruber	Sommergruber	NNP
cord-022290-p0l1kv6n	118	5	et	et	NNP
cord-022290-p0l1kv6n	118	6	al	al	NNP
cord-022290-p0l1kv6n	118	7	.	.	NNP
cord-022290-p0l1kv6n	118	8	,	,	,
cord-022290-p0l1kv6n	118	9	1994a	1994a	CD
cord-022290-p0l1kv6n	118	10	;	;	.
cord-022290-p0l1kv6n	119	1	Haghighat	Haghighat	NNP
cord-022290-p0l1kv6n	119	2	et	et	NNP
cord-022290-p0l1kv6n	119	3	al	al	NNP
cord-022290-p0l1kv6n	119	4	.	.	NNP
cord-022290-p0l1kv6n	119	5	,	,	,
cord-022290-p0l1kv6n	119	6	1996	1996	CD
cord-022290-p0l1kv6n	119	7	)	)	-RRB-
cord-022290-p0l1kv6n	119	8	.	.	.
cord-022290-p0l1kv6n	120	1	This	this	DT
cord-022290-p0l1kv6n	120	2	serves	serve	VBZ
cord-022290-p0l1kv6n	120	3	to	to	IN
cord-022290-p0l1kv6n	120	4	down	down	RB
cord-022290-p0l1kv6n	120	5	-	-	HYPH
cord-022290-p0l1kv6n	120	6	regulate	regulate	VB
cord-022290-p0l1kv6n	120	7	the	the	DT
cord-022290-p0l1kv6n	120	8	translation	translation	NN
cord-022290-p0l1kv6n	120	9	of	of	IN
cord-022290-p0l1kv6n	120	10	capped	cap	VBN
cord-022290-p0l1kv6n	120	11	host	host	NN
cord-022290-p0l1kv6n	120	12	cell	cell	NN
cord-022290-p0l1kv6n	120	13	mRNAs	mrnas	CD
cord-022290-p0l1kv6n	120	14	which	which	WDT
cord-022290-p0l1kv6n	120	15	competes	compete	VBZ
cord-022290-p0l1kv6n	120	16	with	with	IN
cord-022290-p0l1kv6n	120	17	the	the	DT
cord-022290-p0l1kv6n	120	18	translation	translation	NN
cord-022290-p0l1kv6n	120	19	of	of	IN
cord-022290-p0l1kv6n	120	20	the	the	DT
cord-022290-p0l1kv6n	120	21	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	120	22	RNA	RNA	NNP
cord-022290-p0l1kv6n	120	23	genome	genome	NN
cord-022290-p0l1kv6n	120	24	.	.	.
cord-022290-p0l1kv6n	121	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	121	2	is	be	VBZ
cord-022290-p0l1kv6n	121	3	remarkable	remarkable	JJ
cord-022290-p0l1kv6n	121	4	that	that	IN
cord-022290-p0l1kv6n	121	5	the	the	DT
cord-022290-p0l1kv6n	121	6	L	L	NNP
cord-022290-p0l1kv6n	121	7	proteinase	proteinase	NN
cord-022290-p0l1kv6n	121	8	of	of	IN
cord-022290-p0l1kv6n	121	9	aphthoviruses	aphthoviruse	NNS
cord-022290-p0l1kv6n	121	10	,	,	,
cord-022290-p0l1kv6n	121	11	in	in	IN
cord-022290-p0l1kv6n	121	12	spite	spite	NN
cord-022290-p0l1kv6n	121	13	of	of	IN
cord-022290-p0l1kv6n	121	14	being	be	VBG
cord-022290-p0l1kv6n	121	15	a	a	DT
cord-022290-p0l1kv6n	121	16	different	different	JJ
cord-022290-p0l1kv6n	121	17	proteinase	proteinase	NN
cord-022290-p0l1kv6n	121	18	,	,	,
cord-022290-p0l1kv6n	121	19	performs	perform	VBZ
cord-022290-p0l1kv6n	121	20	the	the	DT
cord-022290-p0l1kv6n	121	21	same	same	JJ
cord-022290-p0l1kv6n	121	22	function	function	NN
cord-022290-p0l1kv6n	121	23	.	.	.
cord-022290-p0l1kv6n	122	1	The	the	DT
cord-022290-p0l1kv6n	122	2	entero-/	entero-/	CD
cord-022290-p0l1kv6n	122	3	rhinoviral	rhinoviral	NNP
cord-022290-p0l1kv6n	122	4	2A	2A	NNP
cord-022290-p0l1kv6n	122	5	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	122	6	and	and	CC
cord-022290-p0l1kv6n	122	7	the	the	DT
cord-022290-p0l1kv6n	122	8	aphthoviral	aphthoviral	NNP
cord-022290-p0l1kv6n	122	9	L	L	NNP
cord-022290-p0l1kv6n	122	10	proteinase	proteinase	NN
cord-022290-p0l1kv6n	122	11	-	-	HYPH
cord-022290-p0l1kv6n	122	12	mediated	mediate	VBN
cord-022290-p0l1kv6n	122	13	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	122	14	of	of	IN
cord-022290-p0l1kv6n	122	15	eIF4	eif4	IN
cord-022290-p0l1kv6n	122	16	G	g	NN
cord-022290-p0l1kv6n	122	17	occur	occur	VBP
cord-022290-p0l1kv6n	122	18	in	in	IN
cord-022290-p0l1kv6n	122	19	different	different	JJ
cord-022290-p0l1kv6n	122	20	places	place	NNS
cord-022290-p0l1kv6n	122	21	on	on	IN
cord-022290-p0l1kv6n	122	22	the	the	DT
cord-022290-p0l1kv6n	122	23	molecule	molecule	NN
cord-022290-p0l1kv6n	123	1	(	(	-LRB-
cord-022290-p0l1kv6n	123	2	Kirchweger	Kirchweger	NNP
cord-022290-p0l1kv6n	123	3	et	et	NNP
cord-022290-p0l1kv6n	123	4	al	al	NNP
cord-022290-p0l1kv6n	123	5	.	.	NNP
cord-022290-p0l1kv6n	123	6	,	,	,
cord-022290-p0l1kv6n	123	7	1994	1994	CD
cord-022290-p0l1kv6n	123	8	)	)	-RRB-
cord-022290-p0l1kv6n	123	9	.	.	.
cord-022290-p0l1kv6n	124	1	The	the	DT
cord-022290-p0l1kv6n	124	2	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	124	3	which	which	WDT
cord-022290-p0l1kv6n	124	4	do	do	VBP
cord-022290-p0l1kv6n	124	5	not	not	RB
cord-022290-p0l1kv6n	124	6	have	have	VB
cord-022290-p0l1kv6n	124	7	a	a	DT
cord-022290-p0l1kv6n	124	8	second	second	JJ
cord-022290-p0l1kv6n	124	9	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	124	10	activity	activity	NN
cord-022290-p0l1kv6n	124	11	besides	besides	IN
cord-022290-p0l1kv6n	124	12	3C	3C	NNP
cord-022290-p0l1kv6n	124	13	do	do	VBP
cord-022290-p0l1kv6n	124	14	not	not	RB
cord-022290-p0l1kv6n	124	15	cleave	cleave	VB
cord-022290-p0l1kv6n	124	16	eIF4	eIF4	NNP
cord-022290-p0l1kv6n	124	17	G	g	NN
cord-022290-p0l1kv6n	124	18	or	or	CC
cord-022290-p0l1kv6n	124	19	inhibit	inhibit	VB
cord-022290-p0l1kv6n	124	20	host	host	NN
cord-022290-p0l1kv6n	124	21	cell	cell	NN
cord-022290-p0l1kv6n	124	22	translation	translation	NN
cord-022290-p0l1kv6n	124	23	by	by	IN
cord-022290-p0l1kv6n	124	24	this	this	DT
cord-022290-p0l1kv6n	124	25	mechanism	mechanism	NN
cord-022290-p0l1kv6n	124	26	.	.	.
cord-022290-p0l1kv6n	125	1	Hepatitis	Hepatitis	NNP
cord-022290-p0l1kv6n	125	2	A	a	DT
cord-022290-p0l1kv6n	125	3	virus	virus	NN
cord-022290-p0l1kv6n	125	4	even	even	RB
cord-022290-p0l1kv6n	125	5	requires	require	VBZ
cord-022290-p0l1kv6n	125	6	intact	intact	JJ
cord-022290-p0l1kv6n	125	7	eIF4	eif4	IN
cord-022290-p0l1kv6n	125	8	G	g	NN
cord-022290-p0l1kv6n	125	9	for	for	IN
cord-022290-p0l1kv6n	125	10	the	the	DT
cord-022290-p0l1kv6n	125	11	translation	translation	NN
cord-022290-p0l1kv6n	125	12	of	of	IN
cord-022290-p0l1kv6n	125	13	its	-PRON-	PRP$
cord-022290-p0l1kv6n	125	14	own	own	JJ
cord-022290-p0l1kv6n	125	15	genome	genome	NN
cord-022290-p0l1kv6n	125	16	(	(	-LRB-
cord-022290-p0l1kv6n	125	17	Borman	Borman	NNP
cord-022290-p0l1kv6n	125	18	and	and	CC
cord-022290-p0l1kv6n	125	19	Kean	Kean	NNP
cord-022290-p0l1kv6n	125	20	,	,	,
cord-022290-p0l1kv6n	125	21	1997	1997	CD
cord-022290-p0l1kv6n	125	22	)	)	-RRB-
cord-022290-p0l1kv6n	125	23	.	.	.
cord-022290-p0l1kv6n	126	1	There	there	EX
cord-022290-p0l1kv6n	126	2	are	be	VBP
cord-022290-p0l1kv6n	126	3	also	also	RB
cord-022290-p0l1kv6n	126	4	reports	report	NNS
cord-022290-p0l1kv6n	126	5	of	of	IN
cord-022290-p0l1kv6n	126	6	host	host	NN
cord-022290-p0l1kv6n	126	7	cell	cell	NN
cord-022290-p0l1kv6n	126	8	proteins	protein	NNS
cord-022290-p0l1kv6n	126	9	being	be	VBG
cord-022290-p0l1kv6n	126	10	substrates	substrate	NNS
cord-022290-p0l1kv6n	126	11	of	of	IN
cord-022290-p0l1kv6n	126	12	the	the	DT
cord-022290-p0l1kv6n	126	13	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	126	14	3C	3C	NNP
cord-022290-p0l1kv6n	126	15	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	126	16	.	.	.
cord-022290-p0l1kv6n	127	1	Most	Most	JJS
cord-022290-p0l1kv6n	127	2	of	of	IN
cord-022290-p0l1kv6n	127	3	these	these	DT
cord-022290-p0l1kv6n	127	4	cellular	cellular	JJ
cord-022290-p0l1kv6n	127	5	substrates	substrate	NNS
cord-022290-p0l1kv6n	127	6	of	of	IN
cord-022290-p0l1kv6n	127	7	the	the	DT
cord-022290-p0l1kv6n	127	8	3C	3C	NNP
cord-022290-p0l1kv6n	127	9	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	127	10	are	be	VBP
cord-022290-p0l1kv6n	127	11	involved	involve	VBN
cord-022290-p0l1kv6n	127	12	in	in	IN
cord-022290-p0l1kv6n	127	13	some	some	DT
cord-022290-p0l1kv6n	127	14	aspect	aspect	NN
cord-022290-p0l1kv6n	127	15	of	of	IN
cord-022290-p0l1kv6n	127	16	cellular	cellular	JJ
cord-022290-p0l1kv6n	127	17	translation	translation	NN
cord-022290-p0l1kv6n	127	18	or	or	CC
cord-022290-p0l1kv6n	127	19	replication	replication	NN
cord-022290-p0l1kv6n	127	20	Yalamanchili	Yalamanchili	NNP
cord-022290-p0l1kv6n	127	21	et	et	NNP
cord-022290-p0l1kv6n	127	22	al	al	NNP
cord-022290-p0l1kv6n	127	23	.	.	NNP
cord-022290-p0l1kv6n	127	24	,	,	,
cord-022290-p0l1kv6n	127	25	1997	1997	CD
cord-022290-p0l1kv6n	127	26	)	)	-RRB-
cord-022290-p0l1kv6n	127	27	.	.	.
cord-022290-p0l1kv6n	128	1	Thus	thus	RB
cord-022290-p0l1kv6n	128	2	,	,	,
cord-022290-p0l1kv6n	128	3	there	there	EX
cord-022290-p0l1kv6n	128	4	are	be	VBP
cord-022290-p0l1kv6n	128	5	three	three	CD
cord-022290-p0l1kv6n	128	6	main	main	JJ
cord-022290-p0l1kv6n	128	7	functions	function	NNS
cord-022290-p0l1kv6n	128	8	of	of	IN
cord-022290-p0l1kv6n	128	9	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	128	10	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	128	11	:	:	:
cord-022290-p0l1kv6n	128	12	the	the	DT
cord-022290-p0l1kv6n	128	13	specific	specific	JJ
cord-022290-p0l1kv6n	128	14	processing	processing	NN
cord-022290-p0l1kv6n	128	15	of	of	IN
cord-022290-p0l1kv6n	128	16	the	the	DT
cord-022290-p0l1kv6n	128	17	viral	viral	JJ
cord-022290-p0l1kv6n	128	18	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	128	19	,	,	,
cord-022290-p0l1kv6n	128	20	covalent	covalent	JJ
cord-022290-p0l1kv6n	128	21	modification	modification	NN
cord-022290-p0l1kv6n	128	22	of	of	IN
cord-022290-p0l1kv6n	128	23	the	the	DT
cord-022290-p0l1kv6n	128	24	precursors	precursor	NNS
cord-022290-p0l1kv6n	128	25	of	of	IN
cord-022290-p0l1kv6n	128	26	the	the	DT
cord-022290-p0l1kv6n	128	27	viral	viral	JJ
cord-022290-p0l1kv6n	128	28	capsid	capsid	NN
cord-022290-p0l1kv6n	128	29	and	and	CC
cord-022290-p0l1kv6n	128	30	down	down	IN
cord-022290-p0l1kv6n	128	31	regulation	regulation	NN
cord-022290-p0l1kv6n	128	32	of	of	IN
cord-022290-p0l1kv6n	128	33	host	host	NN
cord-022290-p0l1kv6n	128	34	cell	cell	NN
cord-022290-p0l1kv6n	128	35	processes	process	NNS
cord-022290-p0l1kv6n	128	36	by	by	IN
cord-022290-p0l1kv6n	128	37	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	128	38	cleavage	cleavage	NN
cord-022290-p0l1kv6n	128	39	of	of	IN
cord-022290-p0l1kv6n	128	40	host	host	NN
cord-022290-p0l1kv6n	128	41	cell	cell	NN
cord-022290-p0l1kv6n	128	42	proteins	protein	NNS
cord-022290-p0l1kv6n	128	43	(	(	-LRB-
cord-022290-p0l1kv6n	128	44	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	128	45	and	and	CC
cord-022290-p0l1kv6n	128	46	Snijder	Snijder	NNP
cord-022290-p0l1kv6n	128	47	,	,	,
cord-022290-p0l1kv6n	128	48	1996	1996	CD
cord-022290-p0l1kv6n	128	49	;	;	:
cord-022290-p0l1kv6n	128	50	Kay	Kay	NNP
cord-022290-p0l1kv6n	128	51	and	and	CC
cord-022290-p0l1kv6n	128	52	Dunn	Dunn	NNP
cord-022290-p0l1kv6n	128	53	,	,	,
cord-022290-p0l1kv6n	128	54	1990	1990	CD
cord-022290-p0l1kv6n	128	55	;	;	:
cord-022290-p0l1kv6n	128	56	Kr	Kr	NNP
cord-022290-p0l1kv6n	128	57	~	~	NNP
cord-022290-p0l1kv6n	128	58	usslich	usslich	NNP
cord-022290-p0l1kv6n	128	59	and	and	CC
cord-022290-p0l1kv6n	128	60	Wimmer	Wimmer	NNP
cord-022290-p0l1kv6n	128	61	,	,	,
cord-022290-p0l1kv6n	128	62	1988	1988	CD
cord-022290-p0l1kv6n	128	63	;	;	:
cord-022290-p0l1kv6n	128	64	Ryan	Ryan	NNP
cord-022290-p0l1kv6n	128	65	and	and	CC
cord-022290-p0l1kv6n	128	66	Flint	Flint	NNP
cord-022290-p0l1kv6n	128	67	,	,	,
cord-022290-p0l1kv6n	128	68	1997	1997	CD
cord-022290-p0l1kv6n	128	69	)	)	-RRB-
cord-022290-p0l1kv6n	128	70	.	.	.
cord-022290-p0l1kv6n	129	1	Cotranslational	Cotranslational	NNP
cord-022290-p0l1kv6n	129	2	,	,	,
cord-022290-p0l1kv6n	129	3	specific	specific	JJ
cord-022290-p0l1kv6n	129	4	processing	processing	NN
cord-022290-p0l1kv6n	129	5	of	of	IN
cord-022290-p0l1kv6n	129	6	a	a	DT
cord-022290-p0l1kv6n	129	7	viral	viral	JJ
cord-022290-p0l1kv6n	129	8	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	129	9	by	by	IN
cord-022290-p0l1kv6n	129	10	a	a	DT
cord-022290-p0l1kv6n	129	11	specific	specific	JJ
cord-022290-p0l1kv6n	129	12	viral	viral	JJ
cord-022290-p0l1kv6n	129	13	proteinase	proteinase	NN
cord-022290-p0l1kv6n	129	14	is	be	VBZ
cord-022290-p0l1kv6n	129	15	an	an	DT
cord-022290-p0l1kv6n	129	16	essential	essential	JJ
cord-022290-p0l1kv6n	129	17	part	part	NN
cord-022290-p0l1kv6n	129	18	of	of	IN
cord-022290-p0l1kv6n	129	19	viral	viral	JJ
cord-022290-p0l1kv6n	129	20	replication	replication	NN
cord-022290-p0l1kv6n	129	21	in	in	IN
cord-022290-p0l1kv6n	129	22	+	+	CC
cord-022290-p0l1kv6n	129	23	RNA	RNA	NNP
cord-022290-p0l1kv6n	129	24	viruses	virus	NNS
cord-022290-p0l1kv6n	129	25	.	.	.
cord-022290-p0l1kv6n	130	1	This	this	DT
cord-022290-p0l1kv6n	130	2	is	be	VBZ
cord-022290-p0l1kv6n	130	3	true	true	JJ
cord-022290-p0l1kv6n	130	4	even	even	RB
cord-022290-p0l1kv6n	130	5	for	for	IN
cord-022290-p0l1kv6n	130	6	some	some	DT
cord-022290-p0l1kv6n	130	7	families	family	NNS
cord-022290-p0l1kv6n	130	8	of	of	IN
cord-022290-p0l1kv6n	130	9	+	+	SYM
cord-022290-p0l1kv6n	130	10	RNA	RNA	NNP
cord-022290-p0l1kv6n	130	11	viruses	virus	NNS
cord-022290-p0l1kv6n	130	12	which	which	WDT
cord-022290-p0l1kv6n	130	13	have	have	VBP
cord-022290-p0l1kv6n	130	14	developed	develop	VBN
cord-022290-p0l1kv6n	130	15	additional	additional	JJ
cord-022290-p0l1kv6n	130	16	strategies	strategy	NNS
cord-022290-p0l1kv6n	130	17	to	to	TO
cord-022290-p0l1kv6n	130	18	generate	generate	VB
cord-022290-p0l1kv6n	130	19	individual	individual	JJ
cord-022290-p0l1kv6n	130	20	gene	gene	NN
cord-022290-p0l1kv6n	130	21	products	product	NNS
cord-022290-p0l1kv6n	130	22	from	from	IN
cord-022290-p0l1kv6n	130	23	a	a	DT
cord-022290-p0l1kv6n	130	24	single	single	JJ
cord-022290-p0l1kv6n	130	25	RNA	RNA	NNP
cord-022290-p0l1kv6n	130	26	genome	genome	NN
cord-022290-p0l1kv6n	130	27	,	,	,
cord-022290-p0l1kv6n	130	28	e.g.	e.g.	RB
cord-022290-p0l1kv6n	130	29	,	,	,
cord-022290-p0l1kv6n	130	30	subgenomic	subgenomic	NNP
cord-022290-p0l1kv6n	130	31	RNAs	RNAs	NNPS
cord-022290-p0l1kv6n	130	32	or	or	CC
cord-022290-p0l1kv6n	130	33	multiple	multiple	JJ
cord-022290-p0l1kv6n	130	34	ORFs	orf	NNS
cord-022290-p0l1kv6n	130	35	.	.	.
cord-022290-p0l1kv6n	131	1	Proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	131	2	cleavage	cleavage	NN
cord-022290-p0l1kv6n	131	3	as	as	IN
cord-022290-p0l1kv6n	131	4	a	a	DT
cord-022290-p0l1kv6n	131	5	covalent	covalent	JJ
cord-022290-p0l1kv6n	131	6	modification	modification	NN
cord-022290-p0l1kv6n	131	7	of	of	IN
cord-022290-p0l1kv6n	131	8	the	the	DT
cord-022290-p0l1kv6n	131	9	precursors	precursor	NNS
cord-022290-p0l1kv6n	131	10	of	of	IN
cord-022290-p0l1kv6n	131	11	viral	viral	JJ
cord-022290-p0l1kv6n	131	12	structural	structural	JJ
cord-022290-p0l1kv6n	131	13	proteins	protein	NNS
cord-022290-p0l1kv6n	131	14	is	be	VBZ
cord-022290-p0l1kv6n	131	15	even	even	RB
cord-022290-p0l1kv6n	131	16	more	more	RBR
cord-022290-p0l1kv6n	131	17	common	common	JJ
cord-022290-p0l1kv6n	131	18	and	and	CC
cord-022290-p0l1kv6n	131	19	occurs	occur	VBZ
cord-022290-p0l1kv6n	131	20	even	even	RB
cord-022290-p0l1kv6n	131	21	in	in	IN
cord-022290-p0l1kv6n	131	22	DNA	dna	NN
cord-022290-p0l1kv6n	131	23	viruses	virus	NNS
cord-022290-p0l1kv6n	131	24	.	.	.
cord-022290-p0l1kv6n	132	1	Down	down	IN
cord-022290-p0l1kv6n	132	2	-	-	HYPH
cord-022290-p0l1kv6n	132	3	regulation	regulation	NN
cord-022290-p0l1kv6n	132	4	of	of	IN
cord-022290-p0l1kv6n	132	5	the	the	DT
cord-022290-p0l1kv6n	132	6	host	host	NN
cord-022290-p0l1kv6n	132	7	cell	cell	NN
cord-022290-p0l1kv6n	132	8	metabolism	metabolism	NN
cord-022290-p0l1kv6n	132	9	by	by	IN
cord-022290-p0l1kv6n	132	10	specific	specific	JJ
cord-022290-p0l1kv6n	132	11	cleavage	cleavage	NN
cord-022290-p0l1kv6n	132	12	of	of	IN
cord-022290-p0l1kv6n	132	13	cellular	cellular	JJ
cord-022290-p0l1kv6n	132	14	proteins	protein	NNS
cord-022290-p0l1kv6n	132	15	is	be	VBZ
cord-022290-p0l1kv6n	132	16	a	a	DT
cord-022290-p0l1kv6n	132	17	mechanism	mechanism	NN
cord-022290-p0l1kv6n	132	18	which	which	WDT
cord-022290-p0l1kv6n	132	19	is	be	VBZ
cord-022290-p0l1kv6n	132	20	not	not	RB
cord-022290-p0l1kv6n	132	21	found	find	VBN
cord-022290-p0l1kv6n	132	22	in	in	IN
cord-022290-p0l1kv6n	132	23	all	all	DT
cord-022290-p0l1kv6n	132	24	viruses	virus	NNS
cord-022290-p0l1kv6n	132	25	.	.	.
cord-022290-p0l1kv6n	133	1	Given	give	VBN
cord-022290-p0l1kv6n	133	2	these	these	DT
cord-022290-p0l1kv6n	133	3	important	important	JJ
cord-022290-p0l1kv6n	133	4	functions	function	NNS
cord-022290-p0l1kv6n	133	5	,	,	,
cord-022290-p0l1kv6n	133	6	it	-PRON-	PRP
cord-022290-p0l1kv6n	133	7	is	be	VBZ
cord-022290-p0l1kv6n	133	8	not	not	RB
cord-022290-p0l1kv6n	133	9	surprising	surprising	JJ
cord-022290-p0l1kv6n	133	10	that	that	IN
cord-022290-p0l1kv6n	133	11	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	133	12	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	133	13	are	be	VBP
cord-022290-p0l1kv6n	133	14	ubiquitous	ubiquitous	JJ
cord-022290-p0l1kv6n	133	15	gene	gene	NN
cord-022290-p0l1kv6n	133	16	products	product	NNS
cord-022290-p0l1kv6n	133	17	in	in	IN
cord-022290-p0l1kv6n	133	18	all	all	DT
cord-022290-p0l1kv6n	134	1	+	+	CC
cord-022290-p0l1kv6n	134	2	RNA	RNA	NNP
cord-022290-p0l1kv6n	134	3	and	and	CC
cord-022290-p0l1kv6n	134	4	many	many	JJ
cord-022290-p0l1kv6n	134	5	other	other	JJ
cord-022290-p0l1kv6n	134	6	viruses	virus	NNS
cord-022290-p0l1kv6n	134	7	.	.	.
cord-022290-p0l1kv6n	135	1	The	the	DT
cord-022290-p0l1kv6n	135	2	major	major	JJ
cord-022290-p0l1kv6n	135	3	processing	processing	NN
cord-022290-p0l1kv6n	135	4	proteinase	proteinase	NN
cord-022290-p0l1kv6n	135	5	of	of	IN
cord-022290-p0l1kv6n	135	6	the	the	DT
cord-022290-p0l1kv6n	135	7	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	135	8	,	,	,
cord-022290-p0l1kv6n	135	9	the	the	DT
cord-022290-p0l1kv6n	135	10	3C	3C	NNP
cord-022290-p0l1kv6n	135	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	135	12	,	,	,
cord-022290-p0l1kv6n	135	13	belongs	belong	VBZ
cord-022290-p0l1kv6n	135	14	to	to	IN
cord-022290-p0l1kv6n	135	15	a	a	DT
cord-022290-p0l1kv6n	135	16	new	new	JJ
cord-022290-p0l1kv6n	135	17	family	family	NN
cord-022290-p0l1kv6n	135	18	of	of	IN
cord-022290-p0l1kv6n	135	19	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	135	20	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	135	21	:	:	:
cord-022290-p0l1kv6n	135	22	the	the	DT
cord-022290-p0l1kv6n	135	23	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	135	24	-	-	HYPH
cord-022290-p0l1kv6n	135	25	like	like	JJ
cord-022290-p0l1kv6n	135	26	cysteine	cysteine	NN
cord-022290-p0l1kv6n	135	27	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	135	28	(	(	-LRB-
cord-022290-p0l1kv6n	135	29	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	135	30	and	and	CC
cord-022290-p0l1kv6n	135	31	Snijder	Snijder	NNP
cord-022290-p0l1kv6n	135	32	,	,	,
cord-022290-p0l1kv6n	135	33	1996	1996	CD
cord-022290-p0l1kv6n	135	34	)	)	-RRB-
cord-022290-p0l1kv6n	135	35	.	.	.
cord-022290-p0l1kv6n	136	1	This	this	DT
cord-022290-p0l1kv6n	136	2	had	have	VBD
cord-022290-p0l1kv6n	136	3	initially	initially	RB
cord-022290-p0l1kv6n	136	4	been	be	VBN
cord-022290-p0l1kv6n	136	5	predicted	predict	VBN
cord-022290-p0l1kv6n	136	6	based	base	VBN
cord-022290-p0l1kv6n	136	7	on	on	IN
cord-022290-p0l1kv6n	136	8	analysis	analysis	NN
cord-022290-p0l1kv6n	136	9	of	of	IN
cord-022290-p0l1kv6n	136	10	the	the	DT
cord-022290-p0l1kv6n	136	11	sequence	sequence	NN
cord-022290-p0l1kv6n	136	12	of	of	IN
cord-022290-p0l1kv6n	136	13	the	the	DT
cord-022290-p0l1kv6n	136	14	3C	3C	NNP
cord-022290-p0l1kv6n	136	15	gene	gene	NN
cord-022290-p0l1kv6n	136	16	product	product	NN
cord-022290-p0l1kv6n	136	17	(	(	-LRB-
cord-022290-p0l1kv6n	136	18	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	136	19	et	et	NNP
cord-022290-p0l1kv6n	136	20	al	al	NNP
cord-022290-p0l1kv6n	136	21	.	.	.
cord-022290-p0l1kv6n	137	1	,	,	,
cord-022290-p0l1kv6n	137	2	1986	1986	CD
cord-022290-p0l1kv6n	138	1	(	(	-LRB-
cord-022290-p0l1kv6n	138	2	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	138	3	et	et	NNP
cord-022290-p0l1kv6n	138	4	al	al	NNP
cord-022290-p0l1kv6n	138	5	.	.	NNP
cord-022290-p0l1kv6n	138	6	,	,	,
cord-022290-p0l1kv6n	138	7	,	,	,
cord-022290-p0l1kv6n	138	8	1989	1989	CD
cord-022290-p0l1kv6n	138	9	Bazan	Bazan	NNP
cord-022290-p0l1kv6n	138	10	and	and	CC
cord-022290-p0l1kv6n	138	11	Fletterick	Fletterick	NNP
cord-022290-p0l1kv6n	138	12	,	,	,
cord-022290-p0l1kv6n	138	13	1988	1988	CD
cord-022290-p0l1kv6n	138	14	)	)	-RRB-
cord-022290-p0l1kv6n	138	15	.	.	.
cord-022290-p0l1kv6n	139	1	This	this	DT
cord-022290-p0l1kv6n	139	2	prediction	prediction	NN
cord-022290-p0l1kv6n	139	3	was	be	VBD
cord-022290-p0l1kv6n	139	4	shown	show	VBN
cord-022290-p0l1kv6n	139	5	to	to	TO
cord-022290-p0l1kv6n	139	6	be	be	VB
cord-022290-p0l1kv6n	139	7	correct	correct	JJ
cord-022290-p0l1kv6n	139	8	by	by	IN
cord-022290-p0l1kv6n	139	9	the	the	DT
cord-022290-p0l1kv6n	139	10	first	first	JJ
cord-022290-p0l1kv6n	139	11	crystal	crystal	NN
cord-022290-p0l1kv6n	139	12	structure	structure	NN
cord-022290-p0l1kv6n	139	13	of	of	IN
cord-022290-p0l1kv6n	139	14	a	a	DT
cord-022290-p0l1kv6n	139	15	3C	3c	NN
cord-022290-p0l1kv6n	139	16	proteinase	proteinase	NN
cord-022290-p0l1kv6n	139	17	(	(	-LRB-
cord-022290-p0l1kv6n	139	18	Allaire	Allaire	NNP
cord-022290-p0l1kv6n	139	19	et	et	NNP
cord-022290-p0l1kv6n	139	20	al	al	NNP
cord-022290-p0l1kv6n	139	21	.	.	NNP
cord-022290-p0l1kv6n	139	22	,	,	,
cord-022290-p0l1kv6n	139	23	1994	1994	CD
cord-022290-p0l1kv6n	139	24	)	)	-RRB-
cord-022290-p0l1kv6n	139	25	.	.	.
cord-022290-p0l1kv6n	140	1	Refined	refined	JJ
cord-022290-p0l1kv6n	140	2	crystal	crystal	NN
cord-022290-p0l1kv6n	140	3	structures	structure	NNS
cord-022290-p0l1kv6n	140	4	of	of	IN
cord-022290-p0l1kv6n	140	5	3C	3C	NNP
cord-022290-p0l1kv6n	140	6	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	140	7	have	have	VBP
cord-022290-p0l1kv6n	140	8	now	now	RB
cord-022290-p0l1kv6n	140	9	been	be	VBN
cord-022290-p0l1kv6n	140	10	published	publish	VBN
cord-022290-p0l1kv6n	140	11	for	for	IN
cord-022290-p0l1kv6n	140	12	the	the	DT
cord-022290-p0l1kv6n	140	13	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	140	14	from	from	IN
cord-022290-p0l1kv6n	140	15	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	140	16	A	a	DT
cord-022290-p0l1kv6n	140	17	virus	virus	NN
cord-022290-p0l1kv6n	140	18	(	(	-LRB-
cord-022290-p0l1kv6n	140	19	HAV	HAV	NNP
cord-022290-p0l1kv6n	140	20	)	)	-RRB-
cord-022290-p0l1kv6n	140	21	,	,	,
cord-022290-p0l1kv6n	140	22	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	140	23	(	(	-LRB-
cord-022290-p0l1kv6n	140	24	PV	PV	NNP
cord-022290-p0l1kv6n	140	25	)	)	-RRB-
cord-022290-p0l1kv6n	140	26	,	,	,
cord-022290-p0l1kv6n	140	27	and	and	CC
cord-022290-p0l1kv6n	140	28	human	human	JJ
cord-022290-p0l1kv6n	140	29	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	140	30	(	(	-LRB-
cord-022290-p0l1kv6n	140	31	HRV	HRV	NNP
cord-022290-p0l1kv6n	140	32	)	)	-RRB-
cord-022290-p0l1kv6n	140	33	(	(	-LRB-
cord-022290-p0l1kv6n	140	34	Matthews	Matthews	NNP
cord-022290-p0l1kv6n	140	35	et	et	NNP
cord-022290-p0l1kv6n	140	36	al	al	NNP
cord-022290-p0l1kv6n	140	37	.	.	.
cord-022290-p0l1kv6n	141	1	,	,	,
cord-022290-p0l1kv6n	141	2	1994	1994	CD
cord-022290-p0l1kv6n	141	3	;	;	:
cord-022290-p0l1kv6n	141	4	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	141	5	et	et	NNP
cord-022290-p0l1kv6n	141	6	al	al	NNP
cord-022290-p0l1kv6n	141	7	.	.	NNP
cord-022290-p0l1kv6n	141	8	,	,	,
cord-022290-p0l1kv6n	141	9	1997	1997	CD
cord-022290-p0l1kv6n	141	10	;	;	:
cord-022290-p0l1kv6n	141	11	Mosimann	Mosimann	NNP
cord-022290-p0l1kv6n	141	12	et	et	NNP
cord-022290-p0l1kv6n	141	13	al	al	NNP
cord-022290-p0l1kv6n	141	14	.	.	NNP
cord-022290-p0l1kv6n	141	15	,	,	,
cord-022290-p0l1kv6n	141	16	1997	1997	CD
cord-022290-p0l1kv6n	141	17	)	)	-RRB-
cord-022290-p0l1kv6n	141	18	.	.	.
cord-022290-p0l1kv6n	142	1	The	the	DT
cord-022290-p0l1kv6n	142	2	three	three	CD
cord-022290-p0l1kv6n	142	3	-	-	HYPH
cord-022290-p0l1kv6n	142	4	dimensional	dimensional	JJ
cord-022290-p0l1kv6n	142	5	structure	structure	NN
cord-022290-p0l1kv6n	142	6	of	of	IN
cord-022290-p0l1kv6n	142	7	the	the	DT
cord-022290-p0l1kv6n	142	8	3C	3C	NNP
cord-022290-p0l1kv6n	142	9	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	142	10	from	from	IN
cord-022290-p0l1kv6n	142	11	HAV	HAV	NNP
cord-022290-p0l1kv6n	142	12	and	and	CC
cord-022290-p0l1kv6n	142	13	PV	PV	NNP
cord-022290-p0l1kv6n	142	14	are	be	VBP
cord-022290-p0l1kv6n	142	15	shown	show	VBN
cord-022290-p0l1kv6n	142	16	in	in	IN
cord-022290-p0l1kv6n	142	17	Figs	Figs	NNPS
cord-022290-p0l1kv6n	142	18	.	.	.
cord-022290-p0l1kv6n	143	1	2	2	CD
cord-022290-p0l1kv6n	143	2	and	and	CC
cord-022290-p0l1kv6n	143	3	3	3	CD
cord-022290-p0l1kv6n	143	4	,	,	,
cord-022290-p0l1kv6n	143	5	respectively	respectively	RB
cord-022290-p0l1kv6n	143	6	.	.	.
cord-022290-p0l1kv6n	144	1	The	the	DT
cord-022290-p0l1kv6n	144	2	two	two	CD
cord-022290-p0l1kv6n	144	3	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	144	4	differ	differ	VBP
cord-022290-p0l1kv6n	144	5	in	in	IN
cord-022290-p0l1kv6n	144	6	size	size	NN
cord-022290-p0l1kv6n	144	7	and	and	CC
cord-022290-p0l1kv6n	144	8	belong	belong	VBP
cord-022290-p0l1kv6n	144	9	to	to	IN
cord-022290-p0l1kv6n	144	10	two	two	CD
cord-022290-p0l1kv6n	144	11	subclasses	subclass	NNS
cord-022290-p0l1kv6n	144	12	of	of	IN
cord-022290-p0l1kv6n	144	13	the	the	DT
cord-022290-p0l1kv6n	144	14	3C	3C	NNP
cord-022290-p0l1kv6n	144	15	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	144	16	.	.	.
cord-022290-p0l1kv6n	145	1	The	the	DT
cord-022290-p0l1kv6n	145	2	3C	3c	NN
cord-022290-p0l1kv6n	145	3	gene	gene	NN
cord-022290-p0l1kv6n	145	4	product	product	NN
cord-022290-p0l1kv6n	145	5	of	of	IN
cord-022290-p0l1kv6n	145	6	HAV	HAV	NNP
cord-022290-p0l1kv6n	145	7	consists	consist	VBZ
cord-022290-p0l1kv6n	145	8	of	of	IN
cord-022290-p0l1kv6n	145	9	219	219	CD
cord-022290-p0l1kv6n	145	10	residues	residue	NNS
cord-022290-p0l1kv6n	145	11	and	and	CC
cord-022290-p0l1kv6n	145	12	the	the	DT
cord-022290-p0l1kv6n	145	13	molecule	molecule	NN
cord-022290-p0l1kv6n	145	14	from	from	IN
cord-022290-p0l1kv6n	145	15	PV	PV	NNP
cord-022290-p0l1kv6n	145	16	consists	consist	VBZ
cord-022290-p0l1kv6n	145	17	of	of	IN
cord-022290-p0l1kv6n	145	18	183	183	CD
cord-022290-p0l1kv6n	145	19	residues	residue	NNS
cord-022290-p0l1kv6n	145	20	.	.	.
cord-022290-p0l1kv6n	146	1	In	in	IN
cord-022290-p0l1kv6n	146	2	spite	spite	NN
cord-022290-p0l1kv6n	146	3	of	of	IN
cord-022290-p0l1kv6n	146	4	the	the	DT
cord-022290-p0l1kv6n	146	5	size	size	NN
cord-022290-p0l1kv6n	146	6	difference	difference	NN
cord-022290-p0l1kv6n	146	7	,	,	,
cord-022290-p0l1kv6n	146	8	the	the	DT
cord-022290-p0l1kv6n	146	9	core	core	NN
cord-022290-p0l1kv6n	146	10	of	of	IN
cord-022290-p0l1kv6n	146	11	the	the	DT
cord-022290-p0l1kv6n	146	12	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	146	13	superimpose	superimpose	VBP
cord-022290-p0l1kv6n	146	14	surprisingly	surprisingly	RB
cord-022290-p0l1kv6n	146	15	well	well	RB
cord-022290-p0l1kv6n	146	16	.	.	.
cord-022290-p0l1kv6n	147	1	The	the	DT
cord-022290-p0l1kv6n	147	2	rms	rms	NN
cord-022290-p0l1kv6n	147	3	difference	difference	NN
cord-022290-p0l1kv6n	147	4	for	for	IN
cord-022290-p0l1kv6n	147	5	the	the	DT
cord-022290-p0l1kv6n	147	6	Ca	Ca	NNP
cord-022290-p0l1kv6n	147	7	-	-	HYPH
cord-022290-p0l1kv6n	147	8	atoms	atom	NNS
cord-022290-p0l1kv6n	147	9	of	of	IN
cord-022290-p0l1kv6n	147	10	154	154	CD
cord-022290-p0l1kv6n	147	11	residues	residue	NNS
cord-022290-p0l1kv6n	147	12	which	which	WDT
cord-022290-p0l1kv6n	147	13	superimpose	superimpose	VBP
cord-022290-p0l1kv6n	147	14	closely	closely	RB
cord-022290-p0l1kv6n	147	15	is	be	VBZ
cord-022290-p0l1kv6n	147	16	1.85A.	1.85a.	CD
cord-022290-p0l1kv6n	148	1	This	this	DT
cord-022290-p0l1kv6n	148	2	indicates	indicate	VBZ
cord-022290-p0l1kv6n	148	3	that	that	IN
cord-022290-p0l1kv6n	148	4	the	the	DT
cord-022290-p0l1kv6n	148	5	core	core	NN
cord-022290-p0l1kv6n	148	6	of	of	IN
cord-022290-p0l1kv6n	148	7	the	the	DT
cord-022290-p0l1kv6n	148	8	two	two	CD
cord-022290-p0l1kv6n	148	9	domain	domain	NN
cord-022290-p0l1kv6n	148	10	structure	structure	NN
cord-022290-p0l1kv6n	148	11	of	of	IN
cord-022290-p0l1kv6n	148	12	the	the	DT
cord-022290-p0l1kv6n	148	13	3C	3C	NNP
cord-022290-p0l1kv6n	148	14	proteinase	proteinase	NN
cord-022290-p0l1kv6n	148	15	is	be	VBZ
cord-022290-p0l1kv6n	148	16	fairly	fairly	RB
cord-022290-p0l1kv6n	148	17	well	well	RB
cord-022290-p0l1kv6n	148	18	conserved	conserved	JJ
cord-022290-p0l1kv6n	148	19	.	.	.
cord-022290-p0l1kv6n	149	1	Differences	difference	NNS
cord-022290-p0l1kv6n	149	2	between	between	IN
cord-022290-p0l1kv6n	149	3	the	the	DT
cord-022290-p0l1kv6n	149	4	various	various	JJ
cord-022290-p0l1kv6n	149	5	3C	3C	NNP
cord-022290-p0l1kv6n	149	6	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	149	7	manifest	manifest	NN
cord-022290-p0l1kv6n	149	8	in	in	IN
cord-022290-p0l1kv6n	149	9	the	the	DT
cord-022290-p0l1kv6n	149	10	length	length	NN
cord-022290-p0l1kv6n	149	11	of	of	IN
cord-022290-p0l1kv6n	149	12	the	the	DT
cord-022290-p0l1kv6n	149	13	secondary	secondary	JJ
cord-022290-p0l1kv6n	149	14	structure	structure	NN
cord-022290-p0l1kv6n	149	15	elements	element	NNS
cord-022290-p0l1kv6n	149	16	and	and	CC
cord-022290-p0l1kv6n	149	17	in	in	IN
cord-022290-p0l1kv6n	149	18	the	the	DT
cord-022290-p0l1kv6n	149	19	turns	turn	NNS
cord-022290-p0l1kv6n	149	20	and	and	CC
cord-022290-p0l1kv6n	149	21	loops	loop	NNS
cord-022290-p0l1kv6n	149	22	that	that	WDT
cord-022290-p0l1kv6n	149	23	connect	connect	VBP
cord-022290-p0l1kv6n	149	24	the	the	DT
cord-022290-p0l1kv6n	149	25	fl	fl	NNP
cord-022290-p0l1kv6n	149	26	-	-	HYPH
cord-022290-p0l1kv6n	149	27	strands	strand	NNS
cord-022290-p0l1kv6n	149	28	and	and	CC
cord-022290-p0l1kv6n	149	29	protrude	protrude	VB
cord-022290-p0l1kv6n	149	30	from	from	IN
cord-022290-p0l1kv6n	149	31	the	the	DT
cord-022290-p0l1kv6n	149	32	core	core	NN
cord-022290-p0l1kv6n	149	33	of	of	IN
cord-022290-p0l1kv6n	149	34	the	the	DT
cord-022290-p0l1kv6n	149	35	fl	fl	JJ
cord-022290-p0l1kv6n	149	36	-	-	HYPH
cord-022290-p0l1kv6n	149	37	barrel	barrel	NN
cord-022290-p0l1kv6n	149	38	domains	domain	NNS
cord-022290-p0l1kv6n	149	39	.	.	.
cord-022290-p0l1kv6n	150	1	In	in	IN
cord-022290-p0l1kv6n	150	2	spite	spite	NN
cord-022290-p0l1kv6n	150	3	of	of	IN
cord-022290-p0l1kv6n	150	4	being	be	VBG
cord-022290-p0l1kv6n	150	5	cysteine	cysteine	NN
cord-022290-p0l1kv6n	150	6	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	150	7	,	,	,
cord-022290-p0l1kv6n	150	8	the	the	DT
cord-022290-p0l1kv6n	150	9	3C	3C	NNP
cord-022290-p0l1kv6n	150	10	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	150	11	belong	belong	VBP
cord-022290-p0l1kv6n	150	12	structurally	structurally	RB
cord-022290-p0l1kv6n	150	13	to	to	IN
cord-022290-p0l1kv6n	150	14	the	the	DT
cord-022290-p0l1kv6n	150	15	superfamily	superfamily	NN
cord-022290-p0l1kv6n	150	16	of	of	IN
cord-022290-p0l1kv6n	150	17	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	150	18	-	-	HYPH
cord-022290-p0l1kv6n	150	19	like	like	JJ
cord-022290-p0l1kv6n	150	20	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	150	21	(	(	-LRB-
cord-022290-p0l1kv6n	150	22	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	150	23	and	and	CC
cord-022290-p0l1kv6n	150	24	Snijder	Snijder	NNP
cord-022290-p0l1kv6n	150	25	,	,	,
cord-022290-p0l1kv6n	150	26	1996	1996	CD
cord-022290-p0l1kv6n	150	27	)	)	-RRB-
cord-022290-p0l1kv6n	150	28	.	.	.
cord-022290-p0l1kv6n	151	1	The	the	DT
cord-022290-p0l1kv6n	151	2	structures	structure	NNS
cord-022290-p0l1kv6n	151	3	of	of	IN
cord-022290-p0l1kv6n	151	4	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	151	5	-	-	HYPH
cord-022290-p0l1kv6n	151	6	like	like	JJ
cord-022290-p0l1kv6n	151	7	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	151	8	are	be	VBP
cord-022290-p0l1kv6n	151	9	formed	form	VBN
cord-022290-p0l1kv6n	151	10	by	by	IN
cord-022290-p0l1kv6n	151	11	two	two	CD
cord-022290-p0l1kv6n	151	12	antiparallel	antiparallel	IN
cord-022290-p0l1kv6n	151	13	fl	fl	NNS
cord-022290-p0l1kv6n	151	14	-	-	HYPH
cord-022290-p0l1kv6n	151	15	barrels	barrel	NNS
cord-022290-p0l1kv6n	151	16	with	with	IN
cord-022290-p0l1kv6n	151	17	the	the	DT
cord-022290-p0l1kv6n	151	18	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	151	19	active	active	JJ
cord-022290-p0l1kv6n	151	20	site	site	NN
cord-022290-p0l1kv6n	151	21	at	at	IN
cord-022290-p0l1kv6n	151	22	the	the	DT
cord-022290-p0l1kv6n	151	23	domain	domain	NN
cord-022290-p0l1kv6n	151	24	interface	interface	NN
cord-022290-p0l1kv6n	151	25	.	.	.
cord-022290-p0l1kv6n	152	1	Both	both	DT
cord-022290-p0l1kv6n	152	2	domains	domain	NNS
cord-022290-p0l1kv6n	152	3	contribute	contribute	VBP
cord-022290-p0l1kv6n	152	4	to	to	IN
cord-022290-p0l1kv6n	152	5	the	the	DT
cord-022290-p0l1kv6n	152	6	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	152	7	residues	residue	NNS
cord-022290-p0l1kv6n	152	8	in	in	IN
cord-022290-p0l1kv6n	152	9	the	the	DT
cord-022290-p0l1kv6n	152	10	active	active	JJ
cord-022290-p0l1kv6n	152	11	site	site	NN
cord-022290-p0l1kv6n	152	12	.	.	.
cord-022290-p0l1kv6n	153	1	Both	both	DT
cord-022290-p0l1kv6n	153	2	domains	domain	NNS
cord-022290-p0l1kv6n	153	3	also	also	RB
cord-022290-p0l1kv6n	153	4	participate	participate	VBP
cord-022290-p0l1kv6n	153	5	in	in	IN
cord-022290-p0l1kv6n	153	6	the	the	DT
cord-022290-p0l1kv6n	153	7	binding	binding	NN
cord-022290-p0l1kv6n	153	8	of	of	IN
cord-022290-p0l1kv6n	153	9	peptide	peptide	NN
cord-022290-p0l1kv6n	153	10	substrates	substrate	NNS
cord-022290-p0l1kv6n	153	11	.	.	.
cord-022290-p0l1kv6n	154	1	The	the	DT
cord-022290-p0l1kv6n	154	2	N	n	CD
cord-022290-p0l1kv6n	154	3	-	-	HYPH
cord-022290-p0l1kv6n	154	4	terminal	terminal	NN
cord-022290-p0l1kv6n	154	5	domain	domain	NN
cord-022290-p0l1kv6n	154	6	is	be	VBZ
cord-022290-p0l1kv6n	154	7	mostly	mostly	RB
cord-022290-p0l1kv6n	154	8	involved	involve	VBN
cord-022290-p0l1kv6n	154	9	in	in	IN
cord-022290-p0l1kv6n	154	10	binding	bind	VBG
cord-022290-p0l1kv6n	154	11	the	the	DT
cord-022290-p0l1kv6n	154	12	substrate	substrate	NN
cord-022290-p0l1kv6n	154	13	residues	residue	NNS
cord-022290-p0l1kv6n	154	14	following	follow	VBG
cord-022290-p0l1kv6n	154	15	the	the	DT
cord-022290-p0l1kv6n	154	16	scissile	scissile	NNP
cord-022290-p0l1kv6n	154	17	peptide	peptide	NNP
cord-022290-p0l1kv6n	154	18	bond	bond	NN
cord-022290-p0l1kv6n	154	19	(	(	-LRB-
cord-022290-p0l1kv6n	154	20	P~	p~	DT
cord-022290-p0l1kv6n	154	21	to	to	IN
cord-022290-p0l1kv6n	154	22	P~	P~	NNP
cord-022290-p0l1kv6n	154	23	)	)	-RRB-
cord-022290-p0l1kv6n	154	24	whereas	whereas	IN
cord-022290-p0l1kv6n	154	25	the	the	DT
cord-022290-p0l1kv6n	154	26	C	C	NNP
cord-022290-p0l1kv6n	154	27	-	-	HYPH
cord-022290-p0l1kv6n	154	28	terminal	terminal	NN
cord-022290-p0l1kv6n	154	29	domain	domain	NN
cord-022290-p0l1kv6n	154	30	forms	form	VBZ
cord-022290-p0l1kv6n	154	31	the	the	DT
cord-022290-p0l1kv6n	154	32	specific	specific	JJ
cord-022290-p0l1kv6n	154	33	subsites	subsite	NNS
cord-022290-p0l1kv6n	154	34	for	for	IN
cord-022290-p0l1kv6n	154	35	the	the	DT
cord-022290-p0l1kv6n	154	36	substrate	substrate	JJ
cord-022290-p0l1kv6n	154	37	residues	residue	NNS
cord-022290-p0l1kv6n	154	38	preceding	precede	VBG
cord-022290-p0l1kv6n	154	39	the	the	DT
cord-022290-p0l1kv6n	154	40	scissile	scissile	NNP
cord-022290-p0l1kv6n	154	41	bond	bond	NN
cord-022290-p0l1kv6n	154	42	(	(	-LRB-
cord-022290-p0l1kv6n	154	43	P4	P4	NNP
cord-022290-p0l1kv6n	154	44	to	to	IN
cord-022290-p0l1kv6n	154	45	P1	P1	NNP
cord-022290-p0l1kv6n	154	46	)	)	-RRB-
cord-022290-p0l1kv6n	154	47	(	(	-LRB-
cord-022290-p0l1kv6n	154	48	Perona	Perona	NNP
cord-022290-p0l1kv6n	154	49	and	and	CC
cord-022290-p0l1kv6n	154	50	Craik	Craik	NNP
cord-022290-p0l1kv6n	154	51	,	,	,
cord-022290-p0l1kv6n	154	52	1995	1995	CD
cord-022290-p0l1kv6n	154	53	)	)	-RRB-
cord-022290-p0l1kv6n	154	54	.	.	.
cord-022290-p0l1kv6n	155	1	The	the	DT
cord-022290-p0l1kv6n	155	2	two	two	CD
cord-022290-p0l1kv6n	155	3	domains	domain	NNS
cord-022290-p0l1kv6n	155	4	of	of	IN
cord-022290-p0l1kv6n	155	5	the	the	DT
cord-022290-p0l1kv6n	155	6	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	155	7	-	-	HYPH
cord-022290-p0l1kv6n	155	8	like	like	JJ
cord-022290-p0l1kv6n	155	9	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	155	10	are	be	VBP
cord-022290-p0l1kv6n	155	11	usually	usually	RB
cord-022290-p0l1kv6n	155	12	described	describe	VBN
cord-022290-p0l1kv6n	155	13	as	as	IN
cord-022290-p0l1kv6n	155	14	six	six	CD
cord-022290-p0l1kv6n	155	15	-	-	HYPH
cord-022290-p0l1kv6n	155	16	stranded	stranded	JJ
cord-022290-p0l1kv6n	155	17	,	,	,
cord-022290-p0l1kv6n	155	18	antiparallel	antiparallel	IN
cord-022290-p0l1kv6n	155	19	fl	fl	NNS
cord-022290-p0l1kv6n	155	20	-	-	HYPH
cord-022290-p0l1kv6n	155	21	barrels	barrel	NNS
cord-022290-p0l1kv6n	155	22	,	,	,
cord-022290-p0l1kv6n	155	23	with	with	IN
cord-022290-p0l1kv6n	155	24	the	the	DT
cord-022290-p0l1kv6n	155	25	individual	individual	JJ
cord-022290-p0l1kv6n	155	26	fi	fi	NN
cord-022290-p0l1kv6n	155	27	-	-	HYPH
cord-022290-p0l1kv6n	155	28	strands	strand	NNS
cord-022290-p0l1kv6n	155	29	labeled	label	VBN
cord-022290-p0l1kv6n	155	30	aI	aI	NNP
cord-022290-p0l1kv6n	155	31	-	-	HYPH
cord-022290-p0l1kv6n	155	32	fl	fl	NNP
cord-022290-p0l1kv6n	155	33	and	and	CC
cord-022290-p0l1kv6n	155	34	alI	ali	JJ
cord-022290-p0l1kv6n	155	35	-	-	HYPH
cord-022290-p0l1kv6n	155	36	flI	fli	NN
cord-022290-p0l1kv6n	156	1	(	(	-LRB-
cord-022290-p0l1kv6n	156	2	Figs	fig	NNS
cord-022290-p0l1kv6n	156	3	.	.	.
cord-022290-p0l1kv6n	156	4	2	2	CD
cord-022290-p0l1kv6n	156	5	and	and	CC
cord-022290-p0l1kv6n	156	6	3	3	CD
cord-022290-p0l1kv6n	156	7	,	,	,
cord-022290-p0l1kv6n	156	8	see	see	VB
cord-022290-p0l1kv6n	156	9	color	color	NN
cord-022290-p0l1kv6n	156	10	plates	plate	NNS
cord-022290-p0l1kv6n	156	11	)	)	-RRB-
cord-022290-p0l1kv6n	156	12	.	.	.
cord-022290-p0l1kv6n	157	1	An	an	DT
cord-022290-p0l1kv6n	157	2	alternative	alternative	JJ
cord-022290-p0l1kv6n	157	3	description	description	NN
cord-022290-p0l1kv6n	157	4	of	of	IN
cord-022290-p0l1kv6n	157	5	the	the	DT
cord-022290-p0l1kv6n	157	6	fl	fl	NNP
cord-022290-p0l1kv6n	157	7	-	-	HYPH
cord-022290-p0l1kv6n	157	8	barrels	barrel	NNS
cord-022290-p0l1kv6n	157	9	is	be	VBZ
cord-022290-p0l1kv6n	157	10	that	that	DT
cord-022290-p0l1kv6n	157	11	of	of	IN
cord-022290-p0l1kv6n	157	12	a	a	DT
cord-022290-p0l1kv6n	157	13	sandwich	sandwich	NN
cord-022290-p0l1kv6n	157	14	of	of	IN
cord-022290-p0l1kv6n	157	15	two	two	CD
cord-022290-p0l1kv6n	157	16	orthogonal	orthogonal	JJ
cord-022290-p0l1kv6n	157	17	,	,	,
cord-022290-p0l1kv6n	157	18	four	four	CD
cord-022290-p0l1kv6n	157	19	-	-	HYPH
cord-022290-p0l1kv6n	157	20	stranded	stranded	JJ
cord-022290-p0l1kv6n	157	21	,	,	,
cord-022290-p0l1kv6n	157	22	antiparallel	antiparallel	IN
cord-022290-p0l1kv6n	157	23	fi	fi	NN
cord-022290-p0l1kv6n	157	24	-	-	HYPH
cord-022290-p0l1kv6n	157	25	sheets	sheet	NNS
cord-022290-p0l1kv6n	157	26	(	(	-LRB-
cord-022290-p0l1kv6n	157	27	Chotia	Chotia	NNP
cord-022290-p0l1kv6n	157	28	,	,	,
cord-022290-p0l1kv6n	157	29	1984	1984	CD
cord-022290-p0l1kv6n	157	30	)	)	-RRB-
cord-022290-p0l1kv6n	157	31	.	.	.
cord-022290-p0l1kv6n	158	1	The	the	DT
cord-022290-p0l1kv6n	158	2	fl	fl	NNP
cord-022290-p0l1kv6n	158	3	-	-	HYPH
cord-022290-p0l1kv6n	158	4	strands	strand	NNS
cord-022290-p0l1kv6n	158	5	,	,	,
cord-022290-p0l1kv6n	158	6	which	which	WDT
cord-022290-p0l1kv6n	158	7	form	form	VBP
cord-022290-p0l1kv6n	158	8	the	the	DT
cord-022290-p0l1kv6n	158	9	edge	edge	NN
cord-022290-p0l1kv6n	158	10	of	of	IN
cord-022290-p0l1kv6n	158	11	the	the	DT
cord-022290-p0l1kv6n	158	12	sheets	sheet	NNS
cord-022290-p0l1kv6n	158	13	,	,	,
cord-022290-p0l1kv6n	158	14	belong	belong	VBP
cord-022290-p0l1kv6n	158	15	to	to	IN
cord-022290-p0l1kv6n	158	16	both	both	DT
cord-022290-p0l1kv6n	158	17	sheets	sheet	NNS
cord-022290-p0l1kv6n	158	18	and	and	CC
cord-022290-p0l1kv6n	158	19	continue	continue	VB
cord-022290-p0l1kv6n	158	20	,	,	,
cord-022290-p0l1kv6n	158	21	sometimes	sometimes	RB
cord-022290-p0l1kv6n	158	22	uninterrupted	uninterrupted	JJ
cord-022290-p0l1kv6n	158	23	,	,	,
cord-022290-p0l1kv6n	158	24	from	from	IN
cord-022290-p0l1kv6n	158	25	one	one	CD
cord-022290-p0l1kv6n	158	26	sheet	sheet	NN
cord-022290-p0l1kv6n	158	27	to	to	IN
cord-022290-p0l1kv6n	158	28	the	the	DT
cord-022290-p0l1kv6n	158	29	other	other	JJ
cord-022290-p0l1kv6n	158	30	.	.	.
cord-022290-p0l1kv6n	159	1	As	as	IN
cord-022290-p0l1kv6n	159	2	a	a	DT
cord-022290-p0l1kv6n	159	3	result	result	NN
cord-022290-p0l1kv6n	159	4	the	the	DT
cord-022290-p0l1kv6n	159	5	two	two	CD
cord-022290-p0l1kv6n	159	6	corners	corner	NNS
cord-022290-p0l1kv6n	159	7	of	of	IN
cord-022290-p0l1kv6n	159	8	the	the	DT
cord-022290-p0l1kv6n	159	9	"	"	``
cord-022290-p0l1kv6n	159	10	fl	fl	NNP
cord-022290-p0l1kv6n	159	11	-	-	HYPH
cord-022290-p0l1kv6n	159	12	sandwich	sandwich	NN
cord-022290-p0l1kv6n	159	13	,	,	,
cord-022290-p0l1kv6n	159	14	"	"	''
cord-022290-p0l1kv6n	159	15	which	which	WDT
cord-022290-p0l1kv6n	159	16	are	be	VBP
cord-022290-p0l1kv6n	159	17	formed	form	VBN
cord-022290-p0l1kv6n	159	18	by	by	IN
cord-022290-p0l1kv6n	159	19	the	the	DT
cord-022290-p0l1kv6n	159	20	edge	edge	NN
cord-022290-p0l1kv6n	159	21	-	-	HYPH
cord-022290-p0l1kv6n	159	22	strands	strand	NNS
cord-022290-p0l1kv6n	159	23	,	,	,
cord-022290-p0l1kv6n	159	24	are	be	VBP
cord-022290-p0l1kv6n	159	25	closed	close	VBN
cord-022290-p0l1kv6n	159	26	,	,	,
cord-022290-p0l1kv6n	159	27	while	while	IN
cord-022290-p0l1kv6n	159	28	the	the	DT
cord-022290-p0l1kv6n	159	29	other	other	JJ
cord-022290-p0l1kv6n	159	30	two	two	CD
cord-022290-p0l1kv6n	159	31	corners	corner	NNS
cord-022290-p0l1kv6n	159	32	are	be	VBP
cord-022290-p0l1kv6n	159	33	splayed	splay	VBN
cord-022290-p0l1kv6n	159	34	(	(	-LRB-
cord-022290-p0l1kv6n	159	35	Chotia	Chotia	NNP
cord-022290-p0l1kv6n	159	36	,	,	,
cord-022290-p0l1kv6n	159	37	1984	1984	CD
cord-022290-p0l1kv6n	159	38	)	)	-RRB-
cord-022290-p0l1kv6n	159	39	.	.	.
cord-022290-p0l1kv6n	160	1	In	in	IN
cord-022290-p0l1kv6n	160	2	both	both	DT
cord-022290-p0l1kv6n	160	3	fl	fl	JJ
cord-022290-p0l1kv6n	160	4	-	-	HYPH
cord-022290-p0l1kv6n	160	5	barrel	barrel	NN
cord-022290-p0l1kv6n	160	6	domains	domain	NNS
cord-022290-p0l1kv6n	160	7	of	of	IN
cord-022290-p0l1kv6n	160	8	the	the	DT
cord-022290-p0l1kv6n	160	9	HAV	HAV	NNP
cord-022290-p0l1kv6n	160	10	3C	3c	NN
cord-022290-p0l1kv6n	160	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	160	12	one	one	CD
cord-022290-p0l1kv6n	160	13	of	of	IN
cord-022290-p0l1kv6n	160	14	the	the	DT
cord-022290-p0l1kv6n	160	15	edge	edge	NN
cord-022290-p0l1kv6n	160	16	strands	strand	NNS
cord-022290-p0l1kv6n	160	17	is	be	VBZ
cord-022290-p0l1kv6n	160	18	interrupted	interrupt	VBN
cord-022290-p0l1kv6n	160	19	while	while	IN
cord-022290-p0l1kv6n	160	20	the	the	DT
cord-022290-p0l1kv6n	160	21	other	other	JJ
cord-022290-p0l1kv6n	160	22	continues	continue	VBZ
cord-022290-p0l1kv6n	160	23	from	from	IN
cord-022290-p0l1kv6n	160	24	one	one	CD
cord-022290-p0l1kv6n	160	25	fl	fl	NNP
cord-022290-p0l1kv6n	160	26	-	-	HYPH
cord-022290-p0l1kv6n	160	27	sheet	sheet	NN
cord-022290-p0l1kv6n	160	28	to	to	IN
cord-022290-p0l1kv6n	160	29	the	the	DT
cord-022290-p0l1kv6n	160	30	other	other	JJ
cord-022290-p0l1kv6n	161	1	(	(	-LRB-
cord-022290-p0l1kv6n	161	2	Fig	Fig	NNP
cord-022290-p0l1kv6n	161	3	.	.	NNP
cord-022290-p0l1kv6n	161	4	2	2	CD
cord-022290-p0l1kv6n	161	5	)	)	-RRB-
cord-022290-p0l1kv6n	162	1	(	(	-LRB-
cord-022290-p0l1kv6n	162	2	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	162	3	et	et	NNP
cord-022290-p0l1kv6n	162	4	al	al	NNP
cord-022290-p0l1kv6n	162	5	.	.	NNP
cord-022290-p0l1kv6n	162	6	,	,	,
cord-022290-p0l1kv6n	162	7	1997	1997	CD
cord-022290-p0l1kv6n	162	8	)	)	-RRB-
cord-022290-p0l1kv6n	162	9	.	.	.
cord-022290-p0l1kv6n	163	1	In	in	IN
cord-022290-p0l1kv6n	163	2	the	the	DT
cord-022290-p0l1kv6n	163	3	N	n	CD
cord-022290-p0l1kv6n	163	4	-	-	HYPH
cord-022290-p0l1kv6n	163	5	terminal	terminal	NN
cord-022290-p0l1kv6n	163	6	domain	domain	NN
cord-022290-p0l1kv6n	163	7	fi	fi	NN
cord-022290-p0l1kv6n	163	8	-	-	HYPH
cord-022290-p0l1kv6n	163	9	strand	strand	NN
cord-022290-p0l1kv6n	163	10	el	el	NNP
cord-022290-p0l1kv6n	163	11	is	be	VBZ
cord-022290-p0l1kv6n	163	12	interrupted	interrupt	VBN
cord-022290-p0l1kv6n	163	13	by	by	IN
cord-022290-p0l1kv6n	163	14	a	a	DT
cord-022290-p0l1kv6n	163	15	single	single	JJ
cord-022290-p0l1kv6n	163	16	helical	helical	JJ
cord-022290-p0l1kv6n	163	17	turn	turn	NN
cord-022290-p0l1kv6n	163	18	.	.	.
cord-022290-p0l1kv6n	164	1	fl	fl	JJ
cord-022290-p0l1kv6n	164	2	-	-	HYPH
cord-022290-p0l1kv6n	164	3	strand	strand	NN
cord-022290-p0l1kv6n	164	4	bI	bI	NNP
cord-022290-p0l1kv6n	164	5	forms	form	VBZ
cord-022290-p0l1kv6n	164	6	a	a	DT
cord-022290-p0l1kv6n	164	7	fi	fi	NN
cord-022290-p0l1kv6n	164	8	-	-	NN
cord-022290-p0l1kv6n	164	9	bulge	bulge	NN
cord-022290-p0l1kv6n	164	10	at	at	IN
cord-022290-p0l1kv6n	164	11	Val	Val	NNP
cord-022290-p0l1kv6n	164	12	28	28	CD
cord-022290-p0l1kv6n	164	13	,	,	,
cord-022290-p0l1kv6n	164	14	allowing	allow	VBG
cord-022290-p0l1kv6n	164	15	it	-PRON-	PRP
cord-022290-p0l1kv6n	164	16	to	to	TO
cord-022290-p0l1kv6n	164	17	bend	bend	VB
cord-022290-p0l1kv6n	164	18	from	from	IN
cord-022290-p0l1kv6n	164	19	one	one	CD
cord-022290-p0l1kv6n	164	20	fl	fl	NNP
cord-022290-p0l1kv6n	164	21	-	-	HYPH
cord-022290-p0l1kv6n	164	22	sheet	sheet	NN
cord-022290-p0l1kv6n	164	23	to	to	IN
cord-022290-p0l1kv6n	164	24	the	the	DT
cord-022290-p0l1kv6n	164	25	other	other	JJ
cord-022290-p0l1kv6n	164	26	.	.	.
