id sid tid token lemma pos cord-007714-n3omlvfl 1 1 key key JJ cord-007714-n3omlvfl 1 2 : : : cord-007714-n3omlvfl 1 3 cord-007714-n3omlvfl cord-007714-n3omlvfl NN cord-007714-n3omlvfl 1 4 authors author NNS cord-007714-n3omlvfl 1 5 : : : cord-007714-n3omlvfl 1 6 Brown Brown NNP cord-007714-n3omlvfl 1 7 , , , cord-007714-n3omlvfl 1 8 J. J. NNP cord-007714-n3omlvfl 1 9 W. W. NNP cord-007714-n3omlvfl 1 10 S. S. NNP cord-007714-n3omlvfl 1 11 ; ; : cord-007714-n3omlvfl 1 12 Shaw Shaw NNP cord-007714-n3omlvfl 1 13 , , , cord-007714-n3omlvfl 1 14 P. P. NNP cord-007714-n3omlvfl 1 15 J. J. NNP cord-007714-n3omlvfl 2 1 title title NN cord-007714-n3omlvfl 2 2 : : : cord-007714-n3omlvfl 3 1 The the DT cord-007714-n3omlvfl 3 2 Role role NN cord-007714-n3omlvfl 3 3 of of IN cord-007714-n3omlvfl 3 4 the the DT cord-007714-n3omlvfl 3 5 Plant Plant NNP cord-007714-n3omlvfl 3 6 Nucleolus Nucleolus NNP cord-007714-n3omlvfl 3 7 in in IN cord-007714-n3omlvfl 3 8 Pre Pre NNP cord-007714-n3omlvfl 3 9 - - JJ cord-007714-n3omlvfl 3 10 mRNA mRNA NNP cord-007714-n3omlvfl 3 11 Processing processing NN cord-007714-n3omlvfl 3 12 date date NN cord-007714-n3omlvfl 3 13 : : : cord-007714-n3omlvfl 3 14 2008 2008 CD cord-007714-n3omlvfl 3 15 journal journal NN cord-007714-n3omlvfl 3 16 : : : cord-007714-n3omlvfl 4 1 Nuclear nuclear JJ cord-007714-n3omlvfl 4 2 pre pre NN cord-007714-n3omlvfl 4 3 - - NN cord-007714-n3omlvfl 4 4 mRNA mrna NN cord-007714-n3omlvfl 5 1 Processing process VBG cord-007714-n3omlvfl 5 2 in in IN cord-007714-n3omlvfl 5 3 Plants plant NNS cord-007714-n3omlvfl 6 1 DOI DOI NNP cord-007714-n3omlvfl 7 1 : : : cord-007714-n3omlvfl 7 2 10.1007/978 10.1007/978 LS cord-007714-n3omlvfl 7 3 - - SYM cord-007714-n3omlvfl 7 4 3 3 CD cord-007714-n3omlvfl 7 5 - - HYPH cord-007714-n3omlvfl 7 6 540 540 CD cord-007714-n3omlvfl 7 7 - - HYPH cord-007714-n3omlvfl 7 8 76776 76776 CD cord-007714-n3omlvfl 7 9 - - HYPH cord-007714-n3omlvfl 7 10 3_16 3_16 CD cord-007714-n3omlvfl 7 11 sha sha NNP cord-007714-n3omlvfl 7 12 : : : cord-007714-n3omlvfl 8 1 17100126cac93cd82c74d4f590fc16867f124d5e 17100126cac93cd82c74d4f590fc16867f124d5e NNP cord-007714-n3omlvfl 8 2 doc_id doc_id CD cord-007714-n3omlvfl 8 3 : : : cord-007714-n3omlvfl 9 1 7714 7714 CD cord-007714-n3omlvfl 9 2 cord_uid cord_uid NNS cord-007714-n3omlvfl 9 3 : : : cord-007714-n3omlvfl 10 1 n3omlvfl n3omlvfl NNP cord-007714-n3omlvfl 10 2 The the DT cord-007714-n3omlvfl 10 3 nucleolus nucleolus NN cord-007714-n3omlvfl 10 4 is be VBZ cord-007714-n3omlvfl 10 5 a a DT cord-007714-n3omlvfl 10 6 multifunctional multifunctional JJ cord-007714-n3omlvfl 10 7 compartment compartment NN cord-007714-n3omlvfl 10 8 of of IN cord-007714-n3omlvfl 10 9 the the DT cord-007714-n3omlvfl 10 10 eukaryotic eukaryotic JJ cord-007714-n3omlvfl 10 11 nucleus nucleus NN cord-007714-n3omlvfl 10 12 . . . cord-007714-n3omlvfl 11 1 Besides besides IN cord-007714-n3omlvfl 11 2 its -PRON- PRP$ cord-007714-n3omlvfl 11 3 well well RB cord-007714-n3omlvfl 11 4 - - HYPH cord-007714-n3omlvfl 11 5 recognised recognise VBN cord-007714-n3omlvfl 11 6 role role NN cord-007714-n3omlvfl 11 7 in in IN cord-007714-n3omlvfl 11 8 transcription transcription NN cord-007714-n3omlvfl 11 9 and and CC cord-007714-n3omlvfl 11 10 processing processing NN cord-007714-n3omlvfl 11 11 of of IN cord-007714-n3omlvfl 11 12 ribosomal ribosomal JJ cord-007714-n3omlvfl 11 13 RNA RNA NNP cord-007714-n3omlvfl 11 14 and and CC cord-007714-n3omlvfl 11 15 the the DT cord-007714-n3omlvfl 11 16 assembly assembly NN cord-007714-n3omlvfl 11 17 of of IN cord-007714-n3omlvfl 11 18 ribosomal ribosomal JJ cord-007714-n3omlvfl 11 19 subunits subunit NNS cord-007714-n3omlvfl 11 20 , , , cord-007714-n3omlvfl 11 21 the the DT cord-007714-n3omlvfl 11 22 nucleolus nucleolus NN cord-007714-n3omlvfl 11 23 has have VBZ cord-007714-n3omlvfl 11 24 functions function NNS cord-007714-n3omlvfl 11 25 in in IN cord-007714-n3omlvfl 11 26 the the DT cord-007714-n3omlvfl 11 27 processing processing NN cord-007714-n3omlvfl 11 28 and and CC cord-007714-n3omlvfl 11 29 assembly assembly NN cord-007714-n3omlvfl 11 30 of of IN cord-007714-n3omlvfl 11 31 a a DT cord-007714-n3omlvfl 11 32 variety variety NN cord-007714-n3omlvfl 11 33 of of IN cord-007714-n3omlvfl 11 34 RNPs rnp NNS cord-007714-n3omlvfl 11 35 and and CC cord-007714-n3omlvfl 11 36 is be VBZ cord-007714-n3omlvfl 11 37 involved involve VBN cord-007714-n3omlvfl 11 38 in in IN cord-007714-n3omlvfl 11 39 cell cell NN cord-007714-n3omlvfl 11 40 cycle cycle NN cord-007714-n3omlvfl 11 41 control control NN cord-007714-n3omlvfl 11 42 and and CC cord-007714-n3omlvfl 11 43 senescence senescence NN cord-007714-n3omlvfl 11 44 and and CC cord-007714-n3omlvfl 11 45 as as IN cord-007714-n3omlvfl 11 46 a a DT cord-007714-n3omlvfl 11 47 sensor sensor NN cord-007714-n3omlvfl 11 48 of of IN cord-007714-n3omlvfl 11 49 stress stress NN cord-007714-n3omlvfl 11 50 . . . cord-007714-n3omlvfl 12 1 Historically historically RB cord-007714-n3omlvfl 12 2 , , , cord-007714-n3omlvfl 12 3 nucleoli nucleoli NNP cord-007714-n3omlvfl 12 4 have have VBP cord-007714-n3omlvfl 12 5 been be VBN cord-007714-n3omlvfl 12 6 tenuously tenuously RB cord-007714-n3omlvfl 12 7 linked link VBN cord-007714-n3omlvfl 12 8 to to IN cord-007714-n3omlvfl 12 9 the the DT cord-007714-n3omlvfl 12 10 biogenesis biogenesis NN cord-007714-n3omlvfl 12 11 and and CC cord-007714-n3omlvfl 12 12 , , , cord-007714-n3omlvfl 12 13 in in IN cord-007714-n3omlvfl 12 14 particular particular JJ cord-007714-n3omlvfl 12 15 , , , cord-007714-n3omlvfl 12 16 export export NN cord-007714-n3omlvfl 12 17 of of IN cord-007714-n3omlvfl 12 18 mRNAs mRNAs NNPS cord-007714-n3omlvfl 12 19 in in IN cord-007714-n3omlvfl 12 20 yeast yeast NN cord-007714-n3omlvfl 12 21 and and CC cord-007714-n3omlvfl 12 22 mammalian mammalian JJ cord-007714-n3omlvfl 12 23 cells cell NNS cord-007714-n3omlvfl 12 24 . . . cord-007714-n3omlvfl 13 1 Recently recently RB cord-007714-n3omlvfl 13 2 , , , cord-007714-n3omlvfl 13 3 data datum NNS cord-007714-n3omlvfl 13 4 from from IN cord-007714-n3omlvfl 13 5 plants plant NNS cord-007714-n3omlvfl 13 6 have have VBP cord-007714-n3omlvfl 13 7 extended extend VBN cord-007714-n3omlvfl 13 8 the the DT cord-007714-n3omlvfl 13 9 functions function NNS cord-007714-n3omlvfl 13 10 in in IN cord-007714-n3omlvfl 13 11 which which WDT cord-007714-n3omlvfl 13 12 the the DT cord-007714-n3omlvfl 13 13 plant plant NN cord-007714-n3omlvfl 13 14 nucleolus nucleolus NN cord-007714-n3omlvfl 13 15 is be VBZ cord-007714-n3omlvfl 13 16 involved involve VBN cord-007714-n3omlvfl 13 17 to to TO cord-007714-n3omlvfl 13 18 include include VB cord-007714-n3omlvfl 13 19 transcriptional transcriptional JJ cord-007714-n3omlvfl 13 20 gene gene NN cord-007714-n3omlvfl 13 21 silencing silencing NN cord-007714-n3omlvfl 13 22 as as RB cord-007714-n3omlvfl 13 23 well well RB cord-007714-n3omlvfl 13 24 as as IN cord-007714-n3omlvfl 13 25 mRNA mrna NN cord-007714-n3omlvfl 13 26 surveillance surveillance NN cord-007714-n3omlvfl 13 27 and and CC cord-007714-n3omlvfl 13 28 nonsense nonsense NN cord-007714-n3omlvfl 13 29 - - HYPH cord-007714-n3omlvfl 13 30 mediated mediate VBN cord-007714-n3omlvfl 13 31 decay decay NN cord-007714-n3omlvfl 13 32 , , , cord-007714-n3omlvfl 13 33 and and CC cord-007714-n3omlvfl 13 34 mRNA mrna NN cord-007714-n3omlvfl 13 35 export export NN cord-007714-n3omlvfl 13 36 . . . cord-007714-n3omlvfl 14 1 The the DT cord-007714-n3omlvfl 14 2 nucleolus nucleolus NN cord-007714-n3omlvfl 14 3 in in IN cord-007714-n3omlvfl 14 4 plants plant NNS cord-007714-n3omlvfl 14 5 may may MD cord-007714-n3omlvfl 14 6 therefore therefore RB cord-007714-n3omlvfl 14 7 have have VB cord-007714-n3omlvfl 14 8 important important JJ cord-007714-n3omlvfl 14 9 roles role NNS cord-007714-n3omlvfl 14 10 in in IN cord-007714-n3omlvfl 14 11 the the DT cord-007714-n3omlvfl 14 12 biogenesis biogenesis NN cord-007714-n3omlvfl 14 13 and and CC cord-007714-n3omlvfl 14 14 quality quality NN cord-007714-n3omlvfl 14 15 control control NN cord-007714-n3omlvfl 14 16 of of IN cord-007714-n3omlvfl 14 17 mRNAs mrnas CD cord-007714-n3omlvfl 14 18 . . . cord-007714-n3omlvfl 15 1 The the DT cord-007714-n3omlvfl 15 2 nucleolus nucleolus NN cord-007714-n3omlvfl 15 3 is be VBZ cord-007714-n3omlvfl 15 4 the the DT cord-007714-n3omlvfl 15 5 largest large JJS cord-007714-n3omlvfl 15 6 and and CC cord-007714-n3omlvfl 15 7 most most RBS cord-007714-n3omlvfl 15 8 visible visible JJ cord-007714-n3omlvfl 15 9 sub sub JJ cord-007714-n3omlvfl 15 10 - - JJ cord-007714-n3omlvfl 15 11 nuclear nuclear JJ cord-007714-n3omlvfl 15 12 compartment compartment NN cord-007714-n3omlvfl 15 13 . . . cord-007714-n3omlvfl 16 1 Its -PRON- PRP$ cord-007714-n3omlvfl 16 2 main main JJ cord-007714-n3omlvfl 16 3 function function NN cord-007714-n3omlvfl 16 4 is be VBZ cord-007714-n3omlvfl 16 5 the the DT cord-007714-n3omlvfl 16 6 transcription transcription NN cord-007714-n3omlvfl 16 7 and and CC cord-007714-n3omlvfl 16 8 processing processing NN cord-007714-n3omlvfl 16 9 of of IN cord-007714-n3omlvfl 16 10 ribosomal ribosomal JJ cord-007714-n3omlvfl 16 11 RNA RNA NNP cord-007714-n3omlvfl 16 12 ( ( -LRB- cord-007714-n3omlvfl 16 13 rRNA rRNA NNP cord-007714-n3omlvfl 16 14 ) ) -RRB- cord-007714-n3omlvfl 16 15 and and CC cord-007714-n3omlvfl 16 16 ribosomal ribosomal JJ cord-007714-n3omlvfl 16 17 subunit subunit NN cord-007714-n3omlvfl 16 18 production production NN cord-007714-n3omlvfl 16 19 . . . cord-007714-n3omlvfl 17 1 In in IN cord-007714-n3omlvfl 17 2 recent recent JJ cord-007714-n3omlvfl 17 3 years year NNS cord-007714-n3omlvfl 17 4 , , , cord-007714-n3omlvfl 17 5 molecular molecular JJ cord-007714-n3omlvfl 17 6 and and CC cord-007714-n3omlvfl 17 7 proteomic proteomic JJ cord-007714-n3omlvfl 17 8 approaches approach NNS cord-007714-n3omlvfl 17 9 have have VBP cord-007714-n3omlvfl 17 10 begun begin VBN cord-007714-n3omlvfl 17 11 to to TO cord-007714-n3omlvfl 17 12 dissect dissect VB cord-007714-n3omlvfl 17 13 the the DT cord-007714-n3omlvfl 17 14 pathways pathway NNS cord-007714-n3omlvfl 17 15 of of IN cord-007714-n3omlvfl 17 16 ribosomal ribosomal JJ cord-007714-n3omlvfl 17 17 subunit subunit NN cord-007714-n3omlvfl 17 18 assembly assembly NN cord-007714-n3omlvfl 17 19 and and CC cord-007714-n3omlvfl 17 20 transport transport NN cord-007714-n3omlvfl 17 21 from from IN cord-007714-n3omlvfl 17 22 the the DT cord-007714-n3omlvfl 17 23 nucleolus nucleolus NN cord-007714-n3omlvfl 17 24 and and CC cord-007714-n3omlvfl 17 25 examine examine VB cord-007714-n3omlvfl 17 26 the the DT cord-007714-n3omlvfl 17 27 composition composition NN cord-007714-n3omlvfl 17 28 of of IN cord-007714-n3omlvfl 17 29 protein protein NN cord-007714-n3omlvfl 17 30 complexes complex NNS cord-007714-n3omlvfl 17 31 and and CC cord-007714-n3omlvfl 17 32 RNPs rnp NNS cord-007714-n3omlvfl 17 33 involved involve VBN cord-007714-n3omlvfl 17 34 in in IN cord-007714-n3omlvfl 17 35 these these DT cord-007714-n3omlvfl 17 36 processes process NNS cord-007714-n3omlvfl 17 37 ( ( -LRB- cord-007714-n3omlvfl 17 38 Grandi Grandi NNP cord-007714-n3omlvfl 17 39 et et NNP cord-007714-n3omlvfl 17 40 al al NNP cord-007714-n3omlvfl 17 41 . . . cord-007714-n3omlvfl 17 42 2002 2002 CD cord-007714-n3omlvfl 17 43 ; ; : cord-007714-n3omlvfl 17 44 Dragon Dragon NNP cord-007714-n3omlvfl 17 45 et et NNP cord-007714-n3omlvfl 17 46 al al NNP cord-007714-n3omlvfl 17 47 . . . cord-007714-n3omlvfl 18 1 2002 2002 CD cord-007714-n3omlvfl 18 2 ; ; : cord-007714-n3omlvfl 18 3 Schafer Schafer NNP cord-007714-n3omlvfl 18 4 et et NNP cord-007714-n3omlvfl 18 5 al al NNP cord-007714-n3omlvfl 18 6 . . . cord-007714-n3omlvfl 19 1 2003 2003 CD cord-007714-n3omlvfl 19 2 ; ; : cord-007714-n3omlvfl 19 3 Gallagher Gallagher NNP cord-007714-n3omlvfl 19 4 et et NNP cord-007714-n3omlvfl 19 5 al al NNP cord-007714-n3omlvfl 19 6 . . . cord-007714-n3omlvfl 20 1 2004 2004 CD cord-007714-n3omlvfl 20 2 ; ; : cord-007714-n3omlvfl 20 3 Baserga Baserga NNP cord-007714-n3omlvfl 20 4 2004 2004 CD cord-007714-n3omlvfl 20 5 , , , cord-007714-n3omlvfl 20 6 2005 2005 CD cord-007714-n3omlvfl 20 7 ) ) -RRB- cord-007714-n3omlvfl 20 8 . . . cord-007714-n3omlvfl 21 1 In in IN cord-007714-n3omlvfl 21 2 addition addition NN cord-007714-n3omlvfl 21 3 , , , cord-007714-n3omlvfl 21 4 many many JJ cord-007714-n3omlvfl 21 5 lines line NNS cord-007714-n3omlvfl 21 6 of of IN cord-007714-n3omlvfl 21 7 evidence evidence NN cord-007714-n3omlvfl 21 8 point point NN cord-007714-n3omlvfl 21 9 to to IN cord-007714-n3omlvfl 21 10 the the DT cord-007714-n3omlvfl 21 11 nucleolus nucleolus NN cord-007714-n3omlvfl 21 12 having have VBG cord-007714-n3omlvfl 21 13 a a DT cord-007714-n3omlvfl 21 14 wide wide JJ cord-007714-n3omlvfl 21 15 range range NN cord-007714-n3omlvfl 21 16 of of IN cord-007714-n3omlvfl 21 17 other other JJ cord-007714-n3omlvfl 21 18 functions function NNS cord-007714-n3omlvfl 21 19 in in IN cord-007714-n3omlvfl 21 20 both both DT cord-007714-n3omlvfl 21 21 RNA RNA NNP cord-007714-n3omlvfl 21 22 metabolism metabolism NN cord-007714-n3omlvfl 21 23 and and CC cord-007714-n3omlvfl 21 24 cell cell NN cord-007714-n3omlvfl 21 25 growth growth NN cord-007714-n3omlvfl 21 26 ( ( -LRB- cord-007714-n3omlvfl 21 27 for for IN cord-007714-n3omlvfl 21 28 reviews review NNS cord-007714-n3omlvfl 21 29 see see VBP cord-007714-n3omlvfl 21 30 Pederson Pederson NNP cord-007714-n3omlvfl 21 31 1998 1998 CD cord-007714-n3omlvfl 21 32 ; ; : cord-007714-n3omlvfl 21 33 Olsen Olsen NNP cord-007714-n3omlvfl 21 34 et et NNP cord-007714-n3omlvfl 21 35 al al NNP cord-007714-n3omlvfl 21 36 . . . cord-007714-n3omlvfl 21 37 2000 2000 CD cord-007714-n3omlvfl 21 38 ; ; : cord-007714-n3omlvfl 21 39 Olsen Olsen NNP cord-007714-n3omlvfl 21 40 2004 2004 CD cord-007714-n3omlvfl 21 41 ; ; : cord-007714-n3omlvfl 21 42 Raška Raška NNP cord-007714-n3omlvfl 21 43 et et FW cord-007714-n3omlvfl 21 44 al al NNP cord-007714-n3omlvfl 21 45 . . . cord-007714-n3omlvfl 22 1 2006 2006 CD cord-007714-n3omlvfl 22 2 ; ; : cord-007714-n3omlvfl 22 3 Boisvert Boisvert NNP cord-007714-n3omlvfl 22 4 et et NNP cord-007714-n3omlvfl 22 5 al al NNP cord-007714-n3omlvfl 22 6 . . NNP cord-007714-n3omlvfl 22 7 2007 2007 CD cord-007714-n3omlvfl 22 8 ) ) -RRB- cord-007714-n3omlvfl 22 9 . . . cord-007714-n3omlvfl 23 1 The the DT cord-007714-n3omlvfl 23 2 multifunctional multifunctional JJ cord-007714-n3omlvfl 23 3 nature nature NN cord-007714-n3omlvfl 23 4 of of IN cord-007714-n3omlvfl 23 5 the the DT cord-007714-n3omlvfl 23 6 nucleolus nucleolus NN cord-007714-n3omlvfl 23 7 has have VBZ cord-007714-n3omlvfl 23 8 also also RB cord-007714-n3omlvfl 23 9 been be VBN cord-007714-n3omlvfl 23 10 highlighted highlight VBN cord-007714-n3omlvfl 23 11 by by IN cord-007714-n3omlvfl 23 12 proteomic proteomic JJ cord-007714-n3omlvfl 23 13 approaches approach NNS cord-007714-n3omlvfl 23 14 which which WDT cord-007714-n3omlvfl 23 15 have have VBP cord-007714-n3omlvfl 23 16 identified identify VBN cord-007714-n3omlvfl 23 17 numerous numerous JJ cord-007714-n3omlvfl 23 18 unexpected unexpected JJ cord-007714-n3omlvfl 23 19 proteins protein NNS cord-007714-n3omlvfl 23 20 in in IN cord-007714-n3omlvfl 23 21 the the DT cord-007714-n3omlvfl 23 22 nucleolus nucleolus NN cord-007714-n3omlvfl 23 23 , , , cord-007714-n3omlvfl 23 24 indicative indicative JJ cord-007714-n3omlvfl 23 25 of of IN cord-007714-n3omlvfl 23 26 new new JJ cord-007714-n3omlvfl 23 27 interactions interaction NNS cord-007714-n3omlvfl 23 28 or or CC cord-007714-n3omlvfl 23 29 functions function NNS cord-007714-n3omlvfl 23 30 ( ( -LRB- cord-007714-n3omlvfl 23 31 Andersen Andersen NNP cord-007714-n3omlvfl 23 32 et et NNP cord-007714-n3omlvfl 23 33 al al NNP cord-007714-n3omlvfl 23 34 . . . cord-007714-n3omlvfl 24 1 2002 2002 CD cord-007714-n3omlvfl 25 1 Scherl Scherl NNP cord-007714-n3omlvfl 25 2 et et NNP cord-007714-n3omlvfl 25 3 al al NNP cord-007714-n3omlvfl 25 4 . . . cord-007714-n3omlvfl 26 1 2002 2002 CD cord-007714-n3omlvfl 26 2 ; ; : cord-007714-n3omlvfl 26 3 Pendle Pendle NNP cord-007714-n3omlvfl 26 4 et et NNP cord-007714-n3omlvfl 26 5 al al NNP cord-007714-n3omlvfl 26 6 . . NNP cord-007714-n3omlvfl 26 7 2005 2005 CD cord-007714-n3omlvfl 26 8 ) ) -RRB- cord-007714-n3omlvfl 26 9 . . . cord-007714-n3omlvfl 27 1 The the DT cord-007714-n3omlvfl 27 2 presence presence NN cord-007714-n3omlvfl 27 3 of of IN cord-007714-n3omlvfl 27 4 non non JJ cord-007714-n3omlvfl 27 5 - - JJ cord-007714-n3omlvfl 27 6 ribosomal ribosomal JJ cord-007714-n3omlvfl 27 7 RNAs rna NNS cord-007714-n3omlvfl 27 8 such such JJ cord-007714-n3omlvfl 27 9 as as IN cord-007714-n3omlvfl 27 10 the the DT cord-007714-n3omlvfl 27 11 RNA RNA NNP cord-007714-n3omlvfl 27 12 moieties moiety NNS cord-007714-n3omlvfl 27 13 of of IN cord-007714-n3omlvfl 27 14 the the DT cord-007714-n3omlvfl 27 15 signal signal NN cord-007714-n3omlvfl 27 16 recognition recognition NN cord-007714-n3omlvfl 27 17 particle particle NN cord-007714-n3omlvfl 27 18 ( ( -LRB- cord-007714-n3omlvfl 27 19 SRP SRP NNP cord-007714-n3omlvfl 27 20 ) ) -RRB- cord-007714-n3omlvfl 27 21 and and CC cord-007714-n3omlvfl 27 22 telomerase telomerase NN cord-007714-n3omlvfl 27 23 and and CC cord-007714-n3omlvfl 27 24 some some DT cord-007714-n3omlvfl 27 25 tRNAs trna NNS cord-007714-n3omlvfl 27 26 suggests suggest VBZ cord-007714-n3omlvfl 27 27 roles role NNS cord-007714-n3omlvfl 27 28 in in IN cord-007714-n3omlvfl 27 29 processing processing NN cord-007714-n3omlvfl 27 30 and and CC cord-007714-n3omlvfl 27 31 assembly assembly NN cord-007714-n3omlvfl 27 32 of of IN cord-007714-n3omlvfl 27 33 other other JJ cord-007714-n3omlvfl 27 34 RNAs rna NNS cord-007714-n3omlvfl 27 35 and and CC cord-007714-n3omlvfl 27 36 RNPs rnp NNS cord-007714-n3omlvfl 27 37 ( ( -LRB- cord-007714-n3omlvfl 27 38 Pederson Pederson NNP cord-007714-n3omlvfl 27 39 1998 1998 CD cord-007714-n3omlvfl 27 40 ; ; : cord-007714-n3omlvfl 27 41 Olsen Olsen NNP cord-007714-n3omlvfl 27 42 et et NNP cord-007714-n3omlvfl 27 43 al al NNP cord-007714-n3omlvfl 27 44 . . . cord-007714-n3omlvfl 27 45 2000 2000 CD cord-007714-n3omlvfl 27 46 ; ; : cord-007714-n3omlvfl 27 47 Olsen Olsen NNP cord-007714-n3omlvfl 27 48 2004 2004 CD cord-007714-n3omlvfl 27 49 ; ; : cord-007714-n3omlvfl 27 50 Boisvert Boisvert NNP cord-007714-n3omlvfl 27 51 et et NNP cord-007714-n3omlvfl 27 52 al al NNP cord-007714-n3omlvfl 27 53 . . NNP cord-007714-n3omlvfl 27 54 2007 2007 CD cord-007714-n3omlvfl 27 55 ) ) -RRB- cord-007714-n3omlvfl 27 56 . . . cord-007714-n3omlvfl 28 1 In in IN cord-007714-n3omlvfl 28 2 this this DT cord-007714-n3omlvfl 28 3 aspect aspect NN cord-007714-n3omlvfl 28 4 , , , cord-007714-n3omlvfl 28 5 plants plant NNS cord-007714-n3omlvfl 28 6 are be VBP cord-007714-n3omlvfl 28 7 of of IN cord-007714-n3omlvfl 28 8 growing grow VBG cord-007714-n3omlvfl 28 9 importance importance NN cord-007714-n3omlvfl 28 10 through through IN cord-007714-n3omlvfl 28 11 the the DT cord-007714-n3omlvfl 28 12 recent recent JJ cord-007714-n3omlvfl 28 13 linking linking NN cord-007714-n3omlvfl 28 14 of of IN cord-007714-n3omlvfl 28 15 the the DT cord-007714-n3omlvfl 28 16 nucleolus nucleolus NN cord-007714-n3omlvfl 28 17 to to IN cord-007714-n3omlvfl 28 18 production production NN cord-007714-n3omlvfl 28 19 of of IN cord-007714-n3omlvfl 28 20 heterochromatic heterochromatic JJ cord-007714-n3omlvfl 28 21 siR siR NNP cord-007714-n3omlvfl 28 22 - - HYPH cord-007714-n3omlvfl 28 23 NAs na NNS cord-007714-n3omlvfl 28 24 and and CC cord-007714-n3omlvfl 28 25 transcriptional transcriptional JJ cord-007714-n3omlvfl 28 26 gene gene NN cord-007714-n3omlvfl 28 27 silencing silence VBG cord-007714-n3omlvfl 28 28 Pontes Pontes NNPS cord-007714-n3omlvfl 28 29 et et NNP cord-007714-n3omlvfl 28 30 al al NNP cord-007714-n3omlvfl 28 31 . . . cord-007714-n3omlvfl 28 32 2006 2006 CD cord-007714-n3omlvfl 28 33 ) ) -RRB- cord-007714-n3omlvfl 28 34 and and CC cord-007714-n3omlvfl 28 35 to to IN cord-007714-n3omlvfl 28 36 mRNA mRNA NNP cord-007714-n3omlvfl 28 37 export export NNP cord-007714-n3omlvfl 28 38 , , , cord-007714-n3omlvfl 28 39 mRNA mrna NN cord-007714-n3omlvfl 28 40 surveillance surveillance NN cord-007714-n3omlvfl 28 41 and and CC cord-007714-n3omlvfl 28 42 nonsense nonsense NN cord-007714-n3omlvfl 28 43 - - HYPH cord-007714-n3omlvfl 28 44 mediated mediate VBN cord-007714-n3omlvfl 28 45 decay decay NN cord-007714-n3omlvfl 29 1 ( ( -LRB- cord-007714-n3omlvfl 29 2 Kim Kim NNP cord-007714-n3omlvfl 29 3 et et NNP cord-007714-n3omlvfl 29 4 al al NNP cord-007714-n3omlvfl 29 5 . . . cord-007714-n3omlvfl 30 1 , , , cord-007714-n3omlvfl 30 2 unpublished unpublished JJ cord-007714-n3omlvfl 30 3 ) ) -RRB- cord-007714-n3omlvfl 30 4 . . . cord-007714-n3omlvfl 31 1 Finally finally RB cord-007714-n3omlvfl 31 2 , , , cord-007714-n3omlvfl 31 3 the the DT cord-007714-n3omlvfl 31 4 nucleolus nucleolus NN cord-007714-n3omlvfl 31 5 has have VBZ cord-007714-n3omlvfl 31 6 been be VBN cord-007714-n3omlvfl 31 7 shown show VBN cord-007714-n3omlvfl 31 8 to to TO cord-007714-n3omlvfl 31 9 be be VB cord-007714-n3omlvfl 31 10 crucial crucial JJ cord-007714-n3omlvfl 31 11 to to IN cord-007714-n3omlvfl 31 12 cell cell NN cord-007714-n3omlvfl 31 13 division division NN cord-007714-n3omlvfl 31 14 regulation regulation NN cord-007714-n3omlvfl 31 15 and and CC cord-007714-n3omlvfl 31 16 senescence senescence NN cord-007714-n3omlvfl 31 17 and and CC cord-007714-n3omlvfl 31 18 as as IN cord-007714-n3omlvfl 31 19 a a DT cord-007714-n3omlvfl 31 20 sensor sensor NN cord-007714-n3omlvfl 31 21 of of IN cord-007714-n3omlvfl 31 22 cell cell NN cord-007714-n3omlvfl 31 23 stress stress NN cord-007714-n3omlvfl 31 24 ( ( -LRB- cord-007714-n3omlvfl 31 25 Rubbi Rubbi NNP cord-007714-n3omlvfl 31 26 and and CC cord-007714-n3omlvfl 31 27 Milner Milner NNP cord-007714-n3omlvfl 31 28 2003 2003 CD cord-007714-n3omlvfl 31 29 ; ; : cord-007714-n3omlvfl 31 30 Olsen Olsen NNP cord-007714-n3omlvfl 31 31 2004 2004 CD cord-007714-n3omlvfl 31 32 ; ; : cord-007714-n3omlvfl 31 33 Boisvert Boisvert NNP cord-007714-n3omlvfl 31 34 et et NNP cord-007714-n3omlvfl 31 35 al al NNP cord-007714-n3omlvfl 31 36 . . NNP cord-007714-n3omlvfl 31 37 2007 2007 CD cord-007714-n3omlvfl 31 38 ) ) -RRB- cord-007714-n3omlvfl 31 39 . . . cord-007714-n3omlvfl 32 1 In in IN cord-007714-n3omlvfl 32 2 this this DT cord-007714-n3omlvfl 32 3 chapter chapter NN cord-007714-n3omlvfl 32 4 , , , cord-007714-n3omlvfl 32 5 we -PRON- PRP cord-007714-n3omlvfl 32 6 examine examine VBP cord-007714-n3omlvfl 32 7 the the DT cord-007714-n3omlvfl 32 8 multifunctionality multifunctionality NN cord-007714-n3omlvfl 32 9 of of IN cord-007714-n3omlvfl 32 10 the the DT cord-007714-n3omlvfl 32 11 eukaryotic eukaryotic JJ cord-007714-n3omlvfl 32 12 nucleolus nucleolus NN cord-007714-n3omlvfl 32 13 and and CC cord-007714-n3omlvfl 32 14 describe describe VBP cord-007714-n3omlvfl 32 15 recent recent JJ cord-007714-n3omlvfl 32 16 data datum NNS cord-007714-n3omlvfl 32 17 on on IN cord-007714-n3omlvfl 32 18 novel novel JJ cord-007714-n3omlvfl 32 19 functions function NNS cord-007714-n3omlvfl 32 20 of of IN cord-007714-n3omlvfl 32 21 the the DT cord-007714-n3omlvfl 32 22 plant plant NN cord-007714-n3omlvfl 32 23 nucleolus nucleolus NN cord-007714-n3omlvfl 32 24 and and CC cord-007714-n3omlvfl 32 25 , , , cord-007714-n3omlvfl 32 26 in in IN cord-007714-n3omlvfl 32 27 particular particular JJ cord-007714-n3omlvfl 32 28 , , , cord-007714-n3omlvfl 32 29 its -PRON- PRP$ cord-007714-n3omlvfl 32 30 potential potential JJ cord-007714-n3omlvfl 32 31 roles role NNS cord-007714-n3omlvfl 32 32 in in IN cord-007714-n3omlvfl 32 33 mRNA mrna NN cord-007714-n3omlvfl 32 34 processing processing NN cord-007714-n3omlvfl 32 35 and and CC cord-007714-n3omlvfl 32 36 biogenesis biogenesis NN cord-007714-n3omlvfl 32 37 . . . cord-007714-n3omlvfl 33 1 The the DT cord-007714-n3omlvfl 33 2 nucleus nucleus NN cord-007714-n3omlvfl 33 3 is be VBZ cord-007714-n3omlvfl 33 4 the the DT cord-007714-n3omlvfl 33 5 defining define VBG cord-007714-n3omlvfl 33 6 eukaryotic eukaryotic JJ cord-007714-n3omlvfl 33 7 organelle organelle NN cord-007714-n3omlvfl 33 8 . . . cord-007714-n3omlvfl 34 1 It -PRON- PRP cord-007714-n3omlvfl 34 2 is be VBZ cord-007714-n3omlvfl 34 3 highly highly RB cord-007714-n3omlvfl 34 4 organised organise VBN cord-007714-n3omlvfl 34 5 , , , cord-007714-n3omlvfl 34 6 with with IN cord-007714-n3omlvfl 34 7 chromatin chromatin NN cord-007714-n3omlvfl 34 8 regions region NNS cord-007714-n3omlvfl 34 9 containing contain VBG cord-007714-n3omlvfl 34 10 the the DT cord-007714-n3omlvfl 34 11 genomic genomic JJ cord-007714-n3omlvfl 34 12 DNA dna NN cord-007714-n3omlvfl 34 13 and and CC cord-007714-n3omlvfl 34 14 inter inter JJ cord-007714-n3omlvfl 34 15 - - JJ cord-007714-n3omlvfl 34 16 chromatin chromatin JJ cord-007714-n3omlvfl 34 17 domains domain NNS cord-007714-n3omlvfl 34 18 containing contain VBG cord-007714-n3omlvfl 34 19 the the DT cord-007714-n3omlvfl 34 20 machinery machinery NN cord-007714-n3omlvfl 34 21 for for IN cord-007714-n3omlvfl 34 22 gene gene NN cord-007714-n3omlvfl 34 23 expression expression NN cord-007714-n3omlvfl 34 24 and and CC cord-007714-n3omlvfl 34 25 regulation regulation NN cord-007714-n3omlvfl 34 26 processes process NNS cord-007714-n3omlvfl 35 1 ( ( -LRB- cord-007714-n3omlvfl 35 2 Misteli Misteli NNP cord-007714-n3omlvfl 35 3 2005 2005 CD cord-007714-n3omlvfl 35 4 ) ) -RRB- cord-007714-n3omlvfl 35 5 . . . cord-007714-n3omlvfl 36 1 The the DT cord-007714-n3omlvfl 36 2 nucleus nucleus NN cord-007714-n3omlvfl 36 3 contains contain VBZ cord-007714-n3omlvfl 36 4 many many JJ cord-007714-n3omlvfl 36 5 sub sub JJ cord-007714-n3omlvfl 36 6 - - JJ cord-007714-n3omlvfl 36 7 nuclear nuclear JJ cord-007714-n3omlvfl 36 8 structures structure NNS cord-007714-n3omlvfl 36 9 or or CC cord-007714-n3omlvfl 36 10 bodies body NNS cord-007714-n3omlvfl 36 11 that that WDT cord-007714-n3omlvfl 36 12 vary vary VBP cord-007714-n3omlvfl 36 13 in in IN cord-007714-n3omlvfl 36 14 their -PRON- PRP$ cord-007714-n3omlvfl 36 15 components component NNS cord-007714-n3omlvfl 36 16 and and CC cord-007714-n3omlvfl 36 17 functions function NNS cord-007714-n3omlvfl 36 18 ( ( -LRB- cord-007714-n3omlvfl 36 19 Lamond Lamond NNP cord-007714-n3omlvfl 36 20 and and CC cord-007714-n3omlvfl 36 21 Spector Spector NNP cord-007714-n3omlvfl 36 22 2003 2003 CD cord-007714-n3omlvfl 36 23 ; ; : cord-007714-n3omlvfl 36 24 Cioce Cioce NNP cord-007714-n3omlvfl 36 25 and and CC cord-007714-n3omlvfl 36 26 Lamond Lamond NNP cord-007714-n3omlvfl 36 27 2005 2005 CD cord-007714-n3omlvfl 36 28 ; ; : cord-007714-n3omlvfl 36 29 Misteli Misteli NNP cord-007714-n3omlvfl 36 30 2005 2005 CD cord-007714-n3omlvfl 36 31 ; ; : cord-007714-n3omlvfl 36 32 Handwerger Handwerger NNP cord-007714-n3omlvfl 36 33 and and CC cord-007714-n3omlvfl 36 34 Gall Gall NNP cord-007714-n3omlvfl 36 35 2006 2006 CD cord-007714-n3omlvfl 36 36 ) ) -RRB- cord-007714-n3omlvfl 36 37 . . . cord-007714-n3omlvfl 37 1 Such such JJ cord-007714-n3omlvfl 37 2 structures structure NNS cord-007714-n3omlvfl 37 3 , , , cord-007714-n3omlvfl 37 4 rather rather RB cord-007714-n3omlvfl 37 5 than than IN cord-007714-n3omlvfl 37 6 being be VBG cord-007714-n3omlvfl 37 7 fixed fix VBN cord-007714-n3omlvfl 37 8 , , , cord-007714-n3omlvfl 37 9 unchanging unchanging JJ cord-007714-n3omlvfl 37 10 entities entity NNS cord-007714-n3omlvfl 37 11 , , , cord-007714-n3omlvfl 37 12 reflect reflect VBP cord-007714-n3omlvfl 37 13 the the DT cord-007714-n3omlvfl 37 14 accumulation accumulation NN cord-007714-n3omlvfl 37 15 and and CC cord-007714-n3omlvfl 37 16 steady steady JJ cord-007714-n3omlvfl 37 17 - - HYPH cord-007714-n3omlvfl 37 18 state state NN cord-007714-n3omlvfl 37 19 flux flux NN cord-007714-n3omlvfl 37 20 of of IN cord-007714-n3omlvfl 37 21 sub sub NN cord-007714-n3omlvfl 37 22 - - NNS cord-007714-n3omlvfl 37 23 populations population NNS cord-007714-n3omlvfl 37 24 of of IN cord-007714-n3omlvfl 37 25 molecules molecule NNS cord-007714-n3omlvfl 37 26 and and CC cord-007714-n3omlvfl 37 27 complexes complex NNS cord-007714-n3omlvfl 37 28 , , , cord-007714-n3omlvfl 37 29 as as IN cord-007714-n3omlvfl 37 30 has have VBZ cord-007714-n3omlvfl 37 31 been be VBN cord-007714-n3omlvfl 37 32 clearly clearly RB cord-007714-n3omlvfl 37 33 shown show VBN cord-007714-n3omlvfl 37 34 by by IN cord-007714-n3omlvfl 37 35 fluorescence fluorescence NN cord-007714-n3omlvfl 37 36 recovery recovery NN cord-007714-n3omlvfl 37 37 after after IN cord-007714-n3omlvfl 37 38 photobleaching photobleache VBG cord-007714-n3omlvfl 37 39 ( ( -LRB- cord-007714-n3omlvfl 37 40 FRAP FRAP NNP cord-007714-n3omlvfl 37 41 ) ) -RRB- cord-007714-n3omlvfl 37 42 studies study NNS cord-007714-n3omlvfl 37 43 . . . cord-007714-n3omlvfl 38 1 Their -PRON- PRP$ cord-007714-n3omlvfl 38 2 dynamic dynamic JJ cord-007714-n3omlvfl 38 3 nature nature NN cord-007714-n3omlvfl 38 4 is be VBZ cord-007714-n3omlvfl 38 5 also also RB cord-007714-n3omlvfl 38 6 demonstrated demonstrate VBN cord-007714-n3omlvfl 38 7 by by IN cord-007714-n3omlvfl 38 8 changes change NNS cord-007714-n3omlvfl 38 9 in in IN cord-007714-n3omlvfl 38 10 size size NN cord-007714-n3omlvfl 38 11 and and CC cord-007714-n3omlvfl 38 12 distribution distribution NN cord-007714-n3omlvfl 38 13 under under IN cord-007714-n3omlvfl 38 14 different different JJ cord-007714-n3omlvfl 38 15 conditions condition NNS cord-007714-n3omlvfl 38 16 and and CC cord-007714-n3omlvfl 38 17 during during IN cord-007714-n3omlvfl 38 18 differentiation differentiation NN cord-007714-n3omlvfl 38 19 and and CC cord-007714-n3omlvfl 38 20 development development NN cord-007714-n3omlvfl 38 21 reflecting reflect VBG cord-007714-n3omlvfl 38 22 the the DT cord-007714-n3omlvfl 38 23 high high JJ cord-007714-n3omlvfl 38 24 mobility mobility NN cord-007714-n3omlvfl 38 25 and and CC cord-007714-n3omlvfl 38 26 trafficking trafficking NN cord-007714-n3omlvfl 38 27 of of IN cord-007714-n3omlvfl 38 28 many many JJ cord-007714-n3omlvfl 38 29 components component NNS cord-007714-n3omlvfl 38 30 between between IN cord-007714-n3omlvfl 38 31 the the DT cord-007714-n3omlvfl 38 32 different different JJ cord-007714-n3omlvfl 38 33 bodies body NNS cord-007714-n3omlvfl 38 34 and and CC cord-007714-n3omlvfl 38 35 nucleoplasm nucleoplasm NN cord-007714-n3omlvfl 38 36 ( ( -LRB- cord-007714-n3omlvfl 38 37 Boudonck Boudonck NNP cord-007714-n3omlvfl 38 38 et et FW cord-007714-n3omlvfl 38 39 al al NNP cord-007714-n3omlvfl 38 40 . . . cord-007714-n3omlvfl 39 1 1998 1998 CD cord-007714-n3omlvfl 40 1 ( ( -LRB- cord-007714-n3omlvfl 40 2 Boudonck Boudonck NNP cord-007714-n3omlvfl 40 3 et et FW cord-007714-n3omlvfl 40 4 al al NNP cord-007714-n3omlvfl 40 5 . . NNP cord-007714-n3omlvfl 40 6 , , , cord-007714-n3omlvfl 41 1 1999 1999 CD cord-007714-n3omlvfl 41 2 Lamond Lamond NNP cord-007714-n3omlvfl 41 3 and and CC cord-007714-n3omlvfl 41 4 Spector Spector NNP cord-007714-n3omlvfl 41 5 2003 2003 CD cord-007714-n3omlvfl 41 6 ; ; : cord-007714-n3omlvfl 41 7 Cioce Cioce NNP cord-007714-n3omlvfl 41 8 and and CC cord-007714-n3omlvfl 41 9 Lamond Lamond NNP cord-007714-n3omlvfl 41 10 2005 2005 CD cord-007714-n3omlvfl 41 11 ; ; : cord-007714-n3omlvfl 41 12 Misteli Misteli NNP cord-007714-n3omlvfl 41 13 2005 2005 CD cord-007714-n3omlvfl 41 14 ; ; : cord-007714-n3omlvfl 41 15 Handwerger Handwerger NNP cord-007714-n3omlvfl 41 16 and and CC cord-007714-n3omlvfl 41 17 Gall Gall NNP cord-007714-n3omlvfl 41 18 2006 2006 CD cord-007714-n3omlvfl 41 19 ; ; : cord-007714-n3omlvfl 41 20 Gorski Gorski NNP cord-007714-n3omlvfl 41 21 et et NNP cord-007714-n3omlvfl 41 22 al al NNP cord-007714-n3omlvfl 41 23 . . . cord-007714-n3omlvfl 41 24 2006 2006 CD cord-007714-n3omlvfl 41 25 ; ; : cord-007714-n3omlvfl 41 26 Raška Raška NNP cord-007714-n3omlvfl 41 27 et et NNP cord-007714-n3omlvfl 41 28 al al NNP cord-007714-n3omlvfl 41 29 . . . cord-007714-n3omlvfl 41 30 2006 2006 CD cord-007714-n3omlvfl 41 31 ) ) -RRB- cord-007714-n3omlvfl 41 32 . . . cord-007714-n3omlvfl 42 1 Although although IN cord-007714-n3omlvfl 42 2 the the DT cord-007714-n3omlvfl 42 3 functions function NNS cord-007714-n3omlvfl 42 4 of of IN cord-007714-n3omlvfl 42 5 many many JJ cord-007714-n3omlvfl 42 6 nuclear nuclear JJ cord-007714-n3omlvfl 42 7 bodies body NNS cord-007714-n3omlvfl 42 8 have have VBP cord-007714-n3omlvfl 42 9 yet yet RB cord-007714-n3omlvfl 42 10 to to TO cord-007714-n3omlvfl 42 11 be be VB cord-007714-n3omlvfl 42 12 fully fully RB cord-007714-n3omlvfl 42 13 elucidated elucidate VBN cord-007714-n3omlvfl 42 14 , , , cord-007714-n3omlvfl 42 15 clearly clearly RB cord-007714-n3omlvfl 42 16 some some DT cord-007714-n3omlvfl 42 17 nuclear nuclear JJ cord-007714-n3omlvfl 42 18 bodies body NNS cord-007714-n3omlvfl 42 19 have have VBP cord-007714-n3omlvfl 42 20 multiple multiple JJ cord-007714-n3omlvfl 42 21 functions function NNS cord-007714-n3omlvfl 42 22 and and CC cord-007714-n3omlvfl 42 23 some some DT cord-007714-n3omlvfl 42 24 functions function NNS cord-007714-n3omlvfl 42 25 may may MD cord-007714-n3omlvfl 42 26 overlap overlap VB cord-007714-n3omlvfl 42 27 . . . cord-007714-n3omlvfl 43 1 Thus thus RB cord-007714-n3omlvfl 43 2 the the DT cord-007714-n3omlvfl 43 3 spatial spatial JJ cord-007714-n3omlvfl 43 4 and and CC cord-007714-n3omlvfl 43 5 temporal temporal JJ cord-007714-n3omlvfl 43 6 organisation organisation NN cord-007714-n3omlvfl 43 7 of of IN cord-007714-n3omlvfl 43 8 the the DT cord-007714-n3omlvfl 43 9 nucleus nucleus NN cord-007714-n3omlvfl 43 10 is be VBZ cord-007714-n3omlvfl 43 11 highly highly RB cord-007714-n3omlvfl 43 12 dynamic dynamic JJ cord-007714-n3omlvfl 43 13 and and CC cord-007714-n3omlvfl 43 14 is be VBZ cord-007714-n3omlvfl 43 15 integral integral JJ cord-007714-n3omlvfl 43 16 to to IN cord-007714-n3omlvfl 43 17 the the DT cord-007714-n3omlvfl 43 18 regulation regulation NN cord-007714-n3omlvfl 43 19 and and CC cord-007714-n3omlvfl 43 20 integration integration NN cord-007714-n3omlvfl 43 21 of of IN cord-007714-n3omlvfl 43 22 networks network NNS cord-007714-n3omlvfl 43 23 of of IN cord-007714-n3omlvfl 43 24 gene gene NN cord-007714-n3omlvfl 43 25 expression expression NN cord-007714-n3omlvfl 43 26 processes process NNS cord-007714-n3omlvfl 43 27 which which WDT cord-007714-n3omlvfl 43 28 ultimately ultimately RB cord-007714-n3omlvfl 43 29 determine determine VBP cord-007714-n3omlvfl 43 30 cellular cellular JJ cord-007714-n3omlvfl 43 31 function function NN cord-007714-n3omlvfl 43 32 . . . cord-007714-n3omlvfl 44 1 Consistent consistent JJ cord-007714-n3omlvfl 44 2 with with IN cord-007714-n3omlvfl 44 3 these these DT cord-007714-n3omlvfl 44 4 considerations consideration NNS cord-007714-n3omlvfl 44 5 , , , cord-007714-n3omlvfl 44 6 the the DT cord-007714-n3omlvfl 44 7 nucleolus nucleolus NN cord-007714-n3omlvfl 44 8 , , , cord-007714-n3omlvfl 44 9 already already RB cord-007714-n3omlvfl 44 10 recognised recognise VBN cord-007714-n3omlvfl 44 11 as as RB cord-007714-n3omlvfl 44 12 multifunctional multifunctional JJ cord-007714-n3omlvfl 44 13 , , , cord-007714-n3omlvfl 44 14 continues continue VBZ cord-007714-n3omlvfl 44 15 to to TO cord-007714-n3omlvfl 44 16 add add VB cord-007714-n3omlvfl 44 17 to to IN cord-007714-n3omlvfl 44 18 its -PRON- PRP$ cord-007714-n3omlvfl 44 19 list list NN cord-007714-n3omlvfl 44 20 of of IN cord-007714-n3omlvfl 44 21 functions function NNS cord-007714-n3omlvfl 44 22 and and CC cord-007714-n3omlvfl 44 23 emerges emerge VBZ cord-007714-n3omlvfl 44 24 as as IN cord-007714-n3omlvfl 44 25 a a DT cord-007714-n3omlvfl 44 26 dynamic dynamic JJ cord-007714-n3omlvfl 44 27 and and CC cord-007714-n3omlvfl 44 28 major major JJ cord-007714-n3omlvfl 44 29 centre centre NN cord-007714-n3omlvfl 44 30 for for IN cord-007714-n3omlvfl 44 31 RNA RNA NNP cord-007714-n3omlvfl 44 32 metabolism metabolism NN cord-007714-n3omlvfl 44 33 in in IN cord-007714-n3omlvfl 44 34 the the DT cord-007714-n3omlvfl 44 35 cell cell NN cord-007714-n3omlvfl 44 36 . . . cord-007714-n3omlvfl 45 1 The the DT cord-007714-n3omlvfl 45 2 nucleolus nucleolus NN cord-007714-n3omlvfl 45 3 is be VBZ cord-007714-n3omlvfl 45 4 not not RB cord-007714-n3omlvfl 45 5 membrane membrane NN cord-007714-n3omlvfl 45 6 - - HYPH cord-007714-n3omlvfl 45 7 bound bind VBN cord-007714-n3omlvfl 45 8 , , , cord-007714-n3omlvfl 45 9 has have VBZ cord-007714-n3omlvfl 45 10 a a DT cord-007714-n3omlvfl 45 11 high high JJ cord-007714-n3omlvfl 45 12 relative relative JJ cord-007714-n3omlvfl 45 13 refractive refractive JJ cord-007714-n3omlvfl 45 14 index index NN cord-007714-n3omlvfl 45 15 and and CC cord-007714-n3omlvfl 45 16 thus thus RB cord-007714-n3omlvfl 45 17 appears appear VBZ cord-007714-n3omlvfl 45 18 under under IN cord-007714-n3omlvfl 45 19 phase phase NN cord-007714-n3omlvfl 45 20 contrast contrast NN cord-007714-n3omlvfl 45 21 microscopy microscopy NNS cord-007714-n3omlvfl 45 22 as as IN cord-007714-n3omlvfl 45 23 a a DT cord-007714-n3omlvfl 45 24 dense dense JJ cord-007714-n3omlvfl 45 25 region region NN cord-007714-n3omlvfl 45 26 of of IN cord-007714-n3omlvfl 45 27 the the DT cord-007714-n3omlvfl 45 28 nucleus nucleus NN cord-007714-n3omlvfl 45 29 . . . cord-007714-n3omlvfl 46 1 It -PRON- PRP cord-007714-n3omlvfl 46 2 is be VBZ cord-007714-n3omlvfl 46 3 formed form VBN cord-007714-n3omlvfl 46 4 around around IN cord-007714-n3omlvfl 46 5 tens ten NNS cord-007714-n3omlvfl 46 6 , , , cord-007714-n3omlvfl 46 7 hundreds hundred NNS cord-007714-n3omlvfl 46 8 or or CC cord-007714-n3omlvfl 46 9 even even RB cord-007714-n3omlvfl 46 10 thousands thousand NNS cord-007714-n3omlvfl 46 11 of of IN cord-007714-n3omlvfl 46 12 tandemly tandemly NN cord-007714-n3omlvfl 46 13 repeated repeat VBN cord-007714-n3omlvfl 46 14 ribosomal ribosomal NNP cord-007714-n3omlvfl 46 15 RNA RNA NNP cord-007714-n3omlvfl 46 16 ( ( -LRB- cord-007714-n3omlvfl 46 17 rRNA rRNA NNP cord-007714-n3omlvfl 46 18 ) ) -RRB- cord-007714-n3omlvfl 46 19 gene gene NN cord-007714-n3omlvfl 46 20 units unit NNS cord-007714-n3omlvfl 46 21 and and CC cord-007714-n3omlvfl 46 22 contains contain VBZ cord-007714-n3omlvfl 46 23 rRNA rrna NN cord-007714-n3omlvfl 46 24 transcripts transcript NNS cord-007714-n3omlvfl 46 25 at at IN cord-007714-n3omlvfl 46 26 different different JJ cord-007714-n3omlvfl 46 27 stages stage NNS cord-007714-n3omlvfl 46 28 of of IN cord-007714-n3omlvfl 46 29 transcription transcription NN cord-007714-n3omlvfl 46 30 , , , cord-007714-n3omlvfl 46 31 processing processing NN cord-007714-n3omlvfl 46 32 and and CC cord-007714-n3omlvfl 46 33 assembly assembly NN cord-007714-n3omlvfl 46 34 into into IN cord-007714-n3omlvfl 46 35 ribosomal ribosomal JJ cord-007714-n3omlvfl 46 36 subunits subunit NNS cord-007714-n3omlvfl 46 37 and and CC cord-007714-n3omlvfl 46 38 the the DT cord-007714-n3omlvfl 46 39 multitude multitude NN cord-007714-n3omlvfl 46 40 of of IN cord-007714-n3omlvfl 46 41 RNAs rna NNS cord-007714-n3omlvfl 46 42 and and CC cord-007714-n3omlvfl 46 43 proteins protein NNS cord-007714-n3omlvfl 46 44 required require VBN cord-007714-n3omlvfl 46 45 for for IN cord-007714-n3omlvfl 46 46 these these DT cord-007714-n3omlvfl 46 47 processes process NNS cord-007714-n3omlvfl 46 48 . . . cord-007714-n3omlvfl 47 1 The the DT cord-007714-n3omlvfl 47 2 observed observed JJ cord-007714-n3omlvfl 47 3 nucleolar nucleolar JJ cord-007714-n3omlvfl 47 4 compartment compartment NN cord-007714-n3omlvfl 47 5 therefore therefore RB cord-007714-n3omlvfl 47 6 represents represent VBZ cord-007714-n3omlvfl 47 7 a a DT cord-007714-n3omlvfl 47 8 snapshot snapshot NN cord-007714-n3omlvfl 47 9 of of IN cord-007714-n3omlvfl 47 10 the the DT cord-007714-n3omlvfl 47 11 steady steady JJ cord-007714-n3omlvfl 47 12 - - HYPH cord-007714-n3omlvfl 47 13 state state NN cord-007714-n3omlvfl 47 14 import import NN cord-007714-n3omlvfl 47 15 of of IN cord-007714-n3omlvfl 47 16 components component NNS cord-007714-n3omlvfl 47 17 and and CC cord-007714-n3omlvfl 47 18 export export NN cord-007714-n3omlvfl 47 19 of of IN cord-007714-n3omlvfl 47 20 the the DT cord-007714-n3omlvfl 47 21 major major JJ cord-007714-n3omlvfl 47 22 products product NNS cord-007714-n3omlvfl 47 23 , , , cord-007714-n3omlvfl 47 24 the the DT cord-007714-n3omlvfl 47 25 ribosomal ribosomal JJ cord-007714-n3omlvfl 47 26 subunits subunit NNS cord-007714-n3omlvfl 47 27 ( ( -LRB- cord-007714-n3omlvfl 47 28 Leung Leung NNP cord-007714-n3omlvfl 47 29 and and CC cord-007714-n3omlvfl 47 30 Lamond Lamond NNP cord-007714-n3omlvfl 47 31 2003 2003 CD cord-007714-n3omlvfl 47 32 ; ; : cord-007714-n3omlvfl 47 33 Cheutin Cheutin NNP cord-007714-n3omlvfl 47 34 et et FW cord-007714-n3omlvfl 47 35 al al NNP cord-007714-n3omlvfl 47 36 . . . cord-007714-n3omlvfl 47 37 2004 2004 CD cord-007714-n3omlvfl 47 38 ) ) -RRB- cord-007714-n3omlvfl 47 39 . . . cord-007714-n3omlvfl 48 1 The the DT cord-007714-n3omlvfl 48 2 fundamental fundamental JJ cord-007714-n3omlvfl 48 3 role role NN cord-007714-n3omlvfl 48 4 of of IN cord-007714-n3omlvfl 48 5 the the DT cord-007714-n3omlvfl 48 6 nucleolus nucleolus NN cord-007714-n3omlvfl 48 7 in in IN cord-007714-n3omlvfl 48 8 production production NN cord-007714-n3omlvfl 48 9 of of IN cord-007714-n3omlvfl 48 10 ribosomes ribosome NNS cord-007714-n3omlvfl 48 11 needed need VBN cord-007714-n3omlvfl 48 12 for for IN cord-007714-n3omlvfl 48 13 translation translation NN cord-007714-n3omlvfl 48 14 is be VBZ cord-007714-n3omlvfl 48 15 also also RB cord-007714-n3omlvfl 48 16 reflected reflect VBN cord-007714-n3omlvfl 48 17 in in IN cord-007714-n3omlvfl 48 18 the the DT cord-007714-n3omlvfl 48 19 effects effect NNS cord-007714-n3omlvfl 48 20 on on IN cord-007714-n3omlvfl 48 21 rRNA rRNA NNP cord-007714-n3omlvfl 48 22 transcription transcription NN cord-007714-n3omlvfl 48 23 , , , cord-007714-n3omlvfl 48 24 ribosome ribosome NN cord-007714-n3omlvfl 48 25 production production NN cord-007714-n3omlvfl 48 26 and and CC cord-007714-n3omlvfl 48 27 nucleolar nucleolar JJ cord-007714-n3omlvfl 48 28 morphology morphology NN cord-007714-n3omlvfl 48 29 of of IN cord-007714-n3omlvfl 48 30 cell cell NN cord-007714-n3omlvfl 48 31 growth growth NN cord-007714-n3omlvfl 48 32 and and CC cord-007714-n3omlvfl 48 33 environmental environmental JJ cord-007714-n3omlvfl 48 34 conditions condition NNS cord-007714-n3omlvfl 49 1 ( ( -LRB- cord-007714-n3omlvfl 49 2 Leung Leung NNP cord-007714-n3omlvfl 49 3 and and CC cord-007714-n3omlvfl 49 4 Lamond Lamond NNP cord-007714-n3omlvfl 49 5 2003 2003 CD cord-007714-n3omlvfl 49 6 ; ; : cord-007714-n3omlvfl 49 7 Leung Leung NNP cord-007714-n3omlvfl 49 8 et et NNP cord-007714-n3omlvfl 49 9 al al NNP cord-007714-n3omlvfl 49 10 . . . cord-007714-n3omlvfl 50 1 2004 2004 CD cord-007714-n3omlvfl 50 2 ; ; : cord-007714-n3omlvfl 50 3 Mosgoeller Mosgoeller NNP cord-007714-n3omlvfl 50 4 2004 2004 CD cord-007714-n3omlvfl 50 5 ; ; : cord-007714-n3omlvfl 50 6 Dove Dove NNP cord-007714-n3omlvfl 50 7 et et FW cord-007714-n3omlvfl 50 8 al al NNP cord-007714-n3omlvfl 50 9 . . . cord-007714-n3omlvfl 51 1 2006 2006 CD cord-007714-n3omlvfl 51 2 ; ; : cord-007714-n3omlvfl 51 3 Raška Raška NNP cord-007714-n3omlvfl 51 4 et et NNP cord-007714-n3omlvfl 51 5 al al NNP cord-007714-n3omlvfl 51 6 . . . cord-007714-n3omlvfl 51 7 2006 2006 CD cord-007714-n3omlvfl 51 8 ) ) -RRB- cord-007714-n3omlvfl 51 9 . . . cord-007714-n3omlvfl 52 1 This this DT cord-007714-n3omlvfl 52 2 integral integral JJ cord-007714-n3omlvfl 52 3 link link NN cord-007714-n3omlvfl 52 4 between between IN cord-007714-n3omlvfl 52 5 the the DT cord-007714-n3omlvfl 52 6 nucleolus nucleolus NN cord-007714-n3omlvfl 52 7 and and CC cord-007714-n3omlvfl 52 8 normal normal JJ cord-007714-n3omlvfl 52 9 functioning functioning NN cord-007714-n3omlvfl 52 10 of of IN cord-007714-n3omlvfl 52 11 the the DT cord-007714-n3omlvfl 52 12 cell cell NN cord-007714-n3omlvfl 52 13 is be VBZ cord-007714-n3omlvfl 52 14 further further RB cord-007714-n3omlvfl 52 15 highlighted highlight VBN cord-007714-n3omlvfl 52 16 by by IN cord-007714-n3omlvfl 52 17 its -PRON- PRP$ cord-007714-n3omlvfl 52 18 involvement involvement NN cord-007714-n3omlvfl 52 19 in in IN cord-007714-n3omlvfl 52 20 cell cell NN cord-007714-n3omlvfl 52 21 division division NN cord-007714-n3omlvfl 52 22 , , , cord-007714-n3omlvfl 52 23 cell cell NN cord-007714-n3omlvfl 52 24 death death NN cord-007714-n3omlvfl 52 25 and and CC cord-007714-n3omlvfl 52 26 stress stress NN cord-007714-n3omlvfl 52 27 responses response NNS cord-007714-n3omlvfl 52 28 ( ( -LRB- cord-007714-n3omlvfl 52 29 Rubbi Rubbi NNP cord-007714-n3omlvfl 52 30 and and CC cord-007714-n3omlvfl 52 31 Milner Milner NNP cord-007714-n3omlvfl 52 32 2003 2003 CD cord-007714-n3omlvfl 52 33 ; ; : cord-007714-n3omlvfl 52 34 Olsen Olsen NNP cord-007714-n3omlvfl 52 35 2004 2004 CD cord-007714-n3omlvfl 52 36 ; ; : cord-007714-n3omlvfl 52 37 Raška Raška NNP cord-007714-n3omlvfl 52 38 et et FW cord-007714-n3omlvfl 52 39 al al NNP cord-007714-n3omlvfl 52 40 . . . cord-007714-n3omlvfl 53 1 2006 2006 CD cord-007714-n3omlvfl 53 2 ; ; : cord-007714-n3omlvfl 53 3 Boisvert Boisvert NNP cord-007714-n3omlvfl 53 4 et et NNP cord-007714-n3omlvfl 53 5 al al NNP cord-007714-n3omlvfl 53 6 . . NNP cord-007714-n3omlvfl 53 7 2007 2007 CD cord-007714-n3omlvfl 53 8 ) ) -RRB- cord-007714-n3omlvfl 53 9 . . . cord-007714-n3omlvfl 54 1 In in IN cord-007714-n3omlvfl 54 2 addition addition NN cord-007714-n3omlvfl 54 3 to to IN cord-007714-n3omlvfl 54 4 the the DT cord-007714-n3omlvfl 54 5 factors factor NNS cord-007714-n3omlvfl 54 6 required require VBN cord-007714-n3omlvfl 54 7 for for IN cord-007714-n3omlvfl 54 8 ribosome ribosome NN cord-007714-n3omlvfl 54 9 biogenesis biogenesis NN cord-007714-n3omlvfl 54 10 , , , cord-007714-n3omlvfl 54 11 the the DT cord-007714-n3omlvfl 54 12 nucleolus nucleolus NN cord-007714-n3omlvfl 54 13 also also RB cord-007714-n3omlvfl 54 14 functions function VBZ cord-007714-n3omlvfl 54 15 in in IN cord-007714-n3omlvfl 54 16 aspects aspect NNS cord-007714-n3omlvfl 54 17 of of IN cord-007714-n3omlvfl 54 18 the the DT cord-007714-n3omlvfl 54 19 biogenesis biogenesis NN cord-007714-n3omlvfl 54 20 of of IN cord-007714-n3omlvfl 54 21 many many JJ cord-007714-n3omlvfl 54 22 other other JJ cord-007714-n3omlvfl 54 23 RNP RNP NNP cord-007714-n3omlvfl 54 24 complexes complex NNS cord-007714-n3omlvfl 54 25 and and CC cord-007714-n3omlvfl 54 26 contains contain VBZ cord-007714-n3omlvfl 54 27 proteins protein NNS cord-007714-n3omlvfl 54 28 and and CC cord-007714-n3omlvfl 54 29 protein protein NN cord-007714-n3omlvfl 54 30 complexes complex NNS cord-007714-n3omlvfl 54 31 involved involve VBN cord-007714-n3omlvfl 54 32 in in IN cord-007714-n3omlvfl 54 33 a a DT cord-007714-n3omlvfl 54 34 range range NN cord-007714-n3omlvfl 54 35 of of IN cord-007714-n3omlvfl 54 36 cellular cellular JJ cord-007714-n3omlvfl 54 37 functions function NNS cord-007714-n3omlvfl 54 38 as as IN cord-007714-n3omlvfl 54 39 detailed detail VBN cord-007714-n3omlvfl 54 40 below below IN cord-007714-n3omlvfl 54 41 in in IN cord-007714-n3omlvfl 54 42 this this DT cord-007714-n3omlvfl 54 43 review review NN cord-007714-n3omlvfl 54 44 . . . cord-007714-n3omlvfl 55 1 Besides besides IN cord-007714-n3omlvfl 55 2 the the DT cord-007714-n3omlvfl 55 3 nucleolus nucleolus NN cord-007714-n3omlvfl 55 4 , , , cord-007714-n3omlvfl 55 5 other other JJ cord-007714-n3omlvfl 55 6 nuclear nuclear JJ cord-007714-n3omlvfl 55 7 bodies body NNS cord-007714-n3omlvfl 55 8 such such JJ cord-007714-n3omlvfl 55 9 as as IN cord-007714-n3omlvfl 55 10 Cajal Cajal NNP cord-007714-n3omlvfl 55 11 bodies body NNS cord-007714-n3omlvfl 55 12 ( ( -LRB- cord-007714-n3omlvfl 55 13 CBs CBs NNP cord-007714-n3omlvfl 55 14 ) ) -RRB- cord-007714-n3omlvfl 55 15 and and CC cord-007714-n3omlvfl 55 16 speckles speckle NNS cord-007714-n3omlvfl 55 17 have have VBP cord-007714-n3omlvfl 55 18 been be VBN cord-007714-n3omlvfl 55 19 identified identify VBN cord-007714-n3omlvfl 55 20 in in IN cord-007714-n3omlvfl 55 21 animal animal NN cord-007714-n3omlvfl 55 22 and and CC cord-007714-n3omlvfl 55 23 plant plant NN cord-007714-n3omlvfl 55 24 nuclei nucleus NNS cord-007714-n3omlvfl 55 25 ( ( -LRB- cord-007714-n3omlvfl 55 26 Cioce Cioce NNP cord-007714-n3omlvfl 55 27 and and CC cord-007714-n3omlvfl 55 28 Lamond Lamond NNP cord-007714-n3omlvfl 55 29 2005 2005 CD cord-007714-n3omlvfl 55 30 ; ; : cord-007714-n3omlvfl 55 31 Handwerger Handwerger NNP cord-007714-n3omlvfl 55 32 and and CC cord-007714-n3omlvfl 55 33 Gall Gall NNP cord-007714-n3omlvfl 55 34 2006 2006 CD cord-007714-n3omlvfl 55 35 ) ) -RRB- cord-007714-n3omlvfl 55 36 . . . cord-007714-n3omlvfl 56 1 In in IN cord-007714-n3omlvfl 56 2 particular particular JJ cord-007714-n3omlvfl 56 3 , , , cord-007714-n3omlvfl 56 4 CBs CBs NNP cord-007714-n3omlvfl 56 5 , , , cord-007714-n3omlvfl 56 6 which which WDT cord-007714-n3omlvfl 56 7 are be VBP cord-007714-n3omlvfl 56 8 often often RB cord-007714-n3omlvfl 56 9 closely closely RB cord-007714-n3omlvfl 56 10 associated associate VBN cord-007714-n3omlvfl 56 11 with with IN cord-007714-n3omlvfl 56 12 nucleoli nucleoli NNP cord-007714-n3omlvfl 56 13 , , , cord-007714-n3omlvfl 56 14 contain contain VBP cord-007714-n3omlvfl 56 15 a a DT cord-007714-n3omlvfl 56 16 number number NN cord-007714-n3omlvfl 56 17 of of IN cord-007714-n3omlvfl 56 18 different different JJ cord-007714-n3omlvfl 56 19 proteins protein NNS cord-007714-n3omlvfl 56 20 including include VBG cord-007714-n3omlvfl 56 21 coilin coilin NNP cord-007714-n3omlvfl 56 22 , , , cord-007714-n3omlvfl 56 23 a a DT cord-007714-n3omlvfl 56 24 protein protein NN cord-007714-n3omlvfl 56 25 essential essential JJ cord-007714-n3omlvfl 56 26 for for IN cord-007714-n3omlvfl 56 27 CB CB NNP cord-007714-n3omlvfl 56 28 formation formation NN cord-007714-n3omlvfl 56 29 , , , cord-007714-n3omlvfl 56 30 and and CC cord-007714-n3omlvfl 56 31 fibrillarin fibrillarin NNP cord-007714-n3omlvfl 56 32 and and CC cord-007714-n3omlvfl 56 33 dyskerin dyskerin NNP cord-007714-n3omlvfl 56 34 , , , cord-007714-n3omlvfl 56 35 nucleolar nucleolar JJ cord-007714-n3omlvfl 56 36 proteins protein NNS cord-007714-n3omlvfl 56 37 required require VBN cord-007714-n3omlvfl 56 38 for for IN cord-007714-n3omlvfl 56 39 pre pre JJ cord-007714-n3omlvfl 56 40 - - JJ cord-007714-n3omlvfl 56 41 rRNA rrna JJ cord-007714-n3omlvfl 56 42 processing processing NN cord-007714-n3omlvfl 56 43 and and CC cord-007714-n3omlvfl 56 44 modification modification NN cord-007714-n3omlvfl 56 45 ( ( -LRB- cord-007714-n3omlvfl 56 46 Cioce Cioce NNP cord-007714-n3omlvfl 56 47 and and CC cord-007714-n3omlvfl 56 48 Lamond Lamond NNP cord-007714-n3omlvfl 56 49 2005 2005 CD cord-007714-n3omlvfl 56 50 ) ) -RRB- cord-007714-n3omlvfl 56 51 . . . cord-007714-n3omlvfl 57 1 CBs CBs NNP cord-007714-n3omlvfl 57 2 are be VBP cord-007714-n3omlvfl 57 3 involved involve VBN cord-007714-n3omlvfl 57 4 in in IN cord-007714-n3omlvfl 57 5 the the DT cord-007714-n3omlvfl 57 6 maturation maturation NN cord-007714-n3omlvfl 57 7 of of IN cord-007714-n3omlvfl 57 8 spliceosomal spliceosomal JJ cord-007714-n3omlvfl 57 9 snRNPs snRNPs NNP cord-007714-n3omlvfl 57 10 and and CC cord-007714-n3omlvfl 57 11 snoRNPs snoRNPs NNP cord-007714-n3omlvfl 57 12 , , , cord-007714-n3omlvfl 57 13 with with IN cord-007714-n3omlvfl 57 14 newly newly RB cord-007714-n3omlvfl 57 15 assembled assemble VBN cord-007714-n3omlvfl 57 16 snRNPs snRNPs NNP cord-007714-n3omlvfl 57 17 and and CC cord-007714-n3omlvfl 57 18 snoRNPs snornps RB cord-007714-n3omlvfl 57 19 trafficking traffic VBG cord-007714-n3omlvfl 57 20 through through IN cord-007714-n3omlvfl 57 21 CBs CBs NNP cord-007714-n3omlvfl 57 22 before before IN cord-007714-n3omlvfl 57 23 accumulating accumulate VBG cord-007714-n3omlvfl 57 24 in in IN cord-007714-n3omlvfl 57 25 splicing splice VBG cord-007714-n3omlvfl 57 26 speckles speckle NNS cord-007714-n3omlvfl 57 27 and and CC cord-007714-n3omlvfl 57 28 the the DT cord-007714-n3omlvfl 57 29 nucleolus nucleolus NN cord-007714-n3omlvfl 57 30 , , , cord-007714-n3omlvfl 57 31 respectively respectively RB cord-007714-n3omlvfl 57 32 ( ( -LRB- cord-007714-n3omlvfl 57 33 Narayanan Narayanan NNP cord-007714-n3omlvfl 57 34 et et NNP cord-007714-n3omlvfl 57 35 al al NNP cord-007714-n3omlvfl 57 36 . . . cord-007714-n3omlvfl 58 1 1999 1999 CD cord-007714-n3omlvfl 58 2 ; ; : cord-007714-n3omlvfl 58 3 Sleeman Sleeman NNP cord-007714-n3omlvfl 58 4 and and CC cord-007714-n3omlvfl 58 5 Lamond Lamond NNP cord-007714-n3omlvfl 58 6 1999 1999 CD cord-007714-n3omlvfl 58 7 ) ) -RRB- cord-007714-n3omlvfl 58 8 . . . cord-007714-n3omlvfl 59 1 The the DT cord-007714-n3omlvfl 59 2 modification modification NN cord-007714-n3omlvfl 59 3 of of IN cord-007714-n3omlvfl 59 4 specific specific JJ cord-007714-n3omlvfl 59 5 nucleotides nucleotide NNS cord-007714-n3omlvfl 59 6 in in IN cord-007714-n3omlvfl 59 7 snRNAs snrna NNS cord-007714-n3omlvfl 59 8 , , , cord-007714-n3omlvfl 59 9 guided guide VBN cord-007714-n3omlvfl 59 10 by by IN cord-007714-n3omlvfl 59 11 small small JJ cord-007714-n3omlvfl 59 12 CB cb NN cord-007714-n3omlvfl 59 13 - - HYPH cord-007714-n3omlvfl 59 14 specific specific JJ cord-007714-n3omlvfl 59 15 RNAs rna NNS cord-007714-n3omlvfl 59 16 ( ( -LRB- cord-007714-n3omlvfl 59 17 scaRNAs scaRNAs NNP cord-007714-n3omlvfl 59 18 ) ) -RRB- cord-007714-n3omlvfl 59 19 , , , cord-007714-n3omlvfl 59 20 occurs occur VBZ cord-007714-n3omlvfl 59 21 in in IN cord-007714-n3omlvfl 59 22 CBs CBs NNP cord-007714-n3omlvfl 59 23 ( ( -LRB- cord-007714-n3omlvfl 59 24 Darzacq Darzacq NNP cord-007714-n3omlvfl 59 25 et et FW cord-007714-n3omlvfl 59 26 al al NNP cord-007714-n3omlvfl 59 27 . . . cord-007714-n3omlvfl 59 28 2002 2002 CD cord-007714-n3omlvfl 59 29 ; ; : cord-007714-n3omlvfl 59 30 Jady Jady NNP cord-007714-n3omlvfl 59 31 et et NNP cord-007714-n3omlvfl 59 32 al al NNP cord-007714-n3omlvfl 59 33 . . NNP cord-007714-n3omlvfl 59 34 2003 2003 CD cord-007714-n3omlvfl 59 35 ) ) -RRB- cord-007714-n3omlvfl 59 36 . . . cord-007714-n3omlvfl 60 1 CBs CBs NNP cord-007714-n3omlvfl 60 2 also also RB cord-007714-n3omlvfl 60 3 contain contain VBP cord-007714-n3omlvfl 60 4 U7snRNA u7snrna NN cord-007714-n3omlvfl 60 5 , , , cord-007714-n3omlvfl 60 6 which which WDT cord-007714-n3omlvfl 60 7 functions function VBZ cord-007714-n3omlvfl 60 8 in in IN cord-007714-n3omlvfl 60 9 the the DT cord-007714-n3omlvfl 60 10 3′ 3′ CD cord-007714-n3omlvfl 60 11 end end NN cord-007714-n3omlvfl 60 12 processing processing NN cord-007714-n3omlvfl 60 13 of of IN cord-007714-n3omlvfl 60 14 some some DT cord-007714-n3omlvfl 60 15 histone histone NN cord-007714-n3omlvfl 60 16 mRNAs mRNAs NNPS cord-007714-n3omlvfl 60 17 , , , cord-007714-n3omlvfl 60 18 and and CC cord-007714-n3omlvfl 60 19 are be VBP cord-007714-n3omlvfl 60 20 enriched enrich VBN cord-007714-n3omlvfl 60 21 in in IN cord-007714-n3omlvfl 60 22 the the DT cord-007714-n3omlvfl 60 23 RNA RNA NNP cord-007714-n3omlvfl 60 24 of of IN cord-007714-n3omlvfl 60 25 telomerase telomerase NN cord-007714-n3omlvfl 60 26 RNP RNP NNP cord-007714-n3omlvfl 60 27 ( ( -LRB- cord-007714-n3omlvfl 60 28 Frey Frey NNP cord-007714-n3omlvfl 60 29 and and CC cord-007714-n3omlvfl 60 30 Matera Matera NNP cord-007714-n3omlvfl 60 31 1995 1995 CD cord-007714-n3omlvfl 60 32 ; ; : cord-007714-n3omlvfl 60 33 Jady Jady NNP cord-007714-n3omlvfl 60 34 et et NNP cord-007714-n3omlvfl 60 35 al al NNP cord-007714-n3omlvfl 60 36 . . . cord-007714-n3omlvfl 61 1 2004 2004 CD cord-007714-n3omlvfl 61 2 ; ; : cord-007714-n3omlvfl 61 3 Zhu Zhu NNP cord-007714-n3omlvfl 61 4 et et FW cord-007714-n3omlvfl 61 5 al al NNP cord-007714-n3omlvfl 61 6 . . . cord-007714-n3omlvfl 62 1 2004 2004 CD cord-007714-n3omlvfl 62 2 ; ; : cord-007714-n3omlvfl 62 3 Pillai Pillai NNP cord-007714-n3omlvfl 62 4 et et NNP cord-007714-n3omlvfl 62 5 al al NNP cord-007714-n3omlvfl 62 6 . . NNP cord-007714-n3omlvfl 62 7 2005 2005 CD cord-007714-n3omlvfl 62 8 ) ) -RRB- cord-007714-n3omlvfl 62 9 . . . cord-007714-n3omlvfl 63 1 CBs CBs NNP cord-007714-n3omlvfl 63 2 are be VBP cord-007714-n3omlvfl 63 3 dynamic dynamic JJ cord-007714-n3omlvfl 63 4 structures structure NNS cord-007714-n3omlvfl 63 5 whose whose WP$ cord-007714-n3omlvfl 63 6 presence presence NN cord-007714-n3omlvfl 63 7 and and CC cord-007714-n3omlvfl 63 8 abundance abundance NN cord-007714-n3omlvfl 63 9 are be VBP cord-007714-n3omlvfl 63 10 linked link VBN cord-007714-n3omlvfl 63 11 to to IN cord-007714-n3omlvfl 63 12 the the DT cord-007714-n3omlvfl 63 13 transcriptional transcriptional JJ cord-007714-n3omlvfl 63 14 activity activity NN cord-007714-n3omlvfl 63 15 of of IN cord-007714-n3omlvfl 63 16 the the DT cord-007714-n3omlvfl 63 17 cell cell NN cord-007714-n3omlvfl 63 18 and and CC cord-007714-n3omlvfl 63 19 their -PRON- PRP$ cord-007714-n3omlvfl 63 20 association association NN cord-007714-n3omlvfl 63 21 with with IN cord-007714-n3omlvfl 63 22 the the DT cord-007714-n3omlvfl 63 23 nucleolus nucleolus NN cord-007714-n3omlvfl 63 24 is be VBZ cord-007714-n3omlvfl 63 25 reflected reflect VBN cord-007714-n3omlvfl 63 26 in in IN cord-007714-n3omlvfl 63 27 the the DT cord-007714-n3omlvfl 63 28 trafficking trafficking NN cord-007714-n3omlvfl 63 29 of of IN cord-007714-n3omlvfl 63 30 nucleolar nucleolar JJ cord-007714-n3omlvfl 63 31 proteins protein NNS cord-007714-n3omlvfl 63 32 between between IN cord-007714-n3omlvfl 63 33 the the DT cord-007714-n3omlvfl 63 34 nucleolus nucleolus NN cord-007714-n3omlvfl 63 35 and and CC cord-007714-n3omlvfl 63 36 CBs CBs NNP cord-007714-n3omlvfl 63 37 . . . cord-007714-n3omlvfl 64 1 Thus thus RB cord-007714-n3omlvfl 64 2 nucleoli nucleoli NNP cord-007714-n3omlvfl 64 3 and and CC cord-007714-n3omlvfl 64 4 CBs CBs NNP cord-007714-n3omlvfl 64 5 are be VBP cord-007714-n3omlvfl 64 6 both both RB cord-007714-n3omlvfl 64 7 multifunctional multifunctional JJ cord-007714-n3omlvfl 64 8 and and CC cord-007714-n3omlvfl 64 9 involved involve VBN cord-007714-n3omlvfl 64 10 in in IN cord-007714-n3omlvfl 64 11 RNP RNP NNP cord-007714-n3omlvfl 64 12 maturation maturation NN cord-007714-n3omlvfl 64 13 . . . cord-007714-n3omlvfl 65 1 In in IN cord-007714-n3omlvfl 65 2 plants plant NNS cord-007714-n3omlvfl 65 3 , , , cord-007714-n3omlvfl 65 4 the the DT cord-007714-n3omlvfl 65 5 best well RBS cord-007714-n3omlvfl 65 6 - - HYPH cord-007714-n3omlvfl 65 7 characterised characterise VBN cord-007714-n3omlvfl 65 8 nuclear nuclear JJ cord-007714-n3omlvfl 65 9 bodies body NNS cord-007714-n3omlvfl 65 10 are be VBP cord-007714-n3omlvfl 65 11 the the DT cord-007714-n3omlvfl 65 12 nucleolus nucleolus NN cord-007714-n3omlvfl 65 13 and and CC cord-007714-n3omlvfl 65 14 CBs CBs NNP cord-007714-n3omlvfl 65 15 . . . cord-007714-n3omlvfl 66 1 The the DT cord-007714-n3omlvfl 66 2 plant plant NN cord-007714-n3omlvfl 66 3 nucleolus nucleolus NN cord-007714-n3omlvfl 66 4 differs differ VBZ cord-007714-n3omlvfl 66 5 to to IN cord-007714-n3omlvfl 66 6 some some DT cord-007714-n3omlvfl 66 7 extent extent NN cord-007714-n3omlvfl 66 8 in in IN cord-007714-n3omlvfl 66 9 organisation organisation NN cord-007714-n3omlvfl 66 10 and and CC cord-007714-n3omlvfl 66 11 structure structure NN cord-007714-n3omlvfl 66 12 from from IN cord-007714-n3omlvfl 66 13 the the DT cord-007714-n3omlvfl 66 14 animal animal NN cord-007714-n3omlvfl 66 15 nucleolus nucleolus NN cord-007714-n3omlvfl 66 16 , , , cord-007714-n3omlvfl 66 17 although although IN cord-007714-n3omlvfl 66 18 its -PRON- PRP$ cord-007714-n3omlvfl 66 19 major major JJ cord-007714-n3omlvfl 66 20 function function NN cord-007714-n3omlvfl 66 21 in in IN cord-007714-n3omlvfl 66 22 rRNA rrna NN cord-007714-n3omlvfl 66 23 and and CC cord-007714-n3omlvfl 66 24 ribosomal ribosomal JJ cord-007714-n3omlvfl 66 25 subunit subunit NN cord-007714-n3omlvfl 66 26 production production NN cord-007714-n3omlvfl 66 27 remains remain VBZ cord-007714-n3omlvfl 66 28 the the DT cord-007714-n3omlvfl 66 29 same same JJ cord-007714-n3omlvfl 66 30 Shaw Shaw NNP cord-007714-n3omlvfl 66 31 and and CC cord-007714-n3omlvfl 66 32 Brown Brown NNP cord-007714-n3omlvfl 66 33 2004 2004 CD cord-007714-n3omlvfl 66 34 ) ) -RRB- cord-007714-n3omlvfl 66 35 . . . cord-007714-n3omlvfl 67 1 The the DT cord-007714-n3omlvfl 67 2 plant plant NN cord-007714-n3omlvfl 67 3 nucleolus nucleolus NN cord-007714-n3omlvfl 67 4 contains contain VBZ cord-007714-n3omlvfl 67 5 a a DT cord-007714-n3omlvfl 67 6 large large JJ cord-007714-n3omlvfl 67 7 proportion proportion NN cord-007714-n3omlvfl 67 8 of of IN cord-007714-n3omlvfl 67 9 dense dense JJ cord-007714-n3omlvfl 67 10 fibrillar fibrillar JJ cord-007714-n3omlvfl 67 11 component component NN cord-007714-n3omlvfl 67 12 ( ( -LRB- cord-007714-n3omlvfl 67 13 DFC DFC NNP cord-007714-n3omlvfl 67 14 ) ) -RRB- cord-007714-n3omlvfl 67 15 , , , cord-007714-n3omlvfl 67 16 much much RB cord-007714-n3omlvfl 67 17 more more JJR cord-007714-n3omlvfl 67 18 than than IN cord-007714-n3omlvfl 67 19 in in IN cord-007714-n3omlvfl 67 20 typical typical JJ cord-007714-n3omlvfl 67 21 animal animal NN cord-007714-n3omlvfl 67 22 nucleoli nucleoli NNP cord-007714-n3omlvfl 67 23 , , , cord-007714-n3omlvfl 67 24 which which WDT cord-007714-n3omlvfl 67 25 is be VBZ cord-007714-n3omlvfl 67 26 surrounded surround VBN cord-007714-n3omlvfl 67 27 by by IN cord-007714-n3omlvfl 67 28 the the DT cord-007714-n3omlvfl 67 29 granular granular JJ cord-007714-n3omlvfl 67 30 component component NN cord-007714-n3omlvfl 67 31 ( ( -LRB- cord-007714-n3omlvfl 67 32 GC GC NNP cord-007714-n3omlvfl 67 33 ) ) -RRB- cord-007714-n3omlvfl 68 1 ( ( -LRB- cord-007714-n3omlvfl 68 2 Fig Fig NNP cord-007714-n3omlvfl 68 3 . . NNP cord-007714-n3omlvfl 68 4 1 1 CD cord-007714-n3omlvfl 68 5 ) ) -RRB- cord-007714-n3omlvfl 68 6 . . . cord-007714-n3omlvfl 69 1 The the DT cord-007714-n3omlvfl 69 2 DFC DFC NNP cord-007714-n3omlvfl 69 3 regions region NNS cord-007714-n3omlvfl 69 4 contain contain VBP cord-007714-n3omlvfl 69 5 rDNA rdna JJ cord-007714-n3omlvfl 69 6 transcription transcription NN cord-007714-n3omlvfl 69 7 units unit NNS cord-007714-n3omlvfl 69 8 which which WDT cord-007714-n3omlvfl 69 9 are be VBP cord-007714-n3omlvfl 69 10 being be VBG cord-007714-n3omlvfl 69 11 actively actively RB cord-007714-n3omlvfl 69 12 transcribed transcribe VBN cord-007714-n3omlvfl 69 13 and and CC cord-007714-n3omlvfl 69 14 have have VBP cord-007714-n3omlvfl 69 15 been be VBN cord-007714-n3omlvfl 69 16 visualised visualise VBN cord-007714-n3omlvfl 69 17 as as IN cord-007714-n3omlvfl 69 18 ' ' `` cord-007714-n3omlvfl 69 19 Christmas Christmas NNP cord-007714-n3omlvfl 69 20 tree tree NN cord-007714-n3omlvfl 69 21 ' ' '' cord-007714-n3omlvfl 69 22 structures structure NNS cord-007714-n3omlvfl 69 23 around around IN cord-007714-n3omlvfl 69 24 300 300 CD cord-007714-n3omlvfl 69 25 nm nm NN cord-007714-n3omlvfl 69 26 in in IN cord-007714-n3omlvfl 69 27 length length NN cord-007714-n3omlvfl 69 28 ( ( -LRB- cord-007714-n3omlvfl 69 29 Shaw Shaw NNP cord-007714-n3omlvfl 69 30 and and CC cord-007714-n3omlvfl 69 31 Jordan Jordan NNP cord-007714-n3omlvfl 69 32 1995 1995 CD cord-007714-n3omlvfl 69 33 ; ; : cord-007714-n3omlvfl 69 34 Gonzalez Gonzalez NNP cord-007714-n3omlvfl 69 35 - - HYPH cord-007714-n3omlvfl 69 36 Melendi Melendi NNP cord-007714-n3omlvfl 69 37 and and CC cord-007714-n3omlvfl 69 38 Shaw Shaw NNP cord-007714-n3omlvfl 69 39 2001 2001 CD cord-007714-n3omlvfl 69 40 ) ) -RRB- cord-007714-n3omlvfl 69 41 . . . cord-007714-n3omlvfl 70 1 The the DT cord-007714-n3omlvfl 70 2 localisation localisation NN cord-007714-n3omlvfl 70 3 by by IN cord-007714-n3omlvfl 70 4 fluorescence fluorescence NN cord-007714-n3omlvfl 70 5 microscopy microscopy NNS cord-007714-n3omlvfl 70 6 and and CC cord-007714-n3omlvfl 70 7 in in IN cord-007714-n3omlvfl 70 8 situ situ JJ cord-007714-n3omlvfl 70 9 hybridisation hybridisation NN cord-007714-n3omlvfl 70 10 of of IN cord-007714-n3omlvfl 70 11 nucleolar nucleolar JJ cord-007714-n3omlvfl 70 12 proteins protein NNS cord-007714-n3omlvfl 70 13 , , , cord-007714-n3omlvfl 70 14 rRNA rrna NN cord-007714-n3omlvfl 70 15 gene gene NN cord-007714-n3omlvfl 70 16 regions region NNS cord-007714-n3omlvfl 70 17 and and CC cord-007714-n3omlvfl 70 18 snoRNA snoRNA NNP cord-007714-n3omlvfl 70 19 species specie NNS cord-007714-n3omlvfl 70 20 to to IN cord-007714-n3omlvfl 70 21 sub sub NN cord-007714-n3omlvfl 70 22 - - NNS cord-007714-n3omlvfl 70 23 domains domain NNS cord-007714-n3omlvfl 70 24 within within IN cord-007714-n3omlvfl 70 25 plant plant NN cord-007714-n3omlvfl 70 26 nucleoli nucleolus NNS cord-007714-n3omlvfl 70 27 have have VBP cord-007714-n3omlvfl 70 28 been be VBN cord-007714-n3omlvfl 70 29 correlated correlate VBN cord-007714-n3omlvfl 70 30 with with IN cord-007714-n3omlvfl 70 31 early early JJ cord-007714-n3omlvfl 70 32 and and CC cord-007714-n3omlvfl 70 33 late late JJ cord-007714-n3omlvfl 70 34 events event NNS cord-007714-n3omlvfl 70 35 in in IN cord-007714-n3omlvfl 70 36 rRNA rrna NN cord-007714-n3omlvfl 70 37 processing processing NN cord-007714-n3omlvfl 70 38 ( ( -LRB- cord-007714-n3omlvfl 70 39 Beven Beven NNP cord-007714-n3omlvfl 70 40 et et NNP cord-007714-n3omlvfl 70 41 al al NNP cord-007714-n3omlvfl 70 42 . . . cord-007714-n3omlvfl 70 43 1996 1996 CD cord-007714-n3omlvfl 70 44 ; ; : cord-007714-n3omlvfl 70 45 Brown Brown NNP cord-007714-n3omlvfl 70 46 and and CC cord-007714-n3omlvfl 70 47 Shaw Shaw NNP cord-007714-n3omlvfl 70 48 1998 1998 CD cord-007714-n3omlvfl 70 49 ) ) -RRB- cord-007714-n3omlvfl 70 50 . . . cord-007714-n3omlvfl 71 1 A a DT cord-007714-n3omlvfl 71 2 distinctive distinctive JJ cord-007714-n3omlvfl 71 3 feature feature NN cord-007714-n3omlvfl 71 4 of of IN cord-007714-n3omlvfl 71 5 most most JJS cord-007714-n3omlvfl 71 6 plant plant NN cord-007714-n3omlvfl 71 7 nucleoli nucleoli NNP cord-007714-n3omlvfl 71 8 is be VBZ cord-007714-n3omlvfl 71 9 the the DT cord-007714-n3omlvfl 71 10 nucleolar nucleolar JJ cord-007714-n3omlvfl 71 11 cavity cavity NN cord-007714-n3omlvfl 71 12 , , , cord-007714-n3omlvfl 71 13 whose whose WP$ cord-007714-n3omlvfl 71 14 function function NN cord-007714-n3omlvfl 71 15 is be VBZ cord-007714-n3omlvfl 71 16 unknown unknown JJ cord-007714-n3omlvfl 71 17 but but CC cord-007714-n3omlvfl 71 18 contains contain VBZ cord-007714-n3omlvfl 71 19 spliceosomal spliceosomal JJ cord-007714-n3omlvfl 71 20 snRNAs snRNAs NNP cord-007714-n3omlvfl 71 21 and and CC cord-007714-n3omlvfl 71 22 accumulates accumulate VBZ cord-007714-n3omlvfl 71 23 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 72 1 ( ( -LRB- cord-007714-n3omlvfl 72 2 Beven Beven NNP cord-007714-n3omlvfl 72 3 et et NNP cord-007714-n3omlvfl 72 4 al al NNP cord-007714-n3omlvfl 72 5 . . . cord-007714-n3omlvfl 73 1 1995 1995 CD cord-007714-n3omlvfl 74 1 ( ( -LRB- cord-007714-n3omlvfl 74 2 Beven Beven NNP cord-007714-n3omlvfl 74 3 et et NNP cord-007714-n3omlvfl 74 4 al al NNP cord-007714-n3omlvfl 74 5 . . NNP cord-007714-n3omlvfl 74 6 , , , cord-007714-n3omlvfl 75 1 1996 1996 CD cord-007714-n3omlvfl 75 2 and and CC cord-007714-n3omlvfl 75 3 contains contain VBZ cord-007714-n3omlvfl 75 4 centres centre NNS cord-007714-n3omlvfl 75 5 for for IN cord-007714-n3omlvfl 75 6 the the DT cord-007714-n3omlvfl 75 7 production production NN cord-007714-n3omlvfl 75 8 of of IN cord-007714-n3omlvfl 75 9 heterochromatic heterochromatic JJ cord-007714-n3omlvfl 75 10 small small JJ cord-007714-n3omlvfl 75 11 interfering interfere VBG cord-007714-n3omlvfl 75 12 RNAs rna NNS cord-007714-n3omlvfl 75 13 ( ( -LRB- cord-007714-n3omlvfl 75 14 siRNAs siRNAs NNP cord-007714-n3omlvfl 75 15 ) ) -RRB- cord-007714-n3omlvfl 75 16 . . . cord-007714-n3omlvfl 76 1 The the DT cord-007714-n3omlvfl 76 2 relationship relationship