cord-022290-p0l1kv6n	165	1	The	the	DT
cord-022290-p0l1kv6n	165	2	residue	residue	NN
cord-022290-p0l1kv6n	165	3	Val	Val	NNP
cord-022290-p0l1kv6n	165	4	28	28	CD
cord-022290-p0l1kv6n	165	5	is	be	VBZ
cord-022290-p0l1kv6n	165	6	involved	involve	VBN
cord-022290-p0l1kv6n	165	7	in	in	IN
cord-022290-p0l1kv6n	165	8	the	the	DT
cord-022290-p0l1kv6n	165	9	binding	binding	NN
cord-022290-p0l1kv6n	165	10	of	of	IN
cord-022290-p0l1kv6n	165	11	peptide	peptide	NN
cord-022290-p0l1kv6n	165	12	substrates	substrate	NNS
cord-022290-p0l1kv6n	165	13	by	by	IN
cord-022290-p0l1kv6n	165	14	HAV	HAV	NNP
cord-022290-p0l1kv6n	165	15	3C.	3c.	CD
cord-022290-p0l1kv6n	166	1	In	in	IN
cord-022290-p0l1kv6n	166	2	the	the	DT
cord-022290-p0l1kv6n	166	3	C	c	NN
cord-022290-p0l1kv6n	166	4	-	-	HYPH
cord-022290-p0l1kv6n	166	5	terminal	terminal	NN
cord-022290-p0l1kv6n	166	6	domain	domain	NN
cord-022290-p0l1kv6n	166	7	of	of	IN
cord-022290-p0l1kv6n	166	8	HAV	HAV	NNP
cord-022290-p0l1kv6n	166	9	3C	3c	NN
cord-022290-p0l1kv6n	166	10	the	the	DT
cord-022290-p0l1kv6n	166	11	blI	bli	NN
cord-022290-p0l1kv6n	166	12	strand	strand	NN
cord-022290-p0l1kv6n	166	13	is	be	VBZ
cord-022290-p0l1kv6n	166	14	interrupted	interrupt	VBN
cord-022290-p0l1kv6n	166	15	by	by	IN
cord-022290-p0l1kv6n	166	16	a	a	DT
cord-022290-p0l1kv6n	166	17	short	short	JJ
cord-022290-p0l1kv6n	166	18	stretch	stretch	NN
cord-022290-p0l1kv6n	166	19	of	of	IN
cord-022290-p0l1kv6n	166	20	random	random	JJ
cord-022290-p0l1kv6n	166	21	coil	coil	NN
cord-022290-p0l1kv6n	166	22	structure	structure	NN
cord-022290-p0l1kv6n	166	23	,	,	,
cord-022290-p0l1kv6n	166	24	whereas	whereas	IN
cord-022290-p0l1kv6n	166	25	the	the	DT
cord-022290-p0l1kv6n	166	26	eli	eli	NNP
cord-022290-p0l1kv6n	166	27	strand	strand	NN
cord-022290-p0l1kv6n	166	28	continues	continue	VBZ
cord-022290-p0l1kv6n	166	29	from	from	IN
cord-022290-p0l1kv6n	166	30	one	one	CD
cord-022290-p0l1kv6n	166	31	sheet	sheet	NN
cord-022290-p0l1kv6n	166	32	to	to	IN
cord-022290-p0l1kv6n	166	33	the	the	DT
cord-022290-p0l1kv6n	166	34	other	other	JJ
cord-022290-p0l1kv6n	166	35	.	.	.
cord-022290-p0l1kv6n	167	1	There	there	EX
cord-022290-p0l1kv6n	167	2	are	be	VBP
cord-022290-p0l1kv6n	167	3	seven	seven	CD
cord-022290-p0l1kv6n	167	4	defined	define	VBN
cord-022290-p0l1kv6n	167	5	fl	fl	NNP
cord-022290-p0l1kv6n	167	6	-	-	HYPH
cord-022290-p0l1kv6n	167	7	strands	strand	NNS
cord-022290-p0l1kv6n	167	8	in	in	IN
cord-022290-p0l1kv6n	167	9	both	both	DT
cord-022290-p0l1kv6n	167	10	of	of	IN
cord-022290-p0l1kv6n	167	11	the	the	DT
cord-022290-p0l1kv6n	167	12	domains	domain	NNS
cord-022290-p0l1kv6n	167	13	of	of	IN
cord-022290-p0l1kv6n	167	14	HAV	HAV	NNP
cord-022290-p0l1kv6n	167	15	3C.	3c.	CD
cord-022290-p0l1kv6n	168	1	In	in	IN
cord-022290-p0l1kv6n	168	2	the	the	DT
cord-022290-p0l1kv6n	168	3	two	two	CD
cord-022290-p0l1kv6n	168	4	smaller	small	JJR
cord-022290-p0l1kv6n	168	5	fi	fi	NN
cord-022290-p0l1kv6n	168	6	-	-	HYPH
cord-022290-p0l1kv6n	168	7	barrels	barrel	NNS
cord-022290-p0l1kv6n	168	8	,	,	,
cord-022290-p0l1kv6n	168	9	which	which	WDT
cord-022290-p0l1kv6n	168	10	form	form	VBP
cord-022290-p0l1kv6n	168	11	the	the	DT
cord-022290-p0l1kv6n	168	12	domains	domain	NNS
cord-022290-p0l1kv6n	168	13	of	of	IN
cord-022290-p0l1kv6n	168	14	the	the	DT
cord-022290-p0l1kv6n	168	15	polio	polio	NN
cord-022290-p0l1kv6n	168	16	3C	3C	NNP
cord-022290-p0l1kv6n	168	17	,	,	,
cord-022290-p0l1kv6n	168	18	the	the	DT
cord-022290-p0l1kv6n	168	19	edge	edge	NN
cord-022290-p0l1kv6n	168	20	strands	strand	NNS
cord-022290-p0l1kv6n	168	21	continue	continue	VBP
cord-022290-p0l1kv6n	168	22	uninterrupted	uninterrupted	JJ
cord-022290-p0l1kv6n	168	23	from	from	IN
cord-022290-p0l1kv6n	168	24	one	one	CD
cord-022290-p0l1kv6n	168	25	sheet	sheet	NN
cord-022290-p0l1kv6n	168	26	to	to	IN
cord-022290-p0l1kv6n	168	27	the	the	DT
cord-022290-p0l1kv6n	168	28	other	other	JJ
cord-022290-p0l1kv6n	168	29	(	(	-LRB-
cord-022290-p0l1kv6n	168	30	Fig	Fig	NNP
cord-022290-p0l1kv6n	168	31	.	.	.
cord-022290-p0l1kv6n	168	32	3	3	CD
cord-022290-p0l1kv6n	168	33	)	)	-RRB-
cord-022290-p0l1kv6n	168	34	.	.	.
cord-022290-p0l1kv6n	169	1	There	there	EX
cord-022290-p0l1kv6n	169	2	are	be	VBP
cord-022290-p0l1kv6n	169	3	six	six	CD
cord-022290-p0l1kv6n	169	4	defined	define	VBN
cord-022290-p0l1kv6n	169	5	fl	fl	NNP
cord-022290-p0l1kv6n	169	6	-	-	HYPH
cord-022290-p0l1kv6n	169	7	strands	strand	NNS
cord-022290-p0l1kv6n	169	8	in	in	IN
cord-022290-p0l1kv6n	169	9	each	each	DT
cord-022290-p0l1kv6n	169	10	domain	domain	NN
cord-022290-p0l1kv6n	169	11	of	of	IN
cord-022290-p0l1kv6n	169	12	the	the	DT
cord-022290-p0l1kv6n	169	13	polio	polio	NN
cord-022290-p0l1kv6n	169	14	3C	3C	NNP
cord-022290-p0l1kv6n	169	15	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	169	16	.	.	.
cord-022290-p0l1kv6n	170	1	Two	two	CD
cord-022290-p0l1kv6n	170	2	of	of	IN
cord-022290-p0l1kv6n	170	3	the	the	DT
cord-022290-p0l1kv6n	170	4	fl	fl	NNP
cord-022290-p0l1kv6n	170	5	-	-	HYPH
cord-022290-p0l1kv6n	170	6	strands	strand	NNS
cord-022290-p0l1kv6n	170	7	,	,	,
cord-022290-p0l1kv6n	170	8	blI	bli	NN
cord-022290-p0l1kv6n	170	9	and	and	CC
cord-022290-p0l1kv6n	170	10	clI	clI	NNS
cord-022290-p0l1kv6n	170	11	,	,	,
cord-022290-p0l1kv6n	170	12	of	of	IN
cord-022290-p0l1kv6n	170	13	the	the	DT
cord-022290-p0l1kv6n	170	14	C	c	NN
cord-022290-p0l1kv6n	170	15	-	-	HYPH
cord-022290-p0l1kv6n	170	16	terminal	terminal	NN
cord-022290-p0l1kv6n	170	17	domain	domain	NN
cord-022290-p0l1kv6n	170	18	of	of	IN
cord-022290-p0l1kv6n	170	19	the	the	DT
cord-022290-p0l1kv6n	170	20	3C	3C	NNP
cord-022290-p0l1kv6n	170	21	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	170	22	are	be	VBP
cord-022290-p0l1kv6n	170	23	extended	extend	VBN
cord-022290-p0l1kv6n	170	24	past	past	IN
cord-022290-p0l1kv6n	170	25	the	the	DT
cord-022290-p0l1kv6n	170	26	C	C	NNP
cord-022290-p0l1kv6n	170	27	-	-	HYPH
cord-022290-p0l1kv6n	170	28	terminal	terminal	NNP
cord-022290-p0l1kv6n	170	29	fl	fl	JJ
cord-022290-p0l1kv6n	170	30	-	-	HYPH
cord-022290-p0l1kv6n	170	31	barrel	barrel	NN
cord-022290-p0l1kv6n	170	32	(	(	-LRB-
cord-022290-p0l1kv6n	170	33	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	170	34	et	et	NNP
cord-022290-p0l1kv6n	170	35	al	al	NNP
cord-022290-p0l1kv6n	170	36	.	.	NNP
cord-022290-p0l1kv6n	170	37	,	,	,
cord-022290-p0l1kv6n	170	38	1997	1997	CD
cord-022290-p0l1kv6n	170	39	)	)	-RRB-
cord-022290-p0l1kv6n	170	40	.	.	.
cord-022290-p0l1kv6n	171	1	From	from	IN
cord-022290-p0l1kv6n	171	2	the	the	DT
cord-022290-p0l1kv6n	171	3	point	point	NN
cord-022290-p0l1kv6n	171	4	where	where	WRB
cord-022290-p0l1kv6n	171	5	the	the	DT
cord-022290-p0l1kv6n	171	6	two	two	CD
cord-022290-p0l1kv6n	171	7	strands	strand	NNS
cord-022290-p0l1kv6n	171	8	are	be	VBP
cord-022290-p0l1kv6n	171	9	no	no	RB
cord-022290-p0l1kv6n	171	10	longer	long	JJR
cord-022290-p0l1kv6n	171	11	part	part	NN
cord-022290-p0l1kv6n	171	12	of	of	IN
cord-022290-p0l1kv6n	171	13	the	the	DT
cord-022290-p0l1kv6n	171	14	fl	fl	JJ
cord-022290-p0l1kv6n	171	15	-	-	HYPH
cord-022290-p0l1kv6n	171	16	barrel	barrel	NN
cord-022290-p0l1kv6n	171	17	they	-PRON-	PRP
cord-022290-p0l1kv6n	171	18	form	form	VBP
cord-022290-p0l1kv6n	171	19	an	an	DT
cord-022290-p0l1kv6n	171	20	antiparallel	antiparallel	NN
cord-022290-p0l1kv6n	171	21	,	,	,
cord-022290-p0l1kv6n	171	22	two	two	CD
cord-022290-p0l1kv6n	171	23	-	-	HYPH
cord-022290-p0l1kv6n	171	24	stranded	strand	VBN
cord-022290-p0l1kv6n	171	25	fl	fl	NNP
cord-022290-p0l1kv6n	171	26	-	-	HYPH
cord-022290-p0l1kv6n	171	27	ribbon	ribbon	NN
cord-022290-p0l1kv6n	171	28	(	(	-LRB-
cord-022290-p0l1kv6n	171	29	light	light	JJ
cord-022290-p0l1kv6n	171	30	gray	gray	NN
cord-022290-p0l1kv6n	171	31	in	in	IN
cord-022290-p0l1kv6n	171	32	Figs	Figs	NNP
cord-022290-p0l1kv6n	171	33	.	.	.
cord-022290-p0l1kv6n	171	34	2	2	CD
cord-022290-p0l1kv6n	171	35	and	and	CC
cord-022290-p0l1kv6n	171	36	3	3	CD
cord-022290-p0l1kv6n	171	37	)	)	-RRB-
cord-022290-p0l1kv6n	171	38	.	.	.
cord-022290-p0l1kv6n	172	1	A	a	DT
cord-022290-p0l1kv6n	172	2	defined	define	VBN
cord-022290-p0l1kv6n	172	3	fl	fl	NNP
cord-022290-p0l1kv6n	172	4	-	-	HYPH
cord-022290-p0l1kv6n	172	5	bulge	bulge	NNP
cord-022290-p0l1kv6n	172	6	introduces	introduce	VBZ
cord-022290-p0l1kv6n	172	7	a	a	DT
cord-022290-p0l1kv6n	172	8	bend	bend	NN
cord-022290-p0l1kv6n	172	9	into	into	IN
cord-022290-p0l1kv6n	172	10	this	this	DT
cord-022290-p0l1kv6n	172	11	fl	fl	JJ
cord-022290-p0l1kv6n	172	12	-	-	HYPH
cord-022290-p0l1kv6n	172	13	ribbon	ribbon	NN
cord-022290-p0l1kv6n	172	14	,	,	,
cord-022290-p0l1kv6n	172	15	which	which	WDT
cord-022290-p0l1kv6n	172	16	causes	cause	VBZ
cord-022290-p0l1kv6n	172	17	it	-PRON-	PRP
cord-022290-p0l1kv6n	172	18	to	to	TO
cord-022290-p0l1kv6n	172	19	curl	curl	VB
cord-022290-p0l1kv6n	172	20	back	back	RB
cord-022290-p0l1kv6n	172	21	toward	toward	IN
cord-022290-p0l1kv6n	172	22	the	the	DT
cord-022290-p0l1kv6n	172	23	active	active	JJ
cord-022290-p0l1kv6n	172	24	site	site	NN
cord-022290-p0l1kv6n	172	25	.	.	.
cord-022290-p0l1kv6n	173	1	The	the	DT
cord-022290-p0l1kv6n	173	2	longer	long	JJR
cord-022290-p0l1kv6n	173	3	fl	fl	NN
cord-022290-p0l1kv6n	173	4	-	-	HYPH
cord-022290-p0l1kv6n	173	5	ribbon	ribbon	NN
cord-022290-p0l1kv6n	173	6	in	in	IN
cord-022290-p0l1kv6n	173	7	the	the	DT
cord-022290-p0l1kv6n	173	8	HAV	HAV	NNP
cord-022290-p0l1kv6n	173	9	3C	3c	NN
cord-022290-p0l1kv6n	173	10	proteinase	proteinase	NN
cord-022290-p0l1kv6n	173	11	contributes	contribute	VBZ
cord-022290-p0l1kv6n	173	12	to	to	IN
cord-022290-p0l1kv6n	173	13	the	the	DT
cord-022290-p0l1kv6n	173	14	residues	residue	NNS
cord-022290-p0l1kv6n	173	15	involved	involve	VBN
cord-022290-p0l1kv6n	173	16	in	in	IN
cord-022290-p0l1kv6n	173	17	the	the	DT
cord-022290-p0l1kv6n	173	18	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	173	19	mechanism	mechanism	NN
cord-022290-p0l1kv6n	173	20	and	and	CC
cord-022290-p0l1kv6n	173	21	also	also	RB
cord-022290-p0l1kv6n	173	22	to	to	IN
cord-022290-p0l1kv6n	173	23	the	the	DT
cord-022290-p0l1kv6n	173	24	binding	binding	NN
cord-022290-p0l1kv6n	173	25	of	of	IN
cord-022290-p0l1kv6n	173	26	peptide	peptide	NN
cord-022290-p0l1kv6n	173	27	substrates	substrate	NNS
cord-022290-p0l1kv6n	173	28	(	(	-LRB-
cord-022290-p0l1kv6n	173	29	see	see	VB
cord-022290-p0l1kv6n	173	30	below	below	RB
cord-022290-p0l1kv6n	173	31	)	)	-RRB-
cord-022290-p0l1kv6n	173	32	.	.	.
cord-022290-p0l1kv6n	174	1	Because	because	IN
cord-022290-p0l1kv6n	174	2	the	the	DT
cord-022290-p0l1kv6n	174	3	fl	fl	NNP
cord-022290-p0l1kv6n	174	4	-	-	HYPH
cord-022290-p0l1kv6n	174	5	ribbon	ribbon	NN
cord-022290-p0l1kv6n	174	6	is	be	VBZ
cord-022290-p0l1kv6n	174	7	shorter	short	JJR
cord-022290-p0l1kv6n	174	8	in	in	IN
cord-022290-p0l1kv6n	174	9	the	the	DT
cord-022290-p0l1kv6n	174	10	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	174	11	3C	3c	NN
cord-022290-p0l1kv6n	174	12	,	,	,
cord-022290-p0l1kv6n	174	13	it	-PRON-	PRP
cord-022290-p0l1kv6n	174	14	only	only	RB
cord-022290-p0l1kv6n	174	15	contributes	contribute	VBZ
cord-022290-p0l1kv6n	174	16	to	to	IN
cord-022290-p0l1kv6n	174	17	the	the	DT
cord-022290-p0l1kv6n	174	18	P4	P4	NNP
cord-022290-p0l1kv6n	174	19	binding	bind	VBG
cord-022290-p0l1kv6n	174	20	pocket	pocket	NN
cord-022290-p0l1kv6n	174	21	and	and	CC
cord-022290-p0l1kv6n	174	22	the	the	DT
cord-022290-p0l1kv6n	174	23	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	174	24	active	active	JJ
cord-022290-p0l1kv6n	174	25	site	site	NN
cord-022290-p0l1kv6n	174	26	of	of	IN
cord-022290-p0l1kv6n	174	27	polio	polio	NNP
cord-022290-p0l1kv6n	174	28	3C	3C	NNP
cord-022290-p0l1kv6n	175	1	is	be	VBZ
cord-022290-p0l1kv6n	175	2	much	much	RB
cord-022290-p0l1kv6n	175	3	more	more	RBR
cord-022290-p0l1kv6n	175	4	accessible	accessible	JJ
cord-022290-p0l1kv6n	175	5	.	.	.
cord-022290-p0l1kv6n	176	1	This	this	DT
cord-022290-p0l1kv6n	176	2	fl	fl	NNP
cord-022290-p0l1kv6n	176	3	-	-	HYPH
cord-022290-p0l1kv6n	176	4	ribbon	ribbon	NN
cord-022290-p0l1kv6n	176	5	is	be	VBZ
cord-022290-p0l1kv6n	176	6	a	a	DT
cord-022290-p0l1kv6n	176	7	unique	unique	JJ
cord-022290-p0l1kv6n	176	8	feature	feature	NN
cord-022290-p0l1kv6n	176	9	of	of	IN
cord-022290-p0l1kv6n	176	10	the	the	DT
cord-022290-p0l1kv6n	176	11	3C	3c	NN
cord-022290-p0l1kv6n	176	12	proteinase	proteinase	NN
cord-022290-p0l1kv6n	176	13	and	and	CC
cord-022290-p0l1kv6n	176	14	replaces	replace	VBZ
cord-022290-p0l1kv6n	176	15	the	the	DT
cord-022290-p0l1kv6n	176	16	"	"	``
cord-022290-p0l1kv6n	176	17	methionine	methionine	NN
cord-022290-p0l1kv6n	176	18	loop	loop	NN
cord-022290-p0l1kv6n	176	19	"	"	''
cord-022290-p0l1kv6n	176	20	of	of	IN
cord-022290-p0l1kv6n	176	21	the	the	DT
cord-022290-p0l1kv6n	176	22	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	176	23	-	-	HYPH
cord-022290-p0l1kv6n	176	24	like	like	JJ
cord-022290-p0l1kv6n	176	25	serine	serine	NN
cord-022290-p0l1kv6n	176	26	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	176	27	.	.	.
cord-022290-p0l1kv6n	177	1	The	the	DT
cord-022290-p0l1kv6n	177	2	corresponding	corresponding	JJ
cord-022290-p0l1kv6n	177	3	topological	topological	JJ
cord-022290-p0l1kv6n	177	4	feature	feature	NN
cord-022290-p0l1kv6n	177	5	is	be	VBZ
cord-022290-p0l1kv6n	177	6	somewhat	somewhat	RB
cord-022290-p0l1kv6n	177	7	similar	similar	JJ
cord-022290-p0l1kv6n	177	8	,	,	,
cord-022290-p0l1kv6n	177	9	but	but	CC
cord-022290-p0l1kv6n	177	10	smaller	small	JJR
cord-022290-p0l1kv6n	177	11	,	,	,
cord-022290-p0l1kv6n	177	12	in	in	IN
cord-022290-p0l1kv6n	177	13	some	some	DT
cord-022290-p0l1kv6n	177	14	bacterial	bacterial	JJ
cord-022290-p0l1kv6n	177	15	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	177	16	(	(	-LRB-
cord-022290-p0l1kv6n	177	17	e.g.	e.g.	RB
cord-022290-p0l1kv6n	177	18	,	,	,
cord-022290-p0l1kv6n	177	19	cr	cr	JJ
cord-022290-p0l1kv6n	177	20	-	-	JJ
cord-022290-p0l1kv6n	177	21	lytic	lytic	JJ
cord-022290-p0l1kv6n	177	22	proteinase	proteinase	NN
cord-022290-p0l1kv6n	177	23	;	;	:
cord-022290-p0l1kv6n	177	24	Fujinaga	Fujinaga	NNP
cord-022290-p0l1kv6n	177	25	et	et	NNP
cord-022290-p0l1kv6n	177	26	al	al	NNP
cord-022290-p0l1kv6n	177	27	.	.	NNP
cord-022290-p0l1kv6n	177	28	,	,	,
cord-022290-p0l1kv6n	177	29	1985	1985	CD
cord-022290-p0l1kv6n	177	30	)	)	-RRB-
cord-022290-p0l1kv6n	177	31	.	.	.
cord-022290-p0l1kv6n	178	1	There	there	EX
cord-022290-p0l1kv6n	178	2	are	be	VBP
cord-022290-p0l1kv6n	178	3	helices	helix	NNS
cord-022290-p0l1kv6n	178	4	at	at	IN
cord-022290-p0l1kv6n	178	5	the	the	DT
cord-022290-p0l1kv6n	178	6	N	N	NNP
cord-022290-p0l1kv6n	178	7	-	-	HYPH
cord-022290-p0l1kv6n	178	8	and	and	CC
cord-022290-p0l1kv6n	178	9	C	C	NNP
cord-022290-p0l1kv6n	178	10	-	-	HYPH
cord-022290-p0l1kv6n	178	11	termini	termini	NNP
cord-022290-p0l1kv6n	178	12	of	of	IN
cord-022290-p0l1kv6n	178	13	the	the	DT
cord-022290-p0l1kv6n	178	14	3C	3C	NNP
cord-022290-p0l1kv6n	178	15	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	178	16	.	.	.
cord-022290-p0l1kv6n	179	1	The	the	DT
cord-022290-p0l1kv6n	179	2	N	n	CD
cord-022290-p0l1kv6n	179	3	-	-	HYPH
cord-022290-p0l1kv6n	179	4	terminal	terminal	NN
cord-022290-p0l1kv6n	179	5	helix	helix	NN
cord-022290-p0l1kv6n	179	6	packs	pack	NNS
cord-022290-p0l1kv6n	179	7	against	against	IN
cord-022290-p0l1kv6n	179	8	the	the	DT
cord-022290-p0l1kv6n	179	9	C	C	NNP
cord-022290-p0l1kv6n	179	10	-	-	HYPH
cord-022290-p0l1kv6n	179	11	terminal	terminal	NN
cord-022290-p0l1kv6n	179	12	]	]	-RRB-
cord-022290-p0l1kv6n	179	13	3-barrel	3-barrel	CD
cord-022290-p0l1kv6n	179	14	and	and	CC
cord-022290-p0l1kv6n	179	15	the	the	DT
cord-022290-p0l1kv6n	179	16	C	C	NNP
cord-022290-p0l1kv6n	179	17	-	-	HYPH
cord-022290-p0l1kv6n	179	18	terminal	terminal	NN
cord-022290-p0l1kv6n	179	19	helix	helix	NN
cord-022290-p0l1kv6n	179	20	packs	pack	NNS
cord-022290-p0l1kv6n	179	21	against	against	IN
cord-022290-p0l1kv6n	179	22	the	the	DT
cord-022290-p0l1kv6n	179	23	surface	surface	NN
cord-022290-p0l1kv6n	179	24	of	of	IN
cord-022290-p0l1kv6n	179	25	the	the	DT
cord-022290-p0l1kv6n	179	26	N	n	CD
cord-022290-p0l1kv6n	179	27	-	-	HYPH
cord-022290-p0l1kv6n	179	28	terminal	terminal	NN
cord-022290-p0l1kv6n	179	29	domain	domain	NN
cord-022290-p0l1kv6n	179	30	.	.	.
cord-022290-p0l1kv6n	180	1	The	the	DT
cord-022290-p0l1kv6n	180	2	two	two	CD
cord-022290-p0l1kv6n	180	3	helices	helix	NNS
cord-022290-p0l1kv6n	180	4	stabilize	stabilize	VBP
cord-022290-p0l1kv6n	180	5	the	the	DT
cord-022290-p0l1kv6n	180	6	structure	structure	NN
cord-022290-p0l1kv6n	180	7	like	like	IN
cord-022290-p0l1kv6n	180	8	two	two	CD
cord-022290-p0l1kv6n	180	9	latches	latch	NNS
cord-022290-p0l1kv6n	180	10	(	(	-LRB-
cord-022290-p0l1kv6n	180	11	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	180	12	et	et	NNP
cord-022290-p0l1kv6n	180	13	al	al	NNP
cord-022290-p0l1kv6n	180	14	.	.	NNP
cord-022290-p0l1kv6n	180	15	,	,	,
cord-022290-p0l1kv6n	180	16	1997	1997	CD
cord-022290-p0l1kv6n	180	17	)	)	-RRB-
cord-022290-p0l1kv6n	180	18	.	.	.
cord-022290-p0l1kv6n	181	1	The	the	DT
cord-022290-p0l1kv6n	181	2	N	n	CD
cord-022290-p0l1kv6n	181	3	-	-	HYPH
cord-022290-p0l1kv6n	181	4	terminal	terminal	JJ
cord-022290-p0l1kv6n	181	5	c~-helix	c~-helix	NNP
cord-022290-p0l1kv6n	181	6	is	be	VBZ
cord-022290-p0l1kv6n	181	7	a	a	DT
cord-022290-p0l1kv6n	181	8	unique	unique	JJ
cord-022290-p0l1kv6n	181	9	feature	feature	NN
cord-022290-p0l1kv6n	181	10	of	of	IN
cord-022290-p0l1kv6n	181	11	the	the	DT
cord-022290-p0l1kv6n	181	12	3C	3C	NNP
cord-022290-p0l1kv6n	181	13	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	181	14	among	among	IN
cord-022290-p0l1kv6n	181	15	all	all	DT
cord-022290-p0l1kv6n	181	16	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	181	17	-	-	HYPH
cord-022290-p0l1kv6n	181	18	like	like	JJ
cord-022290-p0l1kv6n	181	19	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	181	20	(	(	-LRB-
cord-022290-p0l1kv6n	181	21	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	181	22	and	and	CC
cord-022290-p0l1kv6n	181	23	Snijder	Snijder	NNP
cord-022290-p0l1kv6n	181	24	,	,	,
cord-022290-p0l1kv6n	181	25	1996	1996	CD
cord-022290-p0l1kv6n	181	26	)	)	-RRB-
cord-022290-p0l1kv6n	181	27	.	.	.
cord-022290-p0l1kv6n	182	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	182	2	has	have	VBZ
cord-022290-p0l1kv6n	182	3	been	be	VBN
cord-022290-p0l1kv6n	182	4	speculated	speculate	VBN
cord-022290-p0l1kv6n	182	5	that	that	IN
cord-022290-p0l1kv6n	182	6	it	-PRON-	PRP
cord-022290-p0l1kv6n	182	7	is	be	VBZ
cord-022290-p0l1kv6n	182	8	important	important	JJ
cord-022290-p0l1kv6n	182	9	for	for	IN
cord-022290-p0l1kv6n	182	10	the	the	DT
cord-022290-p0l1kv6n	182	11	mechanism	mechanism	NN
cord-022290-p0l1kv6n	182	12	of	of	IN
cord-022290-p0l1kv6n	182	13	a	a	DT
cord-022290-p0l1kv6n	182	14	proposed	propose	VBN
cord-022290-p0l1kv6n	182	15	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	182	16	cleavage	cleavage	NN
cord-022290-p0l1kv6n	182	17	at	at	IN
cord-022290-p0l1kv6n	182	18	the	the	DT
cord-022290-p0l1kv6n	182	19	N	n	CD
cord-022290-p0l1kv6n	182	20	-	-	HYPH
cord-022290-p0l1kv6n	182	21	terminus	terminus	NN
cord-022290-p0l1kv6n	182	22	of	of	IN
cord-022290-p0l1kv6n	182	23	3C	3C	NNP
cord-022290-p0l1kv6n	183	1	(	(	-LRB-
cord-022290-p0l1kv6n	183	2	Matthews	Matthews	NNP
cord-022290-p0l1kv6n	183	3	et	et	NNP
cord-022290-p0l1kv6n	183	4	al	al	NNP
cord-022290-p0l1kv6n	183	5	.	.	.
cord-022290-p0l1kv6n	184	1	,	,	,
cord-022290-p0l1kv6n	184	2	1994	1994	CD
cord-022290-p0l1kv6n	184	3	;	;	:
cord-022290-p0l1kv6n	184	4	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	184	5	et	et	NNP
cord-022290-p0l1kv6n	184	6	al	al	NNP
cord-022290-p0l1kv6n	184	7	.	.	NNP
cord-022290-p0l1kv6n	184	8	,	,	,
cord-022290-p0l1kv6n	184	9	1997	1997	CD
cord-022290-p0l1kv6n	184	10	)	)	-RRB-
cord-022290-p0l1kv6n	184	11	.	.	.
cord-022290-p0l1kv6n	185	1	In	in	IN
cord-022290-p0l1kv6n	185	2	the	the	DT
cord-022290-p0l1kv6n	185	3	proposed	propose	VBN
cord-022290-p0l1kv6n	185	4	model	model	NN
cord-022290-p0l1kv6n	185	5	for	for	IN
cord-022290-p0l1kv6n	185	6	the	the	DT
cord-022290-p0l1kv6n	185	7	N	n	CD
cord-022290-p0l1kv6n	185	8	-	-	HYPH
cord-022290-p0l1kv6n	185	9	terminal	terminal	NN
cord-022290-p0l1kv6n	185	10	,	,	,
cord-022290-p0l1kv6n	185	11	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	185	12	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	185	13	cleavage	cleavage	NN
cord-022290-p0l1kv6n	185	14	,	,	,
cord-022290-p0l1kv6n	185	15	this	this	DT
cord-022290-p0l1kv6n	185	16	helix	helix	NN
cord-022290-p0l1kv6n	185	17	is	be	VBZ
cord-022290-p0l1kv6n	185	18	folded	fold	VBN
cord-022290-p0l1kv6n	185	19	after	after	IN
cord-022290-p0l1kv6n	185	20	3C	3C	NNP
cord-022290-p0l1kv6n	185	21	cleaves	cleave	VBZ
cord-022290-p0l1kv6n	185	22	its	-PRON-	PRP$
cord-022290-p0l1kv6n	185	23	own	own	JJ
cord-022290-p0l1kv6n	185	24	N	n	CD
cord-022290-p0l1kv6n	185	25	-	-	HYPH
cord-022290-p0l1kv6n	185	26	terminus	terminus	NN
cord-022290-p0l1kv6n	185	27	.	.	.
cord-022290-p0l1kv6n	186	1	The	the	DT
cord-022290-p0l1kv6n	186	2	favorable	favorable	JJ
cord-022290-p0l1kv6n	186	3	free	free	JJ
cord-022290-p0l1kv6n	186	4	energy	energy	NN
cord-022290-p0l1kv6n	186	5	of	of	IN
cord-022290-p0l1kv6n	186	6	the	the	DT
cord-022290-p0l1kv6n	186	7	folding	folding	NN
cord-022290-p0l1kv6n	186	8	of	of	IN
cord-022290-p0l1kv6n	186	9	this	this	DT
cord-022290-p0l1kv6n	186	10	stable	stable	JJ
cord-022290-p0l1kv6n	186	11	helix	helix	NN
cord-022290-p0l1kv6n	186	12	may	may	MD
cord-022290-p0l1kv6n	186	13	be	be	VB
cord-022290-p0l1kv6n	186	14	required	require	VBN
cord-022290-p0l1kv6n	186	15	to	to	TO
cord-022290-p0l1kv6n	186	16	fold	fold	VB
cord-022290-p0l1kv6n	186	17	the	the	DT
cord-022290-p0l1kv6n	186	18	new	new	JJ
cord-022290-p0l1kv6n	186	19	N	n	CD
cord-022290-p0l1kv6n	186	20	-	-	HYPH
cord-022290-p0l1kv6n	186	21	terminus	terminus	NN
cord-022290-p0l1kv6n	186	22	out	out	IN
cord-022290-p0l1kv6n	186	23	of	of	IN
cord-022290-p0l1kv6n	186	24	the	the	DT
cord-022290-p0l1kv6n	186	25	active	active	JJ
cord-022290-p0l1kv6n	186	26	site	site	NN
cord-022290-p0l1kv6n	186	27	in	in	IN
cord-022290-p0l1kv6n	186	28	order	order	NN
cord-022290-p0l1kv6n	186	29	to	to	TO
cord-022290-p0l1kv6n	186	30	create	create	VB
cord-022290-p0l1kv6n	186	31	the	the	DT
cord-022290-p0l1kv6n	186	32	active	active	JJ
cord-022290-p0l1kv6n	186	33	proteinase	proteinase	NN
cord-022290-p0l1kv6n	186	34	(	(	-LRB-
cord-022290-p0l1kv6n	186	35	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	186	36	et	et	NNP
cord-022290-p0l1kv6n	186	37	al	al	NNP
cord-022290-p0l1kv6n	186	38	.	.	NNP
cord-022290-p0l1kv6n	186	39	,	,	,
cord-022290-p0l1kv6n	186	40	1997	1997	CD
cord-022290-p0l1kv6n	186	41	)	)	-RRB-
cord-022290-p0l1kv6n	186	42	.	.	.
cord-022290-p0l1kv6n	187	1	The	the	DT
cord-022290-p0l1kv6n	187	2	sequence	sequence	NN
cord-022290-p0l1kv6n	187	3	of	of	IN
cord-022290-p0l1kv6n	187	4	the	the	DT
cord-022290-p0l1kv6n	187	5	residues	residue	NNS
cord-022290-p0l1kv6n	187	6	which	which	WDT
cord-022290-p0l1kv6n	187	7	form	form	VBP
cord-022290-p0l1kv6n	187	8	the	the	DT
cord-022290-p0l1kv6n	187	9	last	last	JJ
cord-022290-p0l1kv6n	187	10	turn	turn	NN
cord-022290-p0l1kv6n	187	11	of	of	IN
cord-022290-p0l1kv6n	187	12	this	this	DT
cord-022290-p0l1kv6n	187	13	helix	helix	NN
cord-022290-p0l1kv6n	187	14	is	be	VBZ
cord-022290-p0l1kv6n	187	15	highly	highly	RB
cord-022290-p0l1kv6n	187	16	conserved	conserve	VBN
cord-022290-p0l1kv6n	187	17	throughout	throughout	IN
cord-022290-p0l1kv6n	187	18	the	the	DT
cord-022290-p0l1kv6n	187	19	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	187	20	3C	3C	NNP
cord-022290-p0l1kv6n	187	21	genes	gene	NNS
cord-022290-p0l1kv6n	187	22	(	(	-LRB-
cord-022290-p0l1kv6n	187	23	K	K	NNP
cord-022290-p0l1kv6n	187	24	/	/	SYM
cord-022290-p0l1kv6n	187	25	RR	RR	NNP
cord-022290-p0l1kv6n	187	26	/	/	SYM
cord-022290-p0l1kv6n	187	27	KNL	KNL	NNP
cord-022290-p0l1kv6n	187	28	/	/	SYM
cord-022290-p0l1kv6n	187	29	I	i	NN
cord-022290-p0l1kv6n	187	30	)	)	-RRB-
cord-022290-p0l1kv6n	187	31	,	,	,
cord-022290-p0l1kv6n	187	32	It	-PRON-	PRP
cord-022290-p0l1kv6n	187	33	is	be	VBZ
cord-022290-p0l1kv6n	187	34	interesting	interesting	JJ
cord-022290-p0l1kv6n	187	35	that	that	IN
cord-022290-p0l1kv6n	187	36	the	the	DT
cord-022290-p0l1kv6n	187	37	structural	structural	JJ
cord-022290-p0l1kv6n	187	38	and	and	CC
cord-022290-p0l1kv6n	187	39	functional	functional	JJ
cord-022290-p0l1kv6n	187	40	details	detail	NNS
cord-022290-p0l1kv6n	187	41	of	of	IN
cord-022290-p0l1kv6n	187	42	the	the	DT
cord-022290-p0l1kv6n	187	43	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	187	44	active	active	JJ
cord-022290-p0l1kv6n	187	45	site	site	NN
cord-022290-p0l1kv6n	187	46	of	of	IN
cord-022290-p0l1kv6n	187	47	the	the	DT
cord-022290-p0l1kv6n	187	48	3C	3C	NNP
cord-022290-p0l1kv6n	187	49	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	187	50	are	be	VBP
cord-022290-p0l1kv6n	187	51	not	not	RB
cord-022290-p0l1kv6n	187	52	the	the	DT
cord-022290-p0l1kv6n	187	53	most	most	RBS
cord-022290-p0l1kv6n	187	54	conserved	conserved	JJ
cord-022290-p0l1kv6n	187	55	part	part	NN
cord-022290-p0l1kv6n	187	56	of	of	IN
cord-022290-p0l1kv6n	187	57	the	the	DT
cord-022290-p0l1kv6n	187	58	3C	3C	NNP
cord-022290-p0l1kv6n	187	59	structure	structure	NN
cord-022290-p0l1kv6n	187	60	(	(	-LRB-
cord-022290-p0l1kv6n	187	61	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	187	62	et	et	NNP
cord-022290-p0l1kv6n	187	63	al	al	NNP
cord-022290-p0l1kv6n	187	64	.	.	NNP
cord-022290-p0l1kv6n	187	65	,	,	,
cord-022290-p0l1kv6n	187	66	1988	1988	CD
cord-022290-p0l1kv6n	187	67	)	)	-RRB-
cord-022290-p0l1kv6n	187	68	.	.	.
cord-022290-p0l1kv6n	188	1	The	the	DT
cord-022290-p0l1kv6n	188	2	3C	3c	NN
cord-022290-p0l1kv6n	188	3	gene	gene	NN
cord-022290-p0l1kv6n	188	4	product	product	NN
cord-022290-p0l1kv6n	188	5	constitutes	constitute	VBZ
cord-022290-p0l1kv6n	188	6	one	one	CD
cord-022290-p0l1kv6n	188	7	subunit	subunit	NN
cord-022290-p0l1kv6n	188	8	of	of	IN
cord-022290-p0l1kv6n	188	9	the	the	DT
cord-022290-p0l1kv6n	188	10	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	188	11	RNA	RNA	NNP
cord-022290-p0l1kv6n	188	12	replicase	replicase	NN
cord-022290-p0l1kv6n	188	13	complex	complex	NN
cord-022290-p0l1kv6n	188	14	and	and	CC
cord-022290-p0l1kv6n	188	15	has	have	VBZ
cord-022290-p0l1kv6n	188	16	a	a	DT
cord-022290-p0l1kv6n	188	17	distinct	distinct	JJ
cord-022290-p0l1kv6n	188	18	RNA	RNA	NNP
cord-022290-p0l1kv6n	188	19	binding	binding	NN
cord-022290-p0l1kv6n	188	20	site	site	NN
cord-022290-p0l1kv6n	188	21	(	(	-LRB-
cord-022290-p0l1kv6n	188	22	Hammerle	Hammerle	NNP
cord-022290-p0l1kv6n	188	23	et	et	NNP
cord-022290-p0l1kv6n	188	24	al	al	NNP
cord-022290-p0l1kv6n	188	25	.	.	NNP
cord-022290-p0l1kv6n	188	26	,	,	,
cord-022290-p0l1kv6n	188	27	1992	1992	CD
cord-022290-p0l1kv6n	188	28	;	;	:
cord-022290-p0l1kv6n	188	29	Andino	Andino	NNP
cord-022290-p0l1kv6n	188	30	et	et	NNP
cord-022290-p0l1kv6n	188	31	al	al	NNP
cord-022290-p0l1kv6n	188	32	.	.	NNP
cord-022290-p0l1kv6n	188	33	,	,	,
cord-022290-p0l1kv6n	188	34	1993	1993	CD
cord-022290-p0l1kv6n	188	35	;	;	:
cord-022290-p0l1kv6n	188	36	Leong	Leong	NNP
cord-022290-p0l1kv6n	188	37	et	et	NNP
cord-022290-p0l1kv6n	188	38	al	al	NNP
cord-022290-p0l1kv6n	188	39	.	.	NNP
cord-022290-p0l1kv6n	188	40	,	,	,
cord-022290-p0l1kv6n	188	41	1993	1993	CD
cord-022290-p0l1kv6n	188	42	;	;	:
cord-022290-p0l1kv6n	188	43	Kusov	Kusov	NNP
cord-022290-p0l1kv6n	188	44	et	et	FW
cord-022290-p0l1kv6n	188	45	al	al	NNP
cord-022290-p0l1kv6n	188	46	.	.	NNP
cord-022290-p0l1kv6n	188	47	,	,	,
cord-022290-p0l1kv6n	188	48	1997	1997	CD
cord-022290-p0l1kv6n	188	49	)	)	-RRB-
cord-022290-p0l1kv6n	188	50	.	.	.
cord-022290-p0l1kv6n	189	1	The	the	DT
cord-022290-p0l1kv6n	189	2	sequence	sequence	NN
cord-022290-p0l1kv6n	189	3	of	of	IN
cord-022290-p0l1kv6n	189	4	the	the	DT
cord-022290-p0l1kv6n	189	5	residues	residue	NNS
cord-022290-p0l1kv6n	189	6	which	which	WDT
cord-022290-p0l1kv6n	189	7	have	have	VBP
cord-022290-p0l1kv6n	189	8	been	be	VBN
cord-022290-p0l1kv6n	189	9	implicated	implicate	VBN
cord-022290-p0l1kv6n	189	10	in	in	IN
cord-022290-p0l1kv6n	189	11	this	this	DT
cord-022290-p0l1kv6n	189	12	second	second	JJ
cord-022290-p0l1kv6n	189	13	activity	activity	NN
cord-022290-p0l1kv6n	189	14	,	,	,
cord-022290-p0l1kv6n	189	15	KFRDI	KFRDI	NNP
cord-022290-p0l1kv6n	189	16	,	,	,
cord-022290-p0l1kv6n	189	17	is	be	VBZ
cord-022290-p0l1kv6n	189	18	located	locate	VBN
cord-022290-p0l1kv6n	189	19	in	in	IN
cord-022290-p0l1kv6n	189	20	the	the	DT
cord-022290-p0l1kv6n	189	21	domain	domain	NN
cord-022290-p0l1kv6n	189	22	connection	connection	NN
cord-022290-p0l1kv6n	189	23	of	of	IN
cord-022290-p0l1kv6n	189	24	3C	3C	NNP
cord-022290-p0l1kv6n	189	25	,	,	,
cord-022290-p0l1kv6n	189	26	on	on	IN
cord-022290-p0l1kv6n	189	27	the	the	DT
cord-022290-p0l1kv6n	189	28	opposite	opposite	JJ
cord-022290-p0l1kv6n	189	29	site	site	NN
cord-022290-p0l1kv6n	189	30	of	of	IN
cord-022290-p0l1kv6n	189	31	the	the	DT
cord-022290-p0l1kv6n	189	32	molecule	molecule	NN
cord-022290-p0l1kv6n	189	33	from	from	IN
cord-022290-p0l1kv6n	189	34	the	the	DT
cord-022290-p0l1kv6n	189	35	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	189	36	active	active	JJ
cord-022290-p0l1kv6n	189	37	site	site	NN
cord-022290-p0l1kv6n	189	38	(	(	-LRB-
cord-022290-p0l1kv6n	189	39	Figs	Figs	NNP
cord-022290-p0l1kv6n	189	40	.	.	.
cord-022290-p0l1kv6n	189	41	2b	2b	NNP
cord-022290-p0l1kv6n	189	42	and	and	CC
cord-022290-p0l1kv6n	189	43	3b	3b	CD
cord-022290-p0l1kv6n	189	44	)	)	-RRB-
cord-022290-p0l1kv6n	189	45	.	.	.
cord-022290-p0l1kv6n	190	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	190	2	is	be	VBZ
cord-022290-p0l1kv6n	190	3	completely	completely	RB
cord-022290-p0l1kv6n	190	4	conserved	conserve	VBN
cord-022290-p0l1kv6n	190	5	throughout	throughout	IN
cord-022290-p0l1kv6n	190	6	the	the	DT
cord-022290-p0l1kv6n	190	7	3C	3C	NNP
cord-022290-p0l1kv6n	190	8	gene	gene	NN
cord-022290-p0l1kv6n	190	9	sequences	sequence	NNS
cord-022290-p0l1kv6n	190	10	of	of	IN
cord-022290-p0l1kv6n	190	11	all	all	DT
cord-022290-p0l1kv6n	190	12	picornaviruses	picornavirus	NNS
cord-022290-p0l1kv6n	190	13	.	.	.
cord-022290-p0l1kv6n	191	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	191	2	was	be	VBD
cord-022290-p0l1kv6n	191	3	first	first	RB
cord-022290-p0l1kv6n	191	4	shown	show	VBN
cord-022290-p0l1kv6n	191	5	for	for	IN
cord-022290-p0l1kv6n	191	6	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	191	7	that	that	WDT
cord-022290-p0l1kv6n	191	8	mutations	mutation	NNS
cord-022290-p0l1kv6n	191	9	within	within	IN
cord-022290-p0l1kv6n	191	10	this	this	DT
cord-022290-p0l1kv6n	191	11	sequence	sequence	NN
cord-022290-p0l1kv6n	191	12	are	be	VBP
cord-022290-p0l1kv6n	191	13	deleterious	deleterious	JJ
cord-022290-p0l1kv6n	191	14	for	for	IN
cord-022290-p0l1kv6n	191	15	the	the	DT
cord-022290-p0l1kv6n	191	16	viral	viral	JJ
cord-022290-p0l1kv6n	191	17	replication	replication	NN
cord-022290-p0l1kv6n	191	18	and	and	CC
cord-022290-p0l1kv6n	191	19	show	show	VB
cord-022290-p0l1kv6n	191	20	two	two	CD
cord-022290-p0l1kv6n	191	21	different	different	JJ
cord-022290-p0l1kv6n	191	22	phenotypes	phenotype	NNS
cord-022290-p0l1kv6n	191	23	(	(	-LRB-
cord-022290-p0l1kv6n	191	24	Hammerle	Hammerle	NNP
cord-022290-p0l1kv6n	191	25	et	et	NNP
cord-022290-p0l1kv6n	191	26	al	al	NNP
cord-022290-p0l1kv6n	191	27	.	.	NNP
cord-022290-p0l1kv6n	191	28	,	,	,
cord-022290-p0l1kv6n	191	29	1992	1992	CD
cord-022290-p0l1kv6n	191	30	)	)	-RRB-
cord-022290-p0l1kv6n	191	31	.	.	.
cord-022290-p0l1kv6n	192	1	These	these	DT
cord-022290-p0l1kv6n	192	2	results	result	NNS
cord-022290-p0l1kv6n	192	3	can	can	MD
cord-022290-p0l1kv6n	192	4	now	now	RB
cord-022290-p0l1kv6n	192	5	be	be	VB
cord-022290-p0l1kv6n	192	6	interpreted	interpret	VBN
cord-022290-p0l1kv6n	192	7	in	in	IN
cord-022290-p0l1kv6n	192	8	light	light	NN
cord-022290-p0l1kv6n	192	9	of	of	IN
cord-022290-p0l1kv6n	192	10	the	the	DT
cord-022290-p0l1kv6n	192	11	structures	structure	NNS
cord-022290-p0l1kv6n	192	12	.	.	.
cord-022290-p0l1kv6n	193	1	The	the	DT
cord-022290-p0l1kv6n	193	2	three	three	CD
cord-022290-p0l1kv6n	193	3	charged	charge	VBN
cord-022290-p0l1kv6n	193	4	residues	residue	NNS
cord-022290-p0l1kv6n	193	5	within	within	IN
cord-022290-p0l1kv6n	193	6	the	the	DT
cord-022290-p0l1kv6n	193	7	consensus	consensus	NN
cord-022290-p0l1kv6n	193	8	sequence	sequence	NN
cord-022290-p0l1kv6n	193	9	(	(	-LRB-
cord-022290-p0l1kv6n	193	10	K82	K82	NNP
cord-022290-p0l1kv6n	193	11	,	,	,
cord-022290-p0l1kv6n	193	12	R84	R84	NNP
cord-022290-p0l1kv6n	193	13	,	,	,
cord-022290-p0l1kv6n	193	14	and	and	CC
cord-022290-p0l1kv6n	193	15	D85	D85	NNP
cord-022290-p0l1kv6n	193	16	in	in	IN
cord-022290-p0l1kv6n	193	17	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	193	18	and	and	CC
cord-022290-p0l1kv6n	193	19	K95	K95	NNP
cord-022290-p0l1kv6n	193	20	,	,	,
cord-022290-p0l1kv6n	193	21	R97	R97	NNP
cord-022290-p0l1kv6n	193	22	,	,	,
cord-022290-p0l1kv6n	193	23	and	and	CC
cord-022290-p0l1kv6n	193	24	D98	D98	NNP
cord-022290-p0l1kv6n	193	25	in	in	IN
cord-022290-p0l1kv6n	193	26	HAV	HAV	NNP
cord-022290-p0l1kv6n	193	27	)	)	-RRB-
cord-022290-p0l1kv6n	193	28	form	form	VBP
cord-022290-p0l1kv6n	193	29	part	part	NN
cord-022290-p0l1kv6n	193	30	of	of	IN
cord-022290-p0l1kv6n	193	31	the	the	DT
cord-022290-p0l1kv6n	193	32	surface	surface	NN
cord-022290-p0l1kv6n	193	33	of	of	IN
cord-022290-p0l1kv6n	193	34	the	the	DT
cord-022290-p0l1kv6n	193	35	RNA	RNA	NNP
cord-022290-p0l1kv6n	193	36	binding	binding	NN
cord-022290-p0l1kv6n	193	37	site	site	NN
cord-022290-p0l1kv6n	193	38	and	and	CC
cord-022290-p0l1kv6n	193	39	are	be	VBP
cord-022290-p0l1kv6n	193	40	probably	probably	RB
cord-022290-p0l1kv6n	193	41	directly	directly	RB
cord-022290-p0l1kv6n	193	42	involved	involve	VBN
cord-022290-p0l1kv6n	193	43	in	in	IN
cord-022290-p0l1kv6n	193	44	RNA	RNA	NNP
cord-022290-p0l1kv6n	193	45	binding	binding	NN
cord-022290-p0l1kv6n	193	46	.	.	.
cord-022290-p0l1kv6n	194	1	The	the	DT
cord-022290-p0l1kv6n	194	2	side	side	NN
cord-022290-p0l1kv6n	194	3	-	-	HYPH
cord-022290-p0l1kv6n	194	4	chains	chain	NNS
cord-022290-p0l1kv6n	194	5	of	of	IN
cord-022290-p0l1kv6n	194	6	the	the	DT
cord-022290-p0l1kv6n	194	7	two	two	CD
cord-022290-p0l1kv6n	194	8	highly	highly	RB
cord-022290-p0l1kv6n	194	9	conserved	conserved	JJ
cord-022290-p0l1kv6n	194	10	hydrophobic	hydrophobic	JJ
cord-022290-p0l1kv6n	194	11	residues	residue	NNS
cord-022290-p0l1kv6n	194	12	(	(	-LRB-
cord-022290-p0l1kv6n	194	13	F83	F83	NNP
cord-022290-p0l1kv6n	194	14	and	and	CC
cord-022290-p0l1kv6n	194	15	I86	I86	NNP
cord-022290-p0l1kv6n	194	16	in	in	IN
cord-022290-p0l1kv6n	194	17	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	194	18	3C	3c	NN
cord-022290-p0l1kv6n	194	19	and	and	CC
cord-022290-p0l1kv6n	194	20	F96	F96	NNP
cord-022290-p0l1kv6n	194	21	and	and	CC
cord-022290-p0l1kv6n	194	22	I99	I99	NNP
cord-022290-p0l1kv6n	194	23	in	in	IN
cord-022290-p0l1kv6n	194	24	HAV	HAV	NNP
cord-022290-p0l1kv6n	194	25	)	)	-RRB-
cord-022290-p0l1kv6n	194	26	are	be	VBP
cord-022290-p0l1kv6n	194	27	packed	pack	VBN
cord-022290-p0l1kv6n	194	28	into	into	IN
cord-022290-p0l1kv6n	194	29	the	the	DT
cord-022290-p0l1kv6n	194	30	interior	interior	NN
cord-022290-p0l1kv6n	194	31	of	of	IN
cord-022290-p0l1kv6n	194	32	the	the	DT
cord-022290-p0l1kv6n	194	33	molecule	molecule	NN
cord-022290-p0l1kv6n	194	34	.	.	.
cord-022290-p0l1kv6n	195	1	They	-PRON-	PRP
cord-022290-p0l1kv6n	195	2	are	be	VBP
cord-022290-p0l1kv6n	195	3	part	part	NN
cord-022290-p0l1kv6n	195	4	of	of	IN
cord-022290-p0l1kv6n	195	5	the	the	DT
cord-022290-p0l1kv6n	195	6	internal	internal	JJ
cord-022290-p0l1kv6n	195	7	hydrophobic	hydrophobic	JJ
cord-022290-p0l1kv6n	195	8	interactions	interaction	NNS
cord-022290-p0l1kv6n	195	9	that	that	WDT
cord-022290-p0l1kv6n	195	10	maintain	maintain	VBP
cord-022290-p0l1kv6n	195	11	the	the	DT
cord-022290-p0l1kv6n	195	12	structure	structure	NN
cord-022290-p0l1kv6n	195	13	in	in	IN
cord-022290-p0l1kv6n	195	14	this	this	DT
cord-022290-p0l1kv6n	195	15	region	region	NN
cord-022290-p0l1kv6n	195	16	and	and	CC
cord-022290-p0l1kv6n	195	17	are	be	VBP
cord-022290-p0l1kv6n	195	18	important	important	JJ
cord-022290-p0l1kv6n	195	19	for	for	IN
cord-022290-p0l1kv6n	195	20	this	this	DT
cord-022290-p0l1kv6n	195	21	reason	reason	NN
cord-022290-p0l1kv6n	195	22	.	.	.
cord-022290-p0l1kv6n	196	1	The	the	DT
cord-022290-p0l1kv6n	196	2	side	side	NN
cord-022290-p0l1kv6n	196	3	-	-	HYPH
cord-022290-p0l1kv6n	196	4	chain	chain	NN
cord-022290-p0l1kv6n	196	5	of	of	IN
cord-022290-p0l1kv6n	196	6	the	the	DT
cord-022290-p0l1kv6n	196	7	conserved	conserve	VBN
cord-022290-p0l1kv6n	196	8	phenyalanine	phenyalanine	NN
cord-022290-p0l1kv6n	196	9	interacts	interact	VBZ
cord-022290-p0l1kv6n	196	10	with	with	IN
cord-022290-p0l1kv6n	196	11	a	a	DT
cord-022290-p0l1kv6n	196	12	conserved	conserve	VBN
cord-022290-p0l1kv6n	196	13	glycine	glycine	NN
cord-022290-p0l1kv6n	196	14	at	at	IN
cord-022290-p0l1kv6n	196	15	the	the	DT
cord-022290-p0l1kv6n	196	16	end	end	NN
cord-022290-p0l1kv6n	197	1	of/3-strand	of/3-strand	XX
cord-022290-p0l1kv6n	198	1	bI	bI	NNP
cord-022290-p0l1kv6n	198	2	inside	inside	IN
cord-022290-p0l1kv6n	198	3	the	the	DT
cord-022290-p0l1kv6n	198	4	N	N	NNP
cord-022290-p0l1kv6n	198	5	-	-	HYPH
cord-022290-p0l1kv6n	198	6	terminal/3-barrel	terminal/3-barrel	NN
cord-022290-p0l1kv6n	198	7	.	.	.
cord-022290-p0l1kv6n	199	1	The	the	DT
cord-022290-p0l1kv6n	199	2	sequence	sequence	NN
cord-022290-p0l1kv6n	199	3	surrounding	surround	VBG
cord-022290-p0l1kv6n	199	4	this	this	DT
cord-022290-p0l1kv6n	199	5	glycine	glycine	NN
cord-022290-p0l1kv6n	199	6	,	,	,
cord-022290-p0l1kv6n	199	7	LGVK/,D	LGVK/,D	NNP
cord-022290-p0l1kv6n	199	8	,	,	,
cord-022290-p0l1kv6n	199	9	is	be	VBZ
cord-022290-p0l1kv6n	199	10	also	also	RB
cord-022290-p0l1kv6n	199	11	highly	highly	RB
cord-022290-p0l1kv6n	199	12	conserved	conserve	VBN
cord-022290-p0l1kv6n	199	13	within	within	IN
cord-022290-p0l1kv6n	199	14	the	the	DT
cord-022290-p0l1kv6n	199	15	3C	3C	NNP
cord-022290-p0l1kv6n	199	16	genes	gene	NNS
cord-022290-p0l1kv6n	199	17	.	.	.
cord-022290-p0l1kv6n	200	1	The	the	DT
cord-022290-p0l1kv6n	200	2	residues	residue	NNS
cord-022290-p0l1kv6n	200	3	in	in	IN
cord-022290-p0l1kv6n	200	4	this	this	DT
cord-022290-p0l1kv6n	200	5	sequence	sequence	NN
cord-022290-p0l1kv6n	200	6	motif	motif	NN
cord-022290-p0l1kv6n	200	7	,	,	,
cord-022290-p0l1kv6n	200	8	from	from	IN
cord-022290-p0l1kv6n	200	9	His	-PRON-	PRP$
cord-022290-p0l1kv6n	200	10	31	31	CD
cord-022290-p0l1kv6n	200	11	in	in	IN
cord-022290-p0l1kv6n	200	12	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	200	13	3C	3C	NNP
cord-022290-p0l1kv6n	200	14	and	and	CC
cord-022290-p0l1kv6n	200	15	Lys	Lys	NNP
cord-022290-p0l1kv6n	200	16	35	35	CD
cord-022290-p0l1kv6n	200	17	in	in	IN
cord-022290-p0l1kv6n	200	18	HAV	HAV	NNP
cord-022290-p0l1kv6n	200	19	3C	3C	NNP
cord-022290-p0l1kv6n	200	20	on	on	IN
cord-022290-p0l1kv6n	200	21	,	,	,
cord-022290-p0l1kv6n	200	22	form	form	VB
cord-022290-p0l1kv6n	200	23	a	a	DT
cord-022290-p0l1kv6n	200	24	reverse	reverse	JJ
cord-022290-p0l1kv6n	200	25	turn	turn	NN
cord-022290-p0l1kv6n	200	26	and	and	CC
cord-022290-p0l1kv6n	200	27	connect/3-strand	connect/3-strand	CD
cord-022290-p0l1kv6n	200	28	bI	bi	JJ
cord-022290-p0l1kv6n	200	29	and	and	CC
cord-022290-p0l1kv6n	200	30	cI	cI	NNP
cord-022290-p0l1kv6n	200	31	(	(	-LRB-
cord-022290-p0l1kv6n	200	32	Figs	Figs	NNP
cord-022290-p0l1kv6n	200	33	.	.	.
cord-022290-p0l1kv6n	200	34	2b	2b	NNP
cord-022290-p0l1kv6n	200	35	and	and	CC
cord-022290-p0l1kv6n	200	36	3b	3b	CD
cord-022290-p0l1kv6n	200	37	)	)	-RRB-
cord-022290-p0l1kv6n	200	38	.	.	.
cord-022290-p0l1kv6n	201	1	They	-PRON-	PRP
cord-022290-p0l1kv6n	201	2	contribute	contribute	VBP
cord-022290-p0l1kv6n	201	3	to	to	IN
cord-022290-p0l1kv6n	201	4	the	the	DT
cord-022290-p0l1kv6n	201	5	surface	surface	NN
cord-022290-p0l1kv6n	201	6	of	of	IN
cord-022290-p0l1kv6n	201	7	the	the	DT
cord-022290-p0l1kv6n	201	8	RNA	RNA	NNP
cord-022290-p0l1kv6n	201	9	binding	binding	NN
cord-022290-p0l1kv6n	201	10	site	site	NN
cord-022290-p0l1kv6n	201	11	of	of	IN
cord-022290-p0l1kv6n	201	12	3C.	3C.	NNP
cord-022290-p0l1kv6n	201	13	Presumably	presumably	RB
cord-022290-p0l1kv6n	201	14	,	,	,
cord-022290-p0l1kv6n	201	15	also	also	RB
cord-022290-p0l1kv6n	201	16	contributing	contribute	VBG
cord-022290-p0l1kv6n	201	17	to	to	IN
cord-022290-p0l1kv6n	201	18	the	the	DT
cord-022290-p0l1kv6n	201	19	molecular	molecular	JJ
cord-022290-p0l1kv6n	201	20	surface	surface	NN
cord-022290-p0l1kv6n	201	21	of	of	IN
cord-022290-p0l1kv6n	201	22	the	the	DT
cord-022290-p0l1kv6n	201	23	RNA	RNA	NNP
cord-022290-p0l1kv6n	201	24	binding	binding	NN
cord-022290-p0l1kv6n	201	25	site	site	NN
cord-022290-p0l1kv6n	201	26	are	be	VBP
cord-022290-p0l1kv6n	201	27	the	the	DT
cord-022290-p0l1kv6n	201	28	turns	turn	NNS
cord-022290-p0l1kv6n	201	29	which	which	WDT
cord-022290-p0l1kv6n	201	30	connect/3-strands	connect/3-strands	:
cord-022290-p0l1kv6n	201	31	dI	dI	NNP
cord-022290-p0l1kv6n	201	32	and	and	CC
cord-022290-p0l1kv6n	201	33	eI	eI	NNP
cord-022290-p0l1kv6n	201	34	and	and	CC
cord-022290-p0l1kv6n	201	35	dlI	dlI	NNP
cord-022290-p0l1kv6n	201	36	and	and	CC
cord-022290-p0l1kv6n	201	37	eli	eli	NNP
cord-022290-p0l1kv6n	201	38	(	(	-LRB-
cord-022290-p0l1kv6n	201	39	Figs	Figs	NNP
cord-022290-p0l1kv6n	201	40	.	.	.
cord-022290-p0l1kv6n	201	41	2b	2b	NNP
cord-022290-p0l1kv6n	201	42	and	and	CC
cord-022290-p0l1kv6n	201	43	3b	3b	CD
cord-022290-p0l1kv6n	201	44	)	)	-RRB-
cord-022290-p0l1kv6n	201	45	.	.	.
cord-022290-p0l1kv6n	202	1	The	the	DT
cord-022290-p0l1kv6n	202	2	latter	latter	JJ
cord-022290-p0l1kv6n	202	3	connection	connection	NN
cord-022290-p0l1kv6n	202	4	forms	form	VBZ
cord-022290-p0l1kv6n	202	5	a	a	DT
cord-022290-p0l1kv6n	202	6	single	single	JJ
cord-022290-p0l1kv6n	202	7	turn	turn	NN
cord-022290-p0l1kv6n	202	8	of	of	IN
cord-022290-p0l1kv6n	202	9	a	a	DT
cord-022290-p0l1kv6n	202	10	helix	helix	NN
cord-022290-p0l1kv6n	202	11	in	in	IN
cord-022290-p0l1kv6n	202	12	HAV	HAV	NNP
cord-022290-p0l1kv6n	202	13	3C	3c	CD
cord-022290-p0l1kv6n	202	14	(	(	-LRB-
cord-022290-p0l1kv6n	202	15	Fig	Fig	NNP
cord-022290-p0l1kv6n	202	16	.	.	.
cord-022290-p0l1kv6n	202	17	2b	2b	NNP
cord-022290-p0l1kv6n	202	18	)	)	-RRB-
cord-022290-p0l1kv6n	202	19	.	.	.
cord-022290-p0l1kv6n	203	1	One	one	CD
cord-022290-p0l1kv6n	203	2	face	face	NN
cord-022290-p0l1kv6n	203	3	of	of	IN
cord-022290-p0l1kv6n	203	4	the	the	DT
cord-022290-p0l1kv6n	203	5	N	N	NNP
cord-022290-p0l1kv6n	203	6	-	-	HYPH
cord-022290-p0l1kv6n	203	7	and	and	CC
cord-022290-p0l1kv6n	203	8	C	C	NNP
cord-022290-p0l1kv6n	203	9	-	-	HYPH
cord-022290-p0l1kv6n	203	10	terminal	terminal	NN
cord-022290-p0l1kv6n	203	11	helix	helix	NN
cord-022290-p0l1kv6n	203	12	each	each	DT
cord-022290-p0l1kv6n	203	13	flanks	flank	VBZ
cord-022290-p0l1kv6n	203	14	the	the	DT
cord-022290-p0l1kv6n	203	15	conserved	conserve	VBN
cord-022290-p0l1kv6n	203	16	residues	residue	NNS
cord-022290-p0l1kv6n	203	17	within	within	IN
cord-022290-p0l1kv6n	203	18	the	the	DT
cord-022290-p0l1kv6n	203	19	domain	domain	NN
cord-022290-p0l1kv6n	203	20	connection	connection	NN
cord-022290-p0l1kv6n	203	21	and	and	CC
cord-022290-p0l1kv6n	203	22	probably	probably	RB
cord-022290-p0l1kv6n	203	23	contributes	contribute	VBZ
cord-022290-p0l1kv6n	203	24	to	to	IN
cord-022290-p0l1kv6n	203	25	the	the	DT
cord-022290-p0l1kv6n	203	26	RNA	RNA	NNP
cord-022290-p0l1kv6n	203	27	binding	binding	NN
cord-022290-p0l1kv6n	203	28	site	site	NN
cord-022290-p0l1kv6n	203	29	.	.	.
cord-022290-p0l1kv6n	204	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	204	2	appears	appear	VBZ
cord-022290-p0l1kv6n	204	3	likely	likely	JJ
cord-022290-p0l1kv6n	204	4	,	,	,
cord-022290-p0l1kv6n	204	5	as	as	IN
cord-022290-p0l1kv6n	204	6	was	be	VBD
cord-022290-p0l1kv6n	204	7	proposed	propose	VBN
cord-022290-p0l1kv6n	204	8	by	by	IN
cord-022290-p0l1kv6n	204	9	Ryan	Ryan	NNP
cord-022290-p0l1kv6n	204	10	and	and	CC
cord-022290-p0l1kv6n	204	11	Flint	Flint	NNP
cord-022290-p0l1kv6n	204	12	(	(	-LRB-
cord-022290-p0l1kv6n	204	13	1997	1997	CD
cord-022290-p0l1kv6n	204	14	)	)	-RRB-
cord-022290-p0l1kv6n	204	15	,	,	,
cord-022290-p0l1kv6n	204	16	that	that	IN
cord-022290-p0l1kv6n	204	17	the	the	DT
cord-022290-p0l1kv6n	204	18	binding	binding	NN
cord-022290-p0l1kv6n	204	19	of	of	IN
cord-022290-p0l1kv6n	204	20	RNA	RNA	NNP
cord-022290-p0l1kv6n	204	21	to	to	IN
cord-022290-p0l1kv6n	204	22	this	this	DT
cord-022290-p0l1kv6n	204	23	site	site	NN
cord-022290-p0l1kv6n	204	24	would	would	MD
cord-022290-p0l1kv6n	204	25	have	have	VB
cord-022290-p0l1kv6n	204	26	an	an	DT
cord-022290-p0l1kv6n	204	27	influence	influence	NN
cord-022290-p0l1kv6n	204	28	on	on	IN
cord-022290-p0l1kv6n	204	29	the	the	DT
cord-022290-p0l1kv6n	204	30	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	204	31	processing	processing	NN
cord-022290-p0l1kv6n	204	32	of	of	IN
cord-022290-p0l1kv6n	204	33	both	both	CC
cord-022290-p0l1kv6n	204	34	the	the	DT
cord-022290-p0l1kv6n	204	35	N	N	NNP
cord-022290-p0l1kv6n	204	36	-	-	HYPH
cord-022290-p0l1kv6n	204	37	and	and	CC
cord-022290-p0l1kv6n	204	38	C	C	NNP
cord-022290-p0l1kv6n	204	39	-	-	HYPH
cord-022290-p0l1kv6n	204	40	termini	termini	NNP
cord-022290-p0l1kv6n	204	41	of	of	IN
cord-022290-p0l1kv6n	204	42	3C.	3c.	CD
cord-022290-p0l1kv6n	205	1	On	on	IN
cord-022290-p0l1kv6n	205	2	the	the	DT
cord-022290-p0l1kv6n	205	3	other	other	JJ
cord-022290-p0l1kv6n	205	4	hand	hand	NN
cord-022290-p0l1kv6n	205	5	,	,	,
cord-022290-p0l1kv6n	205	6	it	-PRON-	PRP
cord-022290-p0l1kv6n	205	7	is	be	VBZ
cord-022290-p0l1kv6n	205	8	not	not	RB
cord-022290-p0l1kv6n	205	9	known	know	VBN
cord-022290-p0l1kv6n	205	10	if	if	IN
cord-022290-p0l1kv6n	205	11	binding	bind	VBG
cord-022290-p0l1kv6n	205	12	of	of	IN
cord-022290-p0l1kv6n	205	13	RNA	RNA	NNP
cord-022290-p0l1kv6n	205	14	to	to	IN
cord-022290-p0l1kv6n	205	15	the	the	DT
cord-022290-p0l1kv6n	205	16	RNA	RNA	NNP
cord-022290-p0l1kv6n	205	17	binding	binding	NN
cord-022290-p0l1kv6n	205	18	site	site	NN
cord-022290-p0l1kv6n	205	19	of	of	IN
cord-022290-p0l1kv6n	205	20	3C	3c	NN
cord-022290-p0l1kv6n	205	21	affects	affect	VBZ
cord-022290-p0l1kv6n	205	22	the	the	DT
cord-022290-p0l1kv6n	205	23	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	205	24	activity	activity	NN
cord-022290-p0l1kv6n	205	25	.	.	.