NN cord-007714-n3omlvfl 76 3 between between IN cord-007714-n3omlvfl 76 4 these these DT cord-007714-n3omlvfl 76 5 centres centre NNS cord-007714-n3omlvfl 76 6 and and CC cord-007714-n3omlvfl 76 7 CBs CBs NNP cord-007714-n3omlvfl 76 8 is be VBZ cord-007714-n3omlvfl 76 9 not not RB cord-007714-n3omlvfl 76 10 yet yet RB cord-007714-n3omlvfl 76 11 clear clear JJ cord-007714-n3omlvfl 76 12 Pontes Pontes NNPS cord-007714-n3omlvfl 76 13 et et NNP cord-007714-n3omlvfl 76 14 al al NNP cord-007714-n3omlvfl 76 15 . . . cord-007714-n3omlvfl 76 16 2006 2006 CD cord-007714-n3omlvfl 76 17 ) ) -RRB- cord-007714-n3omlvfl 76 18 but but CC cord-007714-n3omlvfl 76 19 highlights highlight VBZ cord-007714-n3omlvfl 76 20 the the DT cord-007714-n3omlvfl 76 21 interaction interaction NN cord-007714-n3omlvfl 76 22 between between IN cord-007714-n3omlvfl 76 23 CBs CBs NNP cord-007714-n3omlvfl 76 24 and and CC cord-007714-n3omlvfl 76 25 the the DT cord-007714-n3omlvfl 76 26 nucleolus nucleolus NN cord-007714-n3omlvfl 76 27 . . . cord-007714-n3omlvfl 77 1 Plant Plant NNP cord-007714-n3omlvfl 77 2 CBs CBs NNP cord-007714-n3omlvfl 77 3 vary vary VBP cord-007714-n3omlvfl 77 4 in in IN cord-007714-n3omlvfl 77 5 number number NN cord-007714-n3omlvfl 77 6 and and CC cord-007714-n3omlvfl 77 7 size size NN cord-007714-n3omlvfl 77 8 in in IN cord-007714-n3omlvfl 77 9 different different JJ cord-007714-n3omlvfl 77 10 cells cell NNS cord-007714-n3omlvfl 77 11 and and CC cord-007714-n3omlvfl 77 12 under under IN cord-007714-n3omlvfl 77 13 different different JJ cord-007714-n3omlvfl 77 14 conditions condition NNS cord-007714-n3omlvfl 78 1 ( ( -LRB- cord-007714-n3omlvfl 78 2 Boudonck Boudonck NNP cord-007714-n3omlvfl 78 3 et et FW cord-007714-n3omlvfl 78 4 al al NNP cord-007714-n3omlvfl 78 5 . . . cord-007714-n3omlvfl 79 1 1998 1998 CD cord-007714-n3omlvfl 79 2 ; ; : cord-007714-n3omlvfl 79 3 Collier Collier NNP cord-007714-n3omlvfl 79 4 et et NNP cord-007714-n3omlvfl 79 5 al al NNP cord-007714-n3omlvfl 79 6 . . . cord-007714-n3omlvfl 79 7 2006 2006 CD cord-007714-n3omlvfl 79 8 ) ) -RRB- cord-007714-n3omlvfl 79 9 . . . cord-007714-n3omlvfl 80 1 Recently recently RB cord-007714-n3omlvfl 80 2 , , , cord-007714-n3omlvfl 80 3 plant plant NN cord-007714-n3omlvfl 80 4 coilin coilin NN cord-007714-n3omlvfl 80 5 was be VBD cord-007714-n3omlvfl 80 6 identified identify VBN cord-007714-n3omlvfl 80 7 and and CC cord-007714-n3omlvfl 80 8 , , , cord-007714-n3omlvfl 80 9 despite despite IN cord-007714-n3omlvfl 80 10 the the DT cord-007714-n3omlvfl 80 11 sequence sequence NN cord-007714-n3omlvfl 80 12 divergence divergence NN cord-007714-n3omlvfl 80 13 from from IN cord-007714-n3omlvfl 80 14 animal animal NN cord-007714-n3omlvfl 80 15 coilin coilin NN cord-007714-n3omlvfl 80 16 , , , cord-007714-n3omlvfl 80 17 was be VBD cord-007714-n3omlvfl 80 18 shown show VBN cord-007714-n3omlvfl 80 19 to to TO cord-007714-n3omlvfl 80 20 be be VB cord-007714-n3omlvfl 80 21 required require VBN cord-007714-n3omlvfl 80 22 for for IN cord-007714-n3omlvfl 80 23 CB CB NNP cord-007714-n3omlvfl 80 24 formation formation NN cord-007714-n3omlvfl 80 25 . . . cord-007714-n3omlvfl 81 1 Mutants mutant NNS cord-007714-n3omlvfl 81 2 in in IN cord-007714-n3omlvfl 81 3 plant plant NN cord-007714-n3omlvfl 81 4 coilin coilin NN cord-007714-n3omlvfl 81 5 will will MD cord-007714-n3omlvfl 81 6 be be VB cord-007714-n3omlvfl 81 7 invaluable invaluable JJ cord-007714-n3omlvfl 81 8 in in IN cord-007714-n3omlvfl 81 9 addressing address VBG cord-007714-n3omlvfl 81 10 the the DT cord-007714-n3omlvfl 81 11 functions function NNS cord-007714-n3omlvfl 81 12 and and CC cord-007714-n3omlvfl 81 13 properties property NNS cord-007714-n3omlvfl 81 14 of of IN cord-007714-n3omlvfl 81 15 plant plant NN cord-007714-n3omlvfl 81 16 CBs CBs NNP cord-007714-n3omlvfl 81 17 ( ( -LRB- cord-007714-n3omlvfl 81 18 Collier Collier NNP cord-007714-n3omlvfl 81 19 et et NNP cord-007714-n3omlvfl 81 20 al al NNP cord-007714-n3omlvfl 81 21 . . . cord-007714-n3omlvfl 81 22 2006 2006 CD cord-007714-n3omlvfl 81 23 ) ) -RRB- cord-007714-n3omlvfl 81 24 . . . cord-007714-n3omlvfl 82 1 Plant Plant NNP cord-007714-n3omlvfl 82 2 CBs CBs NNP cord-007714-n3omlvfl 82 3 also also RB cord-007714-n3omlvfl 82 4 contain contain VBP cord-007714-n3omlvfl 82 5 snRNAs snRNAs NNP cord-007714-n3omlvfl 82 6 , , , cord-007714-n3omlvfl 82 7 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 82 8 and and CC cord-007714-n3omlvfl 82 9 fibrillarin fibrillarin NNP cord-007714-n3omlvfl 83 1 ( ( -LRB- cord-007714-n3omlvfl 83 2 Beven Beven NNP cord-007714-n3omlvfl 83 3 et et NNP cord-007714-n3omlvfl 83 4 al al NNP cord-007714-n3omlvfl 83 5 . . . cord-007714-n3omlvfl 84 1 1995 1995 CD cord-007714-n3omlvfl 85 1 ( ( -LRB- cord-007714-n3omlvfl 85 2 Beven Beven NNP cord-007714-n3omlvfl 85 3 et et NNP cord-007714-n3omlvfl 85 4 al al NNP cord-007714-n3omlvfl 85 5 . . NNP cord-007714-n3omlvfl 85 6 , , , cord-007714-n3omlvfl 86 1 1996 1996 CD cord-007714-n3omlvfl 86 2 Brown Brown NNP cord-007714-n3omlvfl 86 3 and and CC cord-007714-n3omlvfl 86 4 Shaw Shaw NNP cord-007714-n3omlvfl 86 5 1998 1998 CD cord-007714-n3omlvfl 86 6 ) ) -RRB- cord-007714-n3omlvfl 86 7 and and CC cord-007714-n3omlvfl 86 8 plant plant NN cord-007714-n3omlvfl 86 9 scaRNAs scaRNAs NNPS cord-007714-n3omlvfl 86 10 have have VBP cord-007714-n3omlvfl 86 11 been be VBN cord-007714-n3omlvfl 86 12 identified identify VBN cord-007714-n3omlvfl 86 13 consistent consistent JJ cord-007714-n3omlvfl 86 14 with with IN cord-007714-n3omlvfl 86 15 conserved conserve VBN cord-007714-n3omlvfl 86 16 roles role NNS cord-007714-n3omlvfl 86 17 in in IN cord-007714-n3omlvfl 86 18 snRNP snrnp NN cord-007714-n3omlvfl 86 19 and and CC cord-007714-n3omlvfl 86 20 snoRNP snornp NN cord-007714-n3omlvfl 86 21 maturation maturation NN cord-007714-n3omlvfl 86 22 ( ( -LRB- cord-007714-n3omlvfl 86 23 Marker Marker NNP cord-007714-n3omlvfl 86 24 et et NNP cord-007714-n3omlvfl 86 25 al al NNP cord-007714-n3omlvfl 86 26 . . . cord-007714-n3omlvfl 86 27 2002 2002 CD cord-007714-n3omlvfl 86 28 ) ) -RRB- cord-007714-n3omlvfl 86 29 . . . cord-007714-n3omlvfl 87 1 Moreover moreover RB cord-007714-n3omlvfl 87 2 , , , cord-007714-n3omlvfl 87 3 the the DT cord-007714-n3omlvfl 87 4 majority majority NN cord-007714-n3omlvfl 87 5 of of IN cord-007714-n3omlvfl 87 6 plant plant NN cord-007714-n3omlvfl 87 7 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 87 8 are be VBP cord-007714-n3omlvfl 87 9 organised organise VBN cord-007714-n3omlvfl 87 10 in in IN cord-007714-n3omlvfl 87 11 gene gene NN cord-007714-n3omlvfl 87 12 clusters cluster NNS cord-007714-n3omlvfl 87 13 and and CC cord-007714-n3omlvfl 87 14 expressed express VBD cord-007714-n3omlvfl 87 15 as as IN cord-007714-n3omlvfl 87 16 polycistronic polycistronic JJ cord-007714-n3omlvfl 87 17 precursor precursor NN cord-007714-n3omlvfl 87 18 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 88 1 ( ( -LRB- cord-007714-n3omlvfl 88 2 Brown Brown NNP cord-007714-n3omlvfl 88 3 et et NNP cord-007714-n3omlvfl 88 4 al al NNP cord-007714-n3omlvfl 88 5 . . NNP cord-007714-n3omlvfl 88 6 2003 2003 CD cord-007714-n3omlvfl 88 7 ) ) -RRB- cord-007714-n3omlvfl 88 8 . . . cord-007714-n3omlvfl 89 1 The the DT cord-007714-n3omlvfl 89 2 detection detection NN cord-007714-n3omlvfl 89 3 of of IN cord-007714-n3omlvfl 89 4 these these DT cord-007714-n3omlvfl 89 5 polycistronic polycistronic JJ cord-007714-n3omlvfl 89 6 precursors precursor NNS cord-007714-n3omlvfl 89 7 in in IN cord-007714-n3omlvfl 89 8 CBs CBs NNP cord-007714-n3omlvfl 89 9 and and CC cord-007714-n3omlvfl 89 10 the the DT cord-007714-n3omlvfl 89 11 nucleolus nucleolus NN cord-007714-n3omlvfl 89 12 by by IN cord-007714-n3omlvfl 89 13 in in IN cord-007714-n3omlvfl 89 14 situ situ NN cord-007714-n3omlvfl 89 15 hybridisation hybridisation NN cord-007714-n3omlvfl 89 16 suggests suggest VBZ cord-007714-n3omlvfl 89 17 that that IN cord-007714-n3omlvfl 89 18 processing processing NN cord-007714-n3omlvfl 89 19 occurs occur VBZ cord-007714-n3omlvfl 89 20 in in IN cord-007714-n3omlvfl 89 21 both both DT cord-007714-n3omlvfl 89 22 locations location NNS cord-007714-n3omlvfl 89 23 and/or and/or CC cord-007714-n3omlvfl 89 24 that that DT cord-007714-n3omlvfl 89 25 pre pre JJ cord-007714-n3omlvfl 89 26 - - VB cord-007714-n3omlvfl 89 27 snoRNAs snornas JJ cord-007714-n3omlvfl 89 28 traffic traffic NN cord-007714-n3omlvfl 89 29 to to IN cord-007714-n3omlvfl 89 30 the the DT cord-007714-n3omlvfl 89 31 nucleolus nucleolus NN cord-007714-n3omlvfl 89 32 via via IN cord-007714-n3omlvfl 89 33 CBs CBs NNP cord-007714-n3omlvfl 89 34 ) ) -RRB- cord-007714-n3omlvfl 89 35 . . . cord-007714-n3omlvfl 90 1 The the DT cord-007714-n3omlvfl 90 2 nucleolus nucleolus NN cord-007714-n3omlvfl 90 3 is be VBZ cord-007714-n3omlvfl 90 4 also also RB cord-007714-n3omlvfl 90 5 involved involve VBN cord-007714-n3omlvfl 90 6 in in IN cord-007714-n3omlvfl 90 7 some some DT cord-007714-n3omlvfl 90 8 virus virus NN cord-007714-n3omlvfl 90 9 infections infection NNS cord-007714-n3omlvfl 90 10 ( ( -LRB- cord-007714-n3omlvfl 90 11 both both DT cord-007714-n3omlvfl 90 12 animal animal NN cord-007714-n3omlvfl 90 13 and and CC cord-007714-n3omlvfl 90 14 plant plant NN cord-007714-n3omlvfl 90 15 ) ) -RRB- cord-007714-n3omlvfl 90 16 , , , cord-007714-n3omlvfl 90 17 with with IN cord-007714-n3omlvfl 90 18 particular particular JJ cord-007714-n3omlvfl 90 19 viral viral JJ cord-007714-n3omlvfl 90 20 proteins protein NNS cord-007714-n3omlvfl 90 21 localising localise VBG cord-007714-n3omlvfl 90 22 to to IN cord-007714-n3omlvfl 90 23 the the DT cord-007714-n3omlvfl 90 24 nucleolus nucleolus NN cord-007714-n3omlvfl 91 1 ( ( -LRB- cord-007714-n3omlvfl 91 2 Hiscox Hiscox NNP cord-007714-n3omlvfl 91 3 2002 2002 CD cord-007714-n3omlvfl 91 4 ( ( -LRB- cord-007714-n3omlvfl 91 5 Hiscox Hiscox NNP cord-007714-n3omlvfl 91 6 , , , cord-007714-n3omlvfl 91 7 2007 2007 CD cord-007714-n3omlvfl 91 8 . . . cord-007714-n3omlvfl 92 1 Although although IN cord-007714-n3omlvfl 92 2 the the DT cord-007714-n3omlvfl 92 3 function function NN cord-007714-n3omlvfl 92 4 of of IN cord-007714-n3omlvfl 92 5 the the DT cord-007714-n3omlvfl 92 6 nucleolar nucleolar JJ cord-007714-n3omlvfl 92 7 localisation localisation NN cord-007714-n3omlvfl 92 8 of of IN cord-007714-n3omlvfl 92 9 many many JJ cord-007714-n3omlvfl 92 10 of of IN cord-007714-n3omlvfl 92 11 these these DT cord-007714-n3omlvfl 92 12 proteins protein NNS cord-007714-n3omlvfl 92 13 remains remain VBZ cord-007714-n3omlvfl 92 14 to to TO cord-007714-n3omlvfl 92 15 be be VB cord-007714-n3omlvfl 92 16 established establish VBN cord-007714-n3omlvfl 92 17 , , , cord-007714-n3omlvfl 92 18 the the DT cord-007714-n3omlvfl 92 19 nucleolar nucleolar JJ cord-007714-n3omlvfl 92 20 accumulation accumulation NN cord-007714-n3omlvfl 92 21 of of IN cord-007714-n3omlvfl 92 22 the the DT cord-007714-n3omlvfl 92 23 ORF3 ORF3 NNP cord-007714-n3omlvfl 92 24 protein protein NN cord-007714-n3omlvfl 92 25 of of IN cord-007714-n3omlvfl 92 26 the the DT cord-007714-n3omlvfl 92 27 plant plant NN cord-007714-n3omlvfl 92 28 virus virus NN cord-007714-n3omlvfl 92 29 groundnut groundnut NN cord-007714-n3omlvfl 92 30 rosette rosette NN cord-007714-n3omlvfl 92 31 virus virus NN cord-007714-n3omlvfl 92 32 ( ( -LRB- cord-007714-n3omlvfl 92 33 GRV GRV NNP cord-007714-n3omlvfl 92 34 ) ) -RRB- cord-007714-n3omlvfl 92 35 has have VBZ cord-007714-n3omlvfl 92 36 been be VBN cord-007714-n3omlvfl 92 37 shown show VBN cord-007714-n3omlvfl 92 38 to to TO cord-007714-n3omlvfl 92 39 involve involve VB cord-007714-n3omlvfl 92 40 interactions interaction NNS cord-007714-n3omlvfl 92 41 with with IN cord-007714-n3omlvfl 92 42 CBs CBs NNP cord-007714-n3omlvfl 92 43 and and CC cord-007714-n3omlvfl 92 44 fibrillarin fibrillarin NNP cord-007714-n3omlvfl 92 45 and and CC cord-007714-n3omlvfl 92 46 is be VBZ cord-007714-n3omlvfl 92 47 essential essential JJ cord-007714-n3omlvfl 92 48 for for IN cord-007714-n3omlvfl 92 49 the the DT cord-007714-n3omlvfl 92 50 formation formation NN cord-007714-n3omlvfl 92 51 of of IN cord-007714-n3omlvfl 92 52 cytoplasmic cytoplasmic JJ cord-007714-n3omlvfl 92 53 RNPs rnp NNS cord-007714-n3omlvfl 92 54 and and CC cord-007714-n3omlvfl 92 55 long long JJ cord-007714-n3omlvfl 92 56 - - HYPH cord-007714-n3omlvfl 92 57 distance distance NN cord-007714-n3omlvfl 92 58 virus virus NN cord-007714-n3omlvfl 92 59 movement movement NN cord-007714-n3omlvfl 93 1 ( ( -LRB- cord-007714-n3omlvfl 93 2 Kim Kim NNP cord-007714-n3omlvfl 93 3 et et NNP cord-007714-n3omlvfl 93 4 al al NNP cord-007714-n3omlvfl 93 5 . . . cord-007714-n3omlvfl 94 1 2007a 2007a CD cord-007714-n3omlvfl 94 2 , , , cord-007714-n3omlvfl 94 3 b b LS cord-007714-n3omlvfl 94 4 ) ) -RRB- cord-007714-n3omlvfl 94 5 . . . cord-007714-n3omlvfl 95 1 Finally finally RB cord-007714-n3omlvfl 95 2 , , , cord-007714-n3omlvfl 95 3 the the DT cord-007714-n3omlvfl 95 4 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 95 5 nucleolus nucleolus NN cord-007714-n3omlvfl 95 6 contains contain VBZ cord-007714-n3omlvfl 95 7 exon exon NN cord-007714-n3omlvfl 95 8 junction junction NN cord-007714-n3omlvfl 95 9 complex complex JJ cord-007714-n3omlvfl 95 10 proteins protein NNS cord-007714-n3omlvfl 95 11 , , , cord-007714-n3omlvfl 95 12 involved involve VBN cord-007714-n3omlvfl 95 13 in in IN cord-007714-n3omlvfl 95 14 linking link VBG cord-007714-n3omlvfl 95 15 transcription transcription NN cord-007714-n3omlvfl 95 16 and and CC cord-007714-n3omlvfl 95 17 splicing splicing NN cord-007714-n3omlvfl 95 18 to to IN cord-007714-n3omlvfl 95 19 translation translation NN cord-007714-n3omlvfl 95 20 , , , cord-007714-n3omlvfl 95 21 export export NN cord-007714-n3omlvfl 95 22 and and CC cord-007714-n3omlvfl 95 23 mRNA mrna NN cord-007714-n3omlvfl 95 24 surveillance surveillance NN cord-007714-n3omlvfl 95 25 ( ( -LRB- cord-007714-n3omlvfl 95 26 Pendle Pendle NNP cord-007714-n3omlvfl 95 27 et et NNP cord-007714-n3omlvfl 95 28 al al NNP cord-007714-n3omlvfl 95 29 . . NNP cord-007714-n3omlvfl 95 30 2005 2005 CD cord-007714-n3omlvfl 95 31 ) ) -RRB- cord-007714-n3omlvfl 95 32 . . . cord-007714-n3omlvfl 96 1 Thus thus RB cord-007714-n3omlvfl 96 2 new new JJ cord-007714-n3omlvfl 96 3 functions function NNS cord-007714-n3omlvfl 96 4 in in IN cord-007714-n3omlvfl 96 5 RNA RNA NNP cord-007714-n3omlvfl 96 6 metabolism metabolism NN cord-007714-n3omlvfl 96 7 have have VBP cord-007714-n3omlvfl 96 8 been be VBN cord-007714-n3omlvfl 96 9 demonstrated demonstrate VBN cord-007714-n3omlvfl 96 10 for for IN cord-007714-n3omlvfl 96 11 both both DT cord-007714-n3omlvfl 96 12 plant plant NN cord-007714-n3omlvfl 96 13 CBs CBs NNP cord-007714-n3omlvfl 96 14 and and CC cord-007714-n3omlvfl 96 15 the the DT cord-007714-n3omlvfl 96 16 nucleolus nucleolus NN cord-007714-n3omlvfl 96 17 . . . cord-007714-n3omlvfl 97 1 Other other JJ cord-007714-n3omlvfl 97 2 nuclear nuclear JJ cord-007714-n3omlvfl 97 3 bodies body NNS cord-007714-n3omlvfl 97 4 in in IN cord-007714-n3omlvfl 97 5 plants plant NNS cord-007714-n3omlvfl 97 6 have have VBP cord-007714-n3omlvfl 97 7 been be VBN cord-007714-n3omlvfl 97 8 defined define VBN cord-007714-n3omlvfl 97 9 by by IN cord-007714-n3omlvfl 97 10 the the DT cord-007714-n3omlvfl 97 11 presence presence NN cord-007714-n3omlvfl 97 12 of of IN cord-007714-n3omlvfl 97 13 particular particular JJ cord-007714-n3omlvfl 97 14 proteins protein NNS cord-007714-n3omlvfl 97 15 such such JJ cord-007714-n3omlvfl 97 16 as as IN cord-007714-n3omlvfl 97 17 splicing splicing NN cord-007714-n3omlvfl 97 18 factors factor NNS cord-007714-n3omlvfl 97 19 ( ( -LRB- cord-007714-n3omlvfl 97 20 see see VB cord-007714-n3omlvfl 97 21 the the DT cord-007714-n3omlvfl 97 22 chapter chapter NN cord-007714-n3omlvfl 97 23 by by IN cord-007714-n3omlvfl 97 24 G. G. NNP cord-007714-n3omlvfl 97 25 S. S. NNP cord-007714-n3omlvfl 97 26 Ali Ali NNP cord-007714-n3omlvfl 97 27 and and CC cord-007714-n3omlvfl 97 28 A. A. NNP cord-007714-n3omlvfl 97 29 S. S. NNP cord-007714-n3omlvfl 97 30 N. N. NNP cord-007714-n3omlvfl 97 31 Reddy Reddy NNP cord-007714-n3omlvfl 97 32 , , , cord-007714-n3omlvfl 97 33 this this DT cord-007714-n3omlvfl 97 34 volume volume NN cord-007714-n3omlvfl 97 35 ) ) -RRB- cord-007714-n3omlvfl 97 36 and and CC cord-007714-n3omlvfl 97 37 cyclophilins cyclophilin NNS cord-007714-n3omlvfl 97 38 , , , cord-007714-n3omlvfl 97 39 HYL1 HYL1 NNP cord-007714-n3omlvfl 97 40 , , , cord-007714-n3omlvfl 97 41 phytochrome phytochrome NN cord-007714-n3omlvfl 97 42 and and CC cord-007714-n3omlvfl 97 43 AKIP1 akip1 NN cord-007714-n3omlvfl 97 44 . . . cord-007714-n3omlvfl 98 1 At at IN cord-007714-n3omlvfl 98 2 present present NN cord-007714-n3omlvfl 98 3 , , , cord-007714-n3omlvfl 98 4 the the DT cord-007714-n3omlvfl 98 5 components component NNS cord-007714-n3omlvfl 98 6 and and CC cord-007714-n3omlvfl 98 7 functions function NNS cord-007714-n3omlvfl 98 8 of of IN cord-007714-n3omlvfl 98 9 these these DT cord-007714-n3omlvfl 98 10 bodies body NNS cord-007714-n3omlvfl 98 11 are be VBP cord-007714-n3omlvfl 98 12 not not RB cord-007714-n3omlvfl 98 13 well well RB cord-007714-n3omlvfl 98 14 characterised characterise VBN cord-007714-n3omlvfl 98 15 but but CC cord-007714-n3omlvfl 98 16 SR SR NNP cord-007714-n3omlvfl 98 17 proteins protein NNS cord-007714-n3omlvfl 98 18 and and CC cord-007714-n3omlvfl 98 19 cyclophilins cyclophilin NNS cord-007714-n3omlvfl 98 20 are be VBP cord-007714-n3omlvfl 98 21 found find VBN cord-007714-n3omlvfl 98 22 in in IN cord-007714-n3omlvfl 98 23 distinct distinct JJ cord-007714-n3omlvfl 98 24 splicing splicing NN cord-007714-n3omlvfl 98 25 speckles speckle NNS cord-007714-n3omlvfl 98 26 and and CC cord-007714-n3omlvfl 98 27 cyclophilin cyclophilin NN cord-007714-n3omlvfl 98 28 - - HYPH cord-007714-n3omlvfl 98 29 containing contain VBG cord-007714-n3omlvfl 98 30 bodies body NNS cord-007714-n3omlvfl 98 31 can can MD cord-007714-n3omlvfl 98 32 interact interact VB cord-007714-n3omlvfl 98 33 and and CC cord-007714-n3omlvfl 98 34 regulate regulate VB cord-007714-n3omlvfl 98 35 functions function NNS cord-007714-n3omlvfl 98 36 in in IN cord-007714-n3omlvfl 98 37 splicing splicing NN cord-007714-n3omlvfl 98 38 ( ( -LRB- cord-007714-n3omlvfl 98 39 Lorković Lorković NNP cord-007714-n3omlvfl 98 40 2004 2004 CD cord-007714-n3omlvfl 98 41 ) ) -RRB- cord-007714-n3omlvfl 98 42 . . . cord-007714-n3omlvfl 99 1 HYL1 HYL1 NNP cord-007714-n3omlvfl 99 2 , , , cord-007714-n3omlvfl 99 3 involved involve VBN cord-007714-n3omlvfl 99 4 in in IN cord-007714-n3omlvfl 99 5 microRNA microRNA NNP cord-007714-n3omlvfl 99 6 biogenesis biogenesis NN cord-007714-n3omlvfl 99 7 , , , cord-007714-n3omlvfl 99 8 localises localise VBZ cord-007714-n3omlvfl 99 9 to to IN cord-007714-n3omlvfl 99 10 a a DT cord-007714-n3omlvfl 99 11 small small JJ cord-007714-n3omlvfl 99 12 number number NN cord-007714-n3omlvfl 99 13 of of IN cord-007714-n3omlvfl 99 14 nuclear nuclear JJ cord-007714-n3omlvfl 99 15 bodies body NNS cord-007714-n3omlvfl 99 16 while while IN cord-007714-n3omlvfl 99 17 phytochrome phytochrome NN cord-007714-n3omlvfl 99 18 - - : cord-007714-n3omlvfl 99 19 and and CC cord-007714-n3omlvfl 99 20 AKIP AKIP NNP cord-007714-n3omlvfl 99 21 - - HYPH cord-007714-n3omlvfl 99 22 containing contain VBG cord-007714-n3omlvfl 99 23 bodies body NNS cord-007714-n3omlvfl 99 24 are be VBP cord-007714-n3omlvfl 99 25 involved involve VBN cord-007714-n3omlvfl 99 26 in in IN cord-007714-n3omlvfl 99 27 signalling signal VBG cord-007714-n3omlvfl 99 28 pathways pathway NNS cord-007714-n3omlvfl 99 29 interactions interaction NNS cord-007714-n3omlvfl 99 30 and and CC cord-007714-n3omlvfl 99 31 may may MD cord-007714-n3omlvfl 99 32 regulate regulate VB cord-007714-n3omlvfl 99 33 mRNAs mrna NNS cord-007714-n3omlvfl 99 34 at at IN cord-007714-n3omlvfl 99 35 the the DT cord-007714-n3omlvfl 99 36 transcriptional transcriptional JJ cord-007714-n3omlvfl 99 37 or or CC cord-007714-n3omlvfl 99 38 post post JJ cord-007714-n3omlvfl 99 39 - - JJ cord-007714-n3omlvfl 99 40 transcriptional transcriptional JJ cord-007714-n3omlvfl 99 41 levels level NNS cord-007714-n3omlvfl 99 42 ( ( -LRB- cord-007714-n3omlvfl 99 43 Yamaguchi Yamaguchi NNP cord-007714-n3omlvfl 99 44 et et NNP cord-007714-n3omlvfl 99 45 al al NNP cord-007714-n3omlvfl 99 46 . . . cord-007714-n3omlvfl 99 47 1999 1999 CD cord-007714-n3omlvfl 99 48 ; ; : cord-007714-n3omlvfl 99 49 Han Han NNP cord-007714-n3omlvfl 99 50 et et NNP cord-007714-n3omlvfl 99 51 al al NNP cord-007714-n3omlvfl 99 52 . . . cord-007714-n3omlvfl 99 53 2002 2002 CD cord-007714-n3omlvfl 99 54 ; ; : cord-007714-n3omlvfl 99 55 Kircher Kircher NNP cord-007714-n3omlvfl 99 56 et et NNP cord-007714-n3omlvfl 99 57 al al NNP cord-007714-n3omlvfl 99 58 . . . cord-007714-n3omlvfl 100 1 2002 2002 CD cord-007714-n3omlvfl 100 2 ; ; : cord-007714-n3omlvfl 100 3 Chen Chen NNP cord-007714-n3omlvfl 100 4 et et NNP cord-007714-n3omlvfl 100 5 al al NNP cord-007714-n3omlvfl 100 6 . . . cord-007714-n3omlvfl 101 1 2003 2003 CD cord-007714-n3omlvfl 101 2 ; ; : cord-007714-n3omlvfl 101 3 Ang Ang NNP cord-007714-n3omlvfl 101 4 et et NNP cord-007714-n3omlvfl 101 5 al al NNP cord-007714-n3omlvfl 101 6 . . NNP cord-007714-n3omlvfl 101 7 1998 1998 CD cord-007714-n3omlvfl 101 8 ; ; : cord-007714-n3omlvfl 101 9 Li Li NNP cord-007714-n3omlvfl 101 10 et et NNP cord-007714-n3omlvfl 101 11 al al NNP cord-007714-n3omlvfl 101 12 . . . cord-007714-n3omlvfl 102 1 2002 2002 CD cord-007714-n3omlvfl 102 2 ; ; : cord-007714-n3omlvfl 102 3 Shaw Shaw NNP cord-007714-n3omlvfl 102 4 and and CC cord-007714-n3omlvfl 102 5 Brown Brown NNP cord-007714-n3omlvfl 102 6 2004 2004 CD cord-007714-n3omlvfl 102 7 ; ; : cord-007714-n3omlvfl 102 8 Song Song NNP cord-007714-n3omlvfl 102 9 et et FW cord-007714-n3omlvfl 102 10 al al NNP cord-007714-n3omlvfl 102 11 . . NNP cord-007714-n3omlvfl 102 12 2007 2007 CD cord-007714-n3omlvfl 102 13 ) ) -RRB- cord-007714-n3omlvfl 102 14 . . . cord-007714-n3omlvfl 103 1 Thus thus RB cord-007714-n3omlvfl 103 2 nuclear nuclear JJ cord-007714-n3omlvfl 103 3 bodies body NNS cord-007714-n3omlvfl 103 4 are be VBP cord-007714-n3omlvfl 103 5 sites site NNS cord-007714-n3omlvfl 103 6 where where WRB cord-007714-n3omlvfl 103 7 different different JJ cord-007714-n3omlvfl 103 8 factors factor NNS cord-007714-n3omlvfl 103 9 accumulate accumulate VBP cord-007714-n3omlvfl 103 10 , , , cord-007714-n3omlvfl 103 11 allowing allow VBG cord-007714-n3omlvfl 103 12 efficient efficient JJ cord-007714-n3omlvfl 103 13 RNA RNA NNP cord-007714-n3omlvfl 103 14 - - HYPH cord-007714-n3omlvfl 103 15 protein protein NN cord-007714-n3omlvfl 103 16 and and CC cord-007714-n3omlvfl 103 17 protein protein NN cord-007714-n3omlvfl 103 18 - - HYPH cord-007714-n3omlvfl 103 19 protein protein NN cord-007714-n3omlvfl 103 20 interactions interaction NNS cord-007714-n3omlvfl 103 21 or or CC cord-007714-n3omlvfl 103 22 RNP RNP NNP cord-007714-n3omlvfl 103 23 assembly assembly NN cord-007714-n3omlvfl 103 24 , , , cord-007714-n3omlvfl 103 25 to to TO cord-007714-n3omlvfl 103 26 influence influence VB cord-007714-n3omlvfl 103 27 or or CC cord-007714-n3omlvfl 103 28 regulate regulate VB cord-007714-n3omlvfl 103 29 a a DT cord-007714-n3omlvfl 103 30 particular particular JJ cord-007714-n3omlvfl 103 31 process process NN cord-007714-n3omlvfl 103 32 . . . cord-007714-n3omlvfl 104 1 The the DT cord-007714-n3omlvfl 104 2 bodies body NNS cord-007714-n3omlvfl 104 3 can can MD cord-007714-n3omlvfl 104 4 form form VB cord-007714-n3omlvfl 104 5 or or CC cord-007714-n3omlvfl 104 6 dissemble dissemble VB cord-007714-n3omlvfl 104 7 or or CC cord-007714-n3omlvfl 104 8 increase increase VB cord-007714-n3omlvfl 104 9 and and CC cord-007714-n3omlvfl 104 10 decrease decrease VB cord-007714-n3omlvfl 104 11 in in IN cord-007714-n3omlvfl 104 12 size size NN cord-007714-n3omlvfl 104 13 and and CC cord-007714-n3omlvfl 104 14 number number NN cord-007714-n3omlvfl 104 15 depending depend VBG cord-007714-n3omlvfl 104 16 on on IN cord-007714-n3omlvfl 104 17 different different JJ cord-007714-n3omlvfl 104 18 conditions condition NNS cord-007714-n3omlvfl 104 19 or or CC cord-007714-n3omlvfl 104 20 activity activity NN cord-007714-n3omlvfl 104 21 of of IN cord-007714-n3omlvfl 104 22 the the DT cord-007714-n3omlvfl 104 23 cell cell NN cord-007714-n3omlvfl 104 24 , , , cord-007714-n3omlvfl 104 25 again again RB cord-007714-n3omlvfl 104 26 reflecting reflect VBG cord-007714-n3omlvfl 104 27 the the DT cord-007714-n3omlvfl 104 28 dynamic dynamic JJ cord-007714-n3omlvfl 104 29 interplay interplay NN cord-007714-n3omlvfl 104 30 between between IN cord-007714-n3omlvfl 104 31 nuclear nuclear JJ cord-007714-n3omlvfl 104 32 bodies body NNS cord-007714-n3omlvfl 104 33 and and CC cord-007714-n3omlvfl 104 34 the the DT cord-007714-n3omlvfl 104 35 surrounding surround VBG cord-007714-n3omlvfl 104 36 nucleoplasm nucleoplasm NN cord-007714-n3omlvfl 104 37 . . . cord-007714-n3omlvfl 105 1 The the DT cord-007714-n3omlvfl 105 2 major major JJ cord-007714-n3omlvfl 105 3 recognised recognise VBN cord-007714-n3omlvfl 105 4 function function NN cord-007714-n3omlvfl 105 5 of of IN cord-007714-n3omlvfl 105 6 the the DT cord-007714-n3omlvfl 105 7 nucleolus nucleolus NN cord-007714-n3omlvfl 105 8 is be VBZ cord-007714-n3omlvfl 105 9 transcription transcription NN cord-007714-n3omlvfl 105 10 and and CC cord-007714-n3omlvfl 105 11 processing processing NN cord-007714-n3omlvfl 105 12 of of IN cord-007714-n3omlvfl 105 13 ribosomal ribosomal JJ cord-007714-n3omlvfl 105 14 RNA RNA NNP cord-007714-n3omlvfl 105 15 and and CC cord-007714-n3omlvfl 105 16 assembly assembly NN cord-007714-n3omlvfl 105 17 of of IN cord-007714-n3omlvfl 105 18 ribosomal ribosomal JJ cord-007714-n3omlvfl 105 19 subunits subunit NNS cord-007714-n3omlvfl 105 20 . . . cord-007714-n3omlvfl 106 1 Eukaryotic eukaryotic JJ cord-007714-n3omlvfl 106 2 ribosomal ribosomal NN cord-007714-n3omlvfl 106 3 RNA RNA NNP cord-007714-n3omlvfl 106 4 genes gene NNS cord-007714-n3omlvfl 106 5 are be VBP cord-007714-n3omlvfl 106 6 organised organise VBN cord-007714-n3omlvfl 106 7 in in IN cord-007714-n3omlvfl 106 8 large large JJ cord-007714-n3omlvfl 106 9 clusters cluster NNS cord-007714-n3omlvfl 106 10 , , , cord-007714-n3omlvfl 106 11 often often RB cord-007714-n3omlvfl 106 12 containing contain VBG cord-007714-n3omlvfl 106 13 hundreds hundred NNS cord-007714-n3omlvfl 106 14 or or CC cord-007714-n3omlvfl 106 15 thousands thousand NNS cord-007714-n3omlvfl 106 16 of of IN cord-007714-n3omlvfl 106 17 repeated repeat VBN cord-007714-n3omlvfl 106 18 genes gene NNS cord-007714-n3omlvfl 106 19 , , , cord-007714-n3omlvfl 106 20 with with IN cord-007714-n3omlvfl 106 21 each each DT cord-007714-n3omlvfl 106 22 gene gene NN cord-007714-n3omlvfl 106 23 encoding encode VBG cord-007714-n3omlvfl 106 24 one one CD cord-007714-n3omlvfl 106 25 copy copy NN cord-007714-n3omlvfl 106 26 of of IN cord-007714-n3omlvfl 106 27 the the DT cord-007714-n3omlvfl 106 28 18S 18S NNPS cord-007714-n3omlvfl 106 29 , , , cord-007714-n3omlvfl 106 30 5.8S 5.8s NN cord-007714-n3omlvfl 106 31 and and CC cord-007714-n3omlvfl 106 32 25 25 CD cord-007714-n3omlvfl 106 33 - - HYPH cord-007714-n3omlvfl 106 34 28S 28S NNP cord-007714-n3omlvfl 106 35 rRNAs rRNAs NNPS cord-007714-n3omlvfl 106 36 . . . cord-007714-n3omlvfl 107 1 The the DT cord-007714-n3omlvfl 107 2 coding code VBG cord-007714-n3omlvfl 107 3 regions region NNS cord-007714-n3omlvfl 107 4 are be VBP cord-007714-n3omlvfl 107 5 separated separate VBN cord-007714-n3omlvfl 107 6 by by IN cord-007714-n3omlvfl 107 7 internal internal JJ cord-007714-n3omlvfl 107 8 transcribed transcribe VBN cord-007714-n3omlvfl 107 9 spacer spacer NN cord-007714-n3omlvfl 107 10 ( ( -LRB- cord-007714-n3omlvfl 107 11 ITS its PRP$ cord-007714-n3omlvfl 107 12 ) ) -RRB- cord-007714-n3omlvfl 107 13 regions region NNS cord-007714-n3omlvfl 107 14 and and CC cord-007714-n3omlvfl 107 15 flanked flank VBN cord-007714-n3omlvfl 107 16 by by IN cord-007714-n3omlvfl 107 17 external external JJ cord-007714-n3omlvfl 107 18 transcribed transcribe VBN cord-007714-n3omlvfl 107 19 spacer spacer NN cord-007714-n3omlvfl 107 20 ( ( -LRB- cord-007714-n3omlvfl 107 21 ETS ETS NNP cord-007714-n3omlvfl 107 22 ) ) -RRB- cord-007714-n3omlvfl 107 23 regions region NNS cord-007714-n3omlvfl 107 24 . . . cord-007714-n3omlvfl 108 1 Genes gene NNS cord-007714-n3omlvfl 108 2 are be VBP cord-007714-n3omlvfl 108 3 transcribed transcribe VBN cord-007714-n3omlvfl 108 4 by by IN cord-007714-n3omlvfl 108 5 RNA RNA NNP cord-007714-n3omlvfl 108 6 polymerase polymerase NN cord-007714-n3omlvfl 108 7 I -PRON- PRP cord-007714-n3omlvfl 108 8 as as IN cord-007714-n3omlvfl 108 9 polycistronic polycistronic JJ cord-007714-n3omlvfl 108 10 precursor precursor NN cord-007714-n3omlvfl 108 11 rRNAs rrna NNS cord-007714-n3omlvfl 108 12 which which WDT cord-007714-n3omlvfl 108 13 are be VBP cord-007714-n3omlvfl 108 14 processed process VBN cord-007714-n3omlvfl 108 15 to to IN cord-007714-n3omlvfl 108 16 the the DT cord-007714-n3omlvfl 108 17 mature mature JJ cord-007714-n3omlvfl 108 18 5.8S 5.8s NN cord-007714-n3omlvfl 108 19 , , , cord-007714-n3omlvfl 108 20 18S 18S NNPS cord-007714-n3omlvfl 108 21 and and CC cord-007714-n3omlvfl 108 22 25 25 CD cord-007714-n3omlvfl 108 23 - - HYPH cord-007714-n3omlvfl 108 24 28S 28S NNP cord-007714-n3omlvfl 109 1 rRNAs rRNAs NNPS cord-007714-n3omlvfl 109 2 . . . cord-007714-n3omlvfl 110 1 Processing processing NN cord-007714-n3omlvfl 110 2 of of IN cord-007714-n3omlvfl 110 3 pre pre JJ cord-007714-n3omlvfl 110 4 - - NNS cord-007714-n3omlvfl 110 5 rRNAs rrnas JJ cord-007714-n3omlvfl 110 6 involves involve VBZ cord-007714-n3omlvfl 110 7 ( ( -LRB- cord-007714-n3omlvfl 110 8 a a LS cord-007714-n3omlvfl 110 9 ) ) -RRB- cord-007714-n3omlvfl 110 10 cleavage cleavage NN cord-007714-n3omlvfl 110 11 of of IN cord-007714-n3omlvfl 110 12 the the DT cord-007714-n3omlvfl 110 13 transcript transcript NN cord-007714-n3omlvfl 110 14 into into IN cord-007714-n3omlvfl 110 15 precursors precursor NNS cord-007714-n3omlvfl 110 16 of of IN cord-007714-n3omlvfl 110 17 the the DT cord-007714-n3omlvfl 110 18 mature mature JJ cord-007714-n3omlvfl 110 19 rRNAs rrna NNS cord-007714-n3omlvfl 110 20 and and CC cord-007714-n3omlvfl 110 21 trimming trimming NN cord-007714-n3omlvfl 110 22 of of IN cord-007714-n3omlvfl 110 23 these these DT cord-007714-n3omlvfl 110 24 precursors precursor NNS cord-007714-n3omlvfl 110 25 to to IN cord-007714-n3omlvfl 110 26 their -PRON- PRP$ cord-007714-n3omlvfl 110 27 final final JJ cord-007714-n3omlvfl 110 28 size size NN cord-007714-n3omlvfl 110 29 and and CC cord-007714-n3omlvfl 110 30 ( ( -LRB- cord-007714-n3omlvfl 110 31 b b NN cord-007714-n3omlvfl 110 32 ) ) -RRB- cord-007714-n3omlvfl 110 33 modification modification NN cord-007714-n3omlvfl 110 34 of of IN cord-007714-n3omlvfl 110 35 specific specific JJ cord-007714-n3omlvfl 110 36 rRNA rRNA NNP cord-007714-n3omlvfl 110 37 nucleotides nucleotide NNS cord-007714-n3omlvfl 110 38 . . . cord-007714-n3omlvfl 111 1 The the DT cord-007714-n3omlvfl 111 2 best well RBS cord-007714-n3omlvfl 111 3 - - HYPH cord-007714-n3omlvfl 111 4 characterised characterise VBN cord-007714-n3omlvfl 111 5 pathway pathway NN cord-007714-n3omlvfl 111 6 of of IN cord-007714-n3omlvfl 111 7 pre pre JJ cord-007714-n3omlvfl 111 8 - - JJ cord-007714-n3omlvfl 111 9 rRNA rrna JJ cord-007714-n3omlvfl 111 10 processing processing NN cord-007714-n3omlvfl 111 11 is be VBZ cord-007714-n3omlvfl 111 12 that that DT cord-007714-n3omlvfl 111 13 of of IN cord-007714-n3omlvfl 111 14 yeast yeast NN cord-007714-n3omlvfl 111 15 , , , cord-007714-n3omlvfl 111 16 in in IN cord-007714-n3omlvfl 111 17 which which WDT cord-007714-n3omlvfl 111 18 the the DT cord-007714-n3omlvfl 111 19 step step NN cord-007714-n3omlvfl 111 20 - - HYPH cord-007714-n3omlvfl 111 21 wise wise JJ cord-007714-n3omlvfl 111 22 cleavage cleavage NN cord-007714-n3omlvfl 111 23 and and CC cord-007714-n3omlvfl 111 24 trimming trimming NN cord-007714-n3omlvfl 111 25 reactions reaction NNS cord-007714-n3omlvfl 111 26 required require VBN cord-007714-n3omlvfl 111 27 for for IN cord-007714-n3omlvfl 111 28 production production NN cord-007714-n3omlvfl 111 29 of of IN cord-007714-n3omlvfl 111 30 mature mature JJ cord-007714-n3omlvfl 111 31 rRNAs rrna NNS cord-007714-n3omlvfl 111 32 have have VBP cord-007714-n3omlvfl 111 33 been be VBN cord-007714-n3omlvfl 111 34 demonstrated demonstrate VBN cord-007714-n3omlvfl 111 35 and and CC cord-007714-n3omlvfl 111 36 in in IN cord-007714-n3omlvfl 111 37 which which WDT cord-007714-n3omlvfl 111 38 many many JJ cord-007714-n3omlvfl 111 39 of of IN cord-007714-n3omlvfl 111 40 the the DT cord-007714-n3omlvfl 111 41 protein protein NN cord-007714-n3omlvfl 111 42 and and CC cord-007714-n3omlvfl 111 43 snoRNP snornp NN cord-007714-n3omlvfl 111 44 components component NNS cord-007714-n3omlvfl 111 45 involved involve VBN cord-007714-n3omlvfl 111 46 have have VBP cord-007714-n3omlvfl 111 47 been be VBN cord-007714-n3omlvfl 111 48 identified identify VBN cord-007714-n3omlvfl 111 49 ( ( -LRB- cord-007714-n3omlvfl 111 50 Venema Venema NNP cord-007714-n3omlvfl 111 51 and and CC cord-007714-n3omlvfl 111 52 Tollervey Tollervey NNP cord-007714-n3omlvfl 111 53 1999 1999 CD cord-007714-n3omlvfl 111 54 ; ; : cord-007714-n3omlvfl 111 55 Fatica Fatica NNP cord-007714-n3omlvfl 111 56 and and CC cord-007714-n3omlvfl 111 57 Tollervey Tollervey NNP cord-007714-n3omlvfl 111 58 2002 2002 CD cord-007714-n3omlvfl 111 59 ) ) -RRB- cord-007714-n3omlvfl 111 60 . . . cord-007714-n3omlvfl 112 1 Initial initial JJ cord-007714-n3omlvfl 112 2 cleavage cleavage NN cord-007714-n3omlvfl 112 3 of of IN cord-007714-n3omlvfl 112 4 the the DT cord-007714-n3omlvfl 112 5 pre pre NN cord-007714-n3omlvfl 112 6 - - JJ cord-007714-n3omlvfl 112 7 rRNA rrna JJ cord-007714-n3omlvfl 112 8 involves involve VBZ cord-007714-n3omlvfl 112 9 the the DT cord-007714-n3omlvfl 112 10 U3 U3 NNP cord-007714-n3omlvfl 112 11 , , , cord-007714-n3omlvfl 112 12 U14 U14 NNP cord-007714-n3omlvfl 112 13 , , , cord-007714-n3omlvfl 112 14 MRP MRP NNP cord-007714-n3omlvfl 112 15 , , , cord-007714-n3omlvfl 112 16 snR10 snr10 CD cord-007714-n3omlvfl 112 17 and and CC cord-007714-n3omlvfl 112 18 snR30 snr30 CD cord-007714-n3omlvfl 112 19 snoRNAs snornas NN cord-007714-n3omlvfl 112 20 and and CC cord-007714-n3omlvfl 112 21 the the DT cord-007714-n3omlvfl 112 22 resultant resultant JJ cord-007714-n3omlvfl 112 23 precursors precursor NNS cord-007714-n3omlvfl 112 24 are be VBP cord-007714-n3omlvfl 112 25 trimmed trim VBN cord-007714-n3omlvfl 112 26 by by IN cord-007714-n3omlvfl 112 27 the the DT cord-007714-n3omlvfl 112 28 action action NN cord-007714-n3omlvfl 112 29 of of IN cord-007714-n3omlvfl 112 30 exonucleases exonuclease NNS cord-007714-n3omlvfl 112 31 : : : cord-007714-n3omlvfl 112 32 Rat1p Rat1p NNP cord-007714-n3omlvfl 112 33 , , , cord-007714-n3omlvfl 112 34 Xrn1p Xrn1p NNP cord-007714-n3omlvfl 112 35 and and CC cord-007714-n3omlvfl 112 36 the the DT cord-007714-n3omlvfl 112 37 exosome exosome NN cord-007714-n3omlvfl 112 38 ( ( -LRB- cord-007714-n3omlvfl 112 39 Venema Venema NNP cord-007714-n3omlvfl 112 40 and and CC cord-007714-n3omlvfl 112 41 Tollervey Tollervey NNP cord-007714-n3omlvfl 112 42 1999 1999 CD cord-007714-n3omlvfl 112 43 ; ; : cord-007714-n3omlvfl 113 1 Fatica Fatica NNP cord-007714-n3omlvfl 113 2 and and CC cord-007714-n3omlvfl 113 3 Tollervey Tollervey NNP cord-007714-n3omlvfl 113 4 2002 2002 CD cord-007714-n3omlvfl 113 5 ) ) -RRB- cord-007714-n3omlvfl 113 6 . . . cord-007714-n3omlvfl 114 1 The the DT cord-007714-n3omlvfl 114 2 pathway pathway NN cord-007714-n3omlvfl 114 3 of of IN cord-007714-n3omlvfl 114 4 processing processing NN cord-007714-n3omlvfl 114 5 and and CC cord-007714-n3omlvfl 114 6 modification modification NN cord-007714-n3omlvfl 114 7 is be VBZ cord-007714-n3omlvfl 114 8 poorly poorly RB cord-007714-n3omlvfl 114 9 understood understand VBN cord-007714-n3omlvfl 114 10 in in IN cord-007714-n3omlvfl 114 11 plants plant NNS cord-007714-n3omlvfl 114 12 but but CC cord-007714-n3omlvfl 114 13 is be VBZ cord-007714-n3omlvfl 114 14 likely likely JJ cord-007714-n3omlvfl 114 15 to to TO cord-007714-n3omlvfl 114 16 contain contain VB cord-007714-n3omlvfl 114 17 many many JJ cord-007714-n3omlvfl 114 18 processing processing NN cord-007714-n3omlvfl 114 19 steps step NNS cord-007714-n3omlvfl 114 20 which which WDT cord-007714-n3omlvfl 114 21 are be VBP cord-007714-n3omlvfl 114 22 conserved conserve VBN cord-007714-n3omlvfl 114 23 with with IN cord-007714-n3omlvfl 114 24 other other JJ cord-007714-n3omlvfl 114 25 eukaryotes eukaryote NNS cord-007714-n3omlvfl 114 26 . . . cord-007714-n3omlvfl 115 1 Nevertheless nevertheless RB cord-007714-n3omlvfl 115 2 , , , cord-007714-n3omlvfl 115 3 significant significant JJ cord-007714-n3omlvfl 115 4 advances advance NNS cord-007714-n3omlvfl 115 5 in in IN cord-007714-n3omlvfl 115 6 understanding understand VBG cord-007714-n3omlvfl 115 7 rRNA rrna NN cord-007714-n3omlvfl 115 8 processing processing NN cord-007714-n3omlvfl 115 9 and and CC cord-007714-n3omlvfl 115 10 the the DT cord-007714-n3omlvfl 115 11 function function NN cord-007714-n3omlvfl 115 12 of of IN cord-007714-n3omlvfl 115 13 nucleolar nucleolar JJ cord-007714-n3omlvfl 115 14 proteins protein NNS cord-007714-n3omlvfl 115 15 have have VBP cord-007714-n3omlvfl 115 16 been be VBN cord-007714-n3omlvfl 115 17 made make VBN cord-007714-n3omlvfl 115 18 recently recently RB cord-007714-n3omlvfl 115 19 . . . cord-007714-n3omlvfl 116 1 In in IN cord-007714-n3omlvfl 116 2 particular particular JJ cord-007714-n3omlvfl 116 3 , , , cord-007714-n3omlvfl 116 4 a a DT cord-007714-n3omlvfl 116 5 multiprotein multiprotein NNP cord-007714-n3omlvfl 116 6 complex complex NN cord-007714-n3omlvfl 116 7 containing contain VBG cord-007714-n3omlvfl 116 8 nucleolin nucleolin NNP cord-007714-n3omlvfl 116 9 , , , cord-007714-n3omlvfl 116 10 fibrillarin fibrillarin NNP cord-007714-n3omlvfl 116 11 , , , cord-007714-n3omlvfl 116 12 U3 U3 NNP cord-007714-n3omlvfl 116 13 and and CC cord-007714-n3omlvfl 116 14 U14 U14 NNP cord-007714-n3omlvfl 116 15 has have VBZ cord-007714-n3omlvfl 116 16 been be VBN cord-007714-n3omlvfl 116 17 shown show VBN cord-007714-n3omlvfl 116 18 to to TO cord-007714-n3omlvfl 116 19 cleave cleave VB cord-007714-n3omlvfl 116 20 the the DT cord-007714-n3omlvfl 116 21 pre pre NN cord-007714-n3omlvfl 116 22 - - NN cord-007714-n3omlvfl 116 23 rRNA rrna NN cord-007714-n3omlvfl 116 24 in in IN cord-007714-n3omlvfl 116 25 the the DT cord-007714-n3omlvfl 116 26 5′ 5′ CD cord-007714-n3omlvfl 116 27 external external JJ cord-007714-n3omlvfl 116 28 transcribed transcribe VBN cord-007714-n3omlvfl 116 29 sequence sequence NN cord-007714-n3omlvfl 116 30 ( ( -LRB- cord-007714-n3omlvfl 116 31 Saez Saez NNP cord-007714-n3omlvfl 116 32 - - HYPH cord-007714-n3omlvfl 116 33 Vasquez Vasquez NNP cord-007714-n3omlvfl 116 34 et et NNP cord-007714-n3omlvfl 116 35 al al NNP cord-007714-n3omlvfl 116 36 . . . cord-007714-n3omlvfl 116 37 2004 2004 CD cord-007714-n3omlvfl 116 38 ) ) -RRB- cord-007714-n3omlvfl 116 39 . . . cord-007714-n3omlvfl 117 1 In in IN cord-007714-n3omlvfl 117 2 addition addition NN cord-007714-n3omlvfl 117 3 , , , cord-007714-n3omlvfl 117 4 the the DT cord-007714-n3omlvfl 117 5 absence absence NN cord-007714-n3omlvfl 117 6 of of IN cord-007714-n3omlvfl 117 7 nucleolin nucleolin JJ cord-007714-n3omlvfl 117 8 expression expression NN cord-007714-n3omlvfl 117 9 causes cause VBZ cord-007714-n3omlvfl 117 10 disruption disruption NN cord-007714-n3omlvfl 117 11 of of IN cord-007714-n3omlvfl 117 12 the the DT cord-007714-n3omlvfl 117 13 structural structural JJ cord-007714-n3omlvfl 117 14 organisation organisation NN cord-007714-n3omlvfl 117 15 of of IN cord-007714-n3omlvfl 117 16 the the DT cord-007714-n3omlvfl 117 17 nucleolus nucleolus NN cord-007714-n3omlvfl 117 18 ( ( -LRB- cord-007714-n3omlvfl 117 19 Pontvianne Pontvianne NNP cord-007714-n3omlvfl 117 20 et et FW cord-007714-n3omlvfl 117 21 al al NNP cord-007714-n3omlvfl 117 22 . . NNP cord-007714-n3omlvfl 117 23 2007 2007 CD cord-007714-n3omlvfl 117 24 ) ) -RRB- cord-007714-n3omlvfl 117 25 . . . cord-007714-n3omlvfl 118 1 Ribosomal Ribosomal NNP cord-007714-n3omlvfl 118 2 RNAs rna NNS cord-007714-n3omlvfl 118 3 contain contain VBP cord-007714-n3omlvfl 118 4 numerous numerous JJ cord-007714-n3omlvfl 118 5 nucleotide nucleotide JJ cord-007714-n3omlvfl 118 6 modifications modification NNS cord-007714-n3omlvfl 118 7 . . . cord-007714-n3omlvfl 119 1 The the DT cord-007714-n3omlvfl 119 2 two two CD cord-007714-n3omlvfl 119 3 major major JJ cord-007714-n3omlvfl 119 4 modifications modification NNS cord-007714-n3omlvfl 119 5 in in IN cord-007714-n3omlvfl 119 6 rRNA rRNA NNS cord-007714-n3omlvfl 119 7 are be VBP cord-007714-n3omlvfl 119 8 2′-O 2′-o CD cord-007714-n3omlvfl 119 9 -ribose -ribose SYM cord-007714-n3omlvfl 119 10 methylation methylation NN cord-007714-n3omlvfl 119 11 and and CC cord-007714-n3omlvfl 119 12 pseudouridylation pseudouridylation NN cord-007714-n3omlvfl 119 13 . . . cord-007714-n3omlvfl 120 1 The the DT cord-007714-n3omlvfl 120 2 sites site NNS cord-007714-n3omlvfl 120 3 of of IN cord-007714-n3omlvfl 120 4 modification modification NN cord-007714-n3omlvfl 120 5 are be VBP cord-007714-n3omlvfl 120 6 determined determine VBN cord-007714-n3omlvfl 120 7 by by IN cord-007714-n3omlvfl 120 8 regions region NNS cord-007714-n3omlvfl 120 9 of of IN cord-007714-n3omlvfl 120 10 complementarity complementarity NN cord-007714-n3omlvfl 120 11 to to IN cord-007714-n3omlvfl 120 12 their -PRON- PRP$ cord-007714-n3omlvfl 120 13 cognate cognate JJ cord-007714-n3omlvfl 120 14 rRNA rrna NN cord-007714-n3omlvfl 120 15 sequences sequence NNS cord-007714-n3omlvfl 120 16 . . . cord-007714-n3omlvfl 121 1 Box Box NNP cord-007714-n3omlvfl 121 2 C C NNP cord-007714-n3omlvfl 121 3 / / SYM cord-007714-n3omlvfl 121 4 D d NN cord-007714-n3omlvfl 121 5 and and CC cord-007714-n3omlvfl 121 6 box box NN cord-007714-n3omlvfl 121 7 H H NNP cord-007714-n3omlvfl 121 8 / / SYM cord-007714-n3omlvfl 121 9 ACA ACA NNP cord-007714-n3omlvfl 122 1 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 122 2 are be VBP cord-007714-n3omlvfl 122 3 responsible responsible JJ cord-007714-n3omlvfl 122 4 for for IN cord-007714-n3omlvfl 122 5 generating generate VBG cord-007714-n3omlvfl 122 6 2′-O 2′-o CD cord-007714-n3omlvfl 122 7 -ribose -ribose : cord-007714-n3omlvfl 122 8 methylation methylation NN cord-007714-n3omlvfl 122 9 and and CC cord-007714-n3omlvfl 122 10 pseudouridylation pseudouridylation NN cord-007714-n3omlvfl 122 11 of of IN cord-007714-n3omlvfl 122 12 nucleotides nucleotide NNS cord-007714-n3omlvfl 122 13 , , , cord-007714-n3omlvfl 122 14 respectively respectively RB cord-007714-n3omlvfl 122 15 ( ( -LRB- cord-007714-n3omlvfl 122 16 Kiss Kiss NNP cord-007714-n3omlvfl 122 17 2002 2002 CD cord-007714-n3omlvfl 122 18 ) ) -RRB- cord-007714-n3omlvfl 122 19 . . . cord-007714-n3omlvfl 123 1 Thus thus RB cord-007714-n3omlvfl 123 2 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 123 3 act act VB cord-007714-n3omlvfl 123 4 as as IN cord-007714-n3omlvfl 123 5 guide guide NN cord-007714-n3omlvfl 123 6 sequences sequence NNS cord-007714-n3omlvfl 123 7 to to TO cord-007714-n3omlvfl 123 8 define define VB cord-007714-n3omlvfl 123 9 which which WDT cord-007714-n3omlvfl 123 10 nucleotides nucleotide NNS cord-007714-n3omlvfl 123 11 in in IN cord-007714-n3omlvfl 123 12 rRNA rRNA NNS cord-007714-n3omlvfl 123 13 are be VBP cord-007714-n3omlvfl 123 14 modified modify VBN cord-007714-n3omlvfl 123 15 . . . cord-007714-n3omlvfl 124 1 In in IN cord-007714-n3omlvfl 124 2 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 124 3 and and CC cord-007714-n3omlvfl 124 4 rice rice NN cord-007714-n3omlvfl 124 5 , , , cord-007714-n3omlvfl 124 6 snoRNA snoRNA NNP cord-007714-n3omlvfl 124 7 genes gene NNS cord-007714-n3omlvfl 124 8 have have VBP cord-007714-n3omlvfl 124 9 been be VBN cord-007714-n3omlvfl 124 10 identified identify VBN cord-007714-n3omlvfl 124 11 by by IN cord-007714-n3omlvfl 124 12 both both DT cord-007714-n3omlvfl 124 13 bioinformatics bioinformatics NN cord-007714-n3omlvfl 124 14 predictions prediction NNS cord-007714-n3omlvfl 124 15 and and CC cord-007714-n3omlvfl 124 16 experimental experimental JJ cord-007714-n3omlvfl 124 17 approaches approach NNS cord-007714-n3omlvfl 124 18 ( ( -LRB- cord-007714-n3omlvfl 124 19 Barneche Barneche NNP cord-007714-n3omlvfl 124 20 et et NNP cord-007714-n3omlvfl 124 21 al al NNP cord-007714-n3omlvfl 124 22 . . NNP cord-007714-n3omlvfl 124 23 2001 2001 CD cord-007714-n3omlvfl 124 24 ; ; : cord-007714-n3omlvfl 124 25 Brown Brown NNP cord-007714-n3omlvfl 124 26 et et NNP cord-007714-n3omlvfl 124 27 al al NNP cord-007714-n3omlvfl 124 28 . . . cord-007714-n3omlvfl 125 1 2001 2001 CD cord-007714-n3omlvfl 126 1 Brown Brown NNP cord-007714-n3omlvfl 126 2 et et NNP cord-007714-n3omlvfl 126 3 al al NNP cord-007714-n3omlvfl 126 4 . . . cord-007714-n3omlvfl 127 1 , , , cord-007714-n3omlvfl 127 2 2003 2003 CD cord-007714-n3omlvfl 128 1 Qu Qu NNP cord-007714-n3omlvfl 128 2 et et NNP cord-007714-n3omlvfl 128 3 al al NNP cord-007714-n3omlvfl 128 4 . . . cord-007714-n3omlvfl 129 1 2001 2001 CD cord-007714-n3omlvfl 129 2 ; ; : cord-007714-n3omlvfl 129 3 Marker Marker NNP cord-007714-n3omlvfl 129 4 et et NNP cord-007714-n3omlvfl 129 5 al al NNP cord-007714-n3omlvfl 129 6 . . . cord-007714-n3omlvfl 129 7 2002 2002 CD cord-007714-n3omlvfl 129 8 ) ) -RRB- cord-007714-n3omlvfl 129 9 . . . cord-007714-n3omlvfl 130 1 Many many JJ cord-007714-n3omlvfl 130 2 of of IN cord-007714-n3omlvfl 130 3 the the DT cord-007714-n3omlvfl 130 4 plant plant NN cord-007714-n3omlvfl 130 5 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 130 6 are be VBP cord-007714-n3omlvfl 130 7 conserved conserve VBN cord-007714-n3omlvfl 130 8 in in IN cord-007714-n3omlvfl 130 9 yeast yeast NN cord-007714-n3omlvfl 130 10 and/or and/or CC cord-007714-n3omlvfl 130 11 human human NN cord-007714-n3omlvfl 130 12 , , , cord-007714-n3omlvfl 130 13 in in IN cord-007714-n3omlvfl 130 14 terms term NNS cord-007714-n3omlvfl 130 15 of of IN cord-007714-n3omlvfl 130 16 the the DT cord-007714-n3omlvfl 130 17 rRNA rRNA NNP cord-007714-n3omlvfl 130 18 target target NN cord-007714-n3omlvfl 130 19 sequences sequence NNS cord-007714-n3omlvfl 130 20 which which WDT cord-007714-n3omlvfl 130 21 are be VBP cord-007714-n3omlvfl 130 22 modified modify VBN cord-007714-n3omlvfl 130 23 , , , cord-007714-n3omlvfl 130 24 but but CC cord-007714-n3omlvfl 130 25 there there EX cord-007714-n3omlvfl 130 26 are be VBP cord-007714-n3omlvfl 130 27 a a DT cord-007714-n3omlvfl 130 28 number number NN cord-007714-n3omlvfl 130 29 of of IN cord-007714-n3omlvfl 130 30 plant plant NN cord-007714-n3omlvfl 130 31 - - HYPH cord-007714-n3omlvfl 130 32 specific specific JJ cord-007714-n3omlvfl 130 33 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 130 34 guiding guide VBG cord-007714-n3omlvfl 130 35 modification modification NN cord-007714-n3omlvfl 130 36 of of IN cord-007714-n3omlvfl 130 37 nucleotides nucleotide NNS cord-007714-n3omlvfl 130 38 in in IN cord-007714-n3omlvfl 130 39 plant plant NN cord-007714-n3omlvfl 130 40 rRNAs rrna NNS cord-007714-n3omlvfl 130 41 which which WDT cord-007714-n3omlvfl 130 42 are be VBP cord-007714-n3omlvfl 130 43 unmodified unmodified JJ cord-007714-n3omlvfl 130 44 in in IN cord-007714-n3omlvfl 130 45 other other JJ cord-007714-n3omlvfl 130 46 organisms organism NNS cord-007714-n3omlvfl 131 1 ( ( -LRB- cord-007714-n3omlvfl 131 2 Barneche Barneche NNP cord-007714-n3omlvfl 131 3 et et NNP cord-007714-n3omlvfl 131 4 al al NNP cord-007714-n3omlvfl 131 5 . . . cord-007714-n3omlvfl 132 1 2001 2001 CD cord-007714-n3omlvfl 132 2 ; ; : cord-007714-n3omlvfl 132 3 Brown Brown NNP cord-007714-n3omlvfl 132 4 et et NNP cord-007714-n3omlvfl 132 5 al al NNP cord-007714-n3omlvfl 132 6 . . . cord-007714-n3omlvfl 133 1 2001 2001 CD cord-007714-n3omlvfl 133 2 ; ; : cord-007714-n3omlvfl 133 3 Qu Qu NNP cord-007714-n3omlvfl 133 4 et et NNP cord-007714-n3omlvfl 133 5 al al NNP cord-007714-n3omlvfl 133 6 . . . cord-007714-n3omlvfl 134 1 2001 2001 CD cord-007714-n3omlvfl 134 2 ; ; : cord-007714-n3omlvfl 134 3 Marker Marker NNP cord-007714-n3omlvfl 134 4 et et NNP cord-007714-n3omlvfl 134 5 al al NNP cord-007714-n3omlvfl 134 6 . . . cord-007714-n3omlvfl 134 7 2002 2002 CD cord-007714-n3omlvfl 134 8 ) ) -RRB- cord-007714-n3omlvfl 134 9 . . . cord-007714-n3omlvfl 135 1 The the DT cord-007714-n3omlvfl 135 2 fact fact NN cord-007714-n3omlvfl 135 3 that that IN cord-007714-n3omlvfl 135 4 so so RB cord-007714-n3omlvfl 135 5 many many JJ cord-007714-n3omlvfl 135 6 nucleotide nucleotide JJ cord-007714-n3omlvfl 135 7 modifications modification NNS cord-007714-n3omlvfl 135 8 are be VBP cord-007714-n3omlvfl 135 9 conserved conserve VBN cord-007714-n3omlvfl 135 10 in in IN cord-007714-n3omlvfl 135 11 eukaryotic eukaryotic JJ cord-007714-n3omlvfl 135 12 rRNAs rRNAs NNPS cord-007714-n3omlvfl 135 13 suggests suggest VBZ cord-007714-n3omlvfl 135 14 important important JJ cord-007714-n3omlvfl 135 15 functions function NNS cord-007714-n3omlvfl 135 16 in in IN cord-007714-n3omlvfl 135 17 rRNA rrna JJ cord-007714-n3omlvfl 135 18 processing processing NN cord-007714-n3omlvfl 135 19 or or CC cord-007714-n3omlvfl 135 20 ribosome ribosome NN cord-007714-n3omlvfl 135 21 activity activity NN cord-007714-n3omlvfl 135 22 . . . cord-007714-n3omlvfl 136 1 The the DT cord-007714-n3omlvfl 136 2 majority majority NN cord-007714-n3omlvfl 136 3 of of IN cord-007714-n3omlvfl 136 4 nucleotide nucleotide JJ cord-007714-n3omlvfl 136 5 modifications modification NNS cord-007714-n3omlvfl 136 6 are be VBP cord-007714-n3omlvfl 136 7 in in IN cord-007714-n3omlvfl 136 8 the the DT cord-007714-n3omlvfl 136 9 active active JJ cord-007714-n3omlvfl 136 10 sites site NNS cord-007714-n3omlvfl 136 11 of of IN cord-007714-n3omlvfl 136 12 the the DT cord-007714-n3omlvfl 136 13 ribosome ribosome NN cord-007714-n3omlvfl 136 14 and and CC cord-007714-n3omlvfl 136 15 are be VBP cord-007714-n3omlvfl 136 16 thought think VBN cord-007714-n3omlvfl 136 17 to to TO cord-007714-n3omlvfl 136 18 influence influence VB cord-007714-n3omlvfl 136 19 the the DT cord-007714-n3omlvfl 136 20 efficiency efficiency NN cord-007714-n3omlvfl 136 21 of of IN cord-007714-n3omlvfl 136 22 the the DT cord-007714-n3omlvfl 136 23 ribosome ribosome NN cord-007714-n3omlvfl 136 24 and and CC cord-007714-n3omlvfl 136 25 protein protein NN cord-007714-n3omlvfl 136 26 translation translation NN cord-007714-n3omlvfl 136 27 ( ( -LRB- cord-007714-n3omlvfl 136 28 Decatur Decatur NNP cord-007714-n3omlvfl 136 29 and and CC cord-007714-n3omlvfl 136 30 Fournier Fournier NNP cord-007714-n3omlvfl 136 31 2002 2002 CD cord-007714-n3omlvfl 136 32 ) ) -RRB- cord-007714-n3omlvfl 136 33 . . . cord-007714-n3omlvfl 137 1 The the DT cord-007714-n3omlvfl 137 2 eukaryotic eukaryotic JJ cord-007714-n3omlvfl 137 3 ribosome ribosome NN cord-007714-n3omlvfl 137 4 consists consist VBZ cord-007714-n3omlvfl 137 5 of of IN cord-007714-n3omlvfl 137 6 a a DT cord-007714-n3omlvfl 137 7 small small JJ cord-007714-n3omlvfl 137 8 ( ( -LRB- cord-007714-n3omlvfl 137 9 40S 40s CD cord-007714-n3omlvfl 137 10 ) ) -RRB- cord-007714-n3omlvfl 137 11 and and CC cord-007714-n3omlvfl 137 12 a a DT cord-007714-n3omlvfl 137 13 large large JJ cord-007714-n3omlvfl 137 14 ( ( -LRB- cord-007714-n3omlvfl 137 15 60S 60s CD cord-007714-n3omlvfl 137 16 ) ) -RRB- cord-007714-n3omlvfl 137 17 subunit subunit NN cord-007714-n3omlvfl 137 18 containing contain VBG cord-007714-n3omlvfl 137 19 the the DT cord-007714-n3omlvfl 137 20 5S 5s NN cord-007714-n3omlvfl 137 21 , , , cord-007714-n3omlvfl 137 22 5.8S 5.8s CD cord-007714-n3omlvfl 137 23 , , , cord-007714-n3omlvfl 137 24 18S 18S NNPS cord-007714-n3omlvfl 137 25 and and CC cord-007714-n3omlvfl 137 26 26 26 CD cord-007714-n3omlvfl 137 27 - - HYPH cord-007714-n3omlvfl 137 28 28S 28S NNP cord-007714-n3omlvfl 137 29 rRNAs rRNAs NNPS cord-007714-n3omlvfl 137 30 associated associate VBN cord-007714-n3omlvfl 137 31 with with IN cord-007714-n3omlvfl 137 32 around around RB cord-007714-n3omlvfl 137 33 80 80 CD cord-007714-n3omlvfl 137 34 ribosomal ribosomal JJ cord-007714-n3omlvfl 137 35 proteins protein NNS cord-007714-n3omlvfl 137 36 ( ( -LRB- cord-007714-n3omlvfl 137 37 Tate Tate NNP cord-007714-n3omlvfl 137 38 and and CC cord-007714-n3omlvfl 137 39 Poole Poole NNP cord-007714-n3omlvfl 137 40 2004 2004 CD cord-007714-n3omlvfl 137 41 ) ) -RRB- cord-007714-n3omlvfl 137 42 . . . cord-007714-n3omlvfl 138 1 As as IN cord-007714-n3omlvfl 138 2 with with IN cord-007714-n3omlvfl 138 3 other other JJ cord-007714-n3omlvfl 138 4 large large JJ cord-007714-n3omlvfl 138 5 RNP RNP NNP cord-007714-n3omlvfl 138 6 complexes complex NNS cord-007714-n3omlvfl 138 7 such such JJ cord-007714-n3omlvfl 138 8 as as IN cord-007714-n3omlvfl 138 9 the the DT cord-007714-n3omlvfl 138 10 spliceosome spliceosome NNP cord-007714-n3omlvfl 138 11 , , , cord-007714-n3omlvfl 138 12 correct correct JJ cord-007714-n3omlvfl 138 13 assembly assembly NN cord-007714-n3omlvfl 138 14 occurs occur VBZ cord-007714-n3omlvfl 138 15 in in IN cord-007714-n3omlvfl 138 16 a a DT cord-007714-n3omlvfl 138 17 regulated regulated JJ cord-007714-n3omlvfl 138 18 and and CC cord-007714-n3omlvfl 138 19 co co JJ cord-007714-n3omlvfl 138 20 - - JJ cord-007714-n3omlvfl 138 21 ordinated ordinated JJ cord-007714-n3omlvfl 138 22 step step NN cord-007714-n3omlvfl 138 23 - - HYPH cord-007714-n3omlvfl 138 24 wise wise JJ cord-007714-n3omlvfl 138 25 pathway pathway NN cord-007714-n3omlvfl 138 26 involving involve VBG cord-007714-n3omlvfl 138 27 non non JJ cord-007714-n3omlvfl 138 28 - - JJ cord-007714-n3omlvfl 138 29 ribosome ribosome JJ cord-007714-n3omlvfl 138 30 factors factor NNS cord-007714-n3omlvfl 138 31 and and CC cord-007714-n3omlvfl 138 32 ribosomal ribosomal JJ cord-007714-n3omlvfl 138 33 proteins protein NNS cord-007714-n3omlvfl 138 34 required require VBN cord-007714-n3omlvfl 138 35 for for IN cord-007714-n3omlvfl 138 36 correct correct JJ cord-007714-n3omlvfl 138 37 rRNA rRNA NNP cord-007714-n3omlvfl 138 38 folding folding NN cord-007714-n3omlvfl 138 39 , , , cord-007714-n3omlvfl 138 40 protein protein NNP cord-007714-n3omlvfl 138 41 association association NNP cord-007714-n3omlvfl 138 42 and and CC cord-007714-n3omlvfl 138 43 ultimately ultimately RB cord-007714-n3omlvfl 138 44 export export NN cord-007714-n3omlvfl 138 45 of of IN cord-007714-n3omlvfl 138 46 the the DT cord-007714-n3omlvfl 138 47 ribosomal ribosomal JJ cord-007714-n3omlvfl 138 48 subunits subunit NNS cord-007714-n3omlvfl 138 49 through through IN cord-007714-n3omlvfl 138 50 the the DT cord-007714-n3omlvfl 138 51 nuclear nuclear JJ cord-007714-n3omlvfl 138 52 pore pore NN cord-007714-n3omlvfl 138 53 complex complex NN cord-007714-n3omlvfl 138 54 to to IN cord-007714-n3omlvfl 138 55 the the DT cord-007714-n3omlvfl 138 56 cytoplasm cytoplasm NN cord-007714-n3omlvfl 139 1 ( ( -LRB- cord-007714-n3omlvfl 139 2 Venema Venema NNP cord-007714-n3omlvfl 139 3 and and CC cord-007714-n3omlvfl 139 4 Tollervey Tollervey NNP cord-007714-n3omlvfl 139 5 1999 1999 CD cord-007714-n3omlvfl 139 6 ; ; : cord-007714-n3omlvfl 139 7 Fatica Fatica NNP cord-007714-n3omlvfl 139 8 and and CC cord-007714-n3omlvfl 139 9 Tollervey Tollervey NNP cord-007714-n3omlvfl 139 10 2002 2002 CD cord-007714-n3omlvfl 139 11 ; ; : cord-007714-n3omlvfl 139 12 Grannemann Grannemann NNP cord-007714-n3omlvfl 139 13 and and CC cord-007714-n3omlvfl 139 14 Baserga Baserga NNP cord-007714-n3omlvfl 139 15 2004 2004 CD cord-007714-n3omlvfl 139 16 ) ) -RRB- cord-007714-n3omlvfl 139 17 . . . cord-007714-n3omlvfl 140 1 The the DT cord-007714-n3omlvfl 140 2 pre pre JJ cord-007714-n3omlvfl 140 3 - - JJ cord-007714-n3omlvfl 140 4 rRNA rrna JJ cord-007714-n3omlvfl 140 5 transcript transcript NN cord-007714-n3omlvfl 140 6 is be VBZ cord-007714-n3omlvfl 140 7 assembled assemble VBN cord-007714-n3omlvfl 140 8 into into IN cord-007714-n3omlvfl 140 9 a a DT cord-007714-n3omlvfl 140 10 90S 90s CD cord-007714-n3omlvfl 140 11 pre pre JJ cord-007714-n3omlvfl 140 12 - - JJ cord-007714-n3omlvfl 140 13 ribosome ribosome JJ cord-007714-n3omlvfl 140 14 containing containing NN cord-007714-n3omlvfl 140 15 factors factor NNS cord-007714-n3omlvfl 140 16 required require VBN cord-007714-n3omlvfl 140 17 for for IN cord-007714-n3omlvfl 140 18 formation formation NN cord-007714-n3omlvfl 140 19 of of IN cord-007714-n3omlvfl 140 20 both both DT cord-007714-n3omlvfl 140 21 ribosomal ribosomal JJ cord-007714-n3omlvfl 140 22 subunits subunit NNS cord-007714-n3omlvfl 140 23 . . . cord-007714-n3omlvfl 141 1 Cleavage cleavage NN cord-007714-n3omlvfl 141 2 of of IN cord-007714-n3omlvfl 141 3 the the DT cord-007714-n3omlvfl 141 4 primary primary JJ cord-007714-n3omlvfl 141 5 transcript transcript NN cord-007714-n3omlvfl 141 6 gives give VBZ cord-007714-n3omlvfl 141 7 rise rise NN cord-007714-n3omlvfl 141 8 to to IN cord-007714-n3omlvfl 141 9 pre pre VB cord-007714-n3omlvfl 141 10 - - VB cord-007714-n3omlvfl 141 11 ribosomes ribosome NNS cord-007714-n3omlvfl 141 12 which which WDT cord-007714-n3omlvfl 141 13 with with IN cord-007714-n3omlvfl 141 14 further further JJ cord-007714-n3omlvfl 141 15 processing processing NN cord-007714-n3omlvfl 141 16 and and CC cord-007714-n3omlvfl 141 17 assembly assembly NN cord-007714-n3omlvfl 141 18 produce produce VBP cord-007714-n3omlvfl 141 19 the the DT cord-007714-n3omlvfl 141 20 40S 40s CD cord-007714-n3omlvfl 141 21 and and CC cord-007714-n3omlvfl 141 22 60S 60s CD cord-007714-n3omlvfl 141 23 ribosomal ribosomal JJ cord-007714-n3omlvfl 141 24 subunits subunit NNS cord-007714-n3omlvfl 141 25 ( ( -LRB- cord-007714-n3omlvfl 141 26 Fatica Fatica NNP cord-007714-n3omlvfl 141 27 and and CC cord-007714-n3omlvfl 141 28 Tollervey Tollervey NNP cord-007714-n3omlvfl 141 29 2002 2002 CD cord-007714-n3omlvfl 141 30 ; ; : cord-007714-n3omlvfl 142 1 Grannemann Grannemann NNP cord-007714-n3omlvfl 142 2 and and CC cord-007714-n3omlvfl 142 3 Baserga Baserga NNP cord-007714-n3omlvfl 142 4 2004 2004 CD cord-007714-n3omlvfl 142 5 ) ) -RRB- cord-007714-n3omlvfl 142 6 . . . cord-007714-n3omlvfl 143 1 One one CD cord-007714-n3omlvfl 143 2 of of IN cord-007714-n3omlvfl 143 3 these these DT cord-007714-n3omlvfl 143 4 pre pre JJ cord-007714-n3omlvfl 143 5 - - JJ cord-007714-n3omlvfl 143 6 ribosomal ribosomal JJ cord-007714-n3omlvfl 143 7 complexes complex NNS cord-007714-n3omlvfl 143 8 includes include VBZ cord-007714-n3omlvfl 143 9 the the DT cord-007714-n3omlvfl 143 10 small small JJ cord-007714-n3omlvfl 143 11 subunit subunit NN cord-007714-n3omlvfl 143 12 ( ( -LRB- cord-007714-n3omlvfl 143 13 SSU SSU NNP cord-007714-n3omlvfl 143 14 ) ) -RRB- cord-007714-n3omlvfl 143 15 processosome processosome NNP cord-007714-n3omlvfl 143 16 which which WDT cord-007714-n3omlvfl 143 17 contains contain VBZ cord-007714-n3omlvfl 143 18 the the DT cord-007714-n3omlvfl 143 19 U3snoRNP U3snoRNP NNP cord-007714-n3omlvfl 143 20 along along RP cord-007714-n3omlvfl 143 21 with with IN cord-007714-n3omlvfl 143 22 ribosomal ribosomal NN cord-007714-n3omlvfl 143 23 and and CC cord-007714-n3omlvfl 143 24 nonribosomal nonribosomal JJ cord-007714-n3omlvfl 143 25 proteins protein NNS cord-007714-n3omlvfl 143 26 including include VBG cord-007714-n3omlvfl 143 27 novel novel JJ cord-007714-n3omlvfl 143 28 Utp Utp NNP cord-007714-n3omlvfl 143 29 proteins protein NNS cord-007714-n3omlvfl 143 30 ( ( -LRB- cord-007714-n3omlvfl 143 31 Dragon Dragon NNP cord-007714-n3omlvfl 143 32 et et NNP cord-007714-n3omlvfl 143 33 al al NNP cord-007714-n3omlvfl 143 34 . . . cord-007714-n3omlvfl 143 35 2002 2002 CD cord-007714-n3omlvfl 143 36 ; ; : cord-007714-n3omlvfl 143 37 Grandi Grandi NNP cord-007714-n3omlvfl 143 38 et et NNP cord-007714-n3omlvfl 143 39 al al NNP cord-007714-n3omlvfl 143 40 . . . cord-007714-n3omlvfl 144 1 2002 2002 CD cord-007714-n3omlvfl 144 2 ; ; : cord-007714-n3omlvfl 144 3 Schafer Schafer NNP cord-007714-n3omlvfl 144 4 et et NNP cord-007714-n3omlvfl 144 5 al al NNP cord-007714-n3omlvfl 144 6 . . NNP cord-007714-n3omlvfl 144 7 2003 2003 CD cord-007714-n3omlvfl 144 8 ) ) -RRB- cord-007714-n3omlvfl 144 9 . . . cord-007714-n3omlvfl 145 1 The the DT cord-007714-n3omlvfl 145 2 SSU SSU NNP cord-007714-n3omlvfl 145 3 processosome processosome NN cord-007714-n3omlvfl 145 4 complex complex NN cord-007714-n3omlvfl 145 5 is be VBZ cord-007714-n3omlvfl 145 6 thought think VBN cord-007714-n3omlvfl 145 7 to to TO cord-007714-n3omlvfl 145 8 be be VB cord-007714-n3omlvfl 145 9 the the DT cord-007714-n3omlvfl 145 10 RNP RNP NNP cord-007714-n3omlvfl 145 11 complex complex NN cord-007714-n3omlvfl 145 12 previously previously RB cord-007714-n3omlvfl 145 13 observed observe VBD cord-007714-n3omlvfl 145 14 as as IN cord-007714-n3omlvfl 145 15 knobs knob NNS cord-007714-n3omlvfl 145 16 at at IN cord-007714-n3omlvfl 145 17 the the DT cord-007714-n3omlvfl 145 18 5′ 5′ CD cord-007714-n3omlvfl 145 19 regions region NNS cord-007714-n3omlvfl 145 20 of of IN cord-007714-n3omlvfl 145 21 pre pre JJ cord-007714-n3omlvfl 145 22 - - JJ cord-007714-n3omlvfl 145 23 rRNA rrna JJ cord-007714-n3omlvfl 145 24 transcripts transcript NNS cord-007714-n3omlvfl 145 25 ( ( -LRB- cord-007714-n3omlvfl 145 26 Miller Miller NNP cord-007714-n3omlvfl 145 27 and and CC cord-007714-n3omlvfl 145 28 Beatty Beatty NNP cord-007714-n3omlvfl 145 29 1969 1969 CD cord-007714-n3omlvfl 145 30 ) ) -RRB- cord-007714-n3omlvfl 145 31 . . . cord-007714-n3omlvfl 146 1 In in IN cord-007714-n3omlvfl 146 2 plants plant NNS cord-007714-n3omlvfl 146 3 , , , cord-007714-n3omlvfl 146 4 very very RB cord-007714-n3omlvfl 146 5 little little JJ cord-007714-n3omlvfl 146 6 is be VBZ cord-007714-n3omlvfl 146 7 known know VBN cord-007714-n3omlvfl 146 8 about about IN cord-007714-n3omlvfl 146 9 ribosomal ribosomal JJ cord-007714-n3omlvfl 146 10 subunit subunit NN cord-007714-n3omlvfl 146 11 assembly assembly NN cord-007714-n3omlvfl 146 12 apart apart RB cord-007714-n3omlvfl 146 13 from from IN cord-007714-n3omlvfl 146 14 detailed detailed JJ cord-007714-n3omlvfl 146 15 analyses analysis NNS cord-007714-n3omlvfl 146 16 of of IN cord-007714-n3omlvfl 146 17 the the DT cord-007714-n3omlvfl 146 18 ribosomal ribosomal JJ cord-007714-n3omlvfl 146 19 protein protein NN cord-007714-n3omlvfl 146 20 complement complement NN cord-007714-n3omlvfl 146 21 ( ( -LRB- cord-007714-n3omlvfl 146 22 Barakat Barakat NNP cord-007714-n3omlvfl 146 23 et et NNP cord-007714-n3omlvfl 146 24 al al NNP cord-007714-n3omlvfl 146 25 . . NNP cord-007714-n3omlvfl 146 26 2001 2001 CD cord-007714-n3omlvfl 146 27 ) ) -RRB- cord-007714-n3omlvfl 146 28 and and CC cord-007714-n3omlvfl 146 29 the the DT cord-007714-n3omlvfl 146 30 identification identification NN cord-007714-n3omlvfl 146 31 of of IN cord-007714-n3omlvfl 146 32 orthologues orthologue NNS cord-007714-n3omlvfl 146 33 of of IN cord-007714-n3omlvfl 146 34 some some DT cord-007714-n3omlvfl 146 35 yeast yeast NN cord-007714-n3omlvfl 146 36 and and CC cord-007714-n3omlvfl 146 37 human human JJ cord-007714-n3omlvfl 146 38 associated associate VBN cord-007714-n3omlvfl 146 39 factors factor NNS cord-007714-n3omlvfl 146 40 by by IN cord-007714-n3omlvfl 146 41 , , , cord-007714-n3omlvfl 146 42 for for IN cord-007714-n3omlvfl 146 43 example example NN cord-007714-n3omlvfl 146 44 , , , cord-007714-n3omlvfl 146 45 nucleolar nucleolar JJ cord-007714-n3omlvfl 146 46 proteomics proteomic NNS cord-007714-n3omlvfl 146 47 ( ( -LRB- cord-007714-n3omlvfl 146 48 Pendle Pendle NNP cord-007714-n3omlvfl 146 49 et et NNP cord-007714-n3omlvfl 146 50 al al NNP cord-007714-n3omlvfl 146 51 . . NNP cord-007714-n3omlvfl 146 52 2005 2005 CD cord-007714-n3omlvfl 146 53 ) ) -RRB- cord-007714-n3omlvfl 146 54 . . . cord-007714-n3omlvfl 147 1 Thus thus RB cord-007714-n3omlvfl 147 2 the the DT cord-007714-n3omlvfl 147 3 biochemistry biochemistry NN cord-007714-n3omlvfl 147 4 of of IN cord-007714-n3omlvfl 147 5 rRNA rRNA NNP cord-007714-n3omlvfl 147 6 processing processing NN cord-007714-n3omlvfl 147 7 and and CC cord-007714-n3omlvfl 147 8 ribosome ribosome NN cord-007714-n3omlvfl 147 9 assembly assembly NN cord-007714-n3omlvfl 147 10 lags lag VBZ cord-007714-n3omlvfl 147 11 significantly significantly RB cord-007714-n3omlvfl 147 12 behind behind IN cord-007714-n3omlvfl 147 13 that that DT cord-007714-n3omlvfl 147 14 of of IN cord-007714-n3omlvfl 147 15 yeast yeast NN cord-007714-n3omlvfl 147 16 and and CC cord-007714-n3omlvfl 147 17 animal animal NN cord-007714-n3omlvfl 147 18 systems system NNS cord-007714-n3omlvfl 147 19 . . . cord-007714-n3omlvfl 148 1 Evidence evidence NN cord-007714-n3omlvfl 148 2 for for IN cord-007714-n3omlvfl 148 3 the the DT cord-007714-n3omlvfl 148 4 nucleolus nucleolus NN cord-007714-n3omlvfl 148 5 having have VBG cord-007714-n3omlvfl 148 6 functions function NNS cord-007714-n3omlvfl 148 7 other other JJ cord-007714-n3omlvfl 148 8 than than IN cord-007714-n3omlvfl 148 9 rRNA rRNA NNP cord-007714-n3omlvfl 148 10 transcription transcription NN cord-007714-n3omlvfl 148 11 / / SYM cord-007714-n3omlvfl 148 12 processing processing NN cord-007714-n3omlvfl 148 13 and and CC cord-007714-n3omlvfl 148 14 ribosome ribosome NN cord-007714-n3omlvfl 148 15 assembly assembly NN cord-007714-n3omlvfl 148 16 continues continue VBZ cord-007714-n3omlvfl 148 17 to to TO cord-007714-n3omlvfl 148 18 increase increase VB cord-007714-n3omlvfl 148 19 . . . cord-007714-n3omlvfl 149 1 These these DT cord-007714-n3omlvfl 149 2 functions function NNS cord-007714-n3omlvfl 149 3 can can MD cord-007714-n3omlvfl 149 4 be be VB cord-007714-n3omlvfl 149 5 grouped group VBN cord-007714-n3omlvfl 149 6 into into IN cord-007714-n3omlvfl 149 7 RNA rna NN cord-007714-n3omlvfl 149 8 processing processing NN cord-007714-n3omlvfl 149 9 activities activity NNS cord-007714-n3omlvfl 149 10 , , , cord-007714-n3omlvfl 149 11 often often RB cord-007714-n3omlvfl 149 12 associated associate VBN cord-007714-n3omlvfl 149 13 with with IN cord-007714-n3omlvfl 149 14 RNP RNP NNP cord-007714-n3omlvfl 149 15 assembly assembly NN cord-007714-n3omlvfl 149 16 , , , cord-007714-n3omlvfl 149 17 mRNA mrna NN cord-007714-n3omlvfl 149 18 metabolism metabolism NN cord-007714-n3omlvfl 149 19 , , , cord-007714-n3omlvfl 149 20 and and CC cord-007714-n3omlvfl 149 21 regulatory regulatory JJ cord-007714-n3omlvfl 149 22 cellular cellular JJ cord-007714-n3omlvfl 149 23 functions function NNS cord-007714-n3omlvfl 149 24 such such JJ cord-007714-n3omlvfl 149 25 as as IN cord-007714-n3omlvfl 149 26 the the DT cord-007714-n3omlvfl 149 27 control control NN cord-007714-n3omlvfl 149 28 of of IN cord-007714-n3omlvfl 149 29 the the DT cord-007714-n3omlvfl 149 30 cell cell NN cord-007714-n3omlvfl 149 31 cycle cycle NN cord-007714-n3omlvfl 149 32 and and CC cord-007714-n3omlvfl 149 33 cell cell NN cord-007714-n3omlvfl 149 34 aging aging NN cord-007714-n3omlvfl 149 35 and and CC cord-007714-n3omlvfl 149 36 as as IN cord-007714-n3omlvfl 149 37 a a DT cord-007714-n3omlvfl 149 38 sensor sensor NN cord-007714-n3omlvfl 149 39 of of IN cord-007714-n3omlvfl 149 40 cell cell NN cord-007714-n3omlvfl 149 41 stress stress NN cord-007714-n3omlvfl 149 42 ( ( -LRB- cord-007714-n3omlvfl 149 43 Fig Fig NNP cord-007714-n3omlvfl 149 44 . . NNP cord-007714-n3omlvfl 149 45 2 2 CD cord-007714-n3omlvfl 149 46 ) ) -RRB- cord-007714-n3omlvfl 149 47 . . . cord-007714-n3omlvfl 150 1 In in IN cord-007714-n3omlvfl 150 2 many many JJ cord-007714-n3omlvfl 150 3 cases case NNS cord-007714-n3omlvfl 150 4 , , , cord-007714-n3omlvfl 