cord-022290-p0l1kv6n	206	1	Only	only	JJ
cord-022290-p0l1kv6n	206	2	structural	structural	JJ
cord-022290-p0l1kv6n	206	3	work	work	NN
cord-022290-p0l1kv6n	206	4	on	on	IN
cord-022290-p0l1kv6n	206	5	a	a	DT
cord-022290-p0l1kv6n	206	6	complex	complex	NN
cord-022290-p0l1kv6n	206	7	of	of	IN
cord-022290-p0l1kv6n	206	8	3C	3c	NN
cord-022290-p0l1kv6n	206	9	and	and	CC
cord-022290-p0l1kv6n	206	10	bound	bind	VBN
cord-022290-p0l1kv6n	206	11	RNA	RNA	NNP
cord-022290-p0l1kv6n	206	12	could	could	MD
cord-022290-p0l1kv6n	206	13	provide	provide	VB
cord-022290-p0l1kv6n	206	14	a	a	DT
cord-022290-p0l1kv6n	206	15	definite	definite	JJ
cord-022290-p0l1kv6n	206	16	answer	answer	NN
cord-022290-p0l1kv6n	206	17	to	to	IN
cord-022290-p0l1kv6n	206	18	this	this	DT
cord-022290-p0l1kv6n	206	19	question	question	NN
cord-022290-p0l1kv6n	206	20	.	.	.
cord-022290-p0l1kv6n	207	1	Because	because	IN
cord-022290-p0l1kv6n	207	2	the	the	DT
cord-022290-p0l1kv6n	207	3	RNA	RNA	NNP
cord-022290-p0l1kv6n	207	4	binding	binding	NN
cord-022290-p0l1kv6n	207	5	site	site	NN
cord-022290-p0l1kv6n	207	6	is	be	VBZ
cord-022290-p0l1kv6n	207	7	on	on	IN
cord-022290-p0l1kv6n	207	8	the	the	DT
cord-022290-p0l1kv6n	207	9	opposite	opposite	JJ
cord-022290-p0l1kv6n	207	10	side	side	NN
cord-022290-p0l1kv6n	207	11	of	of	IN
cord-022290-p0l1kv6n	207	12	the	the	DT
cord-022290-p0l1kv6n	207	13	molecule	molecule	NN
cord-022290-p0l1kv6n	207	14	from	from	IN
cord-022290-p0l1kv6n	207	15	the	the	DT
cord-022290-p0l1kv6n	207	16	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	207	17	active	active	JJ
cord-022290-p0l1kv6n	207	18	site	site	NN
cord-022290-p0l1kv6n	207	19	,	,	,
cord-022290-p0l1kv6n	207	20	the	the	DT
cord-022290-p0l1kv6n	207	21	structures	structure	NNS
cord-022290-p0l1kv6n	207	22	suggest	suggest	VBP
cord-022290-p0l1kv6n	207	23	that	that	IN
cord-022290-p0l1kv6n	207	24	it	-PRON-	PRP
cord-022290-p0l1kv6n	207	25	could	could	MD
cord-022290-p0l1kv6n	207	26	be	be	VB
cord-022290-p0l1kv6n	207	27	possible	possible	JJ
cord-022290-p0l1kv6n	207	28	that	that	IN
cord-022290-p0l1kv6n	207	29	the	the	DT
cord-022290-p0l1kv6n	207	30	two	two	CD
cord-022290-p0l1kv6n	207	31	activities	activity	NNS
cord-022290-p0l1kv6n	207	32	are	be	VBP
cord-022290-p0l1kv6n	207	33	independent	independent	JJ
cord-022290-p0l1kv6n	207	34	.	.	.
cord-022290-p0l1kv6n	208	1	However	however	RB
cord-022290-p0l1kv6n	208	2	,	,	,
cord-022290-p0l1kv6n	208	3	the	the	DT
cord-022290-p0l1kv6n	208	4	3C	3c	NN
cord-022290-p0l1kv6n	208	5	structures	structure	NNS
cord-022290-p0l1kv6n	208	6	also	also	RB
cord-022290-p0l1kv6n	208	7	suggest	suggest	VBP
cord-022290-p0l1kv6n	208	8	a	a	DT
cord-022290-p0l1kv6n	208	9	possible	possible	JJ
cord-022290-p0l1kv6n	208	10	mechanism	mechanism	NN
cord-022290-p0l1kv6n	208	11	whereby	whereby	WRB
cord-022290-p0l1kv6n	208	12	binding	bind	VBG
cord-022290-p0l1kv6n	208	13	of	of	IN
cord-022290-p0l1kv6n	208	14	RNA	RNA	NNP
cord-022290-p0l1kv6n	208	15	in	in	IN
cord-022290-p0l1kv6n	208	16	the	the	DT
cord-022290-p0l1kv6n	208	17	RNA	RNA	NNP
cord-022290-p0l1kv6n	208	18	binding	binding	NN
cord-022290-p0l1kv6n	208	19	site	site	NN
cord-022290-p0l1kv6n	208	20	of	of	IN
cord-022290-p0l1kv6n	208	21	3C	3c	NN
cord-022290-p0l1kv6n	208	22	could	could	MD
cord-022290-p0l1kv6n	208	23	influence	influence	VB
cord-022290-p0l1kv6n	208	24	the	the	DT
cord-022290-p0l1kv6n	208	25	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	208	26	activity	activity	NN
cord-022290-p0l1kv6n	208	27	.	.	.
cord-022290-p0l1kv6n	209	1	The	the	DT
cord-022290-p0l1kv6n	209	2	turns	turn	NNS
cord-022290-p0l1kv6n	209	3	,	,	,
cord-022290-p0l1kv6n	209	4	which	which	WDT
cord-022290-p0l1kv6n	209	5	connect/3-strands	connect/3-strands	:
cord-022290-p0l1kv6n	209	6	bI	bI	NNP
cord-022290-p0l1kv6n	209	7	and	and	CC
cord-022290-p0l1kv6n	209	8	cI	cI	NNP
cord-022290-p0l1kv6n	209	9	and	and	CC
cord-022290-p0l1kv6n	209	10	dII	dII	NNP
cord-022290-p0l1kv6n	209	11	and	and	CC
cord-022290-p0l1kv6n	209	12	eII	eii	RB
cord-022290-p0l1kv6n	209	13	,	,	,
cord-022290-p0l1kv6n	209	14	are	be	VBP
cord-022290-p0l1kv6n	209	15	probably	probably	RB
cord-022290-p0l1kv6n	209	16	involved	involved	JJ
cord-022290-p0l1kv6n	209	17	in	in	IN
cord-022290-p0l1kv6n	209	18	the	the	DT
cord-022290-p0l1kv6n	209	19	specific	specific	JJ
cord-022290-p0l1kv6n	209	20	binding	binding	NN
cord-022290-p0l1kv6n	209	21	of	of	IN
cord-022290-p0l1kv6n	209	22	RNA	RNA	NNP
cord-022290-p0l1kv6n	209	23	.	.	.
cord-022290-p0l1kv6n	210	1	At	at	IN
cord-022290-p0l1kv6n	210	2	the	the	DT
cord-022290-p0l1kv6n	210	3	other	other	JJ
cord-022290-p0l1kv6n	210	4	end	end	NN
cord-022290-p0l1kv6n	210	5	of	of	IN
cord-022290-p0l1kv6n	210	6	each	each	DT
cord-022290-p0l1kv6n	210	7	of	of	IN
cord-022290-p0l1kv6n	210	8	these	these	DT
cord-022290-p0l1kv6n	210	9	strands	strand	NNS
cord-022290-p0l1kv6n	210	10	are	be	VBP
cord-022290-p0l1kv6n	210	11	residues	residue	NNS
cord-022290-p0l1kv6n	210	12	which	which	WDT
cord-022290-p0l1kv6n	210	13	play	play	VBP
cord-022290-p0l1kv6n	210	14	important	important	JJ
cord-022290-p0l1kv6n	210	15	roles	role	NNS
cord-022290-p0l1kv6n	210	16	in	in	IN
cord-022290-p0l1kv6n	210	17	the	the	DT
cord-022290-p0l1kv6n	210	18	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	210	19	activity	activity	NN
cord-022290-p0l1kv6n	210	20	.	.	.
cord-022290-p0l1kv6n	211	1	Slight	slight	JJ
cord-022290-p0l1kv6n	211	2	conformational	conformational	JJ
cord-022290-p0l1kv6n	211	3	changes	change	NNS
cord-022290-p0l1kv6n	211	4	involving	involve	VBG
cord-022290-p0l1kv6n	211	5	these	these	DT
cord-022290-p0l1kv6n	211	6	/	/	SYM
cord-022290-p0l1kv6n	211	7	t	t	NN
cord-022290-p0l1kv6n	211	8	-	-	HYPH
cord-022290-p0l1kv6n	211	9	strands	strand	NNS
cord-022290-p0l1kv6n	211	10	could	could	MD
cord-022290-p0l1kv6n	211	11	have	have	VB
cord-022290-p0l1kv6n	211	12	a	a	DT
cord-022290-p0l1kv6n	211	13	dramatic	dramatic	JJ
cord-022290-p0l1kv6n	211	14	effect	effect	NN
cord-022290-p0l1kv6n	211	15	on	on	IN
cord-022290-p0l1kv6n	211	16	the	the	DT
cord-022290-p0l1kv6n	211	17	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	211	18	activity	activity	NN
cord-022290-p0l1kv6n	211	19	.	.	.
cord-022290-p0l1kv6n	212	1	The	the	DT
cord-022290-p0l1kv6n	212	2	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	212	3	3C	3C	NNP
cord-022290-p0l1kv6n	212	4	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	212	5	are	be	VBP
cord-022290-p0l1kv6n	212	6	relatively	relatively	RB
cord-022290-p0l1kv6n	212	7	slow	slow	JJ
cord-022290-p0l1kv6n	212	8	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	212	9	when	when	WRB
cord-022290-p0l1kv6n	212	10	compared	compare	VBN
cord-022290-p0l1kv6n	212	11	to	to	IN
cord-022290-p0l1kv6n	212	12	some	some	DT
cord-022290-p0l1kv6n	212	13	of	of	IN
cord-022290-p0l1kv6n	212	14	the	the	DT
cord-022290-p0l1kv6n	212	15	mammalian	mammalian	JJ
cord-022290-p0l1kv6n	212	16	,	,	,
cord-022290-p0l1kv6n	212	17	extracellular	extracellular	JJ
cord-022290-p0l1kv6n	212	18	serine	serine	NN
cord-022290-p0l1kv6n	212	19	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	212	20	.	.	.
cord-022290-p0l1kv6n	213	1	They	-PRON-	PRP
cord-022290-p0l1kv6n	213	2	have	have	VBP
cord-022290-p0l1kv6n	213	3	evolved	evolve	VBN
cord-022290-p0l1kv6n	213	4	to	to	TO
cord-022290-p0l1kv6n	213	5	be	be	VB
cord-022290-p0l1kv6n	213	6	very	very	RB
cord-022290-p0l1kv6n	213	7	specific	specific	JJ
cord-022290-p0l1kv6n	213	8	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	213	9	(	(	-LRB-
cord-022290-p0l1kv6n	213	10	Malcolm	Malcolm	NNP
cord-022290-p0l1kv6n	213	11	,	,	,
cord-022290-p0l1kv6n	213	12	1995	1995	CD
cord-022290-p0l1kv6n	213	13	;	;	:
cord-022290-p0l1kv6n	213	14	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	213	15	and	and	CC
cord-022290-p0l1kv6n	213	16	Snijder	Snijder	NNP
cord-022290-p0l1kv6n	213	17	,	,	,
cord-022290-p0l1kv6n	213	18	1996	1996	CD
cord-022290-p0l1kv6n	213	19	;	;	:
cord-022290-p0l1kv6n	213	20	Ryan	Ryan	NNP
cord-022290-p0l1kv6n	213	21	and	and	CC
cord-022290-p0l1kv6n	213	22	Flint	Flint	NNP
cord-022290-p0l1kv6n	213	23	,	,	,
cord-022290-p0l1kv6n	213	24	1997	1997	CD
cord-022290-p0l1kv6n	213	25	;	;	:
cord-022290-p0l1kv6n	213	26	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	213	27	,	,	,
cord-022290-p0l1kv6n	213	28	1998	1998	CD
cord-022290-p0l1kv6n	213	29	and	and	CC
cord-022290-p0l1kv6n	213	30	references	reference	NNS
cord-022290-p0l1kv6n	213	31	therein	therein	RB
cord-022290-p0l1kv6n	213	32	)	)	-RRB-
cord-022290-p0l1kv6n	213	33	.	.	.
cord-022290-p0l1kv6n	214	1	The	the	DT
cord-022290-p0l1kv6n	214	2	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	214	3	-	-	HYPH
cord-022290-p0l1kv6n	214	4	like	like	JJ
cord-022290-p0l1kv6n	214	5	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	214	6	belong	belong	VBP
cord-022290-p0l1kv6n	214	7	to	to	IN
cord-022290-p0l1kv6n	214	8	a	a	DT
cord-022290-p0l1kv6n	214	9	large	large	JJ
cord-022290-p0l1kv6n	214	10	group	group	NN
cord-022290-p0l1kv6n	214	11	of	of	IN
cord-022290-p0l1kv6n	214	12	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	214	13	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	214	14	in	in	IN
cord-022290-p0l1kv6n	214	15	which	which	WDT
cord-022290-p0l1kv6n	214	16	the	the	DT
cord-022290-p0l1kv6n	214	17	nucleophile	nucleophile	NN
cord-022290-p0l1kv6n	214	18	is	be	VBZ
cord-022290-p0l1kv6n	214	19	the	the	DT
cord-022290-p0l1kv6n	214	20	oxygen	oxygen	NN
cord-022290-p0l1kv6n	214	21	or	or	CC
cord-022290-p0l1kv6n	214	22	sulfur	sulfur	NN
cord-022290-p0l1kv6n	214	23	atom	atom	NN
cord-022290-p0l1kv6n	214	24	of	of	IN
cord-022290-p0l1kv6n	214	25	the	the	DT
cord-022290-p0l1kv6n	214	26	side	side	NN
cord-022290-p0l1kv6n	214	27	-	-	HYPH
cord-022290-p0l1kv6n	214	28	chain	chain	NN
cord-022290-p0l1kv6n	214	29	of	of	IN
cord-022290-p0l1kv6n	214	30	a	a	DT
cord-022290-p0l1kv6n	214	31	serine	serine	NN
cord-022290-p0l1kv6n	214	32	or	or	CC
cord-022290-p0l1kv6n	214	33	cysteine	cysteine	NN
cord-022290-p0l1kv6n	214	34	residue	residue	NN
cord-022290-p0l1kv6n	214	35	,	,	,
cord-022290-p0l1kv6n	214	36	respectively	respectively	RB
cord-022290-p0l1kv6n	214	37	.	.	.
cord-022290-p0l1kv6n	215	1	In	in	IN
cord-022290-p0l1kv6n	215	2	these	these	DT
cord-022290-p0l1kv6n	215	3	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	215	4	the	the	DT
cord-022290-p0l1kv6n	215	5	general	general	JJ
cord-022290-p0l1kv6n	215	6	acidbase	acidbase	NN
cord-022290-p0l1kv6n	215	7	catalyst	catalyst	NN
cord-022290-p0l1kv6n	215	8	is	be	VBZ
cord-022290-p0l1kv6n	215	9	a	a	DT
cord-022290-p0l1kv6n	215	10	conserved	conserve	VBN
cord-022290-p0l1kv6n	215	11	histidine	histidine	NN
cord-022290-p0l1kv6n	215	12	residue	residue	NN
cord-022290-p0l1kv6n	215	13	.	.	.
cord-022290-p0l1kv6n	216	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	216	2	is	be	VBZ
cord-022290-p0l1kv6n	216	3	generally	generally	RB
cord-022290-p0l1kv6n	216	4	accepted	accept	VBN
cord-022290-p0l1kv6n	216	5	that	that	IN
cord-022290-p0l1kv6n	216	6	the	the	DT
cord-022290-p0l1kv6n	216	7	mechanism	mechanism	NN
cord-022290-p0l1kv6n	216	8	of	of	IN
cord-022290-p0l1kv6n	216	9	these	these	DT
cord-022290-p0l1kv6n	216	10	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	216	11	involves	involve	VBZ
cord-022290-p0l1kv6n	216	12	an	an	DT
cord-022290-p0l1kv6n	216	13	acyl	acyl	NN
cord-022290-p0l1kv6n	216	14	-	-	HYPH
cord-022290-p0l1kv6n	216	15	enzyme	enzyme	NN
cord-022290-p0l1kv6n	216	16	intermediate	intermediate	NN
cord-022290-p0l1kv6n	216	17	formed	form	VBN
cord-022290-p0l1kv6n	216	18	between	between	IN
cord-022290-p0l1kv6n	216	19	the	the	DT
cord-022290-p0l1kv6n	216	20	nucleophile	nucleophile	NN
cord-022290-p0l1kv6n	216	21	and	and	CC
cord-022290-p0l1kv6n	216	22	the	the	DT
cord-022290-p0l1kv6n	216	23	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	216	24	of	of	IN
cord-022290-p0l1kv6n	216	25	the	the	DT
cord-022290-p0l1kv6n	216	26	P1	P1	NNP
cord-022290-p0l1kv6n	216	27	residue	residue	NN
cord-022290-p0l1kv6n	216	28	of	of	IN
cord-022290-p0l1kv6n	216	29	the	the	DT
cord-022290-p0l1kv6n	216	30	substrate	substrate	NN
cord-022290-p0l1kv6n	216	31	.	.	.
cord-022290-p0l1kv6n	217	1	Additional	additional	JJ
cord-022290-p0l1kv6n	217	2	,	,	,
cord-022290-p0l1kv6n	217	3	so	so	RB
cord-022290-p0l1kv6n	217	4	-	-	HYPH
cord-022290-p0l1kv6n	217	5	called	call	VBN
cord-022290-p0l1kv6n	217	6	tetrahedral	tetrahedral	JJ
cord-022290-p0l1kv6n	217	7	intermediates	intermediate	NNS
cord-022290-p0l1kv6n	217	8	occur	occur	VBP
cord-022290-p0l1kv6n	217	9	both	both	DT
cord-022290-p0l1kv6n	217	10	during	during	IN
cord-022290-p0l1kv6n	217	11	formation	formation	NN
cord-022290-p0l1kv6n	217	12	and	and	CC
cord-022290-p0l1kv6n	217	13	hydrolysis	hydrolysis	NN
cord-022290-p0l1kv6n	217	14	of	of	IN
cord-022290-p0l1kv6n	217	15	the	the	DT
cord-022290-p0l1kv6n	217	16	acyl	acyl	NN
cord-022290-p0l1kv6n	217	17	-	-	HYPH
cord-022290-p0l1kv6n	217	18	enzyme	enzyme	NN
cord-022290-p0l1kv6n	217	19	intermediate	intermediate	NN
cord-022290-p0l1kv6n	217	20	.	.	.
cord-022290-p0l1kv6n	218	1	The	the	DT
cord-022290-p0l1kv6n	218	2	tetrahedral	tetrahedral	JJ
cord-022290-p0l1kv6n	218	3	intermediates	intermediate	NNS
cord-022290-p0l1kv6n	218	4	carry	carry	VBP
cord-022290-p0l1kv6n	218	5	a	a	DT
cord-022290-p0l1kv6n	218	6	negative	negative	JJ
cord-022290-p0l1kv6n	218	7	charge	charge	NN
cord-022290-p0l1kv6n	218	8	on	on	IN
cord-022290-p0l1kv6n	218	9	the	the	DT
cord-022290-p0l1kv6n	218	10	oxygen	oxygen	NN
cord-022290-p0l1kv6n	218	11	atom	atom	NN
cord-022290-p0l1kv6n	218	12	of	of	IN
cord-022290-p0l1kv6n	218	13	the	the	DT
cord-022290-p0l1kv6n	218	14	scissile	scissile	NNP
cord-022290-p0l1kv6n	218	15	peptide	peptide	NNP
cord-022290-p0l1kv6n	218	16	bond	bond	NN
cord-022290-p0l1kv6n	218	17	.	.	.
cord-022290-p0l1kv6n	219	1	In	in	IN
cord-022290-p0l1kv6n	219	2	the	the	DT
cord-022290-p0l1kv6n	219	3	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	219	4	reaction	reaction	NN
cord-022290-p0l1kv6n	219	5	of	of	IN
cord-022290-p0l1kv6n	219	6	the	the	DT
cord-022290-p0l1kv6n	219	7	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	219	8	-	-	HYPH
cord-022290-p0l1kv6n	219	9	like	like	JJ
cord-022290-p0l1kv6n	219	10	serine	serine	NN
cord-022290-p0l1kv6n	219	11	proteinases	proteinase	VBZ
cord-022290-p0l1kv6n	219	12	the	the	DT
cord-022290-p0l1kv6n	219	13	transition	transition	NN
cord-022290-p0l1kv6n	219	14	states	state	NNS
cord-022290-p0l1kv6n	219	15	leading	lead	VBG
cord-022290-p0l1kv6n	219	16	to	to	IN
cord-022290-p0l1kv6n	219	17	the	the	DT
cord-022290-p0l1kv6n	219	18	tetrahedral	tetrahedral	JJ
cord-022290-p0l1kv6n	219	19	intermediates	intermediate	NNS
cord-022290-p0l1kv6n	219	20	are	be	VBP
cord-022290-p0l1kv6n	219	21	rate	rate	NN
cord-022290-p0l1kv6n	219	22	limiting	limiting	NN
cord-022290-p0l1kv6n	219	23	and	and	CC
cord-022290-p0l1kv6n	219	24	structurally	structurally	RB
cord-022290-p0l1kv6n	219	25	resemble	resemble	VB
cord-022290-p0l1kv6n	219	26	the	the	DT
cord-022290-p0l1kv6n	219	27	tetrahedral	tetrahedral	JJ
cord-022290-p0l1kv6n	219	28	intermediates	intermediate	NNS
cord-022290-p0l1kv6n	219	29	.	.	.
cord-022290-p0l1kv6n	220	1	Three	three	CD
cord-022290-p0l1kv6n	220	2	chemical	chemical	NN
cord-022290-p0l1kv6n	220	3	groups	group	NNS
cord-022290-p0l1kv6n	220	4	with	with	IN
cord-022290-p0l1kv6n	220	5	distinct	distinct	JJ
cord-022290-p0l1kv6n	220	6	functions	function	NNS
cord-022290-p0l1kv6n	220	7	are	be	VBP
cord-022290-p0l1kv6n	220	8	typically	typically	RB
cord-022290-p0l1kv6n	220	9	found	find	VBN
cord-022290-p0l1kv6n	220	10	in	in	IN
cord-022290-p0l1kv6n	220	11	the	the	DT
cord-022290-p0l1kv6n	220	12	active	active	JJ
cord-022290-p0l1kv6n	220	13	sites	site	NNS
cord-022290-p0l1kv6n	220	14	of	of	IN
cord-022290-p0l1kv6n	220	15	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	220	16	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	220	17	(	(	-LRB-
cord-022290-p0l1kv6n	220	18	James	James	NNP
cord-022290-p0l1kv6n	220	19	,	,	,
cord-022290-p0l1kv6n	220	20	1993	1993	CD
cord-022290-p0l1kv6n	220	21	;	;	:
cord-022290-p0l1kv6n	220	22	Ryan	Ryan	NNP
cord-022290-p0l1kv6n	220	23	and	and	CC
cord-022290-p0l1kv6n	220	24	Flint	Flint	NNP
cord-022290-p0l1kv6n	220	25	,	,	,
cord-022290-p0l1kv6n	220	26	1997	1997	CD
cord-022290-p0l1kv6n	220	27	)	)	-RRB-
cord-022290-p0l1kv6n	220	28	:	:	:
cord-022290-p0l1kv6n	220	29	a	a	DT
cord-022290-p0l1kv6n	220	30	nucleophile	nucleophile	NN
cord-022290-p0l1kv6n	220	31	,	,	,
cord-022290-p0l1kv6n	220	32	which	which	WDT
cord-022290-p0l1kv6n	220	33	attacks	attack	VBZ
cord-022290-p0l1kv6n	220	34	the	the	DT
cord-022290-p0l1kv6n	220	35	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	220	36	of	of	IN
cord-022290-p0l1kv6n	220	37	the	the	DT
cord-022290-p0l1kv6n	220	38	scissile	scissile	NNP
cord-022290-p0l1kv6n	220	39	peptide	peptide	NNP
cord-022290-p0l1kv6n	220	40	bond	bond	NNP
cord-022290-p0l1kv6n	220	41	;	;	:
cord-022290-p0l1kv6n	220	42	a	a	DT
cord-022290-p0l1kv6n	220	43	general	general	JJ
cord-022290-p0l1kv6n	220	44	acidbase	acidbase	NN
cord-022290-p0l1kv6n	220	45	catalyst	catalyst	NN
cord-022290-p0l1kv6n	220	46	,	,	,
cord-022290-p0l1kv6n	220	47	which	which	WDT
cord-022290-p0l1kv6n	220	48	assists	assist	VBZ
cord-022290-p0l1kv6n	220	49	in	in	IN
cord-022290-p0l1kv6n	220	50	the	the	DT
cord-022290-p0l1kv6n	220	51	attack	attack	NN
cord-022290-p0l1kv6n	220	52	and	and	CC
cord-022290-p0l1kv6n	220	53	protonates	protonate	VBZ
cord-022290-p0l1kv6n	220	54	the	the	DT
cord-022290-p0l1kv6n	220	55	leaving	leave	VBG
cord-022290-p0l1kv6n	220	56	group	group	NN
cord-022290-p0l1kv6n	220	57	;	;	:
cord-022290-p0l1kv6n	220	58	and	and	CC
cord-022290-p0l1kv6n	220	59	an	an	DT
cord-022290-p0l1kv6n	220	60	electrophilic	electrophilic	JJ
cord-022290-p0l1kv6n	220	61	structure	structure	NN
cord-022290-p0l1kv6n	220	62	,	,	,
cord-022290-p0l1kv6n	220	63	which	which	WDT
cord-022290-p0l1kv6n	220	64	stabilizes	stabilize	VBZ
cord-022290-p0l1kv6n	220	65	the	the	DT
cord-022290-p0l1kv6n	220	66	developing	develop	VBG
cord-022290-p0l1kv6n	220	67	negative	negative	JJ
cord-022290-p0l1kv6n	220	68	charge	charge	NN
cord-022290-p0l1kv6n	220	69	on	on	IN
cord-022290-p0l1kv6n	220	70	the	the	DT
cord-022290-p0l1kv6n	220	71	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	220	72	.	.	.
cord-022290-p0l1kv6n	221	1	The	the	DT
cord-022290-p0l1kv6n	221	2	latter	latter	JJ
cord-022290-p0l1kv6n	221	3	structure	structure	NN
cord-022290-p0l1kv6n	221	4	is	be	VBZ
cord-022290-p0l1kv6n	221	5	usually	usually	RB
cord-022290-p0l1kv6n	221	6	referred	refer	VBN
cord-022290-p0l1kv6n	221	7	to	to	IN
cord-022290-p0l1kv6n	221	8	as	as	IN
cord-022290-p0l1kv6n	221	9	the	the	DT
cord-022290-p0l1kv6n	221	10	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	221	11	hole	hole	NN
cord-022290-p0l1kv6n	221	12	.	.	.
cord-022290-p0l1kv6n	222	1	In	in	IN
cord-022290-p0l1kv6n	222	2	the	the	DT
cord-022290-p0l1kv6n	222	3	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	222	4	-	-	HYPH
cord-022290-p0l1kv6n	222	5	like	like	JJ
cord-022290-p0l1kv6n	222	6	serine	serine	NN
cord-022290-p0l1kv6n	222	7	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	222	8	it	-PRON-	PRP
cord-022290-p0l1kv6n	222	9	consists	consist	VBZ
cord-022290-p0l1kv6n	222	10	of	of	IN
cord-022290-p0l1kv6n	222	11	a	a	DT
cord-022290-p0l1kv6n	222	12	stretch	stretch	NN
cord-022290-p0l1kv6n	222	13	of	of	IN
cord-022290-p0l1kv6n	222	14	seven	seven	CD
cord-022290-p0l1kv6n	222	15	residues	residue	NNS
cord-022290-p0l1kv6n	222	16	with	with	IN
cord-022290-p0l1kv6n	222	17	a	a	DT
cord-022290-p0l1kv6n	222	18	consensus	consensus	NN
cord-022290-p0l1kv6n	222	19	sequence	sequence	NN
cord-022290-p0l1kv6n	222	20	XGDSGG	XGDSGG	NNP
cord-022290-p0l1kv6n	222	21	,	,	,
cord-022290-p0l1kv6n	222	22	where	where	WRB
cord-022290-p0l1kv6n	222	23	the	the	DT
cord-022290-p0l1kv6n	222	24	serine	serine	NN
cord-022290-p0l1kv6n	222	25	is	be	VBZ
cord-022290-p0l1kv6n	222	26	the	the	DT
cord-022290-p0l1kv6n	222	27	nucleophile	nucleophile	NN
cord-022290-p0l1kv6n	222	28	.	.	.
cord-022290-p0l1kv6n	223	1	The	the	DT
cord-022290-p0l1kv6n	223	2	main	main	JJ
cord-022290-p0l1kv6n	223	3	-	-	HYPH
cord-022290-p0l1kv6n	223	4	chain	chain	NN
cord-022290-p0l1kv6n	223	5	conformation	conformation	NN
cord-022290-p0l1kv6n	223	6	of	of	IN
cord-022290-p0l1kv6n	223	7	this	this	DT
cord-022290-p0l1kv6n	223	8	structure	structure	NN
cord-022290-p0l1kv6n	223	9	orients	orient	VBZ
cord-022290-p0l1kv6n	223	10	the	the	DT
cord-022290-p0l1kv6n	223	11	first	first	JJ
cord-022290-p0l1kv6n	223	12	and	and	CC
cord-022290-p0l1kv6n	223	13	third	third	JJ
cord-022290-p0l1kv6n	223	14	peptide	peptide	NN
cord-022290-p0l1kv6n	223	15	bonds	bond	NNS
cord-022290-p0l1kv6n	223	16	so	so	IN
cord-022290-p0l1kv6n	223	17	that	that	IN
cord-022290-p0l1kv6n	223	18	they	-PRON-	PRP
cord-022290-p0l1kv6n	223	19	donate	donate	VBP
cord-022290-p0l1kv6n	223	20	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	223	21	bonds	bond	NNS
cord-022290-p0l1kv6n	223	22	to	to	IN
cord-022290-p0l1kv6n	223	23	the	the	DT
cord-022290-p0l1kv6n	223	24	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	223	25	of	of	IN
cord-022290-p0l1kv6n	223	26	the	the	DT
cord-022290-p0l1kv6n	223	27	scissile	scissile	NNP
cord-022290-p0l1kv6n	223	28	bond	bond	NNP
cord-022290-p0l1kv6n	223	29	.	.	.
cord-022290-p0l1kv6n	224	1	These	these	DT
cord-022290-p0l1kv6n	224	2	two	two	CD
cord-022290-p0l1kv6n	224	3	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	224	4	bonds	bond	NNS
cord-022290-p0l1kv6n	224	5	of	of	IN
cord-022290-p0l1kv6n	224	6	the	the	DT
cord-022290-p0l1kv6n	224	7	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	224	8	hole	hole	NN
cord-022290-p0l1kv6n	224	9	help	help	NN
cord-022290-p0l1kv6n	224	10	to	to	TO
cord-022290-p0l1kv6n	224	11	stabilize	stabilize	VB
cord-022290-p0l1kv6n	224	12	the	the	DT
cord-022290-p0l1kv6n	224	13	developing	develop	VBG
cord-022290-p0l1kv6n	224	14	negative	negative	JJ
cord-022290-p0l1kv6n	224	15	charge	charge	NN
cord-022290-p0l1kv6n	224	16	on	on	IN
cord-022290-p0l1kv6n	224	17	the	the	DT
cord-022290-p0l1kv6n	224	18	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	224	19	oxygen	oxygen	NN
cord-022290-p0l1kv6n	224	20	during	during	IN
cord-022290-p0l1kv6n	224	21	the	the	DT
cord-022290-p0l1kv6n	224	22	reaction	reaction	NN
cord-022290-p0l1kv6n	224	23	(	(	-LRB-
cord-022290-p0l1kv6n	224	24	Whiting	Whiting	NNP
cord-022290-p0l1kv6n	224	25	and	and	CC
cord-022290-p0l1kv6n	224	26	Peticolas	Peticolas	NNP
cord-022290-p0l1kv6n	224	27	,	,	,
cord-022290-p0l1kv6n	224	28	1994	1994	CD
cord-022290-p0l1kv6n	224	29	)	)	-RRB-
cord-022290-p0l1kv6n	224	30	.	.	.
cord-022290-p0l1kv6n	225	1	There	there	EX
cord-022290-p0l1kv6n	225	2	are	be	VBP
cord-022290-p0l1kv6n	225	3	additional	additional	JJ
cord-022290-p0l1kv6n	225	4	chemical	chemical	JJ
cord-022290-p0l1kv6n	225	5	groups	group	NNS
cord-022290-p0l1kv6n	225	6	in	in	IN
cord-022290-p0l1kv6n	225	7	the	the	DT
cord-022290-p0l1kv6n	225	8	active	active	JJ
cord-022290-p0l1kv6n	225	9	site	site	NN
cord-022290-p0l1kv6n	225	10	of	of	IN
cord-022290-p0l1kv6n	225	11	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	225	12	,	,	,
cord-022290-p0l1kv6n	225	13	the	the	DT
cord-022290-p0l1kv6n	225	14	function	function	NN
cord-022290-p0l1kv6n	225	15	of	of	IN
cord-022290-p0l1kv6n	225	16	which	which	WDT
cord-022290-p0l1kv6n	225	17	is	be	VBZ
cord-022290-p0l1kv6n	225	18	less	less	RBR
cord-022290-p0l1kv6n	225	19	clear	clear	JJ
cord-022290-p0l1kv6n	225	20	.	.	.
cord-022290-p0l1kv6n	226	1	In	in	IN
cord-022290-p0l1kv6n	226	2	the	the	DT
cord-022290-p0l1kv6n	226	3	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	226	4	-	-	HYPH
cord-022290-p0l1kv6n	226	5	like	like	JJ
cord-022290-p0l1kv6n	226	6	serine	serine	NN
cord-022290-p0l1kv6n	226	7	proteinases	proteinase	VBZ
cord-022290-p0l1kv6n	226	8	the	the	DT
cord-022290-p0l1kv6n	226	9	carboxylate	carboxylate	NNP
cord-022290-p0l1kv6n	226	10	of	of	IN
cord-022290-p0l1kv6n	226	11	an	an	DT
cord-022290-p0l1kv6n	226	12	aspartate	aspartate	JJ
cord-022290-p0l1kv6n	226	13	residue	residue	NN
cord-022290-p0l1kv6n	226	14	interacts	interact	VBZ
cord-022290-p0l1kv6n	226	15	with	with	IN
cord-022290-p0l1kv6n	226	16	the	the	DT
cord-022290-p0l1kv6n	226	17	edge	edge	NN
cord-022290-p0l1kv6n	226	18	of	of	IN
cord-022290-p0l1kv6n	226	19	the	the	DT
cord-022290-p0l1kv6n	226	20	imidazole	imidazole	NN
cord-022290-p0l1kv6n	226	21	of	of	IN
cord-022290-p0l1kv6n	226	22	the	the	DT
cord-022290-p0l1kv6n	226	23	histidine	histidine	NN
cord-022290-p0l1kv6n	226	24	general	general	JJ
cord-022290-p0l1kv6n	226	25	acid	acid	NN
cord-022290-p0l1kv6n	226	26	-	-	HYPH
cord-022290-p0l1kv6n	226	27	base	base	NN
cord-022290-p0l1kv6n	226	28	catalyst	catalyst	NN
cord-022290-p0l1kv6n	226	29	,	,	,
cord-022290-p0l1kv6n	226	30	which	which	WDT
cord-022290-p0l1kv6n	226	31	is	be	VBZ
cord-022290-p0l1kv6n	226	32	opposite	opposite	JJ
cord-022290-p0l1kv6n	226	33	from	from	IN
cord-022290-p0l1kv6n	226	34	the	the	DT
cord-022290-p0l1kv6n	226	35	nucleophile	nucleophile	NN
cord-022290-p0l1kv6n	226	36	(	(	-LRB-
cord-022290-p0l1kv6n	226	37	N	N	NNP
cord-022290-p0l1kv6n	226	38	s	s	NNP
cord-022290-p0l1kv6n	226	39	)	)	-RRB-
cord-022290-p0l1kv6n	226	40	.	.	.
cord-022290-p0l1kv6n	227	1	Originally	originally	RB
cord-022290-p0l1kv6n	227	2	it	-PRON-	PRP
cord-022290-p0l1kv6n	227	3	was	be	VBD
cord-022290-p0l1kv6n	227	4	thought	think	VBN
cord-022290-p0l1kv6n	227	5	that	that	IN
cord-022290-p0l1kv6n	227	6	this	this	DT
cord-022290-p0l1kv6n	227	7	"	"	``
cord-022290-p0l1kv6n	227	8	third	third	JJ
cord-022290-p0l1kv6n	227	9	member	member	NN
cord-022290-p0l1kv6n	227	10	of	of	IN
cord-022290-p0l1kv6n	227	11	the	the	DT
cord-022290-p0l1kv6n	227	12	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	227	13	triad	triad	NN
cord-022290-p0l1kv6n	227	14	"	"	''
cord-022290-p0l1kv6n	227	15	participates	participate	VBZ
cord-022290-p0l1kv6n	227	16	in	in	IN
cord-022290-p0l1kv6n	227	17	a	a	DT
cord-022290-p0l1kv6n	227	18	proton	proton	NN
cord-022290-p0l1kv6n	227	19	transfer	transfer	NN
cord-022290-p0l1kv6n	227	20	,	,	,
cord-022290-p0l1kv6n	227	21	but	but	CC
cord-022290-p0l1kv6n	227	22	it	-PRON-	PRP
cord-022290-p0l1kv6n	227	23	is	be	VBZ
cord-022290-p0l1kv6n	227	24	now	now	RB
cord-022290-p0l1kv6n	227	25	generally	generally	RB
cord-022290-p0l1kv6n	227	26	believed	believe	VBN
cord-022290-p0l1kv6n	227	27	that	that	IN
cord-022290-p0l1kv6n	227	28	its	-PRON-	PRP$
cord-022290-p0l1kv6n	227	29	function	function	NN
cord-022290-p0l1kv6n	227	30	is	be	VBZ
cord-022290-p0l1kv6n	227	31	to	to	TO
cord-022290-p0l1kv6n	227	32	maintain	maintain	VB
cord-022290-p0l1kv6n	227	33	the	the	DT
cord-022290-p0l1kv6n	227	34	orientation	orientation	NN
cord-022290-p0l1kv6n	227	35	of	of	IN
cord-022290-p0l1kv6n	227	36	the	the	DT
cord-022290-p0l1kv6n	227	37	histidine	histidine	NN
cord-022290-p0l1kv6n	227	38	general	general	JJ
cord-022290-p0l1kv6n	227	39	acid	acid	NN
cord-022290-p0l1kv6n	227	40	-	-	HYPH
cord-022290-p0l1kv6n	227	41	base	base	NN
cord-022290-p0l1kv6n	227	42	catalyst	catalyst	NN
cord-022290-p0l1kv6n	227	43	and	and	CC
cord-022290-p0l1kv6n	227	44	possibly	possibly	RB
cord-022290-p0l1kv6n	227	45	to	to	TO
cord-022290-p0l1kv6n	227	46	stabilize	stabilize	VB
cord-022290-p0l1kv6n	227	47	its	-PRON-	PRP$
cord-022290-p0l1kv6n	227	48	developing	develop	VBG
cord-022290-p0l1kv6n	227	49	positive	positive	JJ
cord-022290-p0l1kv6n	227	50	charge	charge	NN
cord-022290-p0l1kv6n	227	51	.	.	.
cord-022290-p0l1kv6n	228	1	There	there	EX
cord-022290-p0l1kv6n	228	2	are	be	VBP
cord-022290-p0l1kv6n	228	3	chemical	chemical	JJ
cord-022290-p0l1kv6n	228	4	groups	group	NNS
cord-022290-p0l1kv6n	228	5	in	in	IN
cord-022290-p0l1kv6n	228	6	similar	similar	JJ
cord-022290-p0l1kv6n	228	7	positions	position	NNS
cord-022290-p0l1kv6n	228	8	to	to	IN
cord-022290-p0l1kv6n	228	9	the	the	DT
cord-022290-p0l1kv6n	228	10	carboxylate	carboxylate	NNP
cord-022290-p0l1kv6n	228	11	of	of	IN
cord-022290-p0l1kv6n	228	12	the	the	DT
cord-022290-p0l1kv6n	228	13	third	third	JJ
cord-022290-p0l1kv6n	228	14	member	member	NN
cord-022290-p0l1kv6n	228	15	of	of	IN
cord-022290-p0l1kv6n	228	16	the	the	DT
cord-022290-p0l1kv6n	228	17	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	228	18	triad	triad	NN
cord-022290-p0l1kv6n	228	19	in	in	IN
cord-022290-p0l1kv6n	228	20	the	the	DT
cord-022290-p0l1kv6n	228	21	3C	3C	NNP
cord-022290-p0l1kv6n	228	22	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	228	23	,	,	,
cord-022290-p0l1kv6n	228	24	but	but	CC
cord-022290-p0l1kv6n	228	25	the	the	DT
cord-022290-p0l1kv6n	228	26	interactions	interaction	NNS
cord-022290-p0l1kv6n	228	27	with	with	IN
cord-022290-p0l1kv6n	228	28	the	the	DT
cord-022290-p0l1kv6n	228	29	histidine	histidine	NN
cord-022290-p0l1kv6n	228	30	general	general	JJ
cord-022290-p0l1kv6n	228	31	acid	acid	NN
cord-022290-p0l1kv6n	228	32	-	-	HYPH
cord-022290-p0l1kv6n	228	33	base	base	NN
cord-022290-p0l1kv6n	228	34	catalyst	catalyst	NN
cord-022290-p0l1kv6n	228	35	are	be	VBP
cord-022290-p0l1kv6n	228	36	different	different	JJ
cord-022290-p0l1kv6n	228	37	(	(	-LRB-
cord-022290-p0l1kv6n	228	38	Fig	Fig	NNP
cord-022290-p0l1kv6n	228	39	.	.	NNP
cord-022290-p0l1kv6n	228	40	4	4	CD
cord-022290-p0l1kv6n	228	41	,	,	,
cord-022290-p0l1kv6n	228	42	see	see	VB
cord-022290-p0l1kv6n	228	43	color	color	NN
cord-022290-p0l1kv6n	228	44	plate	plate	NN
cord-022290-p0l1kv6n	228	45	)	)	-RRB-
cord-022290-p0l1kv6n	228	46	.	.	.
cord-022290-p0l1kv6n	229	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	229	2	is	be	VBZ
cord-022290-p0l1kv6n	229	3	generally	generally	RB
cord-022290-p0l1kv6n	229	4	accepted	accept	VBN
cord-022290-p0l1kv6n	229	5	that	that	IN
cord-022290-p0l1kv6n	229	6	the	the	DT
cord-022290-p0l1kv6n	229	7	active	active	JJ
cord-022290-p0l1kv6n	229	8	sites	site	NNS
cord-022290-p0l1kv6n	229	9	of	of	IN
cord-022290-p0l1kv6n	229	10	cysteine	cysteine	NN
cord-022290-p0l1kv6n	229	11	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	229	12	,	,	,
cord-022290-p0l1kv6n	229	13	such	such	JJ
cord-022290-p0l1kv6n	229	14	as	as	IN
cord-022290-p0l1kv6n	229	15	the	the	DT
cord-022290-p0l1kv6n	229	16	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	229	17	of	of	IN
cord-022290-p0l1kv6n	229	18	the	the	DT
cord-022290-p0l1kv6n	229	19	papain	papain	NN
cord-022290-p0l1kv6n	229	20	family	family	NN
cord-022290-p0l1kv6n	229	21	,	,	,
cord-022290-p0l1kv6n	229	22	contain	contain	VBP
cord-022290-p0l1kv6n	229	23	a	a	DT
cord-022290-p0l1kv6n	229	24	thiolate	thiolate	JJ
cord-022290-p0l1kv6n	229	25	-	-	HYPH
cord-022290-p0l1kv6n	229	26	imidazolium	imidazolium	NN
cord-022290-p0l1kv6n	229	27	ion	ion	NN
cord-022290-p0l1kv6n	229	28	pair	pair	NN
cord-022290-p0l1kv6n	229	29	that	that	WDT
cord-022290-p0l1kv6n	229	30	is	be	VBZ
cord-022290-p0l1kv6n	229	31	stabilized	stabilize	VBN
cord-022290-p0l1kv6n	229	32	over	over	IN
cord-022290-p0l1kv6n	229	33	a	a	DT
cord-022290-p0l1kv6n	229	34	wide	wide	JJ
cord-022290-p0l1kv6n	229	35	pH	ph	NN
cord-022290-p0l1kv6n	229	36	range	range	NN
cord-022290-p0l1kv6n	229	37	(	(	-LRB-
cord-022290-p0l1kv6n	229	38	Storer	Storer	NNP
cord-022290-p0l1kv6n	229	39	and	and	CC
cord-022290-p0l1kv6n	229	40	M	M	NNP
cord-022290-p0l1kv6n	229	41	~	~	NNP
cord-022290-p0l1kv6n	229	42	nard	nard	NN
cord-022290-p0l1kv6n	229	43	,	,	,
cord-022290-p0l1kv6n	229	44	1994	1994	CD
cord-022290-p0l1kv6n	229	45	)	)	-RRB-
cord-022290-p0l1kv6n	229	46	.	.	.
cord-022290-p0l1kv6n	230	1	The	the	DT
cord-022290-p0l1kv6n	230	2	active	active	JJ
cord-022290-p0l1kv6n	230	3	site	site	NN
cord-022290-p0l1kv6n	230	4	of	of	IN
cord-022290-p0l1kv6n	230	5	the	the	DT
cord-022290-p0l1kv6n	230	6	3C	3C	NNP
cord-022290-p0l1kv6n	230	7	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	230	8	feature	feature	VBP
cord-022290-p0l1kv6n	230	9	a	a	DT
cord-022290-p0l1kv6n	230	10	thiol	thiol	NN
cord-022290-p0l1kv6n	230	11	and	and	CC
cord-022290-p0l1kv6n	230	12	an	an	DT
cord-022290-p0l1kv6n	230	13	imidazole	imidazole	NN
cord-022290-p0l1kv6n	231	1	but	but	CC
cord-022290-p0l1kv6n	231	2	in	in	IN
cord-022290-p0l1kv6n	231	3	the	the	DT
cord-022290-p0l1kv6n	231	4	structural	structural	JJ
cord-022290-p0l1kv6n	231	5	context	context	NN
cord-022290-p0l1kv6n	231	6	of	of	IN
cord-022290-p0l1kv6n	231	7	a	a	DT
cord-022290-p0l1kv6n	231	8	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	231	9	-	-	HYPH
cord-022290-p0l1kv6n	231	10	like	like	JJ
cord-022290-p0l1kv6n	231	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	231	12	.	.	.
cord-022290-p0l1kv6n	232	1	There	there	EX
cord-022290-p0l1kv6n	232	2	is	be	VBZ
cord-022290-p0l1kv6n	232	3	no	no	DT
cord-022290-p0l1kv6n	232	4	direct	direct	JJ
cord-022290-p0l1kv6n	232	5	experimental	experimental	JJ
cord-022290-p0l1kv6n	232	6	evidence	evidence	NN
cord-022290-p0l1kv6n	232	7	for	for	IN
cord-022290-p0l1kv6n	232	8	the	the	DT
cord-022290-p0l1kv6n	232	9	charge	charge	NN
cord-022290-p0l1kv6n	232	10	and	and	CC
cord-022290-p0l1kv6n	232	11	protonation	protonation	NN
cord-022290-p0l1kv6n	232	12	state	state	NN
cord-022290-p0l1kv6n	232	13	in	in	IN
cord-022290-p0l1kv6n	232	14	the	the	DT
cord-022290-p0l1kv6n	232	15	active	active	JJ
cord-022290-p0l1kv6n	232	16	site	site	NN
cord-022290-p0l1kv6n	232	17	of	of	IN
cord-022290-p0l1kv6n	232	18	the	the	DT
cord-022290-p0l1kv6n	232	19	3C	3C	NNP
cord-022290-p0l1kv6n	232	20	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	232	21	.	.	.
cord-022290-p0l1kv6n	233	1	Even	even	RB
cord-022290-p0l1kv6n	233	2	though	though	IN
cord-022290-p0l1kv6n	233	3	the	the	DT
cord-022290-p0l1kv6n	233	4	3C	3C	NNP
cord-022290-p0l1kv6n	233	5	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	233	6	belong	belong	VBP
cord-022290-p0l1kv6n	233	7	to	to	IN
cord-022290-p0l1kv6n	233	8	the	the	DT
cord-022290-p0l1kv6n	233	9	superfamily	superfamily	NN
cord-022290-p0l1kv6n	233	10	of	of	IN
cord-022290-p0l1kv6n	233	11	the	the	DT
cord-022290-p0l1kv6n	233	12	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	233	13	-	-	HYPH
cord-022290-p0l1kv6n	233	14	like	like	JJ
cord-022290-p0l1kv6n	233	15	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	233	16	,	,	,
cord-022290-p0l1kv6n	233	17	they	-PRON-	PRP
cord-022290-p0l1kv6n	233	18	are	be	VBP
cord-022290-p0l1kv6n	233	19	cysteine	cysteine	NN
cord-022290-p0l1kv6n	233	20	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	233	21	.	.	.
cord-022290-p0l1kv6n	234	1	Whether	whether	IN
cord-022290-p0l1kv6n	234	2	the	the	DT
cord-022290-p0l1kv6n	234	3	mechanism	mechanism	NN
cord-022290-p0l1kv6n	234	4	of	of	IN
cord-022290-p0l1kv6n	234	5	3C	3C	NNP
cord-022290-p0l1kv6n	234	6	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	234	7	more	more	RBR
cord-022290-p0l1kv6n	234	8	closely	closely	RB
cord-022290-p0l1kv6n	234	9	resembles	resemble	VBZ
cord-022290-p0l1kv6n	234	10	the	the	DT
cord-022290-p0l1kv6n	234	11	mechanism	mechanism	NN
cord-022290-p0l1kv6n	234	12	of	of	IN
cord-022290-p0l1kv6n	234	13	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	234	14	-	-	HYPH
cord-022290-p0l1kv6n	234	15	like	like	JJ
cord-022290-p0l1kv6n	234	16	serine	serine	NN
cord-022290-p0l1kv6n	234	17	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	234	18	or	or	CC
cord-022290-p0l1kv6n	234	19	other	other	JJ
cord-022290-p0l1kv6n	234	20	cysteine	cysteine	NN
cord-022290-p0l1kv6n	234	21	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	234	22	or	or	CC
cord-022290-p0l1kv6n	234	23	is	be	VBZ
cord-022290-p0l1kv6n	234	24	unique	unique	JJ
cord-022290-p0l1kv6n	234	25	is	be	VBZ
cord-022290-p0l1kv6n	234	26	not	not	RB
cord-022290-p0l1kv6n	234	27	clear	clear	JJ
cord-022290-p0l1kv6n	234	28	.	.	.
cord-022290-p0l1kv6n	235	1	Figure	figure	NN
cord-022290-p0l1kv6n	235	2	4	4	CD
cord-022290-p0l1kv6n	235	3	shows	show	VBZ
cord-022290-p0l1kv6n	235	4	the	the	DT
cord-022290-p0l1kv6n	235	5	details	detail	NNS
cord-022290-p0l1kv6n	235	6	of	of	IN
cord-022290-p0l1kv6n	235	7	the	the	DT
cord-022290-p0l1kv6n	235	8	active	active	JJ
cord-022290-p0l1kv6n	235	9	site	site	NN
cord-022290-p0l1kv6n	235	10	residues	residue	NNS
cord-022290-p0l1kv6n	235	11	of	of	IN
cord-022290-p0l1kv6n	235	12	the	the	DT
cord-022290-p0l1kv6n	235	13	3C	3C	NNP
cord-022290-p0l1kv6n	235	14	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	235	15	from	from	IN
cord-022290-p0l1kv6n	235	16	HAV	HAV	NNP
cord-022290-p0l1kv6n	235	17	(	(	-LRB-
cord-022290-p0l1kv6n	235	18	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	235	19	et	et	NNP
cord-022290-p0l1kv6n	235	20	al	al	NNP
cord-022290-p0l1kv6n	235	21	.	.	NNP
cord-022290-p0l1kv6n	235	22	,	,	,
cord-022290-p0l1kv6n	235	23	1997	1997	CD
cord-022290-p0l1kv6n	235	24	)	)	-RRB-
cord-022290-p0l1kv6n	235	25	and	and	CC
cord-022290-p0l1kv6n	235	26	PV	PV	NNP
cord-022290-p0l1kv6n	235	27	.	.	.
cord-022290-p0l1kv6n	236	1	The	the	DT
cord-022290-p0l1kv6n	236	2	arrangement	arrangement	NN
cord-022290-p0l1kv6n	236	3	of	of	IN
cord-022290-p0l1kv6n	236	4	the	the	DT
cord-022290-p0l1kv6n	236	5	cysteine	cysteine	NN
cord-022290-p0l1kv6n	236	6	-	-	HYPH
cord-022290-p0l1kv6n	236	7	histidine	histidine	NN
cord-022290-p0l1kv6n	236	8	dyad	dyad	NN
cord-022290-p0l1kv6n	236	9	and	and	CC
cord-022290-p0l1kv6n	236	10	the	the	DT
cord-022290-p0l1kv6n	236	11	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	236	12	hole	hole	NN
cord-022290-p0l1kv6n	236	13	is	be	VBZ
cord-022290-p0l1kv6n	236	14	similar	similar	JJ
cord-022290-p0l1kv6n	236	15	to	to	IN
cord-022290-p0l1kv6n	236	16	that	that	DT
cord-022290-p0l1kv6n	236	17	observed	observe	VBN
cord-022290-p0l1kv6n	236	18	in	in	IN
cord-022290-p0l1kv6n	236	19	the	the	DT
cord-022290-p0l1kv6n	236	20	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	236	21	-	-	HYPH
cord-022290-p0l1kv6n	236	22	like	like	JJ
cord-022290-p0l1kv6n	236	23	serine	serine	NN
cord-022290-p0l1kv6n	236	24	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	236	25	but	but	CC
cord-022290-p0l1kv6n	236	26	due	due	IN
cord-022290-p0l1kv6n	236	27	to	to	IN
cord-022290-p0l1kv6n	236	28	the	the	DT
cord-022290-p0l1kv6n	236	29	size	size	NN
cord-022290-p0l1kv6n	236	30	of	of	IN
cord-022290-p0l1kv6n	236	31	the	the	DT
cord-022290-p0l1kv6n	236	32	sulfur	sulfur	NN
cord-022290-p0l1kv6n	236	33	nucleophile	nucleophile	NN
cord-022290-p0l1kv6n	236	34	the	the	DT
cord-022290-p0l1kv6n	236	35	active	active	JJ
cord-022290-p0l1kv6n	236	36	site	site	NN
cord-022290-p0l1kv6n	236	37	is	be	VBZ
cord-022290-p0l1kv6n	236	38	larger	large	JJR
cord-022290-p0l1kv6n	236	39	and	and	CC
cord-022290-p0l1kv6n	236	40	the	the	DT
cord-022290-p0l1kv6n	236	41	chemical	chemical	JJ
cord-022290-p0l1kv6n	236	42	groups	group	NNS
cord-022290-p0l1kv6n	236	43	are	be	VBP
cord-022290-p0l1kv6n	236	44	further	further	RB
cord-022290-p0l1kv6n	236	45	apart	apart	RB
cord-022290-p0l1kv6n	236	46	.	.	.
cord-022290-p0l1kv6n	237	1	The	the	DT
cord-022290-p0l1kv6n	237	2	conserved	conserve	VBN
cord-022290-p0l1kv6n	237	3	glycine	glycine	NN
cord-022290-p0l1kv6n	237	4	residue	residue	NN
cord-022290-p0l1kv6n	237	5	in	in	IN
cord-022290-p0l1kv6n	237	6	the	the	DT
cord-022290-p0l1kv6n	237	7	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	237	8	hole	hole	NN
cord-022290-p0l1kv6n	237	9	of	of	IN
cord-022290-p0l1kv6n	237	10	the	the	DT
cord-022290-p0l1kv6n	237	11	wild	wild	JJ
cord-022290-p0l1kv6n	237	12	-	-	HYPH
cord-022290-p0l1kv6n	237	13	type	type	NN
cord-022290-p0l1kv6n	237	14	3C	3C	NNP
cord-022290-p0l1kv6n	237	15	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	237	16	shows	show	VBZ
cord-022290-p0l1kv6n	237	17	a	a	DT
cord-022290-p0l1kv6n	237	18	conformation	conformation	NN
cord-022290-p0l1kv6n	237	19	that	that	WDT
cord-022290-p0l1kv6n	237	20	is	be	VBZ
cord-022290-p0l1kv6n	237	21	similar	similar	JJ
cord-022290-p0l1kv6n	237	22	to	to	IN
cord-022290-p0l1kv6n	237	23	the	the	DT
cord-022290-p0l1kv6n	237	24	one	one	NN
cord-022290-p0l1kv6n	237	25	seen	see	VBN
cord-022290-p0l1kv6n	237	26	for	for	IN
cord-022290-p0l1kv6n	237	27	the	the	DT
cord-022290-p0l1kv6n	237	28	corresponding	corresponding	JJ
cord-022290-p0l1kv6n	237	29	residue	residue	NN
cord-022290-p0l1kv6n	237	30	in	in	IN
cord-022290-p0l1kv6n	237	31	the	the	DT
cord-022290-p0l1kv6n	237	32	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	237	33	-	-	HYPH
cord-022290-p0l1kv6n	237	34	like	like	JJ
cord-022290-p0l1kv6n	237	35	serine	serine	NN
cord-022290-p0l1kv6n	237	36	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	237	37	.	.	.
cord-022290-p0l1kv6n	238	1	This	this	DT
cord-022290-p0l1kv6n	238	2	left	left	RB
cord-022290-p0l1kv6n	238	3	-	-	HYPH
cord-022290-p0l1kv6n	238	4	handed	handed	JJ
cord-022290-p0l1kv6n	238	5	3	3	CD
cord-022290-p0l1kv6n	238	6	~o	~o	JJ
cord-022290-p0l1kv6n	238	7	-	-	HYPH
cord-022290-p0l1kv6n	238	8	helical	helical	JJ
cord-022290-p0l1kv6n	238	9	conformation	conformation	NN
cord-022290-p0l1kv6n	238	10	requires	require	VBZ
cord-022290-p0l1kv6n	238	11	a	a	DT
cord-022290-p0l1kv6n	238	12	glycine	glycine	NN
cord-022290-p0l1kv6n	238	13	in	in	IN
cord-022290-p0l1kv6n	238	14	this	this	DT
cord-022290-p0l1kv6n	238	15	position	position	NN
cord-022290-p0l1kv6n	238	16	(	(	-LRB-
cord-022290-p0l1kv6n	238	17	~	~	NFP
cord-022290-p0l1kv6n	238	18	=	=	SYM
cord-022290-p0l1kv6n	238	19	95	95	CD
cord-022290-p0l1kv6n	238	20	~	~	NFP
cord-022290-p0l1kv6n	238	21	9	9	CD
cord-022290-p0l1kv6n	238	22	=	=	NFP
cord-022290-p0l1kv6n	239	1	-5	-5	NNP
cord-022290-p0l1kv6n	240	1	~	~	NFP
cord-022290-p0l1kv6n	241	1	(	(	-LRB-
cord-022290-p0l1kv6n	241	2	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	241	3	et	et	NNP
cord-022290-p0l1kv6n	241	4	al	al	NNP
cord-022290-p0l1kv6n	241	5	.	.	NNP
cord-022290-p0l1kv6n	241	6	,	,	,
cord-022290-p0l1kv6n	241	7	1997	1997	CD
cord-022290-p0l1kv6n	241	8	)	)	-RRB-
cord-022290-p0l1kv6n	241	9	.	.	.
cord-022290-p0l1kv6n	242	1	In	in	IN
cord-022290-p0l1kv6n	242	2	the	the	DT
cord-022290-p0l1kv6n	242	3	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	242	4	-	-	HYPH
cord-022290-p0l1kv6n	242	5	like	like	JJ
cord-022290-p0l1kv6n	242	6	serine	serine	NN
cord-022290-p0l1kv6n	242	7	proteinases	proteinase	VBZ
cord-022290-p0l1kv6n	242	8	this	this	DT
cord-022290-p0l1kv6n	242	9	conformation	conformation	NN
cord-022290-p0l1kv6n	242	10	is	be	VBZ
cord-022290-p0l1kv6n	242	11	maintained	maintain	VBN
cord-022290-p0l1kv6n	242	12	by	by	IN
cord-022290-p0l1kv6n	242	13	interactions	interaction	NNS
cord-022290-p0l1kv6n	242	14	of	of	IN
cord-022290-p0l1kv6n	242	15	the	the	DT
cord-022290-p0l1kv6n	242	16	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	242	17	of	of	IN
cord-022290-p0l1kv6n	242	18	this	this	DT
cord-022290-p0l1kv6n	242	19	peptide	peptide	NN
cord-022290-p0l1kv6n	242	20	bond	bond	NN
cord-022290-p0l1kv6n	242	21	with	with	IN
cord-022290-p0l1kv6n	242	22	other	other	JJ
cord-022290-p0l1kv6n	242	23	groups	group	NNS
cord-022290-p0l1kv6n	242	24	in	in	IN
cord-022290-p0l1kv6n	242	25	the	the	DT
cord-022290-p0l1kv6n	242	26	structure	structure	NN
cord-022290-p0l1kv6n	242	27	.	.	.
cord-022290-p0l1kv6n	243	1	The	the	DT
cord-022290-p0l1kv6n	243	2	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	243	3	of	of	IN
cord-022290-p0l1kv6n	243	4	the	the	DT
cord-022290-p0l1kv6n	243	5	corresponding	corresponding	JJ
cord-022290-p0l1kv6n	243	6	residue	residue	NN
cord-022290-p0l1kv6n	243	7	in	in	IN
cord-022290-p0l1kv6n	243	8	the	the	DT
cord-022290-p0l1kv6n	243	9	3C	3C	NNP
cord-022290-p0l1kv6n	243	10	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	243	11	(	(	-LRB-
cord-022290-p0l1kv6n	243	12	Pro	Pro	NNP
cord-022290-p0l1kv6n	243	13	169	169	CD
cord-022290-p0l1kv6n	243	14	in	in	IN
cord-022290-p0l1kv6n	243	15	HAV	HAV	NNP
cord-022290-p0l1kv6n	243	16	and	and	CC
cord-022290-p0l1kv6n	243	17	Ala	Ala	NNP
cord-022290-p0l1kv6n	243	18	144	144	CD
cord-022290-p0l1kv6n	243	19	in	in	IN
cord-022290-p0l1kv6n	243	20	PV	PV	NNP
cord-022290-p0l1kv6n	243	21	)	)	-RRB-
cord-022290-p0l1kv6n	243	22	does	do	VBZ
cord-022290-p0l1kv6n	243	23	not	not	RB
cord-022290-p0l1kv6n	243	24	make	make	VB
cord-022290-p0l1kv6n	243	25	any	any	DT
cord-022290-p0l1kv6n	243	26	interactions	interaction	NNS
cord-022290-p0l1kv6n	243	27	in	in	IN
cord-022290-p0l1kv6n	243	28	the	the	DT
cord-022290-p0l1kv6n	243	29	crystal	crystal	NN
cord-022290-p0l1kv6n	243	30	structures	structure	NNS
cord-022290-p0l1kv6n	243	31	.	.	.
cord-022290-p0l1kv6n	244	1	In	in	IN
cord-022290-p0l1kv6n	244	2	the	the	DT
cord-022290-p0l1kv6n	244	3	crystal	crystal	NN
cord-022290-p0l1kv6n	244	4	structures	structure	NNS
cord-022290-p0l1kv6n	244	5	of	of	IN
cord-022290-p0l1kv6n	244	6	mutants	mutant	NNS
cord-022290-p0l1kv6n	244	7	of	of	IN
cord-022290-p0l1kv6n	244	8	the	the	DT
cord-022290-p0l1kv6n	244	9	nucleophilic	nucleophilic	JJ
cord-022290-p0l1kv6n	244	10	cysteine	cysteine	NN
cord-022290-p0l1kv6n	244	11	of	of	IN
cord-022290-p0l1kv6n	244	12	the	the	DT
cord-022290-p0l1kv6n	244	13	HAV	HAV	NNP
cord-022290-p0l1kv6n	244	14	3C	3c	NN
cord-022290-p0l1kv6n	244	15	proteinase	proteinase	NN
cord-022290-p0l1kv6n	244	16	this	this	DT
cord-022290-p0l1kv6n	244	17	peptide	peptide	NN
cord-022290-p0l1kv6n	244	18	bond	bond	NN
cord-022290-p0l1kv6n	244	19	is	be	VBZ
cord-022290-p0l1kv6n	244	20	indeed	indeed	RB
cord-022290-p0l1kv6n	244	21	flipped	flip	VBN
cord-022290-p0l1kv6n	244	22	and	and	CC
cord-022290-p0l1kv6n	244	23	the	the	DT
cord-022290-p0l1kv6n	244	24	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	244	25	hole	hole	NN
cord-022290-p0l1kv6n	244	26	has	have	VBZ
cord-022290-p0l1kv6n	244	27	collapsed	collapse	VBN
cord-022290-p0l1kv6n	244	28	to	to	IN
cord-022290-p0l1kv6n	244	29	a	a	DT
cord-022290-p0l1kv6n	244	30	lower	low	JJR
cord-022290-p0l1kv6n	244	31	energy	energy	NN
cord-022290-p0l1kv6n	244	32	main	main	JJ
cord-022290-p0l1kv6n	244	33	-	-	HYPH
cord-022290-p0l1kv6n	244	34	chain	chain	NN
cord-022290-p0l1kv6n	244	35	conformation	conformation	NN
cord-022290-p0l1kv6n	244	36	(	(	-LRB-
cord-022290-p0l1kv6n	244	37	Allaire	Allaire	NNP
cord-022290-p0l1kv6n	244	38	et	et	NNP
cord-022290-p0l1kv6n	244	39	al	al	NNP
cord-022290-p0l1kv6n	244	40	.	.	NNP
cord-022290-p0l1kv6n	244	41	,	,	,
cord-022290-p0l1kv6n	244	42	1994	1994	CD
cord-022290-p0l1kv6n	244	43	)	)	-RRB-
cord-022290-p0l1kv6n	244	44	.	.	.
cord-022290-p0l1kv6n	245	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	245	2	appears	appear	VBZ
cord-022290-p0l1kv6n	245	3	that	that	IN
cord-022290-p0l1kv6n	245	4	the	the	DT
cord-022290-p0l1kv6n	245	5	presence	presence	NN
cord-022290-p0l1kv6n	245	6	of	of	IN
cord-022290-p0l1kv6n	245	7	the	the	DT
cord-022290-p0l1kv6n	245	8	nucleophilic	nucleophilic	JJ
cord-022290-p0l1kv6n	245	9	sulfur	sulfur	NN
cord-022290-p0l1kv6n	245	10	atom	atom	NN
cord-022290-p0l1kv6n	245	11	itself	-PRON-	PRP
cord-022290-p0l1kv6n	245	12	is	be	VBZ
cord-022290-p0l1kv6n	245	13	required	require	VBN
cord-022290-p0l1kv6n	245	14	to	to	TO
cord-022290-p0l1kv6n	245	15	maintain	maintain	VB
cord-022290-p0l1kv6n	245	16	the	the	DT
cord-022290-p0l1kv6n	245	17	proper	proper	JJ
cord-022290-p0l1kv6n	245	18	conformation	conformation	NN
cord-022290-p0l1kv6n	245	19	of	of	IN
cord-022290-p0l1kv6n	245	20	the	the	DT
cord-022290-p0l1kv6n	245	21	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	245	22	hole	hole	NN
cord-022290-p0l1kv6n	245	23	in	in	IN
cord-022290-p0l1kv6n	245	24	the	the	DT
cord-022290-p0l1kv6n	245	25	3C	3C	NNP
cord-022290-p0l1kv6n	245	26	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	245	27	.	.	.