150 5 evidence evidence NN cord-007714-n3omlvfl 150 6 currently currently RB cord-007714-n3omlvfl 150 7 comes come VBZ cord-007714-n3omlvfl 150 8 from from IN cord-007714-n3omlvfl 150 9 only only RB cord-007714-n3omlvfl 150 10 one one CD cord-007714-n3omlvfl 150 11 organism organism NN cord-007714-n3omlvfl 150 12 , , , cord-007714-n3omlvfl 150 13 making make VBG cord-007714-n3omlvfl 150 14 extrapolation extrapolation NN cord-007714-n3omlvfl 150 15 to to IN cord-007714-n3omlvfl 150 16 a a DT cord-007714-n3omlvfl 150 17 general general JJ cord-007714-n3omlvfl 150 18 nucleolar nucleolar JJ cord-007714-n3omlvfl 150 19 function function NN cord-007714-n3omlvfl 150 20 difficult difficult JJ cord-007714-n3omlvfl 150 21 . . . cord-007714-n3omlvfl 151 1 Nevertheless nevertheless RB cord-007714-n3omlvfl 151 2 , , , cord-007714-n3omlvfl 151 3 the the DT cord-007714-n3omlvfl 151 4 novel novel JJ cord-007714-n3omlvfl 151 5 functions function NNS cord-007714-n3omlvfl 151 6 illustrate illustrate VBP cord-007714-n3omlvfl 151 7 the the DT cord-007714-n3omlvfl 151 8 potential potential JJ cord-007714-n3omlvfl 151 9 complexity complexity NN cord-007714-n3omlvfl 151 10 of of IN cord-007714-n3omlvfl 151 11 the the DT cord-007714-n3omlvfl 151 12 nucleolus nucleolus NN cord-007714-n3omlvfl 151 13 . . . cord-007714-n3omlvfl 152 1 The the DT cord-007714-n3omlvfl 152 2 various various JJ cord-007714-n3omlvfl 152 3 functions function NNS cord-007714-n3omlvfl 152 4 of of IN cord-007714-n3omlvfl 152 5 the the DT cord-007714-n3omlvfl 152 6 nucleolus nucleolus NN cord-007714-n3omlvfl 152 7 have have VBP cord-007714-n3omlvfl 152 8 been be VBN cord-007714-n3omlvfl 152 9 reviewed review VBN cord-007714-n3omlvfl 152 10 previously previously RB cord-007714-n3omlvfl 152 11 ( ( -LRB- cord-007714-n3omlvfl 152 12 Pederson Pederson NNP cord-007714-n3omlvfl 152 13 1999 1999 CD cord-007714-n3omlvfl 152 14 ; ; : cord-007714-n3omlvfl 152 15 Olsen Olsen NNP cord-007714-n3omlvfl 152 16 2004 2004 CD cord-007714-n3omlvfl 152 17 ; ; : cord-007714-n3omlvfl 152 18 Boisvert Boisvert NNP cord-007714-n3omlvfl 152 19 et et NNP cord-007714-n3omlvfl 152 20 al al NNP cord-007714-n3omlvfl 152 21 . . NNP cord-007714-n3omlvfl 152 22 2007 2007 CD cord-007714-n3omlvfl 152 23 ) ) -RRB- cord-007714-n3omlvfl 153 1 and and CC cord-007714-n3omlvfl 153 2 here here RB cord-007714-n3omlvfl 153 3 we -PRON- PRP cord-007714-n3omlvfl 153 4 briefly briefly RB cord-007714-n3omlvfl 153 5 describe describe VBP cord-007714-n3omlvfl 153 6 the the DT cord-007714-n3omlvfl 153 7 roles role NNS cord-007714-n3omlvfl 153 8 of of IN cord-007714-n3omlvfl 153 9 the the DT cord-007714-n3omlvfl 153 10 nucleolus nucleolus NN cord-007714-n3omlvfl 153 11 in in IN cord-007714-n3omlvfl 153 12 RNA RNA NNP cord-007714-n3omlvfl 153 13 processing processing NN cord-007714-n3omlvfl 153 14 and and CC cord-007714-n3omlvfl 153 15 RNP RNP NNP cord-007714-n3omlvfl 153 16 assembly assembly NN cord-007714-n3omlvfl 153 17 . . . cord-007714-n3omlvfl 154 1 The the DT cord-007714-n3omlvfl 154 2 signal signal NN cord-007714-n3omlvfl 154 3 recognition recognition NN cord-007714-n3omlvfl 154 4 particle particle NN cord-007714-n3omlvfl 154 5 ( ( -LRB- cord-007714-n3omlvfl 154 6 SRP SRP NNP cord-007714-n3omlvfl 154 7 ) ) -RRB- cord-007714-n3omlvfl 154 8 is be VBZ cord-007714-n3omlvfl 154 9 a a DT cord-007714-n3omlvfl 154 10 small small JJ cord-007714-n3omlvfl 154 11 RNP rnp NN cord-007714-n3omlvfl 154 12 involved involve VBN cord-007714-n3omlvfl 154 13 in in IN cord-007714-n3omlvfl 154 14 targeting target VBG cord-007714-n3omlvfl 154 15 the the DT cord-007714-n3omlvfl 154 16 translation translation NN cord-007714-n3omlvfl 154 17 of of IN cord-007714-n3omlvfl 154 18 specific specific JJ cord-007714-n3omlvfl 154 19 proteins protein NNS cord-007714-n3omlvfl 154 20 to to IN cord-007714-n3omlvfl 154 21 the the DT cord-007714-n3omlvfl 154 22 endoplasmic endoplasmic NN cord-007714-n3omlvfl 154 23 reticulum reticulum NN cord-007714-n3omlvfl 154 24 . . . cord-007714-n3omlvfl 155 1 SRP SRP NNP cord-007714-n3omlvfl 155 2 consists consist VBZ cord-007714-n3omlvfl 155 3 of of IN cord-007714-n3omlvfl 155 4 the the DT cord-007714-n3omlvfl 155 5 SRP SRP NNP cord-007714-n3omlvfl 155 6 RNA RNA NNP cord-007714-n3omlvfl 155 7 associated associate VBN cord-007714-n3omlvfl 155 8 with with IN cord-007714-n3omlvfl 155 9 specific specific JJ cord-007714-n3omlvfl 155 10 proteins protein NNS cord-007714-n3omlvfl 155 11 ( ( -LRB- cord-007714-n3omlvfl 155 12 Walter Walter NNP cord-007714-n3omlvfl 155 13 and and CC cord-007714-n3omlvfl 155 14 Johnson Johnson NNP cord-007714-n3omlvfl 155 15 1994 1994 CD cord-007714-n3omlvfl 155 16 ) ) -RRB- cord-007714-n3omlvfl 155 17 . . . cord-007714-n3omlvfl 156 1 At at IN cord-007714-n3omlvfl 156 2 least least JJS cord-007714-n3omlvfl 156 3 part part NN cord-007714-n3omlvfl 156 4 of of IN cord-007714-n3omlvfl 156 5 the the DT cord-007714-n3omlvfl 156 6 assembly assembly NN cord-007714-n3omlvfl 156 7 of of IN cord-007714-n3omlvfl 156 8 the the DT cord-007714-n3omlvfl 156 9 SRP SRP NNP cord-007714-n3omlvfl 156 10 has have VBZ cord-007714-n3omlvfl 156 11 been be VBN cord-007714-n3omlvfl 156 12 shown show VBN cord-007714-n3omlvfl 156 13 to to TO cord-007714-n3omlvfl 156 14 occur occur VB cord-007714-n3omlvfl 156 15 in in IN cord-007714-n3omlvfl 156 16 the the DT cord-007714-n3omlvfl 156 17 nucleolus nucleolus NN cord-007714-n3omlvfl 156 18 . . . cord-007714-n3omlvfl 157 1 Most Most JJS cord-007714-n3omlvfl 157 2 , , , cord-007714-n3omlvfl 157 3 but but CC cord-007714-n3omlvfl 157 4 not not RB cord-007714-n3omlvfl 157 5 all all DT cord-007714-n3omlvfl 157 6 , , , cord-007714-n3omlvfl 157 7 of of IN cord-007714-n3omlvfl 157 8 the the DT cord-007714-n3omlvfl 157 9 protein protein NN cord-007714-n3omlvfl 157 10 components component NNS cord-007714-n3omlvfl 157 11 of of IN cord-007714-n3omlvfl 157 12 the the DT cord-007714-n3omlvfl 157 13 mature mature JJ cord-007714-n3omlvfl 157 14 cytoplasmic cytoplasmic JJ cord-007714-n3omlvfl 157 15 SRP SRP NNP cord-007714-n3omlvfl 157 16 ( ( -LRB- cord-007714-n3omlvfl 157 17 SRP19 SRP19 NNP cord-007714-n3omlvfl 157 18 , , , cord-007714-n3omlvfl 157 19 SRP68 SRP68 NNP cord-007714-n3omlvfl 157 20 and and CC cord-007714-n3omlvfl 157 21 SRP72 SRP72 NNPS cord-007714-n3omlvfl 157 22 but but CC cord-007714-n3omlvfl 157 23 not not RB cord-007714-n3omlvfl 157 24 SRP54 SRP54 NNP cord-007714-n3omlvfl 157 25 ) ) -RRB- cord-007714-n3omlvfl 157 26 have have VBP cord-007714-n3omlvfl 157 27 been be VBN cord-007714-n3omlvfl 157 28 localised localise VBN cord-007714-n3omlvfl 157 29 to to IN cord-007714-n3omlvfl 157 30 the the DT cord-007714-n3omlvfl 157 31 nucleolus nucleolus NN cord-007714-n3omlvfl 157 32 in in IN cord-007714-n3omlvfl 157 33 vertebrates vertebrate NNS cord-007714-n3omlvfl 158 1 ( ( -LRB- cord-007714-n3omlvfl 158 2 Politz Politz NNP cord-007714-n3omlvfl 158 3 et et NNP cord-007714-n3omlvfl 158 4 al al NNP cord-007714-n3omlvfl 158 5 . . . cord-007714-n3omlvfl 158 6 2000 2000 CD cord-007714-n3omlvfl 158 7 ) ) -RRB- cord-007714-n3omlvfl 159 1 and and CC cord-007714-n3omlvfl 159 2 in in IN cord-007714-n3omlvfl 159 3 yeast yeast NN cord-007714-n3omlvfl 159 4 ( ( -LRB- cord-007714-n3omlvfl 159 5 Grosshans Grosshans NNPS cord-007714-n3omlvfl 159 6 et et NNP cord-007714-n3omlvfl 159 7 al al NNP cord-007714-n3omlvfl 159 8 . . NNP cord-007714-n3omlvfl 159 9 2001 2001 CD cord-007714-n3omlvfl 159 10 ) ) -RRB- cord-007714-n3omlvfl 159 11 . . . cord-007714-n3omlvfl 160 1 SRP SRP NNP cord-007714-n3omlvfl 160 2 RNA RNA NNP cord-007714-n3omlvfl 160 3 injected inject VBD cord-007714-n3omlvfl 160 4 into into IN cord-007714-n3omlvfl 160 5 mammalian mammalian JJ cord-007714-n3omlvfl 160 6 cultured cultured JJ cord-007714-n3omlvfl 160 7 cells cell NNS cord-007714-n3omlvfl 160 8 rapidly rapidly RB cord-007714-n3omlvfl 160 9 localised localised JJ cord-007714-n3omlvfl 160 10 to to IN cord-007714-n3omlvfl 160 11 the the DT cord-007714-n3omlvfl 160 12 nucleolus nucleolus NN cord-007714-n3omlvfl 160 13 and and CC cord-007714-n3omlvfl 160 14 then then RB cord-007714-n3omlvfl 160 15 gradually gradually RB cord-007714-n3omlvfl 160 16 relocated relocate VBD cord-007714-n3omlvfl 160 17 to to IN cord-007714-n3omlvfl 160 18 the the DT cord-007714-n3omlvfl 160 19 cytoplasm cytoplasm NN cord-007714-n3omlvfl 160 20 , , , cord-007714-n3omlvfl 160 21 suggesting suggest VBG cord-007714-n3omlvfl 160 22 that that IN cord-007714-n3omlvfl 160 23 SRP SRP NNP cord-007714-n3omlvfl 160 24 was be VBD cord-007714-n3omlvfl 160 25 being be VBG cord-007714-n3omlvfl 160 26 assembled assemble VBN cord-007714-n3omlvfl 160 27 in in IN cord-007714-n3omlvfl 160 28 the the DT cord-007714-n3omlvfl 160 29 nucleolus nucleolus NN cord-007714-n3omlvfl 160 30 and and CC cord-007714-n3omlvfl 160 31 then then RB cord-007714-n3omlvfl 160 32 exported export VBN cord-007714-n3omlvfl 160 33 ( ( -LRB- cord-007714-n3omlvfl 160 34 Jacobsen Jacobsen NNP cord-007714-n3omlvfl 160 35 and and CC cord-007714-n3omlvfl 160 36 Pederson Pederson NNP cord-007714-n3omlvfl 160 37 1998 1998 CD cord-007714-n3omlvfl 160 38 ) ) -RRB- cord-007714-n3omlvfl 160 39 . . . cord-007714-n3omlvfl 161 1 Thus thus RB cord-007714-n3omlvfl 161 2 the the DT cord-007714-n3omlvfl 161 3 assembly assembly NN cord-007714-n3omlvfl 161 4 of of IN cord-007714-n3omlvfl 161 5 the the DT cord-007714-n3omlvfl 161 6 SRP SRP NNP cord-007714-n3omlvfl 161 7 has have VBZ cord-007714-n3omlvfl 161 8 a a DT cord-007714-n3omlvfl 161 9 nucleolar nucleolar JJ cord-007714-n3omlvfl 161 10 phase phase NN cord-007714-n3omlvfl 161 11 , , , cord-007714-n3omlvfl 161 12 but but CC cord-007714-n3omlvfl 161 13 must must MD cord-007714-n3omlvfl 161 14 be be VB cord-007714-n3omlvfl 161 15 completed complete VBN cord-007714-n3omlvfl 161 16 in in IN cord-007714-n3omlvfl 161 17 the the DT cord-007714-n3omlvfl 161 18 cytoplasm cytoplasm NN cord-007714-n3omlvfl 161 19 . . . cord-007714-n3omlvfl 162 1 Precursor precursor NN cord-007714-n3omlvfl 162 2 tRNAs trna NNS cord-007714-n3omlvfl 162 3 have have VBP cord-007714-n3omlvfl 162 4 been be VBN cord-007714-n3omlvfl 162 5 detected detect VBN cord-007714-n3omlvfl 162 6 in in IN cord-007714-n3omlvfl 162 7 the the DT cord-007714-n3omlvfl 162 8 nucleolus nucleolus NN cord-007714-n3omlvfl 162 9 by by IN cord-007714-n3omlvfl 162 10 in in IN cord-007714-n3omlvfl 162 11 situ situ NN cord-007714-n3omlvfl 162 12 hybridisation hybridisation NN cord-007714-n3omlvfl 162 13 ( ( -LRB- cord-007714-n3omlvfl 162 14 Bertrand Bertrand NNP cord-007714-n3omlvfl 162 15 et et NNP cord-007714-n3omlvfl 162 16 al al NNP cord-007714-n3omlvfl 162 17 . . NNP cord-007714-n3omlvfl 162 18 1998 1998 CD cord-007714-n3omlvfl 162 19 ) ) -RRB- cord-007714-n3omlvfl 162 20 . . . cord-007714-n3omlvfl 163 1 Pre Pre NNS cord-007714-n3omlvfl 163 2 - - NNS cord-007714-n3omlvfl 163 3 tRNAs trna NNS cord-007714-n3omlvfl 163 4 are be VBP cord-007714-n3omlvfl 163 5 trimmed trim VBN cord-007714-n3omlvfl 163 6 at at IN cord-007714-n3omlvfl 163 7 5′ 5′ CD cord-007714-n3omlvfl 163 8 and and CC cord-007714-n3omlvfl 163 9 3′ 3′ CD cord-007714-n3omlvfl 163 10 ends end NNS cord-007714-n3omlvfl 163 11 and and CC cord-007714-n3omlvfl 163 12 undergo undergo VB cord-007714-n3omlvfl 163 13 base base NN cord-007714-n3omlvfl 163 14 modifications modification NNS cord-007714-n3omlvfl 163 15 such such JJ cord-007714-n3omlvfl 163 16 as as IN cord-007714-n3omlvfl 163 17 pseudouridylation pseudouridylation NN cord-007714-n3omlvfl 163 18 and and CC cord-007714-n3omlvfl 163 19 3′ 3′ CD cord-007714-n3omlvfl 163 20 end end NN cord-007714-n3omlvfl 163 21 processing processing NN cord-007714-n3omlvfl 163 22 ( ( -LRB- cord-007714-n3omlvfl 163 23 Hopper Hopper NNP cord-007714-n3omlvfl 163 24 and and CC cord-007714-n3omlvfl 163 25 Phizicky Phizicky NNP cord-007714-n3omlvfl 163 26 2003 2003 CD cord-007714-n3omlvfl 163 27 ) ) -RRB- cord-007714-n3omlvfl 163 28 . . . cord-007714-n3omlvfl 164 1 The the DT cord-007714-n3omlvfl 164 2 5′ 5′ CD cord-007714-n3omlvfl 164 3 trimming trimming NN cord-007714-n3omlvfl 164 4 of of IN cord-007714-n3omlvfl 164 5 pre pre JJ cord-007714-n3omlvfl 164 6 - - NNS cord-007714-n3omlvfl 164 7 tRNAs tRNAs NNPS cord-007714-n3omlvfl 164 8 is be VBZ cord-007714-n3omlvfl 164 9 catalysed catalyse VBN cord-007714-n3omlvfl 164 10 by by IN cord-007714-n3omlvfl 164 11 RNase RNase NNP cord-007714-n3omlvfl 164 12 P P NNP cord-007714-n3omlvfl 164 13 and and CC cord-007714-n3omlvfl 164 14 both both CC cord-007714-n3omlvfl 164 15 protein protein NN cord-007714-n3omlvfl 164 16 and and CC cord-007714-n3omlvfl 164 17 RNA RNA NNP cord-007714-n3omlvfl 164 18 components component NNS cord-007714-n3omlvfl 164 19 of of IN cord-007714-n3omlvfl 164 20 this this DT cord-007714-n3omlvfl 164 21 RNP RNP NNP cord-007714-n3omlvfl 164 22 have have VBP cord-007714-n3omlvfl 164 23 been be VBN cord-007714-n3omlvfl 164 24 localised localise VBN cord-007714-n3omlvfl 164 25 to to IN cord-007714-n3omlvfl 164 26 the the DT cord-007714-n3omlvfl 164 27 nucleolus nucleolus NN cord-007714-n3omlvfl 164 28 ( ( -LRB- cord-007714-n3omlvfl 164 29 Jacobson Jacobson NNP cord-007714-n3omlvfl 164 30 et et NNP cord-007714-n3omlvfl 164 31 al al NNP cord-007714-n3omlvfl 164 32 . . . cord-007714-n3omlvfl 164 33 1997 1997 CD cord-007714-n3omlvfl 164 34 ; ; : cord-007714-n3omlvfl 164 35 Jarrous Jarrous NNP cord-007714-n3omlvfl 164 36 et et NNP cord-007714-n3omlvfl 164 37 al al NNP cord-007714-n3omlvfl 164 38 . . . cord-007714-n3omlvfl 164 39 1999 1999 CD cord-007714-n3omlvfl 164 40 ) ) -RRB- cord-007714-n3omlvfl 164 41 , , , cord-007714-n3omlvfl 164 42 as as IN cord-007714-n3omlvfl 164 43 has have VBZ cord-007714-n3omlvfl 164 44 Cbf5p Cbf5p NNP cord-007714-n3omlvfl 164 45 / / SYM cord-007714-n3omlvfl 164 46 Dyskerin Dyskerin NNP cord-007714-n3omlvfl 164 47 which which WDT cord-007714-n3omlvfl 164 48 catalyses catalyse VBZ cord-007714-n3omlvfl 164 49 these these DT cord-007714-n3omlvfl 164 50 and and CC cord-007714-n3omlvfl 164 51 other other JJ cord-007714-n3omlvfl 164 52 pseudouridylations pseudouridylation NNS cord-007714-n3omlvfl 164 53 . . . cord-007714-n3omlvfl 165 1 The the DT cord-007714-n3omlvfl 165 2 presence presence NN cord-007714-n3omlvfl 165 3 of of IN cord-007714-n3omlvfl 165 4 components component NNS cord-007714-n3omlvfl 165 5 of of IN cord-007714-n3omlvfl 165 6 the the DT cord-007714-n3omlvfl 165 7 RNase RNase NNP cord-007714-n3omlvfl 165 8 P P NNP cord-007714-n3omlvfl 165 9 RNP RNP NNP cord-007714-n3omlvfl 165 10 also also RB cord-007714-n3omlvfl 165 11 suggests suggest VBZ cord-007714-n3omlvfl 165 12 that that IN cord-007714-n3omlvfl 165 13 the the DT cord-007714-n3omlvfl 165 14 assembly assembly NN cord-007714-n3omlvfl 165 15 of of IN cord-007714-n3omlvfl 165 16 this this DT cord-007714-n3omlvfl 165 17 RNP RNP NNP cord-007714-n3omlvfl 165 18 could could MD cord-007714-n3omlvfl 165 19 occur occur VB cord-007714-n3omlvfl 165 20 in in IN cord-007714-n3omlvfl 165 21 the the DT cord-007714-n3omlvfl 165 22 nucleolus nucleolus NN cord-007714-n3omlvfl 165 23 . . . cord-007714-n3omlvfl 166 1 It -PRON- PRP cord-007714-n3omlvfl 166 2 has have VBZ cord-007714-n3omlvfl 166 3 been be VBN cord-007714-n3omlvfl 166 4 shown show VBN cord-007714-n3omlvfl 166 5 that that IN cord-007714-n3omlvfl 166 6 most most JJS cord-007714-n3omlvfl 166 7 tRNAs trna NNS cord-007714-n3omlvfl 166 8 in in IN cord-007714-n3omlvfl 166 9 S. S. NNP cord-007714-n3omlvfl 166 10 cerevisiae cerevisiae NNS cord-007714-n3omlvfl 166 11 are be VBP cord-007714-n3omlvfl 166 12 exported export VBN cord-007714-n3omlvfl 166 13 from from IN cord-007714-n3omlvfl 166 14 the the DT cord-007714-n3omlvfl 166 15 nucleus nucleus NN cord-007714-n3omlvfl 166 16 as as IN cord-007714-n3omlvfl 166 17 aminoacyl aminoacyl NNP cord-007714-n3omlvfl 166 18 tRNAs trna NNS cord-007714-n3omlvfl 166 19 and and CC cord-007714-n3omlvfl 166 20 that that IN cord-007714-n3omlvfl 166 21 , , , cord-007714-n3omlvfl 166 22 in in IN cord-007714-n3omlvfl 166 23 mutants mutant NNS cord-007714-n3omlvfl 166 24 defective defective JJ cord-007714-n3omlvfl 166 25 in in IN cord-007714-n3omlvfl 166 26 aminoacylation aminoacylation NN cord-007714-n3omlvfl 166 27 of of IN cord-007714-n3omlvfl 166 28 tRNA trna NN cord-007714-n3omlvfl 166 29 , , , cord-007714-n3omlvfl 166 30 tRNAs trna NNS cord-007714-n3omlvfl 166 31 accumulate accumulate VBP cord-007714-n3omlvfl 166 32 in in IN cord-007714-n3omlvfl 166 33 the the DT cord-007714-n3omlvfl 166 34 nucleolus nucleolus NN cord-007714-n3omlvfl 166 35 ( ( -LRB- cord-007714-n3omlvfl 166 36 Steiner Steiner NNP cord-007714-n3omlvfl 166 37 - - HYPH cord-007714-n3omlvfl 166 38 Mosonyi Mosonyi NNP cord-007714-n3omlvfl 166 39 and and CC cord-007714-n3omlvfl 166 40 Mangroo Mangroo NNP cord-007714-n3omlvfl 166 41 2004 2004 CD cord-007714-n3omlvfl 166 42 ) ) -RRB- cord-007714-n3omlvfl 166 43 , , , cord-007714-n3omlvfl 166 44 suggesting suggest VBG cord-007714-n3omlvfl 166 45 that that IN cord-007714-n3omlvfl 166 46 the the DT cord-007714-n3omlvfl 166 47 machinery machinery NN cord-007714-n3omlvfl 166 48 for for IN cord-007714-n3omlvfl 166 49 aminoacylation aminoacylation NN cord-007714-n3omlvfl 166 50 is be VBZ cord-007714-n3omlvfl 166 51 also also RB cord-007714-n3omlvfl 166 52 present present JJ cord-007714-n3omlvfl 166 53 in in IN cord-007714-n3omlvfl 166 54 the the DT cord-007714-n3omlvfl 166 55 nucleolus nucleolus NN cord-007714-n3omlvfl 166 56 . . . cord-007714-n3omlvfl 166 57 _SP cord-007714-n3omlvfl 167 1 Chromosome chromosome NN cord-007714-n3omlvfl 167 2 replication replication NN cord-007714-n3omlvfl 167 3 in in IN cord-007714-n3omlvfl 167 4 eukaryotes eukaryote NNS cord-007714-n3omlvfl 167 5 requires require VBZ cord-007714-n3omlvfl 167 6 the the DT cord-007714-n3omlvfl 167 7 addition addition NN cord-007714-n3omlvfl 167 8 of of IN cord-007714-n3omlvfl 167 9 multiple multiple JJ cord-007714-n3omlvfl 167 10 tandem tandem NN cord-007714-n3omlvfl 167 11 repeats repeat NNS cord-007714-n3omlvfl 167 12 of of IN cord-007714-n3omlvfl 167 13 a a DT cord-007714-n3omlvfl 167 14 short short JJ cord-007714-n3omlvfl 167 15 sequence sequence NN cord-007714-n3omlvfl 167 16 at at IN cord-007714-n3omlvfl 167 17 the the DT cord-007714-n3omlvfl 167 18 ends end NNS cord-007714-n3omlvfl 167 19 of of IN cord-007714-n3omlvfl 167 20 each each DT cord-007714-n3omlvfl 167 21 chromosome chromosome NN cord-007714-n3omlvfl 167 22 ( ( -LRB- cord-007714-n3omlvfl 167 23 TTAGGG TTAGGG NNP cord-007714-n3omlvfl 167 24 in in IN cord-007714-n3omlvfl 167 25 humans human NNS cord-007714-n3omlvfl 167 26 ) ) -RRB- cord-007714-n3omlvfl 167 27 . . . cord-007714-n3omlvfl 168 1 This this DT cord-007714-n3omlvfl 168 2 is be VBZ cord-007714-n3omlvfl 168 3 catalysed catalyse VBN cord-007714-n3omlvfl 168 4 by by IN cord-007714-n3omlvfl 168 5 a a DT cord-007714-n3omlvfl 168 6 reverse reverse JJ cord-007714-n3omlvfl 168 7 transcriptase transcriptase NN cord-007714-n3omlvfl 168 8 ( ( -LRB- cord-007714-n3omlvfl 168 9 TERT TERT NNP cord-007714-n3omlvfl 168 10 ) ) -RRB- cord-007714-n3omlvfl 168 11 , , , cord-007714-n3omlvfl 168 12 which which WDT cord-007714-n3omlvfl 168 13 copies copy VBZ cord-007714-n3omlvfl 168 14 the the DT cord-007714-n3omlvfl 168 15 repeated repeat VBN cord-007714-n3omlvfl 168 16 sequence sequence NN cord-007714-n3omlvfl 168 17 from from IN cord-007714-n3omlvfl 168 18 an an DT cord-007714-n3omlvfl 168 19 associated associate VBN cord-007714-n3omlvfl 168 20 RNA RNA NNP cord-007714-n3omlvfl 168 21 ( ( -LRB- cord-007714-n3omlvfl 168 22 TERC TERC NNP cord-007714-n3omlvfl 168 23 ) ) -RRB- cord-007714-n3omlvfl 168 24 ( ( -LRB- cord-007714-n3omlvfl 168 25 Cech Cech NNP cord-007714-n3omlvfl 168 26 2004 2004 CD cord-007714-n3omlvfl 168 27 ) ) -RRB- cord-007714-n3omlvfl 168 28 . . . cord-007714-n3omlvfl 169 1 Most Most JJS cord-007714-n3omlvfl 169 2 somatic somatic JJ cord-007714-n3omlvfl 169 3 cells cell NNS cord-007714-n3omlvfl 169 4 do do VBP cord-007714-n3omlvfl 169 5 not not RB cord-007714-n3omlvfl 169 6 have have VB cord-007714-n3omlvfl 169 7 active active JJ cord-007714-n3omlvfl 169 8 telomerase telomerase NN cord-007714-n3omlvfl 169 9 , , , cord-007714-n3omlvfl 169 10 which which WDT cord-007714-n3omlvfl 169 11 is be VBZ cord-007714-n3omlvfl 169 12 proposed propose VBN cord-007714-n3omlvfl 169 13 to to TO cord-007714-n3omlvfl 169 14 limit limit VB cord-007714-n3omlvfl 169 15 the the DT cord-007714-n3omlvfl 169 16 number number NN cord-007714-n3omlvfl 169 17 of of IN cord-007714-n3omlvfl 169 18 rounds round NNS cord-007714-n3omlvfl 169 19 of of IN cord-007714-n3omlvfl 169 20 cell cell NN cord-007714-n3omlvfl 169 21 division division NN cord-007714-n3omlvfl 169 22 that that IN cord-007714-n3omlvfl 169 23 they -PRON- PRP cord-007714-n3omlvfl 169 24 can can MD cord-007714-n3omlvfl 169 25 support support VB cord-007714-n3omlvfl 169 26 and and CC cord-007714-n3omlvfl 169 27 has have VBZ cord-007714-n3omlvfl 169 28 been be VBN cord-007714-n3omlvfl 169 29 suggested suggest VBN cord-007714-n3omlvfl 169 30 to to TO cord-007714-n3omlvfl 169 31 be be VB cord-007714-n3omlvfl 169 32 a a DT cord-007714-n3omlvfl 169 33 factor factor NN cord-007714-n3omlvfl 169 34 in in IN cord-007714-n3omlvfl 169 35 aging aging NN cord-007714-n3omlvfl 169 36 and and CC cord-007714-n3omlvfl 169 37 carcinogenesis carcinogenesis NN cord-007714-n3omlvfl 169 38 ( ( -LRB- cord-007714-n3omlvfl 169 39 Maser Maser NNP cord-007714-n3omlvfl 169 40 and and CC cord-007714-n3omlvfl 169 41 DePinho DePinho NNP cord-007714-n3omlvfl 169 42 2002 2002 CD cord-007714-n3omlvfl 169 43 ) ) -RRB- cord-007714-n3omlvfl 169 44 . . . cord-007714-n3omlvfl 170 1 The the DT cord-007714-n3omlvfl 170 2 localisation localisation NN cord-007714-n3omlvfl 170 3 of of IN cord-007714-n3omlvfl 170 4 the the DT cord-007714-n3omlvfl 170 5 RNA RNA NNP cord-007714-n3omlvfl 170 6 and and CC cord-007714-n3omlvfl 170 7 the the DT cord-007714-n3omlvfl 170 8 reverse reverse JJ cord-007714-n3omlvfl 170 9 transcriptase transcriptase NN cord-007714-n3omlvfl 170 10 catalytic catalytic JJ cord-007714-n3omlvfl 170 11 subunit subunit NN cord-007714-n3omlvfl 170 12 of of IN cord-007714-n3omlvfl 170 13 human human JJ cord-007714-n3omlvfl 170 14 telomerase telomerase NN cord-007714-n3omlvfl 170 15 , , , cord-007714-n3omlvfl 170 16 hTERT htert JJ cord-007714-n3omlvfl 170 17 , , , cord-007714-n3omlvfl 170 18 suggests suggest VBZ cord-007714-n3omlvfl 170 19 that that IN cord-007714-n3omlvfl 170 20 the the DT cord-007714-n3omlvfl 170 21 telomerase telomerase NN cord-007714-n3omlvfl 170 22 RNP RNP NNP cord-007714-n3omlvfl 170 23 may may MD cord-007714-n3omlvfl 170 24 be be VB cord-007714-n3omlvfl 170 25 assembled assemble VBN cord-007714-n3omlvfl 170 26 in in IN cord-007714-n3omlvfl 170 27 the the DT cord-007714-n3omlvfl 170 28 nucleolus nucleolus NN cord-007714-n3omlvfl 170 29 ( ( -LRB- cord-007714-n3omlvfl 170 30 Mitchell Mitchell NNP cord-007714-n3omlvfl 170 31 and and CC cord-007714-n3omlvfl 170 32 Collins Collins NNP cord-007714-n3omlvfl 170 33 2000 2000 CD cord-007714-n3omlvfl 170 34 ; ; : cord-007714-n3omlvfl 170 35 Etheridge Etheridge NNP cord-007714-n3omlvfl 170 36 et et NNP cord-007714-n3omlvfl 170 37 al al NNP cord-007714-n3omlvfl 170 38 . . . cord-007714-n3omlvfl 170 39 2002 2002 CD cord-007714-n3omlvfl 170 40 ) ) -RRB- cord-007714-n3omlvfl 170 41 . . . cord-007714-n3omlvfl 171 1 Telomerase Telomerase NNP cord-007714-n3omlvfl 171 2 RNA RNA NNP cord-007714-n3omlvfl 171 3 contains contain VBZ cord-007714-n3omlvfl 171 4 a a DT cord-007714-n3omlvfl 171 5 box box NN cord-007714-n3omlvfl 171 6 H H NNP cord-007714-n3omlvfl 171 7 / / SYM cord-007714-n3omlvfl 171 8 ACA ACA NNP cord-007714-n3omlvfl 171 9 domain domain NN cord-007714-n3omlvfl 171 10 and and CC cord-007714-n3omlvfl 171 11 a a DT cord-007714-n3omlvfl 171 12 CB CB NNP cord-007714-n3omlvfl 171 13 localisation localisation NN cord-007714-n3omlvfl 171 14 signal signal NN cord-007714-n3omlvfl 171 15 allowing allow VBG cord-007714-n3omlvfl 171 16 the the DT cord-007714-n3omlvfl 171 17 telomerase telomerase NN cord-007714-n3omlvfl 171 18 RNP RNP NNP cord-007714-n3omlvfl 171 19 to to TO cord-007714-n3omlvfl 171 20 localise localise VB cord-007714-n3omlvfl 171 21 to to IN cord-007714-n3omlvfl 171 22 both both DT cord-007714-n3omlvfl 171 23 CBs CBs NNP cord-007714-n3omlvfl 171 24 and and CC cord-007714-n3omlvfl 171 25 the the DT cord-007714-n3omlvfl 171 26 nucleolus nucleolus NN cord-007714-n3omlvfl 171 27 in in IN cord-007714-n3omlvfl 171 28 its -PRON- PRP$ cord-007714-n3omlvfl 171 29 maturation maturation NN cord-007714-n3omlvfl 171 30 ( ( -LRB- cord-007714-n3omlvfl 171 31 Mitchell Mitchell NNP cord-007714-n3omlvfl 171 32 et et NNP cord-007714-n3omlvfl 171 33 al al NNP cord-007714-n3omlvfl 171 34 . . . cord-007714-n3omlvfl 172 1 1999 1999 CD cord-007714-n3omlvfl 172 2 ; ; : cord-007714-n3omlvfl 172 3 Lukowiak Lukowiak NNP cord-007714-n3omlvfl 172 4 et et NNP cord-007714-n3omlvfl 172 5 al al NNP cord-007714-n3omlvfl 172 6 . . . cord-007714-n3omlvfl 173 1 2001 2001 CD cord-007714-n3omlvfl 173 2 ; ; : cord-007714-n3omlvfl 173 3 Jady Jady NNP cord-007714-n3omlvfl 173 4 et et NNP cord-007714-n3omlvfl 173 5 al al NNP cord-007714-n3omlvfl 173 6 . . . cord-007714-n3omlvfl 173 7 2004 2004 CD cord-007714-n3omlvfl 173 8 ) ) -RRB- cord-007714-n3omlvfl 173 9 . . . cord-007714-n3omlvfl 174 1 The the DT cord-007714-n3omlvfl 174 2 localisation localisation NN cord-007714-n3omlvfl 174 3 of of IN cord-007714-n3omlvfl 174 4 telomerase telomerase NN cord-007714-n3omlvfl 174 5 in in IN cord-007714-n3omlvfl 174 6 the the DT cord-007714-n3omlvfl 174 7 nucleolus nucleolus NN cord-007714-n3omlvfl 174 8 may may MD cord-007714-n3omlvfl 174 9 reflect reflect VB cord-007714-n3omlvfl 174 10 its -PRON- PRP$ cord-007714-n3omlvfl 174 11 assembly assembly NN cord-007714-n3omlvfl 174 12 pathway pathway NN cord-007714-n3omlvfl 174 13 and/or and/or CC cord-007714-n3omlvfl 174 14 its -PRON- PRP$ cord-007714-n3omlvfl 174 15 sequestration sequestration NN cord-007714-n3omlvfl 174 16 as as IN cord-007714-n3omlvfl 174 17 part part NN cord-007714-n3omlvfl 174 18 of of IN cord-007714-n3omlvfl 174 19 the the DT cord-007714-n3omlvfl 174 20 regulation regulation NN cord-007714-n3omlvfl 174 21 of of IN cord-007714-n3omlvfl 174 22 its -PRON- PRP$ cord-007714-n3omlvfl 174 23 activity activity NN cord-007714-n3omlvfl 174 24 . . . cord-007714-n3omlvfl 175 1 Telomerase telomerase NN cord-007714-n3omlvfl 175 2 resides reside VBZ cord-007714-n3omlvfl 175 3 in in IN cord-007714-n3omlvfl 175 4 the the DT cord-007714-n3omlvfl 175 5 nucleolus nucleolus NN cord-007714-n3omlvfl 175 6 but but CC cord-007714-n3omlvfl 175 7 is be VBZ cord-007714-n3omlvfl 175 8 specifically specifically RB cord-007714-n3omlvfl 175 9 redistributed redistribute VBN cord-007714-n3omlvfl 175 10 in in IN cord-007714-n3omlvfl 175 11 late late JJ cord-007714-n3omlvfl 175 12 S s NN cord-007714-n3omlvfl 175 13 - - HYPH cord-007714-n3omlvfl 175 14 phase phase NN cord-007714-n3omlvfl 175 15 , , , cord-007714-n3omlvfl 175 16 when when WRB cord-007714-n3omlvfl 175 17 telomere telomere NN cord-007714-n3omlvfl 175 18 replication replication NN cord-007714-n3omlvfl 175 19 takes take VBZ cord-007714-n3omlvfl 175 20 place place NN cord-007714-n3omlvfl 175 21 , , , cord-007714-n3omlvfl 175 22 thereby thereby RB cord-007714-n3omlvfl 175 23 avoiding avoid VBG cord-007714-n3omlvfl 175 24 inappropriate inappropriate JJ cord-007714-n3omlvfl 175 25 expression expression NN cord-007714-n3omlvfl 175 26 throughout throughout IN cord-007714-n3omlvfl 175 27 the the DT cord-007714-n3omlvfl 175 28 nucleus nucleus NN cord-007714-n3omlvfl 175 29 which which WDT cord-007714-n3omlvfl 175 30 could could MD cord-007714-n3omlvfl 175 31 cause cause VB cord-007714-n3omlvfl 175 32 new new JJ cord-007714-n3omlvfl 175 33 telomeric telomeric JJ cord-007714-n3omlvfl 175 34 structures structure NNS cord-007714-n3omlvfl 175 35 to to TO cord-007714-n3omlvfl 175 36 be be VB cord-007714-n3omlvfl 175 37 nucleated nucleate VBN cord-007714-n3omlvfl 175 38 on on IN cord-007714-n3omlvfl 175 39 replication replication NN cord-007714-n3omlvfl 175 40 intermediates intermediate NNS cord-007714-n3omlvfl 175 41 or or CC cord-007714-n3omlvfl 175 42 double double JJ cord-007714-n3omlvfl 175 43 strand strand NN cord-007714-n3omlvfl 175 44 breaks break NNS cord-007714-n3omlvfl 176 1 ( ( -LRB- cord-007714-n3omlvfl 176 2 Wong Wong NNP cord-007714-n3omlvfl 176 3 et et NNP cord-007714-n3omlvfl 176 4 al al NNP cord-007714-n3omlvfl 176 5 . . . cord-007714-n3omlvfl 176 6 2002 2002 CD cord-007714-n3omlvfl 176 7 ) ) -RRB- cord-007714-n3omlvfl 176 8 . . . cord-007714-n3omlvfl 177 1 Small small JJ cord-007714-n3omlvfl 177 2 nuclear nuclear JJ cord-007714-n3omlvfl 177 3 RNAs rna NNS cord-007714-n3omlvfl 177 4 ( ( -LRB- cord-007714-n3omlvfl 177 5 snRNAs snRNAs NNP cord-007714-n3omlvfl 177 6 ) ) -RRB- cord-007714-n3omlvfl 177 7 are be VBP cord-007714-n3omlvfl 177 8 involved involve VBN cord-007714-n3omlvfl 177 9 in in IN cord-007714-n3omlvfl 177 10 splicing splicing NN cord-007714-n3omlvfl 177 11 and and CC cord-007714-n3omlvfl 177 12 form form VB cord-007714-n3omlvfl 177 13 the the DT cord-007714-n3omlvfl 177 14 cores core NNS cord-007714-n3omlvfl 177 15 of of IN cord-007714-n3omlvfl 177 16 the the DT cord-007714-n3omlvfl 177 17 spliceosomal spliceosomal JJ cord-007714-n3omlvfl 177 18 complexes complex NNS cord-007714-n3omlvfl 177 19 . . . cord-007714-n3omlvfl 178 1 There there EX cord-007714-n3omlvfl 178 2 is be VBZ cord-007714-n3omlvfl 178 3 good good JJ cord-007714-n3omlvfl 178 4 evidence evidence NN cord-007714-n3omlvfl 178 5 that that IN cord-007714-n3omlvfl 178 6 U4 U4 NNP cord-007714-n3omlvfl 178 7 / / SYM cord-007714-n3omlvfl 178 8 U6.U5 U6.U5 NNP cord-007714-n3omlvfl 178 9 and and CC cord-007714-n3omlvfl 178 10 U2 U2 NNP cord-007714-n3omlvfl 178 11 snRNAs snRNAs NNP cord-007714-n3omlvfl 178 12 are be VBP cord-007714-n3omlvfl 178 13 also also RB cord-007714-n3omlvfl 178 14 in in IN cord-007714-n3omlvfl 178 15 the the DT cord-007714-n3omlvfl 178 16 nucleolus nucleolus NN cord-007714-n3omlvfl 178 17 and and CC cord-007714-n3omlvfl 178 18 undergo undergo VBP cord-007714-n3omlvfl 178 19 part part NN cord-007714-n3omlvfl 178 20 of of IN cord-007714-n3omlvfl 178 21 their -PRON- PRP$ cord-007714-n3omlvfl 178 22 maturation maturation NN cord-007714-n3omlvfl 178 23 or or CC cord-007714-n3omlvfl 178 24 assembly assembly NN cord-007714-n3omlvfl 178 25 processing processing NN cord-007714-n3omlvfl 178 26 there there RB cord-007714-n3omlvfl 178 27 , , , cord-007714-n3omlvfl 178 28 and and CC cord-007714-n3omlvfl 178 29 that that IN cord-007714-n3omlvfl 178 30 the the DT cord-007714-n3omlvfl 178 31 individual individual JJ cord-007714-n3omlvfl 178 32 snRNAs snrna NNS cord-007714-n3omlvfl 178 33 are be VBP cord-007714-n3omlvfl 178 34 transported transport VBN cord-007714-n3omlvfl 178 35 independently independently RB cord-007714-n3omlvfl 178 36 to to IN cord-007714-n3omlvfl 178 37 the the DT cord-007714-n3omlvfl 178 38 nucleolus nucleolus NN cord-007714-n3omlvfl 178 39 ( ( -LRB- cord-007714-n3omlvfl 178 40 Lange Lange NNP cord-007714-n3omlvfl 178 41 and and CC cord-007714-n3omlvfl 178 42 Gerbi Gerbi NNP cord-007714-n3omlvfl 178 43 2000 2000 CD cord-007714-n3omlvfl 178 44 ; ; : cord-007714-n3omlvfl 178 45 Yu Yu NNP cord-007714-n3omlvfl 178 46 et et NNP cord-007714-n3omlvfl 178 47 al al NNP cord-007714-n3omlvfl 178 48 . . . cord-007714-n3omlvfl 179 1 2001 2001 CD cord-007714-n3omlvfl 179 2 ; ; : cord-007714-n3omlvfl 179 3 Gerbi Gerbi NNP cord-007714-n3omlvfl 179 4 and and CC cord-007714-n3omlvfl 179 5 Lange Lange NNP cord-007714-n3omlvfl 179 6 2002 2002 CD cord-007714-n3omlvfl 179 7 ) ) -RRB- cord-007714-n3omlvfl 179 8 . . . cord-007714-n3omlvfl 180 1 A a DT cord-007714-n3omlvfl 180 2 nucleolar nucleolar JJ cord-007714-n3omlvfl 180 3 phase phase NN cord-007714-n3omlvfl 180 4 for for IN cord-007714-n3omlvfl 180 5 snRNPs snRNPs NNP cord-007714-n3omlvfl 180 6 is be VBZ cord-007714-n3omlvfl 180 7 strongly strongly RB cord-007714-n3omlvfl 180 8 supported support VBN cord-007714-n3omlvfl 180 9 by by IN cord-007714-n3omlvfl 180 10 the the DT cord-007714-n3omlvfl 180 11 proteomic proteomic JJ cord-007714-n3omlvfl 180 12 analyses analysis NNS cord-007714-n3omlvfl 180 13 of of IN cord-007714-n3omlvfl 180 14 the the DT cord-007714-n3omlvfl 180 15 nucleoli nucleoli NNP cord-007714-n3omlvfl 180 16 in in IN cord-007714-n3omlvfl 180 17 both both CC cord-007714-n3omlvfl 180 18 human human JJ cord-007714-n3omlvfl 180 19 and and CC cord-007714-n3omlvfl 180 20 plant plant NN cord-007714-n3omlvfl 180 21 cells cell NNS cord-007714-n3omlvfl 180 22 ( ( -LRB- cord-007714-n3omlvfl 180 23 Andersen Andersen NNP cord-007714-n3omlvfl 180 24 et et NNP cord-007714-n3omlvfl 180 25 al al NNP cord-007714-n3omlvfl 180 26 . . . cord-007714-n3omlvfl 181 1 2002 2002 CD cord-007714-n3omlvfl 182 1 Scherl Scherl NNP cord-007714-n3omlvfl 182 2 et et NNP cord-007714-n3omlvfl 182 3 al al NNP cord-007714-n3omlvfl 182 4 . . . cord-007714-n3omlvfl 183 1 2002 2002 CD cord-007714-n3omlvfl 183 2 ; ; : cord-007714-n3omlvfl 183 3 Pendle Pendle NNP cord-007714-n3omlvfl 183 4 et et NNP cord-007714-n3omlvfl 183 5 al al NNP cord-007714-n3omlvfl 183 6 . . NNP cord-007714-n3omlvfl 183 7 2005 2005 CD cord-007714-n3omlvfl 183 8 ) ) -RRB- cord-007714-n3omlvfl 183 9 . . . cord-007714-n3omlvfl 184 1 These these DT cord-007714-n3omlvfl 184 2 studies study NNS cord-007714-n3omlvfl 184 3 showed show VBD cord-007714-n3omlvfl 184 4 the the DT cord-007714-n3omlvfl 184 5 presence presence NN cord-007714-n3omlvfl 184 6 of of IN cord-007714-n3omlvfl 184 7 many many JJ cord-007714-n3omlvfl 184 8 snRNA snrna JJ cord-007714-n3omlvfl 184 9 - - HYPH cord-007714-n3omlvfl 184 10 associated associate VBN cord-007714-n3omlvfl 184 11 proteins protein NNS cord-007714-n3omlvfl 