cord-022290-p0l1kv6n	246	1	We	-PRON-	PRP
cord-022290-p0l1kv6n	246	2	believe	believe	VBP
cord-022290-p0l1kv6n	246	3	that	that	IN
cord-022290-p0l1kv6n	246	4	it	-PRON-	PRP
cord-022290-p0l1kv6n	246	5	is	be	VBZ
cord-022290-p0l1kv6n	246	6	a	a	DT
cord-022290-p0l1kv6n	246	7	negative	negative	JJ
cord-022290-p0l1kv6n	246	8	charge	charge	NN
cord-022290-p0l1kv6n	246	9	on	on	IN
cord-022290-p0l1kv6n	246	10	the	the	DT
cord-022290-p0l1kv6n	246	11	nucleophilic	nucleophilic	JJ
cord-022290-p0l1kv6n	246	12	sulfur	sulfur	NN
cord-022290-p0l1kv6n	246	13	that	that	WDT
cord-022290-p0l1kv6n	246	14	orients	orient	VBZ
cord-022290-p0l1kv6n	246	15	the	the	DT
cord-022290-p0l1kv6n	246	16	peptide	peptide	NN
cord-022290-p0l1kv6n	246	17	bonds	bond	NNS
cord-022290-p0l1kv6n	246	18	of	of	IN
cord-022290-p0l1kv6n	246	19	the	the	DT
cord-022290-p0l1kv6n	246	20	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	246	21	hole	hole	NN
cord-022290-p0l1kv6n	246	22	and	and	CC
cord-022290-p0l1kv6n	246	23	take	take	VB
cord-022290-p0l1kv6n	246	24	this	this	DT
cord-022290-p0l1kv6n	246	25	as	as	IN
cord-022290-p0l1kv6n	246	26	partial	partial	JJ
cord-022290-p0l1kv6n	246	27	evidence	evidence	NN
cord-022290-p0l1kv6n	246	28	for	for	IN
cord-022290-p0l1kv6n	246	29	a	a	DT
cord-022290-p0l1kv6n	246	30	mechanism	mechanism	NN
cord-022290-p0l1kv6n	246	31	involving	involve	VBG
cord-022290-p0l1kv6n	246	32	a	a	DT
cord-022290-p0l1kv6n	246	33	thiolate	thiolate	JJ
cord-022290-p0l1kv6n	246	34	-	-	HYPH
cord-022290-p0l1kv6n	246	35	imidazolium	imidazolium	NN
cord-022290-p0l1kv6n	246	36	ion	ion	NN
cord-022290-p0l1kv6n	246	37	pair	pair	NN
cord-022290-p0l1kv6n	246	38	.	.	.
cord-022290-p0l1kv6n	247	1	Direct	direct	JJ
cord-022290-p0l1kv6n	247	2	experimental	experimental	JJ
cord-022290-p0l1kv6n	247	3	evidence	evidence	NN
cord-022290-p0l1kv6n	247	4	for	for	IN
cord-022290-p0l1kv6n	247	5	the	the	DT
cord-022290-p0l1kv6n	247	6	protonation	protonation	JJ
cord-022290-p0l1kv6n	247	7	state	state	NN
cord-022290-p0l1kv6n	247	8	of	of	IN
cord-022290-p0l1kv6n	247	9	the	the	DT
cord-022290-p0l1kv6n	247	10	residues	residue	NNS
cord-022290-p0l1kv6n	247	11	in	in	IN
cord-022290-p0l1kv6n	247	12	the	the	DT
cord-022290-p0l1kv6n	247	13	active	active	JJ
cord-022290-p0l1kv6n	247	14	site	site	NN
cord-022290-p0l1kv6n	247	15	and	and	CC
cord-022290-p0l1kv6n	247	16	the	the	DT
cord-022290-p0l1kv6n	247	17	mechanism	mechanism	NN
cord-022290-p0l1kv6n	247	18	of	of	IN
cord-022290-p0l1kv6n	247	19	the	the	DT
cord-022290-p0l1kv6n	247	20	3C	3C	NNP
cord-022290-p0l1kv6n	247	21	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	247	22	is	be	VBZ
cord-022290-p0l1kv6n	247	23	,	,	,
cord-022290-p0l1kv6n	247	24	however	however	RB
cord-022290-p0l1kv6n	247	25	,	,	,
cord-022290-p0l1kv6n	247	26	lacking	lack	VBG
cord-022290-p0l1kv6n	247	27	.	.	.
cord-022290-p0l1kv6n	248	1	An	an	DT
cord-022290-p0l1kv6n	248	2	aspartate	aspartate	NN
cord-022290-p0l1kv6n	248	3	or	or	CC
cord-022290-p0l1kv6n	248	4	glutamate	glutamate	NN
cord-022290-p0l1kv6n	248	5	residue	residue	NN
cord-022290-p0l1kv6n	248	6	,	,	,
cord-022290-p0l1kv6n	248	7	which	which	WDT
cord-022290-p0l1kv6n	248	8	is	be	VBZ
cord-022290-p0l1kv6n	248	9	in	in	IN
cord-022290-p0l1kv6n	248	10	an	an	DT
cord-022290-p0l1kv6n	248	11	equivalent	equivalent	JJ
cord-022290-p0l1kv6n	248	12	position	position	NN
cord-022290-p0l1kv6n	248	13	to	to	IN
cord-022290-p0l1kv6n	248	14	the	the	DT
cord-022290-p0l1kv6n	248	15	third	third	JJ
cord-022290-p0l1kv6n	248	16	member	member	NN
cord-022290-p0l1kv6n	248	17	of	of	IN
cord-022290-p0l1kv6n	248	18	the	the	DT
cord-022290-p0l1kv6n	248	19	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	248	20	triad	triad	NN
cord-022290-p0l1kv6n	248	21	of	of	IN
cord-022290-p0l1kv6n	248	22	the	the	DT
cord-022290-p0l1kv6n	248	23	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	248	24	-	-	HYPH
cord-022290-p0l1kv6n	248	25	like	like	JJ
cord-022290-p0l1kv6n	248	26	serine	serine	NN
cord-022290-p0l1kv6n	248	27	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	248	28	,	,	,
cord-022290-p0l1kv6n	248	29	is	be	VBZ
cord-022290-p0l1kv6n	248	30	present	present	JJ
cord-022290-p0l1kv6n	248	31	and	and	CC
cord-022290-p0l1kv6n	248	32	conserved	conserve	VBN
cord-022290-p0l1kv6n	248	33	throughout	throughout	IN
cord-022290-p0l1kv6n	248	34	the	the	DT
cord-022290-p0l1kv6n	248	35	3C	3C	NNP
cord-022290-p0l1kv6n	248	36	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	248	37	(	(	-LRB-
cord-022290-p0l1kv6n	248	38	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	248	39	et	et	NNP
cord-022290-p0l1kv6n	248	40	al	al	NNP
cord-022290-p0l1kv6n	248	41	.	.	NNP
cord-022290-p0l1kv6n	248	42	,	,	,
cord-022290-p0l1kv6n	248	43	1988	1988	CD
cord-022290-p0l1kv6n	248	44	;	;	:
cord-022290-p0l1kv6n	248	45	Ryan	Ryan	NNP
cord-022290-p0l1kv6n	248	46	and	and	CC
cord-022290-p0l1kv6n	248	47	Flint	Flint	NNP
cord-022290-p0l1kv6n	248	48	,	,	,
cord-022290-p0l1kv6n	248	49	1997	1997	CD
cord-022290-p0l1kv6n	248	50	)	)	-RRB-
cord-022290-p0l1kv6n	248	51	.	.	.
cord-022290-p0l1kv6n	249	1	However	however	RB
cord-022290-p0l1kv6n	249	2	,	,	,
cord-022290-p0l1kv6n	249	3	the	the	DT
cord-022290-p0l1kv6n	249	4	interaction	interaction	NN
cord-022290-p0l1kv6n	249	5	typical	typical	JJ
cord-022290-p0l1kv6n	249	6	for	for	IN
cord-022290-p0l1kv6n	249	7	the	the	DT
cord-022290-p0l1kv6n	249	8	third	third	JJ
cord-022290-p0l1kv6n	249	9	member	member	NN
cord-022290-p0l1kv6n	249	10	of	of	IN
cord-022290-p0l1kv6n	249	11	the	the	DT
cord-022290-p0l1kv6n	249	12	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	249	13	triad	triad	NN
cord-022290-p0l1kv6n	249	14	is	be	VBZ
cord-022290-p0l1kv6n	249	15	not	not	RB
cord-022290-p0l1kv6n	249	16	observed	observe	VBN
cord-022290-p0l1kv6n	249	17	.	.	.
cord-022290-p0l1kv6n	250	1	In	in	IN
cord-022290-p0l1kv6n	250	2	HAV	HAV	NNP
cord-022290-p0l1kv6n	250	3	3C	3c	NN
cord-022290-p0l1kv6n	250	4	the	the	DT
cord-022290-p0l1kv6n	250	5	side	side	NN
cord-022290-p0l1kv6n	250	6	-	-	HYPH
cord-022290-p0l1kv6n	250	7	chain	chain	NN
cord-022290-p0l1kv6n	250	8	of	of	IN
cord-022290-p0l1kv6n	250	9	Asp	Asp	NNP
cord-022290-p0l1kv6n	250	10	84	84	CD
cord-022290-p0l1kv6n	250	11	points	point	NNS
cord-022290-p0l1kv6n	250	12	away	away	RB
cord-022290-p0l1kv6n	250	13	from	from	IN
cord-022290-p0l1kv6n	250	14	the	the	DT
cord-022290-p0l1kv6n	250	15	imidazole	imidazole	NN
cord-022290-p0l1kv6n	250	16	of	of	IN
cord-022290-p0l1kv6n	250	17	the	the	DT
cord-022290-p0l1kv6n	250	18	general	general	JJ
cord-022290-p0l1kv6n	250	19	acid	acid	NN
cord-022290-p0l1kv6n	250	20	-	-	HYPH
cord-022290-p0l1kv6n	250	21	base	base	NN
cord-022290-p0l1kv6n	251	1	His	-PRON-	PRP$
cord-022290-p0l1kv6n	251	2	44	44	CD
cord-022290-p0l1kv6n	251	3	.	.	.
cord-022290-p0l1kv6n	252	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	252	2	is	be	VBZ
cord-022290-p0l1kv6n	252	3	locked	lock	VBN
cord-022290-p0l1kv6n	252	4	in	in	IN
cord-022290-p0l1kv6n	252	5	interactions	interaction	NNS
cord-022290-p0l1kv6n	252	6	with	with	IN
cord-022290-p0l1kv6n	252	7	other	other	JJ
cord-022290-p0l1kv6n	252	8	regions	region	NNS
cord-022290-p0l1kv6n	252	9	of	of	IN
cord-022290-p0l1kv6n	252	10	the	the	DT
cord-022290-p0l1kv6n	252	11	structure	structure	NN
cord-022290-p0l1kv6n	252	12	(	(	-LRB-
cord-022290-p0l1kv6n	252	13	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	252	14	et	et	NNP
cord-022290-p0l1kv6n	252	15	al	al	NNP
cord-022290-p0l1kv6n	252	16	.	.	NNP
cord-022290-p0l1kv6n	252	17	,	,	,
cord-022290-p0l1kv6n	252	18	1997	1997	CD
cord-022290-p0l1kv6n	252	19	)	)	-RRB-
cord-022290-p0l1kv6n	252	20	.	.	.
cord-022290-p0l1kv6n	253	1	The	the	DT
cord-022290-p0l1kv6n	253	2	position	position	NN
cord-022290-p0l1kv6n	253	3	of	of	IN
cord-022290-p0l1kv6n	253	4	the	the	DT
cord-022290-p0l1kv6n	253	5	carboxylate	carboxylate	NNP
cord-022290-p0l1kv6n	253	6	of	of	IN
cord-022290-p0l1kv6n	253	7	the	the	DT
cord-022290-p0l1kv6n	253	8	third	third	JJ
cord-022290-p0l1kv6n	253	9	member	member	NN
cord-022290-p0l1kv6n	253	10	of	of	IN
cord-022290-p0l1kv6n	253	11	a	a	DT
cord-022290-p0l1kv6n	253	12	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	253	13	triad	triad	NN
cord-022290-p0l1kv6n	253	14	is	be	VBZ
cord-022290-p0l1kv6n	253	15	taken	take	VBN
cord-022290-p0l1kv6n	253	16	up	up	RP
cord-022290-p0l1kv6n	253	17	by	by	IN
cord-022290-p0l1kv6n	253	18	a	a	DT
cord-022290-p0l1kv6n	253	19	water	water	NN
cord-022290-p0l1kv6n	253	20	molecule	molecule	NN
cord-022290-p0l1kv6n	253	21	in	in	IN
cord-022290-p0l1kv6n	253	22	HAV	HAV	NNP
cord-022290-p0l1kv6n	253	23	3C	3C	NNP
cord-022290-p0l1kv6n	253	24	,	,	,
cord-022290-p0l1kv6n	253	25	which	which	WDT
cord-022290-p0l1kv6n	253	26	forms	form	VBZ
cord-022290-p0l1kv6n	253	27	a	a	DT
cord-022290-p0l1kv6n	253	28	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	253	29	bond	bond	NN
cord-022290-p0l1kv6n	253	30	to	to	IN
cord-022290-p0l1kv6n	253	31	the	the	DT
cord-022290-p0l1kv6n	253	32	N	n	NN
cord-022290-p0l1kv6n	253	33	a	a	NN
cord-022290-p0l1kv6n	253	34	of	of	IN
cord-022290-p0l1kv6n	253	35	His	-PRON-	PRP$
cord-022290-p0l1kv6n	253	36	44	44	CD
cord-022290-p0l1kv6n	253	37	(	(	-LRB-
cord-022290-p0l1kv6n	253	38	Fig	Fig	NNP
cord-022290-p0l1kv6n	253	39	.	.	.
cord-022290-p0l1kv6n	253	40	4a	4a	CD
cord-022290-p0l1kv6n	253	41	)	)	-RRB-
cord-022290-p0l1kv6n	253	42	.	.	.
cord-022290-p0l1kv6n	254	1	This	this	DT
cord-022290-p0l1kv6n	254	2	water	water	NN
cord-022290-p0l1kv6n	254	3	molecule	molecule	NN
cord-022290-p0l1kv6n	254	4	,	,	,
cord-022290-p0l1kv6n	254	5	the	the	DT
cord-022290-p0l1kv6n	254	6	imidazole	imidazole	NN
cord-022290-p0l1kv6n	254	7	of	of	IN
cord-022290-p0l1kv6n	254	8	His	-PRON-	PRP$
cord-022290-p0l1kv6n	254	9	44	44	CD
cord-022290-p0l1kv6n	254	10	and	and	CC
cord-022290-p0l1kv6n	254	11	the	the	DT
cord-022290-p0l1kv6n	254	12	nucleophilic	nucleophilic	JJ
cord-022290-p0l1kv6n	254	13	S	S	NNP
cord-022290-p0l1kv6n	254	14	r	r	NN
cord-022290-p0l1kv6n	254	15	atom	atom	NN
cord-022290-p0l1kv6n	254	16	of	of	IN
cord-022290-p0l1kv6n	254	17	Cys	Cys	NNP
cord-022290-p0l1kv6n	254	18	172	172	CD
cord-022290-p0l1kv6n	254	19	of	of	IN
cord-022290-p0l1kv6n	254	20	HAV	HAV	NNP
cord-022290-p0l1kv6n	254	21	3C	3C	NNP
cord-022290-p0l1kv6n	254	22	are	be	VBP
cord-022290-p0l1kv6n	254	23	in	in	IN
cord-022290-p0l1kv6n	254	24	a	a	DT
cord-022290-p0l1kv6n	254	25	common	common	JJ
cord-022290-p0l1kv6n	254	26	plane	plane	NN
cord-022290-p0l1kv6n	254	27	.	.	.
cord-022290-p0l1kv6n	255	1	Perpendicular	perpendicular	VB
cord-022290-p0l1kv6n	255	2	to	to	IN
cord-022290-p0l1kv6n	255	3	this	this	DT
cord-022290-p0l1kv6n	255	4	plane	plane	NN
cord-022290-p0l1kv6n	255	5	and	and	CC
cord-022290-p0l1kv6n	256	1	3.0A	3.0a	IN
cord-022290-p0l1kv6n	256	2	above	above	IN
cord-022290-p0l1kv6n	256	3	it	-PRON-	PRP
cord-022290-p0l1kv6n	256	4	,	,	,
cord-022290-p0l1kv6n	256	5	is	be	VBZ
cord-022290-p0l1kv6n	256	6	the	the	DT
cord-022290-p0l1kv6n	256	7	sidechain	sidechain	NN
cord-022290-p0l1kv6n	256	8	of	of	IN
cord-022290-p0l1kv6n	256	9	Tyr	Tyr	NNP
cord-022290-p0l1kv6n	256	10	143	143	CD
cord-022290-p0l1kv6n	256	11	,	,	,
cord-022290-p0l1kv6n	256	12	which	which	WDT
cord-022290-p0l1kv6n	256	13	is	be	VBZ
cord-022290-p0l1kv6n	256	14	located	locate	VBN
cord-022290-p0l1kv6n	256	15	in	in	IN
cord-022290-p0l1kv6n	256	16	the	the	DT
cord-022290-p0l1kv6n	256	17	antiparallel	antiparallel	NN
cord-022290-p0l1kv6n	256	18	fi	fi	NN
cord-022290-p0l1kv6n	256	19	-	-	HYPH
cord-022290-p0l1kv6n	256	20	ribbon	ribbon	NN
cord-022290-p0l1kv6n	256	21	of	of	IN
cord-022290-p0l1kv6n	256	22	HAV	HAV	NNP
cord-022290-p0l1kv6n	256	23	3C.	3c.	CD
cord-022290-p0l1kv6n	256	24	Mutational	Mutational	NNP
cord-022290-p0l1kv6n	256	25	studies	study	NNS
cord-022290-p0l1kv6n	256	26	have	have	VBP
cord-022290-p0l1kv6n	256	27	shown	show	VBN
cord-022290-p0l1kv6n	256	28	that	that	IN
cord-022290-p0l1kv6n	256	29	Tyr	Tyr	NNP
cord-022290-p0l1kv6n	256	30	143	143	CD
cord-022290-p0l1kv6n	256	31	is	be	VBZ
cord-022290-p0l1kv6n	256	32	important	important	JJ
cord-022290-p0l1kv6n	256	33	for	for	IN
cord-022290-p0l1kv6n	256	34	the	the	DT
cord-022290-p0l1kv6n	256	35	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	256	36	activity	activity	NN
cord-022290-p0l1kv6n	256	37	of	of	IN
cord-022290-p0l1kv6n	256	38	HAV	HAV	NNP
cord-022290-p0l1kv6n	256	39	3C.	3c.	CD
cord-022290-p0l1kv6n	257	1	The	the	DT
cord-022290-p0l1kv6n	257	2	side	side	NN
cord-022290-p0l1kv6n	257	3	-	-	HYPH
cord-022290-p0l1kv6n	257	4	chain	chain	NN
cord-022290-p0l1kv6n	257	5	of	of	IN
cord-022290-p0l1kv6n	257	6	Tyr	Tyr	NNP
cord-022290-p0l1kv6n	257	7	143	143	CD
cord-022290-p0l1kv6n	257	8	does	do	VBZ
cord-022290-p0l1kv6n	257	9	not	not	RB
cord-022290-p0l1kv6n	257	10	form	form	VB
cord-022290-p0l1kv6n	257	11	a	a	DT
cord-022290-p0l1kv6n	257	12	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	257	13	bond	bond	NN
cord-022290-p0l1kv6n	257	14	in	in	IN
cord-022290-p0l1kv6n	257	15	the	the	DT
cord-022290-p0l1kv6n	257	16	crystal	crystal	JJ
cord-022290-p0l1kv6n	257	17	structure	structure	NN
cord-022290-p0l1kv6n	257	18	of	of	IN
cord-022290-p0l1kv6n	257	19	HAV	HAV	NNP
cord-022290-p0l1kv6n	257	20	3C.	3c.	CD
cord-022290-p0l1kv6n	258	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	258	2	is	be	VBZ
cord-022290-p0l1kv6n	258	3	perpendicular	perpendicular	JJ
cord-022290-p0l1kv6n	258	4	to	to	IN
cord-022290-p0l1kv6n	258	5	the	the	DT
cord-022290-p0l1kv6n	258	6	plane	plane	NN
cord-022290-p0l1kv6n	258	7	of	of	IN
cord-022290-p0l1kv6n	258	8	the	the	DT
cord-022290-p0l1kv6n	258	9	imidazole	imidazole	NN
cord-022290-p0l1kv6n	258	10	and	and	CC
cord-022290-p0l1kv6n	258	11	it	-PRON-	PRP
cord-022290-p0l1kv6n	258	12	is	be	VBZ
cord-022290-p0l1kv6n	258	13	3.5A	3.5a	NN
cord-022290-p0l1kv6n	258	14	away	away	RB
cord-022290-p0l1kv6n	258	15	from	from	IN
cord-022290-p0l1kv6n	258	16	the	the	DT
cord-022290-p0l1kv6n	258	17	water	water	NN
cord-022290-p0l1kv6n	258	18	molecule	molecule	NN
cord-022290-p0l1kv6n	258	19	.	.	.
cord-022290-p0l1kv6n	259	1	We	-PRON-	PRP
cord-022290-p0l1kv6n	259	2	believe	believe	VBP
cord-022290-p0l1kv6n	259	3	the	the	DT
cord-022290-p0l1kv6n	259	4	side	side	NN
cord-022290-p0l1kv6n	259	5	-	-	HYPH
cord-022290-p0l1kv6n	259	6	chain	chain	NN
cord-022290-p0l1kv6n	259	7	of	of	IN
cord-022290-p0l1kv6n	259	8	Tyr	Tyr	NNP
cord-022290-p0l1kv6n	259	9	143	143	CD
cord-022290-p0l1kv6n	259	10	is	be	VBZ
cord-022290-p0l1kv6n	259	11	deprotonated	deprotonated	JJ
cord-022290-p0l1kv6n	259	12	and	and	CC
cord-022290-p0l1kv6n	259	13	negatively	negatively	RB
cord-022290-p0l1kv6n	259	14	charged	charge	VBN
cord-022290-p0l1kv6n	259	15	in	in	IN
cord-022290-p0l1kv6n	259	16	the	the	DT
cord-022290-p0l1kv6n	259	17	structure	structure	NN
cord-022290-p0l1kv6n	259	18	of	of	IN
cord-022290-p0l1kv6n	259	19	the	the	DT
cord-022290-p0l1kv6n	259	20	HAV	HAV	NNP
cord-022290-p0l1kv6n	259	21	3C	3c	NN
cord-022290-p0l1kv6n	259	22	proteinase	proteinase	NN
cord-022290-p0l1kv6n	259	23	.	.	.
cord-022290-p0l1kv6n	260	1	Presumably	presumably	RB
cord-022290-p0l1kv6n	260	2	,	,	,
cord-022290-p0l1kv6n	260	3	an	an	DT
cord-022290-p0l1kv6n	260	4	electrostatic	electrostatic	JJ
cord-022290-p0l1kv6n	260	5	interaction	interaction	NN
cord-022290-p0l1kv6n	260	6	between	between	IN
cord-022290-p0l1kv6n	260	7	His	-PRON-	PRP$
cord-022290-p0l1kv6n	260	8	44	44	CD
cord-022290-p0l1kv6n	260	9	and	and	CC
cord-022290-p0l1kv6n	260	10	Tyr	Tyr	NNP
cord-022290-p0l1kv6n	260	11	143	143	CD
cord-022290-p0l1kv6n	260	12	helps	help	VBZ
cord-022290-p0l1kv6n	260	13	to	to	TO
cord-022290-p0l1kv6n	260	14	maintain	maintain	VB
cord-022290-p0l1kv6n	260	15	the	the	DT
cord-022290-p0l1kv6n	260	16	side	side	NN
cord-022290-p0l1kv6n	260	17	-	-	HYPH
cord-022290-p0l1kv6n	260	18	chain	chain	NN
cord-022290-p0l1kv6n	260	19	conformation	conformation	NN
cord-022290-p0l1kv6n	260	20	of	of	IN
cord-022290-p0l1kv6n	260	21	His	-PRON-	PRP$
cord-022290-p0l1kv6n	260	22	44	44	CD
cord-022290-p0l1kv6n	260	23	with	with	IN
cord-022290-p0l1kv6n	260	24	the	the	DT
cord-022290-p0l1kv6n	260	25	imidazole	imidazole	NN
cord-022290-p0l1kv6n	260	26	in	in	IN
cord-022290-p0l1kv6n	260	27	the	the	DT
cord-022290-p0l1kv6n	260	28	same	same	JJ
cord-022290-p0l1kv6n	260	29	plane	plane	NN
cord-022290-p0l1kv6n	260	30	as	as	IN
cord-022290-p0l1kv6n	260	31	the	the	DT
cord-022290-p0l1kv6n	260	32	nucleophilic	nucleophilic	JJ
cord-022290-p0l1kv6n	260	33	S	S	NNP
cord-022290-p0l1kv6n	260	34	~	~	CD
cord-022290-p0l1kv6n	260	35	atom	atom	NN
cord-022290-p0l1kv6n	260	36	of	of	IN
cord-022290-p0l1kv6n	260	37	Cys	Cys	NNP
cord-022290-p0l1kv6n	260	38	172	172	CD
cord-022290-p0l1kv6n	260	39	and	and	CC
cord-022290-p0l1kv6n	260	40	helps	help	VBZ
cord-022290-p0l1kv6n	260	41	to	to	TO
cord-022290-p0l1kv6n	260	42	stabilize	stabilize	VB
cord-022290-p0l1kv6n	260	43	a	a	DT
cord-022290-p0l1kv6n	260	44	positive	positive	JJ
cord-022290-p0l1kv6n	260	45	charge	charge	NN
cord-022290-p0l1kv6n	260	46	on	on	IN
cord-022290-p0l1kv6n	260	47	the	the	DT
cord-022290-p0l1kv6n	260	48	His	-PRON-	PRP$
cord-022290-p0l1kv6n	260	49	44	44	CD
cord-022290-p0l1kv6n	260	50	imidazole	imidazole	NN
cord-022290-p0l1kv6n	260	51	.	.	.
cord-022290-p0l1kv6n	261	1	The	the	DT
cord-022290-p0l1kv6n	261	2	conserved	conserve	VBN
cord-022290-p0l1kv6n	261	3	glutamate	glutamate	NN
cord-022290-p0l1kv6n	261	4	,	,	,
cord-022290-p0l1kv6n	261	5	which	which	WDT
cord-022290-p0l1kv6n	261	6	is	be	VBZ
cord-022290-p0l1kv6n	261	7	present	present	JJ
cord-022290-p0l1kv6n	261	8	in	in	IN
cord-022290-p0l1kv6n	261	9	the	the	DT
cord-022290-p0l1kv6n	261	10	position	position	NN
cord-022290-p0l1kv6n	261	11	that	that	WDT
cord-022290-p0l1kv6n	261	12	corresponds	correspond	VBZ
cord-022290-p0l1kv6n	261	13	to	to	IN
cord-022290-p0l1kv6n	261	14	the	the	DT
cord-022290-p0l1kv6n	261	15	third	third	JJ
cord-022290-p0l1kv6n	261	16	member	member	NN
cord-022290-p0l1kv6n	261	17	of	of	IN
cord-022290-p0l1kv6n	261	18	a	a	DT
cord-022290-p0l1kv6n	261	19	putative	putative	JJ
cord-022290-p0l1kv6n	261	20	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	261	21	triad	triad	NN
cord-022290-p0l1kv6n	261	22	in	in	IN
cord-022290-p0l1kv6n	261	23	polio	polio	NNP
cord-022290-p0l1kv6n	261	24	virus	virus	NN
cord-022290-p0l1kv6n	261	25	3C	3C	NNP
cord-022290-p0l1kv6n	261	26	(	(	-LRB-
cord-022290-p0l1kv6n	261	27	Glu	Glu	NNP
cord-022290-p0l1kv6n	261	28	71	71	CD
cord-022290-p0l1kv6n	261	29	)	)	-RRB-
cord-022290-p0l1kv6n	261	30	,	,	,
cord-022290-p0l1kv6n	261	31	does	do	VBZ
cord-022290-p0l1kv6n	261	32	interact	interact	VB
cord-022290-p0l1kv6n	261	33	with	with	IN
cord-022290-p0l1kv6n	261	34	the	the	DT
cord-022290-p0l1kv6n	261	35	imidazole	imidazole	NN
cord-022290-p0l1kv6n	261	36	of	of	IN
cord-022290-p0l1kv6n	261	37	the	the	DT
cord-022290-p0l1kv6n	261	38	general	general	JJ
cord-022290-p0l1kv6n	261	39	acid	acid	NN
cord-022290-p0l1kv6n	261	40	-	-	HYPH
cord-022290-p0l1kv6n	261	41	base	base	NN
cord-022290-p0l1kv6n	261	42	catalyst	catalyst	NN
cord-022290-p0l1kv6n	262	1	His	-PRON-	PRP$
cord-022290-p0l1kv6n	262	2	40	40	CD
cord-022290-p0l1kv6n	262	3	.	.	.
cord-022290-p0l1kv6n	263	1	The	the	DT
cord-022290-p0l1kv6n	263	2	interaction	interaction	NN
cord-022290-p0l1kv6n	263	3	is	be	VBZ
cord-022290-p0l1kv6n	263	4	,	,	,
cord-022290-p0l1kv6n	263	5	however	however	RB
cord-022290-p0l1kv6n	263	6	,	,	,
cord-022290-p0l1kv6n	263	7	unusual	unusual	JJ
cord-022290-p0l1kv6n	263	8	.	.	.
cord-022290-p0l1kv6n	264	1	Accepting	accept	VBG
cord-022290-p0l1kv6n	264	2	a	a	DT
cord-022290-p0l1kv6n	264	3	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	264	4	bond	bond	NN
cord-022290-p0l1kv6n	264	5	from	from	IN
cord-022290-p0l1kv6n	264	6	the	the	DT
cord-022290-p0l1kv6n	264	7	N	N	NNP
cord-022290-p0l1kv6n	264	8	a	a	DT
cord-022290-p0l1kv6n	264	9	atom	atom	NN
cord-022290-p0l1kv6n	264	10	of	of	IN
cord-022290-p0l1kv6n	264	11	His	-PRON-	PRP$
cord-022290-p0l1kv6n	264	12	44	44	CD
cord-022290-p0l1kv6n	264	13	is	be	VBZ
cord-022290-p0l1kv6n	264	14	the	the	DT
cord-022290-p0l1kv6n	264	15	anti	anti	JJ
cord-022290-p0l1kv6n	264	16	lone	lone	NN
cord-022290-p0l1kv6n	264	17	electron	electron	NN
cord-022290-p0l1kv6n	264	18	pair	pair	NN
cord-022290-p0l1kv6n	264	19	of	of	IN
cord-022290-p0l1kv6n	264	20	the	the	DT
cord-022290-p0l1kv6n	264	21	carboxylate	carboxylate	NN
cord-022290-p0l1kv6n	264	22	of	of	IN
cord-022290-p0l1kv6n	264	23	Glu	Glu	NNP
cord-022290-p0l1kv6n	264	24	71	71	CD
cord-022290-p0l1kv6n	264	25	.	.	.
cord-022290-p0l1kv6n	265	1	This	this	DT
cord-022290-p0l1kv6n	265	2	is	be	VBZ
cord-022290-p0l1kv6n	265	3	similar	similar	JJ
cord-022290-p0l1kv6n	265	4	to	to	IN
cord-022290-p0l1kv6n	265	5	the	the	DT
cord-022290-p0l1kv6n	265	6	structure	structure	NN
cord-022290-p0l1kv6n	265	7	of	of	IN
cord-022290-p0l1kv6n	265	8	the	the	DT
cord-022290-p0l1kv6n	265	9	3C	3C	NNP
cord-022290-p0l1kv6n	265	10	proteinase	proteinase	NN
cord-022290-p0l1kv6n	265	11	from	from	IN
cord-022290-p0l1kv6n	265	12	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	265	13	(	(	-LRB-
cord-022290-p0l1kv6n	265	14	Matthews	Matthews	NNP
cord-022290-p0l1kv6n	265	15	et	et	NNP
cord-022290-p0l1kv6n	265	16	al	al	NNP
cord-022290-p0l1kv6n	265	17	.	.	NNP
cord-022290-p0l1kv6n	265	18	,	,	,
cord-022290-p0l1kv6n	265	19	1997	1997	CD
cord-022290-p0l1kv6n	265	20	)	)	-RRB-
cord-022290-p0l1kv6n	265	21	.	.	.
cord-022290-p0l1kv6n	266	1	Thus	thus	RB
cord-022290-p0l1kv6n	266	2	,	,	,
cord-022290-p0l1kv6n	266	3	the	the	DT
cord-022290-p0l1kv6n	266	4	conserved	conserve	VBN
cord-022290-p0l1kv6n	266	5	features	feature	NNS
cord-022290-p0l1kv6n	266	6	in	in	IN
cord-022290-p0l1kv6n	266	7	the	the	DT
cord-022290-p0l1kv6n	266	8	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	266	9	active	active	JJ
cord-022290-p0l1kv6n	266	10	site	site	NN
cord-022290-p0l1kv6n	266	11	of	of	IN
cord-022290-p0l1kv6n	266	12	the	the	DT
cord-022290-p0l1kv6n	266	13	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	266	14	3C	3C	NNP
cord-022290-p0l1kv6n	266	15	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	266	16	are	be	VBP
cord-022290-p0l1kv6n	266	17	a	a	DT
cord-022290-p0l1kv6n	266	18	cysteine	cysteine	NN
cord-022290-p0l1kv6n	266	19	-	-	HYPH
cord-022290-p0l1kv6n	266	20	histidine	histidine	NN
cord-022290-p0l1kv6n	266	21	dyad	dyad	NN
cord-022290-p0l1kv6n	266	22	and	and	CC
cord-022290-p0l1kv6n	266	23	an	an	DT
cord-022290-p0l1kv6n	266	24	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	266	25	hole	hole	NN
cord-022290-p0l1kv6n	266	26	that	that	WDT
cord-022290-p0l1kv6n	266	27	resembles	resemble	VBZ
cord-022290-p0l1kv6n	266	28	that	that	DT
cord-022290-p0l1kv6n	266	29	of	of	IN
cord-022290-p0l1kv6n	266	30	the	the	DT
cord-022290-p0l1kv6n	266	31	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	266	32	-	-	HYPH
cord-022290-p0l1kv6n	266	33	like	like	JJ
cord-022290-p0l1kv6n	266	34	serine	serine	NN
cord-022290-p0l1kv6n	266	35	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	266	36	remarkably	remarkably	RB
cord-022290-p0l1kv6n	266	37	well	well	RB
cord-022290-p0l1kv6n	266	38	.	.	.
cord-022290-p0l1kv6n	267	1	Additional	additional	JJ
cord-022290-p0l1kv6n	267	2	chemical	chemical	NN
cord-022290-p0l1kv6n	267	3	groups	group	NNS
cord-022290-p0l1kv6n	267	4	have	have	VBP
cord-022290-p0l1kv6n	267	5	been	be	VBN
cord-022290-p0l1kv6n	267	6	shown	show	VBN
cord-022290-p0l1kv6n	267	7	to	to	TO
cord-022290-p0l1kv6n	267	8	be	be	VB
cord-022290-p0l1kv6n	267	9	important	important	JJ
cord-022290-p0l1kv6n	267	10	by	by	IN
cord-022290-p0l1kv6n	267	11	mutagenesis	mutagenesis	NN
cord-022290-p0l1kv6n	267	12	experiments	experiment	NNS
cord-022290-p0l1kv6n	267	13	and	and	CC
cord-022290-p0l1kv6n	267	14	are	be	VBP
cord-022290-p0l1kv6n	267	15	making	make	VBG
cord-022290-p0l1kv6n	267	16	interactions	interaction	NNS
cord-022290-p0l1kv6n	267	17	with	with	IN
cord-022290-p0l1kv6n	267	18	mostly	mostly	RB
cord-022290-p0l1kv6n	267	19	the	the	DT
cord-022290-p0l1kv6n	267	20	histidine	histidine	NN
cord-022290-p0l1kv6n	267	21	general	general	JJ
cord-022290-p0l1kv6n	267	22	acid	acid	NN
cord-022290-p0l1kv6n	267	23	-	-	HYPH
cord-022290-p0l1kv6n	267	24	base	base	NN
cord-022290-p0l1kv6n	267	25	catalyst	catalyst	NN
cord-022290-p0l1kv6n	267	26	.	.	.
cord-022290-p0l1kv6n	268	1	Their	-PRON-	PRP$
cord-022290-p0l1kv6n	268	2	function	function	NN
cord-022290-p0l1kv6n	268	3	is	be	VBZ
cord-022290-p0l1kv6n	268	4	probably	probably	RB
cord-022290-p0l1kv6n	268	5	to	to	TO
cord-022290-p0l1kv6n	268	6	maintain	maintain	VB
cord-022290-p0l1kv6n	268	7	the	the	DT
cord-022290-p0l1kv6n	268	8	orientation	orientation	NN
cord-022290-p0l1kv6n	268	9	of	of	IN
cord-022290-p0l1kv6n	268	10	the	the	DT
cord-022290-p0l1kv6n	268	11	active	active	JJ
cord-022290-p0l1kv6n	268	12	site	site	NN
cord-022290-p0l1kv6n	268	13	residues	residue	NNS
cord-022290-p0l1kv6n	268	14	and	and	CC
cord-022290-p0l1kv6n	268	15	to	to	TO
cord-022290-p0l1kv6n	268	16	provide	provide	VB
cord-022290-p0l1kv6n	268	17	a	a	DT
cord-022290-p0l1kv6n	268	18	specific	specific	JJ
cord-022290-p0l1kv6n	268	19	electrostatic	electrostatic	JJ
cord-022290-p0l1kv6n	268	20	environment	environment	NN
cord-022290-p0l1kv6n	268	21	.	.	.
cord-022290-p0l1kv6n	269	1	Chymotrypsin	Chymotrypsin	NNP
cord-022290-p0l1kv6n	269	2	-	-	HYPH
cord-022290-p0l1kv6n	269	3	like	like	JJ
cord-022290-p0l1kv6n	269	4	serine	serine	NN
cord-022290-p0l1kv6n	269	5	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	269	6	bind	bind	VBP
cord-022290-p0l1kv6n	269	7	specific	specific	JJ
cord-022290-p0l1kv6n	269	8	substrates	substrate	NNS
cord-022290-p0l1kv6n	269	9	in	in	IN
cord-022290-p0l1kv6n	269	10	a	a	DT
cord-022290-p0l1kv6n	269	11	canonical	canonical	JJ
cord-022290-p0l1kv6n	269	12	mode	mode	NN
cord-022290-p0l1kv6n	269	13	and	and	CC
cord-022290-p0l1kv6n	269	14	with	with	IN
cord-022290-p0l1kv6n	269	15	a	a	DT
cord-022290-p0l1kv6n	269	16	specific	specific	JJ
cord-022290-p0l1kv6n	269	17	conformation	conformation	NN
cord-022290-p0l1kv6n	269	18	of	of	IN
cord-022290-p0l1kv6n	269	19	the	the	DT
cord-022290-p0l1kv6n	269	20	bound	bind	VBN
cord-022290-p0l1kv6n	269	21	peptide	peptide	NN
cord-022290-p0l1kv6n	269	22	substrate	substrate	NN
cord-022290-p0l1kv6n	269	23	(	(	-LRB-
cord-022290-p0l1kv6n	269	24	Read	Read	NNP
cord-022290-p0l1kv6n	269	25	and	and	CC
cord-022290-p0l1kv6n	269	26	James	James	NNP
cord-022290-p0l1kv6n	269	27	,	,	,
cord-022290-p0l1kv6n	269	28	1986	1986	CD
cord-022290-p0l1kv6n	269	29	;	;	:
cord-022290-p0l1kv6n	269	30	Bode	Bode	NNP
cord-022290-p0l1kv6n	269	31	and	and	CC
cord-022290-p0l1kv6n	269	32	Huber	Huber	NNP
cord-022290-p0l1kv6n	269	33	,	,	,
cord-022290-p0l1kv6n	269	34	1992	1992	CD
cord-022290-p0l1kv6n	269	35	)	)	-RRB-
cord-022290-p0l1kv6n	269	36	.	.	.
cord-022290-p0l1kv6n	270	1	We	-PRON-	PRP
cord-022290-p0l1kv6n	270	2	now	now	RB
cord-022290-p0l1kv6n	270	3	have	have	VBP
cord-022290-p0l1kv6n	270	4	evidence	evidence	NN
cord-022290-p0l1kv6n	270	5	from	from	IN
cord-022290-p0l1kv6n	270	6	structures	structure	NNS
cord-022290-p0l1kv6n	270	7	of	of	IN
cord-022290-p0l1kv6n	270	8	enzyme	enzyme	NN
cord-022290-p0l1kv6n	270	9	inhibitor	inhibitor	NN
cord-022290-p0l1kv6n	270	10	complexes	complex	NNS
cord-022290-p0l1kv6n	270	11	that	that	WDT
cord-022290-p0l1kv6n	270	12	the	the	DT
cord-022290-p0l1kv6n	270	13	3C	3C	NNP
cord-022290-p0l1kv6n	270	14	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	270	15	bind	bind	VBP
cord-022290-p0l1kv6n	270	16	peptide	peptide	NN
cord-022290-p0l1kv6n	270	17	substrates	substrate	NNS
cord-022290-p0l1kv6n	270	18	in	in	IN
cord-022290-p0l1kv6n	270	19	a	a	DT
cord-022290-p0l1kv6n	270	20	similar	similar	JJ
cord-022290-p0l1kv6n	270	21	conformation	conformation	NN
cord-022290-p0l1kv6n	270	22	(	(	-LRB-
cord-022290-p0l1kv6n	270	23	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	270	24	and	and	CC
cord-022290-p0l1kv6n	270	25	James	James	NNP
cord-022290-p0l1kv6n	270	26	,	,	,
cord-022290-p0l1kv6n	270	27	manuscript	manuscript	NN
cord-022290-p0l1kv6n	270	28	in	in	IN
cord-022290-p0l1kv6n	270	29	preparation	preparation	NN
cord-022290-p0l1kv6n	270	30	)	)	-RRB-
cord-022290-p0l1kv6n	270	31	.	.	.
cord-022290-p0l1kv6n	271	1	Furthermore	furthermore	RB
cord-022290-p0l1kv6n	271	2	,	,	,
cord-022290-p0l1kv6n	271	3	the	the	DT
cord-022290-p0l1kv6n	271	4	specific	specific	JJ
cord-022290-p0l1kv6n	271	5	recognition	recognition	NN
cord-022290-p0l1kv6n	271	6	of	of	IN
cord-022290-p0l1kv6n	271	7	the	the	DT
cord-022290-p0l1kv6n	271	8	cleavage	cleavage	NN
cord-022290-p0l1kv6n	271	9	sites	site	NNS
cord-022290-p0l1kv6n	271	10	within	within	IN
cord-022290-p0l1kv6n	271	11	the	the	DT
cord-022290-p0l1kv6n	271	12	viral	viral	JJ
cord-022290-p0l1kv6n	271	13	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	271	14	by	by	IN
cord-022290-p0l1kv6n	271	15	the	the	DT
cord-022290-p0l1kv6n	271	16	3C	3C	NNP
cord-022290-p0l1kv6n	271	17	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	271	18	can	can	MD
cord-022290-p0l1kv6n	271	19	be	be	VB
cord-022290-p0l1kv6n	271	20	rationalized	rationalize	VBN
cord-022290-p0l1kv6n	271	21	if	if	IN
cord-022290-p0l1kv6n	271	22	one	one	PRP
cord-022290-p0l1kv6n	271	23	assumes	assume	VBZ
cord-022290-p0l1kv6n	271	24	a	a	DT
cord-022290-p0l1kv6n	271	25	similar	similar	JJ
cord-022290-p0l1kv6n	271	26	binding	binding	NN
cord-022290-p0l1kv6n	271	27	mode	mode	NN
cord-022290-p0l1kv6n	271	28	.	.	.
cord-022290-p0l1kv6n	272	1	Chymotrypsin	Chymotrypsin	NNP
cord-022290-p0l1kv6n	272	2	-	-	HYPH
cord-022290-p0l1kv6n	272	3	like	like	JJ
cord-022290-p0l1kv6n	272	4	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	272	5	specifically	specifically	RB
cord-022290-p0l1kv6n	272	6	bind	bind	VBP
cord-022290-p0l1kv6n	272	7	4	4	CD
cord-022290-p0l1kv6n	272	8	-	-	SYM
cord-022290-p0l1kv6n	272	9	5	5	CD
cord-022290-p0l1kv6n	272	10	residues	residue	NNS
cord-022290-p0l1kv6n	272	11	that	that	WDT
cord-022290-p0l1kv6n	272	12	precede	precede	VBP
cord-022290-p0l1kv6n	272	13	the	the	DT
cord-022290-p0l1kv6n	272	14	scissile	scissile	NNP
cord-022290-p0l1kv6n	272	15	bond	bond	NN
cord-022290-p0l1kv6n	272	16	and	and	CC
cord-022290-p0l1kv6n	272	17	2	2	CD
cord-022290-p0l1kv6n	272	18	-	-	SYM
cord-022290-p0l1kv6n	272	19	3	3	CD
cord-022290-p0l1kv6n	272	20	residues	residue	NNS
cord-022290-p0l1kv6n	272	21	that	that	WDT
cord-022290-p0l1kv6n	272	22	follow	follow	VBP
cord-022290-p0l1kv6n	272	23	it	-PRON-	PRP
cord-022290-p0l1kv6n	272	24	in	in	IN
cord-022290-p0l1kv6n	272	25	the	the	DT
cord-022290-p0l1kv6n	272	26	sequence	sequence	NN
cord-022290-p0l1kv6n	272	27	(	(	-LRB-
cord-022290-p0l1kv6n	272	28	i.e.	i.e.	FW
cord-022290-p0l1kv6n	272	29	,	,	,
cord-022290-p0l1kv6n	272	30	P5	p5	NN
cord-022290-p0l1kv6n	272	31	to	to	IN
cord-022290-p0l1kv6n	272	32	P~	P~	NNP
cord-022290-p0l1kv6n	272	33	)	)	-RRB-
cord-022290-p0l1kv6n	272	34	.	.	.
cord-022290-p0l1kv6n	273	1	The	the	DT
cord-022290-p0l1kv6n	273	2	residues	residue	NNS
cord-022290-p0l1kv6n	273	3	from	from	IN
cord-022290-p0l1kv6n	273	4	P5	p5	NN
cord-022290-p0l1kv6n	273	5	to	to	IN
cord-022290-p0l1kv6n	273	6	P2	p2	NN
cord-022290-p0l1kv6n	273	7	of	of	IN
cord-022290-p0l1kv6n	273	8	the	the	DT
cord-022290-p0l1kv6n	273	9	substrate	substrate	NN
cord-022290-p0l1kv6n	273	10	are	be	VBP
cord-022290-p0l1kv6n	273	11	usually	usually	RB
cord-022290-p0l1kv6n	273	12	in	in	IN
cord-022290-p0l1kv6n	273	13	a/3-strand	a/3-strand	NNP
cord-022290-p0l1kv6n	273	14	conformation	conformation	NN
cord-022290-p0l1kv6n	273	15	.	.	.
cord-022290-p0l1kv6n	274	1	The	the	DT
cord-022290-p0l1kv6n	274	2	P1	P1	NNP
cord-022290-p0l1kv6n	274	3	residue	residue	NN
cord-022290-p0l1kv6n	274	4	adopts	adopt	VBZ
cord-022290-p0l1kv6n	274	5	a	a	DT
cord-022290-p0l1kv6n	274	6	main	main	JJ
cord-022290-p0l1kv6n	274	7	-	-	HYPH
cord-022290-p0l1kv6n	274	8	chain	chain	NN
cord-022290-p0l1kv6n	274	9	conformation	conformation	NN
cord-022290-p0l1kv6n	274	10	that	that	WDT
cord-022290-p0l1kv6n	274	11	corresponds	correspond	VBZ
cord-022290-p0l1kv6n	274	12	to	to	IN
cord-022290-p0l1kv6n	274	13	a	a	DT
cord-022290-p0l1kv6n	274	14	tight	tight	JJ
cord-022290-p0l1kv6n	274	15	31o	31o	CD
cord-022290-p0l1kv6n	274	16	helix	helix	NN
cord-022290-p0l1kv6n	274	17	.	.	.
cord-022290-p0l1kv6n	275	1	This	this	DT
cord-022290-p0l1kv6n	275	2	places	place	VBZ
cord-022290-p0l1kv6n	275	3	the	the	DT
cord-022290-p0l1kv6n	275	4	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	275	5	of	of	IN
cord-022290-p0l1kv6n	275	6	the	the	DT
cord-022290-p0l1kv6n	275	7	scissile	scissile	NNP
cord-022290-p0l1kv6n	275	8	peptide	peptide	NNP
cord-022290-p0l1kv6n	275	9	bond	bond	NN
cord-022290-p0l1kv6n	275	10	into	into	IN
cord-022290-p0l1kv6n	275	11	the	the	DT
cord-022290-p0l1kv6n	275	12	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	275	13	hole	hole	NN
cord-022290-p0l1kv6n	275	14	.	.	.
cord-022290-p0l1kv6n	276	1	The	the	DT
cord-022290-p0l1kv6n	276	2	P'I	p'i	NN
cord-022290-p0l1kv6n	276	3	and	and	CC
cord-022290-p0l1kv6n	276	4	P2	P2	NNP
cord-022290-p0l1kv6n	276	5	residues	residue	NNS
cord-022290-p0l1kv6n	276	6	are	be	VBP
cord-022290-p0l1kv6n	276	7	usually	usually	RB
cord-022290-p0l1kv6n	276	8	also	also	RB
cord-022290-p0l1kv6n	276	9	in	in	IN
cord-022290-p0l1kv6n	276	10	a	a	DT
cord-022290-p0l1kv6n	276	11	/	/	SYM
cord-022290-p0l1kv6n	276	12	t	t	NN
cord-022290-p0l1kv6n	276	13	-	-	HYPH
cord-022290-p0l1kv6n	276	14	conformation	conformation	NN
cord-022290-p0l1kv6n	276	15	.	.	.
cord-022290-p0l1kv6n	277	1	This	this	DT
cord-022290-p0l1kv6n	277	2	main	main	JJ
cord-022290-p0l1kv6n	277	3	chain	chain	NN
cord-022290-p0l1kv6n	277	4	conformation	conformation	NN
cord-022290-p0l1kv6n	277	5	of	of	IN
cord-022290-p0l1kv6n	277	6	a	a	DT
cord-022290-p0l1kv6n	277	7	peptide	peptide	NN
cord-022290-p0l1kv6n	277	8	substrate	substrate	NN
cord-022290-p0l1kv6n	277	9	orients	orient	VBZ
cord-022290-p0l1kv6n	277	10	at	at	IN
cord-022290-p0l1kv6n	277	11	least	least	JJS
cord-022290-p0l1kv6n	277	12	some	some	DT
cord-022290-p0l1kv6n	277	13	of	of	IN
cord-022290-p0l1kv6n	277	14	the	the	DT
cord-022290-p0l1kv6n	277	15	peptide	peptide	JJ
cord-022290-p0l1kv6n	277	16	side	side	NN
cord-022290-p0l1kv6n	277	17	-	-	HYPH
cord-022290-p0l1kv6n	277	18	chains	chain	NNS
cord-022290-p0l1kv6n	277	19	into	into	IN
cord-022290-p0l1kv6n	277	20	specificity	specificity	NN
cord-022290-p0l1kv6n	277	21	pockets	pocket	NNS
cord-022290-p0l1kv6n	277	22	,	,	,
cord-022290-p0l1kv6n	277	23	which	which	WDT
cord-022290-p0l1kv6n	277	24	are	be	VBP
cord-022290-p0l1kv6n	277	25	formed	form	VBN
cord-022290-p0l1kv6n	277	26	by	by	IN
cord-022290-p0l1kv6n	277	27	the	the	DT
cord-022290-p0l1kv6n	277	28	surface	surface	NN
cord-022290-p0l1kv6n	277	29	of	of	IN
cord-022290-p0l1kv6n	277	30	the	the	DT
cord-022290-p0l1kv6n	277	31	enzyme	enzyme	NN
cord-022290-p0l1kv6n	277	32	.	.	.
cord-022290-p0l1kv6n	278	1	While	while	IN
cord-022290-p0l1kv6n	278	2	interactions	interaction	NNS
cord-022290-p0l1kv6n	278	3	between	between	IN
cord-022290-p0l1kv6n	278	4	the	the	DT
cord-022290-p0l1kv6n	278	5	enzyme	enzyme	NN
cord-022290-p0l1kv6n	278	6	and	and	CC
cord-022290-p0l1kv6n	278	7	the	the	DT
cord-022290-p0l1kv6n	278	8	main	main	JJ
cord-022290-p0l1kv6n	278	9	-	-	HYPH
cord-022290-p0l1kv6n	278	10	chain	chain	NN
cord-022290-p0l1kv6n	278	11	of	of	IN
cord-022290-p0l1kv6n	278	12	a	a	DT
cord-022290-p0l1kv6n	278	13	bound	bind	VBN
cord-022290-p0l1kv6n	278	14	substrate	substrate	NN
cord-022290-p0l1kv6n	278	15	contribute	contribute	VBP
cord-022290-p0l1kv6n	278	16	significantly	significantly	RB
cord-022290-p0l1kv6n	278	17	to	to	IN
cord-022290-p0l1kv6n	278	18	the	the	DT
cord-022290-p0l1kv6n	278	19	binding	binding	NN
cord-022290-p0l1kv6n	278	20	of	of	IN
cord-022290-p0l1kv6n	278	21	a	a	DT
cord-022290-p0l1kv6n	278	22	substrate	substrate	NN
cord-022290-p0l1kv6n	278	23	,	,	,
cord-022290-p0l1kv6n	278	24	most	most	JJS
cord-022290-p0l1kv6n	278	25	of	of	IN
cord-022290-p0l1kv6n	278	26	the	the	DT
cord-022290-p0l1kv6n	278	27	specificity	specificity	NN
cord-022290-p0l1kv6n	278	28	is	be	VBZ
cord-022290-p0l1kv6n	278	29	provided	provide	VBN
cord-022290-p0l1kv6n	278	30	by	by	IN
cord-022290-p0l1kv6n	278	31	the	the	DT
cord-022290-p0l1kv6n	278	32	interactions	interaction	NNS
cord-022290-p0l1kv6n	278	33	of	of	IN
cord-022290-p0l1kv6n	278	34	the	the	DT
cord-022290-p0l1kv6n	278	35	peptide	peptide	JJ
cord-022290-p0l1kv6n	278	36	side	side	NN
cord-022290-p0l1kv6n	278	37	-	-	HYPH
cord-022290-p0l1kv6n	278	38	chains	chain	NNS
cord-022290-p0l1kv6n	278	39	in	in	IN
cord-022290-p0l1kv6n	278	40	the	the	DT
cord-022290-p0l1kv6n	278	41	specificity	specificity	NN
cord-022290-p0l1kv6n	278	42	pockets	pocket	NNS
cord-022290-p0l1kv6n	278	43	of	of	IN
cord-022290-p0l1kv6n	278	44	the	the	DT
cord-022290-p0l1kv6n	278	45	enzyme	enzyme	NN
cord-022290-p0l1kv6n	278	46	(	(	-LRB-
cord-022290-p0l1kv6n	278	47	Fig	Fig	NNP
cord-022290-p0l1kv6n	278	48	.	.	NNP
cord-022290-p0l1kv6n	278	49	5	5	CD
cord-022290-p0l1kv6n	278	50	,	,	,
cord-022290-p0l1kv6n	278	51	see	see	VB
cord-022290-p0l1kv6n	278	52	color	color	NN
cord-022290-p0l1kv6n	278	53	plate	plate	NN
cord-022290-p0l1kv6n	278	54	)	)	-RRB-
cord-022290-p0l1kv6n	278	55	.	.	.
cord-022290-p0l1kv6n	279	1	The	the	DT
cord-022290-p0l1kv6n	279	2	minimum	minimum	JJ
cord-022290-p0l1kv6n	279	3	size	size	NN
cord-022290-p0l1kv6n	279	4	for	for	IN
cord-022290-p0l1kv6n	279	5	a	a	DT
cord-022290-p0l1kv6n	279	6	good	good	JJ
cord-022290-p0l1kv6n	279	7	substrate	substrate	NN
cord-022290-p0l1kv6n	279	8	of	of	IN
cord-022290-p0l1kv6n	279	9	a	a	DT
cord-022290-p0l1kv6n	279	10	3C	3c	NN
cord-022290-p0l1kv6n	279	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	279	12	is	be	VBZ
cord-022290-p0l1kv6n	279	13	a	a	DT
cord-022290-p0l1kv6n	279	14	hexapeptide	hexapeptide	NN
cord-022290-p0l1kv6n	279	15	with	with	IN
cord-022290-p0l1kv6n	279	16	the	the	DT
cord-022290-p0l1kv6n	279	17	specific	specific	JJ
cord-022290-p0l1kv6n	279	18	P4	p4	NN
cord-022290-p0l1kv6n	279	19	to	to	IN
cord-022290-p0l1kv6n	279	20	P~	p~	DT
cord-022290-p0l1kv6n	279	21	residues	residue	NNS
cord-022290-p0l1kv6n	279	22	.	.	.
cord-022290-p0l1kv6n	280	1	Sequence	sequence	NN
cord-022290-p0l1kv6n	280	2	preferences	preference	NNS
cord-022290-p0l1kv6n	280	3	for	for	IN
cord-022290-p0l1kv6n	280	4	certain	certain	JJ
cord-022290-p0l1kv6n	280	5	residues	residue	NNS
cord-022290-p0l1kv6n	280	6	that	that	WDT
cord-022290-p0l1kv6n	280	7	distinguish	distinguish	VBP
cord-022290-p0l1kv6n	280	8	the	the	DT
cord-022290-p0l1kv6n	280	9	3C	3C	NNP
cord-022290-p0l1kv6n	280	10	cleavage	cleavage	NN
cord-022290-p0l1kv6n	280	11	sites	site	NNS
cord-022290-p0l1kv6n	280	12	in	in	IN
cord-022290-p0l1kv6n	280	13	the	the	DT
cord-022290-p0l1kv6n	280	14	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	280	15	polyprotein	polyprotein	NNP
cord-022290-p0l1kv6n	280	16	can	can	MD
cord-022290-p0l1kv6n	280	17	also	also	RB
cord-022290-p0l1kv6n	280	18	be	be	VB
cord-022290-p0l1kv6n	280	19	found	find	VBN
cord-022290-p0l1kv6n	280	20	for	for	IN
cord-022290-p0l1kv6n	280	21	the	the	DT
cord-022290-p0l1kv6n	280	22	P4	P4	NNP
cord-022290-p0l1kv6n	280	23	to	to	IN
cord-022290-p0l1kv6n	280	24	P	p	NN
cord-022290-p0l1kv6n	280	25	;	;	,
cord-022290-p0l1kv6n	280	26	residues	residue	NNS
cord-022290-p0l1kv6n	280	27	Weidner	Weidner	NNP
cord-022290-p0l1kv6n	280	28	and	and	CC
cord-022290-p0l1kv6n	280	29	Dunn	Dunn	NNP
cord-022290-p0l1kv6n	280	30	,	,	,
cord-022290-p0l1kv6n	280	31	1991	1991	CD
cord-022290-p0l1kv6n	280	32	;	;	:
cord-022290-p0l1kv6n	280	33	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	280	34	,	,	,
cord-022290-p0l1kv6n	280	35	1998	1998	CD
cord-022290-p0l1kv6n	280	36	and	and	CC
cord-022290-p0l1kv6n	280	37	references	reference	NNS
cord-022290-p0l1kv6n	280	38	therein	therein	RB
cord-022290-p0l1kv6n	280	39	)	)	-RRB-
cord-022290-p0l1kv6n	280	40	.	.	.
cord-022290-p0l1kv6n	281	1	Figure	figure	NN
cord-022290-p0l1kv6n	281	2	5	5	CD
cord-022290-p0l1kv6n	281	3	shows	show	VBZ
cord-022290-p0l1kv6n	281	4	a	a	DT
cord-022290-p0l1kv6n	281	5	model	model	NN
cord-022290-p0l1kv6n	281	6	of	of	IN
cord-022290-p0l1kv6n	281	7	a	a	DT
cord-022290-p0l1kv6n	281	8	hexapeptide	hexapeptide	NN
cord-022290-p0l1kv6n	281	9	substrate	substrate	NN
cord-022290-p0l1kv6n	281	10	with	with	IN
cord-022290-p0l1kv6n	281	11	the	the	DT
cord-022290-p0l1kv6n	281	12	sequence	sequence	NN
cord-022290-p0l1kv6n	281	13	of	of	IN
cord-022290-p0l1kv6n	281	14	the	the	DT
cord-022290-p0l1kv6n	281	15	primary	primary	JJ
cord-022290-p0l1kv6n	281	16	cleavage	cleavage	NN
cord-022290-p0l1kv6n	281	17	site	site	NN
cord-022290-p0l1kv6n	281	18	of	of	IN
cord-022290-p0l1kv6n	281	19	the	the	DT
cord-022290-p0l1kv6n	281	20	HAV	HAV	NNP
cord-022290-p0l1kv6n	281	21	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	281	22	in	in	IN
cord-022290-p0l1kv6n	281	23	the	the	DT
cord-022290-p0l1kv6n	281	24	active	active	JJ
cord-022290-p0l1kv6n	281	25	site	site	NN
cord-022290-p0l1kv6n	281	26	of	of	IN
cord-022290-p0l1kv6n	281	27	HAV	HAV	NNP
cord-022290-p0l1kv6n	281	28	3C.	3c.	CD
cord-022290-p0l1kv6n	281	29	With	with	IN
cord-022290-p0l1kv6n	281	30	the	the	DT
cord-022290-p0l1kv6n	281	31	exception	exception	NN
cord-022290-p0l1kv6n	281	32	of	of	IN
cord-022290-p0l1kv6n	281	33	the	the	DT
cord-022290-p0l1kv6n	281	34	two	two	CD
cord-022290-p0l1kv6n	281	35	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	281	36	bonds	bond	NNS
cord-022290-p0l1kv6n	281	37	that	that	WDT
cord-022290-p0l1kv6n	281	38	the	the	DT
cord-022290-p0l1kv6n	281	39	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	281	40	of	of	IN
cord-022290-p0l1kv6n	281	41	the	the	DT
cord-022290-p0l1kv6n	281	42	scissile	scissile	NNP
cord-022290-p0l1kv6n	281	43	peptide	peptide	NNP
cord-022290-p0l1kv6n	281	44	bond	bond	NN
cord-022290-p0l1kv6n	281	45	makes	make	VBZ
cord-022290-p0l1kv6n	281	46	in	in	IN
cord-022290-p0l1kv6n	281	47	the	the	DT
cord-022290-p0l1kv6n	281	48	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	281	49	hole	hole	NN
cord-022290-p0l1kv6n	281	50	,	,	,
cord-022290-p0l1kv6n	281	51	the	the	DT
cord-022290-p0l1kv6n	281	52	main	main	JJ
cord-022290-p0l1kv6n	281	53	-	-	HYPH
cord-022290-p0l1kv6n	281	54	chain	chain	NN
cord-022290-p0l1kv6n	281	55	interactions	interaction	NNS
cord-022290-p0l1kv6n	281	56	between	between	IN
cord-022290-p0l1kv6n	281	57	the	the	DT
cord-022290-p0l1kv6n	281	58	HAV	HAV	NNP
cord-022290-p0l1kv6n	281	59	3C	3C	NNP
cord-022290-p0l1kv6n	281	60	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	281	61	and	and	CC
cord-022290-p0l1kv6n	281	62	the	the	DT
cord-022290-p0l1kv6n	281	63	bound	bind	VBN
cord-022290-p0l1kv6n	281	64	peptide	peptide	NN
cord-022290-p0l1kv6n	281	65	are	be	VBP
cord-022290-p0l1kv6n	281	66	/	/	SYM
cord-022290-p0l1kv6n	281	67	t	t	NN
cord-022290-p0l1kv6n	281	68	-	-	HYPH
cord-022290-p0l1kv6n	281	69	sheet	sheet	NN
cord-022290-p0l1kv6n	281	70	interactions	interaction	NNS
cord-022290-p0l1kv6n	281	71	.	.	.
cord-022290-p0l1kv6n	282	1	In	in	IN
cord-022290-p0l1kv6n	282	2	HAV	HAV	NNP
cord-022290-p0l1kv6n	282	3	3C	3c	NN
cord-022290-p0l1kv6n	282	4	the	the	DT
cord-022290-p0l1kv6n	282	5	substrate	substrate	NN
cord-022290-p0l1kv6n	282	6	residues	residue	NNS
cord-022290-p0l1kv6n	282	7	from	from	IN
cord-022290-p0l1kv6n	282	8	P5	p5	NN
cord-022290-p0l1kv6n	282	9	to	to	IN
cord-022290-p0l1kv6n	282	10	P2	P2	NNP
cord-022290-p0l1kv6n	282	11	form	form	VB
cord-022290-p0l1kv6n	282	12	an	an	DT
cord-022290-p0l1kv6n	282	13	antiparallel/3-sheet	antiparallel/3-sheet	CD
cord-022290-p0l1kv6n	282	14	with/3-strand	with/3-strand	CD
cord-022290-p0l1kv6n	282	15	eII	eii	NN
cord-022290-p0l1kv6n	282	16	.	.	.
cord-022290-p0l1kv6n	283	1	This	this	DT
cord-022290-p0l1kv6n	283	2	form	form	NN
cord-022290-p0l1kv6n	283	3	of	of	IN
cord-022290-p0l1kv6n	283	4	substrate	substrate	NN
cord-022290-p0l1kv6n	283	5	binding	binding	NN
cord-022290-p0l1kv6n	283	6	is	be	VBZ
cord-022290-p0l1kv6n	283	7	common	common	JJ
cord-022290-p0l1kv6n	283	8	to	to	IN
cord-022290-p0l1kv6n	283	9	all	all	DT
cord-022290-p0l1kv6n	283	10	chymotrypsin	chymotrypsin	VB
cord-022290-p0l1kv6n	283	11	-	-	HYPH
cord-022290-p0l1kv6n	283	12	like	like	JJ
cord-022290-p0l1kv6n	283	13	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	283	14	.	.	.
cord-022290-p0l1kv6n	284	1	In	in	IN
cord-022290-p0l1kv6n	284	2	HAV	HAV	NNP
cord-022290-p0l1kv6n	284	3	3C	3c	NN
cord-022290-p0l1kv6n	284	4	there	there	EX
cord-022290-p0l1kv6n	284	5	is	be	VBZ
cord-022290-p0l1kv6n	284	6	also	also	RB
cord-022290-p0l1kv6n	284	7	a	a	DT
cord-022290-p0l1kv6n	284	8	parallel	parallel	JJ
cord-022290-p0l1kv6n	284	9	/	/	SYM
cord-022290-p0l1kv6n	284	10	t	t	NN
cord-022290-p0l1kv6n	284	11	-	-	HYPH
cord-022290-p0l1kv6n	284	12	sheet	sheet	NN
cord-022290-p0l1kv6n	284	13	interaction	interaction	NN
cord-022290-p0l1kv6n	284	14	between	between	IN
cord-022290-p0l1kv6n	284	15	the	the	DT
cord-022290-p0l1kv6n	284	16	P4	P4	NNP
cord-022290-p0l1kv6n	284	17	to	to	IN
cord-022290-p0l1kv6n	284	18	P2	p2	NN
cord-022290-p0l1kv6n	284	19	residues	residue	NNS
cord-022290-p0l1kv6n	284	20	of	of	IN
cord-022290-p0l1kv6n	284	21	the	the	DT
cord-022290-p0l1kv6n	284	22	substrate	substrate	NN
cord-022290-p0l1kv6n	284	23	and	and	CC
cord-022290-p0l1kv6n	284	24	enzyme	enzyme	NN
cord-022290-p0l1kv6n	284	25	residue	residue	NN
cord-022290-p0l1kv6n	284	26	from	from	IN
cord-022290-p0l1kv6n	284	27	the	the	DT
cord-022290-p0l1kv6n	284	28	extension	extension	NN
cord-022290-p0l1kv6n	284	29	of	of	IN
cord-022290-p0l1kv6n	284	30	/	/	SYM
cord-022290-p0l1kv6n	284	31	t	t	NN
cord-022290-p0l1kv6n	284	32	-	-	HYPH
cord-022290-p0l1kv6n	284	33	strand	strand	NN
cord-022290-p0l1kv6n	284	34	bII	bII	NNP
cord-022290-p0l1kv6n	284	35	.	.	.