184 12 , , , cord-007714-n3omlvfl 184 13 particularly particularly RB cord-007714-n3omlvfl 184 14 the the DT cord-007714-n3omlvfl 184 15 Sm sm NN cord-007714-n3omlvfl 184 16 class class NN cord-007714-n3omlvfl 184 17 of of IN cord-007714-n3omlvfl 184 18 proteins protein NNS cord-007714-n3omlvfl 184 19 , , , cord-007714-n3omlvfl 184 20 pointing point VBG cord-007714-n3omlvfl 184 21 to to IN cord-007714-n3omlvfl 184 22 a a DT cord-007714-n3omlvfl 184 23 role role NN cord-007714-n3omlvfl 184 24 in in IN cord-007714-n3omlvfl 184 25 the the DT cord-007714-n3omlvfl 184 26 maturation maturation NN cord-007714-n3omlvfl 184 27 of of IN cord-007714-n3omlvfl 184 28 snRNAs snrna NNS cord-007714-n3omlvfl 184 29 and and CC cord-007714-n3omlvfl 184 30 the the DT cord-007714-n3omlvfl 184 31 assembly assembly NN cord-007714-n3omlvfl 184 32 of of IN cord-007714-n3omlvfl 184 33 snRNPs snRNPs NNP cord-007714-n3omlvfl 184 34 . . . cord-007714-n3omlvfl 185 1 U6snRNA U6snRNA NNP cord-007714-n3omlvfl 185 2 differs differ VBZ cord-007714-n3omlvfl 185 3 from from IN cord-007714-n3omlvfl 185 4 the the DT cord-007714-n3omlvfl 185 5 other other JJ cord-007714-n3omlvfl 185 6 spliceosomal spliceosomal JJ cord-007714-n3omlvfl 185 7 snRNAs snrna NNS cord-007714-n3omlvfl 185 8 in in IN cord-007714-n3omlvfl 185 9 its -PRON- PRP$ cord-007714-n3omlvfl 185 10 cap cap NN cord-007714-n3omlvfl 185 11 structure structure NN cord-007714-n3omlvfl 185 12 and and CC cord-007714-n3omlvfl 185 13 maturation maturation NN cord-007714-n3omlvfl 185 14 pathway pathway NN cord-007714-n3omlvfl 185 15 . . . cord-007714-n3omlvfl 186 1 Factors factor NNS cord-007714-n3omlvfl 186 2 involved involve VBN cord-007714-n3omlvfl 186 3 in in IN cord-007714-n3omlvfl 186 4 U6 U6 NNP cord-007714-n3omlvfl 186 5 nucleotide nucleotide JJ cord-007714-n3omlvfl 186 6 modifications modification NNS cord-007714-n3omlvfl 186 7 are be VBP cord-007714-n3omlvfl 186 8 found find VBN cord-007714-n3omlvfl 186 9 in in IN cord-007714-n3omlvfl 186 10 the the DT cord-007714-n3omlvfl 186 11 nucleolus nucleolus NN cord-007714-n3omlvfl 186 12 , , , cord-007714-n3omlvfl 186 13 suggesting suggest VBG cord-007714-n3omlvfl 186 14 a a DT cord-007714-n3omlvfl 186 15 nucleolar nucleolar JJ cord-007714-n3omlvfl 186 16 phase phase NN cord-007714-n3omlvfl 186 17 for for IN cord-007714-n3omlvfl 186 18 the the DT cord-007714-n3omlvfl 186 19 production production NN cord-007714-n3omlvfl 186 20 of of IN cord-007714-n3omlvfl 186 21 mature mature JJ cord-007714-n3omlvfl 186 22 U6snRNA U6snRNA NNP cord-007714-n3omlvfl 186 23 ( ( -LRB- cord-007714-n3omlvfl 186 24 Ganot Ganot NNP cord-007714-n3omlvfl 186 25 et et NNP cord-007714-n3omlvfl 186 26 al al NNP cord-007714-n3omlvfl 186 27 . . . cord-007714-n3omlvfl 186 28 1999 1999 CD cord-007714-n3omlvfl 186 29 ) ) -RRB- cord-007714-n3omlvfl 186 30 . . . cord-007714-n3omlvfl 187 1 Plants plant NNS cord-007714-n3omlvfl 187 2 contain contain VBP cord-007714-n3omlvfl 187 3 a a DT cord-007714-n3omlvfl 187 4 novel novel JJ cord-007714-n3omlvfl 187 5 RNA rna NN cord-007714-n3omlvfl 187 6 polymerase polymerase NN cord-007714-n3omlvfl 187 7 ( ( -LRB- cord-007714-n3omlvfl 187 8 RNA RNA NNP cord-007714-n3omlvfl 187 9 polymerase polymerase NN cord-007714-n3omlvfl 187 10 IV IV NNP cord-007714-n3omlvfl 187 11 , , , cord-007714-n3omlvfl 187 12 Pol Pol NNP cord-007714-n3omlvfl 187 13 IV IV NNP cord-007714-n3omlvfl 187 14 ) ) -RRB- cord-007714-n3omlvfl 187 15 involved involve VBN cord-007714-n3omlvfl 187 16 in in IN cord-007714-n3omlvfl 187 17 production production NN cord-007714-n3omlvfl 187 18 of of IN cord-007714-n3omlvfl 187 19 transcripts transcript NNS cord-007714-n3omlvfl 187 20 which which WDT cord-007714-n3omlvfl 187 21 give give VBP cord-007714-n3omlvfl 187 22 rise rise NN cord-007714-n3omlvfl 187 23 to to IN cord-007714-n3omlvfl 187 24 double double RB cord-007714-n3omlvfl 187 25 - - HYPH cord-007714-n3omlvfl 187 26 stranded stranded JJ cord-007714-n3omlvfl 187 27 RNAs rna NNS cord-007714-n3omlvfl 187 28 and and CC cord-007714-n3omlvfl 187 29 small small JJ cord-007714-n3omlvfl 187 30 interfering interfere VBG cord-007714-n3omlvfl 187 31 RNAs rna NNS cord-007714-n3omlvfl 187 32 ( ( -LRB- cord-007714-n3omlvfl 187 33 siRNAs siRNAs NNP cord-007714-n3omlvfl 187 34 ) ) -RRB- cord-007714-n3omlvfl 187 35 which which WDT cord-007714-n3omlvfl 187 36 guide guide NN cord-007714-n3omlvfl 187 37 DNA dna NN cord-007714-n3omlvfl 187 38 methylation methylation NN cord-007714-n3omlvfl 187 39 . . . cord-007714-n3omlvfl 188 1 The the DT cord-007714-n3omlvfl 188 2 protein protein NN cord-007714-n3omlvfl 188 3 components component NNS cord-007714-n3omlvfl 188 4 required require VBN cord-007714-n3omlvfl 188 5 for for IN cord-007714-n3omlvfl 188 6 the the DT cord-007714-n3omlvfl 188 7 production production NN cord-007714-n3omlvfl 188 8 of of IN cord-007714-n3omlvfl 188 9 such such JJ cord-007714-n3omlvfl 188 10 heterochromatic heterochromatic JJ cord-007714-n3omlvfl 188 11 siRNAs sirna NNS cord-007714-n3omlvfl 188 12 include include VBP cord-007714-n3omlvfl 188 13 the the DT cord-007714-n3omlvfl 188 14 large large JJ cord-007714-n3omlvfl 188 15 subunit subunit NN cord-007714-n3omlvfl 188 16 of of IN cord-007714-n3omlvfl 188 17 Pol Pol NNP cord-007714-n3omlvfl 188 18 IV IV NNP cord-007714-n3omlvfl 188 19 ( ( -LRB- cord-007714-n3omlvfl 188 20 NRPD1b NRPD1b NNP cord-007714-n3omlvfl 188 21 ) ) -RRB- cord-007714-n3omlvfl 188 22 , , , cord-007714-n3omlvfl 188 23 AGO3 AGO3 NNP cord-007714-n3omlvfl 188 24 , , , cord-007714-n3omlvfl 188 25 DCL3 DCL3 NNP cord-007714-n3omlvfl 188 26 and and CC cord-007714-n3omlvfl 188 27 RDR2 RDR2 NNP cord-007714-n3omlvfl 188 28 . . . cord-007714-n3omlvfl 189 1 These these DT cord-007714-n3omlvfl 189 2 proteins protein NNS cord-007714-n3omlvfl 189 3 co co VBP cord-007714-n3omlvfl 189 4 - - JJ cord-007714-n3omlvfl 189 5 localised localised JJ cord-007714-n3omlvfl 189 6 with with IN cord-007714-n3omlvfl 189 7 siRNAs sirna NNS cord-007714-n3omlvfl 189 8 in in IN cord-007714-n3omlvfl 189 9 foci foci NN cord-007714-n3omlvfl 189 10 in in IN cord-007714-n3omlvfl 189 11 the the DT cord-007714-n3omlvfl 189 12 nucleolus nucleolus NN cord-007714-n3omlvfl 189 13 or or CC cord-007714-n3omlvfl 189 14 in in IN cord-007714-n3omlvfl 189 15 CBs CBs NNP cord-007714-n3omlvfl 189 16 Pontes Pontes NNPS cord-007714-n3omlvfl 189 17 et et NNP cord-007714-n3omlvfl 189 18 al al NNP cord-007714-n3omlvfl 189 19 . . . cord-007714-n3omlvfl 189 20 2006 2006 CD cord-007714-n3omlvfl 189 21 ) ) -RRB- cord-007714-n3omlvfl 189 22 . . . cord-007714-n3omlvfl 190 1 Thus thus RB cord-007714-n3omlvfl 190 2 the the DT cord-007714-n3omlvfl 190 3 nucleolus nucleolus NN cord-007714-n3omlvfl 190 4 / / SYM cord-007714-n3omlvfl 190 5 CBs CBs NNPS cord-007714-n3omlvfl 190 6 are be VBP cord-007714-n3omlvfl 190 7 involved involve VBN cord-007714-n3omlvfl 190 8 in in IN cord-007714-n3omlvfl 190 9 siRNA siRNA NNP cord-007714-n3omlvfl 190 10 production production NN cord-007714-n3omlvfl 190 11 and and CC cord-007714-n3omlvfl 190 12 assembly assembly NN cord-007714-n3omlvfl 190 13 of of IN cord-007714-n3omlvfl 190 14 silencing silence VBG cord-007714-n3omlvfl 190 15 complexes complex NNS cord-007714-n3omlvfl 190 16 . . . cord-007714-n3omlvfl 191 1 This this DT cord-007714-n3omlvfl 191 2 role role NN cord-007714-n3omlvfl 191 3 in in IN cord-007714-n3omlvfl 191 4 the the DT cord-007714-n3omlvfl 191 5 transcriptional transcriptional JJ cord-007714-n3omlvfl 191 6 gene gene NN cord-007714-n3omlvfl 191 7 silencing silence VBG cord-007714-n3omlvfl 191 8 pathway pathway NN cord-007714-n3omlvfl 191 9 in in IN cord-007714-n3omlvfl 191 10 plants plant NNS cord-007714-n3omlvfl 191 11 raises raise VBZ cord-007714-n3omlvfl 191 12 the the DT cord-007714-n3omlvfl 191 13 question question NN cord-007714-n3omlvfl 191 14 of of IN cord-007714-n3omlvfl 191 15 whether whether IN cord-007714-n3omlvfl 191 16 other other JJ cord-007714-n3omlvfl 191 17 RNA RNA NNP cord-007714-n3omlvfl 191 18 silencing silence VBG cord-007714-n3omlvfl 191 19 pathways pathway NNS cord-007714-n3omlvfl 191 20 or or CC cord-007714-n3omlvfl 191 21 the the DT cord-007714-n3omlvfl 191 22 cross cross NN cord-007714-n3omlvfl 191 23 talk talk NN cord-007714-n3omlvfl 191 24 among among IN cord-007714-n3omlvfl 191 25 pathways pathway NNS cord-007714-n3omlvfl 191 26 also also RB cord-007714-n3omlvfl 191 27 involves involve VBZ cord-007714-n3omlvfl 191 28 the the DT cord-007714-n3omlvfl 191 29 nucleolus nucleolus NN cord-007714-n3omlvfl 191 30 . . . cord-007714-n3omlvfl 192 1 The the DT cord-007714-n3omlvfl 192 2 nucleolus nucleolus NN cord-007714-n3omlvfl 192 3 has have VBZ cord-007714-n3omlvfl 192 4 previously previously RB cord-007714-n3omlvfl 192 5 been be VBN cord-007714-n3omlvfl 192 6 implicated implicate VBN cord-007714-n3omlvfl 192 7 in in IN cord-007714-n3omlvfl 192 8 mRNA mRNA NNP cord-007714-n3omlvfl 192 9 export export NN cord-007714-n3omlvfl 192 10 or or CC cord-007714-n3omlvfl 192 11 surveillance surveillance NN cord-007714-n3omlvfl 192 12 Pederson Pederson NNP cord-007714-n3omlvfl 192 13 1998 1998 CD cord-007714-n3omlvfl 192 14 ) ) -RRB- cord-007714-n3omlvfl 192 15 . . . cord-007714-n3omlvfl 193 1 In in IN cord-007714-n3omlvfl 193 2 yeast yeast NN cord-007714-n3omlvfl 193 3 , , , cord-007714-n3omlvfl 193 4 in in IN cord-007714-n3omlvfl 193 5 mRNA mRNA NNP cord-007714-n3omlvfl 193 6 transport transport NN cord-007714-n3omlvfl 193 7 - - HYPH cord-007714-n3omlvfl 193 8 defective defective JJ cord-007714-n3omlvfl 193 9 mutants mutant NNS cord-007714-n3omlvfl 193 10 and and CC cord-007714-n3omlvfl 193 11 mutants mutant NNS cord-007714-n3omlvfl 193 12 of of IN cord-007714-n3omlvfl 193 13 some some DT cord-007714-n3omlvfl 193 14 nucleolar nucleolar JJ cord-007714-n3omlvfl 193 15 proteins protein NNS cord-007714-n3omlvfl 193 16 , , , cord-007714-n3omlvfl 193 17 the the DT cord-007714-n3omlvfl 193 18 nucleolus nucleolus NN cord-007714-n3omlvfl 193 19 was be VBD cord-007714-n3omlvfl 193 20 disrupted disrupt VBN cord-007714-n3omlvfl 193 21 and and CC cord-007714-n3omlvfl 193 22 fragmented fragmented JJ cord-007714-n3omlvfl 193 23 and and CC cord-007714-n3omlvfl 193 24 accumulated accumulate VBN cord-007714-n3omlvfl 193 25 poly(A)+ poly(A)+ NNP cord-007714-n3omlvfl 193 26 RNA RNA NNP cord-007714-n3omlvfl 193 27 . . . cord-007714-n3omlvfl 194 1 Similarly similarly RB cord-007714-n3omlvfl 194 2 , , , cord-007714-n3omlvfl 194 3 in in IN cord-007714-n3omlvfl 194 4 transport transport NN cord-007714-n3omlvfl 194 5 - - HYPH cord-007714-n3omlvfl 194 6 defective defective JJ cord-007714-n3omlvfl 194 7 mutants mutant NNS cord-007714-n3omlvfl 194 8 in in IN cord-007714-n3omlvfl 194 9 Schizosaccharomyces Schizosaccharomyces NNP cord-007714-n3omlvfl 194 10 pombe pombe NN cord-007714-n3omlvfl 194 11 , , , cord-007714-n3omlvfl 194 12 an an DT cord-007714-n3omlvfl 194 13 intron intron NN cord-007714-n3omlvfl 194 14 - - HYPH cord-007714-n3omlvfl 194 15 containing contain VBG cord-007714-n3omlvfl 194 16 transcript transcript NN cord-007714-n3omlvfl 194 17 accumulated accumulate VBN cord-007714-n3omlvfl 194 18 in in IN cord-007714-n3omlvfl 194 19 the the DT cord-007714-n3omlvfl 194 20 nucleolus nucleolus NN cord-007714-n3omlvfl 194 21 , , , cord-007714-n3omlvfl 194 22 whereas whereas IN cord-007714-n3omlvfl 194 23 transcripts transcript NNS cord-007714-n3omlvfl 194 24 from from IN cord-007714-n3omlvfl 194 25 the the DT cord-007714-n3omlvfl 194 26 intronless intronless NNP cord-007714-n3omlvfl 194 27 cDNA cdna NN cord-007714-n3omlvfl 194 28 were be VBD cord-007714-n3omlvfl 194 29 exported export VBN cord-007714-n3omlvfl 195 1 ( ( -LRB- cord-007714-n3omlvfl 195 2 Ideue Ideue NNP cord-007714-n3omlvfl 195 3 et et NNP cord-007714-n3omlvfl 195 4 al al NNP cord-007714-n3omlvfl 195 5 . . . cord-007714-n3omlvfl 195 6 2004 2004 CD cord-007714-n3omlvfl 195 7 ) ) -RRB- cord-007714-n3omlvfl 195 8 . . . cord-007714-n3omlvfl 196 1 Furthermore furthermore RB cord-007714-n3omlvfl 196 2 , , , cord-007714-n3omlvfl 196 3 heat heat NN cord-007714-n3omlvfl 196 4 shock shock NN cord-007714-n3omlvfl 196 5 of of IN cord-007714-n3omlvfl 196 6 S. S. NNP cord-007714-n3omlvfl 196 7 pombe pombe NN cord-007714-n3omlvfl 196 8 cells cell NNS cord-007714-n3omlvfl 196 9 resulted result VBD cord-007714-n3omlvfl 196 10 in in IN cord-007714-n3omlvfl 196 11 accumulation accumulation NN cord-007714-n3omlvfl 196 12 of of IN cord-007714-n3omlvfl 196 13 poly(A)+ poly(A)+ NNP cord-007714-n3omlvfl 196 14 RNA RNA NNP cord-007714-n3omlvfl 196 15 in in IN cord-007714-n3omlvfl 196 16 the the DT cord-007714-n3omlvfl 196 17 nucleolus nucleolus NN cord-007714-n3omlvfl 196 18 ( ( -LRB- cord-007714-n3omlvfl 196 19 Tani Tani NNP cord-007714-n3omlvfl 196 20 et et NNP cord-007714-n3omlvfl 196 21 al al NNP cord-007714-n3omlvfl 196 22 . . NNP cord-007714-n3omlvfl 196 23 1995 1995 CD cord-007714-n3omlvfl 196 24 ) ) -RRB- cord-007714-n3omlvfl 196 25 while while IN cord-007714-n3omlvfl 196 26 ethanol ethanol NN cord-007714-n3omlvfl 196 27 stress stress NN cord-007714-n3omlvfl 196 28 caused cause VBD cord-007714-n3omlvfl 196 29 the the DT cord-007714-n3omlvfl 196 30 accumulation accumulation NN cord-007714-n3omlvfl 196 31 of of IN cord-007714-n3omlvfl 196 32 specific specific JJ cord-007714-n3omlvfl 196 33 transcripts transcript NNS cord-007714-n3omlvfl 196 34 in in IN cord-007714-n3omlvfl 196 35 the the DT cord-007714-n3omlvfl 196 36 nucleolus nucleolus NN cord-007714-n3omlvfl 196 37 ( ( -LRB- cord-007714-n3omlvfl 196 38 Brodsky Brodsky NNP cord-007714-n3omlvfl 196 39 and and CC cord-007714-n3omlvfl 196 40 Silver Silver NNP cord-007714-n3omlvfl 196 41 2000 2000 CD cord-007714-n3omlvfl 196 42 ) ) -RRB- cord-007714-n3omlvfl 196 43 . . . cord-007714-n3omlvfl 197 1 In in IN cord-007714-n3omlvfl 197 2 S. S. NNP cord-007714-n3omlvfl 197 3 pombe pombe NN cord-007714-n3omlvfl 197 4 mutants mutant NNS cord-007714-n3omlvfl 197 5 which which WDT cord-007714-n3omlvfl 197 6 undergo undergo VBP cord-007714-n3omlvfl 197 7 aberrant aberrant JJ cord-007714-n3omlvfl 197 8 cytokinesis cytokinesis NN cord-007714-n3omlvfl 197 9 generating generate VBG cord-007714-n3omlvfl 197 10 nuclei nucleus NNS cord-007714-n3omlvfl 197 11 with with IN cord-007714-n3omlvfl 197 12 and and CC cord-007714-n3omlvfl 197 13 without without IN cord-007714-n3omlvfl 197 14 a a DT cord-007714-n3omlvfl 197 15 nucleolus nucleolus NN cord-007714-n3omlvfl 197 16 , , , cord-007714-n3omlvfl 197 17 poly(A)+ poly(A)+ NNP cord-007714-n3omlvfl 197 18 accumulated accumulate VBN cord-007714-n3omlvfl 197 19 only only RB cord-007714-n3omlvfl 197 20 in in IN cord-007714-n3omlvfl 197 21 the the DT cord-007714-n3omlvfl 197 22 latter latter JJ cord-007714-n3omlvfl 197 23 , , , cord-007714-n3omlvfl 197 24 suggesting suggest VBG cord-007714-n3omlvfl 197 25 that that IN cord-007714-n3omlvfl 197 26 poly poly NNP cord-007714-n3omlvfl 197 27 A+ A+ NNP cord-007714-n3omlvfl 197 28 mRNA mRNA NNP cord-007714-n3omlvfl 197 29 associates associate NNS cord-007714-n3omlvfl 197 30 transiently transiently RB cord-007714-n3omlvfl 197 31 with with IN cord-007714-n3omlvfl 197 32 the the DT cord-007714-n3omlvfl 197 33 nucleolus nucleolus NN cord-007714-n3omlvfl 197 34 during during IN cord-007714-n3omlvfl 197 35 export export NN cord-007714-n3omlvfl 197 36 ( ( -LRB- cord-007714-n3omlvfl 197 37 Ideue Ideue NNP cord-007714-n3omlvfl 197 38 et et NNP cord-007714-n3omlvfl 197 39 al al NNP cord-007714-n3omlvfl 197 40 . . . cord-007714-n3omlvfl 197 41 2004 2004 CD cord-007714-n3omlvfl 197 42 ) ) -RRB- cord-007714-n3omlvfl 197 43 . . . cord-007714-n3omlvfl 198 1 However however RB cord-007714-n3omlvfl 198 2 , , , cord-007714-n3omlvfl 198 3 recent recent JJ cord-007714-n3omlvfl 198 4 work work NN cord-007714-n3omlvfl 198 5 on on IN cord-007714-n3omlvfl 198 6 mechanisms mechanism NNS cord-007714-n3omlvfl 198 7 of of IN cord-007714-n3omlvfl 198 8 RNA RNA NNP cord-007714-n3omlvfl 198 9 quality quality NN cord-007714-n3omlvfl 198 10 control control NN cord-007714-n3omlvfl 198 11 which which WDT cord-007714-n3omlvfl 198 12 involve involve VBP cord-007714-n3omlvfl 198 13 polyadenylation polyadenylation NN cord-007714-n3omlvfl 198 14 of of IN cord-007714-n3omlvfl 198 15 aberrant aberrant JJ cord-007714-n3omlvfl 198 16 RNA RNA NNP cord-007714-n3omlvfl 198 17 species specie NNS cord-007714-n3omlvfl 198 18 by by IN cord-007714-n3omlvfl 198 19 the the DT cord-007714-n3omlvfl 198 20 TRAMP tramp NN cord-007714-n3omlvfl 198 21 complex complex NN cord-007714-n3omlvfl 198 22 before before IN cord-007714-n3omlvfl 198 23 their -PRON- PRP$ cord-007714-n3omlvfl 198 24 degradation degradation NN cord-007714-n3omlvfl 198 25 may may MD cord-007714-n3omlvfl 198 26 explain explain VB cord-007714-n3omlvfl 198 27 the the DT cord-007714-n3omlvfl 198 28 accumulation accumulation NN cord-007714-n3omlvfl 198 29 of of IN cord-007714-n3omlvfl 198 30 polyadenylated polyadenylate VBN cord-007714-n3omlvfl 198 31 RNA RNA NNP cord-007714-n3omlvfl 198 32 species specie NNS cord-007714-n3omlvfl 198 33 in in IN cord-007714-n3omlvfl 198 34 some some DT cord-007714-n3omlvfl 198 35 of of IN cord-007714-n3omlvfl 198 36 the the DT cord-007714-n3omlvfl 198 37 yeast yeast NN cord-007714-n3omlvfl 198 38 mutants mutant NNS cord-007714-n3omlvfl 198 39 ( ( -LRB- cord-007714-n3omlvfl 198 40 Carneiro Carneiro NNP cord-007714-n3omlvfl 198 41 et et NNP cord-007714-n3omlvfl 198 42 al al NNP cord-007714-n3omlvfl 198 43 . . NNP cord-007714-n3omlvfl 198 44 2007 2007 CD cord-007714-n3omlvfl 198 45 ) ) -RRB- cord-007714-n3omlvfl 198 46 . . . cord-007714-n3omlvfl 199 1 In in IN cord-007714-n3omlvfl 199 2 mammalian mammalian JJ cord-007714-n3omlvfl 199 3 cells cell NNS cord-007714-n3omlvfl 199 4 , , , cord-007714-n3omlvfl 199 5 some some DT cord-007714-n3omlvfl 199 6 spliced splice VBN cord-007714-n3omlvfl 199 7 mRNAs mRNAs '' cord-007714-n3omlvfl 200 1 ( ( -LRB- cord-007714-n3omlvfl 200 2 e.g. e.g. IN cord-007714-n3omlvfl 200 3 c c NNP cord-007714-n3omlvfl 200 4 - - HYPH cord-007714-n3omlvfl 200 5 myc myc NNP cord-007714-n3omlvfl 200 6 ) ) -RRB- cord-007714-n3omlvfl 200 7 were be VBD cord-007714-n3omlvfl 200 8 localised localise VBN cord-007714-n3omlvfl 200 9 to to IN cord-007714-n3omlvfl 200 10 the the DT cord-007714-n3omlvfl 200 11 nucleolus nucleolus NN cord-007714-n3omlvfl 200 12 while while IN cord-007714-n3omlvfl 200 13 their -PRON- PRP$ cord-007714-n3omlvfl 200 14 unspliced unsplice VBN cord-007714-n3omlvfl 200 15 versions version NNS cord-007714-n3omlvfl 200 16 were be VBD cord-007714-n3omlvfl 200 17 found find VBN cord-007714-n3omlvfl 200 18 in in IN cord-007714-n3omlvfl 200 19 the the DT cord-007714-n3omlvfl 200 20 nucleoplasm nucleoplasm NN cord-007714-n3omlvfl 200 21 ( ( -LRB- cord-007714-n3omlvfl 200 22 Bond Bond NNP cord-007714-n3omlvfl 200 23 and and CC cord-007714-n3omlvfl 200 24 Wold Wold NNP cord-007714-n3omlvfl 200 25 1993 1993 CD cord-007714-n3omlvfl 200 26 ) ) -RRB- cord-007714-n3omlvfl 200 27 . . . cord-007714-n3omlvfl 201 1 Finally finally RB cord-007714-n3omlvfl 201 2 , , , cord-007714-n3omlvfl 201 3 the the DT cord-007714-n3omlvfl 201 4 nucleolar nucleolar JJ cord-007714-n3omlvfl 201 5 targeting target VBG cord-007714-n3omlvfl 201 6 of of IN cord-007714-n3omlvfl 201 7 some some DT cord-007714-n3omlvfl 201 8 animal animal NN cord-007714-n3omlvfl 201 9 viral viral JJ cord-007714-n3omlvfl 201 10 proteins protein NNS cord-007714-n3omlvfl 201 11 regulates regulate VBZ cord-007714-n3omlvfl 201 12 viral viral JJ cord-007714-n3omlvfl 201 13 mRNA mRNA NNP cord-007714-n3omlvfl 201 14 export export NN cord-007714-n3omlvfl 201 15 and and CC cord-007714-n3omlvfl 201 16 is be VBZ cord-007714-n3omlvfl 201 17 essential essential JJ cord-007714-n3omlvfl 201 18 to to IN cord-007714-n3omlvfl 201 19 the the DT cord-007714-n3omlvfl 201 20 virus virus NN cord-007714-n3omlvfl 201 21 life life NN cord-007714-n3omlvfl 201 22 cycle cycle NN cord-007714-n3omlvfl 201 23 , , , cord-007714-n3omlvfl 201 24 being be VBG cord-007714-n3omlvfl 201 25 required require VBN cord-007714-n3omlvfl 201 26 for for IN cord-007714-n3omlvfl 201 27 viral viral JJ cord-007714-n3omlvfl 201 28 replication replication NN cord-007714-n3omlvfl 201 29 or or CC cord-007714-n3omlvfl 201 30 diverting divert VBG cord-007714-n3omlvfl 201 31 normal normal JJ cord-007714-n3omlvfl 201 32 host host NN cord-007714-n3omlvfl 201 33 cell cell NN cord-007714-n3omlvfl 201 34 functions function NNS cord-007714-n3omlvfl 201 35 ( ( -LRB- cord-007714-n3omlvfl 201 36 Hiscox Hiscox NNP cord-007714-n3omlvfl 201 37 2002 2002 CD cord-007714-n3omlvfl 201 38 ( ( -LRB- cord-007714-n3omlvfl 201 39 Hiscox Hiscox NNP cord-007714-n3omlvfl 201 40 , , , cord-007714-n3omlvfl 201 41 2007 2007 CD cord-007714-n3omlvfl 201 42 . . . cord-007714-n3omlvfl 202 1 Whether whether IN cord-007714-n3omlvfl 202 2 the the DT cord-007714-n3omlvfl 202 3 nucleolus nucleolus NN cord-007714-n3omlvfl 202 4 is be VBZ cord-007714-n3omlvfl 202 5 directly directly RB cord-007714-n3omlvfl 202 6 involved involve VBN cord-007714-n3omlvfl 202 7 in in IN cord-007714-n3omlvfl 202 8 mRNA mRNA NNP cord-007714-n3omlvfl 202 9 export export NN cord-007714-n3omlvfl 202 10 is be VBZ cord-007714-n3omlvfl 202 11 still still RB cord-007714-n3omlvfl 202 12 an an DT cord-007714-n3omlvfl 202 13 open open JJ cord-007714-n3omlvfl 202 14 question question NN cord-007714-n3omlvfl 202 15 . . . cord-007714-n3omlvfl 203 1 Recent recent JJ cord-007714-n3omlvfl 203 2 proteomic proteomic NN cord-007714-n3omlvfl 203 3 and and CC cord-007714-n3omlvfl 203 4 RNomic RNomic NNP cord-007714-n3omlvfl 203 5 analyses analysis NNS cord-007714-n3omlvfl 203 6 of of IN cord-007714-n3omlvfl 203 7 nucleoli nucleoli NNP cord-007714-n3omlvfl 203 8 have have VBP cord-007714-n3omlvfl 203 9 again again RB cord-007714-n3omlvfl 203 10 raised raise VBN cord-007714-n3omlvfl 203 11 the the DT cord-007714-n3omlvfl 203 12 question question NN cord-007714-n3omlvfl 203 13 of of IN cord-007714-n3omlvfl 203 14 the the DT cord-007714-n3omlvfl 203 15 function function NN cord-007714-n3omlvfl 203 16 of of IN cord-007714-n3omlvfl 203 17 the the DT cord-007714-n3omlvfl 203 18 nucleolus nucleolus NN cord-007714-n3omlvfl 203 19 in in IN cord-007714-n3omlvfl 203 20 mRNA mRNA NNP cord-007714-n3omlvfl 203 21 biogenesis biogenesis NN cord-007714-n3omlvfl 203 22 . . . cord-007714-n3omlvfl 204 1 Proteomics Proteomics NNP cord-007714-n3omlvfl 204 2 of of IN cord-007714-n3omlvfl 204 3 human human NN cord-007714-n3omlvfl 204 4 and and CC cord-007714-n3omlvfl 204 5 plant plant NN cord-007714-n3omlvfl 204 6 nucleoli nucleoli NNP cord-007714-n3omlvfl 204 7 identified identify VBD cord-007714-n3omlvfl 204 8 almost almost RB cord-007714-n3omlvfl 204 9 700 700 CD cord-007714-n3omlvfl 204 10 and and CC cord-007714-n3omlvfl 204 11 217 217 CD cord-007714-n3omlvfl 204 12 proteins protein NNS cord-007714-n3omlvfl 204 13 , , , cord-007714-n3omlvfl 204 14 respectively respectively RB cord-007714-n3omlvfl 205 1 ( ( -LRB- cord-007714-n3omlvfl 205 2 Andersen Andersen NNP cord-007714-n3omlvfl 205 3 et et NNP cord-007714-n3omlvfl 205 4 al al NNP cord-007714-n3omlvfl 205 5 . . . cord-007714-n3omlvfl 206 1 2002 2002 CD cord-007714-n3omlvfl 207 1 Scherl Scherl NNP cord-007714-n3omlvfl 207 2 et et NNP cord-007714-n3omlvfl 207 3 al al NNP cord-007714-n3omlvfl 207 4 . . . cord-007714-n3omlvfl 208 1 2002 2002 CD cord-007714-n3omlvfl 208 2 ; ; : cord-007714-n3omlvfl 208 3 Pendle Pendle NNP cord-007714-n3omlvfl 208 4 et et NNP cord-007714-n3omlvfl 208 5 al al NNP cord-007714-n3omlvfl 208 6 . . . cord-007714-n3omlvfl 208 7 2005 2005 CD cord-007714-n3omlvfl 209 1 ; ; : cord-007714-n3omlvfl 209 2 Leung Leung NNP cord-007714-n3omlvfl 209 3 et et NNP cord-007714-n3omlvfl 209 4 al al NNP cord-007714-n3omlvfl 209 5 . . . cord-007714-n3omlvfl 209 6 2006 2006 CD cord-007714-n3omlvfl 209 7 ) ) -RRB- cord-007714-n3omlvfl 209 8 . . . cord-007714-n3omlvfl 210 1 The the DT cord-007714-n3omlvfl 210 2 plant plant NN cord-007714-n3omlvfl 210 3 proteome proteome NN cord-007714-n3omlvfl 210 4 contained contain VBD cord-007714-n3omlvfl 210 5 many many JJ cord-007714-n3omlvfl 210 6 expected expect VBN cord-007714-n3omlvfl 210 7 nucleolar nucleolar JJ cord-007714-n3omlvfl 210 8 , , , cord-007714-n3omlvfl 210 9 ribosome ribosome NN cord-007714-n3omlvfl 210 10 biogenesis biogenesis NN cord-007714-n3omlvfl 210 11 and and CC cord-007714-n3omlvfl 210 12 ribosomal ribosomal JJ cord-007714-n3omlvfl 210 13 proteins protein NNS cord-007714-n3omlvfl 210 14 as as RB cord-007714-n3omlvfl 210 15 well well RB cord-007714-n3omlvfl 210 16 as as IN cord-007714-n3omlvfl 210 17 core core NN cord-007714-n3omlvfl 210 18 snoRNP snornp NN cord-007714-n3omlvfl 210 19 proteins protein NNS cord-007714-n3omlvfl 210 20 and and CC cord-007714-n3omlvfl 210 21 proteins protein NNS cord-007714-n3omlvfl 210 22 involved involve VBN cord-007714-n3omlvfl 210 23 in in IN cord-007714-n3omlvfl 210 24 snoRNP snornp NN cord-007714-n3omlvfl 210 25 biogenesis biogenesis NN cord-007714-n3omlvfl 210 26 ( ( -LRB- cord-007714-n3omlvfl 210 27 Pendle Pendle NNP cord-007714-n3omlvfl 210 28 et et NNP cord-007714-n3omlvfl 210 29 al al NNP cord-007714-n3omlvfl 210 30 . . NNP cord-007714-n3omlvfl 210 31 2005 2005 CD cord-007714-n3omlvfl 210 32 ) ) -RRB- cord-007714-n3omlvfl 210 33 . . . cord-007714-n3omlvfl 211 1 Unexpectedly unexpectedly RB cord-007714-n3omlvfl 211 2 , , , cord-007714-n3omlvfl 211 3 many many JJ cord-007714-n3omlvfl 211 4 components component NNS cord-007714-n3omlvfl 211 5 of of IN cord-007714-n3omlvfl 211 6 mRNA mrna NN cord-007714-n3omlvfl 211 7 splicing splicing NN cord-007714-n3omlvfl 211 8 and and CC cord-007714-n3omlvfl 211 9 translation translation NN cord-007714-n3omlvfl 211 10 were be VBD cord-007714-n3omlvfl 211 11 found find VBN cord-007714-n3omlvfl 211 12 in in IN cord-007714-n3omlvfl 211 13 the the DT cord-007714-n3omlvfl 211 14 plant plant NN cord-007714-n3omlvfl 211 15 nucleolus nucleolus NN cord-007714-n3omlvfl 211 16 , , , cord-007714-n3omlvfl 211 17 an an DT cord-007714-n3omlvfl 211 18 observation observation NN cord-007714-n3omlvfl 211 19 also also RB cord-007714-n3omlvfl 211 20 made make VBN cord-007714-n3omlvfl 211 21 in in IN cord-007714-n3omlvfl 211 22 the the DT cord-007714-n3omlvfl 211 23 human human JJ cord-007714-n3omlvfl 211 24 nucleolar nucleolar JJ cord-007714-n3omlvfl 211 25 proteome proteome NN cord-007714-n3omlvfl 211 26 ( ( -LRB- cord-007714-n3omlvfl 211 27 Andersen Andersen NNP cord-007714-n3omlvfl 211 28 et et NNP cord-007714-n3omlvfl 211 29 al al NNP cord-007714-n3omlvfl 211 30 . . . cord-007714-n3omlvfl 211 31 2002 2002 CD cord-007714-n3omlvfl 211 32 ; ; : cord-007714-n3omlvfl 211 33 Scherl Scherl NNP cord-007714-n3omlvfl 211 34 et et NNP cord-007714-n3omlvfl 211 35 al al NNP cord-007714-n3omlvfl 211 36 . . . cord-007714-n3omlvfl 211 37 2002 2002 CD cord-007714-n3omlvfl 211 38 ) ) -RRB- cord-007714-n3omlvfl 211 39 . . . cord-007714-n3omlvfl 212 1 In in IN cord-007714-n3omlvfl 212 2 particular particular JJ cord-007714-n3omlvfl 212 3 , , , cord-007714-n3omlvfl 212 4 the the DT cord-007714-n3omlvfl 212 5 plant plant NN cord-007714-n3omlvfl 212 6 nucleolar nucleolar NNP cord-007714-n3omlvfl 212 7 proteome proteome NN cord-007714-n3omlvfl 212 8 contained contain VBD cord-007714-n3omlvfl 212 9 exon exon NN cord-007714-n3omlvfl 212 10 junction junction NN cord-007714-n3omlvfl 212 11 complex complex NN cord-007714-n3omlvfl 212 12 ( ( -LRB- cord-007714-n3omlvfl 212 13 EJC EJC NNP cord-007714-n3omlvfl 212 14 ) ) -RRB- cord-007714-n3omlvfl 212 15 proteins protein NNS cord-007714-n3omlvfl 212 16 which which WDT cord-007714-n3omlvfl 212 17 were be VBD cord-007714-n3omlvfl 212 18 also also RB cord-007714-n3omlvfl 212 19 shown show VBN cord-007714-n3omlvfl 212 20 to to TO cord-007714-n3omlvfl 212 21 be be VB cord-007714-n3omlvfl 212 22 associated associate VBN cord-007714-n3omlvfl 212 23 with with IN cord-007714-n3omlvfl 212 24 nucleoli nucleoli NNP cord-007714-n3omlvfl 212 25 by by IN cord-007714-n3omlvfl 212 26 localisation localisation NN cord-007714-n3omlvfl 212 27 of of IN cord-007714-n3omlvfl 212 28 GFP GFP NNP cord-007714-n3omlvfl 212 29 fusions fusion NNS cord-007714-n3omlvfl 213 1 ( ( -LRB- cord-007714-n3omlvfl 213 2 Pendle Pendle NNP cord-007714-n3omlvfl 213 3 et et NNP cord-007714-n3omlvfl 213 4 al al NNP cord-007714-n3omlvfl 213 5 . . NNP cord-007714-n3omlvfl 213 6 2005 2005 CD cord-007714-n3omlvfl 213 7 ) ) -RRB- cord-007714-n3omlvfl 213 8 . . . cord-007714-n3omlvfl 214 1 In in IN cord-007714-n3omlvfl 214 2 contrast contrast NN cord-007714-n3omlvfl 214 3 , , , cord-007714-n3omlvfl 214 4 EJC EJC NNP cord-007714-n3omlvfl 214 5 proteins protein NNS cord-007714-n3omlvfl 214 6 were be VBD cord-007714-n3omlvfl 214 7 detected detect VBN cord-007714-n3omlvfl 214 8 in in IN cord-007714-n3omlvfl 214 9 the the DT cord-007714-n3omlvfl 214 10 human human JJ cord-007714-n3omlvfl 214 11 nucleolar nucleolar JJ cord-007714-n3omlvfl 214 12 proteome proteome NN cord-007714-n3omlvfl 214 13 but but CC cord-007714-n3omlvfl 214 14 have have VBP cord-007714-n3omlvfl 214 15 not not RB cord-007714-n3omlvfl 214 16 been be VBN cord-007714-n3omlvfl 214 17 observed observe VBN cord-007714-n3omlvfl 214 18 in in IN cord-007714-n3omlvfl 214 19 the the DT cord-007714-n3omlvfl 214 20 nucleolus nucleolus NN cord-007714-n3omlvfl 214 21 ( ( -LRB- cord-007714-n3omlvfl 215 1 Custódio Custódio NNP cord-007714-n3omlvfl 215 2 et et NNP cord-007714-n3omlvfl 215 3 al al NNP cord-007714-n3omlvfl 215 4 . . . cord-007714-n3omlvfl 216 1 2004 2004 CD cord-007714-n3omlvfl 216 2 ; ; : cord-007714-n3omlvfl 216 3 Palacios Palacios NNP cord-007714-n3omlvfl 216 4 et et NNP cord-007714-n3omlvfl 216 5 al al NNP cord-007714-n3omlvfl 216 6 . . . cord-007714-n3omlvfl 216 7 2004 2004 CD cord-007714-n3omlvfl 216 8 ) ) -RRB- cord-007714-n3omlvfl 216 9 , , . cord-007714-n3omlvfl 217 1 suggesting suggest VBG cord-007714-n3omlvfl 217 2 potential potential JJ cord-007714-n3omlvfl 217 3 differences difference NNS cord-007714-n3omlvfl 217 4 in in IN cord-007714-n3omlvfl 217 5 EJC EJC NNP cord-007714-n3omlvfl 217 6 assembly assembly NN cord-007714-n3omlvfl 217 7 , , , cord-007714-n3omlvfl 217 8 storage storage NN cord-007714-n3omlvfl 217 9 or or CC cord-007714-n3omlvfl 217 10 function function NN cord-007714-n3omlvfl 217 11 between between IN cord-007714-n3omlvfl 217 12 animals animal NNS cord-007714-n3omlvfl 217 13 and and CC cord-007714-n3omlvfl 217 14 plants plant NNS cord-007714-n3omlvfl 217 15 . . . cord-007714-n3omlvfl 218 1 The the DT cord-007714-n3omlvfl 218 2 EJC EJC NNP cord-007714-n3omlvfl 218 3 is be VBZ cord-007714-n3omlvfl 218 4 a a DT cord-007714-n3omlvfl 218 5 multi multi JJ cord-007714-n3omlvfl 218 6 - - JJ cord-007714-n3omlvfl 218 7 protein protein JJ cord-007714-n3omlvfl 218 8 complex complex NN cord-007714-n3omlvfl 218 9 that that WDT cord-007714-n3omlvfl 218 10 is be VBZ cord-007714-n3omlvfl 218 11 deposited deposit VBN cord-007714-n3omlvfl 218 12 upstream upstream RB cord-007714-n3omlvfl 218 13 of of IN cord-007714-n3omlvfl 218 14 splice splice NN cord-007714-n3omlvfl 218 15 junctions junction NNS cord-007714-n3omlvfl 218 16 in in IN cord-007714-n3omlvfl 218 17 mRNAs mRNAs NNPS cord-007714-n3omlvfl 218 18 after after IN cord-007714-n3omlvfl 218 19 intron intron NN cord-007714-n3omlvfl 218 20 splicing splicing NN cord-007714-n3omlvfl 218 21 . . . cord-007714-n3omlvfl 219 1 It -PRON- PRP cord-007714-n3omlvfl 219 2 contains contain VBZ cord-007714-n3omlvfl 219 3 proteins protein NNS cord-007714-n3omlvfl 219 4 that that WDT cord-007714-n3omlvfl 219 5 are be VBP cord-007714-n3omlvfl 219 6 recruited recruit VBN cord-007714-n3omlvfl 219 7 as as IN cord-007714-n3omlvfl 219 8 part part NN cord-007714-n3omlvfl 219 9 of of IN cord-007714-n3omlvfl 219 10 the the DT cord-007714-n3omlvfl 219 11 spliceosome spliceosome NNP cord-007714-n3omlvfl 219 12 , , , cord-007714-n3omlvfl 219 13 that that WDT cord-007714-n3omlvfl 219 14 interact interact VBP cord-007714-n3omlvfl 219 15 with with IN cord-007714-n3omlvfl 219 16 mRNP mRNP VBG cord-007714-n3omlvfl 219 17 export export NN cord-007714-n3omlvfl 219 18 adaptors adaptor NNS cord-007714-n3omlvfl 219 19 , , , cord-007714-n3omlvfl 219 20 that that WDT cord-007714-n3omlvfl 219 21 enhance enhance VBP cord-007714-n3omlvfl 219 22 translation translation NN cord-007714-n3omlvfl 219 23 or or CC cord-007714-n3omlvfl 219 24 that that WDT cord-007714-n3omlvfl 219 25 are be VBP cord-007714-n3omlvfl 219 26 involved involve VBN cord-007714-n3omlvfl 219 27 in in IN cord-007714-n3omlvfl 219 28 nonsensemediated nonsensemediated JJ cord-007714-n3omlvfl 219 29 decay decay NN cord-007714-n3omlvfl 219 30 ( ( -LRB- cord-007714-n3omlvfl 220 1 Stutz Stutz NNP cord-007714-n3omlvfl 220 2 and and CC cord-007714-n3omlvfl 220 3 Izzuralde Izzuralde NNP cord-007714-n3omlvfl 220 4 2003 2003 CD cord-007714-n3omlvfl 220 5 ; ; : cord-007714-n3omlvfl 220 6 Maquat Maquat NNP cord-007714-n3omlvfl 220 7 2004 2004 CD cord-007714-n3omlvfl 220 8 ; ; : cord-007714-n3omlvfl 220 9 Lejeune Lejeune NNP cord-007714-n3omlvfl 220 10 and and CC cord-007714-n3omlvfl 220 11 Maquat Maquat NNP cord-007714-n3omlvfl 220 12 2005 2005 CD cord-007714-n3omlvfl 220 13 ; ; : cord-007714-n3omlvfl 220 14 Tange Tange NNP cord-007714-n3omlvfl 220 15 et et NNP cord-007714-n3omlvfl 220 16 al al NNP cord-007714-n3omlvfl 220 17 . . . cord-007714-n3omlvfl 221 1 2004 2004 CD cord-007714-n3omlvfl 221 2 ; ; : cord-007714-n3omlvfl 221 3 Andersen Andersen NNP cord-007714-n3omlvfl 221 4 et et NNP cord-007714-n3omlvfl 221 5 al al NNP cord-007714-n3omlvfl 221 6 . . . cord-007714-n3omlvfl 221 7 2006 2006 CD cord-007714-n3omlvfl 221 8 ) ) -RRB- cord-007714-n3omlvfl 221 9 . . . cord-007714-n3omlvfl 222 1 As as IN cord-007714-n3omlvfl 222 2 such such JJ cord-007714-n3omlvfl 222 3 , , , cord-007714-n3omlvfl 222 4 EJC EJC NNP cord-007714-n3omlvfl 222 5 