cord-022290-p0l1kv6n	285	1	This	this	DT
cord-022290-p0l1kv6n	285	2	extension	extension	NN
cord-022290-p0l1kv6n	285	3	is	be	VBZ
cord-022290-p0l1kv6n	285	4	not	not	RB
cord-022290-p0l1kv6n	285	5	present	present	JJ
cord-022290-p0l1kv6n	285	6	in	in	IN
cord-022290-p0l1kv6n	285	7	the	the	DT
cord-022290-p0l1kv6n	285	8	smaller	small	JJR
cord-022290-p0l1kv6n	285	9	enteroviral	enteroviral	JJ
cord-022290-p0l1kv6n	285	10	3C.	3c.	CD
cord-022290-p0l1kv6n	285	11	Third	Third	NNP
cord-022290-p0l1kv6n	285	12	,	,	,
cord-022290-p0l1kv6n	285	13	the	the	DT
cord-022290-p0l1kv6n	285	14	P'I	P'I	NNP
cord-022290-p0l1kv6n	285	15	and	and	CC
cord-022290-p0l1kv6n	285	16	P2	P2	NNP
cord-022290-p0l1kv6n	285	17	residues	residue	NNS
cord-022290-p0l1kv6n	285	18	of	of	IN
cord-022290-p0l1kv6n	285	19	the	the	DT
cord-022290-p0l1kv6n	285	20	substrate	substrate	NN
cord-022290-p0l1kv6n	285	21	of	of	IN
cord-022290-p0l1kv6n	285	22	HAV	HAV	NNP
cord-022290-p0l1kv6n	285	23	3C	3c	NN
cord-022290-p0l1kv6n	285	24	form	form	VB
cord-022290-p0l1kv6n	285	25	an	an	DT
cord-022290-p0l1kv6n	285	26	antiparallel	antiparallel	NN
cord-022290-p0l1kv6n	285	27	/	/	SYM
cord-022290-p0l1kv6n	285	28	t	t	NN
cord-022290-p0l1kv6n	285	29	-	-	HYPH
cord-022290-p0l1kv6n	285	30	interaction	interaction	NN
cord-022290-p0l1kv6n	285	31	with	with	IN
cord-022290-p0l1kv6n	285	32	the	the	DT
cord-022290-p0l1kv6n	285	33	residues	residue	NNS
cord-022290-p0l1kv6n	285	34	of	of	IN
cord-022290-p0l1kv6n	285	35	the	the	DT
cord-022290-p0l1kv6n	285	36	enzyme	enzyme	NN
cord-022290-p0l1kv6n	285	37	,	,	,
cord-022290-p0l1kv6n	285	38	which	which	WDT
cord-022290-p0l1kv6n	285	39	form	form	VBP
cord-022290-p0l1kv6n	285	40	the/3-bulge	the/3-bulge	:
cord-022290-p0l1kv6n	285	41	in	in	IN
cord-022290-p0l1kv6n	285	42	strand	strand	NN
cord-022290-p0l1kv6n	285	43	bI	bi	NN
cord-022290-p0l1kv6n	285	44	of	of	IN
cord-022290-p0l1kv6n	285	45	the	the	DT
cord-022290-p0l1kv6n	285	46	enzyme	enzyme	NN
cord-022290-p0l1kv6n	285	47	.	.	.
cord-022290-p0l1kv6n	286	1	The	the	DT
cord-022290-p0l1kv6n	286	2	conformation	conformation	NN
cord-022290-p0l1kv6n	286	3	of	of	IN
cord-022290-p0l1kv6n	286	4	fl	fl	JJ
cord-022290-p0l1kv6n	286	5	-	-	HYPH
cord-022290-p0l1kv6n	286	6	strand	strand	NN
cord-022290-p0l1kv6n	286	7	bI	bI	NNP
cord-022290-p0l1kv6n	286	8	is	be	VBZ
cord-022290-p0l1kv6n	286	9	different	different	JJ
cord-022290-p0l1kv6n	286	10	in	in	IN
cord-022290-p0l1kv6n	286	11	polio	polio	NNP
cord-022290-p0l1kv6n	286	12	3C	3C	NNP
cord-022290-p0l1kv6n	286	13	and	and	CC
cord-022290-p0l1kv6n	286	14	presumably	presumably	RB
cord-022290-p0l1kv6n	286	15	forces	force	VBZ
cord-022290-p0l1kv6n	286	16	a	a	DT
cord-022290-p0l1kv6n	286	17	different	different	JJ
cord-022290-p0l1kv6n	286	18	mainchain	mainchain	NN
cord-022290-p0l1kv6n	286	19	conformation	conformation	NN
cord-022290-p0l1kv6n	286	20	on	on	IN
cord-022290-p0l1kv6n	286	21	the	the	DT
cord-022290-p0l1kv6n	286	22	substrate	substrate	NN
cord-022290-p0l1kv6n	286	23	.	.	.
cord-022290-p0l1kv6n	287	1	This	this	DT
cord-022290-p0l1kv6n	287	2	could	could	MD
cord-022290-p0l1kv6n	287	3	explain	explain	VB
cord-022290-p0l1kv6n	287	4	the	the	DT
cord-022290-p0l1kv6n	287	5	unique	unique	JJ
cord-022290-p0l1kv6n	287	6	preference	preference	NN
cord-022290-p0l1kv6n	287	7	of	of	IN
cord-022290-p0l1kv6n	287	8	polio	polio	NNP
cord-022290-p0l1kv6n	287	9	3C	3C	NNP
cord-022290-p0l1kv6n	287	10	for	for	IN
cord-022290-p0l1kv6n	287	11	a	a	DT
cord-022290-p0l1kv6n	287	12	P'I	p'i	JJ
cord-022290-p0l1kv6n	287	13	glycine	glycine	NN
cord-022290-p0l1kv6n	287	14	residue	residue	NN
cord-022290-p0l1kv6n	287	15	.	.	.
cord-022290-p0l1kv6n	288	1	All	all	DT
cord-022290-p0l1kv6n	288	2	3C	3C	NNP
cord-022290-p0l1kv6n	288	3	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	288	4	share	share	VBP
cord-022290-p0l1kv6n	288	5	the	the	DT
cord-022290-p0l1kv6n	288	6	preference	preference	NN
cord-022290-p0l1kv6n	288	7	for	for	IN
cord-022290-p0l1kv6n	288	8	a	a	DT
cord-022290-p0l1kv6n	288	9	glutamine	glutamine	NN
cord-022290-p0l1kv6n	288	10	residue	residue	NN
cord-022290-p0l1kv6n	288	11	in	in	IN
cord-022290-p0l1kv6n	288	12	the	the	DT
cord-022290-p0l1kv6n	288	13	P1	P1	NNP
cord-022290-p0l1kv6n	288	14	position	position	NN
cord-022290-p0l1kv6n	288	15	of	of	IN
cord-022290-p0l1kv6n	288	16	a	a	DT
cord-022290-p0l1kv6n	288	17	substrate	substrate	NN
cord-022290-p0l1kv6n	288	18	.	.	.
cord-022290-p0l1kv6n	289	1	Sequence	sequence	NN
cord-022290-p0l1kv6n	289	2	preferences	preference	NNS
cord-022290-p0l1kv6n	289	3	for	for	IN
cord-022290-p0l1kv6n	289	4	the	the	DT
cord-022290-p0l1kv6n	289	5	other	other	JJ
cord-022290-p0l1kv6n	289	6	residues	residue	NNS
cord-022290-p0l1kv6n	289	7	of	of	IN
cord-022290-p0l1kv6n	289	8	a	a	DT
cord-022290-p0l1kv6n	289	9	substrate	substrate	NN
cord-022290-p0l1kv6n	289	10	from	from	IN
cord-022290-p0l1kv6n	289	11	P4	P4	NNP
cord-022290-p0l1kv6n	289	12	to	to	IN
cord-022290-p0l1kv6n	289	13	P~	P~	NNP
cord-022290-p0l1kv6n	289	14	'	'	''
cord-022290-p0l1kv6n	289	15	differ	differ	VB
cord-022290-p0l1kv6n	289	16	among	among	IN
cord-022290-p0l1kv6n	289	17	the	the	DT
cord-022290-p0l1kv6n	289	18	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	289	19	from	from	IN
cord-022290-p0l1kv6n	289	20	the	the	DT
cord-022290-p0l1kv6n	289	21	different	different	JJ
cord-022290-p0l1kv6n	289	22	genera	genus	NNS
cord-022290-p0l1kv6n	289	23	.	.	.
cord-022290-p0l1kv6n	290	1	The	the	DT
cord-022290-p0l1kv6n	290	2	major	major	JJ
cord-022290-p0l1kv6n	290	3	determinant	determinant	NN
cord-022290-p0l1kv6n	290	4	of	of	IN
cord-022290-p0l1kv6n	290	5	the	the	DT
cord-022290-p0l1kv6n	290	6	primary	primary	JJ
cord-022290-p0l1kv6n	290	7	specificity	specificity	NN
cord-022290-p0l1kv6n	290	8	is	be	VBZ
cord-022290-p0l1kv6n	290	9	a	a	DT
cord-022290-p0l1kv6n	290	10	conserved	conserve	VBN
cord-022290-p0l1kv6n	290	11	histidine	histidine	NN
cord-022290-p0l1kv6n	290	12	residue	residue	NN
cord-022290-p0l1kv6n	290	13	which	which	WDT
cord-022290-p0l1kv6n	290	14	is	be	VBZ
cord-022290-p0l1kv6n	290	15	positioned	position	VBN
cord-022290-p0l1kv6n	290	16	inside	inside	IN
cord-022290-p0l1kv6n	290	17	the	the	DT
cord-022290-p0l1kv6n	290	18	S1	s1	NN
cord-022290-p0l1kv6n	290	19	pocket	pocket	NN
cord-022290-p0l1kv6n	290	20	of	of	IN
cord-022290-p0l1kv6n	290	21	the	the	DT
cord-022290-p0l1kv6n	290	22	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	290	23	(	(	-LRB-
cord-022290-p0l1kv6n	290	24	Fig	Fig	NNP
cord-022290-p0l1kv6n	290	25	.	.	NNP
cord-022290-p0l1kv6n	290	26	4	4	CD
cord-022290-p0l1kv6n	290	27	)	)	-RRB-
cord-022290-p0l1kv6n	290	28	.	.	.
cord-022290-p0l1kv6n	291	1	This	this	DT
cord-022290-p0l1kv6n	291	2	histidine	histidine	NN
cord-022290-p0l1kv6n	291	3	residue	residue	NN
cord-022290-p0l1kv6n	291	4	(	(	-LRB-
cord-022290-p0l1kv6n	291	5	191	191	CD
cord-022290-p0l1kv6n	291	6	in	in	IN
cord-022290-p0l1kv6n	291	7	HAV	HAV	NNP
cord-022290-p0l1kv6n	291	8	and	and	CC
cord-022290-p0l1kv6n	291	9	161	161	CD
cord-022290-p0l1kv6n	291	10	in	in	IN
cord-022290-p0l1kv6n	291	11	hnPV	hnPV	NNP
cord-022290-p0l1kv6n	291	12	)	)	-RRB-
cord-022290-p0l1kv6n	291	13	is	be	VBZ
cord-022290-p0l1kv6n	291	14	conserved	conserve	VBN
cord-022290-p0l1kv6n	291	15	throughout	throughout	IN
cord-022290-p0l1kv6n	291	16	the	the	DT
cord-022290-p0l1kv6n	291	17	3C	3C	NNP
cord-022290-p0l1kv6n	291	18	genes	gene	NNS
cord-022290-p0l1kv6n	291	19	of	of	IN
cord-022290-p0l1kv6n	291	20	all	all	DT
cord-022290-p0l1kv6n	291	21	Picornaviruses	Picornaviruses	NNP
cord-022290-p0l1kv6n	291	22	.	.	.
cord-022290-p0l1kv6n	292	1	Models	model	NNS
cord-022290-p0l1kv6n	292	2	of	of	IN
cord-022290-p0l1kv6n	292	3	substrates	substrate	NNS
cord-022290-p0l1kv6n	292	4	bound	bind	VBN
cord-022290-p0l1kv6n	292	5	to	to	IN
cord-022290-p0l1kv6n	292	6	3C	3C	NNP
cord-022290-p0l1kv6n	292	7	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	292	8	agree	agree	VBP
cord-022290-p0l1kv6n	292	9	that	that	IN
cord-022290-p0l1kv6n	292	10	this	this	DT
cord-022290-p0l1kv6n	292	11	histidine	histidine	NN
cord-022290-p0l1kv6n	292	12	residue	residue	NN
cord-022290-p0l1kv6n	292	13	donates	donate	VBZ
cord-022290-p0l1kv6n	292	14	a	a	DT
cord-022290-p0l1kv6n	292	15	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	292	16	bond	bond	NN
cord-022290-p0l1kv6n	292	17	to	to	IN
cord-022290-p0l1kv6n	292	18	the	the	DT
cord-022290-p0l1kv6n	292	19	carbonyl	carbonyl	NN
cord-022290-p0l1kv6n	292	20	oxygen	oxygen	NN
cord-022290-p0l1kv6n	292	21	atom	atom	NN
cord-022290-p0l1kv6n	292	22	of	of	IN
cord-022290-p0l1kv6n	292	23	the	the	DT
cord-022290-p0l1kv6n	292	24	side	side	NN
cord-022290-p0l1kv6n	292	25	-	-	HYPH
cord-022290-p0l1kv6n	292	26	chain	chain	NN
cord-022290-p0l1kv6n	292	27	of	of	IN
cord-022290-p0l1kv6n	292	28	a	a	DT
cord-022290-p0l1kv6n	292	29	glutamine	glutamine	NN
cord-022290-p0l1kv6n	292	30	residue	residue	NN
cord-022290-p0l1kv6n	292	31	in	in	IN
cord-022290-p0l1kv6n	292	32	the	the	DT
cord-022290-p0l1kv6n	292	33	$	$	$
cord-022290-p0l1kv6n	292	34	1	1	CD
cord-022290-p0l1kv6n	292	35	pocket	pocket	NN
cord-022290-p0l1kv6n	292	36	.	.	.
cord-022290-p0l1kv6n	293	1	The	the	DT
cord-022290-p0l1kv6n	293	2	environment	environment	NN
cord-022290-p0l1kv6n	293	3	of	of	IN
cord-022290-p0l1kv6n	293	4	this	this	DT
cord-022290-p0l1kv6n	293	5	histidine	histidine	NN
cord-022290-p0l1kv6n	293	6	,	,	,
cord-022290-p0l1kv6n	293	7	which	which	WDT
cord-022290-p0l1kv6n	293	8	must	must	MD
cord-022290-p0l1kv6n	293	9	contribute	contribute	VB
cord-022290-p0l1kv6n	293	10	to	to	IN
cord-022290-p0l1kv6n	293	11	the	the	DT
cord-022290-p0l1kv6n	293	12	specific	specific	JJ
cord-022290-p0l1kv6n	293	13	distinction	distinction	NN
cord-022290-p0l1kv6n	293	14	between	between	IN
cord-022290-p0l1kv6n	293	15	glutamine	glutamine	NN
cord-022290-p0l1kv6n	293	16	and	and	CC
cord-022290-p0l1kv6n	293	17	glutamate	glutamate	NN
cord-022290-p0l1kv6n	293	18	,	,	,
cord-022290-p0l1kv6n	293	19	is	be	VBZ
cord-022290-p0l1kv6n	293	20	,	,	,
cord-022290-p0l1kv6n	293	21	however	however	RB
cord-022290-p0l1kv6n	293	22	,	,	,
cord-022290-p0l1kv6n	293	23	different	different	JJ
cord-022290-p0l1kv6n	293	24	in	in	IN
cord-022290-p0l1kv6n	293	25	the	the	DT
cord-022290-p0l1kv6n	293	26	crystal	crystal	NN
cord-022290-p0l1kv6n	293	27	structures	structure	NNS
cord-022290-p0l1kv6n	293	28	of	of	IN
cord-022290-p0l1kv6n	293	29	HAV	HAV	NNP
cord-022290-p0l1kv6n	293	30	3C	3C	NNP
cord-022290-p0l1kv6n	293	31	and	and	CC
cord-022290-p0l1kv6n	293	32	PV	PV	NNP
cord-022290-p0l1kv6n	293	33	3C.	3c.	CD
cord-022290-p0l1kv6n	294	1	In	in	IN
cord-022290-p0l1kv6n	294	2	HAV	HAV	NNP
cord-022290-p0l1kv6n	294	3	3C	3C	NNP
cord-022290-p0l1kv6n	294	4	His191	his191	NN
cord-022290-p0l1kv6n	294	5	interacts	interact	VBZ
cord-022290-p0l1kv6n	294	6	,	,	,
cord-022290-p0l1kv6n	294	7	via	via	IN
cord-022290-p0l1kv6n	294	8	buried	bury	VBN
cord-022290-p0l1kv6n	294	9	water	water	NN
cord-022290-p0l1kv6n	294	10	,	,	,
cord-022290-p0l1kv6n	294	11	with	with	IN
cord-022290-p0l1kv6n	294	12	the	the	DT
cord-022290-p0l1kv6n	294	13	side	side	NN
cord-022290-p0l1kv6n	294	14	-	-	HYPH
cord-022290-p0l1kv6n	294	15	chain	chain	NN
cord-022290-p0l1kv6n	294	16	of	of	IN
cord-022290-p0l1kv6n	294	17	Glu	Glu	NNP
cord-022290-p0l1kv6n	294	18	132	132	CD
cord-022290-p0l1kv6n	294	19	.	.	.
cord-022290-p0l1kv6n	295	1	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	295	2	et	et	NNP
cord-022290-p0l1kv6n	295	3	al	al	NNP
cord-022290-p0l1kv6n	295	4	.	.	.
cord-022290-p0l1kv6n	296	1	(	(	-LRB-
cord-022290-p0l1kv6n	296	2	1997	1997	CD
cord-022290-p0l1kv6n	296	3	)	)	-RRB-
cord-022290-p0l1kv6n	296	4	suggest	suggest	VBP
cord-022290-p0l1kv6n	296	5	that	that	IN
cord-022290-p0l1kv6n	296	6	the	the	DT
cord-022290-p0l1kv6n	296	7	deprotonation	deprotonation	NN
cord-022290-p0l1kv6n	296	8	of	of	IN
cord-022290-p0l1kv6n	296	9	this	this	DT
cord-022290-p0l1kv6n	296	10	Glu	Glu	NNP
cord-022290-p0l1kv6n	296	11	132	132	CD
cord-022290-p0l1kv6n	296	12	,	,	,
cord-022290-p0l1kv6n	296	13	which	which	WDT
cord-022290-p0l1kv6n	296	14	is	be	VBZ
cord-022290-p0l1kv6n	296	15	buried	bury	VBN
cord-022290-p0l1kv6n	296	16	in	in	IN
cord-022290-p0l1kv6n	296	17	the	the	DT
cord-022290-p0l1kv6n	296	18	interior	interior	NN
cord-022290-p0l1kv6n	296	19	of	of	IN
cord-022290-p0l1kv6n	296	20	the	the	DT
cord-022290-p0l1kv6n	296	21	C	C	NNP
cord-022290-p0l1kv6n	296	22	-	-	HYPH
cord-022290-p0l1kv6n	296	23	terminal	terminal	NN
cord-022290-p0l1kv6n	296	24	domain	domain	NN
cord-022290-p0l1kv6n	296	25	,	,	,
cord-022290-p0l1kv6n	296	26	would	would	MD
cord-022290-p0l1kv6n	296	27	be	be	VB
cord-022290-p0l1kv6n	296	28	energetically	energetically	RB
cord-022290-p0l1kv6n	296	29	expensive	expensive	JJ
cord-022290-p0l1kv6n	296	30	and	and	CC
cord-022290-p0l1kv6n	296	31	unfavorable	unfavorable	JJ
cord-022290-p0l1kv6n	296	32	.	.	.
cord-022290-p0l1kv6n	297	1	Because	because	IN
cord-022290-p0l1kv6n	297	2	the	the	DT
cord-022290-p0l1kv6n	297	3	two	two	CD
cord-022290-p0l1kv6n	297	4	residues	residue	NNS
cord-022290-p0l1kv6n	297	5	interact	interact	VBP
cord-022290-p0l1kv6n	297	6	,	,	,
cord-022290-p0l1kv6n	297	7	the	the	DT
cord-022290-p0l1kv6n	297	8	protonation	protonation	NN
cord-022290-p0l1kv6n	297	9	of	of	IN
cord-022290-p0l1kv6n	297	10	His191	his191	DT
cord-022290-p0l1kv6n	297	11	would	would	MD
cord-022290-p0l1kv6n	297	12	also	also	RB
cord-022290-p0l1kv6n	297	13	be	be	VB
cord-022290-p0l1kv6n	297	14	unfavorable	unfavorable	JJ
cord-022290-p0l1kv6n	297	15	.	.	.
cord-022290-p0l1kv6n	298	1	In	in	IN
cord-022290-p0l1kv6n	298	2	the	the	DT
cord-022290-p0l1kv6n	298	3	entero	entero	NNP
cord-022290-p0l1kv6n	298	4	-	-	HYPH
cord-022290-p0l1kv6n	298	5	and	and	CC
cord-022290-p0l1kv6n	298	6	rhinoviral	rhinoviral	NNP
cord-022290-p0l1kv6n	298	7	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	298	8	a	a	DT
cord-022290-p0l1kv6n	298	9	buried	bury	VBN
cord-022290-p0l1kv6n	298	10	tyrosine	tyrosine	NN
cord-022290-p0l1kv6n	298	11	residue	residue	NN
cord-022290-p0l1kv6n	298	12	performs	perform	VBZ
cord-022290-p0l1kv6n	298	13	a	a	DT
cord-022290-p0l1kv6n	298	14	similar	similar	JJ
cord-022290-p0l1kv6n	298	15	function	function	NN
cord-022290-p0l1kv6n	298	16	.	.	.
cord-022290-p0l1kv6n	299	1	Comparison	comparison	NN
cord-022290-p0l1kv6n	299	2	of	of	IN
cord-022290-p0l1kv6n	299	3	the	the	DT
cord-022290-p0l1kv6n	299	4	sequences	sequence	NNS
cord-022290-p0l1kv6n	299	5	of	of	IN
cord-022290-p0l1kv6n	299	6	the	the	DT
cord-022290-p0l1kv6n	299	7	natural	natural	JJ
cord-022290-p0l1kv6n	299	8	cleavage	cleavage	NN
cord-022290-p0l1kv6n	299	9	sites	site	NNS
cord-022290-p0l1kv6n	299	10	of	of	IN
cord-022290-p0l1kv6n	299	11	the	the	DT
cord-022290-p0l1kv6n	299	12	HAV	HAV	NNP
cord-022290-p0l1kv6n	299	13	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	299	14	reveals	reveal	VBZ
cord-022290-p0l1kv6n	299	15	distinct	distinct	JJ
cord-022290-p0l1kv6n	299	16	sequence	sequence	NN
cord-022290-p0l1kv6n	299	17	preferences	preference	NNS
cord-022290-p0l1kv6n	299	18	for	for	IN
cord-022290-p0l1kv6n	299	19	the	the	DT
cord-022290-p0l1kv6n	299	20	residues	residue	NNS
cord-022290-p0l1kv6n	299	21	in	in	IN
cord-022290-p0l1kv6n	299	22	the	the	DT
cord-022290-p0l1kv6n	299	23	P4	P4	NNP
cord-022290-p0l1kv6n	299	24	,	,	,
cord-022290-p0l1kv6n	299	25	P2	P2	NNP
cord-022290-p0l1kv6n	299	26	,	,	,
cord-022290-p0l1kv6n	299	27	and	and	CC
cord-022290-p0l1kv6n	299	28	Px	Px	NNP
cord-022290-p0l1kv6n	299	29	position	position	NN
cord-022290-p0l1kv6n	299	30	of	of	IN
cord-022290-p0l1kv6n	299	31	a	a	DT
cord-022290-p0l1kv6n	299	32	3C	3c	NN
cord-022290-p0l1kv6n	299	33	substrate	substrate	NN
cord-022290-p0l1kv6n	299	34	(	(	-LRB-
cord-022290-p0l1kv6n	299	35	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	299	36	,	,	,
cord-022290-p0l1kv6n	299	37	1998	1998	CD
cord-022290-p0l1kv6n	299	38	)	)	-RRB-
cord-022290-p0l1kv6n	299	39	.	.	.
cord-022290-p0l1kv6n	300	1	All	all	DT
cord-022290-p0l1kv6n	300	2	natural	natural	JJ
cord-022290-p0l1kv6n	300	3	cleavage	cleavage	NN
cord-022290-p0l1kv6n	300	4	sites	site	NNS
cord-022290-p0l1kv6n	300	5	in	in	IN
cord-022290-p0l1kv6n	300	6	the	the	DT
cord-022290-p0l1kv6n	300	7	HAV	HAV	NNP
cord-022290-p0l1kv6n	300	8	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	300	9	have	have	VBP
cord-022290-p0l1kv6n	300	10	large	large	JJ
cord-022290-p0l1kv6n	300	11	hydrophobic	hydrophobic	JJ
cord-022290-p0l1kv6n	300	12	residues	residue	NNS
cord-022290-p0l1kv6n	300	13	(	(	-LRB-
cord-022290-p0l1kv6n	300	14	preferably	preferably	RB
cord-022290-p0l1kv6n	300	15	Leu	Leu	NNP
cord-022290-p0l1kv6n	300	16	or	or	CC
cord-022290-p0l1kv6n	300	17	Ile	Ile	NNP
cord-022290-p0l1kv6n	300	18	)	)	-RRB-
cord-022290-p0l1kv6n	300	19	in	in	IN
cord-022290-p0l1kv6n	300	20	P4	p4	NN
cord-022290-p0l1kv6n	300	21	,	,	,
cord-022290-p0l1kv6n	300	22	serine	serine	NN
cord-022290-p0l1kv6n	300	23	or	or	CC
cord-022290-p0l1kv6n	300	24	threonine	threonine	NN
cord-022290-p0l1kv6n	300	25	in	in	IN
cord-022290-p0l1kv6n	300	26	P2	P2	NNP
cord-022290-p0l1kv6n	300	27	,	,	,
cord-022290-p0l1kv6n	300	28	and	and	CC
cord-022290-p0l1kv6n	300	29	glutamine	glutamine	NN
cord-022290-p0l1kv6n	300	30	in	in	IN
cord-022290-p0l1kv6n	300	31	P1	P1	NNP
cord-022290-p0l1kv6n	300	32	.	.	.
cord-022290-p0l1kv6n	301	1	The	the	DT
cord-022290-p0l1kv6n	301	2	3C	3c	NN
cord-022290-p0l1kv6n	301	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	301	4	from	from	IN
cord-022290-p0l1kv6n	301	5	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	301	6	has	have	VBZ
cord-022290-p0l1kv6n	301	7	a	a	DT
cord-022290-p0l1kv6n	301	8	sequence	sequence	NN
cord-022290-p0l1kv6n	301	9	preference	preference	NN
cord-022290-p0l1kv6n	301	10	for	for	IN
cord-022290-p0l1kv6n	301	11	a	a	DT
cord-022290-p0l1kv6n	301	12	small	small	JJ
cord-022290-p0l1kv6n	301	13	,	,	,
cord-022290-p0l1kv6n	301	14	hydrophobic	hydrophobic	JJ
cord-022290-p0l1kv6n	301	15	residue	residue	NN
cord-022290-p0l1kv6n	301	16	in	in	IN
cord-022290-p0l1kv6n	301	17	P4	P4	NNP
cord-022290-p0l1kv6n	301	18	,	,	,
cord-022290-p0l1kv6n	301	19	glutamine	glutamine	NN
cord-022290-p0l1kv6n	301	20	in	in	IN
cord-022290-p0l1kv6n	301	21	Px	Px	NNP
cord-022290-p0l1kv6n	301	22	,	,	,
cord-022290-p0l1kv6n	301	23	and	and	CC
cord-022290-p0l1kv6n	301	24	glycine	glycine	NN
cord-022290-p0l1kv6n	301	25	in	in	IN
cord-022290-p0l1kv6n	301	26	the	the	DT
cord-022290-p0l1kv6n	301	27	P'I	p'i	JJ
cord-022290-p0l1kv6n	301	28	position	position	NN
cord-022290-p0l1kv6n	301	29	of	of	IN
cord-022290-p0l1kv6n	301	30	a	a	DT
cord-022290-p0l1kv6n	301	31	peptide	peptide	NN
cord-022290-p0l1kv6n	301	32	substrate	substrate	NN
cord-022290-p0l1kv6n	301	33	.	.	.
cord-022290-p0l1kv6n	302	1	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	302	2	et	et	NNP
cord-022290-p0l1kv6n	302	3	al	al	NNP
cord-022290-p0l1kv6n	302	4	.	.	.
cord-022290-p0l1kv6n	303	1	(	(	-LRB-
cord-022290-p0l1kv6n	303	2	1997	1997	CD
cord-022290-p0l1kv6n	303	3	)	)	-RRB-
cord-022290-p0l1kv6n	303	4	suggest	suggest	VBP
cord-022290-p0l1kv6n	303	5	that	that	IN
cord-022290-p0l1kv6n	303	6	His145	his145	DT
cord-022290-p0l1kv6n	303	7	in	in	IN
cord-022290-p0l1kv6n	303	8	HAV	HAV	NNP
cord-022290-p0l1kv6n	303	9	3C	3c	NN
cord-022290-p0l1kv6n	303	10	can	can	MD
cord-022290-p0l1kv6n	303	11	form	form	VB
cord-022290-p0l1kv6n	303	12	a	a	DT
cord-022290-p0l1kv6n	303	13	hydrogen	hydrogen	NN
cord-022290-p0l1kv6n	303	14	bond	bond	NN
cord-022290-p0l1kv6n	303	15	to	to	IN
cord-022290-p0l1kv6n	303	16	a	a	DT
cord-022290-p0l1kv6n	303	17	serine	serine	NN
cord-022290-p0l1kv6n	303	18	or	or	CC
cord-022290-p0l1kv6n	303	19	threonine	threonine	NN
cord-022290-p0l1kv6n	303	20	residue	residue	NN
cord-022290-p0l1kv6n	303	21	in	in	IN
cord-022290-p0l1kv6n	303	22	P2	P2	NNP
cord-022290-p0l1kv6n	303	23	and	and	CC
cord-022290-p0l1kv6n	303	24	is	be	VBZ
cord-022290-p0l1kv6n	303	25	therefore	therefore	RB
cord-022290-p0l1kv6n	303	26	responsible	responsible	JJ
cord-022290-p0l1kv6n	303	27	for	for	IN
cord-022290-p0l1kv6n	303	28	the	the	DT
cord-022290-p0l1kv6n	303	29	P2	P2	NNP
cord-022290-p0l1kv6n	303	30	specificity	specificity	NN
cord-022290-p0l1kv6n	303	31	(	(	-LRB-
cord-022290-p0l1kv6n	303	32	Fig	Fig	NNP
cord-022290-p0l1kv6n	303	33	.	.	.
cord-022290-p0l1kv6n	303	34	5	5	CD
cord-022290-p0l1kv6n	303	35	)	)	-RRB-
cord-022290-p0l1kv6n	303	36	.	.	.
cord-022290-p0l1kv6n	304	1	The/3-ribbon	The/3-ribbon	NNP
cord-022290-p0l1kv6n	304	2	-	-	HYPH
cord-022290-p0l1kv6n	304	3	contributing	contribute	VBG
cord-022290-p0l1kv6n	305	1	His145	his145	DT
cord-022290-p0l1kv6n	305	2	in	in	IN
cord-022290-p0l1kv6n	305	3	HAV	HAV	NNP
cord-022290-p0l1kv6n	305	4	3C	3C	NNP
cord-022290-p0l1kv6n	305	5	is	be	VBZ
cord-022290-p0l1kv6n	305	6	shorter	short	JJR
cord-022290-p0l1kv6n	305	7	in	in	IN
cord-022290-p0l1kv6n	305	8	the	the	DT
cord-022290-p0l1kv6n	305	9	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	305	10	enzyme	enzyme	NN
cord-022290-p0l1kv6n	306	1	so	so	CC
cord-022290-p0l1kv6n	306	2	there	there	EX
cord-022290-p0l1kv6n	306	3	is	be	VBZ
cord-022290-p0l1kv6n	306	4	no	no	DT
cord-022290-p0l1kv6n	306	5	equivalent	equivalent	JJ
cord-022290-p0l1kv6n	306	6	residue	residue	NN
cord-022290-p0l1kv6n	306	7	in	in	IN
cord-022290-p0l1kv6n	306	8	polio	polio	NN
cord-022290-p0l1kv6n	306	9	3C.	3c.	CD
cord-022290-p0l1kv6n	307	1	This	this	DT
cord-022290-p0l1kv6n	307	2	correlates	correlate	VBZ
cord-022290-p0l1kv6n	307	3	well	well	RB
cord-022290-p0l1kv6n	307	4	with	with	IN
cord-022290-p0l1kv6n	307	5	the	the	DT
cord-022290-p0l1kv6n	307	6	fact	fact	NN
cord-022290-p0l1kv6n	307	7	that	that	IN
cord-022290-p0l1kv6n	307	8	polio	polio	NNP
cord-022290-p0l1kv6n	307	9	3C	3C	NNP
cord-022290-p0l1kv6n	307	10	does	do	VBZ
cord-022290-p0l1kv6n	307	11	not	not	RB
cord-022290-p0l1kv6n	307	12	show	show	VB
cord-022290-p0l1kv6n	307	13	a	a	DT
cord-022290-p0l1kv6n	307	14	sequence	sequence	NN
cord-022290-p0l1kv6n	307	15	preference	preference	NN
cord-022290-p0l1kv6n	307	16	for	for	IN
cord-022290-p0l1kv6n	307	17	a	a	DT
cord-022290-p0l1kv6n	307	18	P2	P2	NNP
cord-022290-p0l1kv6n	307	19	residue	residue	NN
cord-022290-p0l1kv6n	307	20	.	.	.
cord-022290-p0l1kv6n	308	1	The	the	DT
cord-022290-p0l1kv6n	308	2	hydrophobic	hydrophobic	JJ
cord-022290-p0l1kv6n	308	3	$	$	$
cord-022290-p0l1kv6n	308	4	4	4	CD
cord-022290-p0l1kv6n	308	5	pocket	pocket	NN
cord-022290-p0l1kv6n	308	6	of	of	IN
cord-022290-p0l1kv6n	308	7	the	the	DT
cord-022290-p0l1kv6n	308	8	3C	3C	NNP
cord-022290-p0l1kv6n	308	9	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	308	10	is	be	VBZ
cord-022290-p0l1kv6n	308	11	a	a	DT
cord-022290-p0l1kv6n	308	12	cleft	cleft	NN
cord-022290-p0l1kv6n	308	13	formed	form	VBN
cord-022290-p0l1kv6n	308	14	by	by	IN
cord-022290-p0l1kv6n	308	15	fl	fl	NNP
cord-022290-p0l1kv6n	308	16	-	-	HYPH
cord-022290-p0l1kv6n	308	17	strands	strand	NNS
cord-022290-p0l1kv6n	308	18	eII	eII	NNS
cord-022290-p0l1kv6n	308	19	and	and	CC
cord-022290-p0l1kv6n	308	20	fII	fii	NN
cord-022290-p0l1kv6n	308	21	and	and	CC
cord-022290-p0l1kv6n	308	22	the	the	DT
cord-022290-p0l1kv6n	308	23	fl	fl	NNP
cord-022290-p0l1kv6n	308	24	-	-	HYPH
cord-022290-p0l1kv6n	308	25	ribbon	ribbon	NN
cord-022290-p0l1kv6n	308	26	formed	form	VBN
cord-022290-p0l1kv6n	308	27	by	by	IN
cord-022290-p0l1kv6n	308	28	the	the	DT
cord-022290-p0l1kv6n	308	29	extension	extension	NN
cord-022290-p0l1kv6n	308	30	of/3-strands	of/3-strands	XX
cord-022290-p0l1kv6n	309	1	bII	bII	NNP
cord-022290-p0l1kv6n	309	2	and	and	CC
cord-022290-p0l1kv6n	309	3	cII	cii	CD
cord-022290-p0l1kv6n	310	1	(	(	-LRB-
cord-022290-p0l1kv6n	310	2	Fig	Fig	NNP
cord-022290-p0l1kv6n	310	3	.	.	NNP
cord-022290-p0l1kv6n	310	4	5	5	CD
cord-022290-p0l1kv6n	310	5	)	)	-RRB-
cord-022290-p0l1kv6n	310	6	.	.	.
cord-022290-p0l1kv6n	311	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	311	2	is	be	VBZ
cord-022290-p0l1kv6n	311	3	quite	quite	RB
cord-022290-p0l1kv6n	311	4	large	large	JJ
cord-022290-p0l1kv6n	311	5	in	in	IN
cord-022290-p0l1kv6n	311	6	the	the	DT
cord-022290-p0l1kv6n	311	7	HAV	HAV	NNP
cord-022290-p0l1kv6n	311	8	3C	3c	NN
cord-022290-p0l1kv6n	311	9	proteinase	proteinase	NN
cord-022290-p0l1kv6n	311	10	.	.	.
cord-022290-p0l1kv6n	312	1	In	in	IN
cord-022290-p0l1kv6n	312	2	polio	polio	NN
cord-022290-p0l1kv6n	312	3	3C	3c	NN
cord-022290-p0l1kv6n	312	4	several	several	JJ
cord-022290-p0l1kv6n	312	5	of	of	IN
cord-022290-p0l1kv6n	312	6	the	the	DT
cord-022290-p0l1kv6n	312	7	hydrophobic	hydrophobic	JJ
cord-022290-p0l1kv6n	312	8	residues	residue	NNS
cord-022290-p0l1kv6n	312	9	that	that	WDT
cord-022290-p0l1kv6n	312	10	form	form	VBP
cord-022290-p0l1kv6n	312	11	this	this	DT
cord-022290-p0l1kv6n	312	12	pocket	pocket	NN
cord-022290-p0l1kv6n	312	13	are	be	VBP
cord-022290-p0l1kv6n	312	14	substituted	substitute	VBN
cord-022290-p0l1kv6n	312	15	by	by	IN
cord-022290-p0l1kv6n	312	16	larger	large	JJR
cord-022290-p0l1kv6n	312	17	ones	one	NNS
cord-022290-p0l1kv6n	312	18	(	(	-LRB-
cord-022290-p0l1kv6n	312	19	e.g.	e.g.	RB
cord-022290-p0l1kv6n	312	20	,	,	,
cord-022290-p0l1kv6n	312	21	Ala141	ala141	NN
cord-022290-p0l1kv6n	312	22	and	and	CC
cord-022290-p0l1kv6n	312	23	Val200	val200	CD
cord-022290-p0l1kv6n	312	24	in	in	IN
cord-022290-p0l1kv6n	312	25	HAV	HAV	NNP
cord-022290-p0l1kv6n	312	26	3C	3c	NN
cord-022290-p0l1kv6n	312	27	correspond	correspond	VB
cord-022290-p0l1kv6n	312	28	to	to	IN
cord-022290-p0l1kv6n	312	29	Leu125	Leu125	NNP
cord-022290-p0l1kv6n	312	30	and	and	CC
cord-022290-p0l1kv6n	312	31	Phe170	phe170	CD
cord-022290-p0l1kv6n	312	32	in	in	IN
cord-022290-p0l1kv6n	312	33	polio	polio	NNP
cord-022290-p0l1kv6n	312	34	3C	3C	NNP
cord-022290-p0l1kv6n	312	35	)	)	-RRB-
cord-022290-p0l1kv6n	312	36	.	.	.
cord-022290-p0l1kv6n	313	1	Therefore	therefore	RB
cord-022290-p0l1kv6n	313	2	,	,	,
cord-022290-p0l1kv6n	313	3	the	the	DT
cord-022290-p0l1kv6n	313	4	$	$	$
cord-022290-p0l1kv6n	313	5	4	4	CD
cord-022290-p0l1kv6n	313	6	pocket	pocket	NN
cord-022290-p0l1kv6n	313	7	in	in	IN
cord-022290-p0l1kv6n	313	8	the	the	DT
cord-022290-p0l1kv6n	313	9	polio	polio	NN
cord-022290-p0l1kv6n	313	10	3C	3C	NNP
cord-022290-p0l1kv6n	313	11	is	be	VBZ
cord-022290-p0l1kv6n	313	12	smaller	small	JJR
cord-022290-p0l1kv6n	313	13	and	and	CC
cord-022290-p0l1kv6n	313	14	polio	polio	NNP
cord-022290-p0l1kv6n	313	15	3C	3C	NNP
cord-022290-p0l1kv6n	313	16	prefers	prefer	VBZ
cord-022290-p0l1kv6n	313	17	smaller	small	JJR
cord-022290-p0l1kv6n	313	18	,	,	,
cord-022290-p0l1kv6n	313	19	hydrophobic	hydrophobic	JJ
cord-022290-p0l1kv6n	313	20	side	side	NN
cord-022290-p0l1kv6n	313	21	-	-	HYPH
cord-022290-p0l1kv6n	313	22	chains	chain	NNS
cord-022290-p0l1kv6n	313	23	in	in	IN
cord-022290-p0l1kv6n	313	24	P4	P4	NNP
cord-022290-p0l1kv6n	313	25	.	.	.
cord-022290-p0l1kv6n	314	1	The	the	DT
cord-022290-p0l1kv6n	314	2	larger	large	JJR
cord-022290-p0l1kv6n	314	3	3C	3c	NN
cord-022290-p0l1kv6n	314	4	proteinase	proteinase	NN
cord-022290-p0l1kv6n	314	5	from	from	IN
cord-022290-p0l1kv6n	314	6	HAV	HAV	NNP
cord-022290-p0l1kv6n	314	7	thus	thus	RB
cord-022290-p0l1kv6n	314	8	forms	form	VBZ
cord-022290-p0l1kv6n	314	9	more	more	RBR
cord-022290-p0l1kv6n	314	10	extensive	extensive	JJ
cord-022290-p0l1kv6n	314	11	interactions	interaction	NNS
cord-022290-p0l1kv6n	314	12	with	with	IN
cord-022290-p0l1kv6n	314	13	peptide	peptide	NN
cord-022290-p0l1kv6n	314	14	substrates	substrate	NNS
cord-022290-p0l1kv6n	314	15	,	,	,
cord-022290-p0l1kv6n	314	16	both	both	DT
cord-022290-p0l1kv6n	314	17	main	main	JJ
cord-022290-p0l1kv6n	314	18	-	-	HYPH
cord-022290-p0l1kv6n	314	19	chain	chain	NN
cord-022290-p0l1kv6n	314	20	and	and	CC
cord-022290-p0l1kv6n	314	21	side	side	NN
cord-022290-p0l1kv6n	314	22	-	-	HYPH
cord-022290-p0l1kv6n	314	23	chain	chain	NN
cord-022290-p0l1kv6n	314	24	.	.	.
cord-022290-p0l1kv6n	315	1	However	however	RB
cord-022290-p0l1kv6n	315	2	,	,	,
cord-022290-p0l1kv6n	315	3	it	-PRON-	PRP
cord-022290-p0l1kv6n	315	4	is	be	VBZ
cord-022290-p0l1kv6n	315	5	important	important	JJ
cord-022290-p0l1kv6n	315	6	to	to	TO
cord-022290-p0l1kv6n	315	7	keep	keep	VB
cord-022290-p0l1kv6n	315	8	in	in	IN
cord-022290-p0l1kv6n	315	9	mind	mind	NN
cord-022290-p0l1kv6n	315	10	that	that	IN
cord-022290-p0l1kv6n	315	11	in	in	IN
cord-022290-p0l1kv6n	315	12	the	the	DT
cord-022290-p0l1kv6n	315	13	enteroviruses	enteroviruses	NNP
cord-022290-p0l1kv6n	315	14	the	the	DT
cord-022290-p0l1kv6n	315	15	3CD	3CD	NNP
cord-022290-p0l1kv6n	315	16	precursor	precursor	NN
cord-022290-p0l1kv6n	315	17	is	be	VBZ
cord-022290-p0l1kv6n	315	18	a	a	DT
cord-022290-p0l1kv6n	315	19	more	more	RBR
cord-022290-p0l1kv6n	315	20	active	active	JJ
cord-022290-p0l1kv6n	315	21	proteinase	proteinase	NN
cord-022290-p0l1kv6n	315	22	and	and	CC
cord-022290-p0l1kv6n	315	23	is	be	VBZ
cord-022290-p0l1kv6n	315	24	required	require	VBN
cord-022290-p0l1kv6n	315	25	for	for	IN
cord-022290-p0l1kv6n	315	26	some	some	DT
cord-022290-p0l1kv6n	315	27	of	of	IN
cord-022290-p0l1kv6n	315	28	the	the	DT
cord-022290-p0l1kv6n	315	29	cleavages	cleavage	NNS
cord-022290-p0l1kv6n	315	30	of	of	IN
cord-022290-p0l1kv6n	315	31	the	the	DT
cord-022290-p0l1kv6n	315	32	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	316	1	(	(	-LRB-
cord-022290-p0l1kv6n	316	2	Ypma	Ypma	NNP
cord-022290-p0l1kv6n	316	3	-	-	HYPH
cord-022290-p0l1kv6n	316	4	Wong	Wong	NNP
cord-022290-p0l1kv6n	316	5	et	et	NNP
cord-022290-p0l1kv6n	316	6	al	al	NNP
cord-022290-p0l1kv6n	316	7	.	.	NNP
cord-022290-p0l1kv6n	316	8	,	,	,
cord-022290-p0l1kv6n	316	9	1988	1988	CD
cord-022290-p0l1kv6n	316	10	)	)	-RRB-
cord-022290-p0l1kv6n	316	11	.	.	.
cord-022290-p0l1kv6n	317	1	Bergmann	Bergmann	NNP
cord-022290-p0l1kv6n	317	2	et	et	NNP
cord-022290-p0l1kv6n	317	3	al	al	NNP
cord-022290-p0l1kv6n	317	4	.	.	.
cord-022290-p0l1kv6n	318	1	(	(	-LRB-
cord-022290-p0l1kv6n	318	2	1997	1997	CD
cord-022290-p0l1kv6n	318	3	)	)	-RRB-
cord-022290-p0l1kv6n	318	4	suggested	suggest	VBD
cord-022290-p0l1kv6n	318	5	a	a	DT
cord-022290-p0l1kv6n	318	6	model	model	NN
cord-022290-p0l1kv6n	318	7	for	for	IN
cord-022290-p0l1kv6n	318	8	the	the	DT
cord-022290-p0l1kv6n	318	9	interactions	interaction	NNS
cord-022290-p0l1kv6n	318	10	of	of	IN
cord-022290-p0l1kv6n	318	11	3C	3C	NNP
cord-022290-p0l1kv6n	318	12	with	with	IN
cord-022290-p0l1kv6n	318	13	the	the	DT
cord-022290-p0l1kv6n	318	14	3D	3d	JJ
cord-022290-p0l1kv6n	318	15	and	and	CC
cord-022290-p0l1kv6n	318	16	3AB	3AB	NNP
cord-022290-p0l1kv6n	318	17	domains	domain	NNS
cord-022290-p0l1kv6n	318	18	in	in	IN
cord-022290-p0l1kv6n	318	19	a	a	DT
cord-022290-p0l1kv6n	318	20	larger	large	JJR
cord-022290-p0l1kv6n	318	21	precursor	precursor	NN
cord-022290-p0l1kv6n	318	22	.	.	.
cord-022290-p0l1kv6n	319	1	In	in	IN
cord-022290-p0l1kv6n	319	2	this	this	DT
cord-022290-p0l1kv6n	319	3	model	model	NN
cord-022290-p0l1kv6n	319	4	the	the	DT
cord-022290-p0l1kv6n	319	5	3D	3d	JJ
cord-022290-p0l1kv6n	319	6	part	part	NN
cord-022290-p0l1kv6n	319	7	of	of	IN
cord-022290-p0l1kv6n	319	8	a	a	DT
cord-022290-p0l1kv6n	319	9	3CD	3cd	CD
cord-022290-p0l1kv6n	319	10	precursor	precursor	NN
cord-022290-p0l1kv6n	319	11	would	would	MD
cord-022290-p0l1kv6n	319	12	be	be	VB
cord-022290-p0l1kv6n	319	13	in	in	IN
cord-022290-p0l1kv6n	319	14	a	a	DT
cord-022290-p0l1kv6n	319	15	position	position	NN
cord-022290-p0l1kv6n	319	16	to	to	TO
cord-022290-p0l1kv6n	319	17	interact	interact	VB
cord-022290-p0l1kv6n	319	18	with	with	IN
cord-022290-p0l1kv6n	319	19	the	the	DT
cord-022290-p0l1kv6n	319	20	residues	residue	NNS
cord-022290-p0l1kv6n	319	21	in	in	IN
cord-022290-p0l1kv6n	319	22	the	the	DT
cord-022290-p0l1kv6n	319	23	P2	P2	NNP
cord-022290-p0l1kv6n	319	24	and	and	CC
cord-022290-p0l1kv6n	319	25	P3	P3	NNP
cord-022290-p0l1kv6n	319	26	position	position	NN
cord-022290-p0l1kv6n	319	27	of	of	IN
cord-022290-p0l1kv6n	319	28	a	a	DT
cord-022290-p0l1kv6n	319	29	substrate	substrate	NN
cord-022290-p0l1kv6n	319	30	and	and	CC
cord-022290-p0l1kv6n	319	31	could	could	MD
cord-022290-p0l1kv6n	319	32	influence	influence	VB
cord-022290-p0l1kv6n	319	33	the	the	DT
cord-022290-p0l1kv6n	319	34	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	319	35	activity	activity	NN
cord-022290-p0l1kv6n	319	36	(	(	-LRB-
cord-022290-p0l1kv6n	319	37	top	top	JJ
cord-022290-p0l1kv6n	319	38	left	left	NN
cord-022290-p0l1kv6n	319	39	of	of	IN
cord-022290-p0l1kv6n	319	40	the	the	DT
cord-022290-p0l1kv6n	319	41	3C	3c	NN
cord-022290-p0l1kv6n	319	42	molecule	molecule	NN
cord-022290-p0l1kv6n	319	43	in	in	IN
cord-022290-p0l1kv6n	319	44	Figs	Figs	NNP
cord-022290-p0l1kv6n	319	45	.	.	.
cord-022290-p0l1kv6n	320	1	2a	2a	NNP
cord-022290-p0l1kv6n	320	2	and	and	CC
cord-022290-p0l1kv6n	320	3	3a	3a	NNP
cord-022290-p0l1kv6n	320	4	)	)	-RRB-
cord-022290-p0l1kv6n	320	5	.	.	.
cord-022290-p0l1kv6n	321	1	While	while	IN
cord-022290-p0l1kv6n	321	2	the	the	DT
cord-022290-p0l1kv6n	321	3	models	model	NNS
cord-022290-p0l1kv6n	321	4	of	of	IN
cord-022290-p0l1kv6n	321	5	substrate	substrate	NN
cord-022290-p0l1kv6n	321	6	binding	bind	VBG
cord-022290-p0l1kv6n	321	7	to	to	IN
cord-022290-p0l1kv6n	321	8	the	the	DT
cord-022290-p0l1kv6n	321	9	3C	3C	NNP
cord-022290-p0l1kv6n	321	10	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	321	11	allow	allow	VBP
cord-022290-p0l1kv6n	321	12	one	one	CD
cord-022290-p0l1kv6n	321	13	to	to	TO
cord-022290-p0l1kv6n	321	14	rationalize	rationalize	VB
cord-022290-p0l1kv6n	321	15	how	how	WRB
cord-022290-p0l1kv6n	321	16	the	the	DT
cord-022290-p0l1kv6n	321	17	3C	3C	NNP
cord-022290-p0l1kv6n	321	18	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	321	19	recognize	recognize	VBP
cord-022290-p0l1kv6n	321	20	the	the	DT
cord-022290-p0l1kv6n	321	21	specific	specific	JJ
cord-022290-p0l1kv6n	321	22	cleavage	cleavage	NN
cord-022290-p0l1kv6n	321	23	sites	site	NNS
cord-022290-p0l1kv6n	321	24	within	within	IN
cord-022290-p0l1kv6n	321	25	the	the	DT
cord-022290-p0l1kv6n	321	26	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	321	27	,	,	,
cord-022290-p0l1kv6n	321	28	it	-PRON-	PRP
cord-022290-p0l1kv6n	321	29	is	be	VBZ
cord-022290-p0l1kv6n	321	30	not	not	RB
cord-022290-p0l1kv6n	321	31	possible	possible	JJ
cord-022290-p0l1kv6n	321	32	to	to	TO
cord-022290-p0l1kv6n	321	33	explain	explain	VB
cord-022290-p0l1kv6n	321	34	the	the	DT
cord-022290-p0l1kv6n	321	35	preference	preference	NN
cord-022290-p0l1kv6n	321	36	of	of	IN
cord-022290-p0l1kv6n	321	37	some	some	DT
cord-022290-p0l1kv6n	321	38	of	of	IN
cord-022290-p0l1kv6n	321	39	the	the	DT
cord-022290-p0l1kv6n	321	40	cleavage	cleavage	NN
cord-022290-p0l1kv6n	321	41	sites	site	NNS
cord-022290-p0l1kv6n	321	42	over	over	IN
cord-022290-p0l1kv6n	321	43	others	other	NNS
cord-022290-p0l1kv6n	321	44	during	during	IN
cord-022290-p0l1kv6n	321	45	the	the	DT
cord-022290-p0l1kv6n	321	46	polyprotein	polyprotein	JJ
cord-022290-p0l1kv6n	321	47	processing	processing	NN
cord-022290-p0l1kv6n	321	48	.	.	.
cord-022290-p0l1kv6n	322	1	Presumably	presumably	RB
cord-022290-p0l1kv6n	322	2	other	other	JJ
cord-022290-p0l1kv6n	322	3	factors	factor	NNS
cord-022290-p0l1kv6n	322	4	besides	besides	IN
cord-022290-p0l1kv6n	322	5	the	the	DT
cord-022290-p0l1kv6n	322	6	subsite	subsite	NN
cord-022290-p0l1kv6n	322	7	specificity	specificity	NN
cord-022290-p0l1kv6n	322	8	,	,	,
cord-022290-p0l1kv6n	322	9	such	such	JJ
cord-022290-p0l1kv6n	322	10	as	as	IN
cord-022290-p0l1kv6n	322	11	the	the	DT
cord-022290-p0l1kv6n	322	12	accessibility	accessibility	NN
cord-022290-p0l1kv6n	322	13	within	within	IN
cord-022290-p0l1kv6n	322	14	the	the	DT
cord-022290-p0l1kv6n	322	15	folded	folded	JJ
cord-022290-p0l1kv6n	322	16	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	322	17	,	,	,
cord-022290-p0l1kv6n	322	18	must	must	MD
cord-022290-p0l1kv6n	322	19	play	play	VB
cord-022290-p0l1kv6n	322	20	a	a	DT
cord-022290-p0l1kv6n	322	21	part	part	NN
cord-022290-p0l1kv6n	322	22	in	in	IN
cord-022290-p0l1kv6n	322	23	the	the	DT
cord-022290-p0l1kv6n	322	24	determination	determination	NN
cord-022290-p0l1kv6n	322	25	of	of	IN
cord-022290-p0l1kv6n	322	26	the	the	DT
cord-022290-p0l1kv6n	322	27	sequential	sequential	JJ
cord-022290-p0l1kv6n	322	28	polyprotein	polyprotein	JJ
cord-022290-p0l1kv6n	322	29	processing	processing	NN
cord-022290-p0l1kv6n	322	30	.	.	.
cord-022290-p0l1kv6n	323	1	Inhibitors	Inhibitors	NNP
cord-022290-p0l1kv6n	323	2	of	of	IN
cord-022290-p0l1kv6n	323	3	the	the	DT
cord-022290-p0l1kv6n	323	4	3C	3C	NNP
cord-022290-p0l1kv6n	323	5	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	323	6	usually	usually	RB
cord-022290-p0l1kv6n	323	7	combine	combine	VBP
cord-022290-p0l1kv6n	323	8	a	a	DT
cord-022290-p0l1kv6n	323	9	chemical	chemical	NN
cord-022290-p0l1kv6n	323	10	functionality	functionality	NN
cord-022290-p0l1kv6n	323	11	that	that	WDT
cord-022290-p0l1kv6n	323	12	covalently	covalently	RB
cord-022290-p0l1kv6n	323	13	attaches	attach	VBZ
cord-022290-p0l1kv6n	323	14	to	to	IN
cord-022290-p0l1kv6n	323	15	the	the	DT
cord-022290-p0l1kv6n	323	16	nucleophilic	nucleophilic	JJ
cord-022290-p0l1kv6n	323	17	thiol	thiol	NN
cord-022290-p0l1kv6n	323	18	in	in	IN
cord-022290-p0l1kv6n	323	19	the	the	DT
cord-022290-p0l1kv6n	323	20	active	active	JJ
cord-022290-p0l1kv6n	323	21	site	site	NN
cord-022290-p0l1kv6n	323	22	,	,	,
cord-022290-p0l1kv6n	323	23	with	with	IN
cord-022290-p0l1kv6n	323	24	other	other	JJ
cord-022290-p0l1kv6n	323	25	groups	group	NNS
cord-022290-p0l1kv6n	323	26	which	which	WDT
cord-022290-p0l1kv6n	323	27	target	target	VBP
cord-022290-p0l1kv6n	323	28	some	some	DT
cord-022290-p0l1kv6n	323	29	of	of	IN
cord-022290-p0l1kv6n	323	30	the	the	DT
cord-022290-p0l1kv6n	323	31	specific	specific	JJ
cord-022290-p0l1kv6n	323	32	interactions	interaction	NNS
cord-022290-p0l1kv6n	323	33	between	between	IN
cord-022290-p0l1kv6n	323	34	the	the	DT
cord-022290-p0l1kv6n	323	35	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	323	36	and	and	CC
cord-022290-p0l1kv6n	323	37	its	-PRON-	PRP$
cord-022290-p0l1kv6n	323	38	substrates	substrate	NNS
cord-022290-p0l1kv6n	323	39	.	.	.
cord-022290-p0l1kv6n	324	1	Typical	typical	JJ
cord-022290-p0l1kv6n	324	2	cysteine	cysteine	NN
cord-022290-p0l1kv6n	324	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	324	4	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	324	5	such	such	JJ
cord-022290-p0l1kv6n	324	6	as	as	IN
cord-022290-p0l1kv6n	324	7	iodoacetamide	iodoacetamide	NNP
cord-022290-p0l1kv6n	324	8	,	,	,
cord-022290-p0l1kv6n	324	9	N	N	NNP
cord-022290-p0l1kv6n	324	10	-	-	HYPH
cord-022290-p0l1kv6n	324	11	ethylmaleimide	ethylmaleimide	NNP
cord-022290-p0l1kv6n	324	12	,	,	,
cord-022290-p0l1kv6n	324	13	epoxides	epoxide	NNS
cord-022290-p0l1kv6n	324	14	,	,	,
cord-022290-p0l1kv6n	324	15	and	and	CC
cord-022290-p0l1kv6n	324	16	aldehydes	aldehyde	NNS
cord-022290-p0l1kv6n	324	17	are	be	VBP
cord-022290-p0l1kv6n	324	18	also	also	RB
cord-022290-p0l1kv6n	324	19	effective	effective	JJ
cord-022290-p0l1kv6n	324	20	against	against	IN
cord-022290-p0l1kv6n	324	21	the	the	DT
cord-022290-p0l1kv6n	324	22	3C	3C	NNP
cord-022290-p0l1kv6n	324	23	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	324	24	(	(	-LRB-
cord-022290-p0l1kv6n	324	25	Malcolm	Malcolm	NNP
cord-022290-p0l1kv6n	324	26	,	,	,
cord-022290-p0l1kv6n	324	27	1995	1995	CD
cord-022290-p0l1kv6n	324	28	)	)	-RRB-
cord-022290-p0l1kv6n	324	29	.	.	.
cord-022290-p0l1kv6n	325	1	More	more	RBR
cord-022290-p0l1kv6n	325	2	promising	promising	JJ
cord-022290-p0l1kv6n	325	3	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	325	4	are	be	VBP
cord-022290-p0l1kv6n	325	5	the	the	DT
cord-022290-p0l1kv6n	325	6	fluoromethylketones	fluoromethylketones	NNP
cord-022290-p0l1kv6n	325	7	and	and	CC
cord-022290-p0l1kv6n	325	8	y	y	NNP
cord-022290-p0l1kv6n	325	9	-	-	HYPH
cord-022290-p0l1kv6n	325	10	aminovinylsulfones	aminovinylsulfones	NNP
cord-022290-p0l1kv6n	325	11	(	(	-LRB-
cord-022290-p0l1kv6n	325	12	Rasnik	Rasnik	NNP
cord-022290-p0l1kv6n	325	13	,	,	,
cord-022290-p0l1kv6n	325	14	1996	1996	CD
cord-022290-p0l1kv6n	325	15	)	)	-RRB-
cord-022290-p0l1kv6n	325	16	.	.	.
cord-022290-p0l1kv6n	326	1	Some	some	DT
cord-022290-p0l1kv6n	326	2	of	of	IN
cord-022290-p0l1kv6n	326	3	the	the	DT
cord-022290-p0l1kv6n	326	4	best	good	JJS
cord-022290-p0l1kv6n	326	5	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	326	6	available	available	JJ
cord-022290-p0l1kv6n	326	7	to	to	IN
cord-022290-p0l1kv6n	326	8	date	date	NN
cord-022290-p0l1kv6n	326	9	combine	combine	VB
cord-022290-p0l1kv6n	326	10	the	the	DT
cord-022290-p0l1kv6n	326	11	latter	latter	JJ
cord-022290-p0l1kv6n	326	12	functionalities	functionality	NNS
cord-022290-p0l1kv6n	326	13	with	with	IN
cord-022290-p0l1kv6n	326	14	a	a	DT
cord-022290-p0l1kv6n	326	15	peptidic	peptidic	JJ
cord-022290-p0l1kv6n	326	16	specificity	specificity	NN
cord-022290-p0l1kv6n	326	17	address	address	NN
cord-022290-p0l1kv6n	326	18	which	which	WDT
cord-022290-p0l1kv6n	326	19	mimics	mimic	VBZ
cord-022290-p0l1kv6n	326	20	the	the	DT
cord-022290-p0l1kv6n	326	21	natural	natural	JJ
cord-022290-p0l1kv6n	326	22	peptide	peptide	NN
cord-022290-p0l1kv6n	326	23	specificity	specificity	NN
cord-022290-p0l1kv6n	326	24	.	.	.
cord-022290-p0l1kv6n	327	1	A	a	DT
cord-022290-p0l1kv6n	327	2	tetrapeptide	tetrapeptide	NN
cord-022290-p0l1kv6n	327	3	fluoromethylketone	fluoromethylketone	NN
cord-022290-p0l1kv6n	327	4	inhibitor	inhibitor	NN
cord-022290-p0l1kv6n	327	5	with	with	IN
cord-022290-p0l1kv6n	327	6	the	the	DT
cord-022290-p0l1kv6n	327	7	sequence	sequence	NN
cord-022290-p0l1kv6n	327	8	Acetyl	Acetyl	NNP
cord-022290-p0l1kv6n	327	9	-	-	HYPH
cord-022290-p0l1kv6n	327	10	Leu	Leu	NNP
cord-022290-p0l1kv6n	327	11	-	-	HYPH
cord-022290-p0l1kv6n	327	12	Ala	Ala	NNP
cord-022290-p0l1kv6n	327	13	-	-	HYPH
cord-022290-p0l1kv6n	327	14	Ala	Ala	NNP
cord-022290-p0l1kv6n	327	15	-	-	HYPH
cord-022290-p0l1kv6n	327	16	Gln	Gln	NNP
cord-022290-p0l1kv6n	327	17	-	-	HYPH
cord-022290-p0l1kv6n	327	18	FMK	FMK	NNP
cord-022290-p0l1kv6n	327	19	has	have	VBZ
cord-022290-p0l1kv6n	327	20	been	be	VBN
cord-022290-p0l1kv6n	327	21	shown	show	VBN
cord-022290-p0l1kv6n	327	22	to	to	TO
cord-022290-p0l1kv6n	327	23	be	be	VB
cord-022290-p0l1kv6n	327	24	an	an	DT
cord-022290-p0l1kv6n	327	25	effective	effective	JJ
cord-022290-p0l1kv6n	327	26	inhibitor	inhibitor	NN
cord-022290-p0l1kv6n	327	27	of	of	IN
cord-022290-p0l1kv6n	327	28	the	the	DT
cord-022290-p0l1kv6n	327	29	HAV	HAV	NNP
cord-022290-p0l1kv6n	327	30	3C	3c	NN
cord-022290-p0l1kv6n	327	31	proteinase	proteinase	NN
cord-022290-p0l1kv6n	327	32	in	in	IN
cord-022290-p0l1kv6n	327	33	vitro	vitro	FW
cord-022290-p0l1kv6n	327	34	and	and	CC
cord-022290-p0l1kv6n	327	35	in	in	IN
cord-022290-p0l1kv6n	327	36	vivo	vivo	NN
cord-022290-p0l1kv6n	328	1	(	(	-LRB-
cord-022290-p0l1kv6n	328	2	Morris	Morris	NNP
cord-022290-p0l1kv6n	328	3	et	et	NNP
cord-022290-p0l1kv6n	328	4	al	al	NNP
cord-022290-p0l1kv6n	328	5	.	.	NNP
cord-022290-p0l1kv6n	328	6	,	,	,
cord-022290-p0l1kv6n	328	7	1997	1997	CD
cord-022290-p0l1kv6n	328	8	)	)	-RRB-
cord-022290-p0l1kv6n	328	9	.	.	.
cord-022290-p0l1kv6n	329	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	329	2	covalently	covalently	RB
cord-022290-p0l1kv6n	329	3	attaches	attach	VBZ
cord-022290-p0l1kv6n	329	4	to	to	IN
cord-022290-p0l1kv6n	329	5	the	the	DT
cord-022290-p0l1kv6n	329	6	HAV	HAV	NNP
cord-022290-p0l1kv6n	329	7	3C	3c	NN
cord-022290-p0l1kv6n	329	8	proteinase	proteinase	NN
cord-022290-p0l1kv6n	329	9	and	and	CC
cord-022290-p0l1kv6n	329	10	is	be	VBZ
cord-022290-p0l1kv6n	329	11	capable	capable	JJ
cord-022290-p0l1kv6n	329	12	of	of	IN
cord-022290-p0l1kv6n	329	13	reducing	reduce	VBG
cord-022290-p0l1kv6n	329	14	the	the	DT
cord-022290-p0l1kv6n	329	15	production	production	NN
cord-022290-p0l1kv6n	329	16	of	of	IN
cord-022290-p0l1kv6n	329	17	progeny	progeny	JJ
cord-022290-p0l1kv6n	329	18	virus	virus	NN
cord-022290-p0l1kv6n	329	19	in	in	IN
cord-022290-p0l1kv6n	329	20	infected	infected	JJ
cord-022290-p0l1kv6n	329	21	cells	cell	NNS
cord-022290-p0l1kv6n	329	22	.	.	.
cord-022290-p0l1kv6n	330	1	Other	other	JJ
cord-022290-p0l1kv6n	330	2	functionalities	functionality	NNS
cord-022290-p0l1kv6n	330	3	that	that	WDT
cord-022290-p0l1kv6n	330	4	are	be	VBP
cord-022290-p0l1kv6n	330	5	now	now	RB
cord-022290-p0l1kv6n	330	6	being	be	VBG
cord-022290-p0l1kv6n	330	7	investigated	investigate	VBN
cord-022290-p0l1kv6n	330	8	as	as	IN
cord-022290-p0l1kv6n	330	9	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	330	10	of	of	IN
cord-022290-p0l1kv6n	330	11	the	the	DT
cord-022290-p0l1kv6n	330	12	chymotrypsin	chymotrypsin	NNP
cord-022290-p0l1kv6n	330	13	-	-	HYPH
cord-022290-p0l1kv6n	330	14	like	like	JJ
cord-022290-p0l1kv6n	330	15	cysteine	cysteine	NN
cord-022290-p0l1kv6n	330	16	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	330	17	include	include	VBP
cord-022290-p0l1kv6n	330	18	aft	aft	NN
cord-022290-p0l1kv6n	330	19	-	-	HYPH
cord-022290-p0l1kv6n	330	20	unsaturated	unsaturated	JJ
cord-022290-p0l1kv6n	330	21	carboxylesters	carboxylester	NNS
cord-022290-p0l1kv6n	330	22	,	,	,
cord-022290-p0l1kv6n	330	23	/3-and	/3-and	.
cord-022290-p0l1kv6n	331	1	y	y	NNP
cord-022290-p0l1kv6n	331	2	-	-	HYPH
cord-022290-p0l1kv6n	331	3	lactones	lactones	NNPS
cord-022290-p0l1kv6n	331	4	,	,	,
cord-022290-p0l1kv6n	331	5	lactams	lactam	NNS
cord-022290-p0l1kv6n	331	6	,	,	,
cord-022290-p0l1kv6n	331	7	isatins	isatins	NNP
cord-022290-p0l1kv6n	331	8	(	(	-LRB-
cord-022290-p0l1kv6n	331	9	2,3-dioxindoles	2,3-dioxindole	NNS
cord-022290-p0l1kv6n	331	10	)	)	-RRB-
cord-022290-p0l1kv6n	331	11	,	,	,
cord-022290-p0l1kv6n	331	12	and	and	CC
cord-022290-p0l1kv6n	331	13	triterpene	triterpene	NNP
cord-022290-p0l1kv6n	331	14	sulfates	sulfate	NNS
cord-022290-p0l1kv6n	331	15	(	(	-LRB-
cord-022290-p0l1kv6n	331	16	Skiles	Skiles	NNP
cord-022290-p0l1kv6n	331	17	and	and	CC
cord-022290-p0l1kv6n	331	18	McNeil	McNeil	NNP
cord-022290-p0l1kv6n	331	19	,	,	,
cord-022290-p0l1kv6n	331	20	1990	1990	CD
cord-022290-p0l1kv6n	331	21	;	;	:
cord-022290-p0l1kv6n	331	22	Brill	Brill	NNP
cord-022290-p0l1kv6n	331	23	et	et	NNP
cord-022290-p0l1kv6n	331	24	al	al	NNP
cord-022290-p0l1kv6n	331	25	.	.	NNP
cord-022290-p0l1kv6n	331	26	,	,	,
cord-022290-p0l1kv6n	331	27	1996	1996	CD
cord-022290-p0l1kv6n	331	28	)	)	-RRB-
cord-022290-p0l1kv6n	331	29	.	.	.