proteins protein NNS cord-007714-n3omlvfl 222 6 link link VBP cord-007714-n3omlvfl 222 7 gene gene NN cord-007714-n3omlvfl 222 8 transcription transcription NN cord-007714-n3omlvfl 222 9 with with IN cord-007714-n3omlvfl 222 10 splicing splicing NN cord-007714-n3omlvfl 222 11 , , , cord-007714-n3omlvfl 222 12 export export NN cord-007714-n3omlvfl 222 13 , , , cord-007714-n3omlvfl 222 14 translation translation NN cord-007714-n3omlvfl 222 15 and and CC cord-007714-n3omlvfl 222 16 nonsense nonsense NN cord-007714-n3omlvfl 222 17 - - HYPH cord-007714-n3omlvfl 222 18 mediated mediate VBN cord-007714-n3omlvfl 222 19 decay decay NN cord-007714-n3omlvfl 222 20 ( ( -LRB- cord-007714-n3omlvfl 222 21 Fig fig NN cord-007714-n3omlvfl 222 22 . . . cord-007714-n3omlvfl 222 23 3 3 CD cord-007714-n3omlvfl 222 24 ) ) -RRB- cord-007714-n3omlvfl 222 25 . . . cord-007714-n3omlvfl 223 1 The the DT cord-007714-n3omlvfl 223 2 discovery discovery NN cord-007714-n3omlvfl 223 3 of of IN cord-007714-n3omlvfl 223 4 EJC EJC NNP cord-007714-n3omlvfl 223 5 proteins protein NNS cord-007714-n3omlvfl 223 6 , , , cord-007714-n3omlvfl 223 7 as as RB cord-007714-n3omlvfl 223 8 well well RB cord-007714-n3omlvfl 223 9 as as IN cord-007714-n3omlvfl 223 10 splicing splicing NN cord-007714-n3omlvfl 223 11 and and CC cord-007714-n3omlvfl 223 12 translation translation NN cord-007714-n3omlvfl 223 13 factors factor NNS cord-007714-n3omlvfl 223 14 , , , cord-007714-n3omlvfl 223 15 associated associate VBN cord-007714-n3omlvfl 223 16 with with IN cord-007714-n3omlvfl 223 17 the the DT cord-007714-n3omlvfl 223 18 plant plant NN cord-007714-n3omlvfl 223 19 nucleolus nucleolus NN cord-007714-n3omlvfl 223 20 suggested suggest VBD cord-007714-n3omlvfl 223 21 that that IN cord-007714-n3omlvfl 223 22 aspects aspect NNS cord-007714-n3omlvfl 223 23 of of IN cord-007714-n3omlvfl 223 24 mRNA mrna NN cord-007714-n3omlvfl 223 25 biogenesis biogenesis NN cord-007714-n3omlvfl 223 26 in in IN cord-007714-n3omlvfl 223 27 plants plant NNS cord-007714-n3omlvfl 223 28 involve involve VBP cord-007714-n3omlvfl 223 29 the the DT cord-007714-n3omlvfl 223 30 nucleolus nucleolus NN cord-007714-n3omlvfl 223 31 . . . cord-007714-n3omlvfl 224 1 Whether whether IN cord-007714-n3omlvfl 224 2 mRNAs mrna NNS cord-007714-n3omlvfl 224 3 are be VBP cord-007714-n3omlvfl 224 4 present present JJ cord-007714-n3omlvfl 224 5 in in IN cord-007714-n3omlvfl 224 6 the the DT cord-007714-n3omlvfl 224 7 plant plant NN cord-007714-n3omlvfl 224 8 nucleolus nucleolus NN cord-007714-n3omlvfl 224 9 was be VBD cord-007714-n3omlvfl 224 10 addressed address VBN cord-007714-n3omlvfl 224 11 by by IN cord-007714-n3omlvfl 224 12 sequencing sequence VBG cord-007714-n3omlvfl 224 13 clones clone NNS cord-007714-n3omlvfl 224 14 from from IN cord-007714-n3omlvfl 224 15 cDNA cdna NN cord-007714-n3omlvfl 224 16 libraries library NNS cord-007714-n3omlvfl 224 17 made make VBN cord-007714-n3omlvfl 224 18 from from IN cord-007714-n3omlvfl 224 19 cell cell NN cord-007714-n3omlvfl 224 20 cultures culture NNS cord-007714-n3omlvfl 224 21 , , , cord-007714-n3omlvfl 224 22 isolated isolate VBN cord-007714-n3omlvfl 224 23 nuclei nucleus NNS cord-007714-n3omlvfl 224 24 and and CC cord-007714-n3omlvfl 224 25 purified purify VBN cord-007714-n3omlvfl 224 26 nucleoli nucleoli NNP cord-007714-n3omlvfl 224 27 . . . cord-007714-n3omlvfl 225 1 Not not RB cord-007714-n3omlvfl 225 2 only only RB cord-007714-n3omlvfl 225 3 were be VBD cord-007714-n3omlvfl 225 4 mRNAs mrna VBN cord-007714-n3omlvfl 225 5 detected detect VBN cord-007714-n3omlvfl 225 6 in in IN cord-007714-n3omlvfl 225 7 the the DT cord-007714-n3omlvfl 225 8 nucleolar nucleolar NNP cord-007714-n3omlvfl 225 9 cDNA cDNA NNP cord-007714-n3omlvfl 225 10 library library NNP cord-007714-n3omlvfl 225 11 but but CC cord-007714-n3omlvfl 225 12 the the DT cord-007714-n3omlvfl 225 13 abundance abundance NN cord-007714-n3omlvfl 225 14 of of IN cord-007714-n3omlvfl 225 15 different different JJ cord-007714-n3omlvfl 225 16 classes class NNS cord-007714-n3omlvfl 225 17 of of IN cord-007714-n3omlvfl 225 18 mRNAs mRNAs NNPS cord-007714-n3omlvfl 225 19 was be VBD cord-007714-n3omlvfl 225 20 significantly significantly RB cord-007714-n3omlvfl 225 21 different different JJ cord-007714-n3omlvfl 225 22 between between IN cord-007714-n3omlvfl 225 23 the the DT cord-007714-n3omlvfl 225 24 three three CD cord-007714-n3omlvfl 225 25 libraries library NNS cord-007714-n3omlvfl 225 26 ( ( -LRB- cord-007714-n3omlvfl 225 27 Fig Fig NNP cord-007714-n3omlvfl 225 28 . . NNP cord-007714-n3omlvfl 225 29 4 4 CD cord-007714-n3omlvfl 225 30 ; ; : cord-007714-n3omlvfl 225 31 Kim Kim NNP cord-007714-n3omlvfl 225 32 et et NNP cord-007714-n3omlvfl 225 33 al al NNP cord-007714-n3omlvfl 225 34 . . NNP cord-007714-n3omlvfl 225 35 , , , cord-007714-n3omlvfl 225 36 unpublished unpublished JJ cord-007714-n3omlvfl 225 37 ) ) -RRB- cord-007714-n3omlvfl 225 38 . . . cord-007714-n3omlvfl 226 1 The the DT cord-007714-n3omlvfl 226 2 mRNAs mRNAs NNPS cord-007714-n3omlvfl 226 3 fell fall VBD cord-007714-n3omlvfl 226 4 into into IN cord-007714-n3omlvfl 226 5 three three CD cord-007714-n3omlvfl 226 6 classes class NNS cord-007714-n3omlvfl 226 7 : : : cord-007714-n3omlvfl 226 8 fully fully RB cord-007714-n3omlvfl 226 9 spliced splice VBN cord-007714-n3omlvfl 226 10 transcripts transcript NNS cord-007714-n3omlvfl 226 11 , , , cord-007714-n3omlvfl 226 12 transcripts transcript NNS cord-007714-n3omlvfl 226 13 from from IN cord-007714-n3omlvfl 226 14 single single JJ cord-007714-n3omlvfl 226 15 exon exon NN cord-007714-n3omlvfl 226 16 genes gene NNS cord-007714-n3omlvfl 226 17 ( ( -LRB- cord-007714-n3omlvfl 226 18 i.e. i.e. FW cord-007714-n3omlvfl 226 19 that that WDT cord-007714-n3omlvfl 226 20 had have VBD cord-007714-n3omlvfl 226 21 not not RB cord-007714-n3omlvfl 226 22 undergone undergo VBN cord-007714-n3omlvfl 226 23 splicing splicing NN cord-007714-n3omlvfl 226 24 ) ) -RRB- cord-007714-n3omlvfl 226 25 and and CC cord-007714-n3omlvfl 226 26 aberrantly aberrantly RB cord-007714-n3omlvfl 226 27 spliced splice VBN cord-007714-n3omlvfl 226 28 transcripts transcript NNS cord-007714-n3omlvfl 226 29 . . . cord-007714-n3omlvfl 227 1 Aberrantly aberrantly RB cord-007714-n3omlvfl 227 2 spliced splice VBN cord-007714-n3omlvfl 227 3 transcripts transcript NNS cord-007714-n3omlvfl 227 4 include include VBP cord-007714-n3omlvfl 227 5 transcripts transcript NNS cord-007714-n3omlvfl 227 6 with with IN cord-007714-n3omlvfl 227 7 potential potential JJ cord-007714-n3omlvfl 227 8 splicing splicing NN cord-007714-n3omlvfl 227 9 errors error NNS cord-007714-n3omlvfl 227 10 , , , cord-007714-n3omlvfl 227 11 incompletely incompletely RB cord-007714-n3omlvfl 227 12 spliced splice VBN cord-007714-n3omlvfl 227 13 transcripts transcript NNS cord-007714-n3omlvfl 227 14 ( ( -LRB- cord-007714-n3omlvfl 227 15 where where WRB cord-007714-n3omlvfl 227 16 one one CD cord-007714-n3omlvfl 227 17 or or CC cord-007714-n3omlvfl 227 18 more more JJR cord-007714-n3omlvfl 227 19 introns intron NNS cord-007714-n3omlvfl 227 20 is be VBZ cord-007714-n3omlvfl 227 21 unspliced unsplice VBN cord-007714-n3omlvfl 227 22 ) ) -RRB- cord-007714-n3omlvfl 227 23 and and CC cord-007714-n3omlvfl 227 24 alternatively alternatively RB cord-007714-n3omlvfl 227 25 spliced splice VBN cord-007714-n3omlvfl 227 26 transcripts transcript NNS cord-007714-n3omlvfl 227 27 . . . cord-007714-n3omlvfl 228 1 Although although IN cord-007714-n3omlvfl 228 2 it -PRON- PRP cord-007714-n3omlvfl 228 3 is be VBZ cord-007714-n3omlvfl 228 4 difficult difficult JJ cord-007714-n3omlvfl 228 5 to to TO cord-007714-n3omlvfl 228 6 distinguish distinguish VB cord-007714-n3omlvfl 228 7 among among IN cord-007714-n3omlvfl 228 8 these these DT cord-007714-n3omlvfl 228 9 possibilities possibility NNS cord-007714-n3omlvfl 228 10 , , , cord-007714-n3omlvfl 228 11 the the DT cord-007714-n3omlvfl 228 12 aberrant aberrant JJ cord-007714-n3omlvfl 228 13 nature nature NN cord-007714-n3omlvfl 228 14 of of IN cord-007714-n3omlvfl 228 15 this this DT cord-007714-n3omlvfl 228 16 class class NN cord-007714-n3omlvfl 228 17 of of IN cord-007714-n3omlvfl 228 18 the the DT cord-007714-n3omlvfl 228 19 transcripts transcript NNS cord-007714-n3omlvfl 228 20 in in IN cord-007714-n3omlvfl 228 21 the the DT cord-007714-n3omlvfl 228 22 nucleolus nucleolus NN cord-007714-n3omlvfl 228 23 was be VBD cord-007714-n3omlvfl 228 24 demonstrated demonstrate VBN cord-007714-n3omlvfl 228 25 by by IN cord-007714-n3omlvfl 228 26 the the DT cord-007714-n3omlvfl 228 27 fact fact NN cord-007714-n3omlvfl 228 28 that that IN cord-007714-n3omlvfl 228 29 over over IN cord-007714-n3omlvfl 228 30 90 90 CD cord-007714-n3omlvfl 228 31 % % NN cord-007714-n3omlvfl 228 32 contained contain VBD cord-007714-n3omlvfl 228 33 premature premature JJ cord-007714-n3omlvfl 228 34 stop stop NN cord-007714-n3omlvfl 228 35 codons codon NNS cord-007714-n3omlvfl 228 36 . . . cord-007714-n3omlvfl 229 1 The the DT cord-007714-n3omlvfl 229 2 proportion proportion NN cord-007714-n3omlvfl 229 3 of of IN cord-007714-n3omlvfl 229 4 fully fully RB cord-007714-n3omlvfl 229 5 spliced splice VBN cord-007714-n3omlvfl 229 6 transcripts transcript NNS cord-007714-n3omlvfl 229 7 decreased decrease VBD cord-007714-n3omlvfl 229 8 from from IN cord-007714-n3omlvfl 229 9 82 82 CD cord-007714-n3omlvfl 229 10 % % NN cord-007714-n3omlvfl 229 11 in in IN cord-007714-n3omlvfl 229 12 the the DT cord-007714-n3omlvfl 229 13 whole whole JJ cord-007714-n3omlvfl 229 14 cell cell NN cord-007714-n3omlvfl 229 15 library library NN cord-007714-n3omlvfl 229 16 to to IN cord-007714-n3omlvfl 229 17 68 68 CD cord-007714-n3omlvfl 229 18 % % NN cord-007714-n3omlvfl 229 19 and and CC cord-007714-n3omlvfl 229 20 42 42 CD cord-007714-n3omlvfl 229 21 % % NN cord-007714-n3omlvfl 229 22 in in IN cord-007714-n3omlvfl 229 23 the the DT cord-007714-n3omlvfl 229 24 nuclear nuclear JJ cord-007714-n3omlvfl 229 25 and and CC cord-007714-n3omlvfl 229 26 nucleolar nucleolar JJ cord-007714-n3omlvfl 229 27 libraries library NNS cord-007714-n3omlvfl 229 28 , , , cord-007714-n3omlvfl 229 29 respectively respectively RB cord-007714-n3omlvfl 229 30 . . . cord-007714-n3omlvfl 230 1 In in IN cord-007714-n3omlvfl 230 2 contrast contrast NN cord-007714-n3omlvfl 230 3 , , , cord-007714-n3omlvfl 230 4 the the DT cord-007714-n3omlvfl 230 5 proportion proportion NN cord-007714-n3omlvfl 230 6 of of IN cord-007714-n3omlvfl 230 7 aberrantly aberrantly RB cord-007714-n3omlvfl 230 8 spliced splice VBN cord-007714-n3omlvfl 230 9 transcripts transcript NNS cord-007714-n3omlvfl 230 10 increased increase VBD cord-007714-n3omlvfl 230 11 from from IN cord-007714-n3omlvfl 230 12 2 2 CD cord-007714-n3omlvfl 230 13 % % NN cord-007714-n3omlvfl 230 14 in in IN cord-007714-n3omlvfl 230 15 the the DT cord-007714-n3omlvfl 230 16 whole whole JJ cord-007714-n3omlvfl 230 17 cell cell NN cord-007714-n3omlvfl 230 18 library library NN cord-007714-n3omlvfl 230 19 to to IN cord-007714-n3omlvfl 230 20 13 13 CD cord-007714-n3omlvfl 230 21 % % NN cord-007714-n3omlvfl 230 22 and and CC cord-007714-n3omlvfl 230 23 38 38 CD cord-007714-n3omlvfl 230 24 % % NN cord-007714-n3omlvfl 230 25 in in IN cord-007714-n3omlvfl 230 26 the the DT cord-007714-n3omlvfl 230 27 nuclear nuclear JJ cord-007714-n3omlvfl 230 28 and and CC cord-007714-n3omlvfl 230 29 nucleolar nucleolar JJ cord-007714-n3omlvfl 230 30 libraries library NNS cord-007714-n3omlvfl 230 31 , , , cord-007714-n3omlvfl 230 32 respectively respectively RB cord-007714-n3omlvfl 230 33 , , , cord-007714-n3omlvfl 230 34 while while IN cord-007714-n3omlvfl 230 35 those those DT cord-007714-n3omlvfl 230 36 of of IN cord-007714-n3omlvfl 230 37 single single JJ cord-007714-n3omlvfl 230 38 exon exon NN cord-007714-n3omlvfl 230 39 genes gene NNS cord-007714-n3omlvfl 230 40 remained remain VBD cord-007714-n3omlvfl 230 41 around around IN cord-007714-n3omlvfl 230 42 the the DT cord-007714-n3omlvfl 230 43 same same JJ cord-007714-n3omlvfl 230 44 levels level NNS cord-007714-n3omlvfl 230 45 ( ( -LRB- cord-007714-n3omlvfl 230 46 16%-20 16%-20 CD cord-007714-n3omlvfl 230 47 % % NN cord-007714-n3omlvfl 230 48 ) ) -RRB- cord-007714-n3omlvfl 231 1 ( ( -LRB- cord-007714-n3omlvfl 231 2 Fig Fig NNP cord-007714-n3omlvfl 231 3 . . . cord-007714-n3omlvfl 232 1 4 4 LS cord-007714-n3omlvfl 232 2 ; ; : cord-007714-n3omlvfl 232 3 Kim Kim NNP cord-007714-n3omlvfl 232 4 et et NNP cord-007714-n3omlvfl 232 5 al al NNP cord-007714-n3omlvfl 232 6 . . . cord-007714-n3omlvfl 233 1 , , , cord-007714-n3omlvfl 233 2 unpublished unpublished JJ cord-007714-n3omlvfl 233 3 ) ) -RRB- cord-007714-n3omlvfl 233 4 . . . cord-007714-n3omlvfl 234 1 Thus thus RB cord-007714-n3omlvfl 234 2 the the DT cord-007714-n3omlvfl 234 3 nucleolus nucleolus NN cord-007714-n3omlvfl 234 4 contained contain VBD cord-007714-n3omlvfl 234 5 enhanced enhanced JJ cord-007714-n3omlvfl 234 6 levels level NNS cord-007714-n3omlvfl 234 7 of of IN cord-007714-n3omlvfl 234 8 aberrant aberrant JJ cord-007714-n3omlvfl 234 9 mRNAs mrna NNS cord-007714-n3omlvfl 234 10 . . . cord-007714-n3omlvfl 235 1 The the DT cord-007714-n3omlvfl 235 2 unexpected unexpected JJ cord-007714-n3omlvfl 235 3 discovery discovery NN cord-007714-n3omlvfl 235 4 of of IN cord-007714-n3omlvfl 235 5 mRNAs mRNAs NNPS cord-007714-n3omlvfl 235 6 in in IN cord-007714-n3omlvfl 235 7 the the DT cord-007714-n3omlvfl 235 8 nucleolus nucleolus NN cord-007714-n3omlvfl 235 9 suggests suggest VBZ cord-007714-n3omlvfl 235 10 that that IN cord-007714-n3omlvfl 235 11 mRNAs mrnas PRP cord-007714-n3omlvfl 235 12 can can MD cord-007714-n3omlvfl 235 13 move move VB cord-007714-n3omlvfl 235 14 freely freely RB cord-007714-n3omlvfl 235 15 between between IN cord-007714-n3omlvfl 235 16 the the DT cord-007714-n3omlvfl 235 17 nucleoplasm nucleoplasm NN cord-007714-n3omlvfl 235 18 and and CC cord-007714-n3omlvfl 235 19 nucleolus nucleolus NN cord-007714-n3omlvfl 235 20 and and CC cord-007714-n3omlvfl 235 21 may may MD cord-007714-n3omlvfl 235 22 point point VB cord-007714-n3omlvfl 235 23 to to IN cord-007714-n3omlvfl 235 24 a a DT cord-007714-n3omlvfl 235 25 nucleolar nucleolar JJ cord-007714-n3omlvfl 235 26 mRNA mRNA NNP cord-007714-n3omlvfl 235 27 export export NN cord-007714-n3omlvfl 235 28 function function NN cord-007714-n3omlvfl 235 29 . . . cord-007714-n3omlvfl 236 1 The the DT cord-007714-n3omlvfl 236 2 majority majority NN cord-007714-n3omlvfl 236 3 of of IN cord-007714-n3omlvfl 236 4 aberrant aberrant JJ cord-007714-n3omlvfl 236 5 mRNAs mRNAs NNPS cord-007714-n3omlvfl 236 6 contained contain VBD cord-007714-n3omlvfl 236 7 premature premature JJ cord-007714-n3omlvfl 236 8 termination termination NN cord-007714-n3omlvfl 236 9 codons codon NNS cord-007714-n3omlvfl 236 10 , , , cord-007714-n3omlvfl 236 11 further further RB cord-007714-n3omlvfl 236 12 suggesting suggest VBG cord-007714-n3omlvfl 236 13 a a DT cord-007714-n3omlvfl 236 14 role role NN cord-007714-n3omlvfl 236 15 in in IN cord-007714-n3omlvfl 236 16 mRNA mRNA NNP cord-007714-n3omlvfl 236 17 surveillance surveillance NN cord-007714-n3omlvfl 236 18 and and CC cord-007714-n3omlvfl 236 19 nonsense nonsense NN cord-007714-n3omlvfl 236 20 - - HYPH cord-007714-n3omlvfl 236 21 mediated mediate VBN cord-007714-n3omlvfl 236 22 decay decay NN cord-007714-n3omlvfl 236 23 . . . cord-007714-n3omlvfl 237 1 This this DT cord-007714-n3omlvfl 237 2 is be VBZ cord-007714-n3omlvfl 237 3 supported support VBN cord-007714-n3omlvfl 237 4 by by IN cord-007714-n3omlvfl 237 5 the the DT cord-007714-n3omlvfl 237 6 localisation localisation NN cord-007714-n3omlvfl 237 7 of of IN cord-007714-n3omlvfl 237 8 the the DT cord-007714-n3omlvfl 237 9 NMD NMD NNP cord-007714-n3omlvfl 237 10 proteins protein NNS cord-007714-n3omlvfl 237 11 UPF2 UPF2 NNP cord-007714-n3omlvfl 237 12 and and CC cord-007714-n3omlvfl 237 13 UPF3 UPF3 NNP cord-007714-n3omlvfl 237 14 in in IN cord-007714-n3omlvfl 237 15 the the DT cord-007714-n3omlvfl 237 16 nucleolus nucleolus NN cord-007714-n3omlvfl 237 17 ( ( -LRB- cord-007714-n3omlvfl 237 18 Kim Kim NNP cord-007714-n3omlvfl 237 19 et et NNP cord-007714-n3omlvfl 237 20 al al NNP cord-007714-n3omlvfl 237 21 . . NNP cord-007714-n3omlvfl 237 22 , , , cord-007714-n3omlvfl 237 23 unpublished unpublished JJ cord-007714-n3omlvfl 237 24 ) ) -RRB- cord-007714-n3omlvfl 237 25 . . . cord-007714-n3omlvfl 238 1 Thus thus RB cord-007714-n3omlvfl 238 2 the the DT cord-007714-n3omlvfl 238 3 plant plant NN cord-007714-n3omlvfl 238 4 nucleolus nucleolus NN cord-007714-n3omlvfl 238 5 may may MD cord-007714-n3omlvfl 238 6 function function VB cord-007714-n3omlvfl 238 7 in in IN cord-007714-n3omlvfl 238 8 mRNA mRNA NNP cord-007714-n3omlvfl 238 9 export export NN cord-007714-n3omlvfl 238 10 , , , cord-007714-n3omlvfl 238 11 surveillance surveillance NN cord-007714-n3omlvfl 238 12 and and CC cord-007714-n3omlvfl 238 13 NMD NMD NNP cord-007714-n3omlvfl 238 14 . . . cord-007714-n3omlvfl 239 1 ( ( -LRB- cord-007714-n3omlvfl 239 2 2 2 LS cord-007714-n3omlvfl 239 3 ) ) -RRB- cord-007714-n3omlvfl 239 4 and and CC cord-007714-n3omlvfl 239 5 the the DT cord-007714-n3omlvfl 239 6 export export NN cord-007714-n3omlvfl 239 7 factor factor NN cord-007714-n3omlvfl 239 8 Aly Aly NNP cord-007714-n3omlvfl 239 9 / / SYM cord-007714-n3omlvfl 239 10 REF REF NNP cord-007714-n3omlvfl 239 11 . . . cord-007714-n3omlvfl 240 1 The the DT cord-007714-n3omlvfl 240 2 latter latter NN cord-007714-n3omlvfl 240 3 interacts interact VBZ cord-007714-n3omlvfl 240 4 with with IN cord-007714-n3omlvfl 240 5 the the DT cord-007714-n3omlvfl 240 6 export export NN cord-007714-n3omlvfl 240 7 adaptor adaptor NN cord-007714-n3omlvfl 240 8 dimmer dimmer NNP cord-007714-n3omlvfl 240 9 TAP TAP NNP cord-007714-n3omlvfl 240 10 / / SYM cord-007714-n3omlvfl 240 11 p15 p15 NN cord-007714-n3omlvfl 240 12 which which WDT cord-007714-n3omlvfl 240 13 , , , cord-007714-n3omlvfl 240 14 in in IN cord-007714-n3omlvfl 240 15 turn turn NN cord-007714-n3omlvfl 240 16 , , , cord-007714-n3omlvfl 240 17 interacts interact VBZ cord-007714-n3omlvfl 240 18 with with IN cord-007714-n3omlvfl 240 19 the the DT cord-007714-n3omlvfl 240 20 nuclear nuclear JJ cord-007714-n3omlvfl 240 21 pore pore NN cord-007714-n3omlvfl 240 22 complex complex NN cord-007714-n3omlvfl 240 23 , , , cord-007714-n3omlvfl 240 24 allowing allow VBG cord-007714-n3omlvfl 240 25 the the DT cord-007714-n3omlvfl 240 26 mRNP mrnp NN cord-007714-n3omlvfl 240 27 to to TO cord-007714-n3omlvfl 240 28 be be VB cord-007714-n3omlvfl 240 29 exported export VBN cord-007714-n3omlvfl 240 30 . . . cord-007714-n3omlvfl 241 1 Once once RB cord-007714-n3omlvfl 241 2 exported export VBN cord-007714-n3omlvfl 241 3 , , , cord-007714-n3omlvfl 241 4 mRNAs mRNAs NNPS cord-007714-n3omlvfl 241 5 are be VBP cord-007714-n3omlvfl 241 6 translated translate VBN cord-007714-n3omlvfl 241 7 into into IN cord-007714-n3omlvfl 241 8 proteins protein NNS cord-007714-n3omlvfl 241 9 by by IN cord-007714-n3omlvfl 241 10 ribosomes ribosome NNS cord-007714-n3omlvfl 241 11 . . . cord-007714-n3omlvfl 242 1 If if IN cord-007714-n3omlvfl 242 2 the the DT cord-007714-n3omlvfl 242 3 mRNA mrna NN cord-007714-n3omlvfl 242 4 contains contain VBZ cord-007714-n3omlvfl 242 5 a a DT cord-007714-n3omlvfl 242 6 premature premature JJ cord-007714-n3omlvfl 242 7 termination termination NN cord-007714-n3omlvfl 242 8 codon codon NN cord-007714-n3omlvfl 242 9 ( ( -LRB- cord-007714-n3omlvfl 242 10 PTC PTC NNP cord-007714-n3omlvfl 242 11 ) ) -RRB- cord-007714-n3omlvfl 242 12 , , , cord-007714-n3omlvfl 242 13 pausing pause VBG cord-007714-n3omlvfl 242 14 of of IN cord-007714-n3omlvfl 242 15 the the DT cord-007714-n3omlvfl 242 16 ribosome ribosome NN cord-007714-n3omlvfl 242 17 recruits recruit VBZ cord-007714-n3omlvfl 242 18 a a DT cord-007714-n3omlvfl 242 19 complex complex JJ cord-007714-n3omlvfl 242 20 containing contain VBG cord-007714-n3omlvfl 242 21 release release NN cord-007714-n3omlvfl 242 22 factors factor NNS cord-007714-n3omlvfl 242 23 ( ( -LRB- cord-007714-n3omlvfl 242 24 RF RF NNP cord-007714-n3omlvfl 242 25 ) ) -RRB- cord-007714-n3omlvfl 242 26 and and CC cord-007714-n3omlvfl 242 27 UPF1 UPF1 NNP cord-007714-n3omlvfl 242 28 ( ( -LRB- cord-007714-n3omlvfl 242 29 1 1 CD cord-007714-n3omlvfl 242 30 ) ) -RRB- cord-007714-n3omlvfl 242 31 . . . cord-007714-n3omlvfl 243 1 Phosphorylation Phosphorylation NNP cord-007714-n3omlvfl 243 2 of of IN cord-007714-n3omlvfl 243 3 UPF1 UPF1 NNP cord-007714-n3omlvfl 243 4 is be VBZ cord-007714-n3omlvfl 243 5 a a DT cord-007714-n3omlvfl 243 6 key key JJ cord-007714-n3omlvfl 243 7 step step NN cord-007714-n3omlvfl 243 8 in in IN cord-007714-n3omlvfl 243 9 targeting target VBG cord-007714-n3omlvfl 243 10 the the DT cord-007714-n3omlvfl 243 11 aberrant aberrant JJ cord-007714-n3omlvfl 243 12 transcript transcript NN cord-007714-n3omlvfl 243 13 for for IN cord-007714-n3omlvfl 243 14 degradation degradation NN cord-007714-n3omlvfl 243 15 . . . cord-007714-n3omlvfl 243 16 _SP cord-007714-n3omlvfl 244 1 In in IN cord-007714-n3omlvfl 244 2 eukaryotes eukaryote NNS cord-007714-n3omlvfl 244 3 , , , cord-007714-n3omlvfl 244 4 export export NN cord-007714-n3omlvfl 244 5 of of IN cord-007714-n3omlvfl 244 6 mRNPs mrnps DT cord-007714-n3omlvfl 244 7 from from IN cord-007714-n3omlvfl 244 8 the the DT cord-007714-n3omlvfl 244 9 nucleus nucleus NN cord-007714-n3omlvfl 244 10 to to IN cord-007714-n3omlvfl 244 11 the the DT cord-007714-n3omlvfl 244 12 cytoplasm cytoplasm NN cord-007714-n3omlvfl 244 13 is be VBZ cord-007714-n3omlvfl 244 14 mediated mediate VBN cord-007714-n3omlvfl 244 15 by by IN cord-007714-n3omlvfl 244 16 Aly Aly NNP cord-007714-n3omlvfl 244 17 / / SYM cord-007714-n3omlvfl 244 18 REF REF NNP cord-007714-n3omlvfl 244 19 and and CC cord-007714-n3omlvfl 244 20 UAP56 UAP56 NNP cord-007714-n3omlvfl 244 21 ( ( -LRB- cord-007714-n3omlvfl 244 22 Yra1p yra1p NN cord-007714-n3omlvfl 244 23 and and CC cord-007714-n3omlvfl 244 24 Sub2p sub2p NN cord-007714-n3omlvfl 244 25 , , , cord-007714-n3omlvfl 244 26 respectively respectively RB cord-007714-n3omlvfl 244 27 , , , cord-007714-n3omlvfl 244 28 in in IN cord-007714-n3omlvfl 244 29 yeast yeast NN cord-007714-n3omlvfl 244 30 ) ) -RRB- cord-007714-n3omlvfl 244 31 as as IN cord-007714-n3omlvfl 244 32 part part NN cord-007714-n3omlvfl 244 33 of of IN cord-007714-n3omlvfl 244 34 the the DT cord-007714-n3omlvfl 244 35 mRNP mrnp JJ cord-007714-n3omlvfl 244 36 complex complex NN cord-007714-n3omlvfl 244 37 which which WDT cord-007714-n3omlvfl 244 38 interacts interact VBZ cord-007714-n3omlvfl 244 39 with with IN cord-007714-n3omlvfl 244 40 the the DT cord-007714-n3omlvfl 244 41 export export NN cord-007714-n3omlvfl 244 42 receptor receptor NN cord-007714-n3omlvfl 244 43 protein protein NN cord-007714-n3omlvfl 244 44 TAP tap NN cord-007714-n3omlvfl 244 45 ( ( -LRB- cord-007714-n3omlvfl 244 46 Mex67p Mex67p NNP cord-007714-n3omlvfl 244 47 in in IN cord-007714-n3omlvfl 244 48 yeast yeast NN cord-007714-n3omlvfl 244 49 ) ) -RRB- cord-007714-n3omlvfl 244 50 ( ( -LRB- cord-007714-n3omlvfl 244 51 see see VB cord-007714-n3omlvfl 244 52 the the DT cord-007714-n3omlvfl 244 53 chapter chapter NN cord-007714-n3omlvfl 244 54 by by IN cord-007714-n3omlvfl 244 55 V. V. NNP cord-007714-n3omlvfl 244 56 Chinnusamy Chinnusamy NNP cord-007714-n3omlvfl 244 57 et et NNP cord-007714-n3omlvfl 244 58 al al NNP cord-007714-n3omlvfl 244 59 . . NNP cord-007714-n3omlvfl 244 60 , , , cord-007714-n3omlvfl 244 61 this this DT cord-007714-n3omlvfl 244 62 volume volume NN cord-007714-n3omlvfl 244 63 ) ) -RRB- cord-007714-n3omlvfl 244 64 . . . cord-007714-n3omlvfl 245 1 This this DT cord-007714-n3omlvfl 245 2 , , , cord-007714-n3omlvfl 245 3 in in IN cord-007714-n3omlvfl 245 4 turn turn NN cord-007714-n3omlvfl 245 5 , , , cord-007714-n3omlvfl 245 6 interacts interact VBZ cord-007714-n3omlvfl 245 7 with with IN cord-007714-n3omlvfl 245 8 components component NNS cord-007714-n3omlvfl 245 9 of of IN cord-007714-n3omlvfl 245 10 the the DT cord-007714-n3omlvfl 245 11 nuclear nuclear JJ cord-007714-n3omlvfl 245 12 pore pore NN cord-007714-n3omlvfl 245 13 complex complex NN cord-007714-n3omlvfl 245 14 ( ( -LRB- cord-007714-n3omlvfl 245 15 Reed Reed NNP cord-007714-n3omlvfl 245 16 and and CC cord-007714-n3omlvfl 245 17 Hurt Hurt NNP cord-007714-n3omlvfl 245 18 2002 2002 CD cord-007714-n3omlvfl 245 19 ; ; : cord-007714-n3omlvfl 245 20 Stutz Stutz NNP cord-007714-n3omlvfl 245 21 and and CC cord-007714-n3omlvfl 245 22 Izaurralde Izaurralde NNP cord-007714-n3omlvfl 245 23 2003 2003 CD cord-007714-n3omlvfl 245 24 ; ; : cord-007714-n3omlvfl 245 25 Aguilera Aguilera NNP cord-007714-n3omlvfl 245 26 2005 2005 CD cord-007714-n3omlvfl 245 27 ; ; : cord-007714-n3omlvfl 245 28 Reed Reed NNP cord-007714-n3omlvfl 245 29 and and CC cord-007714-n3omlvfl 245 30 Cheng Cheng NNP cord-007714-n3omlvfl 245 31 2005 2005 CD cord-007714-n3omlvfl 245 32 ) ) -RRB- cord-007714-n3omlvfl 245 33 . . . cord-007714-n3omlvfl 246 1 In in IN cord-007714-n3omlvfl 246 2 yeast yeast NN cord-007714-n3omlvfl 246 3 , , , cord-007714-n3omlvfl 246 4 all all DT cord-007714-n3omlvfl 246 5 three three CD cord-007714-n3omlvfl 246 6 proteins protein NNS cord-007714-n3omlvfl 246 7 ( ( -LRB- cord-007714-n3omlvfl 246 8 Mex67p Mex67p NNP cord-007714-n3omlvfl 246 9 , , , cord-007714-n3omlvfl 246 10 Yra1p yra1p NN cord-007714-n3omlvfl 246 11 and and CC cord-007714-n3omlvfl 246 12 Sub2p Sub2p NNP cord-007714-n3omlvfl 246 13 ) ) -RRB- cord-007714-n3omlvfl 246 14 are be VBP cord-007714-n3omlvfl 246 15 required require VBN cord-007714-n3omlvfl 246 16 for for IN cord-007714-n3omlvfl 246 17 export export NN cord-007714-n3omlvfl 246 18 , , , cord-007714-n3omlvfl 246 19 but but CC cord-007714-n3omlvfl 246 20 in in IN cord-007714-n3omlvfl 246 21 Drosophila Drosophila NNP cord-007714-n3omlvfl 246 22 and and CC cord-007714-n3omlvfl 246 23 Caenorhabiditis Caenorhabiditis NNP cord-007714-n3omlvfl 246 24 elegans elegan NNS cord-007714-n3omlvfl 246 25 Aly Aly NNP cord-007714-n3omlvfl 246 26 / / SYM cord-007714-n3omlvfl 246 27 REF REF NNP cord-007714-n3omlvfl 246 28 is be VBZ cord-007714-n3omlvfl 246 29 non non JJ cord-007714-n3omlvfl 246 30 - - JJ cord-007714-n3omlvfl 246 31 essential essential JJ cord-007714-n3omlvfl 246 32 ( ( -LRB- cord-007714-n3omlvfl 246 33 Gatfield Gatfield NNP cord-007714-n3omlvfl 246 34 and and CC cord-007714-n3omlvfl 246 35 Izaurralde Izaurralde NNP cord-007714-n3omlvfl 246 36 2002 2002 CD cord-007714-n3omlvfl 246 37 ; ; : cord-007714-n3omlvfl 246 38 Longmann Longmann NNP cord-007714-n3omlvfl 246 39 et et NNP cord-007714-n3omlvfl 246 40 al al NNP cord-007714-n3omlvfl 246 41 . . . cord-007714-n3omlvfl 246 42 2003 2003 CD cord-007714-n3omlvfl 247 1 ; ; : cord-007714-n3omlvfl 247 2 MacMorris MacMorris NNP cord-007714-n3omlvfl 247 3 et et NNP cord-007714-n3omlvfl 247 4 al al NNP cord-007714-n3omlvfl 247 5 . . NNP cord-007714-n3omlvfl 247 6 2003 2003 CD cord-007714-n3omlvfl 247 7 ) ) -RRB- cord-007714-n3omlvfl 247 8 . . . cord-007714-n3omlvfl 248 1 This this DT cord-007714-n3omlvfl 248 2 may may MD cord-007714-n3omlvfl 248 3 reflect reflect VB cord-007714-n3omlvfl 248 4 the the DT cord-007714-n3omlvfl 248 5 ability ability NN cord-007714-n3omlvfl 248 6 of of IN cord-007714-n3omlvfl 248 7 arginine arginine NN cord-007714-n3omlvfl 248 8 - - HYPH cord-007714-n3omlvfl 248 9 serine serine NN cord-007714-n3omlvfl 248 10 - - HYPH cord-007714-n3omlvfl 248 11 rich rich JJ cord-007714-n3omlvfl 248 12 ( ( -LRB- cord-007714-n3omlvfl 248 13 SR SR NNP cord-007714-n3omlvfl 248 14 ) ) -RRB- cord-007714-n3omlvfl 248 15 protein protein NN cord-007714-n3omlvfl 248 16 splicing splicing NN cord-007714-n3omlvfl 248 17 factors factor NNS cord-007714-n3omlvfl 248 18 to to TO cord-007714-n3omlvfl 248 19 interact interact VB cord-007714-n3omlvfl 248 20 with with IN cord-007714-n3omlvfl 248 21 TAP TAP NNP cord-007714-n3omlvfl 248 22 and and CC cord-007714-n3omlvfl 248 23 act act VB cord-007714-n3omlvfl 248 24 as as IN cord-007714-n3omlvfl 248 25 alternative alternative JJ cord-007714-n3omlvfl 248 26 export export NN cord-007714-n3omlvfl 248 27 adaptors adaptor NNS cord-007714-n3omlvfl 248 28 ( ( -LRB- cord-007714-n3omlvfl 248 29 Reed Reed NNP cord-007714-n3omlvfl 248 30 and and CC cord-007714-n3omlvfl 248 31 Cheng Cheng NNP cord-007714-n3omlvfl 248 32 2005 2005 CD cord-007714-n3omlvfl 248 33 ) ) -RRB- cord-007714-n3omlvfl 248 34 . . . cord-007714-n3omlvfl 249 1 Little little JJ cord-007714-n3omlvfl 249 2 is be VBZ cord-007714-n3omlvfl 249 3 known know VBN cord-007714-n3omlvfl 249 4 about about IN cord-007714-n3omlvfl 249 5 mRNA mRNA NNP cord-007714-n3omlvfl 249 6 export export NN cord-007714-n3omlvfl 249 7 components component NNS cord-007714-n3omlvfl 249 8 and and CC cord-007714-n3omlvfl 249 9 pathways pathway NNS cord-007714-n3omlvfl 249 10 in in IN cord-007714-n3omlvfl 249 11 plants plant NNS cord-007714-n3omlvfl 249 12 . . . cord-007714-n3omlvfl 250 1 In in IN cord-007714-n3omlvfl 250 2 particular particular JJ cord-007714-n3omlvfl 250 3 , , , cord-007714-n3omlvfl 250 4 it -PRON- PRP cord-007714-n3omlvfl 250 5 is be VBZ cord-007714-n3omlvfl 250 6 not not RB cord-007714-n3omlvfl 250 7 known know VBN cord-007714-n3omlvfl 250 8 whether whether IN cord-007714-n3omlvfl 250 9 Aly Aly NNP cord-007714-n3omlvfl 250 10 / / SYM cord-007714-n3omlvfl 250 11 REF REF NNP cord-007714-n3omlvfl 250 12 or or CC cord-007714-n3omlvfl 250 13 UAP56 UAP56 NNP cord-007714-n3omlvfl 250 14 is be VBZ cord-007714-n3omlvfl 250 15 needed need VBN cord-007714-n3omlvfl 250 16 for for IN cord-007714-n3omlvfl 250 17 mRNA mRNA NNP cord-007714-n3omlvfl 250 18 export export NN cord-007714-n3omlvfl 250 19 and and CC cord-007714-n3omlvfl 250 20 only only RB cord-007714-n3omlvfl 250 21 recently recently RB cord-007714-n3omlvfl 250 22 has have VBZ cord-007714-n3omlvfl 250 23 a a DT cord-007714-n3omlvfl 250 24 possible possible JJ cord-007714-n3omlvfl 250 25 orthologue orthologue NN cord-007714-n3omlvfl 250 26 of of IN cord-007714-n3omlvfl 250 27 TAP TAP NNP cord-007714-n3omlvfl 250 28 has have VBZ cord-007714-n3omlvfl 250 29 been be VBN cord-007714-n3omlvfl 250 30 identified identify VBN cord-007714-n3omlvfl 251 1 ( ( -LRB- cord-007714-n3omlvfl 251 2 Hernandez Hernandez NNP cord-007714-n3omlvfl 251 3 - - HYPH cord-007714-n3omlvfl 251 4 Pinzon Pinzon NNP cord-007714-n3omlvfl 251 5 et et NNP cord-007714-n3omlvfl 251 6 al al NNP cord-007714-n3omlvfl 251 7 . . NNP cord-007714-n3omlvfl 251 8 2007 2007 CD cord-007714-n3omlvfl 251 9 ) ) -RRB- cord-007714-n3omlvfl 251 10 . . . cord-007714-n3omlvfl 252 1 Nevertheless nevertheless RB cord-007714-n3omlvfl 252 2 , , , cord-007714-n3omlvfl 252 3 three three CD cord-007714-n3omlvfl 252 4 of of IN cord-007714-n3omlvfl 252 5 the the DT cord-007714-n3omlvfl 252 6 four four CD cord-007714-n3omlvfl 252 7 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 252 8 Aly Aly NNP cord-007714-n3omlvfl 252 9 / / SYM cord-007714-n3omlvfl 252 10 REF REF NNP cord-007714-n3omlvfl 252 11 proteins protein NNS cord-007714-n3omlvfl 252 12 and and CC cord-007714-n3omlvfl 252 13 UAP56 uap56 RB cord-007714-n3omlvfl 252 14 localise localise VB cord-007714-n3omlvfl 252 15 strongly strongly RB cord-007714-n3omlvfl 252 16 to to IN cord-007714-n3omlvfl 252 17 the the DT cord-007714-n3omlvfl 252 18 nucleolus nucleolus NN cord-007714-n3omlvfl 252 19 ( ( -LRB- cord-007714-n3omlvfl 252 20 Pendle Pendle NNP cord-007714-n3omlvfl 252 21 et et NNP cord-007714-n3omlvfl 252 22 al al NNP cord-007714-n3omlvfl 252 23 . . NNP cord-007714-n3omlvfl 252 24 2005 2005 CD cord-007714-n3omlvfl 252 25 ) ) -RRB- cord-007714-n3omlvfl 252 26 and and CC cord-007714-n3omlvfl 252 27 both both DT cord-007714-n3omlvfl 252 28 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 252 29 and and CC cord-007714-n3omlvfl 252 30 tobacco tobacco NN cord-007714-n3omlvfl 252 31 Aly Aly NNP cord-007714-n3omlvfl 252 32 proteins protein NNS cord-007714-n3omlvfl 252 33 shuttle shuttle NN cord-007714-n3omlvfl 252 34 between between IN cord-007714-n3omlvfl 252 35 the the DT cord-007714-n3omlvfl 252 36 nucleolus nucleolus NN cord-007714-n3omlvfl 252 37 / / SYM cord-007714-n3omlvfl 252 38 nucleus nucleus NN cord-007714-n3omlvfl 252 39 and and CC cord-007714-n3omlvfl 252 40 cytoplasm cytoplasm JJ cord-007714-n3omlvfl 253 1 ( ( -LRB- cord-007714-n3omlvfl 253 2 Uhrig Uhrig NNP cord-007714-n3omlvfl 253 3 et et NNP cord-007714-n3omlvfl 253 4 al al NNP cord-007714-n3omlvfl 253 5 . . . cord-007714-n3omlvfl 254 1 2004 2004 CD cord-007714-n3omlvfl 254 2 ; ; : cord-007714-n3omlvfl 254 3 Canto Canto NNP cord-007714-n3omlvfl 254 4 et et NNP cord-007714-n3omlvfl 254 5 al al NNP cord-007714-n3omlvfl 254 6 . . . cord-007714-n3omlvfl 254 7 2006 2006 CD cord-007714-n3omlvfl 254 8 ) ) -RRB- cord-007714-n3omlvfl 254 9 . . . cord-007714-n3omlvfl 255 1 In in IN cord-007714-n3omlvfl 255 2 addition addition NN cord-007714-n3omlvfl 255 3 , , , cord-007714-n3omlvfl 255 4 besides besides IN cord-007714-n3omlvfl 255 5 EJC EJC NNP cord-007714-n3omlvfl 255 6 proteins protein NNS cord-007714-n3omlvfl 255 7 , , , cord-007714-n3omlvfl 255 8 some some DT cord-007714-n3omlvfl 255 9 splicing splicing NN cord-007714-n3omlvfl 255 10 factors factor NNS cord-007714-n3omlvfl 255 11 ( ( -LRB- cord-007714-n3omlvfl 255 12 including include VBG cord-007714-n3omlvfl 255 13 SR SR NNP cord-007714-n3omlvfl 255 14 proteins protein NNS cord-007714-n3omlvfl 255 15 ) ) -RRB- cord-007714-n3omlvfl 255 16 , , , cord-007714-n3omlvfl 255 17 spliceosomal spliceosomal NNP cord-007714-n3omlvfl 255 18 snRNP snrnp NN cord-007714-n3omlvfl 255 19 proteins protein NNS cord-007714-n3omlvfl 255 20 and and CC cord-007714-n3omlvfl 255 21 hnRNP hnrnp DT cord-007714-n3omlvfl 255 22 proteins protein NNS cord-007714-n3omlvfl 255 23 were be VBD cord-007714-n3omlvfl 255 24 identified identify VBN cord-007714-n3omlvfl 