cord-022290-p0l1kv6n	332	1	A	a	DT
cord-022290-p0l1kv6n	332	2	cocrystal	cocrystal	JJ
cord-022290-p0l1kv6n	332	3	structure	structure	NN
cord-022290-p0l1kv6n	332	4	of	of	IN
cord-022290-p0l1kv6n	332	5	the	the	DT
cord-022290-p0l1kv6n	332	6	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	332	7	3C	3C	NNP
cord-022290-p0l1kv6n	332	8	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	332	9	with	with	IN
cord-022290-p0l1kv6n	332	10	an	an	DT
cord-022290-p0l1kv6n	332	11	isatin	isatin	NNP
cord-022290-p0l1kv6n	332	12	analog	analog	NN
cord-022290-p0l1kv6n	332	13	inhibitor	inhibitor	NN
cord-022290-p0l1kv6n	332	14	in	in	IN
cord-022290-p0l1kv6n	332	15	the	the	DT
cord-022290-p0l1kv6n	332	16	active	active	JJ
cord-022290-p0l1kv6n	332	17	site	site	NN
cord-022290-p0l1kv6n	332	18	shows	show	VBZ
cord-022290-p0l1kv6n	332	19	that	that	IN
cord-022290-p0l1kv6n	332	20	some	some	DT
cord-022290-p0l1kv6n	332	21	of	of	IN
cord-022290-p0l1kv6n	332	22	these	these	DT
cord-022290-p0l1kv6n	332	23	compounds	compound	NNS
cord-022290-p0l1kv6n	332	24	also	also	RB
cord-022290-p0l1kv6n	332	25	covalently	covalently	RB
cord-022290-p0l1kv6n	332	26	attach	attach	VBP
cord-022290-p0l1kv6n	332	27	to	to	IN
cord-022290-p0l1kv6n	332	28	the	the	DT
cord-022290-p0l1kv6n	332	29	active	active	JJ
cord-022290-p0l1kv6n	332	30	site	site	NN
cord-022290-p0l1kv6n	332	31	thiol	thiol	NN
cord-022290-p0l1kv6n	332	32	and	and	CC
cord-022290-p0l1kv6n	332	33	mimic	mimic	VB
cord-022290-p0l1kv6n	332	34	the	the	DT
cord-022290-p0l1kv6n	332	35	P1	P1	NNP
cord-022290-p0l1kv6n	332	36	specificity	specificity	NN
cord-022290-p0l1kv6n	332	37	determinant	determinant	NN
cord-022290-p0l1kv6n	332	38	of	of	IN
cord-022290-p0l1kv6n	332	39	a	a	DT
cord-022290-p0l1kv6n	332	40	natural	natural	JJ
cord-022290-p0l1kv6n	332	41	substrate	substrate	NN
cord-022290-p0l1kv6n	332	42	(	(	-LRB-
cord-022290-p0l1kv6n	332	43	Webber	Webber	NNP
cord-022290-p0l1kv6n	332	44	et	et	NNP
cord-022290-p0l1kv6n	332	45	al	al	NNP
cord-022290-p0l1kv6n	332	46	.	.	NNP
cord-022290-p0l1kv6n	332	47	,	,	,
cord-022290-p0l1kv6n	332	48	1996	1996	CD
cord-022290-p0l1kv6n	332	49	)	)	-RRB-
cord-022290-p0l1kv6n	332	50	.	.	.
cord-022290-p0l1kv6n	333	1	While	while	IN
cord-022290-p0l1kv6n	333	2	the	the	DT
cord-022290-p0l1kv6n	333	3	details	detail	NNS
cord-022290-p0l1kv6n	333	4	of	of	IN
cord-022290-p0l1kv6n	333	5	the	the	DT
cord-022290-p0l1kv6n	333	6	specific	specific	JJ
cord-022290-p0l1kv6n	333	7	enzyme	enzyme	NN
cord-022290-p0l1kv6n	333	8	substrate	substrate	NN
cord-022290-p0l1kv6n	333	9	interactions	interaction	NNS
cord-022290-p0l1kv6n	333	10	gleaned	glean	VBN
cord-022290-p0l1kv6n	333	11	from	from	IN
cord-022290-p0l1kv6n	333	12	the	the	DT
cord-022290-p0l1kv6n	333	13	crystal	crystal	NN
cord-022290-p0l1kv6n	333	14	structures	structure	NNS
cord-022290-p0l1kv6n	333	15	of	of	IN
cord-022290-p0l1kv6n	333	16	3C	3C	NNP
cord-022290-p0l1kv6n	333	17	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	333	18	provide	provide	VBP
cord-022290-p0l1kv6n	333	19	valuable	valuable	JJ
cord-022290-p0l1kv6n	333	20	information	information	NN
cord-022290-p0l1kv6n	333	21	for	for	IN
cord-022290-p0l1kv6n	333	22	the	the	DT
cord-022290-p0l1kv6n	333	23	design	design	NN
cord-022290-p0l1kv6n	333	24	of	of	IN
cord-022290-p0l1kv6n	333	25	effective	effective	JJ
cord-022290-p0l1kv6n	333	26	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	333	27	,	,	,
cord-022290-p0l1kv6n	333	28	there	there	EX
cord-022290-p0l1kv6n	333	29	is	be	VBZ
cord-022290-p0l1kv6n	333	30	little	little	JJ
cord-022290-p0l1kv6n	333	31	experimental	experimental	JJ
cord-022290-p0l1kv6n	333	32	evidence	evidence	NN
cord-022290-p0l1kv6n	333	33	for	for	IN
cord-022290-p0l1kv6n	333	34	the	the	DT
cord-022290-p0l1kv6n	333	35	mechanism	mechanism	NN
cord-022290-p0l1kv6n	333	36	of	of	IN
cord-022290-p0l1kv6n	333	37	the	the	DT
cord-022290-p0l1kv6n	333	38	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	333	39	-	-	HYPH
cord-022290-p0l1kv6n	333	40	like	like	JJ
cord-022290-p0l1kv6n	333	41	cysteine	cysteine	NN
cord-022290-p0l1kv6n	333	42	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	333	43	.	.	.
cord-022290-p0l1kv6n	334	1	This	this	DT
cord-022290-p0l1kv6n	334	2	kind	kind	NN
cord-022290-p0l1kv6n	334	3	of	of	IN
cord-022290-p0l1kv6n	334	4	information	information	NN
cord-022290-p0l1kv6n	334	5	would	would	MD
cord-022290-p0l1kv6n	334	6	,	,	,
cord-022290-p0l1kv6n	334	7	however	however	RB
cord-022290-p0l1kv6n	334	8	,	,	,
cord-022290-p0l1kv6n	334	9	be	be	VB
cord-022290-p0l1kv6n	334	10	of	of	IN
cord-022290-p0l1kv6n	334	11	great	great	JJ
cord-022290-p0l1kv6n	334	12	value	value	NN
cord-022290-p0l1kv6n	334	13	in	in	IN
cord-022290-p0l1kv6n	334	14	identifying	identify	VBG
cord-022290-p0l1kv6n	334	15	potential	potential	JJ
cord-022290-p0l1kv6n	334	16	chemical	chemical	NN
cord-022290-p0l1kv6n	334	17	functionalities	functionality	NNS
cord-022290-p0l1kv6n	334	18	and	and	CC
cord-022290-p0l1kv6n	334	19	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	334	20	.	.	.
cord-022290-p0l1kv6n	335	1	The	the	DT
cord-022290-p0l1kv6n	335	2	primary	primary	JJ
cord-022290-p0l1kv6n	335	3	cleavage	cleavage	NN
cord-022290-p0l1kv6n	335	4	at	at	IN
cord-022290-p0l1kv6n	335	5	the	the	DT
cord-022290-p0l1kv6n	335	6	N	n	CD
cord-022290-p0l1kv6n	335	7	-	-	HYPH
cord-022290-p0l1kv6n	335	8	terminus	terminus	NN
cord-022290-p0l1kv6n	335	9	of	of	IN
cord-022290-p0l1kv6n	335	10	the	the	DT
cord-022290-p0l1kv6n	335	11	2A	2A	NNP
cord-022290-p0l1kv6n	335	12	gene	gene	NN
cord-022290-p0l1kv6n	335	13	product	product	NN
cord-022290-p0l1kv6n	335	14	that	that	WDT
cord-022290-p0l1kv6n	335	15	separates	separate	VBZ
cord-022290-p0l1kv6n	335	16	the	the	DT
cord-022290-p0l1kv6n	335	17	structural	structural	JJ
cord-022290-p0l1kv6n	335	18	and	and	CC
cord-022290-p0l1kv6n	335	19	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	335	20	proteins	protein	NNS
cord-022290-p0l1kv6n	335	21	in	in	IN
cord-022290-p0l1kv6n	335	22	the	the	DT
cord-022290-p0l1kv6n	335	23	entero	entero	NNP
cord-022290-p0l1kv6n	335	24	-	-	HYPH
cord-022290-p0l1kv6n	335	25	and	and	CC
cord-022290-p0l1kv6n	335	26	rhinoviruses	rhinovirus	NNS
cord-022290-p0l1kv6n	335	27	is	be	VBZ
cord-022290-p0l1kv6n	335	28	performed	perform	VBN
cord-022290-p0l1kv6n	335	29	by	by	IN
cord-022290-p0l1kv6n	335	30	the	the	DT
cord-022290-p0l1kv6n	335	31	2A	2A	NNP
cord-022290-p0l1kv6n	335	32	gene	gene	NN
cord-022290-p0l1kv6n	335	33	product	product	NN
cord-022290-p0l1kv6n	335	34	.	.	.
cord-022290-p0l1kv6n	336	1	Analysis	analysis	NN
cord-022290-p0l1kv6n	336	2	of	of	IN
cord-022290-p0l1kv6n	336	3	the	the	DT
cord-022290-p0l1kv6n	336	4	sequence	sequence	NN
cord-022290-p0l1kv6n	336	5	,	,	,
cord-022290-p0l1kv6n	336	6	mutational	mutational	JJ
cord-022290-p0l1kv6n	336	7	studies	study	NNS
cord-022290-p0l1kv6n	336	8	,	,	,
cord-022290-p0l1kv6n	336	9	and	and	CC
cord-022290-p0l1kv6n	336	10	model	model	NN
cord-022290-p0l1kv6n	336	11	-	-	HYPH
cord-022290-p0l1kv6n	336	12	building	building	NN
cord-022290-p0l1kv6n	336	13	studies	study	NNS
cord-022290-p0l1kv6n	336	14	have	have	VBP
cord-022290-p0l1kv6n	336	15	shown	show	VBN
cord-022290-p0l1kv6n	336	16	that	that	IN
cord-022290-p0l1kv6n	336	17	the	the	DT
cord-022290-p0l1kv6n	336	18	entero	entero	NNP
cord-022290-p0l1kv6n	336	19	-	-	HYPH
cord-022290-p0l1kv6n	336	20	and	and	CC
cord-022290-p0l1kv6n	336	21	rhinoviral	rhinoviral	NNP
cord-022290-p0l1kv6n	336	22	2A	2a	CD
cord-022290-p0l1kv6n	336	23	proteinase	proteinase	NN
cord-022290-p0l1kv6n	336	24	is	be	VBZ
cord-022290-p0l1kv6n	336	25	also	also	RB
cord-022290-p0l1kv6n	336	26	a	a	DT
cord-022290-p0l1kv6n	336	27	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	336	28	-	-	HYPH
cord-022290-p0l1kv6n	336	29	like	like	JJ
cord-022290-p0l1kv6n	336	30	cysteine	cysteine	NN
cord-022290-p0l1kv6n	336	31	proteinase	proteinase	NN
cord-022290-p0l1kv6n	336	32	but	but	CC
cord-022290-p0l1kv6n	336	33	distinct	distinct	JJ
cord-022290-p0l1kv6n	336	34	from	from	IN
cord-022290-p0l1kv6n	336	35	and	and	CC
cord-022290-p0l1kv6n	336	36	only	only	RB
cord-022290-p0l1kv6n	336	37	distantly	distantly	RB
cord-022290-p0l1kv6n	336	38	related	related	JJ
cord-022290-p0l1kv6n	336	39	to	to	IN
cord-022290-p0l1kv6n	336	40	3C.	3c.	CD
cord-022290-p0l1kv6n	337	1	The	the	DT
cord-022290-p0l1kv6n	337	2	2A	2a	CD
cord-022290-p0l1kv6n	337	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	337	4	is	be	VBZ
cord-022290-p0l1kv6n	337	5	a	a	DT
cord-022290-p0l1kv6n	337	6	smaller	small	JJR
cord-022290-p0l1kv6n	337	7	enzyme	enzyme	NN
cord-022290-p0l1kv6n	337	8	of	of	IN
cord-022290-p0l1kv6n	337	9	142	142	CD
cord-022290-p0l1kv6n	337	10	residues	residue	NNS
cord-022290-p0l1kv6n	337	11	.	.	.
cord-022290-p0l1kv6n	338	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	338	2	has	have	VBZ
cord-022290-p0l1kv6n	338	3	been	be	VBN
cord-022290-p0l1kv6n	338	4	suggested	suggest	VBN
cord-022290-p0l1kv6n	338	5	,	,	,
cord-022290-p0l1kv6n	338	6	based	base	VBN
cord-022290-p0l1kv6n	338	7	on	on	IN
cord-022290-p0l1kv6n	338	8	the	the	DT
cord-022290-p0l1kv6n	338	9	results	result	NNS
cord-022290-p0l1kv6n	338	10	of	of	IN
cord-022290-p0l1kv6n	338	11	mutational	mutational	JJ
cord-022290-p0l1kv6n	338	12	studies	study	NNS
cord-022290-p0l1kv6n	338	13	and	and	CC
cord-022290-p0l1kv6n	338	14	structural	structural	JJ
cord-022290-p0l1kv6n	338	15	models	model	NNS
cord-022290-p0l1kv6n	338	16	,	,	,
cord-022290-p0l1kv6n	338	17	that	that	IN
cord-022290-p0l1kv6n	338	18	the	the	DT
cord-022290-p0l1kv6n	338	19	active	active	JJ
cord-022290-p0l1kv6n	338	20	site	site	NN
cord-022290-p0l1kv6n	338	21	of	of	IN
cord-022290-p0l1kv6n	338	22	the	the	DT
cord-022290-p0l1kv6n	338	23	2A	2A	NNP
cord-022290-p0l1kv6n	338	24	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	338	25	contains	contain	VBZ
cord-022290-p0l1kv6n	338	26	a	a	DT
cord-022290-p0l1kv6n	338	27	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	338	28	triad	triad	NN
cord-022290-p0l1kv6n	338	29	of	of	IN
cord-022290-p0l1kv6n	338	30	Cysl06	Cysl06	NNP
cord-022290-p0l1kv6n	338	31	,	,	,
cord-022290-p0l1kv6n	338	32	His18	His18	NNP
cord-022290-p0l1kv6n	338	33	,	,	,
cord-022290-p0l1kv6n	338	34	and	and	CC
cord-022290-p0l1kv6n	338	35	Asp35	Asp35	NNP
cord-022290-p0l1kv6n	338	36	,	,	,
cord-022290-p0l1kv6n	338	37	which	which	WDT
cord-022290-p0l1kv6n	338	38	more	more	RBR
cord-022290-p0l1kv6n	338	39	closely	closely	RB
cord-022290-p0l1kv6n	338	40	resembles	resemble	VBZ
cord-022290-p0l1kv6n	338	41	that	that	DT
cord-022290-p0l1kv6n	338	42	of	of	IN
cord-022290-p0l1kv6n	338	43	the	the	DT
cord-022290-p0l1kv6n	338	44	serine	serine	NN
cord-022290-p0l1kv6n	338	45	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	338	46	(	(	-LRB-
cord-022290-p0l1kv6n	338	47	Sommergruber	Sommergruber	NNP
cord-022290-p0l1kv6n	338	48	et	et	FW
cord-022290-p0l1kv6n	338	49	al	al	NNP
cord-022290-p0l1kv6n	338	50	.	.	NNP
cord-022290-p0l1kv6n	338	51	,	,	,
cord-022290-p0l1kv6n	338	52	1989	1989	CD
cord-022290-p0l1kv6n	338	53	;	;	:
cord-022290-p0l1kv6n	339	1	Hellen	Hellen	NNP
cord-022290-p0l1kv6n	339	2	et	et	NNP
cord-022290-p0l1kv6n	339	3	al	al	NNP
cord-022290-p0l1kv6n	339	4	.	.	NNP
cord-022290-p0l1kv6n	339	5	,	,	,
cord-022290-p0l1kv6n	339	6	1991	1991	CD
cord-022290-p0l1kv6n	339	7	)	)	-RRB-
cord-022290-p0l1kv6n	339	8	.	.	.
cord-022290-p0l1kv6n	340	1	The	the	DT
cord-022290-p0l1kv6n	340	2	sequence	sequence	NN
cord-022290-p0l1kv6n	340	3	alignments	alignment	NNS
cord-022290-p0l1kv6n	340	4	also	also	RB
cord-022290-p0l1kv6n	340	5	seem	seem	VBP
cord-022290-p0l1kv6n	340	6	to	to	TO
cord-022290-p0l1kv6n	340	7	indicate	indicate	VB
cord-022290-p0l1kv6n	340	8	a	a	DT
cord-022290-p0l1kv6n	340	9	closer	close	JJR
cord-022290-p0l1kv6n	340	10	relationship	relationship	NN
cord-022290-p0l1kv6n	340	11	of	of	IN
cord-022290-p0l1kv6n	340	12	2A	2a	CD
cord-022290-p0l1kv6n	340	13	to	to	IN
cord-022290-p0l1kv6n	340	14	the	the	DT
cord-022290-p0l1kv6n	340	15	small	small	JJ
cord-022290-p0l1kv6n	340	16	,	,	,
cord-022290-p0l1kv6n	340	17	bacterial	bacterial	JJ
cord-022290-p0l1kv6n	340	18	serine	serine	NN
cord-022290-p0l1kv6n	340	19	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	340	20	(	(	-LRB-
cord-022290-p0l1kv6n	340	21	Sommergruber	Sommergruber	NNP
cord-022290-p0l1kv6n	340	22	et	et	FW
cord-022290-p0l1kv6n	340	23	al	al	NNP
cord-022290-p0l1kv6n	340	24	.	.	NNP
cord-022290-p0l1kv6n	340	25	,	,	,
cord-022290-p0l1kv6n	340	26	1997	1997	CD
cord-022290-p0l1kv6n	340	27	)	)	-RRB-
cord-022290-p0l1kv6n	340	28	.	.	.
cord-022290-p0l1kv6n	341	1	The	the	DT
cord-022290-p0l1kv6n	341	2	2A	2a	CD
cord-022290-p0l1kv6n	341	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	341	4	has	have	VBZ
cord-022290-p0l1kv6n	341	5	less	less	RBR
cord-022290-p0l1kv6n	341	6	stringent	stringent	JJ
cord-022290-p0l1kv6n	341	7	specificity	specificity	NN
cord-022290-p0l1kv6n	341	8	requirements	requirement	NNS
cord-022290-p0l1kv6n	341	9	than	than	IN
cord-022290-p0l1kv6n	341	10	the	the	DT
cord-022290-p0l1kv6n	341	11	3C	3C	NNP
cord-022290-p0l1kv6n	341	12	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	341	13	(	(	-LRB-
cord-022290-p0l1kv6n	341	14	Skern	Skern	NNP
cord-022290-p0l1kv6n	341	15	et	et	NNP
cord-022290-p0l1kv6n	341	16	al	al	NNP
cord-022290-p0l1kv6n	341	17	.	.	NNP
cord-022290-p0l1kv6n	341	18	,	,	,
cord-022290-p0l1kv6n	341	19	1991	1991	CD
cord-022290-p0l1kv6n	341	20	)	)	-RRB-
cord-022290-p0l1kv6n	341	21	.	.	.
cord-022290-p0l1kv6n	342	1	Presumably	presumably	RB
cord-022290-p0l1kv6n	342	2	this	this	DT
cord-022290-p0l1kv6n	342	3	reflects	reflect	VBZ
cord-022290-p0l1kv6n	342	4	the	the	DT
cord-022290-p0l1kv6n	342	5	fact	fact	NN
cord-022290-p0l1kv6n	342	6	that	that	IN
cord-022290-p0l1kv6n	342	7	its	-PRON-	PRP$
cord-022290-p0l1kv6n	342	8	major	major	JJ
cord-022290-p0l1kv6n	342	9	function	function	NN
cord-022290-p0l1kv6n	342	10	is	be	VBZ
cord-022290-p0l1kv6n	342	11	to	to	TO
cord-022290-p0l1kv6n	342	12	perform	perform	VB
cord-022290-p0l1kv6n	342	13	an	an	DT
cord-022290-p0l1kv6n	342	14	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	342	15	cleavage	cleavage	NN
cord-022290-p0l1kv6n	342	16	at	at	IN
cord-022290-p0l1kv6n	342	17	its	-PRON-	PRP$
cord-022290-p0l1kv6n	342	18	own	own	JJ
cord-022290-p0l1kv6n	342	19	N	n	CD
cord-022290-p0l1kv6n	342	20	-	-	HYPH
cord-022290-p0l1kv6n	342	21	terminus	terminus	NN
cord-022290-p0l1kv6n	342	22	.	.	.
cord-022290-p0l1kv6n	343	1	Indeed	indeed	RB
cord-022290-p0l1kv6n	343	2	,	,	,
cord-022290-p0l1kv6n	343	3	it	-PRON-	PRP
cord-022290-p0l1kv6n	343	4	has	have	VBZ
cord-022290-p0l1kv6n	343	5	been	be	VBN
cord-022290-p0l1kv6n	343	6	found	find	VBN
cord-022290-p0l1kv6n	343	7	that	that	IN
cord-022290-p0l1kv6n	343	8	amino	amino	NN
cord-022290-p0l1kv6n	343	9	acid	acid	NN
cord-022290-p0l1kv6n	343	10	changes	change	NNS
cord-022290-p0l1kv6n	343	11	in	in	IN
cord-022290-p0l1kv6n	343	12	a	a	DT
cord-022290-p0l1kv6n	343	13	substrate	substrate	NN
cord-022290-p0l1kv6n	343	14	affect	affect	VBP
cord-022290-p0l1kv6n	343	15	a	a	DT
cord-022290-p0l1kv6n	343	16	trans	trans	JJ
cord-022290-p0l1kv6n	343	17	activity	activity	NN
cord-022290-p0l1kv6n	343	18	but	but	CC
cord-022290-p0l1kv6n	343	19	not	not	RB
cord-022290-p0l1kv6n	343	20	the	the	DT
cord-022290-p0l1kv6n	343	21	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	343	22	cis	cis	NNP
cord-022290-p0l1kv6n	343	23	activity	activity	NN
cord-022290-p0l1kv6n	343	24	(	(	-LRB-
cord-022290-p0l1kv6n	343	25	Hellen	Hellen	NNP
cord-022290-p0l1kv6n	343	26	et	et	NNP
cord-022290-p0l1kv6n	343	27	al	al	NNP
cord-022290-p0l1kv6n	343	28	.	.	NNP
cord-022290-p0l1kv6n	343	29	,	,	,
cord-022290-p0l1kv6n	343	30	1992	1992	CD
cord-022290-p0l1kv6n	343	31	)	)	-RRB-
cord-022290-p0l1kv6n	343	32	.	.	.
cord-022290-p0l1kv6n	344	1	The	the	DT
cord-022290-p0l1kv6n	344	2	2A	2a	CD
cord-022290-p0l1kv6n	344	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	344	4	is	be	VBZ
cord-022290-p0l1kv6n	344	5	a	a	DT
cord-022290-p0l1kv6n	344	6	zinc	zinc	NN
cord-022290-p0l1kv6n	344	7	protein	protein	NN
cord-022290-p0l1kv6n	344	8	and	and	CC
cord-022290-p0l1kv6n	344	9	the	the	DT
cord-022290-p0l1kv6n	344	10	tightly	tightly	RB
cord-022290-p0l1kv6n	344	11	bound	bind	VBN
cord-022290-p0l1kv6n	344	12	zinc	zinc	NN
cord-022290-p0l1kv6n	344	13	ion	ion	NN
cord-022290-p0l1kv6n	344	14	presumably	presumably	RB
cord-022290-p0l1kv6n	344	15	plays	play	VBZ
cord-022290-p0l1kv6n	344	16	a	a	DT
cord-022290-p0l1kv6n	344	17	structural	structural	JJ
cord-022290-p0l1kv6n	344	18	role	role	NN
cord-022290-p0l1kv6n	344	19	(	(	-LRB-
cord-022290-p0l1kv6n	344	20	Sommergruber	Sommergruber	NNP
cord-022290-p0l1kv6n	344	21	et	et	FW
cord-022290-p0l1kv6n	344	22	al	al	NNP
cord-022290-p0l1kv6n	344	23	.	.	NNP
cord-022290-p0l1kv6n	344	24	,	,	,
cord-022290-p0l1kv6n	344	25	1994b	1994b	CD
cord-022290-p0l1kv6n	344	26	;	;	:
cord-022290-p0l1kv6n	344	27	Voss	Voss	NNP
cord-022290-p0l1kv6n	344	28	et	et	NNP
cord-022290-p0l1kv6n	344	29	al	al	NNP
cord-022290-p0l1kv6n	344	30	.	.	NNP
cord-022290-p0l1kv6n	344	31	,	,	,
cord-022290-p0l1kv6n	344	32	1995	1995	CD
cord-022290-p0l1kv6n	344	33	)	)	-RRB-
cord-022290-p0l1kv6n	344	34	.	.	.
cord-022290-p0l1kv6n	345	1	In	in	IN
cord-022290-p0l1kv6n	345	2	the	the	DT
cord-022290-p0l1kv6n	345	3	model	model	NN
cord-022290-p0l1kv6n	345	4	of	of	IN
cord-022290-p0l1kv6n	345	5	Sommergruber	Sommergruber	NNP
cord-022290-p0l1kv6n	345	6	et	et	NNP
cord-022290-p0l1kv6n	345	7	al	al	NNP
cord-022290-p0l1kv6n	345	8	.	.	.
cord-022290-p0l1kv6n	346	1	(	(	-LRB-
cord-022290-p0l1kv6n	346	2	1997	1997	CD
cord-022290-p0l1kv6n	346	3	)	)	-RRB-
cord-022290-p0l1kv6n	346	4	the	the	DT
cord-022290-p0l1kv6n	346	5	N	N	NNP
cord-022290-p0l1kv6n	346	6	-	-	HYPH
cord-022290-p0l1kv6n	346	7	terminal	terminal	NNP
cord-022290-p0l1kv6n	346	8	fl	fl	JJ
cord-022290-p0l1kv6n	346	9	-	-	HYPH
cord-022290-p0l1kv6n	346	10	barrel	barrel	NN
cord-022290-p0l1kv6n	346	11	has	have	VBZ
cord-022290-p0l1kv6n	346	12	fewer	few	JJR
cord-022290-p0l1kv6n	346	13	strands	strand	NNS
cord-022290-p0l1kv6n	346	14	and	and	CC
cord-022290-p0l1kv6n	346	15	presumably	presumably	RB
cord-022290-p0l1kv6n	346	16	the	the	DT
cord-022290-p0l1kv6n	346	17	zinc	zinc	NN
cord-022290-p0l1kv6n	346	18	ion	ion	NN
cord-022290-p0l1kv6n	346	19	is	be	VBZ
cord-022290-p0l1kv6n	346	20	therefore	therefore	RB
cord-022290-p0l1kv6n	346	21	needed	need	VBN
cord-022290-p0l1kv6n	346	22	to	to	TO
cord-022290-p0l1kv6n	346	23	stabilize	stabilize	VB
cord-022290-p0l1kv6n	346	24	the	the	DT
cord-022290-p0l1kv6n	346	25	N	n	CD
cord-022290-p0l1kv6n	346	26	-	-	HYPH
cord-022290-p0l1kv6n	346	27	terminal	terminal	NN
cord-022290-p0l1kv6n	346	28	domain	domain	NN
cord-022290-p0l1kv6n	346	29	of	of	IN
cord-022290-p0l1kv6n	346	30	the	the	DT
cord-022290-p0l1kv6n	346	31	small	small	JJ
cord-022290-p0l1kv6n	346	32	2A	2a	CD
cord-022290-p0l1kv6n	346	33	proteinase	proteinase	NN
cord-022290-p0l1kv6n	346	34	.	.	.
cord-022290-p0l1kv6n	347	1	A	a	DT
cord-022290-p0l1kv6n	347	2	second	second	JJ
cord-022290-p0l1kv6n	347	3	function	function	NN
cord-022290-p0l1kv6n	347	4	of	of	IN
cord-022290-p0l1kv6n	347	5	the	the	DT
cord-022290-p0l1kv6n	347	6	entero	entero	NNP
cord-022290-p0l1kv6n	347	7	-	-	HYPH
cord-022290-p0l1kv6n	347	8	and	and	CC
cord-022290-p0l1kv6n	347	9	rhinoviral	rhinoviral	NNP
cord-022290-p0l1kv6n	347	10	2A	2a	CD
cord-022290-p0l1kv6n	347	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	347	12	is	be	VBZ
cord-022290-p0l1kv6n	347	13	the	the	DT
cord-022290-p0l1kv6n	347	14	specific	specific	JJ
cord-022290-p0l1kv6n	347	15	cleavage	cleavage	NN
cord-022290-p0l1kv6n	347	16	of	of	IN
cord-022290-p0l1kv6n	347	17	one	one	CD
cord-022290-p0l1kv6n	347	18	of	of	IN
cord-022290-p0l1kv6n	347	19	the	the	DT
cord-022290-p0l1kv6n	347	20	proteins	protein	NNS
cord-022290-p0l1kv6n	347	21	of	of	IN
cord-022290-p0l1kv6n	347	22	the	the	DT
cord-022290-p0l1kv6n	347	23	eukaryotic	eukaryotic	JJ
cord-022290-p0l1kv6n	347	24	CAP	cap	NN
cord-022290-p0l1kv6n	347	25	-	-	HYPH
cord-022290-p0l1kv6n	347	26	binding	bind	VBG
cord-022290-p0l1kv6n	347	27	complex	complex	NN
cord-022290-p0l1kv6n	347	28	,	,	.
cord-022290-p0l1kv6n	348	1	eIF4	eif4	IN
cord-022290-p0l1kv6n	348	2	G	G	NNP
cord-022290-p0l1kv6n	348	3	(	(	-LRB-
cord-022290-p0l1kv6n	348	4	Sommergruber	Sommergruber	NNP
cord-022290-p0l1kv6n	348	5	et	et	FW
cord-022290-p0l1kv6n	348	6	al	al	NNP
cord-022290-p0l1kv6n	348	7	.	.	NNP
cord-022290-p0l1kv6n	348	8	,	,	,
cord-022290-p0l1kv6n	348	9	1994a	1994a	CD
cord-022290-p0l1kv6n	348	10	;	;	.
cord-022290-p0l1kv6n	349	1	Haghighat	Haghighat	NNP
cord-022290-p0l1kv6n	349	2	et	et	NNP
cord-022290-p0l1kv6n	349	3	al	al	NNP
cord-022290-p0l1kv6n	349	4	.	.	NNP
cord-022290-p0l1kv6n	349	5	,	,	,
cord-022290-p0l1kv6n	349	6	1996	1996	CD
cord-022290-p0l1kv6n	349	7	)	)	-RRB-
cord-022290-p0l1kv6n	349	8	.	.	.
cord-022290-p0l1kv6n	350	1	This	this	DT
cord-022290-p0l1kv6n	350	2	results	result	VBZ
cord-022290-p0l1kv6n	350	3	in	in	IN
cord-022290-p0l1kv6n	350	4	inhibition	inhibition	NN
cord-022290-p0l1kv6n	350	5	of	of	IN
cord-022290-p0l1kv6n	350	6	the	the	DT
cord-022290-p0l1kv6n	350	7	translation	translation	NN
cord-022290-p0l1kv6n	350	8	of	of	IN
cord-022290-p0l1kv6n	350	9	capped	cap	VBN
cord-022290-p0l1kv6n	350	10	,	,	,
cord-022290-p0l1kv6n	350	11	cellular	cellular	JJ
cord-022290-p0l1kv6n	350	12	mRNAs	mrna	NNS
cord-022290-p0l1kv6n	350	13	and	and	CC
cord-022290-p0l1kv6n	350	14	preferential	preferential	JJ
cord-022290-p0l1kv6n	350	15	translation	translation	NN
cord-022290-p0l1kv6n	350	16	of	of	IN
cord-022290-p0l1kv6n	350	17	the	the	DT
cord-022290-p0l1kv6n	350	18	viral	viral	JJ
cord-022290-p0l1kv6n	350	19	RNA	RNA	NNP
cord-022290-p0l1kv6n	350	20	.	.	.
cord-022290-p0l1kv6n	351	1	The	the	DT
cord-022290-p0l1kv6n	351	2	2A	2a	CD
cord-022290-p0l1kv6n	351	3	gene	gene	NN
cord-022290-p0l1kv6n	351	4	product	product	NN
cord-022290-p0l1kv6n	351	5	of	of	IN
cord-022290-p0l1kv6n	351	6	entero	entero	NNP
cord-022290-p0l1kv6n	351	7	-	-	:
cord-022290-p0l1kv6n	351	8	and	and	CC
cord-022290-p0l1kv6n	351	9	rhinoviruses	rhinovirus	NNS
cord-022290-p0l1kv6n	351	10	also	also	RB
cord-022290-p0l1kv6n	351	11	has	have	VBZ
cord-022290-p0l1kv6n	351	12	functions	function	NNS
cord-022290-p0l1kv6n	351	13	in	in	IN
cord-022290-p0l1kv6n	351	14	addition	addition	NN
cord-022290-p0l1kv6n	351	15	to	to	IN
cord-022290-p0l1kv6n	351	16	its	-PRON-	PRP$
cord-022290-p0l1kv6n	351	17	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	351	18	activity	activity	NN
cord-022290-p0l1kv6n	351	19	(	(	-LRB-
cord-022290-p0l1kv6n	351	20	Belsham	Belsham	NNP
cord-022290-p0l1kv6n	351	21	and	and	CC
cord-022290-p0l1kv6n	351	22	Sonnenberg	Sonnenberg	NNP
cord-022290-p0l1kv6n	351	23	,	,	,
cord-022290-p0l1kv6n	351	24	1996	1996	CD
cord-022290-p0l1kv6n	351	25	)	)	-RRB-
cord-022290-p0l1kv6n	351	26	.	.	.
cord-022290-p0l1kv6n	352	1	There	there	EX
cord-022290-p0l1kv6n	352	2	is	be	VBZ
cord-022290-p0l1kv6n	352	3	evidence	evidence	NN
cord-022290-p0l1kv6n	352	4	that	that	IN
cord-022290-p0l1kv6n	352	5	2A	2a	CD
cord-022290-p0l1kv6n	352	6	forms	form	VBZ
cord-022290-p0l1kv6n	352	7	a	a	DT
cord-022290-p0l1kv6n	352	8	complex	complex	NN
cord-022290-p0l1kv6n	352	9	with	with	IN
cord-022290-p0l1kv6n	352	10	other	other	JJ
cord-022290-p0l1kv6n	352	11	viral	viral	JJ
cord-022290-p0l1kv6n	352	12	proteins	protein	NNS
cord-022290-p0l1kv6n	352	13	and	and	CC
cord-022290-p0l1kv6n	352	14	is	be	VBZ
cord-022290-p0l1kv6n	352	15	involved	involve	VBN
cord-022290-p0l1kv6n	352	16	in	in	IN
cord-022290-p0l1kv6n	352	17	viral	viral	JJ
cord-022290-p0l1kv6n	352	18	RNA	RNA	NNP
cord-022290-p0l1kv6n	352	19	translation	translation	NN
cord-022290-p0l1kv6n	352	20	and	and	CC
cord-022290-p0l1kv6n	352	21	other	other	JJ
cord-022290-p0l1kv6n	352	22	aspects	aspect	NNS
cord-022290-p0l1kv6n	352	23	of	of	IN
cord-022290-p0l1kv6n	352	24	viral	viral	JJ
cord-022290-p0l1kv6n	352	25	replication	replication	NN
cord-022290-p0l1kv6n	352	26	(	(	-LRB-
cord-022290-p0l1kv6n	353	1	Molla	Molla	NNP
cord-022290-p0l1kv6n	353	2	et	et	NNP
cord-022290-p0l1kv6n	353	3	al	al	NNP
cord-022290-p0l1kv6n	353	4	.	.	.
cord-022290-p0l1kv6n	354	1	,	,	,
cord-022290-p0l1kv6n	354	2	1993	1993	CD
cord-022290-p0l1kv6n	354	3	;	;	:
cord-022290-p0l1kv6n	354	4	Lu	Lu	NNP
cord-022290-p0l1kv6n	354	5	et	et	FW
cord-022290-p0l1kv6n	354	6	al	al	NNP
cord-022290-p0l1kv6n	354	7	.	.	.
cord-022290-p0l1kv6n	355	1	,	,	,
cord-022290-p0l1kv6n	355	2	1995	1995	CD
cord-022290-p0l1kv6n	355	3	;	;	:
cord-022290-p0l1kv6n	355	4	Cuconati	Cuconati	NNP
cord-022290-p0l1kv6n	355	5	et	et	NNP
cord-022290-p0l1kv6n	355	6	al	al	NNP
cord-022290-p0l1kv6n	355	7	.	.	NNP
cord-022290-p0l1kv6n	355	8	,	,	,
cord-022290-p0l1kv6n	355	9	1998	1998	CD
cord-022290-p0l1kv6n	355	10	)	)	-RRB-
cord-022290-p0l1kv6n	355	11	.	.	.
cord-022290-p0l1kv6n	356	1	There	there	EX
cord-022290-p0l1kv6n	356	2	is	be	VBZ
cord-022290-p0l1kv6n	356	3	little	little	JJ
cord-022290-p0l1kv6n	356	4	experimental	experimental	JJ
cord-022290-p0l1kv6n	356	5	evidence	evidence	NN
cord-022290-p0l1kv6n	356	6	for	for	IN
cord-022290-p0l1kv6n	356	7	the	the	DT
cord-022290-p0l1kv6n	356	8	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	356	9	mechanism	mechanism	NN
cord-022290-p0l1kv6n	356	10	of	of	IN
cord-022290-p0l1kv6n	356	11	the	the	DT
cord-022290-p0l1kv6n	356	12	2A	2a	CD
cord-022290-p0l1kv6n	356	13	proteinase	proteinase	NN
cord-022290-p0l1kv6n	356	14	.	.	.
cord-022290-p0l1kv6n	357	1	The	the	DT
cord-022290-p0l1kv6n	357	2	chemical	chemical	NN
cord-022290-p0l1kv6n	357	3	functionalities	functionality	NNS
cord-022290-p0l1kv6n	357	4	which	which	WDT
cord-022290-p0l1kv6n	357	5	provide	provide	VBP
cord-022290-p0l1kv6n	357	6	good	good	JJ
cord-022290-p0l1kv6n	357	7	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	357	8	of	of	IN
cord-022290-p0l1kv6n	357	9	the	the	DT
cord-022290-p0l1kv6n	357	10	3C	3C	NNP
cord-022290-p0l1kv6n	357	11	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	357	12	,	,	,
cord-022290-p0l1kv6n	357	13	such	such	JJ
cord-022290-p0l1kv6n	357	14	as	as	IN
cord-022290-p0l1kv6n	357	15	the	the	DT
cord-022290-p0l1kv6n	357	16	fluoromethylketones	fluoromethylketone	NNS
cord-022290-p0l1kv6n	357	17	,	,	,
cord-022290-p0l1kv6n	357	18	are	be	VBP
cord-022290-p0l1kv6n	357	19	also	also	RB
cord-022290-p0l1kv6n	357	20	effective	effective	JJ
cord-022290-p0l1kv6n	357	21	against	against	IN
cord-022290-p0l1kv6n	357	22	other	other	JJ
cord-022290-p0l1kv6n	357	23	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	357	24	-	-	HYPH
cord-022290-p0l1kv6n	357	25	like	like	JJ
cord-022290-p0l1kv6n	357	26	cysteine	cysteine	NN
cord-022290-p0l1kv6n	357	27	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	357	28	.	.	.
cord-022290-p0l1kv6n	358	1	Because	because	IN
cord-022290-p0l1kv6n	358	2	the	the	DT
cord-022290-p0l1kv6n	358	3	specificity	specificity	NN
cord-022290-p0l1kv6n	358	4	requirements	requirement	NNS
cord-022290-p0l1kv6n	358	5	of	of	IN
cord-022290-p0l1kv6n	358	6	the	the	DT
cord-022290-p0l1kv6n	358	7	2A	2A	NNP
cord-022290-p0l1kv6n	358	8	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	358	9	are	be	VBP
cord-022290-p0l1kv6n	358	10	less	less	RBR
cord-022290-p0l1kv6n	358	11	stringent	stringent	JJ
cord-022290-p0l1kv6n	358	12	,	,	,
cord-022290-p0l1kv6n	358	13	the	the	DT
cord-022290-p0l1kv6n	358	14	design	design	NN
cord-022290-p0l1kv6n	358	15	of	of	IN
cord-022290-p0l1kv6n	358	16	specific	specific	JJ
cord-022290-p0l1kv6n	358	17	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	358	18	against	against	IN
cord-022290-p0l1kv6n	358	19	this	this	DT
cord-022290-p0l1kv6n	358	20	class	class	NN
cord-022290-p0l1kv6n	358	21	of	of	IN
cord-022290-p0l1kv6n	358	22	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	358	23	could	could	MD
cord-022290-p0l1kv6n	358	24	be	be	VB
cord-022290-p0l1kv6n	358	25	more	more	RBR
cord-022290-p0l1kv6n	358	26	difficult	difficult	JJ
cord-022290-p0l1kv6n	358	27	.	.	.
cord-022290-p0l1kv6n	359	1	The	the	DT
cord-022290-p0l1kv6n	359	2	aphthoviruses	aphthoviruse	NNS
cord-022290-p0l1kv6n	359	3	have	have	VBP
cord-022290-p0l1kv6n	359	4	another	another	DT
cord-022290-p0l1kv6n	359	5	distinct	distinct	JJ
cord-022290-p0l1kv6n	359	6	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	359	7	activity	activity	NN
cord-022290-p0l1kv6n	359	8	besides	besides	IN
cord-022290-p0l1kv6n	359	9	the	the	DT
cord-022290-p0l1kv6n	359	10	3C	3C	NNP
cord-022290-p0l1kv6n	359	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	359	12	.	.	.
cord-022290-p0l1kv6n	360	1	The	the	DT
cord-022290-p0l1kv6n	360	2	gene	gene	NN
cord-022290-p0l1kv6n	360	3	coding	code	VBG
cord-022290-p0l1kv6n	360	4	for	for	IN
cord-022290-p0l1kv6n	360	5	the	the	DT
cord-022290-p0l1kv6n	360	6	L	L	NNP
cord-022290-p0l1kv6n	360	7	proteinase	proteinase	NN
cord-022290-p0l1kv6n	360	8	is	be	VBZ
cord-022290-p0l1kv6n	360	9	located	locate	VBN
cord-022290-p0l1kv6n	360	10	at	at	IN
cord-022290-p0l1kv6n	360	11	the	the	DT
cord-022290-p0l1kv6n	360	12	N	n	CD
cord-022290-p0l1kv6n	360	13	-	-	HYPH
cord-022290-p0l1kv6n	360	14	terminus	terminus	NN
cord-022290-p0l1kv6n	360	15	of	of	IN
cord-022290-p0l1kv6n	360	16	the	the	DT
cord-022290-p0l1kv6n	360	17	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	360	18	and	and	CC
cord-022290-p0l1kv6n	360	19	precedes	precede	VBZ
cord-022290-p0l1kv6n	360	20	the	the	DT
cord-022290-p0l1kv6n	360	21	structural	structural	JJ
cord-022290-p0l1kv6n	360	22	proteins	protein	NNS
cord-022290-p0l1kv6n	360	23	.	.	.
cord-022290-p0l1kv6n	361	1	The	the	DT
cord-022290-p0l1kv6n	361	2	L	L	NNP
cord-022290-p0l1kv6n	361	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	361	4	cleaves	cleave	VBZ
cord-022290-p0l1kv6n	361	5	its	-PRON-	PRP$
cord-022290-p0l1kv6n	361	6	own	own	JJ
cord-022290-p0l1kv6n	361	7	C	c	NN
cord-022290-p0l1kv6n	361	8	-	-	HYPH
cord-022290-p0l1kv6n	361	9	terminus	terminus	NN
cord-022290-p0l1kv6n	361	10	(	(	-LRB-
cord-022290-p0l1kv6n	361	11	Strebel	Strebel	NNP
cord-022290-p0l1kv6n	361	12	and	and	CC
cord-022290-p0l1kv6n	361	13	Beck	Beck	NNP
cord-022290-p0l1kv6n	361	14	,	,	,
cord-022290-p0l1kv6n	361	15	1986	1986	CD
cord-022290-p0l1kv6n	361	16	)	)	-RRB-
cord-022290-p0l1kv6n	361	17	.	.	.
cord-022290-p0l1kv6n	362	1	In	in	IN
cord-022290-p0l1kv6n	362	2	vitro	vitro	FW
cord-022290-p0l1kv6n	362	3	this	this	DT
cord-022290-p0l1kv6n	362	4	cleavage	cleavage	NN
cord-022290-p0l1kv6n	362	5	can	can	MD
cord-022290-p0l1kv6n	362	6	occur	occur	VB
cord-022290-p0l1kv6n	362	7	in	in	IN
cord-022290-p0l1kv6n	362	8	cis	cis	NNP
cord-022290-p0l1kv6n	362	9	and	and	CC
cord-022290-p0l1kv6n	362	10	trans	trans	NNP
cord-022290-p0l1kv6n	363	1	(	(	-LRB-
cord-022290-p0l1kv6n	363	2	Medina	Medina	NNP
cord-022290-p0l1kv6n	363	3	et	et	NNP
cord-022290-p0l1kv6n	363	4	al	al	NNP
cord-022290-p0l1kv6n	363	5	.	.	NNP
cord-022290-p0l1kv6n	363	6	,	,	,
cord-022290-p0l1kv6n	363	7	1993	1993	CD
cord-022290-p0l1kv6n	363	8	;	;	:
cord-022290-p0l1kv6n	363	9	Cao	Cao	NNP
cord-022290-p0l1kv6n	363	10	et	et	NNP
cord-022290-p0l1kv6n	363	11	al	al	NNP
cord-022290-p0l1kv6n	363	12	.	.	NNP
cord-022290-p0l1kv6n	363	13	,	,	,
cord-022290-p0l1kv6n	363	14	1995	1995	CD
cord-022290-p0l1kv6n	363	15	)	)	-RRB-
cord-022290-p0l1kv6n	363	16	.	.	.
cord-022290-p0l1kv6n	364	1	The	the	DT
cord-022290-p0l1kv6n	364	2	aphthoviral	aphthoviral	NNP
cord-022290-p0l1kv6n	364	3	L	l	NN
cord-022290-p0l1kv6n	364	4	proteinase	proteinase	NN
cord-022290-p0l1kv6n	364	5	also	also	RB
cord-022290-p0l1kv6n	364	6	cleaves	cleave	VBZ
cord-022290-p0l1kv6n	364	7	the	the	DT
cord-022290-p0l1kv6n	364	8	cellular	cellular	NN
cord-022290-p0l1kv6n	364	9	eIF4	eif4	IN
cord-022290-p0l1kv6n	364	10	G	G	NNP
cord-022290-p0l1kv6n	364	11	and	and	CC
cord-022290-p0l1kv6n	364	12	thus	thus	RB
cord-022290-p0l1kv6n	364	13	causes	cause	VBZ
cord-022290-p0l1kv6n	364	14	inhibition	inhibition	NN
cord-022290-p0l1kv6n	364	15	of	of	IN
cord-022290-p0l1kv6n	364	16	the	the	DT
cord-022290-p0l1kv6n	364	17	translation	translation	NN
cord-022290-p0l1kv6n	364	18	of	of	IN
cord-022290-p0l1kv6n	364	19	capped	cap	VBN
cord-022290-p0l1kv6n	364	20	,	,	,
cord-022290-p0l1kv6n	364	21	cellular	cellular	JJ
cord-022290-p0l1kv6n	364	22	mRNAs	mrnas	CD
cord-022290-p0l1kv6n	364	23	.	.	.
cord-022290-p0l1kv6n	365	1	This	this	DT
cord-022290-p0l1kv6n	365	2	function	function	NN
cord-022290-p0l1kv6n	365	3	of	of	IN
cord-022290-p0l1kv6n	365	4	the	the	DT
cord-022290-p0l1kv6n	365	5	aphthoviral	aphthoviral	NNP
cord-022290-p0l1kv6n	365	6	L	L	NNP
cord-022290-p0l1kv6n	365	7	proteinase	proteinase	NN
cord-022290-p0l1kv6n	365	8	is	be	VBZ
cord-022290-p0l1kv6n	365	9	similar	similar	JJ
cord-022290-p0l1kv6n	365	10	to	to	IN
cord-022290-p0l1kv6n	365	11	the	the	DT
cord-022290-p0l1kv6n	365	12	one	one	NN
cord-022290-p0l1kv6n	365	13	performed	perform	VBN
cord-022290-p0l1kv6n	365	14	by	by	IN
cord-022290-p0l1kv6n	365	15	the	the	DT
cord-022290-p0l1kv6n	365	16	entero	entero	NNP
cord-022290-p0l1kv6n	365	17	-	-	HYPH
cord-022290-p0l1kv6n	365	18	and	and	CC
cord-022290-p0l1kv6n	365	19	rhinoviral	rhinoviral	NNP
cord-022290-p0l1kv6n	365	20	2A	2A	NNP
cord-022290-p0l1kv6n	365	21	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	365	22	.	.	.
cord-022290-p0l1kv6n	366	1	However	however	RB
cord-022290-p0l1kv6n	366	2	,	,	,
cord-022290-p0l1kv6n	366	3	the	the	DT
cord-022290-p0l1kv6n	366	4	cleavage	cleavage	NN
cord-022290-p0l1kv6n	366	5	of	of	IN
cord-022290-p0l1kv6n	366	6	eIF4	eIF4	NNP
cord-022290-p0l1kv6n	366	7	G	G	NNP
cord-022290-p0l1kv6n	366	8	by	by	IN
cord-022290-p0l1kv6n	366	9	the	the	DT
cord-022290-p0l1kv6n	366	10	L	l	NN
cord-022290-p0l1kv6n	366	11	proteinase	proteinase	NN
cord-022290-p0l1kv6n	366	12	occurs	occur	VBZ
cord-022290-p0l1kv6n	366	13	in	in	IN
cord-022290-p0l1kv6n	366	14	a	a	DT
cord-022290-p0l1kv6n	366	15	different	different	JJ
cord-022290-p0l1kv6n	366	16	position	position	NN
cord-022290-p0l1kv6n	366	17	(	(	-LRB-
cord-022290-p0l1kv6n	366	18	Kirchweger	Kirchweger	NNP
cord-022290-p0l1kv6n	366	19	et	et	NNP
cord-022290-p0l1kv6n	366	20	al	al	NNP
cord-022290-p0l1kv6n	366	21	.	.	NNP
cord-022290-p0l1kv6n	366	22	,	,	,
cord-022290-p0l1kv6n	366	23	1994	1994	CD
cord-022290-p0l1kv6n	366	24	)	)	-RRB-
cord-022290-p0l1kv6n	366	25	.	.	.
cord-022290-p0l1kv6n	367	1	In	in	IN
cord-022290-p0l1kv6n	367	2	spite	spite	NN
cord-022290-p0l1kv6n	367	3	of	of	IN
cord-022290-p0l1kv6n	367	4	these	these	DT
cord-022290-p0l1kv6n	367	5	functions	function	NNS
cord-022290-p0l1kv6n	367	6	the	the	DT
cord-022290-p0l1kv6n	367	7	L	L	NNP
cord-022290-p0l1kv6n	367	8	proteinase	proteinase	NN
cord-022290-p0l1kv6n	367	9	is	be	VBZ
cord-022290-p0l1kv6n	367	10	not	not	RB
cord-022290-p0l1kv6n	367	11	essential	essential	JJ
cord-022290-p0l1kv6n	367	12	for	for	IN
cord-022290-p0l1kv6n	367	13	the	the	DT
cord-022290-p0l1kv6n	367	14	replication	replication	NN
cord-022290-p0l1kv6n	367	15	of	of	IN
cord-022290-p0l1kv6n	367	16	the	the	DT
cord-022290-p0l1kv6n	367	17	virus	virus	NN
cord-022290-p0l1kv6n	368	1	(	(	-LRB-
cord-022290-p0l1kv6n	368	2	Piccone	Piccone	NNP
cord-022290-p0l1kv6n	368	3	et	et	NNP
cord-022290-p0l1kv6n	368	4	al	al	NNP
cord-022290-p0l1kv6n	368	5	.	.	NNP
cord-022290-p0l1kv6n	368	6	,	,	,
cord-022290-p0l1kv6n	368	7	1995a	1995a	CD
cord-022290-p0l1kv6n	368	8	)	)	-RRB-
cord-022290-p0l1kv6n	368	9	.	.	.
cord-022290-p0l1kv6n	369	1	The	the	DT
cord-022290-p0l1kv6n	369	2	L	L	NNP
cord-022290-p0l1kv6n	369	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	369	4	is	be	VBZ
cord-022290-p0l1kv6n	369	5	a	a	DT
cord-022290-p0l1kv6n	369	6	cysteine	cysteine	NN
cord-022290-p0l1kv6n	369	7	proteinase	proteinase	NN
cord-022290-p0l1kv6n	369	8	and	and	CC
cord-022290-p0l1kv6n	369	9	analysis	analysis	NN
cord-022290-p0l1kv6n	369	10	of	of	IN
cord-022290-p0l1kv6n	369	11	the	the	DT
cord-022290-p0l1kv6n	369	12	sequence	sequence	NN
cord-022290-p0l1kv6n	369	13	suggests	suggest	VBZ
cord-022290-p0l1kv6n	369	14	that	that	IN
cord-022290-p0l1kv6n	369	15	it	-PRON-	PRP
cord-022290-p0l1kv6n	369	16	belongs	belong	VBZ
cord-022290-p0l1kv6n	369	17	to	to	IN
cord-022290-p0l1kv6n	369	18	the	the	DT
cord-022290-p0l1kv6n	369	19	family	family	NN
cord-022290-p0l1kv6n	369	20	of	of	IN
cord-022290-p0l1kv6n	369	21	papain	papain	NN
cord-022290-p0l1kv6n	369	22	-	-	HYPH
cord-022290-p0l1kv6n	369	23	like	like	IN
cord-022290-p0l1kv6n	369	24	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	369	25	(	(	-LRB-
cord-022290-p0l1kv6n	369	26	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	369	27	et	et	NNP
cord-022290-p0l1kv6n	369	28	al	al	NNP
cord-022290-p0l1kv6n	369	29	.	.	NNP
cord-022290-p0l1kv6n	369	30	,	,	,
cord-022290-p0l1kv6n	369	31	1991	1991	CD
cord-022290-p0l1kv6n	369	32	)	)	-RRB-
cord-022290-p0l1kv6n	369	33	.	.	.
cord-022290-p0l1kv6n	370	1	The	the	DT
cord-022290-p0l1kv6n	370	2	enzyme	enzyme	NN
cord-022290-p0l1kv6n	370	3	is	be	VBZ
cord-022290-p0l1kv6n	370	4	present	present	JJ
cord-022290-p0l1kv6n	370	5	in	in	IN
cord-022290-p0l1kv6n	370	6	two	two	CD
cord-022290-p0l1kv6n	370	7	forms	form	NNS
cord-022290-p0l1kv6n	370	8	which	which	WDT
cord-022290-p0l1kv6n	370	9	differ	differ	VBP
cord-022290-p0l1kv6n	370	10	by	by	IN
cord-022290-p0l1kv6n	370	11	size	size	NN
cord-022290-p0l1kv6n	370	12	and	and	CC
cord-022290-p0l1kv6n	370	13	originate	originate	VBP
cord-022290-p0l1kv6n	370	14	from	from	IN
cord-022290-p0l1kv6n	370	15	two	two	CD
cord-022290-p0l1kv6n	370	16	different	different	JJ
cord-022290-p0l1kv6n	370	17	initiation	initiation	NN
cord-022290-p0l1kv6n	370	18	codons	codon	NNS
cord-022290-p0l1kv6n	370	19	in	in	IN
cord-022290-p0l1kv6n	370	20	the	the	DT
cord-022290-p0l1kv6n	370	21	viral	viral	JJ
cord-022290-p0l1kv6n	370	22	genome	genome	NN
cord-022290-p0l1kv6n	370	23	.	.	.
cord-022290-p0l1kv6n	371	1	The	the	DT
cord-022290-p0l1kv6n	371	2	Lb	Lb	NNP
cord-022290-p0l1kv6n	371	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	371	4	of	of	IN
cord-022290-p0l1kv6n	371	5	foot	foot	NN
cord-022290-p0l1kv6n	371	6	-	-	HYPH
cord-022290-p0l1kv6n	371	7	and	and	CC
cord-022290-p0l1kv6n	371	8	-	-	HYPH
cord-022290-p0l1kv6n	371	9	mouth	mouth	NN
cord-022290-p0l1kv6n	371	10	disease	disease	NN
cord-022290-p0l1kv6n	371	11	virus	virus	NN
cord-022290-p0l1kv6n	371	12	(	(	-LRB-
cord-022290-p0l1kv6n	371	13	FMDV	FMDV	NNP
cord-022290-p0l1kv6n	371	14	)	)	-RRB-
cord-022290-p0l1kv6n	371	15	consists	consist	VBZ
cord-022290-p0l1kv6n	371	16	of	of	IN
cord-022290-p0l1kv6n	371	17	173	173	CD
cord-022290-p0l1kv6n	371	18	residues	residue	NNS
cord-022290-p0l1kv6n	371	19	and	and	CC
cord-022290-p0l1kv6n	371	20	the	the	DT
cord-022290-p0l1kv6n	371	21	Lab	lab	NN
cord-022290-p0l1kv6n	371	22	proteinase	proteinase	NN
cord-022290-p0l1kv6n	371	23	is	be	VBZ
cord-022290-p0l1kv6n	371	24	28	28	CD
cord-022290-p0l1kv6n	371	25	residues	residue	NNS
cord-022290-p0l1kv6n	371	26	longer	long	RBR
cord-022290-p0l1kv6n	371	27	.	.	.
cord-022290-p0l1kv6n	372	1	Sequence	sequence	NN
cord-022290-p0l1kv6n	372	2	analysis	analysis	NN
cord-022290-p0l1kv6n	372	3	,	,	,
cord-022290-p0l1kv6n	372	4	site	site	NN
cord-022290-p0l1kv6n	372	5	-	-	HYPH
cord-022290-p0l1kv6n	372	6	directed	direct	VBN
cord-022290-p0l1kv6n	372	7	mutagenesis	mutagenesis	NN
cord-022290-p0l1kv6n	372	8	,	,	,
cord-022290-p0l1kv6n	372	9	and	and	CC
cord-022290-p0l1kv6n	372	10	modeling	modeling	NN
cord-022290-p0l1kv6n	372	11	studies	study	NNS
cord-022290-p0l1kv6n	372	12	identified	identify	VBD
cord-022290-p0l1kv6n	372	13	the	the	DT
cord-022290-p0l1kv6n	372	14	nucleophile	nucleophile	NN
cord-022290-p0l1kv6n	372	15	,	,	,
cord-022290-p0l1kv6n	372	16	the	the	DT
cord-022290-p0l1kv6n	372	17	general	general	JJ
cord-022290-p0l1kv6n	372	18	acid	acid	NN
cord-022290-p0l1kv6n	372	19	-	-	HYPH
cord-022290-p0l1kv6n	372	20	base	base	NN
cord-022290-p0l1kv6n	372	21	catalyst	catalyst	NN
cord-022290-p0l1kv6n	372	22	,	,	,
cord-022290-p0l1kv6n	372	23	and	and	CC
cord-022290-p0l1kv6n	372	24	the	the	DT
cord-022290-p0l1kv6n	372	25	third	third	JJ
cord-022290-p0l1kv6n	372	26	member	member	NN
cord-022290-p0l1kv6n	372	27	of	of	IN
cord-022290-p0l1kv6n	372	28	the	the	DT
cord-022290-p0l1kv6n	372	29	catalytic	catalytic	JJ
cord-022290-p0l1kv6n	372	30	triad	triad	NN
cord-022290-p0l1kv6n	372	31	as	as	IN
cord-022290-p0l1kv6n	372	32	Cys51	Cys51	NNP
cord-022290-p0l1kv6n	372	33	,	,	,
cord-022290-p0l1kv6n	372	34	His148	his148	CD
cord-022290-p0l1kv6n	372	35	,	,	,
cord-022290-p0l1kv6n	372	36	and	and	CC
cord-022290-p0l1kv6n	372	37	Asp	Asp	NNP
cord-022290-p0l1kv6n	372	38	164	164	CD
cord-022290-p0l1kv6n	372	39	,	,	,
cord-022290-p0l1kv6n	372	40	respectively	respectively	RB
cord-022290-p0l1kv6n	372	41	(	(	-LRB-
cord-022290-p0l1kv6n	372	42	Gorbalenya	Gorbalenya	NNP
cord-022290-p0l1kv6n	372	43	et	et	NNP
cord-022290-p0l1kv6n	372	44	al	al	NNP
cord-022290-p0l1kv6n	372	45	.	.	NNP
cord-022290-p0l1kv6n	372	46	,	,	,
cord-022290-p0l1kv6n	372	47	1991	1991	CD
cord-022290-p0l1kv6n	373	1	;	;	:
cord-022290-p0l1kv6n	373	2	Piccone	Piccone	NNP
cord-022290-p0l1kv6n	373	3	et	et	NNP
cord-022290-p0l1kv6n	373	4	al	al	NNP
cord-022290-p0l1kv6n	373	5	.	.	.
cord-022290-p0l1kv6n	374	1	,	,	,
cord-022290-p0l1kv6n	374	2	1995b	1995b	CD
cord-022290-p0l1kv6n	374	3	;	;	:
cord-022290-p0l1kv6n	374	4	Roberts	Roberts	NNP
cord-022290-p0l1kv6n	374	5	and	and	CC
cord-022290-p0l1kv6n	374	6	Belsham	Belsham	NNP
cord-022290-p0l1kv6n	374	7	,	,	,
cord-022290-p0l1kv6n	374	8	1995	1995	CD
cord-022290-p0l1kv6n	374	9	;	;	:
cord-022290-p0l1kv6n	374	10	Skern	Skern	NNP
cord-022290-p0l1kv6n	374	11	et	et	NNP
cord-022290-p0l1kv6n	374	12	al	al	NNP
cord-022290-p0l1kv6n	374	13	.	.	NNP
cord-022290-p0l1kv6n	374	14	,	,	,
cord-022290-p0l1kv6n	374	15	1998	1998	CD
cord-022290-p0l1kv6n	374	16	)	)	-RRB-
cord-022290-p0l1kv6n	374	17	.	.	.
cord-022290-p0l1kv6n	375	1	Sequence	sequence	NN
cord-022290-p0l1kv6n	375	2	alignments	alignment	NNS
cord-022290-p0l1kv6n	375	3	also	also	RB
cord-022290-p0l1kv6n	375	4	suggest	suggest	VBP
cord-022290-p0l1kv6n	375	5	that	that	IN
cord-022290-p0l1kv6n	375	6	the	the	DT
cord-022290-p0l1kv6n	375	7	side	side	NN
cord-022290-p0l1kv6n	375	8	-	-	HYPH
cord-022290-p0l1kv6n	375	9	chain	chain	NN
cord-022290-p0l1kv6n	375	10	of	of	IN
cord-022290-p0l1kv6n	375	11	Asn46	Asn46	NNP
cord-022290-p0l1kv6n	375	12	contributes	contribute	VBZ
cord-022290-p0l1kv6n	375	13	to	to	IN
cord-022290-p0l1kv6n	375	14	the	the	DT
cord-022290-p0l1kv6n	375	15	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	375	16	hole	hole	NN
cord-022290-p0l1kv6n	375	17	(	(	-LRB-
cord-022290-p0l1kv6n	375	18	similar	similar	JJ
cord-022290-p0l1kv6n	375	19	to	to	IN
cord-022290-p0l1kv6n	375	20	Gln	Gln	NNP
cord-022290-p0l1kv6n	375	21	19	19	CD
cord-022290-p0l1kv6n	375	22	of	of	IN
cord-022290-p0l1kv6n	375	23	papain	papain	NN
cord-022290-p0l1kv6n	375	24	)	)	-RRB-
cord-022290-p0l1kv6n	375	25	.	.	.
cord-022290-p0l1kv6n	376	1	The	the	DT
cord-022290-p0l1kv6n	376	2	C	c	NN
cord-022290-p0l1kv6n	376	3	-	-	HYPH
cord-022290-p0l1kv6n	376	4	terminus	terminus	NN
cord-022290-p0l1kv6n	376	5	of	of	IN
cord-022290-p0l1kv6n	376	6	the	the	DT
cord-022290-p0l1kv6n	376	7	L	L	NNP
cord-022290-p0l1kv6n	376	8	proteinase	proteinase	NN
cord-022290-p0l1kv6n	376	9	has	have	VBZ
cord-022290-p0l1kv6n	376	10	an	an	DT
cord-022290-p0l1kv6n	376	11	extension	extension	NN
cord-022290-p0l1kv6n	376	12	,	,	,
cord-022290-p0l1kv6n	376	13	compared	compare	VBN
cord-022290-p0l1kv6n	376	14	to	to	IN
cord-022290-p0l1kv6n	376	15	the	the	DT
cord-022290-p0l1kv6n	376	16	structure	structure	NN
cord-022290-p0l1kv6n	376	17	of	of	IN
cord-022290-p0l1kv6n	376	18	papain	papain	NN
cord-022290-p0l1kv6n	376	19	,	,	,
cord-022290-p0l1kv6n	376	20	which	which	WDT
cord-022290-p0l1kv6n	376	21	has	have	VBZ
cord-022290-p0l1kv6n	376	22	been	be	VBN
cord-022290-p0l1kv6n	376	23	predicted	predict	VBN
cord-022290-p0l1kv6n	376	24	to	to	TO
cord-022290-p0l1kv6n	376	25	adopt	adopt	VB
cord-022290-p0l1kv6n	376	26	a	a	DT
cord-022290-p0l1kv6n	376	27	helical	helical	JJ
cord-022290-p0l1kv6n	376	28	conformation	conformation	NN
cord-022290-p0l1kv6n	376	29	.	.	.
cord-022290-p0l1kv6n	377	1	Skern	Skern	NNP
cord-022290-p0l1kv6n	377	2	et	et	FW
cord-022290-p0l1kv6n	377	3	al	al	NNP
cord-022290-p0l1kv6n	377	4	.	.	.
cord-022290-p0l1kv6n	378	1	(	(	-LRB-
cord-022290-p0l1kv6n	378	2	1998	1998	CD
cord-022290-p0l1kv6n	378	3	)	)	-RRB-
cord-022290-p0l1kv6n	378	4	suggest	suggest	VBP
cord-022290-p0l1kv6n	378	5	that	that	IN
cord-022290-p0l1kv6n	378	6	this	this	DT
cord-022290-p0l1kv6n	378	7	additional	additional	JJ
cord-022290-p0l1kv6n	378	8	helix	helix	NN
cord-022290-p0l1kv6n	378	9	plays	play	VBZ
cord-022290-p0l1kv6n	378	10	an	an	DT
cord-022290-p0l1kv6n	378	11	important	important	JJ
cord-022290-p0l1kv6n	378	12	role	role	NN
cord-022290-p0l1kv6n	378	13	for	for	IN
cord-022290-p0l1kv6n	378	14	the	the	DT
cord-022290-p0l1kv6n	378	15	mechanism	mechanism	NN
cord-022290-p0l1kv6n	378	16	of	of	IN
cord-022290-p0l1kv6n	378	17	the	the	DT
cord-022290-p0l1kv6n	378	18	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	378	19	cleavage	cleavage	NN
cord-022290-p0l1kv6n	378	20	at	at	IN
cord-022290-p0l1kv6n	378	21	the	the	DT
cord-022290-p0l1kv6n	378	22	C	c	NN
cord-022290-p0l1kv6n	378	23	-	-	HYPH
cord-022290-p0l1kv6n	378	24	terminus	terminus	NN
cord-022290-p0l1kv6n	378	25	of	of	IN
cord-022290-p0l1kv6n	378	26	the	the	DT
cord-022290-p0l1kv6n	378	27	L	L	NNP
cord-022290-p0l1kv6n	378	28	proteinase	proteinase	NN
cord-022290-p0l1kv6n	378	29	.	.	.
cord-022290-p0l1kv6n	379	1	Crystallization	crystallization	NN
cord-022290-p0l1kv6n	379	2	of	of	IN
cord-022290-p0l1kv6n	379	3	the	the	DT
cord-022290-p0l1kv6n	379	4	Lb	Lb	NNP
cord-022290-p0l1kv6n	379	5	proteinase	proteinase	NN
cord-022290-p0l1kv6n	379	6	from	from	IN
cord-022290-p0l1kv6n	379	7	FMDV	FMDV	NNP
cord-022290-p0l1kv6n	379	8	has	have	VBZ
cord-022290-p0l1kv6n	379	9	been	be	VBN
cord-022290-p0l1kv6n	379	10	reported	report	VBN
cord-022290-p0l1kv6n	379	11	but	but	CC
cord-022290-p0l1kv6n	379	12	the	the	DT
cord-022290-p0l1kv6n	379	13	crystal	crystal	NN
cord-022290-p0l1kv6n	379	14	structure	structure	NN
cord-022290-p0l1kv6n	379	15	has	have	VBZ
cord-022290-p0l1kv6n	379	16	not	not	RB
cord-022290-p0l1kv6n	379	17	been	be	VBN
cord-022290-p0l1kv6n	379	18	published	publish	VBN
cord-022290-p0l1kv6n	380	1	(	(	-LRB-
cord-022290-p0l1kv6n	380	2	Guarnr	Guarnr	NNP
cord-022290-p0l1kv6n	380	3	et	et	NNP
cord-022290-p0l1kv6n	380	4	al	al	NNP
cord-022290-p0l1kv6n	380	5	.	.	NNP
cord-022290-p0l1kv6n	380	6	,	,	,
cord-022290-p0l1kv6n	380	7	1996	1996	CD
cord-022290-p0l1kv6n	380	8	)	)	-RRB-
cord-022290-p0l1kv6n	380	9	.	.	.
cord-022290-p0l1kv6n	381	1	The	the	DT
cord-022290-p0l1kv6n	381	2	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	381	3	3C	3C	NNP
cord-022290-p0l1kv6n	381	4	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	381	5	constitute	constitute	VBP
cord-022290-p0l1kv6n	381	6	an	an	DT
cord-022290-p0l1kv6n	381	7	ideal	ideal	JJ
cord-022290-p0l1kv6n	381	8	target	target	NN
cord-022290-p0l1kv6n	381	9	for	for	IN
cord-022290-p0l1kv6n	381	10	the	the	DT
cord-022290-p0l1kv6n	381	11	rational	rational	JJ
cord-022290-p0l1kv6n	381	12	design	design	NN
cord-022290-p0l1kv6n	381	13	of	of	IN
cord-022290-p0l1kv6n	381	14	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	381	15	drugs	drug	NNS
cord-022290-p0l1kv6n	381	16	.	.	.
cord-022290-p0l1kv6n	382	1	There	there	EX
cord-022290-p0l1kv6n	382	2	is	be	VBZ
cord-022290-p0l1kv6n	382	3	now	now	RB
cord-022290-p0l1kv6n	382	4	a	a	DT
cord-022290-p0l1kv6n	382	5	considerable	considerable	JJ
cord-022290-p0l1kv6n	382	6	amount	amount	NN
cord-022290-p0l1kv6n	382	7	of	of	IN
cord-022290-p0l1kv6n	382	8	structural	structural	JJ
cord-022290-p0l1kv6n	382	9	information	information	NN
cord-022290-p0l1kv6n	382	10	for	for	IN
cord-022290-p0l1kv6n	382	11	both	both	DT
cord-022290-p0l1kv6n	382	12	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	382	13	and	and	CC
cord-022290-p0l1kv6n	382	14	enzyme	enzyme	NN
cord-022290-p0l1kv6n	382	15	-	-	HYPH
cord-022290-p0l1kv6n	382	16	inhibitor	inhibitor	NN
cord-022290-p0l1kv6n	382	17	complexes	complex	NNS
cord-022290-p0l1kv6n	382	18	.	.	.
cord-022290-p0l1kv6n	383	1	The	the	DT
cord-022290-p0l1kv6n	383	2	details	detail	NNS
cord-022290-p0l1kv6n	383	3	of	of	IN
cord-022290-p0l1kv6n	383	4	the	the	DT
cord-022290-p0l1kv6n	383	5	molecular	molecular	JJ
cord-022290-p0l1kv6n	383	6	interactions	interaction	NNS
cord-022290-p0l1kv6n	383	7	that	that	WDT
cord-022290-p0l1kv6n	383	8	are	be	VBP
cord-022290-p0l1kv6n	383	9	responsible	responsible	JJ
cord-022290-p0l1kv6n	383	10	for	for	IN
cord-022290-p0l1kv6n	383	11	the	the	DT
cord-022290-p0l1kv6n	383	12	specific	specific	JJ
cord-022290-p0l1kv6n	383	13	substrate	substrate	NN
cord-022290-p0l1kv6n	383	14	binding	bind	VBG
cord-022290-p0l1kv6n	383	15	are	be	VBP
cord-022290-p0l1kv6n	383	16	reasonably	reasonably	RB
cord-022290-p0l1kv6n	383	17	well	well	RB
cord-022290-p0l1kv6n	383	18	understood	understand	VBN
cord-022290-p0l1kv6n	383	19	.	.	.
cord-022290-p0l1kv6n	384	1	Furthermore	furthermore	RB
cord-022290-p0l1kv6n	384	2	,	,	,
cord-022290-p0l1kv6n	384	3	the	the	DT
cord-022290-p0l1kv6n	384	4	chymotrypsin	chymotrypsin	JJ
cord-022290-p0l1kv6n	384	5	-	-	HYPH
cord-022290-p0l1kv6n	384	6	like	like	JJ
cord-022290-p0l1kv6n	384	7	cysteine	cysteine	NN
cord-022290-p0l1kv6n	384	8	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	384	9	constitute	constitute	VBP
cord-022290-p0l1kv6n	384	10	a	a	DT
cord-022290-p0l1kv6n	384	11	unique	unique	JJ
cord-022290-p0l1kv6n	384	12	class	class	NN
cord-022290-p0l1kv6n	384	13	of	of	IN
cord-022290-p0l1kv6n	384	14	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	384	15	with	with	IN
cord-022290-p0l1kv6n	384	16	a	a	DT
cord-022290-p0l1kv6n	384	17	distinct	distinct	JJ
cord-022290-p0l1kv6n	384	18	substrate	substrate	NN
cord-022290-p0l1kv6n	384	19	specificity	specificity	NN
cord-022290-p0l1kv6n	384	20	and	and	CC
cord-022290-p0l1kv6n	384	21	are	be	VBP
cord-022290-p0l1kv6n	384	22	so	so	RB
cord-022290-p0l1kv6n	384	23	far	far	RB
cord-022290-p0l1kv6n	384	24	only	only	RB
cord-022290-p0l1kv6n	384	25	found	find	VBN
cord-022290-p0l1kv6n	384	26	in	in	IN
cord-022290-p0l1kv6n	384	27	+	+	CC
cord-022290-p0l1kv6n	384	28	RNA	RNA	NNP
cord-022290-p0l1kv6n	384	29	viruses	virus	NNS
cord-022290-p0l1kv6n	384	30	.	.	.
cord-022290-p0l1kv6n	385	1	Within	within	IN
cord-022290-p0l1kv6n	385	2	these	these	DT
cord-022290-p0l1kv6n	385	3	viruses	virus	NNS
cord-022290-p0l1kv6n	385	4	the	the	DT
cord-022290-p0l1kv6n	385	5	3C	3C	NNP
cord-022290-p0l1kv6n	385	6	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	385	7	perform	perform	VBP
cord-022290-p0l1kv6n	385	8	a	a	DT
cord-022290-p0l1kv6n	385	9	central	central	JJ
cord-022290-p0l1kv6n	385	10	and	and	CC
cord-022290-p0l1kv6n	385	11	indispensable	indispensable	JJ
cord-022290-p0l1kv6n	385	12	role	role	NN
cord-022290-p0l1kv6n	385	13	during	during	IN
cord-022290-p0l1kv6n	385	14	the	the	DT
cord-022290-p0l1kv6n	385	15	viral	viral	JJ
cord-022290-p0l1kv6n	385	16	life	life	NN
cord-022290-p0l1kv6n	385	17	cycle	cycle	NN
cord-022290-p0l1kv6n	385	18	and	and	CC
cord-022290-p0l1kv6n	385	19	3C	3c	NN
cord-022290-p0l1kv6n	385	20	proteinase	proteinase	NN
cord-022290-p0l1kv6n	385	21	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	386	1	have	have	VB
cord-022290-p0l1kv6n	386	2	the	the	DT
cord-022290-p0l1kv6n	386	3	potential	potential	NN
cord-022290-p0l1kv6n	386	4	to	to	TO
cord-022290-p0l1kv6n	386	5	limit	limit	VB
cord-022290-p0l1kv6n	386	6	the	the	DT
cord-022290-p0l1kv6n	386	7	spread	spread	NN
cord-022290-p0l1kv6n	386	8	of	of	IN
cord-022290-p0l1kv6n	386	9	viral	viral	JJ
cord-022290-p0l1kv6n	386	10	infections	infection	NNS
cord-022290-p0l1kv6n	386	11	(	(	-LRB-
cord-022290-p0l1kv6n	386	12	Morris	Morris	NNP
cord-022290-p0l1kv6n	386	13	et	et	NNP
cord-022290-p0l1kv6n	386	14	al	al	NNP
cord-022290-p0l1kv6n	386	15	.	.	NNP
cord-022290-p0l1kv6n	386	16	,	,	,
cord-022290-p0l1kv6n	386	17	1997	1997	CD
cord-022290-p0l1kv6n	386	18	)	)	-RRB-
cord-022290-p0l1kv6n	386	19	.	.	.
cord-022290-p0l1kv6n	387	1	Neither	neither	CC
cord-022290-p0l1kv6n	387	2	the	the	DT
cord-022290-p0l1kv6n	387	3	2A	2a	CD
cord-022290-p0l1kv6n	387	4	nor	nor	CC
cord-022290-p0l1kv6n	387	5	the	the	DT
cord-022290-p0l1kv6n	387	6	L	L	NNP
cord-022290-p0l1kv6n	387	7	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	387	8	are	be	VBP
cord-022290-p0l1kv6n	387	9	as	as	RB
cord-022290-p0l1kv6n	387	10	attractive	attractive	JJ
cord-022290-p0l1kv6n	387	11	as	as	IN
cord-022290-p0l1kv6n	387	12	targets	target	NNS
cord-022290-p0l1kv6n	387	13	for	for	IN
cord-022290-p0l1kv6n	387	14	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	387	15	strategies	strategy	NNS
cord-022290-p0l1kv6n	387	16	.	.	.
cord-022290-p0l1kv6n	388	1	The	the	DT
cord-022290-p0l1kv6n	388	2	activity	activity	NN
cord-022290-p0l1kv6n	388	3	of	of	IN
cord-022290-p0l1kv6n	388	4	the	the	DT
cord-022290-p0l1kv6n	388	5	L	l	NN
cord-022290-p0l1kv6n	388	6	proteinase	proteinase	NN
cord-022290-p0l1kv6n	388	7	is	be	VBZ
cord-022290-p0l1kv6n	388	8	apparently	apparently	RB
cord-022290-p0l1kv6n	388	9	not	not	RB
cord-022290-p0l1kv6n	388	10	as	as	RB
cord-022290-p0l1kv6n	388	11	critical	critical	JJ
cord-022290-p0l1kv6n	388	12	for	for	IN
cord-022290-p0l1kv6n	388	13	viral	viral	JJ
cord-022290-p0l1kv6n	388	14	replication	replication	NN
cord-022290-p0l1kv6n	388	15	.	.	.
cord-022290-p0l1kv6n	389	1	There	there	EX
cord-022290-p0l1kv6n	389	2	is	be	VBZ
cord-022290-p0l1kv6n	389	3	not	not	RB
cord-022290-p0l1kv6n	389	4	as	as	RB
cord-022290-p0l1kv6n	389	5	much	much	JJ
cord-022290-p0l1kv6n	389	6	structural	structural	JJ
cord-022290-p0l1kv6n	389	7	information	information	NN
cord-022290-p0l1kv6n	389	8	available	available	JJ
cord-022290-p0l1kv6n	389	9	for	for	IN
cord-022290-p0l1kv6n	389	10	the	the	DT
cord-022290-p0l1kv6n	389	11	entero-/rhinoviral	entero-/rhinoviral	JJ
cord-022290-p0l1kv6n	389	12	2A	2a	CD
cord-022290-p0l1kv6n	389	13	proteinase	proteinase	NN
cord-022290-p0l1kv6n	389	14	.	.	.
cord-022290-p0l1kv6n	390	1	The	the	DT
cord-022290-p0l1kv6n	390	2	fact	fact	NN
cord-022290-p0l1kv6n	390	3	that	that	IN
cord-022290-p0l1kv6n	390	4	the	the	DT
cord-022290-p0l1kv6n	390	5	2A	2a	CD
cord-022290-p0l1kv6n	390	6	proteinase	proteinase	NN
cord-022290-p0l1kv6n	390	7	activity	activity	NN
cord-022290-p0l1kv6n	390	8	is	be	VBZ
cord-022290-p0l1kv6n	390	9	also	also	RB
cord-022290-p0l1kv6n	390	10	less	less	RBR
cord-022290-p0l1kv6n	390	11	stringently	stringently	RB
cord-022290-p0l1kv6n	390	12	specific	specific	JJ
cord-022290-p0l1kv6n	390	13	could	could	MD
cord-022290-p0l1kv6n	390	14	make	make	VB
cord-022290-p0l1kv6n	390	15	the	the	DT
cord-022290-p0l1kv6n	390	16	design	design	NN
cord-022290-p0l1kv6n	390	17	of	of	IN
cord-022290-p0l1kv6n	390	18	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	390	19	more	more	RBR
cord-022290-p0l1kv6n	390	20	difficult	difficult	JJ
cord-022290-p0l1kv6n	390	21	.	.	.
cord-022290-p0l1kv6n	391	1	While	while	IN
cord-022290-p0l1kv6n	391	2	there	there	EX
cord-022290-p0l1kv6n	391	3	are	be	VBP
cord-022290-p0l1kv6n	391	4	many	many	JJ
cord-022290-p0l1kv6n	391	5	Picornaviruses	Picornaviruses	NNPS
cord-022290-p0l1kv6n	391	6	,	,	,
cord-022290-p0l1kv6n	391	7	and	and	CC
cord-022290-p0l1kv6n	391	8	viruses	virus	NNS
cord-022290-p0l1kv6n	391	9	from	from	IN
cord-022290-p0l1kv6n	391	10	related	related	JJ
cord-022290-p0l1kv6n	391	11	families	family	NNS
cord-022290-p0l1kv6n	391	12	,	,	,
cord-022290-p0l1kv6n	391	13	that	that	WDT
cord-022290-p0l1kv6n	391	14	cause	cause	VBP
cord-022290-p0l1kv6n	391	15	disease	disease	NN
cord-022290-p0l1kv6n	391	16	in	in	IN
cord-022290-p0l1kv6n	391	17	humans	human	NNS
cord-022290-p0l1kv6n	391	18	,	,	,
cord-022290-p0l1kv6n	391	19	few	few	JJ
cord-022290-p0l1kv6n	391	20	of	of	IN
cord-022290-p0l1kv6n	391	21	these	these	DT
cord-022290-p0l1kv6n	391	22	are	be	VBP
cord-022290-p0l1kv6n	391	23	considered	consider	VBN
cord-022290-p0l1kv6n	391	24	important	important	JJ
cord-022290-p0l1kv6n	391	25	targets	target	NNS
cord-022290-p0l1kv6n	391	26	for	for	IN
cord-022290-p0l1kv6n	391	27	the	the	DT
cord-022290-p0l1kv6n	391	28	design	design	NN
cord-022290-p0l1kv6n	391	29	of	of	IN
cord-022290-p0l1kv6n	391	30	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	391	31	drugs	drug	NNS
cord-022290-p0l1kv6n	391	32	.	.	.
cord-022290-p0l1kv6n	392	1	Rhinoviruses	rhinovirus	NNS
cord-022290-p0l1kv6n	392	2	cause	cause	VBP
cord-022290-p0l1kv6n	392	3	at	at	IN
cord-022290-p0l1kv6n	392	4	least	least	JJS
cord-022290-p0l1kv6n	392	5	half	half	NN
cord-022290-p0l1kv6n	392	6	of	of	IN
cord-022290-p0l1kv6n	392	7	all	all	DT
cord-022290-p0l1kv6n	392	8	common	common	JJ
cord-022290-p0l1kv6n	392	9	colds	cold	NNS
cord-022290-p0l1kv6n	392	10	in	in	IN
cord-022290-p0l1kv6n	392	11	humans	human	NNS
cord-022290-p0l1kv6n	392	12	.	.	.
cord-022290-p0l1kv6n	393	1	But	but	CC
cord-022290-p0l1kv6n	393	2	because	because	IN
cord-022290-p0l1kv6n	393	3	there	there	EX
cord-022290-p0l1kv6n	393	4	are	be	VBP
cord-022290-p0l1kv6n	393	5	other	other	JJ
cord-022290-p0l1kv6n	393	6	families	family	NNS
cord-022290-p0l1kv6n	393	7	of	of	IN
cord-022290-p0l1kv6n	393	8	unrelated	unrelated	JJ
cord-022290-p0l1kv6n	393	9	viruses	virus	NNS
cord-022290-p0l1kv6n	393	10	that	that	WDT
cord-022290-p0l1kv6n	393	11	cause	cause	VBP
cord-022290-p0l1kv6n	393	12	upper	upper	JJ
cord-022290-p0l1kv6n	393	13	respiratory	respiratory	JJ
cord-022290-p0l1kv6n	393	14	tract	tract	NN
cord-022290-p0l1kv6n	393	15	infections	infection	NNS
cord-022290-p0l1kv6n	393	16	,	,	,
cord-022290-p0l1kv6n	393	17	which	which	WDT
cord-022290-p0l1kv6n	393	18	are	be	VBP
cord-022290-p0l1kv6n	393	19	essentially	essentially	RB
cord-022290-p0l1kv6n	393	20	indistinguishable	indistinguishable	JJ
cord-022290-p0l1kv6n	393	21	,	,	,
cord-022290-p0l1kv6n	393	22	effective	effective	JJ
cord-022290-p0l1kv6n	393	23	drugs	drug	NNS
cord-022290-p0l1kv6n	393	24	against	against	IN
cord-022290-p0l1kv6n	393	25	rhinoviruses	rhinovirus	NNS
cord-022290-p0l1kv6n	393	26	would	would	MD
cord-022290-p0l1kv6n	393	27	only	only	RB
cord-022290-p0l1kv6n	393	28	be	be	VB
cord-022290-p0l1kv6n	393	29	useful	useful	JJ
cord-022290-p0l1kv6n	393	30	in	in	IN
cord-022290-p0l1kv6n	393	31	combination	combination	NN
cord-022290-p0l1kv6n	393	32	with	with	IN
cord-022290-p0l1kv6n	393	33	simple	simple	JJ
cord-022290-p0l1kv6n	393	34	analytical	analytical	JJ
cord-022290-p0l1kv6n	393	35	procedures	procedure	NNS
cord-022290-p0l1kv6n	393	36	to	to	TO
cord-022290-p0l1kv6n	393	37	unambiguously	unambiguously	RB
cord-022290-p0l1kv6n	393	38	identify	identify	VB
cord-022290-p0l1kv6n	393	39	rhinoviral	rhinoviral	JJ
cord-022290-p0l1kv6n	393	40	infections	infection	NNS
cord-022290-p0l1kv6n	393	41	.	.	.
cord-022290-p0l1kv6n	394	1	Such	such	JJ
cord-022290-p0l1kv6n	394	2	simple	simple	JJ
cord-022290-p0l1kv6n	394	3	analytical	analytical	JJ
cord-022290-p0l1kv6n	394	4	procedures	procedure	NNS
cord-022290-p0l1kv6n	394	5	are	be	VBP
cord-022290-p0l1kv6n	394	6	not	not	RB
cord-022290-p0l1kv6n	394	7	available	available	JJ
cord-022290-p0l1kv6n	394	8	at	at	IN
cord-022290-p0l1kv6n	394	9	present	present	JJ
cord-022290-p0l1kv6n	394	10	(	(	-LRB-
cord-022290-p0l1kv6n	394	11	Couch	couch	NN
cord-022290-p0l1kv6n	394	12	,	,	,
cord-022290-p0l1kv6n	394	13	1996	1996	CD
cord-022290-p0l1kv6n	394	14	)	)	-RRB-
cord-022290-p0l1kv6n	394	15	.	.	.
cord-022290-p0l1kv6n	395	1	There	there	EX
cord-022290-p0l1kv6n	395	2	are	be	VBP
cord-022290-p0l1kv6n	395	3	safe	safe	JJ
cord-022290-p0l1kv6n	395	4	and	and	CC
cord-022290-p0l1kv6n	395	5	effective	effective	JJ
cord-022290-p0l1kv6n	395	6	vaccines	vaccine	NNS
cord-022290-p0l1kv6n	395	7	available	available	JJ
cord-022290-p0l1kv6n	395	8	against	against	IN
cord-022290-p0l1kv6n	395	9	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	395	10	and	and	CC
cord-022290-p0l1kv6n	395	11	HAV	HAV	NNP
cord-022290-p0l1kv6n	395	12	.	.	.
cord-022290-p0l1kv6n	396	1	As	as	IN
cord-022290-p0l1kv6n	396	2	a	a	DT
cord-022290-p0l1kv6n	396	3	result	result	NN
cord-022290-p0l1kv6n	396	4	of	of	IN
cord-022290-p0l1kv6n	396	5	extensive	extensive	JJ
cord-022290-p0l1kv6n	396	6	worldwide	worldwide	JJ
cord-022290-p0l1kv6n	396	7	vaccination	vaccination	NN
cord-022290-p0l1kv6n	396	8	,	,	,
cord-022290-p0l1kv6n	396	9	the	the	DT
cord-022290-p0l1kv6n	396	10	incidence	incidence	NN
cord-022290-p0l1kv6n	396	11	of	of	IN
cord-022290-p0l1kv6n	396	12	poliomyelitis	poliomyelitis	NN
cord-022290-p0l1kv6n	396	13	has	have	VBZ
cord-022290-p0l1kv6n	396	14	been	be	VBN
cord-022290-p0l1kv6n	396	15	decreasing	decrease	VBG
cord-022290-p0l1kv6n	396	16	and	and	CC
cord-022290-p0l1kv6n	396	17	currently	currently	RB
cord-022290-p0l1kv6n	396	18	there	there	EX
cord-022290-p0l1kv6n	396	19	are	be	VBP
cord-022290-p0l1kv6n	396	20	realistic	realistic	JJ
cord-022290-p0l1kv6n	396	21	efforts	effort	NNS
cord-022290-p0l1kv6n	396	22	underway	underway	JJ
cord-022290-p0l1kv6n	396	23	to	to	TO
cord-022290-p0l1kv6n	396	24	eradicate	eradicate	VB
cord-022290-p0l1kv6n	396	25	the	the	DT
cord-022290-p0l1kv6n	396	26	disease	disease	NN
cord-022290-p0l1kv6n	396	27	completely	completely	RB
cord-022290-p0l1kv6n	396	28	.	.	.
cord-022290-p0l1kv6n	397	1	The	the	DT
cord-022290-p0l1kv6n	397	2	introduction	introduction	NN
cord-022290-p0l1kv6n	397	3	of	of	IN
cord-022290-p0l1kv6n	397	4	an	an	DT
cord-022290-p0l1kv6n	397	5	effective	effective	JJ
cord-022290-p0l1kv6n	397	6	vaccine	vaccine	NN
cord-022290-p0l1kv6n	397	7	against	against	IN
cord-022290-p0l1kv6n	397	8	HAV	HAV	NNP
cord-022290-p0l1kv6n	397	9	was	be	VBD
cord-022290-p0l1kv6n	397	10	very	very	RB
cord-022290-p0l1kv6n	397	11	recent	recent	JJ
cord-022290-p0l1kv6n	397	12	and	and	CC
cord-022290-p0l1kv6n	397	13	it	-PRON-	PRP
cord-022290-p0l1kv6n	397	14	is	be	VBZ
cord-022290-p0l1kv6n	397	15	too	too	RB
cord-022290-p0l1kv6n	397	16	early	early	JJ
cord-022290-p0l1kv6n	397	17	to	to	TO
cord-022290-p0l1kv6n	397	18	predict	predict	VB
cord-022290-p0l1kv6n	397	19	its	-PRON-	PRP$
cord-022290-p0l1kv6n	397	20	effect	effect	NN
cord-022290-p0l1kv6n	397	21	.	.	.
cord-022290-p0l1kv6n	398	1	Wide	wide	JJ
cord-022290-p0l1kv6n	398	2	-	-	HYPH
cord-022290-p0l1kv6n	398	3	spread	spread	NN
cord-022290-p0l1kv6n	398	4	vaccination	vaccination	NN
cord-022290-p0l1kv6n	398	5	against	against	IN
cord-022290-p0l1kv6n	398	6	HAV	HAV	NNP
cord-022290-p0l1kv6n	398	7	is	be	VBZ
cord-022290-p0l1kv6n	398	8	currently	currently	RB
cord-022290-p0l1kv6n	398	9	not	not	RB
cord-022290-p0l1kv6n	398	10	planned	plan	VBN
cord-022290-p0l1kv6n	398	11	as	as	IN
cord-022290-p0l1kv6n	398	12	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	398	13	A	A	NNP
cord-022290-p0l1kv6n	398	14	is	be	VBZ
cord-022290-p0l1kv6n	398	15	usually	usually	RB
cord-022290-p0l1kv6n	398	16	not	not	RB
cord-022290-p0l1kv6n	398	17	a	a	DT
cord-022290-p0l1kv6n	398	18	lifethreatening	lifethreatening	JJ
cord-022290-p0l1kv6n	398	19	disease	disease	NN
cord-022290-p0l1kv6n	398	20	.	.	.
cord-022290-p0l1kv6n	399	1	Because	because	IN
cord-022290-p0l1kv6n	399	2	co	co	NNS
cord-022290-p0l1kv6n	399	3	-	-	NNS
cord-022290-p0l1kv6n	399	4	infections	infection	NNS
cord-022290-p0l1kv6n	399	5	of	of	IN
cord-022290-p0l1kv6n	399	6	chronic	chronic	JJ
cord-022290-p0l1kv6n	399	7	carriers	carrier	NNS
cord-022290-p0l1kv6n	399	8	of	of	IN
cord-022290-p0l1kv6n	399	9	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	399	10	B	B	NNP
cord-022290-p0l1kv6n	399	11	,	,	,
cord-022290-p0l1kv6n	399	12	C	C	NNP
cord-022290-p0l1kv6n	399	13	,	,	,
cord-022290-p0l1kv6n	399	14	and	and	CC
cord-022290-p0l1kv6n	399	15	G	g	NN
cord-022290-p0l1kv6n	399	16	with	with	IN
cord-022290-p0l1kv6n	399	17	HAV	HAV	NNP
cord-022290-p0l1kv6n	399	18	appears	appear	VBZ
cord-022290-p0l1kv6n	399	19	to	to	TO
cord-022290-p0l1kv6n	399	20	be	be	VB
cord-022290-p0l1kv6n	399	21	dangerous	dangerous	JJ
cord-022290-p0l1kv6n	399	22	,	,	,
cord-022290-p0l1kv6n	399	23	the	the	DT
cord-022290-p0l1kv6n	399	24	observed	observed	JJ
cord-022290-p0l1kv6n	399	25	increase	increase	NN
cord-022290-p0l1kv6n	399	26	in	in	IN
cord-022290-p0l1kv6n	399	27	chronic	chronic	JJ
cord-022290-p0l1kv6n	399	28	infections	infection	NNS
cord-022290-p0l1kv6n	399	29	with	with	IN
cord-022290-p0l1kv6n	399	30	other	other	JJ
cord-022290-p0l1kv6n	399	31	forms	form	NNS
cord-022290-p0l1kv6n	399	32	of	of	IN
cord-022290-p0l1kv6n	399	33	hepatitis	hepatitis	NN
cord-022290-p0l1kv6n	399	34	may	may	MD
cord-022290-p0l1kv6n	399	35	have	have	VB
cord-022290-p0l1kv6n	399	36	an	an	DT
cord-022290-p0l1kv6n	399	37	influence	influence	NN
cord-022290-p0l1kv6n	399	38	on	on	IN
cord-022290-p0l1kv6n	399	39	future	future	JJ
cord-022290-p0l1kv6n	399	40	strategies	strategy	NNS
cord-022290-p0l1kv6n	399	41	to	to	TO
cord-022290-p0l1kv6n	399	42	control	control	VB
cord-022290-p0l1kv6n	399	43	hepatitis	hepatitis	NN
cord-022290-p0l1kv6n	399	44	A.	a.	NN
cord-022290-p0l1kv6n	400	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	400	2	would	would	MD
cord-022290-p0l1kv6n	400	3	be	be	VB
cord-022290-p0l1kv6n	400	4	desirable	desirable	JJ
cord-022290-p0l1kv6n	400	5	to	to	TO
cord-022290-p0l1kv6n	400	6	have	have	VB
cord-022290-p0l1kv6n	400	7	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	400	8	drugs	drug	NNS
cord-022290-p0l1kv6n	400	9	available	available	JJ
cord-022290-p0l1kv6n	400	10	against	against	IN
cord-022290-p0l1kv6n	400	11	the	the	DT
cord-022290-p0l1kv6n	400	12	more	more	RBR
cord-022290-p0l1kv6n	400	13	severe	severe	JJ
cord-022290-p0l1kv6n	400	14	enteroviral	enteroviral	JJ
cord-022290-p0l1kv6n	400	15	infections	infection	NNS
cord-022290-p0l1kv6n	400	16	.	.	.
cord-022290-p0l1kv6n	401	1	While	while	IN
cord-022290-p0l1kv6n	401	2	most	most	JJS
cord-022290-p0l1kv6n	401	3	of	of	IN
cord-022290-p0l1kv6n	401	4	the	the	DT
cord-022290-p0l1kv6n	401	5	enteroviral	enteroviral	JJ
cord-022290-p0l1kv6n	401	6	infections	infection	NNS
cord-022290-p0l1kv6n	401	7	are	be	VBP
cord-022290-p0l1kv6n	401	8	rare	rare	JJ
cord-022290-p0l1kv6n	401	9	,	,	,
cord-022290-p0l1kv6n	401	10	they	-PRON-	PRP
cord-022290-p0l1kv6n	401	11	can	can	MD
cord-022290-p0l1kv6n	401	12	have	have	VB
cord-022290-p0l1kv6n	401	13	serious	serious	JJ
cord-022290-p0l1kv6n	401	14	consequences	consequence	NNS
cord-022290-p0l1kv6n	401	15	.	.	.
cord-022290-p0l1kv6n	402	1	Because	because	IN
cord-022290-p0l1kv6n	402	2	enteroviral	enteroviral	JJ
cord-022290-p0l1kv6n	402	3	infections	infection	NNS
cord-022290-p0l1kv6n	402	4	occur	occur	VBP
cord-022290-p0l1kv6n	402	5	infrequently	infrequently	RB
cord-022290-p0l1kv6n	402	6	,	,	,
cord-022290-p0l1kv6n	402	7	this	this	DT
cord-022290-p0l1kv6n	402	8	is	be	VBZ
cord-022290-p0l1kv6n	402	9	not	not	RB
cord-022290-p0l1kv6n	402	10	considered	consider	VBN
cord-022290-p0l1kv6n	402	11	an	an	DT
cord-022290-p0l1kv6n	402	12	economically	economically	RB
cord-022290-p0l1kv6n	402	13	important	important	JJ
cord-022290-p0l1kv6n	402	14	target	target	NN
cord-022290-p0l1kv6n	402	15	.	.	.
cord-022290-p0l1kv6n	403	1	Several	several	JJ
cord-022290-p0l1kv6n	403	2	other	other	JJ
cord-022290-p0l1kv6n	403	3	families	family	NNS
cord-022290-p0l1kv6n	403	4	of	of	IN
cord-022290-p0l1kv6n	403	5	+	+	SYM
cord-022290-p0l1kv6n	403	6	RNA	RNA	NNP
cord-022290-p0l1kv6n	403	7	viruses	virus	NNS
cord-022290-p0l1kv6n	403	8	also	also	RB
cord-022290-p0l1kv6n	403	9	carry	carry	VBP
cord-022290-p0l1kv6n	403	10	3C	3c	NN
cord-022290-p0l1kv6n	403	11	or	or	CC
cord-022290-p0l1kv6n	403	12	3C	3c	NN
cord-022290-p0l1kv6n	403	13	-	-	HYPH
cord-022290-p0l1kv6n	403	14	like	like	JJ
cord-022290-p0l1kv6n	403	15	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	403	16	(	(	-LRB-
cord-022290-p0l1kv6n	403	17	Wirblich	Wirblich	NNP
cord-022290-p0l1kv6n	403	18	et	et	NNP
cord-022290-p0l1kv6n	403	19	al	al	NNP
cord-022290-p0l1kv6n	403	20	.	.	NNP
cord-022290-p0l1kv6n	403	21	,	,	,
cord-022290-p0l1kv6n	403	22	1995	1995	CD
cord-022290-p0l1kv6n	403	23	;	;	:
cord-022290-p0l1kv6n	403	24	Martin	Martin	NNP
cord-022290-p0l1kv6n	403	25	Alonso	Alonso	NNP
cord-022290-p0l1kv6n	403	26	et	et	NNP
cord-022290-p0l1kv6n	403	27	al	al	NNP
cord-022290-p0l1kv6n	403	28	.	.	NNP
cord-022290-p0l1kv6n	403	29	,	,	,
cord-022290-p0l1kv6n	403	30	1995	1995	CD
cord-022290-p0l1kv6n	403	31	;	;	:
cord-022290-p0l1kv6n	403	32	Tibbles	Tibbles	NNP
cord-022290-p0l1kv6n	403	33	et	et	NNP
cord-022290-p0l1kv6n	403	34	al	al	NNP
cord-022290-p0l1kv6n	403	35	.	.	NNP
cord-022290-p0l1kv6n	403	36	,	,	,
cord-022290-p0l1kv6n	403	37	1996	1996	CD
cord-022290-p0l1kv6n	403	38	)	)	-RRB-
cord-022290-p0l1kv6n	403	39	.	.	.
cord-022290-p0l1kv6n	404	1	Most	most	RBS
cord-022290-p0l1kv6n	404	2	notably	notably	RB
cord-022290-p0l1kv6n	404	3	,	,	,
cord-022290-p0l1kv6n	404	4	the	the	DT
cord-022290-p0l1kv6n	404	5	Corona	Corona	NNP
cord-022290-p0l1kv6n	404	6	-	-	HYPH
cord-022290-p0l1kv6n	404	7	and	and	CC
cord-022290-p0l1kv6n	404	8	Caliciviridae	Caliciviridae	NNP
cord-022290-p0l1kv6n	404	9	cause	cause	VBP
cord-022290-p0l1kv6n	404	10	upper	upper	JJ
cord-022290-p0l1kv6n	404	11	respiratory	respiratory	JJ
cord-022290-p0l1kv6n	404	12	tract	tract	NN
cord-022290-p0l1kv6n	404	13	infections	infection	NNS
cord-022290-p0l1kv6n	404	14	and	and	CC
cord-022290-p0l1kv6n	404	15	intestinal	intestinal	JJ
cord-022290-p0l1kv6n	404	16	infections	infection	NNS
cord-022290-p0l1kv6n	404	17	in	in	IN
cord-022290-p0l1kv6n	404	18	humans	human	NNS
cord-022290-p0l1kv6n	404	19	.	.	.
cord-022290-p0l1kv6n	405	1	The	the	DT
cord-022290-p0l1kv6n	405	2	viruses	virus	NNS
cord-022290-p0l1kv6n	405	3	of	of	IN
cord-022290-p0l1kv6n	405	4	these	these	DT
cord-022290-p0l1kv6n	405	5	families	family	NNS
cord-022290-p0l1kv6n	405	6	are	be	VBP
cord-022290-p0l1kv6n	405	7	less	less	RBR
cord-022290-p0l1kv6n	405	8	well	well	RB
cord-022290-p0l1kv6n	405	9	studied	study	VBN
cord-022290-p0l1kv6n	405	10	than	than	IN
cord-022290-p0l1kv6n	405	11	the	the	DT
cord-022290-p0l1kv6n	405	12	Picornaviruses	Picornaviruses	NNP
cord-022290-p0l1kv6n	405	13	but	but	CC
cord-022290-p0l1kv6n	405	14	distantly	distantly	RB
cord-022290-p0l1kv6n	405	15	related	related	JJ
cord-022290-p0l1kv6n	405	16	.	.	.
cord-022290-p0l1kv6n	406	1	The	the	DT
cord-022290-p0l1kv6n	406	2	design	design	NN
cord-022290-p0l1kv6n	406	3	of	of	IN
cord-022290-p0l1kv6n	406	4	3C	3C	NNP
cord-022290-p0l1kv6n	406	5	proteinase	proteinase	NN
cord-022290-p0l1kv6n	406	6	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	406	7	would	would	MD
cord-022290-p0l1kv6n	406	8	in	in	IN
cord-022290-p0l1kv6n	406	9	all	all	DT
cord-022290-p0l1kv6n	406	10	likelihood	likelihood	NN
cord-022290-p0l1kv6n	406	11	also	also	RB
cord-022290-p0l1kv6n	406	12	be	be	VB
cord-022290-p0l1kv6n	406	13	useful	useful	JJ
cord-022290-p0l1kv6n	406	14	toward	toward	IN
cord-022290-p0l1kv6n	406	15	the	the	DT
cord-022290-p0l1kv6n	406	16	development	development	NN
cord-022290-p0l1kv6n	406	17	of	of	IN
cord-022290-p0l1kv6n	406	18	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	406	19	drugs	drug	NNS
cord-022290-p0l1kv6n	406	20	against	against	IN
cord-022290-p0l1kv6n	406	21	the	the	DT
cord-022290-p0l1kv6n	406	22	3C	3C	NNP
cord-022290-p0l1kv6n	406	23	-	-	HYPH
cord-022290-p0l1kv6n	406	24	like	like	JJ
cord-022290-p0l1kv6n	406	25	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	406	26	of	of	IN
cord-022290-p0l1kv6n	406	27	the	the	DT
cord-022290-p0l1kv6n	406	28	viruses	virus	NNS
cord-022290-p0l1kv6n	406	29	of	of	IN
cord-022290-p0l1kv6n	406	30	these	these	DT
cord-022290-p0l1kv6n	406	31	families	family	NNS
cord-022290-p0l1kv6n	406	32	.	.	.
cord-022290-p0l1kv6n	407	1	At	at	IN
cord-022290-p0l1kv6n	407	2	present	present	JJ
cord-022290-p0l1kv6n	407	3	the	the	DT
cord-022290-p0l1kv6n	407	4	mechanism	mechanism	NN
cord-022290-p0l1kv6n	407	5	by	by	IN
cord-022290-p0l1kv6n	407	6	which	which	WDT
cord-022290-p0l1kv6n	407	7	some	some	DT
cord-022290-p0l1kv6n	407	8	+	+	SYM
cord-022290-p0l1kv6n	407	9	RNA	RNA	NNP
cord-022290-p0l1kv6n	407	10	viruses	virus	NNS
cord-022290-p0l1kv6n	407	11	,	,	,
cord-022290-p0l1kv6n	407	12	most	most	RBS
cord-022290-p0l1kv6n	407	13	notably	notably	RB
cord-022290-p0l1kv6n	407	14	the	the	DT
cord-022290-p0l1kv6n	407	15	enteroviruses	enterovirus	NNS
cord-022290-p0l1kv6n	407	16	,	,	,
cord-022290-p0l1kv6n	407	17	can	can	MD
cord-022290-p0l1kv6n	407	18	trigger	trigger	VB
cord-022290-p0l1kv6n	407	19	severe	severe	JJ
cord-022290-p0l1kv6n	407	20	autoimmune	autoimmune	JJ
cord-022290-p0l1kv6n	407	21	diseases	disease	NNS
cord-022290-p0l1kv6n	407	22	are	be	VBP
cord-022290-p0l1kv6n	407	23	not	not	RB
cord-022290-p0l1kv6n	407	24	well	well	RB
cord-022290-p0l1kv6n	407	25	understood	understand	VBN
cord-022290-p0l1kv6n	407	26	.	.	.
cord-022290-p0l1kv6n	408	1	It	-PRON-	PRP
cord-022290-p0l1kv6n	408	2	is	be	VBZ
cord-022290-p0l1kv6n	408	3	also	also	RB
cord-022290-p0l1kv6n	408	4	questionable	questionable	JJ
cord-022290-p0l1kv6n	408	5	whether	whether	IN
cord-022290-p0l1kv6n	408	6	inhibition	inhibition	NN
cord-022290-p0l1kv6n	408	7	of	of	IN
cord-022290-p0l1kv6n	408	8	viral	viral	JJ
cord-022290-p0l1kv6n	408	9	replication	replication	NN
cord-022290-p0l1kv6n	408	10	would	would	MD
cord-022290-p0l1kv6n	408	11	prevent	prevent	VB
cord-022290-p0l1kv6n	408	12	the	the	DT
cord-022290-p0l1kv6n	408	13	disastrous	disastrous	JJ
cord-022290-p0l1kv6n	408	14	consequences	consequence	NNS
cord-022290-p0l1kv6n	408	15	of	of	IN
cord-022290-p0l1kv6n	408	16	the	the	DT
cord-022290-p0l1kv6n	408	17	immune	immune	JJ
cord-022290-p0l1kv6n	408	18	response	response	NN
cord-022290-p0l1kv6n	408	19	at	at	IN
cord-022290-p0l1kv6n	408	20	a	a	DT
cord-022290-p0l1kv6n	408	21	later	later	JJ
cord-022290-p0l1kv6n	408	22	stage	stage	NN
cord-022290-p0l1kv6n	408	23	of	of	IN
cord-022290-p0l1kv6n	408	24	an	an	DT
cord-022290-p0l1kv6n	408	25	infection	infection	NN
cord-022290-p0l1kv6n	408	26	.	.	.
cord-022290-p0l1kv6n	409	1	Therefore	therefore	RB
cord-022290-p0l1kv6n	409	2	,	,	,
cord-022290-p0l1kv6n	409	3	it	-PRON-	PRP
cord-022290-p0l1kv6n	409	4	is	be	VBZ
cord-022290-p0l1kv6n	409	5	not	not	RB
cord-022290-p0l1kv6n	409	6	clear	clear	JJ
cord-022290-p0l1kv6n	409	7	whether	whether	IN
cord-022290-p0l1kv6n	409	8	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	409	9	drugs	drug	NNS
cord-022290-p0l1kv6n	409	10	would	would	MD
cord-022290-p0l1kv6n	409	11	be	be	VB
cord-022290-p0l1kv6n	409	12	useful	useful	JJ
cord-022290-p0l1kv6n	409	13	in	in	IN
cord-022290-p0l1kv6n	409	14	the	the	DT
cord-022290-p0l1kv6n	409	15	prevention	prevention	NN
cord-022290-p0l1kv6n	409	16	of	of	IN
cord-022290-p0l1kv6n	409	17	these	these	DT
cord-022290-p0l1kv6n	409	18	diseases	disease	NNS
cord-022290-p0l1kv6n	409	19	.	.	.
cord-022290-p0l1kv6n	410	1	In	in	IN
cord-022290-p0l1kv6n	410	2	conclusion	conclusion	NN
cord-022290-p0l1kv6n	410	3	,	,	,
cord-022290-p0l1kv6n	410	4	there	there	EX
cord-022290-p0l1kv6n	410	5	is	be	VBZ
cord-022290-p0l1kv6n	410	6	a	a	DT
cord-022290-p0l1kv6n	410	7	wealth	wealth	NN
cord-022290-p0l1kv6n	410	8	of	of	IN
cord-022290-p0l1kv6n	410	9	experimental	experimental	JJ
cord-022290-p0l1kv6n	410	10	information	information	NN
cord-022290-p0l1kv6n	410	11	available	available	JJ
cord-022290-p0l1kv6n	410	12	for	for	IN
cord-022290-p0l1kv6n	410	13	the	the	DT
cord-022290-p0l1kv6n	410	14	best	well	RBS
cord-022290-p0l1kv6n	410	15	-	-	HYPH
cord-022290-p0l1kv6n	410	16	studied	study	VBN
cord-022290-p0l1kv6n	410	17	examples	example	NNS
cord-022290-p0l1kv6n	410	18	of	of	IN
cord-022290-p0l1kv6n	410	19	the	the	DT
cord-022290-p0l1kv6n	410	20	viruses	virus	NNS
cord-022290-p0l1kv6n	410	21	of	of	IN
cord-022290-p0l1kv6n	410	22	the	the	DT
cord-022290-p0l1kv6n	410	23	Picornaviridae	Picornaviridae	NNP
cord-022290-p0l1kv6n	410	24	.	.	.
cord-022290-p0l1kv6n	411	1	This	this	DT
cord-022290-p0l1kv6n	411	2	information	information	NN
cord-022290-p0l1kv6n	411	3	provides	provide	VBZ
cord-022290-p0l1kv6n	411	4	an	an	DT
cord-022290-p0l1kv6n	411	5	opportunity	opportunity	NN
cord-022290-p0l1kv6n	411	6	to	to	TO
cord-022290-p0l1kv6n	411	7	design	design	VB
cord-022290-p0l1kv6n	411	8	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	411	9	against	against	IN
cord-022290-p0l1kv6n	411	10	the	the	DT
cord-022290-p0l1kv6n	411	11	viral	viral	JJ
cord-022290-p0l1kv6n	411	12	3C	3C	NNP
cord-022290-p0l1kv6n	411	13	proteinase	proteinase	NN
cord-022290-p0l1kv6n	411	14	.	.	.
cord-022290-p0l1kv6n	412	1	Effective	effective	JJ
cord-022290-p0l1kv6n	412	2	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	412	3	of	of	IN
cord-022290-p0l1kv6n	412	4	the	the	DT
cord-022290-p0l1kv6n	412	5	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	413	1	3C	3C	NNP
cord-022290-p0l1kv6n	413	2	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	413	3	have	have	VBP
cord-022290-p0l1kv6n	413	4	the	the	DT
cord-022290-p0l1kv6n	413	5	potential	potential	NN
cord-022290-p0l1kv6n	413	6	to	to	TO
cord-022290-p0l1kv6n	413	7	become	become	VB
cord-022290-p0l1kv6n	413	8	effective	effective	JJ
cord-022290-p0l1kv6n	413	9	antiviral	antiviral	JJ
cord-022290-p0l1kv6n	413	10	drugs	drug	NNS
cord-022290-p0l1kv6n	413	11	against	against	IN
cord-022290-p0l1kv6n	413	12	human	human	JJ
cord-022290-p0l1kv6n	413	13	diseases	disease	NNS
cord-022290-p0l1kv6n	413	14	such	such	JJ
cord-022290-p0l1kv6n	413	15	as	as	IN
cord-022290-p0l1kv6n	413	16	the	the	DT
cord-022290-p0l1kv6n	413	17	common	common	JJ
cord-022290-p0l1kv6n	413	18	cold	cold	NN
cord-022290-p0l1kv6n	413	19	,	,	,
cord-022290-p0l1kv6n	413	20	HAV	HAV	NNP
cord-022290-p0l1kv6n	413	21	,	,	,
cord-022290-p0l1kv6n	413	22	enteroviral	enteroviral	JJ
cord-022290-p0l1kv6n	413	23	infections	infection	NNS
cord-022290-p0l1kv6n	413	24	,	,	,
cord-022290-p0l1kv6n	413	25	and	and	CC
cord-022290-p0l1kv6n	413	26	diseases	disease	NNS
cord-022290-p0l1kv6n	413	27	caused	cause	VBN
cord-022290-p0l1kv6n	413	28	by	by	IN
cord-022290-p0l1kv6n	413	29	related	relate	VBN
cord-022290-p0l1kv6n	413	30	+	+	CC
cord-022290-p0l1kv6n	413	31	RNA	RNA	NNP
cord-022290-p0l1kv6n	413	32	viruses	virus	NNS
cord-022290-p0l1kv6n	413	33	.	.	.
cord-022290-p0l1kv6n	414	1	Picornaviral	Picornaviral	NNP
cord-022290-p0l1kv6n	414	2	3C	3C	NNP
cord-022290-p0l1kv6n	414	3	cysteine	cysteine	NN
cord-022290-p0l1kv6n	414	4	proteinases	proteinases	NNPS
cord-022290-p0l1kv6n	414	5	have	have	VBP
cord-022290-p0l1kv6n	414	6	a	a	DT
cord-022290-p0l1kv6n	414	7	fold	fold	NN
cord-022290-p0l1kv6n	414	8	similar	similar	JJ
cord-022290-p0l1kv6n	414	9	to	to	IN
cord-022290-p0l1kv6n	414	10	chymotrypsin	chymotrypsin	VB
cord-022290-p0l1kv6n	414	11	-	-	HYPH
cord-022290-p0l1kv6n	414	12	like	like	JJ
cord-022290-p0l1kv6n	414	13	serine	serine	NN
cord-022290-p0l1kv6n	414	14	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	415	1	Poliovirus	Poliovirus	NNP
cord-022290-p0l1kv6n	415	2	RNA	RNA	NNP
cord-022290-p0l1kv6n	415	3	synthesis	synthesis	NN
cord-022290-p0l1kv6n	415	4	utilizes	utilize	VBZ
cord-022290-p0l1kv6n	415	5	an	an	DT
cord-022290-p0l1kv6n	415	6	RNP	RNP	NNP
cord-022290-p0l1kv6n	415	7	complex	complex	NN
cord-022290-p0l1kv6n	415	8	formed	form	VBN
cord-022290-p0l1kv6n	415	9	around	around	IN
cord-022290-p0l1kv6n	415	10	the	the	DT
cord-022290-p0l1kv6n	415	11	5'-end	5'-end	CD
cord-022290-p0l1kv6n	415	12	of	of	IN
cord-022290-p0l1kv6n	415	13	viral	viral	JJ
cord-022290-p0l1kv6n	415	14	RNA	RNA	NNP
cord-022290-p0l1kv6n	415	15	Viral	Viral	NNP
cord-022290-p0l1kv6n	415	16	cysteine	cysteine	NN
cord-022290-p0l1kv6n	415	17	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	415	18	are	be	VBP
cord-022290-p0l1kv6n	415	19	homologous	homologous	JJ
cord-022290-p0l1kv6n	415	20	to	to	IN
cord-022290-p0l1kv6n	415	21	the	the	DT
cord-022290-p0l1kv6n	415	22	trypsinlike	trypsinlike	NN
cord-022290-p0l1kv6n	415	23	family	family	NN
cord-022290-p0l1kv6n	415	24	of	of	IN
cord-022290-p0l1kv6n	415	25	serine	serine	NNP
cord-022290-p0l1kv6n	415	26	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	415	27	:	:	:
cord-022290-p0l1kv6n	416	1	Structural	structural	JJ
cord-022290-p0l1kv6n	416	2	and	and	CC
cord-022290-p0l1kv6n	416	3	functional	functional	JJ
cord-022290-p0l1kv6n	416	4	implications	implication	NNS
cord-022290-p0l1kv6n	416	5	RNA	rna	NN
cord-022290-p0l1kv6n	416	6	-	-	HYPH
cord-022290-p0l1kv6n	416	7	protein	protein	NN
cord-022290-p0l1kv6n	416	8	interactions	interaction	NNS
cord-022290-p0l1kv6n	416	9	in	in	IN
cord-022290-p0l1kv6n	416	10	regulation	regulation	NN
cord-022290-p0l1kv6n	416	11	of	of	IN
cord-022290-p0l1kv6n	416	12	picornavirus	picornavirus	NNP
cord-022290-p0l1kv6n	416	13	RNA	RNA	NNP
cord-022290-p0l1kv6n	416	14	translation	translation	NN
cord-022290-p0l1kv6n	416	15	Handbook	Handbook	NNP
cord-022290-p0l1kv6n	416	16	of	of	IN
cord-022290-p0l1kv6n	416	17	Proteolytic	Proteolytic	NNP
cord-022290-p0l1kv6n	416	18	Enzymes	enzyme	NNS
cord-022290-p0l1kv6n	417	1	The	the	DT
cord-022290-p0l1kv6n	417	2	refined	refined	JJ
cord-022290-p0l1kv6n	417	3	crystal	crystal	NN
cord-022290-p0l1kv6n	417	4	structure	structure	NN
cord-022290-p0l1kv6n	417	5	of	of	IN
cord-022290-p0l1kv6n	417	6	the	the	DT
cord-022290-p0l1kv6n	417	7	3C	3C	NNP
cord-022290-p0l1kv6n	417	8	gene	gene	NN
cord-022290-p0l1kv6n	417	9	product	product	NN
cord-022290-p0l1kv6n	417	10	from	from	IN
cord-022290-p0l1kv6n	417	11	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	417	12	A	A	NNP
cord-022290-p0l1kv6n	417	13	virus	virus	NN
cord-022290-p0l1kv6n	417	14	:	:	:
cord-022290-p0l1kv6n	417	15	Specific	specific	JJ
cord-022290-p0l1kv6n	417	16	proteinase	proteinase	NN
cord-022290-p0l1kv6n	417	17	activity	activity	NN
cord-022290-p0l1kv6n	417	18	and	and	CC
cord-022290-p0l1kv6n	417	19	RNA	RNA	NNP
cord-022290-p0l1kv6n	417	20	recognition	recognition	NN
cord-022290-p0l1kv6n	417	21	Intracellular	Intracellular	NNP
cord-022290-p0l1kv6n	417	22	distribution	distribution	NN
cord-022290-p0l1kv6n	417	23	of	of	IN
cord-022290-p0l1kv6n	417	24	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	417	25	proteins	protein	NNS
cord-022290-p0l1kv6n	417	26	and	and	CC
cord-022290-p0l1kv6n	417	27	the	the	DT
cord-022290-p0l1kv6n	417	28	induction	induction	NN
cord-022290-p0l1kv6n	417	29	of	of	IN
cord-022290-p0l1kv6n	417	30	virus	virus	NN
cord-022290-p0l1kv6n	417	31	-	-	HYPH
cord-022290-p0l1kv6n	417	32	specific	specific	JJ
cord-022290-p0l1kv6n	417	33	cytoplasmic	cytoplasmic	JJ
cord-022290-p0l1kv6n	417	34	structures	structure	NNS
cord-022290-p0l1kv6n	418	1	Structural	structural	JJ
cord-022290-p0l1kv6n	418	2	organization	organization	NN
cord-022290-p0l1kv6n	418	3	of	of	IN
cord-022290-p0l1kv6n	418	4	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	418	5	RNA	RNA	NNP
cord-022290-p0l1kv6n	418	6	replication	replication	NN
cord-022290-p0l1kv6n	418	7	is	be	VBZ
cord-022290-p0l1kv6n	418	8	mediated	mediate	VBN
cord-022290-p0l1kv6n	418	9	by	by	IN
cord-022290-p0l1kv6n	418	10	viral	viral	JJ
cord-022290-p0l1kv6n	418	11	proteins	protein	NNS
cord-022290-p0l1kv6n	418	12	of	of	IN
cord-022290-p0l1kv6n	418	13	the	the	DT
cord-022290-p0l1kv6n	418	14	P2	P2	NNP
cord-022290-p0l1kv6n	418	15	genomic	genomic	JJ
cord-022290-p0l1kv6n	418	16	region	region	NN
cord-022290-p0l1kv6n	418	17	Natural	natural	JJ
cord-022290-p0l1kv6n	418	18	protein	protein	NN
cord-022290-p0l1kv6n	418	19	proteinase	proteinase	NN
cord-022290-p0l1kv6n	418	20	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	418	21	and	and	CC
cord-022290-p0l1kv6n	418	22	their	-PRON-	PRP$
cord-022290-p0l1kv6n	418	23	interactions	interaction	NNS
cord-022290-p0l1kv6n	418	24	with	with	IN
cord-022290-p0l1kv6n	418	25	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	418	26	Intact	intact	CC
cord-022290-p0l1kv6n	418	27	eukaryotic	eukaryotic	JJ
cord-022290-p0l1kv6n	418	28	initiation	initiation	NN
cord-022290-p0l1kv6n	418	29	factor	factor	NN
cord-022290-p0l1kv6n	418	30	4	4	CD
cord-022290-p0l1kv6n	418	31	G	g	NN
cord-022290-p0l1kv6n	418	32	is	be	VBZ
cord-022290-p0l1kv6n	418	33	required	require	VBN
cord-022290-p0l1kv6n	418	34	for	for	IN
cord-022290-p0l1kv6n	418	35	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	418	36	A	A	NNP
cord-022290-p0l1kv6n	418	37	virus	virus	NN
cord-022290-p0l1kv6n	418	38	internal	internal	JJ
cord-022290-p0l1kv6n	418	39	initiation	initiation	NN
cord-022290-p0l1kv6n	418	40	of	of	IN
cord-022290-p0l1kv6n	418	41	translation	translation	NN
cord-022290-p0l1kv6n	418	42	Novel	Novel	NNP
cord-022290-p0l1kv6n	418	43	triterpene	triterpene	NN
cord-022290-p0l1kv6n	418	44	sulfates	sulfate	NNS
cord-022290-p0l1kv6n	418	45	from	from	IN
cord-022290-p0l1kv6n	418	46	fusarium	fusarium	NN
cord-022290-p0l1kv6n	418	47	compactum	compactum	NNP
cord-022290-p0l1kv6n	418	48	using	use	VBG
cord-022290-p0l1kv6n	418	49	a	a	DT
cord-022290-p0l1kv6n	418	50	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	418	51	3C	3c	NN
cord-022290-p0l1kv6n	418	52	protease	protease	NN
cord-022290-p0l1kv6n	418	53	inhibitor	inhibitor	NN
cord-022290-p0l1kv6n	418	54	screen	screen	NN
cord-022290-p0l1kv6n	418	55	Functional	functional	JJ
cord-022290-p0l1kv6n	418	56	analysis	analysis	NN
cord-022290-p0l1kv6n	418	57	of	of	IN
cord-022290-p0l1kv6n	418	58	the	the	DT
cord-022290-p0l1kv6n	418	59	two	two	CD
cord-022290-p0l1kv6n	418	60	alternative	alternative	JJ
cord-022290-p0l1kv6n	418	61	initiation	initiation	NN
cord-022290-p0l1kv6n	418	62	sites	site	NNS
cord-022290-p0l1kv6n	418	63	of	of	IN
cord-022290-p0l1kv6n	418	64	foot	foot	NN
cord-022290-p0l1kv6n	418	65	-	-	HYPH
cord-022290-p0l1kv6n	418	66	and	and	CC
cord-022290-p0l1kv6n	418	67	-	-	HYPH
cord-022290-p0l1kv6n	418	68	mouth	mouth	NN
cord-022290-p0l1kv6n	418	69	disease	disease	NN
cord-022290-p0l1kv6n	418	70	virus	virus	NN
cord-022290-p0l1kv6n	418	71	Myocarditis	myocarditis	RB
cord-022290-p0l1kv6n	418	72	as	as	IN
cord-022290-p0l1kv6n	418	73	systemic	systemic	JJ
cord-022290-p0l1kv6n	418	74	disease	disease	NN
cord-022290-p0l1kv6n	418	75	:	:	:
cord-022290-p0l1kv6n	418	76	New	new	JJ
cord-022290-p0l1kv6n	418	77	perspectives	perspective	NNS
cord-022290-p0l1kv6n	418	78	on	on	IN
cord-022290-p0l1kv6n	418	79	pathogenesis	pathogenesis	NN
cord-022290-p0l1kv6n	418	80	Principles	principle	NNS
cord-022290-p0l1kv6n	418	81	that	that	WDT
cord-022290-p0l1kv6n	418	82	determine	determine	VBP
cord-022290-p0l1kv6n	418	83	the	the	DT
cord-022290-p0l1kv6n	418	84	structure	structure	NN
cord-022290-p0l1kv6n	418	85	of	of	IN
cord-022290-p0l1kv6n	418	86	proteins	protein	NNS
cord-022290-p0l1kv6n	418	87	Lippincott	Lippincott	NNP
cord-022290-p0l1kv6n	418	88	-	-	HYPH
cord-022290-p0l1kv6n	418	89	Raven	Raven	NNP
cord-022290-p0l1kv6n	418	90	A	a	DT
cord-022290-p0l1kv6n	418	91	protein	protein	NN
cord-022290-p0l1kv6n	418	92	linkage	linkage	NN
cord-022290-p0l1kv6n	418	93	map	map	NN
cord-022290-p0l1kv6n	418	94	of	of	IN
cord-022290-p0l1kv6n	418	95	the	the	DT
cord-022290-p0l1kv6n	418	96	P2	P2	NNP
cord-022290-p0l1kv6n	418	97	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	418	98	proteins	protein	NNS
cord-022290-p0l1kv6n	418	99	of	of	IN
cord-022290-p0l1kv6n	418	100	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	418	101	Expression	expression	NN
cord-022290-p0l1kv6n	418	102	and	and	CC
cord-022290-p0l1kv6n	418	103	purification	purification	NN
cord-022290-p0l1kv6n	418	104	of	of	IN
cord-022290-p0l1kv6n	418	105	recombinant	recombinant	JJ
cord-022290-p0l1kv6n	418	106	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	418	107	14	14	CD
cord-022290-p0l1kv6n	418	108	3CD	3cd	CD
cord-022290-p0l1kv6n	418	109	proteinase	proteinase	NN
cord-022290-p0l1kv6n	418	110	and	and	CC
cord-022290-p0l1kv6n	418	111	its	-PRON-	PRP$
cord-022290-p0l1kv6n	418	112	comparison	comparison	NN
cord-022290-p0l1kv6n	418	113	to	to	IN
cord-022290-p0l1kv6n	418	114	the	the	DT
cord-022290-p0l1kv6n	418	115	3C	3c	NN
cord-022290-p0l1kv6n	418	116	proteinase	proteinase	NN
cord-022290-p0l1kv6n	418	117	The	the	DT
cord-022290-p0l1kv6n	418	118	cleavage	cleavage	NN
cord-022290-p0l1kv6n	418	119	activity	activity	NN
cord-022290-p0l1kv6n	418	120	of	of	IN
cord-022290-p0l1kv6n	418	121	aphtho	aphtho	NNP
cord-022290-p0l1kv6n	418	122	and	and	CC
cord-022290-p0l1kv6n	418	123	cardiovirus	cardiovirus	NNP
cord-022290-p0l1kv6n	418	124	2A	2a	CD
cord-022290-p0l1kv6n	418	125	proteins	protein	NNS
cord-022290-p0l1kv6n	418	126	Expression	Expression	NNP
cord-022290-p0l1kv6n	418	127	of	of	IN
cord-022290-p0l1kv6n	418	128	virus	virus	NN
cord-022290-p0l1kv6n	418	129	-	-	HYPH
cord-022290-p0l1kv6n	418	130	encoded	encode	VBN
cord-022290-p0l1kv6n	418	131	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	418	132	:	:	:
cord-022290-p0l1kv6n	418	133	Functional	functional	JJ
cord-022290-p0l1kv6n	418	134	and	and	CC
cord-022290-p0l1kv6n	418	135	structural	structural	JJ
cord-022290-p0l1kv6n	418	136	similarities	similarity	NNS
cord-022290-p0l1kv6n	418	137	with	with	IN
cord-022290-p0l1kv6n	418	138	cellular	cellular	JJ
cord-022290-p0l1kv6n	418	139	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	418	140	Refined	refined	JJ
cord-022290-p0l1kv6n	418	141	crystal	crystal	NN
cord-022290-p0l1kv6n	418	142	structure	structure	NN
cord-022290-p0l1kv6n	418	143	of	of	IN
cord-022290-p0l1kv6n	418	144	c~-lytic	c~-lytic	JJ
cord-022290-p0l1kv6n	418	145	protease	protease	NN
cord-022290-p0l1kv6n	418	146	at	at	IN
cord-022290-p0l1kv6n	418	147	1.7	1.7	CD
cord-022290-p0l1kv6n	418	148	h	h	NN
cord-022290-p0l1kv6n	418	149	resolution	resolution	NN
cord-022290-p0l1kv6n	418	150	Two	two	CD
cord-022290-p0l1kv6n	418	151	functional	functional	JJ
cord-022290-p0l1kv6n	418	152	complexes	complex	NNS
cord-022290-p0l1kv6n	418	153	formed	form	VBN
cord-022290-p0l1kv6n	418	154	by	by	IN
cord-022290-p0l1kv6n	418	155	KH	KH	NNP
cord-022290-p0l1kv6n	418	156	domain	domain	NN
cord-022290-p0l1kv6n	418	157	containing	contain	VBG
cord-022290-p0l1kv6n	418	158	proteins	protein	NNS
cord-022290-p0l1kv6n	418	159	with	with	IN
cord-022290-p0l1kv6n	418	160	the	the	DT
cord-022290-p0l1kv6n	418	161	5	5	CD
cord-022290-p0l1kv6n	418	162	'	'	POS
cord-022290-p0l1kv6n	418	163	noncoding	noncoding	JJ
cord-022290-p0l1kv6n	418	164	region	region	NN
cord-022290-p0l1kv6n	418	165	of	of	IN
cord-022290-p0l1kv6n	418	166	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	418	167	RNA	RNA	NNP
cord-022290-p0l1kv6n	418	168	Viral	Viral	NNP
cord-022290-p0l1kv6n	418	169	cysteine	cysteine	NN
cord-022290-p0l1kv6n	418	170	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	419	1	Poliovirus	Poliovirus	NNP
cord-022290-p0l1kv6n	419	2	-	-	HYPH
cord-022290-p0l1kv6n	419	3	encoded	encode	VBN
cord-022290-p0l1kv6n	419	4	proteinase	proteinase	NN
cord-022290-p0l1kv6n	419	5	3C	3c	NN
cord-022290-p0l1kv6n	419	6	:	:	:
cord-022290-p0l1kv6n	419	7	A	a	DT
cord-022290-p0l1kv6n	419	8	possible	possible	JJ
cord-022290-p0l1kv6n	419	9	evolutionary	evolutionary	JJ
cord-022290-p0l1kv6n	419	10	link	link	NN
cord-022290-p0l1kv6n	419	11	between	between	IN
cord-022290-p0l1kv6n	419	12	cellular	cellular	JJ
cord-022290-p0l1kv6n	419	13	serine	serine	NN
cord-022290-p0l1kv6n	419	14	and	and	CC
cord-022290-p0l1kv6n	419	15	cysteine	cysteine	NN
cord-022290-p0l1kv6n	419	16	proteinase	proteinase	NN
cord-022290-p0l1kv6n	419	17	families	family	NNS
cord-022290-p0l1kv6n	419	18	Cysteine	cysteine	NN
cord-022290-p0l1kv6n	419	19	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	419	20	of	of	IN
cord-022290-p0l1kv6n	419	21	positive	positive	JJ
cord-022290-p0l1kv6n	419	22	strand	strand	NN
cord-022290-p0l1kv6n	419	23	RNA	RNA	NNP
cord-022290-p0l1kv6n	419	24	viruses	virus	NNS
cord-022290-p0l1kv6n	419	25	and	and	CC
cord-022290-p0l1kv6n	419	26	chymotrypsin	chymotrypsin	NN
cord-022290-p0l1kv6n	419	27	-	-	HYPH
cord-022290-p0l1kv6n	419	28	like	like	JJ
cord-022290-p0l1kv6n	419	29	serine	serine	NN
cord-022290-p0l1kv6n	419	30	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	419	31	:	:	:
cord-022290-p0l1kv6n	419	32	A	a	DT
cord-022290-p0l1kv6n	419	33	distinct	distinct	JJ
cord-022290-p0l1kv6n	419	34	protein	protein	NN
cord-022290-p0l1kv6n	419	35	superfamily	superfamily	NN
cord-022290-p0l1kv6n	419	36	with	with	IN
cord-022290-p0l1kv6n	419	37	a	a	DT
cord-022290-p0l1kv6n	419	38	common	common	JJ
cord-022290-p0l1kv6n	419	39	strcutural	strcutural	NN
cord-022290-p0l1kv6n	419	40	fold	fold	VB
cord-022290-p0l1kv6n	419	41	Putative	putative	JJ
cord-022290-p0l1kv6n	419	42	papain	papain	NN
cord-022290-p0l1kv6n	419	43	-	-	HYPH
cord-022290-p0l1kv6n	419	44	related	relate	VBN
cord-022290-p0l1kv6n	419	45	thiol	thiol	NN
cord-022290-p0l1kv6n	419	46	protease	protease	NN
cord-022290-p0l1kv6n	419	47	of	of	IN
cord-022290-p0l1kv6n	419	48	positive	positive	JJ
cord-022290-p0l1kv6n	419	49	strand	strand	NN
cord-022290-p0l1kv6n	419	50	RNA	rna	NN
cord-022290-p0l1kv6n	419	51	viruses	virus	NNS
cord-022290-p0l1kv6n	419	52	:	:	:
cord-022290-p0l1kv6n	419	53	Identification	identification	NN
cord-022290-p0l1kv6n	419	54	of	of	IN
cord-022290-p0l1kv6n	419	55	rubi	rubi	NNP
cord-022290-p0l1kv6n	419	56	-	-	HYPH
cord-022290-p0l1kv6n	419	57	and	and	CC
cord-022290-p0l1kv6n	419	58	aphthovirus	aphthovirus	NNP
cord-022290-p0l1kv6n	419	59	proteases	protease	NNS
cord-022290-p0l1kv6n	419	60	and	and	CC
cord-022290-p0l1kv6n	419	61	delineation	delineation	NN
cord-022290-p0l1kv6n	419	62	of	of	IN
cord-022290-p0l1kv6n	419	63	a	a	DT
cord-022290-p0l1kv6n	419	64	novel	novel	JJ
cord-022290-p0l1kv6n	419	65	conserved	conserve	VBN
cord-022290-p0l1kv6n	419	66	domain	domain	NN
cord-022290-p0l1kv6n	419	67	associated	associate	VBN
cord-022290-p0l1kv6n	419	68	with	with	IN
cord-022290-p0l1kv6n	419	69	proteases	protease	NNS
cord-022290-p0l1kv6n	419	70	of	of	IN
cord-022290-p0l1kv6n	419	71	rubi-	rubi-	NN
cord-022290-p0l1kv6n	419	72	,	,	,
cord-022290-p0l1kv6n	419	73	alpha	alpha	NN
cord-022290-p0l1kv6n	419	74	-	-	HYPH
cord-022290-p0l1kv6n	419	75	and	and	CC
cord-022290-p0l1kv6n	419	76	coronaviruses	coronaviruse	NNS
cord-022290-p0l1kv6n	419	77	Crystallization	Crystallization	NNP
cord-022290-p0l1kv6n	419	78	and	and	CC
cord-022290-p0l1kv6n	419	79	preliminary	preliminary	JJ
cord-022290-p0l1kv6n	419	80	X	x	NN
cord-022290-p0l1kv6n	419	81	-	-	NN
cord-022290-p0l1kv6n	419	82	ray	ray	NN
cord-022290-p0l1kv6n	419	83	diffraction	diffraction	NN
cord-022290-p0l1kv6n	419	84	studies	study	NNS
cord-022290-p0l1kv6n	419	85	of	of	IN
cord-022290-p0l1kv6n	419	86	the	the	DT
cord-022290-p0l1kv6n	419	87	Lb	Lb	NNP
cord-022290-p0l1kv6n	419	88	proteinase	proteinase	NN
cord-022290-p0l1kv6n	419	89	of	of	IN
cord-022290-p0l1kv6n	419	90	foot	foot	NN
cord-022290-p0l1kv6n	419	91	-	-	HYPH
cord-022290-p0l1kv6n	419	92	and	and	CC
cord-022290-p0l1kv6n	419	93	-	-	HYPH
cord-022290-p0l1kv6n	419	94	mouth	mouth	NN
cord-022290-p0l1kv6n	419	95	disease	disease	NN
cord-022290-p0l1kv6n	419	96	virus	virus	NN
cord-022290-p0l1kv6n	420	1	The	the	DT
cord-022290-p0l1kv6n	420	2	elF4G	elf4g	NN
cord-022290-p0l1kv6n	420	3	-	-	HYPH
cord-022290-p0l1kv6n	420	4	eIF4E	eif4e	CD
cord-022290-p0l1kv6n	420	5	complex	complex	NN
cord-022290-p0l1kv6n	420	6	is	be	VBZ
cord-022290-p0l1kv6n	420	7	the	the	DT
cord-022290-p0l1kv6n	420	8	target	target	NN
cord-022290-p0l1kv6n	420	9	for	for	IN
cord-022290-p0l1kv6n	420	10	direct	direct	JJ
cord-022290-p0l1kv6n	420	11	cleavage	cleavage	NN
cord-022290-p0l1kv6n	420	12	by	by	IN
cord-022290-p0l1kv6n	420	13	the	the	DT
cord-022290-p0l1kv6n	420	14	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	420	15	2A	2a	CD
cord-022290-p0l1kv6n	420	16	proteinase	proteinase	NN
cord-022290-p0l1kv6n	420	17	Mutational	Mutational	NNP
cord-022290-p0l1kv6n	420	18	analysis	analysis	NN
cord-022290-p0l1kv6n	420	19	of	of	IN
cord-022290-p0l1kv6n	420	20	the	the	DT
cord-022290-p0l1kv6n	420	21	proposed	propose	VBN
cord-022290-p0l1kv6n	420	22	FG	FG	NNP
cord-022290-p0l1kv6n	420	23	loop	loop	NN
cord-022290-p0l1kv6n	420	24	of	of	IN
cord-022290-p0l1kv6n	420	25	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	420	26	proteinase	proteinase	NN
cord-022290-p0l1kv6n	420	27	3C	3c	NN
cord-022290-p0l1kv6n	420	28	identified	identify	VBD
cord-022290-p0l1kv6n	420	29	amino	amino	JJ
cord-022290-p0l1kv6n	420	30	acids	acid	NNS
cord-022290-p0l1kv6n	420	31	that	that	WDT
cord-022290-p0l1kv6n	420	32	are	be	VBP
cord-022290-p0l1kv6n	420	33	necessary	necessary	JJ
cord-022290-p0l1kv6n	420	34	for	for	IN
cord-022290-p0l1kv6n	420	35	3CD	3cd	CD
cord-022290-p0l1kv6n	420	36	cleavage	cleavage	NN
cord-022290-p0l1kv6n	420	37	and	and	CC
cord-022290-p0l1kv6n	420	38	might	may	MD
cord-022290-p0l1kv6n	420	39	be	be	VB
cord-022290-p0l1kv6n	420	40	determinants	determinant	NNS
cord-022290-p0l1kv6n	420	41	of	of	IN
cord-022290-p0l1kv6n	420	42	a	a	DT
cord-022290-p0l1kv6n	420	43	function	function	NN
cord-022290-p0l1kv6n	420	44	distinct	distinct	JJ
cord-022290-p0l1kv6n	420	45	from	from	IN
cord-022290-p0l1kv6n	420	46	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	420	47	activity	activity	NN
cord-022290-p0l1kv6n	420	48	Expression	expression	NN
cord-022290-p0l1kv6n	420	49	of	of	IN
cord-022290-p0l1kv6n	420	50	a	a	DT
cord-022290-p0l1kv6n	420	51	cloned	clone	VBN
cord-022290-p0l1kv6n	420	52	gene	gene	NN
cord-022290-p0l1kv6n	420	53	segment	segment	NN
cord-022290-p0l1kv6n	420	54	of	of	IN
cord-022290-p0l1kv6n	420	55	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	420	56	in	in	IN
cord-022290-p0l1kv6n	420	57	E.	E.	NNP
cord-022290-p0l1kv6n	420	58	coli	coli	NNS
cord-022290-p0l1kv6n	420	59	:	:	:
cord-022290-p0l1kv6n	421	1	Evidence	evidence	NN
cord-022290-p0l1kv6n	421	2	for	for	IN
cord-022290-p0l1kv6n	421	3	autocatalytic	autocatalytic	JJ
cord-022290-p0l1kv6n	421	4	production	production	NN
cord-022290-p0l1kv6n	421	5	of	of	IN
cord-022290-p0l1kv6n	421	6	the	the	DT
cord-022290-p0l1kv6n	421	7	viral	viral	JJ
cord-022290-p0l1kv6n	421	8	proteinase	proteinase	NN
cord-022290-p0l1kv6n	421	9	Polyprotein	Polyprotein	NNP
cord-022290-p0l1kv6n	421	10	processing	processing	NN
cord-022290-p0l1kv6n	421	11	in	in	IN
cord-022290-p0l1kv6n	421	12	cis	cis	NNP
cord-022290-p0l1kv6n	421	13	and	and	CC
cord-022290-p0l1kv6n	421	14	in	in	IN
cord-022290-p0l1kv6n	421	15	trans	trans	NNP
cord-022290-p0l1kv6n	421	16	by	by	IN
cord-022290-p0l1kv6n	421	17	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	421	18	A	A	NNP
cord-022290-p0l1kv6n	421	19	virus	virus	NN
cord-022290-p0l1kv6n	421	20	3C	3c	NN
cord-022290-p0l1kv6n	421	21	protease	protease	NN
cord-022290-p0l1kv6n	421	22	cloned	clone	VBN
cord-022290-p0l1kv6n	421	23	and	and	CC
cord-022290-p0l1kv6n	421	24	expressed	express	VBN
cord-022290-p0l1kv6n	421	25	in	in	IN
cord-022290-p0l1kv6n	421	26	E.	E.	NNP
cord-022290-p0l1kv6n	421	27	coli	coli	VBZ
cord-022290-p0l1kv6n	421	28	Interactions	interaction	NNS
cord-022290-p0l1kv6n	421	29	of	of	IN
cord-022290-p0l1kv6n	421	30	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	421	31	polypeptide	polypeptide	NN
cord-022290-p0l1kv6n	421	32	3CD	3CD	NNP
cord-022290-p0l1kv6n	421	33	Pro	Pro	NNP
cord-022290-p0l1kv6n	421	34	with	with	IN
cord-022290-p0l1kv6n	421	35	the	the	DT
cord-022290-p0l1kv6n	421	36	5	5	CD
cord-022290-p0l1kv6n	421	37	'	'	''
cord-022290-p0l1kv6n	421	38	and	and	CC
cord-022290-p0l1kv6n	421	39	3	3	CD
cord-022290-p0l1kv6n	421	40	'	'	''
cord-022290-p0l1kv6n	421	41	termini	terminus	NNS
cord-022290-p0l1kv6n	421	42	of	of	IN
cord-022290-p0l1kv6n	421	43	the	the	DT
cord-022290-p0l1kv6n	421	44	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	421	45	genome	genome	NN
cord-022290-p0l1kv6n	421	46	Characterization	characterization	NN
cord-022290-p0l1kv6n	421	47	of	of	IN
cord-022290-p0l1kv6n	421	48	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	421	49	2A	2a	CD
cord-022290-p0l1kv6n	421	50	proteinase	proteinase	NN
cord-022290-p0l1kv6n	421	51	by	by	IN
cord-022290-p0l1kv6n	421	52	mutational	mutational	JJ
cord-022290-p0l1kv6n	421	53	analysis	analysis	NN
cord-022290-p0l1kv6n	421	54	:	:	:
cord-022290-p0l1kv6n	421	55	Residues	residue	NNS
cord-022290-p0l1kv6n	421	56	required	require	VBN
cord-022290-p0l1kv6n	421	57	for	for	IN
cord-022290-p0l1kv6n	421	58	autocatalytic	autocatalytic	JJ
cord-022290-p0l1kv6n	421	59	activity	activity	NN
cord-022290-p0l1kv6n	421	60	are	be	VBP
cord-022290-p0l1kv6n	421	61	essential	essential	JJ
cord-022290-p0l1kv6n	421	62	for	for	IN
cord-022290-p0l1kv6n	421	63	induction	induction	NN
cord-022290-p0l1kv6n	421	64	of	of	IN
cord-022290-p0l1kv6n	421	65	eukaryotic	eukaryotic	JJ
cord-022290-p0l1kv6n	421	66	initiation	initiation	NN
cord-022290-p0l1kv6n	421	67	factor	factor	NN
cord-022290-p0l1kv6n	421	68	4F	4F	NNP
cord-022290-p0l1kv6n	421	69	polypeptide	polypeptide	NN
cord-022290-p0l1kv6n	422	1	p220	p220	NNP
cord-022290-p0l1kv6n	422	2	Determinants	determinant	NNS
cord-022290-p0l1kv6n	422	3	of	of	IN
cord-022290-p0l1kv6n	422	4	substrate	substrate	NN
cord-022290-p0l1kv6n	422	5	recognition	recognition	NN
cord-022290-p0l1kv6n	422	6	by	by	IN
cord-022290-p0l1kv6n	422	7	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	422	8	2A	2a	CD
cord-022290-p0l1kv6n	422	9	proteinase	proteinase	NN
cord-022290-p0l1kv6n	423	1	Hepatitis	Hepatitis	NNP
cord-022290-p0l1kv6n	423	2	A	a	DT
cord-022290-p0l1kv6n	423	3	virus	virus	NN
cord-022290-p0l1kv6n	423	4	Convergence	convergence	NN
cord-022290-p0l1kv6n	423	5	of	of	IN
cord-022290-p0l1kv6n	423	6	active	active	JJ
cord-022290-p0l1kv6n	423	7	-	-	HYPH
cord-022290-p0l1kv6n	423	8	centre	centre	NN
cord-022290-p0l1kv6n	423	9	geometries	geometry	NNS
cord-022290-p0l1kv6n	423	10	among	among	IN
cord-022290-p0l1kv6n	423	11	the	the	DT
cord-022290-p0l1kv6n	423	12	proteolytic	proteolytic	JJ
cord-022290-p0l1kv6n	423	13	enzymes	enzyme	NNS
cord-022290-p0l1kv6n	423	14	Primary	primary	JJ
cord-022290-p0l1kv6n	423	15	cleavage	cleavage	NN
cord-022290-p0l1kv6n	423	16	of	of	IN
cord-022290-p0l1kv6n	423	17	the	the	DT
cord-022290-p0l1kv6n	423	18	HAV	HAV	NNP
cord-022290-p0l1kv6n	423	19	capsid	capsid	NN
cord-022290-p0l1kv6n	423	20	protein	protein	NN
cord-022290-p0l1kv6n	423	21	precursor	precursor	NN
cord-022290-p0l1kv6n	423	22	in	in	IN
cord-022290-p0l1kv6n	423	23	the	the	DT
cord-022290-p0l1kv6n	423	24	middle	middle	NN
cord-022290-p0l1kv6n	423	25	of	of	IN
cord-022290-p0l1kv6n	423	26	the	the	DT
cord-022290-p0l1kv6n	423	27	proposed	propose	VBN
cord-022290-p0l1kv6n	423	28	2A	2a	NN
cord-022290-p0l1kv6n	423	29	coding	code	VBG
cord-022290-p0l1kv6n	423	30	region	region	NN
cord-022290-p0l1kv6n	423	31	Viral	Viral	NNP
cord-022290-p0l1kv6n	423	32	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	423	33	:	:	:
cord-022290-p0l1kv6n	423	34	weakness	weakness	NN
cord-022290-p0l1kv6n	423	35	in	in	IN
cord-022290-p0l1kv6n	423	36	strength	strength	NN
cord-022290-p0l1kv6n	423	37	Foot	Foot	NNP
cord-022290-p0l1kv6n	423	38	-	-	HYPH
cord-022290-p0l1kv6n	423	39	and	and	CC
cord-022290-p0l1kv6n	423	40	-	-	HYPH
cord-022290-p0l1kv6n	423	41	mouth	mouth	NN
cord-022290-p0l1kv6n	423	42	disease	disease	NN
cord-022290-p0l1kv6n	423	43	virus	virus	NN
cord-022290-p0l1kv6n	423	44	leader	leader	NN
cord-022290-p0l1kv6n	423	45	proteinase	proteinase	NN
cord-022290-p0l1kv6n	423	46	:	:	:
cord-022290-p0l1kv6n	423	47	Purification	purification	NN
cord-022290-p0l1kv6n	423	48	of	of	IN
cord-022290-p0l1kv6n	423	49	the	the	DT
cord-022290-p0l1kv6n	423	50	Lb	Lb	NNP
cord-022290-p0l1kv6n	423	51	form	form	NN
cord-022290-p0l1kv6n	423	52	and	and	CC
cord-022290-p0l1kv6n	423	53	determination	determination	NN
cord-022290-p0l1kv6n	423	54	of	of	IN
cord-022290-p0l1kv6n	423	55	its	-PRON-	PRP$
cord-022290-p0l1kv6n	423	56	cleavage	cleavage	NN
cord-022290-p0l1kv6n	423	57	site	site	NN
cord-022290-p0l1kv6n	423	58	on	on	IN
cord-022290-p0l1kv6n	423	59	eIF47	eIF47	NNP
cord-022290-p0l1kv6n	423	60	Viral	Viral	NNP
cord-022290-p0l1kv6n	423	61	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	424	1	In	in	IN
cord-022290-p0l1kv6n	424	2	vitro	vitro	FW
cord-022290-p0l1kv6n	424	3	RNA	rna	NN
cord-022290-p0l1kv6n	424	4	binding	bind	VBG
cord-022290-p0l1kv6n	424	5	of	of	IN
cord-022290-p0l1kv6n	424	6	the	the	DT
cord-022290-p0l1kv6n	424	7	hepatitis	hepatitis	NN
cord-022290-p0l1kv6n	424	8	A	A	NNP
cord-022290-p0l1kv6n	424	9	virus	virus	NN
cord-022290-p0l1kv6n	424	10	proteinase	proteinase	NN
cord-022290-p0l1kv6n	424	11	3C	3c	NN
cord-022290-p0l1kv6n	424	12	(	(	-LRB-
cord-022290-p0l1kv6n	424	13	HAV	HAV	NNP
cord-022290-p0l1kv6n	424	14	3C	3C	NNP
cord-022290-p0l1kv6n	424	15	Pr~	Pr~	NNP
cord-022290-p0l1kv6n	424	16	to	to	IN
cord-022290-p0l1kv6n	424	17	secondary	secondary	JJ
cord-022290-p0l1kv6n	424	18	structure	structure	NN
cord-022290-p0l1kv6n	424	19	elements	element	NNS
cord-022290-p0l1kv6n	424	20	within	within	IN
cord-022290-p0l1kv6n	424	21	the	the	DT
cord-022290-p0l1kv6n	424	22	5	5	CD
cord-022290-p0l1kv6n	424	23	'	'	''
cord-022290-p0l1kv6n	424	24	terminus	terminus	NN
cord-022290-p0l1kv6n	424	25	of	of	IN
cord-022290-p0l1kv6n	424	26	the	the	DT
cord-022290-p0l1kv6n	424	27	HAV	HAV	NNP
cord-022290-p0l1kv6n	424	28	genome	genome	NN
cord-022290-p0l1kv6n	424	29	Mapping	mapping	NN
cord-022290-p0l1kv6n	424	30	the	the	DT
cord-022290-p0l1kv6n	424	31	cleavage	cleavage	NN
cord-022290-p0l1kv6n	424	32	site	site	NN
cord-022290-p0l1kv6n	424	33	in	in	IN
cord-022290-p0l1kv6n	424	34	protein	protein	NN
cord-022290-p0l1kv6n	424	35	synthesis	synthesis	NN
cord-022290-p0l1kv6n	424	36	initiation	initiation	NN
cord-022290-p0l1kv6n	424	37	factor	factor	NN
cord-022290-p0l1kv6n	424	38	elF-47	elf-47	NN
cord-022290-p0l1kv6n	424	39	of	of	IN
cord-022290-p0l1kv6n	424	40	the	the	DT
cord-022290-p0l1kv6n	424	41	2A	2a	CD
cord-022290-p0l1kv6n	424	42	proteases	protease	NNS
cord-022290-p0l1kv6n	424	43	from	from	IN
cord-022290-p0l1kv6n	424	44	human	human	JJ
cord-022290-p0l1kv6n	424	45	coxsackie	coxsackie	NNP
cord-022290-p0l1kv6n	424	46	virus	virus	NN
cord-022290-p0l1kv6n	424	47	and	and	CC
cord-022290-p0l1kv6n	424	48	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	424	49	Human	Human	NNP
cord-022290-p0l1kv6n	424	50	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	425	1	14	14	CD
cord-022290-p0l1kv6n	425	2	protease	protease	NN
cord-022290-p0l1kv6n	425	3	3C	3C	NNP
cord-022290-p0l1kv6n	425	4	(	(	-LRB-
cord-022290-p0l1kv6n	425	5	3C	3C	NNP
cord-022290-p0l1kv6n	425	6	Pr~	Pr~	NNP
cord-022290-p0l1kv6n	425	7	binds	bind	VBZ
cord-022290-p0l1kv6n	425	8	specifically	specifically	RB
cord-022290-p0l1kv6n	425	9	to	to	IN
cord-022290-p0l1kv6n	425	10	the	the	DT
cord-022290-p0l1kv6n	425	11	5'-noncoding	5'-noncoding	NNP
cord-022290-p0l1kv6n	425	12	region	region	NN
cord-022290-p0l1kv6n	425	13	of	of	IN
cord-022290-p0l1kv6n	425	14	the	the	DT
cord-022290-p0l1kv6n	425	15	viral	viral	JJ
cord-022290-p0l1kv6n	425	16	RNA	RNA	NNP
cord-022290-p0l1kv6n	425	17	A	a	DT
cord-022290-p0l1kv6n	425	18	consensus	consensus	NN
cord-022290-p0l1kv6n	425	19	sequence	sequence	NN
cord-022290-p0l1kv6n	425	20	for	for	IN
cord-022290-p0l1kv6n	425	21	substrate	substrate	JJ
cord-022290-p0l1kv6n	425	22	hydrolysis	hydrolysis	NN
cord-022290-p0l1kv6n	425	23	by	by	IN
cord-022290-p0l1kv6n	425	24	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	425	25	3C	3C	NNP
cord-022290-p0l1kv6n	425	26	proteinase	proteinase	NNP
cord-022290-p0l1kv6n	425	27	Analysis	Analysis	NNP
cord-022290-p0l1kv6n	425	28	of	of	IN
cord-022290-p0l1kv6n	425	29	picornavirus	picornavirus	NNP
cord-022290-p0l1kv6n	425	30	2A	2A	NNP
cord-022290-p0l1kv6n	425	31	(	(	-LRB-
cord-022290-p0l1kv6n	425	32	pro	pro	NNP
cord-022290-p0l1kv6n	425	33	)	)	-RRB-
cord-022290-p0l1kv6n	425	34	proteins	protein	NNS
cord-022290-p0l1kv6n	425	35	:	:	:
cord-022290-p0l1kv6n	426	1	Separation	separation	NN
cord-022290-p0l1kv6n	426	2	of	of	IN
cord-022290-p0l1kv6n	426	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	426	4	from	from	IN
cord-022290-p0l1kv6n	426	5	translation	translation	NN
cord-022290-p0l1kv6n	426	6	and	and	CC
cord-022290-p0l1kv6n	426	7	replication	replication	NN
cord-022290-p0l1kv6n	426	8	functions	function	NNS
cord-022290-p0l1kv6n	427	1	The	the	DT
cord-022290-p0l1kv6n	427	2	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	427	3	3C	3C	NNP
cord-022290-p0l1kv6n	427	4	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	427	5	:	:	:
cord-022290-p0l1kv6n	428	1	Cysteine	cysteine	NN
cord-022290-p0l1kv6n	428	2	nucleophiles	nucleophile	NNS
cord-022290-p0l1kv6n	428	3	in	in	IN
cord-022290-p0l1kv6n	428	4	serine	serine	NN
cord-022290-p0l1kv6n	428	5	proteinase	proteinase	NN
cord-022290-p0l1kv6n	428	6	folds	fold	VBZ
cord-022290-p0l1kv6n	428	7	Processing	processing	NN
cord-022290-p0l1kv6n	428	8	of	of	IN
cord-022290-p0l1kv6n	428	9	rabbit	rabbit	NN
cord-022290-p0l1kv6n	428	10	hemorrhagic	hemorrhagic	JJ
cord-022290-p0l1kv6n	428	11	disease	disease	NNP
cord-022290-p0l1kv6n	428	12	virus	virus	NN
cord-022290-p0l1kv6n	428	13	polyprotein	polyprotein	NNP
cord-022290-p0l1kv6n	428	14	Identification	Identification	NNP
cord-022290-p0l1kv6n	428	15	and	and	CC
cord-022290-p0l1kv6n	428	16	site	site	NN
cord-022290-p0l1kv6n	428	17	-	-	HYPH
cord-022290-p0l1kv6n	428	18	directed	direct	VBN
cord-022290-p0l1kv6n	428	19	mutagenesis	mutagenesis	NN
cord-022290-p0l1kv6n	428	20	of	of	IN
cord-022290-p0l1kv6n	428	21	the	the	DT
cord-022290-p0l1kv6n	428	22	primary	primary	JJ
cord-022290-p0l1kv6n	428	23	(	(	-LRB-
cord-022290-p0l1kv6n	428	24	2A/2B	2a/2b	CD
cord-022290-p0l1kv6n	428	25	)	)	-RRB-
cord-022290-p0l1kv6n	428	26	cleavage	cleavage	NN
cord-022290-p0l1kv6n	428	27	site	site	NN
cord-022290-p0l1kv6n	428	28	of	of	IN
cord-022290-p0l1kv6n	428	29	the	the	DT
cord-022290-p0l1kv6n	428	30	hepatitis	hepatitis	NN
cord-022290-p0l1kv6n	428	31	A	A	NNP
cord-022290-p0l1kv6n	428	32	virus	virus	NN
cord-022290-p0l1kv6n	428	33	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	428	34	:	:	:
cord-022290-p0l1kv6n	428	35	Functional	functional	JJ
cord-022290-p0l1kv6n	428	36	impact	impact	NN
cord-022290-p0l1kv6n	428	37	on	on	IN
cord-022290-p0l1kv6n	428	38	the	the	DT
cord-022290-p0l1kv6n	428	39	infectivity	infectivity	NN
cord-022290-p0l1kv6n	428	40	of	of	IN
cord-022290-p0l1kv6n	428	41	HAV	HAV	NNP
cord-022290-p0l1kv6n	428	42	RNA	RNA	NNP
cord-022290-p0l1kv6n	428	43	transcripts	transcripts	NNPS
cord-022290-p0l1kv6n	428	44	Structure	Structure	NNP
cord-022290-p0l1kv6n	428	45	of	of	IN
cord-022290-p0l1kv6n	428	46	human	human	JJ
cord-022290-p0l1kv6n	428	47	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	428	48	3C	3C	NNP
cord-022290-p0l1kv6n	428	49	protease	protease	NNP
cord-022290-p0l1kv6n	428	50	reveals	reveal	VBZ
cord-022290-p0l1kv6n	428	51	a	a	DT
cord-022290-p0l1kv6n	428	52	trypsin	trypsin	NN
cord-022290-p0l1kv6n	428	53	-	-	HYPH
cord-022290-p0l1kv6n	428	54	like	like	JJ
cord-022290-p0l1kv6n	428	55	polypeptide	polypeptide	NN
cord-022290-p0l1kv6n	428	56	fold	fold	VBG
cord-022290-p0l1kv6n	428	57	,	,	,
cord-022290-p0l1kv6n	428	58	RNA	rna	NN
cord-022290-p0l1kv6n	428	59	-	-	HYPH
cord-022290-p0l1kv6n	428	60	binding	bind	VBG
cord-022290-p0l1kv6n	428	61	site	site	NN
cord-022290-p0l1kv6n	428	62	and	and	CC
cord-022290-p0l1kv6n	428	63	means	mean	VBZ
cord-022290-p0l1kv6n	428	64	for	for	IN
cord-022290-p0l1kv6n	428	65	cleaving	cleave	VBG
cord-022290-p0l1kv6n	428	66	precursor	precursor	NN
cord-022290-p0l1kv6n	428	67	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	429	1	The	the	DT
cord-022290-p0l1kv6n	429	2	two	two	CD
cord-022290-p0l1kv6n	429	3	species	specie	NNS
cord-022290-p0l1kv6n	429	4	of	of	IN
cord-022290-p0l1kv6n	429	5	the	the	DT
cord-022290-p0l1kv6n	429	6	footand	footand	NN
cord-022290-p0l1kv6n	429	7	-	-	HYPH
cord-022290-p0l1kv6n	429	8	mouth	mouth	NN
cord-022290-p0l1kv6n	429	9	disease	disease	NN
cord-022290-p0l1kv6n	429	10	virus	virus	NN
cord-022290-p0l1kv6n	429	11	leader	leader	NN
cord-022290-p0l1kv6n	429	12	protein	protein	NN
cord-022290-p0l1kv6n	429	13	expressed	express	VBD
cord-022290-p0l1kv6n	429	14	individually	individually	RB
cord-022290-p0l1kv6n	429	15	,	,	,
cord-022290-p0l1kv6n	429	16	exhibit	exhibit	VB
cord-022290-p0l1kv6n	429	17	the	the	DT
cord-022290-p0l1kv6n	429	18	same	same	JJ
cord-022290-p0l1kv6n	429	19	activities	activity	NNS
cord-022290-p0l1kv6n	430	1	Enteroviruses	Enteroviruses	NNP
cord-022290-p0l1kv6n	430	2	:	:	:
cord-022290-p0l1kv6n	431	1	Polioviruses	Polioviruses	NNP
cord-022290-p0l1kv6n	431	2	coxsackie	coxsackie	VBP
cord-022290-p0l1kv6n	431	3	viruses	virus	NNS
cord-022290-p0l1kv6n	431	4	,	,	,
cord-022290-p0l1kv6n	431	5	echoviruses	echovirus	NNS
cord-022290-p0l1kv6n	431	6	,	,	,
cord-022290-p0l1kv6n	431	7	and	and	CC
cord-022290-p0l1kv6n	431	8	newer	new	JJR
cord-022290-p0l1kv6n	431	9	enteroviruses	enterovirus	NNS
cord-022290-p0l1kv6n	431	10	Persistent	persistent	JJ
cord-022290-p0l1kv6n	431	11	infection	infection	NN
cord-022290-p0l1kv6n	431	12	with	with	IN
cord-022290-p0l1kv6n	431	13	Theiler	Theiler	NNP
cord-022290-p0l1kv6n	431	14	's	's	POS
cord-022290-p0l1kv6n	431	15	virus	virus	NN
cord-022290-p0l1kv6n	431	16	leads	lead	VBZ
cord-022290-p0l1kv6n	431	17	to	to	IN
cord-022290-p0l1kv6n	431	18	CNS	CNS	NNP
cord-022290-p0l1kv6n	431	19	autoimmunity	autoimmunity	NN
cord-022290-p0l1kv6n	431	20	via	via	IN
cord-022290-p0l1kv6n	431	21	epitope	epitope	NN
cord-022290-p0l1kv6n	431	22	spreading	spread	VBG
cord-022290-p0l1kv6n	431	23	Studies	Studies	NNP
cord-022290-p0l1kv6n	431	24	on	on	IN
cord-022290-p0l1kv6n	431	25	dicistronic	dicistronic	NNP
cord-022290-p0l1kv6n	431	26	polioviruses	poliovirus	NNS
cord-022290-p0l1kv6n	432	1	implicate	implicate	VB
cord-022290-p0l1kv6n	432	2	viral	viral	JJ
cord-022290-p0l1kv6n	432	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	432	4	2A	2a	CD
cord-022290-p0l1kv6n	432	5	vr~	vr~	NN
cord-022290-p0l1kv6n	432	6	in	in	IN
cord-022290-p0l1kv6n	432	7	RNA	RNA	NNP
cord-022290-p0l1kv6n	432	8	replication	replication	NN
cord-022290-p0l1kv6n	433	1	In	in	IN
cord-022290-p0l1kv6n	433	2	vitro	vitro	FW
cord-022290-p0l1kv6n	433	3	and	and	CC
cord-022290-p0l1kv6n	433	4	ex	ex	FW
cord-022290-p0l1kv6n	433	5	vivo	vivo	NN
cord-022290-p0l1kv6n	433	6	inhibition	inhibition	NN
cord-022290-p0l1kv6n	433	7	of	of	IN
cord-022290-p0l1kv6n	433	8	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	433	9	A	A	NNP
cord-022290-p0l1kv6n	433	10	virus	virus	NN
cord-022290-p0l1kv6n	433	11	3C	3c	NN
cord-022290-p0l1kv6n	433	12	proteinase	proteinase	NN
cord-022290-p0l1kv6n	433	13	by	by	IN
cord-022290-p0l1kv6n	433	14	a	a	DT
cord-022290-p0l1kv6n	433	15	peptidyl	peptidyl	JJ
cord-022290-p0l1kv6n	433	16	monofluoromethyl	monofluoromethyl	NN
cord-022290-p0l1kv6n	433	17	ketone	ketone	NN
cord-022290-p0l1kv6n	433	18	Refined	Refined	NNP
cord-022290-p0l1kv6n	433	19	X	X	NNP
cord-022290-p0l1kv6n	433	20	-	-	NN
cord-022290-p0l1kv6n	433	21	ray	ray	NN
cord-022290-p0l1kv6n	433	22	crystallographic	crystallographic	JJ
cord-022290-p0l1kv6n	433	23	structure	structure	NN
cord-022290-p0l1kv6n	433	24	of	of	IN
cord-022290-p0l1kv6n	433	25	the	the	DT
cord-022290-p0l1kv6n	433	26	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	433	27	3C	3C	NNP
cord-022290-p0l1kv6n	433	28	gene	gene	NN
cord-022290-p0l1kv6n	433	29	product	product	NN
cord-022290-p0l1kv6n	433	30	Poliovirus	Poliovirus	NNP
cord-022290-p0l1kv6n	433	31	proteinase	proteinase	NN
cord-022290-p0l1kv6n	433	32	3C	3c	NN
cord-022290-p0l1kv6n	433	33	:	:	:
cord-022290-p0l1kv6n	433	34	Largescale	largescale	JJ
cord-022290-p0l1kv6n	433	35	expression	expression	NN
cord-022290-p0l1kv6n	433	36	,	,	,
cord-022290-p0l1kv6n	433	37	purification	purification	NN
cord-022290-p0l1kv6n	433	38	and	and	CC
cord-022290-p0l1kv6n	433	39	specific	specific	JJ
cord-022290-p0l1kv6n	433	40	cleavage	cleavage	NN
cord-022290-p0l1kv6n	433	41	activity	activity	NN
cord-022290-p0l1kv6n	433	42	on	on	IN
cord-022290-p0l1kv6n	433	43	natural	natural	JJ
cord-022290-p0l1kv6n	433	44	and	and	CC
cord-022290-p0l1kv6n	433	45	synthetic	synthetic	JJ
cord-022290-p0l1kv6n	433	46	substrates	substrate	NNS
cord-022290-p0l1kv6n	433	47	in	in	IN
cord-022290-p0l1kv6n	433	48	vitro	vitro	FW
cord-022290-p0l1kv6n	433	49	Cleavage	cleavage	NN
cord-022290-p0l1kv6n	433	50	of	of	IN
cord-022290-p0l1kv6n	433	51	synthetic	synthetic	JJ
cord-022290-p0l1kv6n	433	52	peptides	peptide	NNS
cord-022290-p0l1kv6n	433	53	by	by	IN
cord-022290-p0l1kv6n	433	54	purified	purify	VBN
cord-022290-p0l1kv6n	433	55	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	433	56	3C	3c	NN
cord-022290-p0l1kv6n	433	57	proteinase	proteinase	NN
cord-022290-p0l1kv6n	433	58	Proteolytic	Proteolytic	NNP
cord-022290-p0l1kv6n	433	59	processing	processing	NN
cord-022290-p0l1kv6n	433	60	of	of	IN
cord-022290-p0l1kv6n	433	61	picornaviral	picornaviral	NNP
cord-022290-p0l1kv6n	433	62	polyprotein	polyprotein	NNP
cord-022290-p0l1kv6n	433	63	Evidence	Evidence	NNP
cord-022290-p0l1kv6n	433	64	for	for	IN
cord-022290-p0l1kv6n	433	65	intramolecular	intramolecular	JJ
cord-022290-p0l1kv6n	433	66	self	self	NN
cord-022290-p0l1kv6n	433	67	-	-	HYPH
cord-022290-p0l1kv6n	433	68	cleavage	cleavage	NN
cord-022290-p0l1kv6n	433	69	of	of	IN
cord-022290-p0l1kv6n	433	70	picornaviral	picornaviral	JJ
cord-022290-p0l1kv6n	433	71	replicase	replicase	NN
cord-022290-p0l1kv6n	433	72	precursors	precursor	NNS
cord-022290-p0l1kv6n	433	73	Proteolytic	Proteolytic	NNP
cord-022290-p0l1kv6n	433	74	processing	processing	NN
cord-022290-p0l1kv6n	433	75	of	of	IN
cord-022290-p0l1kv6n	433	76	the	the	DT
cord-022290-p0l1kv6n	433	77	cardioviral	cardioviral	NNP
cord-022290-p0l1kv6n	433	78	P2	P2	NNP
cord-022290-p0l1kv6n	433	79	region	region	NN
cord-022290-p0l1kv6n	433	80	:	:	:
cord-022290-p0l1kv6n	433	81	Primary	primary	JJ
cord-022290-p0l1kv6n	433	82	2A/2B	2a/2b	CD
cord-022290-p0l1kv6n	433	83	cleavage	cleavage	NN
cord-022290-p0l1kv6n	433	84	in	in	IN
cord-022290-p0l1kv6n	433	85	clone	clone	NN
cord-022290-p0l1kv6n	433	86	derived	derive	VBN
cord-022290-p0l1kv6n	433	87	precursors	precursor	NNS
cord-022290-p0l1kv6n	433	88	Poly	Poly	NNP
cord-022290-p0l1kv6n	433	89	(	(	-LRB-
cord-022290-p0l1kv6n	433	90	rC	rc	NN
cord-022290-p0l1kv6n	433	91	)	)	-RRB-
cord-022290-p0l1kv6n	433	92	binding	bind	VBG
cord-022290-p0l1kv6n	433	93	protein	protein	NN
cord-022290-p0l1kv6n	433	94	2	2	CD
cord-022290-p0l1kv6n	433	95	forms	form	NNS
cord-022290-p0l1kv6n	433	96	a	a	DT
cord-022290-p0l1kv6n	433	97	ternary	ternary	JJ
cord-022290-p0l1kv6n	433	98	complex	complex	NN
cord-022290-p0l1kv6n	433	99	with	with	IN
cord-022290-p0l1kv6n	433	100	the	the	DT
cord-022290-p0l1kv6n	433	101	5'-terminal	5'-terminal	NNP
cord-022290-p0l1kv6n	433	102	sequences	sequence	NNS
cord-022290-p0l1kv6n	433	103	of	of	IN
cord-022290-p0l1kv6n	433	104	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	433	105	RNA	RNA	NNP
cord-022290-p0l1kv6n	433	106	and	and	CC
cord-022290-p0l1kv6n	433	107	the	the	DT
cord-022290-p0l1kv6n	433	108	viral	viral	JJ
cord-022290-p0l1kv6n	433	109	3CD	3cd	CD
cord-022290-p0l1kv6n	433	110	proteinase	proteinase	NN
cord-022290-p0l1kv6n	433	111	Structural	structural	JJ
cord-022290-p0l1kv6n	433	112	basis	basis	NN
cord-022290-p0l1kv6n	433	113	of	of	IN
cord-022290-p0l1kv6n	433	114	substrate	substrate	JJ
cord-022290-p0l1kv6n	433	115	specificity	specificity	NN
cord-022290-p0l1kv6n	433	116	in	in	IN
cord-022290-p0l1kv6n	433	117	the	the	DT
cord-022290-p0l1kv6n	433	118	serine	serine	NN
cord-022290-p0l1kv6n	433	119	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	434	1	The	the	DT
cord-022290-p0l1kv6n	434	2	foot	foot	NN
cord-022290-p0l1kv6n	434	3	-	-	HYPH
cord-022290-p0l1kv6n	434	4	and	and	CC
cord-022290-p0l1kv6n	434	5	-	-	HYPH
cord-022290-p0l1kv6n	434	6	mouth	mouth	NN
cord-022290-p0l1kv6n	434	7	disease	disease	NN
cord-022290-p0l1kv6n	434	8	leader	leader	NN
cord-022290-p0l1kv6n	434	9	proteinase	proteinase	NN
cord-022290-p0l1kv6n	434	10	gene	gene	NN
cord-022290-p0l1kv6n	434	11	is	be	VBZ
cord-022290-p0l1kv6n	434	12	not	not	RB
cord-022290-p0l1kv6n	434	13	required	require	VBN
cord-022290-p0l1kv6n	434	14	for	for	IN
cord-022290-p0l1kv6n	434	15	viral	viral	JJ
cord-022290-p0l1kv6n	434	16	replication	replication	NN
cord-022290-p0l1kv6n	434	17	Identification	identification	NN
cord-022290-p0l1kv6n	434	18	of	of	IN
cord-022290-p0l1kv6n	434	19	the	the	DT
cord-022290-p0l1kv6n	434	20	active	active	JJ
cord-022290-p0l1kv6n	434	21	-	-	HYPH
cord-022290-p0l1kv6n	434	22	site	site	NN
cord-022290-p0l1kv6n	434	23	residues	residue	NNS
cord-022290-p0l1kv6n	434	24	of	of	IN
cord-022290-p0l1kv6n	434	25	the	the	DT
cord-022290-p0l1kv6n	434	26	L	L	NNP
cord-022290-p0l1kv6n	434	27	proteinase	proteinase	NN
cord-022290-p0l1kv6n	434	28	of	of	IN
cord-022290-p0l1kv6n	434	29	foot	foot	NN
cord-022290-p0l1kv6n	434	30	-	-	HYPH
cord-022290-p0l1kv6n	434	31	and	and	CC
cord-022290-p0l1kv6n	434	32	-	-	HYPH
cord-022290-p0l1kv6n	434	33	mouth	mouth	NN
cord-022290-p0l1kv6n	434	34	disease	disease	NN
cord-022290-p0l1kv6n	434	35	virus	virus	NN
cord-022290-p0l1kv6n	434	36	Picornavirus	Picornavirus	NNP
cord-022290-p0l1kv6n	434	37	nonstructural	nonstructural	JJ
cord-022290-p0l1kv6n	434	38	proteins	protein	NNS
cord-022290-p0l1kv6n	434	39	:	:	:
cord-022290-p0l1kv6n	434	40	Emerging	emerge	VBG
cord-022290-p0l1kv6n	434	41	roles	role	NNS
cord-022290-p0l1kv6n	434	42	in	in	IN
cord-022290-p0l1kv6n	434	43	virus	virus	NN
cord-022290-p0l1kv6n	434	44	replication	replication	NN
cord-022290-p0l1kv6n	434	45	and	and	CC
cord-022290-p0l1kv6n	434	46	inhibition	inhibition	NN
cord-022290-p0l1kv6n	434	47	of	of	IN
cord-022290-p0l1kv6n	434	48	host	host	NN
cord-022290-p0l1kv6n	434	49	cell	cell	NN
cord-022290-p0l1kv6n	434	50	functions	function	NNS
cord-022290-p0l1kv6n	434	51	Small	small	JJ
cord-022290-p0l1kv6n	434	52	synthetic	synthetic	JJ
cord-022290-p0l1kv6n	434	53	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	434	54	of	of	IN
cord-022290-p0l1kv6n	434	55	cysteine	cysteine	NN
cord-022290-p0l1kv6n	434	56	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	434	57	Introduction	Introduction	NNP
cord-022290-p0l1kv6n	434	58	to	to	IN
cord-022290-p0l1kv6n	434	59	the	the	DT
cord-022290-p0l1kv6n	434	60	Protein	Protein	NNP
cord-022290-p0l1kv6n	434	61	Inhibitors	Inhibitors	NNP
cord-022290-p0l1kv6n	434	62	:	:	:
cord-022290-p0l1kv6n	434	63	X	x	NN
cord-022290-p0l1kv6n	434	64	-	-	NN
cord-022290-p0l1kv6n	434	65	ray	ray	NN
cord-022290-p0l1kv6n	434	66	Crystallography	Crystallography	NNP
cord-022290-p0l1kv6n	434	67	Identification	identification	NN
cord-022290-p0l1kv6n	434	68	of	of	IN
cord-022290-p0l1kv6n	434	69	critical	critical	JJ
cord-022290-p0l1kv6n	434	70	amino	amino	NN
cord-022290-p0l1kv6n	434	71	acids	acid	NNS
cord-022290-p0l1kv6n	434	72	within	within	IN
cord-022290-p0l1kv6n	434	73	the	the	DT
cord-022290-p0l1kv6n	434	74	foot	foot	NN
cord-022290-p0l1kv6n	434	75	-	-	HYPH
cord-022290-p0l1kv6n	434	76	andmouth	andmouth	NNP
cord-022290-p0l1kv6n	434	77	disease	disease	NNP
cord-022290-p0l1kv6n	434	78	virus	virus	NN
cord-022290-p0l1kv6n	434	79	leader	leader	NN
cord-022290-p0l1kv6n	434	80	protein	protein	NN
cord-022290-p0l1kv6n	434	81	,	,	,
cord-022290-p0l1kv6n	434	82	a	a	DT
cord-022290-p0l1kv6n	434	83	cysteine	cysteine	NN
cord-022290-p0l1kv6n	434	84	protease	protease	NN
cord-022290-p0l1kv6n	434	85	Picornaviridae	Picornaviridae	NNP
cord-022290-p0l1kv6n	434	86	:	:	:
cord-022290-p0l1kv6n	435	1	The	the	DT
cord-022290-p0l1kv6n	435	2	Viruses	virus	NNS
cord-022290-p0l1kv6n	435	3	and	and	CC
cord-022290-p0l1kv6n	435	4	their	-PRON-	PRP$
cord-022290-p0l1kv6n	435	5	Replication	Replication	NNP
cord-022290-p0l1kv6n	435	6	Virus	virus	NN
cord-022290-p0l1kv6n	435	7	-	-	HYPH
cord-022290-p0l1kv6n	435	8	encoded	encode	VBN
cord-022290-p0l1kv6n	435	9	proteinases	proteinase	NNS
cord-022290-p0l1kv6n	435	10	of	of	IN
cord-022290-p0l1kv6n	435	11	the	the	DT
cord-022290-p0l1kv6n	435	12	picornavirus	picornavirus	NNP
cord-022290-p0l1kv6n	435	13	super	super	NNP
cord-022290-p0l1kv6n	435	14	-	-	NNP
cord-022290-p0l1kv6n	435	15	group	group	NNP
cord-022290-p0l1kv6n	436	1	On	on	IN
cord-022290-p0l1kv6n	436	2	the	the	DT
cord-022290-p0l1kv6n	436	3	size	size	NN
cord-022290-p0l1kv6n	436	4	of	of	IN
cord-022290-p0l1kv6n	436	5	the	the	DT
cord-022290-p0l1kv6n	436	6	active	active	JJ
cord-022290-p0l1kv6n	436	7	site	site	NN
cord-022290-p0l1kv6n	436	8	in	in	IN
cord-022290-p0l1kv6n	436	9	proteases	protease	NNS
cord-022290-p0l1kv6n	436	10	Proteinase	Proteinase	NNP
cord-022290-p0l1kv6n	436	11	3C	3c	NN
cord-022290-p0l1kv6n	436	12	of	of	IN
cord-022290-p0l1kv6n	436	13	hepatitis	hepatitis	NNP
cord-022290-p0l1kv6n	436	14	A	A	NNP
cord-022290-p0l1kv6n	436	15	virus	virus	NN
cord-022290-p0l1kv6n	436	16	(	(	-LRB-
cord-022290-p0l1kv6n	436	17	HAV	HAV	NNP
cord-022290-p0l1kv6n	436	18	)	)	-RRB-
cord-022290-p0l1kv6n	436	19	cleaves	cleave	VBZ
cord-022290-p0l1kv6n	436	20	the	the	DT
cord-022290-p0l1kv6n	436	21	HAV	HAV	NNP
cord-022290-p0l1kv6n	436	22	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	437	1	P2-P3	p2-p3	NN
cord-022290-p0l1kv6n	437	2	at	at	IN
cord-022290-p0l1kv6n	437	3	all	all	DT
cord-022290-p0l1kv6n	437	4	sites	site	NNS
cord-022290-p0l1kv6n	437	5	including	include	VBG
cord-022290-p0l1kv6n	437	6	VP1/2A	vp1/2a	NN
cord-022290-p0l1kv6n	437	7	and	and	CC
cord-022290-p0l1kv6n	437	8	2A/2B	2a/2b	CD
cord-022290-p0l1kv6n	437	9	Polyprotein	Polyprotein	NNP
cord-022290-p0l1kv6n	437	10	processing	processing	NN
cord-022290-p0l1kv6n	437	11	in	in	IN
cord-022290-p0l1kv6n	437	12	echovirus	echovirus	NNP
cord-022290-p0l1kv6n	437	13	22	22	CD
cord-022290-p0l1kv6n	437	14	-	-	HYPH
cord-022290-p0l1kv6n	437	15	-A	-A	.
cord-022290-p0l1kv6n	438	1	first	first	JJ
cord-022290-p0l1kv6n	438	2	assessment	assessment	NN
cord-022290-p0l1kv6n	438	3	Cleavage	cleavage	NN
cord-022290-p0l1kv6n	438	4	specificity	specificity	NN
cord-022290-p0l1kv6n	438	5	of	of	IN
cord-022290-p0l1kv6n	438	6	purified	purify	VBN
cord-022290-p0l1kv6n	438	7	recombinant	recombinant	JJ
cord-022290-p0l1kv6n	438	8	hepatitis	hepatitis	NN
cord-022290-p0l1kv6n	438	9	A	A	NNP
cord-022290-p0l1kv6n	438	10	virus	virus	NN
cord-022290-p0l1kv6n	438	11	3C	3c	NN
cord-022290-p0l1kv6n	438	12	proteinase	proteinase	NN
cord-022290-p0l1kv6n	438	13	on	on	IN
cord-022290-p0l1kv6n	438	14	natural	natural	JJ
cord-022290-p0l1kv6n	438	15	substrates	substrate	NNS
cord-022290-p0l1kv6n	439	1	A	a	DT
cord-022290-p0l1kv6n	439	2	structural	structural	JJ
cord-022290-p0l1kv6n	439	3	model	model	NN
cord-022290-p0l1kv6n	439	4	of	of	IN
cord-022290-p0l1kv6n	439	5	picornavirus	picornavirus	NNP
cord-022290-p0l1kv6n	439	6	leader	leader	NN
cord-022290-p0l1kv6n	439	7	proteinase	proteinase	NN
cord-022290-p0l1kv6n	439	8	based	base	VBN
cord-022290-p0l1kv6n	439	9	on	on	IN
cord-022290-p0l1kv6n	439	10	papain	papain	NN
cord-022290-p0l1kv6n	439	11	and	and	CC
cord-022290-p0l1kv6n	439	12	bleomycin	bleomycin	NN
cord-022290-p0l1kv6n	439	13	hydrolase	hydrolase	NNP
cord-022290-p0l1kv6n	439	14	Spiro	Spiro	NNP
cord-022290-p0l1kv6n	439	15	indolinone/3	indolinone/3	NN
cord-022290-p0l1kv6n	439	16	-	-	HYPH
cord-022290-p0l1kv6n	439	17	1actams	1actams	CD
cord-022290-p0l1kv6n	439	18	,	,	,
cord-022290-p0l1kv6n	439	19	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	439	20	of	of	IN
cord-022290-p0l1kv6n	439	21	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	439	22	and	and	CC
cord-022290-p0l1kv6n	439	23	rhinovirus	rhinovirus	NNP
cord-022290-p0l1kv6n	439	24	3C	3C	NNP
cord-022290-p0l1kv6n	439	25	-	-	HYPH
cord-022290-p0l1kv6n	439	26	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	439	27	Polypeptide	Polypeptide	NNP
cord-022290-p0l1kv6n	439	28	2A	2a	CD
cord-022290-p0l1kv6n	439	29	of	of	IN
cord-022290-p0l1kv6n	439	30	human	human	JJ
cord-022290-p0l1kv6n	439	31	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	439	32	type	type	NN
cord-022290-p0l1kv6n	439	33	2	2	CD
cord-022290-p0l1kv6n	440	1	:	:	:
cord-022290-p0l1kv6n	440	2	Identification	identification	NN
cord-022290-p0l1kv6n	440	3	as	as	IN
cord-022290-p0l1kv6n	440	4	a	a	DT
cord-022290-p0l1kv6n	440	5	proteinase	proteinase	NN
cord-022290-p0l1kv6n	440	6	and	and	CC
cord-022290-p0l1kv6n	440	7	characterization	characterization	NN
cord-022290-p0l1kv6n	440	8	by	by	IN
cord-022290-p0l1kv6n	440	9	mutational	mutational	JJ
cord-022290-p0l1kv6n	440	10	analysis	analysis	NN
cord-022290-p0l1kv6n	440	11	2A	2A	NNP
cord-022290-p0l1kv6n	440	12	proteinases	proteinases	NNP
cord-022290-p0l1kv6n	440	13	of	of	IN
cord-022290-p0l1kv6n	440	14	coxsackie	coxsackie	NNP
cord-022290-p0l1kv6n	440	15	-	-	:
cord-022290-p0l1kv6n	440	16	and	and	CC
cord-022290-p0l1kv6n	440	17	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	440	18	cleave	cleave	NN
cord-022290-p0l1kv6n	440	19	peptides	peptide	NNS
cord-022290-p0l1kv6n	440	20	derived	derive	VBN
cord-022290-p0l1kv6n	440	21	from	from	IN
cord-022290-p0l1kv6n	440	22	eIF-4y	eIF-4y	NNP
cord-022290-p0l1kv6n	440	23	via	via	IN
cord-022290-p0l1kv6n	440	24	a	a	DT
cord-022290-p0l1kv6n	440	25	common	common	JJ
cord-022290-p0l1kv6n	440	26	recognition	recognition	NN
cord-022290-p0l1kv6n	440	27	motif	motif	NN
cord-022290-p0l1kv6n	441	1	The	the	DT
cord-022290-p0l1kv6n	441	2	2A	2a	CD
cord-022290-p0l1kv6n	441	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	441	4	of	of	IN
cord-022290-p0l1kv6n	441	5	human	human	JJ
cord-022290-p0l1kv6n	441	6	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	441	7	is	be	VBZ
cord-022290-p0l1kv6n	442	1	a	a	DT
cord-022290-p0l1kv6n	442	2	zinc	zinc	NN
cord-022290-p0l1kv6n	442	3	containing	contain	VBG
cord-022290-p0l1kv6n	442	4	enzyme	enzyme	NN
cord-022290-p0l1kv6n	442	5	Mutational	Mutational	NNP
cord-022290-p0l1kv6n	442	6	analyses	analysis	NNS
cord-022290-p0l1kv6n	442	7	support	support	VBP
cord-022290-p0l1kv6n	442	8	a	a	DT
cord-022290-p0l1kv6n	442	9	model	model	NN
cord-022290-p0l1kv6n	442	10	for	for	IN
cord-022290-p0l1kv6n	442	11	the	the	DT
cord-022290-p0l1kv6n	442	12	HRV2	HRV2	NNP
cord-022290-p0l1kv6n	442	13	2A	2a	NN
cord-022290-p0l1kv6n	442	14	proteinase	proteinase	NN
cord-022290-p0l1kv6n	442	15	Viral	viral	JJ
cord-022290-p0l1kv6n	442	16	damage	damage	NN
cord-022290-p0l1kv6n	442	17	and	and	CC
cord-022290-p0l1kv6n	442	18	the	the	DT
cord-022290-p0l1kv6n	442	19	breakdown	breakdown	NN
cord-022290-p0l1kv6n	442	20	of	of	IN
cord-022290-p0l1kv6n	442	21	self	self	NN
cord-022290-p0l1kv6n	442	22	-	-	HYPH
cord-022290-p0l1kv6n	442	23	tolerance	tolerance	NN
cord-022290-p0l1kv6n	442	24	Catalytic	catalytic	JJ
cord-022290-p0l1kv6n	442	25	mechanism	mechanism	NN
cord-022290-p0l1kv6n	442	26	in	in	IN
cord-022290-p0l1kv6n	442	27	papain	papain	NN
cord-022290-p0l1kv6n	442	28	family	family	NN
cord-022290-p0l1kv6n	442	29	of	of	IN
cord-022290-p0l1kv6n	442	30	cysteine	cysteine	NN
cord-022290-p0l1kv6n	442	31	peptidases	peptidase	NNS
cord-022290-p0l1kv6n	443	1	A	a	DT
cord-022290-p0l1kv6n	443	2	second	second	JJ
cord-022290-p0l1kv6n	443	3	proteinase	proteinase	NN
cord-022290-p0l1kv6n	443	4	of	of	IN
cord-022290-p0l1kv6n	443	5	foot	foot	NN
cord-022290-p0l1kv6n	443	6	-	-	HYPH
cord-022290-p0l1kv6n	443	7	and	and	CC
cord-022290-p0l1kv6n	443	8	-	-	HYPH
cord-022290-p0l1kv6n	443	9	mouth	mouth	NN
cord-022290-p0l1kv6n	443	10	disease	disease	NN
cord-022290-p0l1kv6n	443	11	virus	virus	NN
cord-022290-p0l1kv6n	443	12	Induction	induction	NN
cord-022290-p0l1kv6n	443	13	of	of	IN
cord-022290-p0l1kv6n	443	14	intracellular	intracellular	JJ
cord-022290-p0l1kv6n	443	15	membrane	membrane	NN
cord-022290-p0l1kv6n	443	16	rearrangements	rearrangement	NNS
cord-022290-p0l1kv6n	443	17	by	by	IN
cord-022290-p0l1kv6n	443	18	HAV	HAV	NNP
cord-022290-p0l1kv6n	443	19	proteins	protein	NNS
cord-022290-p0l1kv6n	443	20	2C	2c	NN
cord-022290-p0l1kv6n	443	21	and	and	CC
cord-022290-p0l1kv6n	443	22	2BC	2BC	NNP
cord-022290-p0l1kv6n	444	1	Poliovirus	Poliovirus	NNP
cord-022290-p0l1kv6n	444	2	2C	2c	NN
cord-022290-p0l1kv6n	444	3	protein	protein	NN
cord-022290-p0l1kv6n	444	4	determinants	determinant	NNS
cord-022290-p0l1kv6n	444	5	of	of	IN
cord-022290-p0l1kv6n	444	6	membrane	membrane	NN
cord-022290-p0l1kv6n	444	7	binding	binding	NN
cord-022290-p0l1kv6n	444	8	and	and	CC
cord-022290-p0l1kv6n	444	9	rearrangements	rearrangement	NNS
cord-022290-p0l1kv6n	444	10	in	in	IN
cord-022290-p0l1kv6n	444	11	mammalian	mammalian	JJ
cord-022290-p0l1kv6n	444	12	cells	cell	NNS
cord-022290-p0l1kv6n	444	13	Characterization	characterization	NN
cord-022290-p0l1kv6n	444	14	in	in	IN
cord-022290-p0l1kv6n	444	15	vitro	vitro	FW
cord-022290-p0l1kv6n	444	16	of	of	IN
cord-022290-p0l1kv6n	444	17	an	an	DT
cord-022290-p0l1kv6n	444	18	autocatalytic	autocatalytic	JJ
cord-022290-p0l1kv6n	444	19	processing	processing	NN
cord-022290-p0l1kv6n	444	20	activity	activity	NN
cord-022290-p0l1kv6n	444	21	associated	associate	VBN
cord-022290-p0l1kv6n	444	22	with	with	IN
cord-022290-p0l1kv6n	444	23	the	the	DT
cord-022290-p0l1kv6n	444	24	predicted	predict	VBN
cord-022290-p0l1kv6n	444	25	3C	3c	NN
cord-022290-p0l1kv6n	444	26	-	-	HYPH
cord-022290-p0l1kv6n	444	27	like	like	JJ
cord-022290-p0l1kv6n	444	28	proteinase	proteinase	NN
cord-022290-p0l1kv6n	444	29	domain	domain	NN
cord-022290-p0l1kv6n	444	30	of	of	IN
cord-022290-p0l1kv6n	444	31	the	the	DT
cord-022290-p0l1kv6n	444	32	Coronavirus	Coronavirus	NNP
cord-022290-p0l1kv6n	444	33	avian	avian	JJ
cord-022290-p0l1kv6n	444	34	infectious	infectious	JJ
cord-022290-p0l1kv6n	444	35	bronchitis	bronchitis	NN
cord-022290-p0l1kv6n	444	36	virus	virus	NN
cord-022290-p0l1kv6n	444	37	Spectroscopic	spectroscopic	JJ
cord-022290-p0l1kv6n	444	38	characterization	characterization	NN
cord-022290-p0l1kv6n	444	39	of	of	IN
cord-022290-p0l1kv6n	444	40	rhinoviral	rhinoviral	JJ
cord-022290-p0l1kv6n	444	41	protease	protease	NN
cord-022290-p0l1kv6n	444	42	2A	2a	CD
cord-022290-p0l1kv6n	444	43	:	:	:
cord-022290-p0l1kv6n	445	1	Zn	Zn	NNP
cord-022290-p0l1kv6n	445	2	is	be	VBZ
cord-022290-p0l1kv6n	445	3	essential	essential	JJ
cord-022290-p0l1kv6n	445	4	for	for	IN
cord-022290-p0l1kv6n	445	5	structural	structural	JJ
cord-022290-p0l1kv6n	445	6	integrity	integrity	NN
cord-022290-p0l1kv6n	445	7	Sequence	sequence	NN
cord-022290-p0l1kv6n	445	8	and	and	CC
cord-022290-p0l1kv6n	445	9	structural	structural	JJ
cord-022290-p0l1kv6n	445	10	determinants	determinant	NNS
cord-022290-p0l1kv6n	445	11	of	of	IN
cord-022290-p0l1kv6n	445	12	the	the	DT
cord-022290-p0l1kv6n	445	13	interaction	interaction	NN
cord-022290-p0l1kv6n	445	14	between	between	IN
cord-022290-p0l1kv6n	445	15	the	the	DT
cord-022290-p0l1kv6n	445	16	5'-noncoding	5'-noncoding	NNP
cord-022290-p0l1kv6n	445	17	region	region	NN
cord-022290-p0l1kv6n	445	18	of	of	IN
cord-022290-p0l1kv6n	445	19	picornavirus	picornavirus	NNP
cord-022290-p0l1kv6n	445	20	RNA	RNA	NNP
cord-022290-p0l1kv6n	445	21	and	and	CC
cord-022290-p0l1kv6n	445	22	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	445	23	protease	protease	NN
cord-022290-p0l1kv6n	445	24	3C	3C	NNP
cord-022290-p0l1kv6n	445	25	Design	Design	NNP
cord-022290-p0l1kv6n	445	26	synthesis	synthesis	NN
cord-022290-p0l1kv6n	445	27	and	and	CC
cord-022290-p0l1kv6n	445	28	evaluation	evaluation	NN
cord-022290-p0l1kv6n	445	29	of	of	IN
cord-022290-p0l1kv6n	445	30	nonpeptide	nonpeptide	JJ
cord-022290-p0l1kv6n	445	31	inhibitors	inhibitor	NNS
cord-022290-p0l1kv6n	445	32	of	of	IN
cord-022290-p0l1kv6n	445	33	human	human	JJ
cord-022290-p0l1kv6n	445	34	rhinovirus	rhinovirus	NN
cord-022290-p0l1kv6n	445	35	3C	3C	NNP
cord-022290-p0l1kv6n	445	36	proteinase	proteinase	NN
cord-022290-p0l1kv6n	445	37	Development	Development	NNP
cord-022290-p0l1kv6n	445	38	of	of	IN
cord-022290-p0l1kv6n	445	39	synthetic	synthetic	JJ
cord-022290-p0l1kv6n	445	40	peptide	peptide	NN
cord-022290-p0l1kv6n	445	41	substrates	substrate	NNS
cord-022290-p0l1kv6n	445	42	for	for	IN
cord-022290-p0l1kv6n	445	43	the	the	DT
cord-022290-p0l1kv6n	445	44	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	445	45	3C	3c	NN
cord-022290-p0l1kv6n	445	46	proteinase	proteinase	NN
cord-022290-p0l1kv6n	445	47	Details	Details	NNP
cord-022290-p0l1kv6n	445	48	of	of	IN
cord-022290-p0l1kv6n	445	49	the	the	DT
cord-022290-p0l1kv6n	445	50	acyl	acyl	NN
cord-022290-p0l1kv6n	445	51	-	-	HYPH
cord-022290-p0l1kv6n	445	52	enzyme	enzyme	NN
cord-022290-p0l1kv6n	445	53	intermediate	intermediate	NN
cord-022290-p0l1kv6n	445	54	and	and	CC
cord-022290-p0l1kv6n	445	55	the	the	DT
cord-022290-p0l1kv6n	445	56	oxyanion	oxyanion	NN
cord-022290-p0l1kv6n	445	57	hole	hole	NN
cord-022290-p0l1kv6n	445	58	in	in	IN
cord-022290-p0l1kv6n	445	59	serine	serine	JJ
cord-022290-p0l1kv6n	445	60	protease	protease	NN
cord-022290-p0l1kv6n	445	61	catalysis	catalysis	NN
cord-022290-p0l1kv6n	445	62	Genome	Genome	NNP
cord-022290-p0l1kv6n	445	63	linked	link	VBD
cord-022290-p0l1kv6n	445	64	proteins	protein	NNS
cord-022290-p0l1kv6n	445	65	of	of	IN
cord-022290-p0l1kv6n	445	66	viruses	virus	NNS
cord-022290-p0l1kv6n	445	67	Genetics	genetic	NNS
cord-022290-p0l1kv6n	445	68	of	of	IN
cord-022290-p0l1kv6n	445	69	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	446	1	3C	3c	NN
cord-022290-p0l1kv6n	446	2	-	-	HYPH
cord-022290-p0l1kv6n	446	3	like	like	JJ
cord-022290-p0l1kv6n	446	4	protease	protease	NN
cord-022290-p0l1kv6n	446	5	of	of	IN
cord-022290-p0l1kv6n	446	6	rabbit	rabbit	NN
cord-022290-p0l1kv6n	446	7	hemorrhagic	hemorrhagic	JJ
cord-022290-p0l1kv6n	446	8	disease	disease	NN
cord-022290-p0l1kv6n	446	9	virus	virus	NN
cord-022290-p0l1kv6n	446	10	:	:	:
cord-022290-p0l1kv6n	446	11	identification	identification	NN
cord-022290-p0l1kv6n	446	12	of	of	IN
cord-022290-p0l1kv6n	446	13	cleavage	cleavage	NN
cord-022290-p0l1kv6n	446	14	sites	site	NNS
cord-022290-p0l1kv6n	446	15	in	in	IN
cord-022290-p0l1kv6n	446	16	the	the	DT
cord-022290-p0l1kv6n	446	17	ORF1	ORF1	NNP
cord-022290-p0l1kv6n	446	18	polyprotein	polyprotein	NN
cord-022290-p0l1kv6n	446	19	and	and	CC
cord-022290-p0l1kv6n	446	20	analysis	analysis	NN
cord-022290-p0l1kv6n	446	21	of	of	IN
cord-022290-p0l1kv6n	446	22	cleavage	cleavage	NN
cord-022290-p0l1kv6n	446	23	specificity	specificity	NN
cord-022290-p0l1kv6n	446	24	Interaction	interaction	NN
cord-022290-p0l1kv6n	446	25	between	between	IN
cord-022290-p0l1kv6n	446	26	the	the	DT
cord-022290-p0l1kv6n	446	27	5'-terminal	5'-terminal	CD
cord-022290-p0l1kv6n	446	28	cloverleaf	cloverleaf	NN
cord-022290-p0l1kv6n	446	29	and	and	CC
cord-022290-p0l1kv6n	446	30	3AB/3CD	3AB/3CD	.
cord-022290-p0l1kv6n	446	31	Pr~	Pr~	NNP
cord-022290-p0l1kv6n	446	32	of	of	IN
cord-022290-p0l1kv6n	446	33	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	446	34	is	be	VBZ
cord-022290-p0l1kv6n	446	35	essential	essential	JJ
cord-022290-p0l1kv6n	446	36	for	for	IN
cord-022290-p0l1kv6n	446	37	RNA	RNA	NNP
cord-022290-p0l1kv6n	446	38	application	application	NN
cord-022290-p0l1kv6n	446	39	Cleavage	cleavage	NN
cord-022290-p0l1kv6n	446	40	of	of	IN
cord-022290-p0l1kv6n	446	41	transcriptional	transcriptional	JJ
cord-022290-p0l1kv6n	446	42	activator	activator	NN
cord-022290-p0l1kv6n	447	1	Oct-1	Oct-1	NNP
cord-022290-p0l1kv6n	447	2	by	by	IN
cord-022290-p0l1kv6n	447	3	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	447	4	encoded	encode	VBN
cord-022290-p0l1kv6n	447	5	protease	protease	NN
cord-022290-p0l1kv6n	447	6	3C	3C	NNP
cord-022290-p0l1kv6n	447	7	pro	pro	NNP
cord-022290-p0l1kv6n	447	8	Protein	Protein	NNP
cord-022290-p0l1kv6n	447	9	3CD	3CD	NNP
cord-022290-p0l1kv6n	447	10	is	be	VBZ
cord-022290-p0l1kv6n	447	11	the	the	DT
cord-022290-p0l1kv6n	447	12	major	major	JJ
cord-022290-p0l1kv6n	447	13	poliovirus	poliovirus	NN
cord-022290-p0l1kv6n	447	14	proteinase	proteinase	NN
cord-022290-p0l1kv6n	447	15	responsible	responsible	JJ
cord-022290-p0l1kv6n	447	16	for	for	IN
cord-022290-p0l1kv6n	447	17	cleavage	cleavage	NN
cord-022290-p0l1kv6n	447	18	of	of	IN
cord-022290-p0l1kv6n	447	19	the	the	DT
cord-022290-p0l1kv6n	447	20	P1	P1	NNP
cord-022290-p0l1kv6n	447	21	capsid	capsid	NN
cord-022290-p0l1kv6n	447	22	precursor	precursor	NN