255 25 in in IN cord-007714-n3omlvfl 255 26 the the DT cord-007714-n3omlvfl 255 27 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 255 28 nucleolar nucleolar NN cord-007714-n3omlvfl 255 29 proteome proteome NN cord-007714-n3omlvfl 255 30 ( ( -LRB- cord-007714-n3omlvfl 255 31 Pendle Pendle NNP cord-007714-n3omlvfl 255 32 et et NNP cord-007714-n3omlvfl 255 33 al al NNP cord-007714-n3omlvfl 255 34 . . NNP cord-007714-n3omlvfl 255 35 2005 2005 CD cord-007714-n3omlvfl 255 36 ) ) -RRB- cord-007714-n3omlvfl 255 37 and and CC cord-007714-n3omlvfl 255 38 the the DT cord-007714-n3omlvfl 255 39 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 255 40 SR SR NNP cord-007714-n3omlvfl 255 41 protein protein NN cord-007714-n3omlvfl 255 42 RSZ22 RSZ22 NNP cord-007714-n3omlvfl 255 43 has have VBZ cord-007714-n3omlvfl 255 44 recently recently RB cord-007714-n3omlvfl 255 45 been be VBN cord-007714-n3omlvfl 255 46 shown show VBN cord-007714-n3omlvfl 255 47 to to IN cord-007714-n3omlvfl 255 48 shuttle shuttle NN cord-007714-n3omlvfl 255 49 between between IN cord-007714-n3omlvfl 255 50 the the DT cord-007714-n3omlvfl 255 51 nucleoplasm nucleoplasm NN cord-007714-n3omlvfl 255 52 , , , cord-007714-n3omlvfl 255 53 nuclear nuclear JJ cord-007714-n3omlvfl 255 54 speckles speckle NNS cord-007714-n3omlvfl 255 55 and and CC cord-007714-n3omlvfl 255 56 the the DT cord-007714-n3omlvfl 255 57 nucleolus nucleolus NN cord-007714-n3omlvfl 256 1 ( ( -LRB- cord-007714-n3omlvfl 256 2 Tillemans Tillemans NNP cord-007714-n3omlvfl 256 3 et et NNP cord-007714-n3omlvfl 256 4 al al NNP cord-007714-n3omlvfl 256 5 . . . cord-007714-n3omlvfl 256 6 2006 2006 CD cord-007714-n3omlvfl 256 7 ) ) -RRB- cord-007714-n3omlvfl 256 8 . . . cord-007714-n3omlvfl 257 1 These these DT cord-007714-n3omlvfl 257 2 observations observation NNS cord-007714-n3omlvfl 257 3 are be VBP cord-007714-n3omlvfl 257 4 consistent consistent JJ cord-007714-n3omlvfl 257 5 with with IN cord-007714-n3omlvfl 257 6 the the DT cord-007714-n3omlvfl 257 7 involvement involvement NN cord-007714-n3omlvfl 257 8 of of IN cord-007714-n3omlvfl 257 9 the the DT cord-007714-n3omlvfl 257 10 nucleolus nucleolus NN cord-007714-n3omlvfl 257 11 with with IN cord-007714-n3omlvfl 257 12 mRNA mRNA NNP cord-007714-n3omlvfl 257 13 export export NN cord-007714-n3omlvfl 257 14 . . . cord-007714-n3omlvfl 258 1 The the DT cord-007714-n3omlvfl 258 2 potential potential JJ cord-007714-n3omlvfl 258 3 export export NN cord-007714-n3omlvfl 258 4 of of IN cord-007714-n3omlvfl 258 5 mRNAs mRNAs NNPS cord-007714-n3omlvfl 258 6 via via IN cord-007714-n3omlvfl 258 7 the the DT cord-007714-n3omlvfl 258 8 nucleolus nucleolus NN cord-007714-n3omlvfl 258 9 parallels parallel VBZ cord-007714-n3omlvfl 258 10 studies study NNS cord-007714-n3omlvfl 258 11 of of IN cord-007714-n3omlvfl 258 12 viral viral JJ cord-007714-n3omlvfl 258 13 RNA RNA NNP cord-007714-n3omlvfl 258 14 export export NN cord-007714-n3omlvfl 258 15 in in IN cord-007714-n3omlvfl 258 16 mammals mammal NNS cord-007714-n3omlvfl 258 17 . . . cord-007714-n3omlvfl 259 1 The the DT cord-007714-n3omlvfl 259 2 export export NN cord-007714-n3omlvfl 259 3 of of IN cord-007714-n3omlvfl 259 4 herpesvirus herpesvirus NNP cord-007714-n3omlvfl 259 5 saimiri saimiri NNP cord-007714-n3omlvfl 259 6 ( ( -LRB- cord-007714-n3omlvfl 259 7 HVS HVS NNP cord-007714-n3omlvfl 259 8 ) ) -RRB- cord-007714-n3omlvfl 259 9 mRNA mRNA NNP cord-007714-n3omlvfl 259 10 involves involve VBZ cord-007714-n3omlvfl 259 11 the the DT cord-007714-n3omlvfl 259 12 expression expression NN cord-007714-n3omlvfl 259 13 of of IN cord-007714-n3omlvfl 259 14 the the DT cord-007714-n3omlvfl 259 15 viral viral JJ cord-007714-n3omlvfl 259 16 ORF57 ORF57 NNP cord-007714-n3omlvfl 259 17 protein protein NN cord-007714-n3omlvfl 259 18 which which WDT cord-007714-n3omlvfl 259 19 causes cause VBZ cord-007714-n3omlvfl 259 20 Aly Aly NNP cord-007714-n3omlvfl 259 21 , , , cord-007714-n3omlvfl 259 22 UAP56 uap56 JJ cord-007714-n3omlvfl 259 23 and and CC cord-007714-n3omlvfl 259 24 other other JJ cord-007714-n3omlvfl 259 25 human human JJ cord-007714-n3omlvfl 259 26 export export NN cord-007714-n3omlvfl 259 27 factors factor NNS cord-007714-n3omlvfl 259 28 to to TO cord-007714-n3omlvfl 259 29 be be VB cord-007714-n3omlvfl 259 30 redistributed redistribute VBN cord-007714-n3omlvfl 259 31 to to IN cord-007714-n3omlvfl 259 32 the the DT cord-007714-n3omlvfl 259 33 nucleolus nucleolus NN cord-007714-n3omlvfl 259 34 ( ( -LRB- cord-007714-n3omlvfl 259 35 Boyne Boyne NNP cord-007714-n3omlvfl 259 36 and and CC cord-007714-n3omlvfl 259 37 Whitehouse Whitehouse NNP cord-007714-n3omlvfl 259 38 2006 2006 CD cord-007714-n3omlvfl 259 39 ) ) -RRB- cord-007714-n3omlvfl 259 40 . . . cord-007714-n3omlvfl 260 1 ORF57 ORF57 NNP cord-007714-n3omlvfl 260 2 is be VBZ cord-007714-n3omlvfl 260 3 a a DT cord-007714-n3omlvfl 260 4 nucleocytoplasmic nucleocytoplasmic NN cord-007714-n3omlvfl 260 5 shuttling shuttle VBG cord-007714-n3omlvfl 260 6 protein protein NN cord-007714-n3omlvfl 260 7 which which WDT cord-007714-n3omlvfl 260 8 binds bind VBZ cord-007714-n3omlvfl 260 9 viral viral JJ cord-007714-n3omlvfl 260 10 intronless intronless NN cord-007714-n3omlvfl 260 11 mRNAs mrnas CD cord-007714-n3omlvfl 260 12 and and CC cord-007714-n3omlvfl 260 13 , , , cord-007714-n3omlvfl 260 14 by by IN cord-007714-n3omlvfl 260 15 interacting interact VBG cord-007714-n3omlvfl 260 16 with with IN cord-007714-n3omlvfl 260 17 Aly Aly NNP cord-007714-n3omlvfl 260 18 and and CC cord-007714-n3omlvfl 260 19 the the DT cord-007714-n3omlvfl 260 20 transcription transcription NN cord-007714-n3omlvfl 260 21 / / SYM cord-007714-n3omlvfl 260 22 export export NN cord-007714-n3omlvfl 260 23 complex complex NN cord-007714-n3omlvfl 260 24 ( ( -LRB- cord-007714-n3omlvfl 260 25 TREX TREX NNP cord-007714-n3omlvfl 260 26 ) ) -RRB- cord-007714-n3omlvfl 260 27 , , , cord-007714-n3omlvfl 260 28 accesses access VBZ cord-007714-n3omlvfl 260 29 TAP tap NN cord-007714-n3omlvfl 260 30 - - HYPH cord-007714-n3omlvfl 260 31 mediated mediate VBN cord-007714-n3omlvfl 260 32 export export NN cord-007714-n3omlvfl 260 33 ( ( -LRB- cord-007714-n3omlvfl 260 34 Williams Williams NNP cord-007714-n3omlvfl 260 35 et et NNP cord-007714-n3omlvfl 260 36 al al NNP cord-007714-n3omlvfl 260 37 . . NNP cord-007714-n3omlvfl 260 38 2005 2005 CD cord-007714-n3omlvfl 260 39 ) ) -RRB- cord-007714-n3omlvfl 260 40 . . . cord-007714-n3omlvfl 261 1 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 261 2 trafficking trafficking NN cord-007714-n3omlvfl 261 3 of of IN cord-007714-n3omlvfl 261 4 ORF57 ORF57 NNP cord-007714-n3omlvfl 261 5 is be VBZ cord-007714-n3omlvfl 261 6 essential essential JJ cord-007714-n3omlvfl 261 7 for for IN cord-007714-n3omlvfl 261 8 efficient efficient JJ cord-007714-n3omlvfl 261 9 export export NN cord-007714-n3omlvfl 261 10 of of IN cord-007714-n3omlvfl 261 11 the the DT cord-007714-n3omlvfl 261 12 viral viral NN cord-007714-n3omlvfl 261 13 mRNAs mRNAs . cord-007714-n3omlvfl 262 1 ( ( -LRB- cord-007714-n3omlvfl 262 2 Boyne Boyne NNP cord-007714-n3omlvfl 262 3 and and CC cord-007714-n3omlvfl 262 4 Whitehouse Whitehouse NNP cord-007714-n3omlvfl 262 5 2006 2006 CD cord-007714-n3omlvfl 262 6 ) ) -RRB- cord-007714-n3omlvfl 262 7 . . . cord-007714-n3omlvfl 263 1 Similarly similarly RB cord-007714-n3omlvfl 263 2 , , , cord-007714-n3omlvfl 263 3 the the DT cord-007714-n3omlvfl 263 4 human human JJ cord-007714-n3omlvfl 263 5 immunodeficiency immunodeficiency NN cord-007714-n3omlvfl 263 6 virus virus NN cord-007714-n3omlvfl 263 7 type type NN cord-007714-n3omlvfl 263 8 1 1 CD cord-007714-n3omlvfl 263 9 ( ( -LRB- cord-007714-n3omlvfl 263 10 HIV-1 HIV-1 NNP cord-007714-n3omlvfl 263 11 ) ) -RRB- cord-007714-n3omlvfl 263 12 exports export NNS cord-007714-n3omlvfl 263 13 unspliced unsplice VBN cord-007714-n3omlvfl 263 14 and and CC cord-007714-n3omlvfl 263 15 singly singly RB cord-007714-n3omlvfl 263 16 spliced splice VBN cord-007714-n3omlvfl 263 17 viral viral JJ cord-007714-n3omlvfl 263 18 mRNAs mrnas TO cord-007714-n3omlvfl 263 19 via via IN cord-007714-n3omlvfl 263 20 the the DT cord-007714-n3omlvfl 263 21 nucleolus nucleolus NN cord-007714-n3omlvfl 263 22 for for IN cord-007714-n3omlvfl 263 23 replication replication NN cord-007714-n3omlvfl 263 24 ( ( -LRB- cord-007714-n3omlvfl 263 25 Michienzi Michienzi NNP cord-007714-n3omlvfl 263 26 et et NNP cord-007714-n3omlvfl 263 27 al al NNP cord-007714-n3omlvfl 263 28 . . . cord-007714-n3omlvfl 264 1 2000 2000 CD cord-007714-n3omlvfl 264 2 ; ; : cord-007714-n3omlvfl 264 3 Hiscox Hiscox NNP cord-007714-n3omlvfl 264 4 2007 2007 CD cord-007714-n3omlvfl 264 5 ) ) -RRB- cord-007714-n3omlvfl 264 6 . . . cord-007714-n3omlvfl 265 1 The the DT cord-007714-n3omlvfl 265 2 virus virus NN cord-007714-n3omlvfl 265 3 - - HYPH cord-007714-n3omlvfl 265 4 encoded encode VBN cord-007714-n3omlvfl 265 5 protein protein NN cord-007714-n3omlvfl 265 6 Rev Rev NNP cord-007714-n3omlvfl 265 7 is be VBZ cord-007714-n3omlvfl 265 8 a a DT cord-007714-n3omlvfl 265 9 nucleocytoplasmic nucleocytoplasmic NN cord-007714-n3omlvfl 265 10 shuttling shuttle VBG cord-007714-n3omlvfl 265 11 protein protein NN cord-007714-n3omlvfl 265 12 which which WDT cord-007714-n3omlvfl 265 13 accumulates accumulate VBZ cord-007714-n3omlvfl 265 14 in in IN cord-007714-n3omlvfl 265 15 the the DT cord-007714-n3omlvfl 265 16 nucleolus nucleolus NN cord-007714-n3omlvfl 265 17 . . . cord-007714-n3omlvfl 266 1 It -PRON- PRP cord-007714-n3omlvfl 266 2 interacts interact VBZ cord-007714-n3omlvfl 266 3 with with IN cord-007714-n3omlvfl 266 4 the the DT cord-007714-n3omlvfl 266 5 export export NN cord-007714-n3omlvfl 266 6 factor factor NN cord-007714-n3omlvfl 266 7 CRM1 CRM1 NNP cord-007714-n3omlvfl 266 8 and and CC cord-007714-n3omlvfl 266 9 particular particular JJ cord-007714-n3omlvfl 266 10 nucleoporins nucleoporin NNS cord-007714-n3omlvfl 266 11 , , , cord-007714-n3omlvfl 266 12 causing cause VBG cord-007714-n3omlvfl 266 13 their -PRON- PRP$ cord-007714-n3omlvfl 266 14 relocalisation relocalisation NN cord-007714-n3omlvfl 266 15 to to IN cord-007714-n3omlvfl 266 16 the the DT cord-007714-n3omlvfl 266 17 nucleolus nucleolus NN cord-007714-n3omlvfl 266 18 . . . cord-007714-n3omlvfl 267 1 By by IN cord-007714-n3omlvfl 267 2 binding bind VBG cord-007714-n3omlvfl 267 3 a a DT cord-007714-n3omlvfl 267 4 specific specific JJ cord-007714-n3omlvfl 267 5 sequence sequence NN cord-007714-n3omlvfl 267 6 in in IN cord-007714-n3omlvfl 267 7 viral viral JJ cord-007714-n3omlvfl 267 8 unspliced unspliced JJ cord-007714-n3omlvfl 267 9 mRNAs mRNAs NNPS cord-007714-n3omlvfl 267 10 and and CC cord-007714-n3omlvfl 267 11 interacting interact VBG cord-007714-n3omlvfl 267 12 with with IN cord-007714-n3omlvfl 267 13 CRM1 CRM1 NNP cord-007714-n3omlvfl 267 14 and and CC cord-007714-n3omlvfl 267 15 the the DT cord-007714-n3omlvfl 267 16 nucleoporins nucleoporin NNS cord-007714-n3omlvfl 267 17 , , , cord-007714-n3omlvfl 267 18 it -PRON- PRP cord-007714-n3omlvfl 267 19 is be VBZ cord-007714-n3omlvfl 267 20 thought think VBN cord-007714-n3omlvfl 267 21 to to TO cord-007714-n3omlvfl 267 22 assemble assemble VB cord-007714-n3omlvfl 267 23 an an DT cord-007714-n3omlvfl 267 24 export export NN cord-007714-n3omlvfl 267 25 - - HYPH cord-007714-n3omlvfl 267 26 competent competent JJ cord-007714-n3omlvfl 267 27 complex complex NN cord-007714-n3omlvfl 267 28 in in IN cord-007714-n3omlvfl 267 29 the the DT cord-007714-n3omlvfl 267 30 nucleolus nucleolus NN cord-007714-n3omlvfl 267 31 ( ( -LRB- cord-007714-n3omlvfl 268 1 Hope hope NN cord-007714-n3omlvfl 268 2 1999 1999 CD cord-007714-n3omlvfl 268 3 ) ) -RRB- cord-007714-n3omlvfl 268 4 . . . cord-007714-n3omlvfl 269 1 Thus thus RB cord-007714-n3omlvfl 269 2 these these DT cord-007714-n3omlvfl 269 3 viral viral JJ cord-007714-n3omlvfl 269 4 mRNAs mRNAs NNPS cord-007714-n3omlvfl 269 5 are be VBP cord-007714-n3omlvfl 269 6 targeted target VBN cord-007714-n3omlvfl 269 7 to to IN cord-007714-n3omlvfl 269 8 the the DT cord-007714-n3omlvfl 269 9 nucleolus nucleolus NN cord-007714-n3omlvfl 269 10 , , , cord-007714-n3omlvfl 269 11 where where WRB cord-007714-n3omlvfl 269 12 they -PRON- PRP cord-007714-n3omlvfl 269 13 associate associate VBP cord-007714-n3omlvfl 269 14 with with IN cord-007714-n3omlvfl 269 15 export export NN cord-007714-n3omlvfl 269 16 factors factor NNS cord-007714-n3omlvfl 269 17 and and CC cord-007714-n3omlvfl 269 18 are be VBP cord-007714-n3omlvfl 269 19 exported export VBN cord-007714-n3omlvfl 269 20 . . . cord-007714-n3omlvfl 270 1 These these DT cord-007714-n3omlvfl 270 2 pathways pathway NNS cord-007714-n3omlvfl 270 3 may may MD cord-007714-n3omlvfl 270 4 represent represent VB cord-007714-n3omlvfl 270 5 an an DT cord-007714-n3omlvfl 270 6 inherent inherent JJ cord-007714-n3omlvfl 270 7 eukaryotic eukaryotic JJ cord-007714-n3omlvfl 270 8 nucleolar nucleolar NNP cord-007714-n3omlvfl 270 9 mRNA mRNA NNP cord-007714-n3omlvfl 270 10 export export NN cord-007714-n3omlvfl 270 11 pathway pathway NN cord-007714-n3omlvfl 270 12 , , , cord-007714-n3omlvfl 270 13 which which WDT cord-007714-n3omlvfl 270 14 is be VBZ cord-007714-n3omlvfl 270 15 exploited exploit VBN cord-007714-n3omlvfl 270 16 by by IN cord-007714-n3omlvfl 270 17 these these DT cord-007714-n3omlvfl 270 18 viruses virus NNS cord-007714-n3omlvfl 270 19 . . . cord-007714-n3omlvfl 271 1 The the DT cord-007714-n3omlvfl 271 2 importance importance NN cord-007714-n3omlvfl 271 3 of of IN cord-007714-n3omlvfl 271 4 mRNA mRNA NNP cord-007714-n3omlvfl 271 5 export export NN cord-007714-n3omlvfl 271 6 in in IN cord-007714-n3omlvfl 271 7 abiotic abiotic JJ cord-007714-n3omlvfl 271 8 stress stress NN cord-007714-n3omlvfl 271 9 responses response NNS cord-007714-n3omlvfl 271 10 is be VBZ cord-007714-n3omlvfl 271 11 reviewed review VBN cord-007714-n3omlvfl 271 12 in in IN cord-007714-n3omlvfl 271 13 the the DT cord-007714-n3omlvfl 271 14 chapter chapter NN cord-007714-n3omlvfl 271 15 by by IN cord-007714-n3omlvfl 271 16 V. V. NNP cord-007714-n3omlvfl 271 17 Chinnusamy Chinnusamy NNP cord-007714-n3omlvfl 271 18 et et NNP cord-007714-n3omlvfl 271 19 al al NNP cord-007714-n3omlvfl 271 20 . . . cord-007714-n3omlvfl 272 1 ( ( -LRB- cord-007714-n3omlvfl 272 2 this this DT cord-007714-n3omlvfl 272 3 volume volume NN cord-007714-n3omlvfl 272 4 ) ) -RRB- cord-007714-n3omlvfl 272 5 . . . cord-007714-n3omlvfl 273 1 Eukaryotic eukaryotic JJ cord-007714-n3omlvfl 273 2 systems system NNS cord-007714-n3omlvfl 273 3 utilise utilise VBP cord-007714-n3omlvfl 273 4 NMD NMD NNP cord-007714-n3omlvfl 273 5 as as IN cord-007714-n3omlvfl 273 6 a a DT cord-007714-n3omlvfl 273 7 quality quality NN cord-007714-n3omlvfl 273 8 - - HYPH cord-007714-n3omlvfl 273 9 control control NN cord-007714-n3omlvfl 273 10 mechanism mechanism NN cord-007714-n3omlvfl 273 11 to to TO cord-007714-n3omlvfl 273 12 recognise recognise VB cord-007714-n3omlvfl 273 13 and and CC cord-007714-n3omlvfl 273 14 destroy destroy VB cord-007714-n3omlvfl 273 15 transcripts transcript NNS cord-007714-n3omlvfl 273 16 containing contain VBG cord-007714-n3omlvfl 273 17 PTCs ptc NNS cord-007714-n3omlvfl 273 18 ( ( -LRB- cord-007714-n3omlvfl 273 19 PTC+ PTC+ NNP cord-007714-n3omlvfl 273 20 transcripts transcript NNS cord-007714-n3omlvfl 273 21 ) ) -RRB- cord-007714-n3omlvfl 274 1 ( ( -LRB- cord-007714-n3omlvfl 274 2 Maquat Maquat NNP cord-007714-n3omlvfl 274 3 2004 2004 CD cord-007714-n3omlvfl 274 4 ; ; : cord-007714-n3omlvfl 274 5 Lejeune Lejeune NNP cord-007714-n3omlvfl 274 6 and and CC cord-007714-n3omlvfl 274 7 Maquat Maquat NNP cord-007714-n3omlvfl 274 8 2005 2005 CD cord-007714-n3omlvfl 274 9 ) ) -RRB- cord-007714-n3omlvfl 274 10 preventing prevent VBG cord-007714-n3omlvfl 274 11 the the DT cord-007714-n3omlvfl 274 12 formation formation NN cord-007714-n3omlvfl 274 13 of of IN cord-007714-n3omlvfl 274 14 truncated truncated JJ cord-007714-n3omlvfl 274 15 polypeptides polypeptide NNS cord-007714-n3omlvfl 274 16 which which WDT cord-007714-n3omlvfl 274 17 could could MD cord-007714-n3omlvfl 274 18 be be VB cord-007714-n3omlvfl 274 19 potentially potentially RB cord-007714-n3omlvfl 274 20 harmful harmful JJ cord-007714-n3omlvfl 274 21 for for IN cord-007714-n3omlvfl 274 22 the the DT cord-007714-n3omlvfl 274 23 cell cell NN cord-007714-n3omlvfl 274 24 by by IN cord-007714-n3omlvfl 274 25 acting act VBG cord-007714-n3omlvfl 274 26 as as IN cord-007714-n3omlvfl 274 27 dominant dominant JJ cord-007714-n3omlvfl 274 28 - - HYPH cord-007714-n3omlvfl 274 29 negative negative JJ cord-007714-n3omlvfl 274 30 mutations mutation NNS cord-007714-n3omlvfl 274 31 ( ( -LRB- cord-007714-n3omlvfl 274 32 see see VB cord-007714-n3omlvfl 274 33 the the DT cord-007714-n3omlvfl 274 34 chapter chapter NN cord-007714-n3omlvfl 274 35 by by IN cord-007714-n3omlvfl 274 36 D. D. NNP cord-007714-n3omlvfl 274 37 A. a. NN cord-007714-n3omlvfl 274 38 Belostotsky Belostotsky NNP cord-007714-n3omlvfl 274 39 , , , cord-007714-n3omlvfl 274 40 this this DT cord-007714-n3omlvfl 274 41 volume volume NN cord-007714-n3omlvfl 274 42 ) ) -RRB- cord-007714-n3omlvfl 274 43 . . . cord-007714-n3omlvfl 275 1 The the DT cord-007714-n3omlvfl 275 2 NMD NMD NNP cord-007714-n3omlvfl 275 3 pathway pathway NN cord-007714-n3omlvfl 275 4 has have VBZ cord-007714-n3omlvfl 275 5 been be VBN cord-007714-n3omlvfl 275 6 widely widely RB cord-007714-n3omlvfl 275 7 studied study VBN cord-007714-n3omlvfl 275 8 in in IN cord-007714-n3omlvfl 275 9 yeast yeast NN cord-007714-n3omlvfl 275 10 , , , cord-007714-n3omlvfl 275 11 Caenorhabiditis Caenorhabiditis NNP cord-007714-n3omlvfl 275 12 elegans elegan NNS cord-007714-n3omlvfl 275 13 , , , cord-007714-n3omlvfl 275 14 Drosophila Drosophila NNP cord-007714-n3omlvfl 275 15 and and CC cord-007714-n3omlvfl 275 16 humans human NNS cord-007714-n3omlvfl 275 17 and and CC cord-007714-n3omlvfl 275 18 there there EX cord-007714-n3omlvfl 275 19 are be VBP cord-007714-n3omlvfl 275 20 differences difference NNS cord-007714-n3omlvfl 275 21 in in IN cord-007714-n3omlvfl 275 22 components component NNS cord-007714-n3omlvfl 275 23 and and CC cord-007714-n3omlvfl 275 24 mechanisms mechanism NNS cord-007714-n3omlvfl 275 25 by by IN cord-007714-n3omlvfl 275 26 which which WDT cord-007714-n3omlvfl 275 27 PTCs ptc NNS cord-007714-n3omlvfl 275 28 are be VBP cord-007714-n3omlvfl 275 29 discriminated discriminate VBN cord-007714-n3omlvfl 275 30 ( ( -LRB- cord-007714-n3omlvfl 275 31 Culbertson Culbertson NNP cord-007714-n3omlvfl 275 32 and and CC cord-007714-n3omlvfl 275 33 Leeds Leeds NNP cord-007714-n3omlvfl 275 34 2003 2003 CD cord-007714-n3omlvfl 275 35 ; ; : cord-007714-n3omlvfl 275 36 Conti Conti NNP cord-007714-n3omlvfl 275 37 and and CC cord-007714-n3omlvfl 275 38 Izzuralde Izzuralde NNP cord-007714-n3omlvfl 275 39 2005 2005 CD cord-007714-n3omlvfl 275 40 ) ) -RRB- cord-007714-n3omlvfl 275 41 . . . cord-007714-n3omlvfl 276 1 In in IN cord-007714-n3omlvfl 276 2 mammals mammal NNS cord-007714-n3omlvfl 276 3 , , , cord-007714-n3omlvfl 276 4 PTC PTC NNP cord-007714-n3omlvfl 276 5 - - HYPH cord-007714-n3omlvfl 276 6 containing contain VBG cord-007714-n3omlvfl 276 7 transcripts transcript NNS cord-007714-n3omlvfl 276 8 have have VBP cord-007714-n3omlvfl 276 9 classically classically RB cord-007714-n3omlvfl 276 10 been be VBN cord-007714-n3omlvfl 276 11 thought think VBN cord-007714-n3omlvfl 276 12 to to TO cord-007714-n3omlvfl 276 13 be be VB cord-007714-n3omlvfl 276 14 targeted target VBN cord-007714-n3omlvfl 276 15 for for IN cord-007714-n3omlvfl 276 16 NMD NMD NNP cord-007714-n3omlvfl 276 17 by by IN cord-007714-n3omlvfl 276 18 the the DT cord-007714-n3omlvfl 276 19 interaction interaction NN cord-007714-n3omlvfl 276 20 of of IN cord-007714-n3omlvfl 276 21 a a DT cord-007714-n3omlvfl 276 22 paused pause VBN cord-007714-n3omlvfl 276 23 ribosome ribosome NN cord-007714-n3omlvfl 276 24 at at IN cord-007714-n3omlvfl 276 25 the the DT cord-007714-n3omlvfl 276 26 PTC PTC NNP cord-007714-n3omlvfl 276 27 with with IN cord-007714-n3omlvfl 276 28 a a DT cord-007714-n3omlvfl 276 29 downstream downstream JJ cord-007714-n3omlvfl 276 30 EJC EJC NNP cord-007714-n3omlvfl 276 31 ( ( -LRB- cord-007714-n3omlvfl 276 32 Maquat Maquat NNP cord-007714-n3omlvfl 276 33 2004 2004 CD cord-007714-n3omlvfl 276 34 ; ; : cord-007714-n3omlvfl 276 35 Lejeune Lejeune NNP cord-007714-n3omlvfl 276 36 and and CC cord-007714-n3omlvfl 276 37 Maquat Maquat NNP cord-007714-n3omlvfl 276 38 2005 2005 CD cord-007714-n3omlvfl 276 39 ) ) -RRB- cord-007714-n3omlvfl 276 40 . . . cord-007714-n3omlvfl 277 1 However however RB cord-007714-n3omlvfl 277 2 , , , cord-007714-n3omlvfl 277 3 recent recent JJ cord-007714-n3omlvfl 277 4 results result NNS cord-007714-n3omlvfl 277 5 suggest suggest VBP cord-007714-n3omlvfl 277 6 that that IN cord-007714-n3omlvfl 277 7 the the DT cord-007714-n3omlvfl 277 8 distance distance NN cord-007714-n3omlvfl 277 9 between between IN cord-007714-n3omlvfl 277 10 the the DT cord-007714-n3omlvfl 277 11 termination termination NN cord-007714-n3omlvfl 277 12 codon codon NN cord-007714-n3omlvfl 277 13 and and CC cord-007714-n3omlvfl 277 14 the the DT cord-007714-n3omlvfl 277 15 poly(A poly(a JJ cord-007714-n3omlvfl 277 16 ) ) -RRB- cord-007714-n3omlvfl 277 17 tail tail NN cord-007714-n3omlvfl 277 18 is be VBZ cord-007714-n3omlvfl 277 19 a a DT cord-007714-n3omlvfl 277 20 major major JJ cord-007714-n3omlvfl 277 21 determinant determinant NN cord-007714-n3omlvfl 277 22 of of IN cord-007714-n3omlvfl 277 23 NMD NMD NNP cord-007714-n3omlvfl 277 24 such such JJ cord-007714-n3omlvfl 277 25 that that IN cord-007714-n3omlvfl 277 26 premature premature JJ cord-007714-n3omlvfl 277 27 translation translation NN cord-007714-n3omlvfl 277 28 termination termination NN cord-007714-n3omlvfl 277 29 in in IN cord-007714-n3omlvfl 277 30 the the DT cord-007714-n3omlvfl 277 31 wrong wrong JJ cord-007714-n3omlvfl 277 32 mRNP mrnp NN cord-007714-n3omlvfl 277 33 context context NN cord-007714-n3omlvfl 277 34 , , , cord-007714-n3omlvfl 277 35 possibly possibly RB cord-007714-n3omlvfl 277 36 through through IN cord-007714-n3omlvfl 277 37 interaction interaction NN cord-007714-n3omlvfl 277 38 with with IN cord-007714-n3omlvfl 277 39 poly(A)-binding poly(a)-binde VBG cord-007714-n3omlvfl 277 40 proteins protein NNS cord-007714-n3omlvfl 277 41 , , , cord-007714-n3omlvfl 277 42 triggers trigger VBZ cord-007714-n3omlvfl 277 43 NMD NMD NNP cord-007714-n3omlvfl 277 44 ( ( -LRB- cord-007714-n3omlvfl 277 45 Bühler Bühler NNP cord-007714-n3omlvfl 277 46 et et NNP cord-007714-n3omlvfl 277 47 al al NNP cord-007714-n3omlvfl 277 48 . . . cord-007714-n3omlvfl 277 49 2006 2006 CD cord-007714-n3omlvfl 277 50 ) ) -RRB- cord-007714-n3omlvfl 277 51 . . . cord-007714-n3omlvfl 278 1 An an DT cord-007714-n3omlvfl 278 2 EJC EJC NNP cord-007714-n3omlvfl 278 3 downstream downstream RB cord-007714-n3omlvfl 278 4 of of IN cord-007714-n3omlvfl 278 5 a a DT cord-007714-n3omlvfl 278 6 premature premature JJ cord-007714-n3omlvfl 278 7 termination termination NN cord-007714-n3omlvfl 278 8 codon codon NN cord-007714-n3omlvfl 278 9 potentially potentially RB cord-007714-n3omlvfl 278 10 acts act VBZ cord-007714-n3omlvfl 278 11 as as IN cord-007714-n3omlvfl 278 12 an an DT cord-007714-n3omlvfl 278 13 enhancer enhancer NN cord-007714-n3omlvfl 278 14 of of IN cord-007714-n3omlvfl 278 15 NMD NMD NNP cord-007714-n3omlvfl 278 16 in in IN cord-007714-n3omlvfl 278 17 this this DT cord-007714-n3omlvfl 278 18 model model NN cord-007714-n3omlvfl 278 19 ( ( -LRB- cord-007714-n3omlvfl 278 20 Bühler Bühler NNP cord-007714-n3omlvfl 278 21 et et NNP cord-007714-n3omlvfl 278 22 al al NNP cord-007714-n3omlvfl 278 23 . . . cord-007714-n3omlvfl 278 24 2006 2006 CD cord-007714-n3omlvfl 278 25 ) ) -RRB- cord-007714-n3omlvfl 278 26 . . . cord-007714-n3omlvfl 279 1 Thus thus RB cord-007714-n3omlvfl 279 2 the the DT cord-007714-n3omlvfl 279 3 underlying underlying JJ cord-007714-n3omlvfl 279 4 mechanism mechanism NN cord-007714-n3omlvfl 279 5 of of IN cord-007714-n3omlvfl 279 6 NMD NMD NNP cord-007714-n3omlvfl 279 7 in in IN cord-007714-n3omlvfl 279 8 mammals mammal NNS cord-007714-n3omlvfl 279 9 may may MD cord-007714-n3omlvfl 279 10 be be VB cord-007714-n3omlvfl 279 11 more more RBR cord-007714-n3omlvfl 279 12 related related JJ cord-007714-n3omlvfl 279 13 to to IN cord-007714-n3omlvfl 279 14 those those DT cord-007714-n3omlvfl 279 15 of of IN cord-007714-n3omlvfl 279 16 yeast yeast NN cord-007714-n3omlvfl 279 17 and and CC cord-007714-n3omlvfl 279 18 Caenorhabiditis Caenorhabiditis NNP cord-007714-n3omlvfl 279 19 elegans elegan NNS cord-007714-n3omlvfl 279 20 , , , cord-007714-n3omlvfl 279 21 which which WDT cord-007714-n3omlvfl 279 22 are be VBP cord-007714-n3omlvfl 279 23 EJC EJC NNP cord-007714-n3omlvfl 279 24 - - HYPH cord-007714-n3omlvfl 279 25 independent independent JJ cord-007714-n3omlvfl 279 26 and and CC cord-007714-n3omlvfl 279 27 rely rely VB cord-007714-n3omlvfl 279 28 on on IN cord-007714-n3omlvfl 279 29 the the DT cord-007714-n3omlvfl 279 30 distance distance NN cord-007714-n3omlvfl 279 31 between between IN cord-007714-n3omlvfl 279 32 the the DT cord-007714-n3omlvfl 279 33 PTC PTC NNP cord-007714-n3omlvfl 279 34 and and CC cord-007714-n3omlvfl 279 35 3′ 3′ CD cord-007714-n3omlvfl 279 36 UTR UTR NNP cord-007714-n3omlvfl 279 37 , , , cord-007714-n3omlvfl 279 38 although although IN cord-007714-n3omlvfl 279 39 , , , cord-007714-n3omlvfl 279 40 in in IN cord-007714-n3omlvfl 279 41 yeast yeast NN cord-007714-n3omlvfl 279 42 , , , cord-007714-n3omlvfl 279 43 this this DT cord-007714-n3omlvfl 279 44 may may MD cord-007714-n3omlvfl 279 45 also also RB cord-007714-n3omlvfl 279 46 involve involve VB cord-007714-n3omlvfl 279 47 specific specific JJ cord-007714-n3omlvfl 279 48 sequences sequence NNS cord-007714-n3omlvfl 279 49 being be VBG cord-007714-n3omlvfl 279 50 recognised recognise VBN cord-007714-n3omlvfl 279 51 by by IN cord-007714-n3omlvfl 279 52 trans trans NNP cord-007714-n3omlvfl 279 53 -acting -acting NN cord-007714-n3omlvfl 279 54 factors factor NNS cord-007714-n3omlvfl 279 55 . . . cord-007714-n3omlvfl 280 1 More More JJR cord-007714-n3omlvfl 280 2 than than IN cord-007714-n3omlvfl 280 3 90 90 CD cord-007714-n3omlvfl 280 4 % % NN cord-007714-n3omlvfl 280 5 of of IN cord-007714-n3omlvfl 280 6 the the DT cord-007714-n3omlvfl 280 7 aberrant aberrant JJ cord-007714-n3omlvfl 280 8 transcripts transcript NNS cord-007714-n3omlvfl 280 9 found find VBN cord-007714-n3omlvfl 280 10 in in IN cord-007714-n3omlvfl 280 11 plant plant NN cord-007714-n3omlvfl 280 12 nucleoli nucleoli NNP cord-007714-n3omlvfl 280 13 are be VBP cord-007714-n3omlvfl 280 14 putative putative JJ cord-007714-n3omlvfl 280 15 NMD NMD NNP cord-007714-n3omlvfl 280 16 substrates substrate NNS cord-007714-n3omlvfl 280 17 based base VBN cord-007714-n3omlvfl 280 18 on on IN cord-007714-n3omlvfl 280 19 NMD NMD NNP cord-007714-n3omlvfl 280 20 determinants determinant NNS cord-007714-n3omlvfl 280 21 in in IN cord-007714-n3omlvfl 280 22 plants plant NNS cord-007714-n3omlvfl 281 1 ( ( -LRB- cord-007714-n3omlvfl 281 2 Kim Kim NNP cord-007714-n3omlvfl 281 3 et et NNP cord-007714-n3omlvfl 281 4 al al NNP cord-007714-n3omlvfl 281 5 . . NNP cord-007714-n3omlvfl 281 6 , , , cord-007714-n3omlvfl 282 1 unpublished unpublished JJ cord-007714-n3omlvfl 282 2 ; ; : cord-007714-n3omlvfl 282 3 Kertész Kertész NNP cord-007714-n3omlvfl 282 4 et et NNP cord-007714-n3omlvfl 282 5 al al NNP cord-007714-n3omlvfl 282 6 . . . cord-007714-n3omlvfl 282 7 2006 2006 CD cord-007714-n3omlvfl 282 8 ) ) -RRB- cord-007714-n3omlvfl 282 9 . . . cord-007714-n3omlvfl 283 1 The the DT cord-007714-n3omlvfl 283 2 majority majority NN cord-007714-n3omlvfl 283 3 of of IN cord-007714-n3omlvfl 283 4 reported report VBN cord-007714-n3omlvfl 283 5 examples example NNS cord-007714-n3omlvfl 283 6 of of IN cord-007714-n3omlvfl 283 7 NMD NMD NNP cord-007714-n3omlvfl 283 8 in in IN cord-007714-n3omlvfl 283 9 plants plant NNS cord-007714-n3omlvfl 283 10 derive derive VBP cord-007714-n3omlvfl 283 11 from from IN cord-007714-n3omlvfl 283 12 intron intron NN cord-007714-n3omlvfl 283 13 - - HYPH cord-007714-n3omlvfl 283 14 containing contain VBG cord-007714-n3omlvfl 283 15 genes gene NNS cord-007714-n3omlvfl 283 16 and and CC cord-007714-n3omlvfl 283 17 , , , cord-007714-n3omlvfl 283 18 for for IN cord-007714-n3omlvfl 283 19 the the DT cord-007714-n3omlvfl 283 20 most most JJS cord-007714-n3omlvfl 283 21 part part NN cord-007714-n3omlvfl 283 22 , , , cord-007714-n3omlvfl 283 23 the the DT cord-007714-n3omlvfl 283 24 positions position NNS cord-007714-n3omlvfl 283 25 of of IN cord-007714-n3omlvfl 283 26 PTCs ptc NNS cord-007714-n3omlvfl 283 27 and and CC cord-007714-n3omlvfl 283 28 exon exon NN cord-007714-n3omlvfl 283 29 junctions junction NNS cord-007714-n3omlvfl 283 30 would would MD cord-007714-n3omlvfl 283 31 be be VB cord-007714-n3omlvfl 283 32 consistent consistent JJ cord-007714-n3omlvfl 283 33 with with IN cord-007714-n3omlvfl 283 34 an an DT cord-007714-n3omlvfl 283 35 EJC EJC NNP cord-007714-n3omlvfl 283 36 - - HYPH cord-007714-n3omlvfl 283 37 dependent dependent JJ cord-007714-n3omlvfl 283 38 or or CC cord-007714-n3omlvfl 283 39 -enhanced -enhanced JJ cord-007714-n3omlvfl 283 40 effect effect NN cord-007714-n3omlvfl 283 41 . . . cord-007714-n3omlvfl 284 1 However however RB cord-007714-n3omlvfl 284 2 , , , cord-007714-n3omlvfl 284 3 it -PRON- PRP cord-007714-n3omlvfl 284 4 is be VBZ cord-007714-n3omlvfl 284 5 also also RB cord-007714-n3omlvfl 284 6 clear clear JJ cord-007714-n3omlvfl 284 7 that that IN cord-007714-n3omlvfl 284 8 EJC EJC NNP cord-007714-n3omlvfl 284 9 - - HYPH cord-007714-n3omlvfl 284 10 independent independent JJ cord-007714-n3omlvfl 284 11 NMD NMD NNP cord-007714-n3omlvfl 284 12 occurs occur VBZ cord-007714-n3omlvfl 284 13 in in IN cord-007714-n3omlvfl 284 14 plants plant NNS cord-007714-n3omlvfl 284 15 with with IN cord-007714-n3omlvfl 284 16 reduced reduce VBN cord-007714-n3omlvfl 284 17 mRNA mrna NN cord-007714-n3omlvfl 284 18 stability stability NN cord-007714-n3omlvfl 284 19 dependent dependent JJ cord-007714-n3omlvfl 284 20 on on IN cord-007714-n3omlvfl 284 21 the the DT cord-007714-n3omlvfl 284 22 position position NN cord-007714-n3omlvfl 284 23 of of IN cord-007714-n3omlvfl 284 24 the the DT cord-007714-n3omlvfl 284 25 PTC PTC NNP cord-007714-n3omlvfl 284 26 in in IN cord-007714-n3omlvfl 284 27 PTC PTC NNP cord-007714-n3omlvfl 284 28 - - HYPH cord-007714-n3omlvfl 284 29 containing contain VBG cord-007714-n3omlvfl 284 30 intronless intronless NN cord-007714-n3omlvfl 284 31 transcripts transcript NNS cord-007714-n3omlvfl 284 32 ( ( -LRB- cord-007714-n3omlvfl 284 33 Van Van NNP cord-007714-n3omlvfl 284 34 Hoof Hoof NNP cord-007714-n3omlvfl 284 35 and and CC cord-007714-n3omlvfl 284 36 Green Green NNP cord-007714-n3omlvfl 284 37 2006 2006 CD cord-007714-n3omlvfl 284 38 ) ) -RRB- cord-007714-n3omlvfl 284 39 . . . cord-007714-n3omlvfl 285 1 Recently recently RB cord-007714-n3omlvfl 285 2 , , , cord-007714-n3omlvfl 285 3 long long JJ cord-007714-n3omlvfl 285 4 3′ 3′ CD cord-007714-n3omlvfl 285 5 UTRs utr NNS cord-007714-n3omlvfl 285 6 and and CC cord-007714-n3omlvfl 285 7 introns intron NNS cord-007714-n3omlvfl 285 8 in in IN cord-007714-n3omlvfl 285 9 the the DT cord-007714-n3omlvfl 285 10 3′ 3′ CD cord-007714-n3omlvfl 285 11 UTR UTR NNP cord-007714-n3omlvfl 285 12 were be VBD cord-007714-n3omlvfl 285 13 shown show VBN cord-007714-n3omlvfl 285 14 to to TO cord-007714-n3omlvfl 285 15 trigger trigger VB cord-007714-n3omlvfl 285 16 NMD NMD NNP cord-007714-n3omlvfl 285 17 in in IN cord-007714-n3omlvfl 285 18 plants plant NNS cord-007714-n3omlvfl 285 19 ( ( -LRB- cord-007714-n3omlvfl 285 20 Kertész Kertész NNP cord-007714-n3omlvfl 285 21 et et NNP cord-007714-n3omlvfl 285 22 al al NNP cord-007714-n3omlvfl 285 23 . . . cord-007714-n3omlvfl 285 24 2006 2006 CD cord-007714-n3omlvfl 285 25 ) ) -RRB- cord-007714-n3omlvfl 285 26 . . . cord-007714-n3omlvfl 286 1 In in IN cord-007714-n3omlvfl 286 2 terms term NNS cord-007714-n3omlvfl 286 3 of of IN cord-007714-n3omlvfl 286 4 the the DT cord-007714-n3omlvfl 286 5 protein protein NN cord-007714-n3omlvfl 286 6 components component NNS cord-007714-n3omlvfl 286 7 of of IN cord-007714-n3omlvfl 286 8 plant plant NN cord-007714-n3omlvfl 286 9 NMD NMD NNP cord-007714-n3omlvfl 286 10 , , , cord-007714-n3omlvfl 286 11 orthologues orthologue NNS cord-007714-n3omlvfl 286 12 of of IN cord-007714-n3omlvfl 286 13 UPF1 UPF1 NNP cord-007714-n3omlvfl 286 14 , , , cord-007714-n3omlvfl 286 15 UPF2 UPF2 NNP cord-007714-n3omlvfl 286 16 and and CC cord-007714-n3omlvfl 286 17 UPF3 UPF3 NNP cord-007714-n3omlvfl 286 18 have have VBP cord-007714-n3omlvfl 286 19 been be VBN cord-007714-n3omlvfl 286 20 identified identify VBN cord-007714-n3omlvfl 286 21 ( ( -LRB- cord-007714-n3omlvfl 286 22 Pendle Pendle NNP cord-007714-n3omlvfl 286 23 et et NNP cord-007714-n3omlvfl 286 24 al al NNP cord-007714-n3omlvfl 286 25 . . NNP cord-007714-n3omlvfl 286 26 2005 2005 CD cord-007714-n3omlvfl 286 27 ; ; : cord-007714-n3omlvfl 286 28 van van NNP cord-007714-n3omlvfl 286 29 Hoof Hoof NNP cord-007714-n3omlvfl 286 30 and and CC cord-007714-n3omlvfl 286 31 Green Green NNP cord-007714-n3omlvfl 286 32 2006 2006 CD cord-007714-n3omlvfl 286 33 ) ) -RRB- cord-007714-n3omlvfl 286 34 . . . cord-007714-n3omlvfl 287 1 Arabidopsis arabidopsis NN cord-007714-n3omlvfl 287 2 gene gene NN cord-007714-n3omlvfl 287 3 orthologues orthologue NNS cord-007714-n3omlvfl 287 4 of of IN cord-007714-n3omlvfl 287 5 UPF1 UPF1 NNP cord-007714-n3omlvfl 287 6 and and CC cord-007714-n3omlvfl 287 7 UPF3 UPF3 NNP cord-007714-n3omlvfl 287 8 have have VBP cord-007714-n3omlvfl 287 9 also also RB cord-007714-n3omlvfl 287 10 been be VBN cord-007714-n3omlvfl 287 11 shown show VBN cord-007714-n3omlvfl 287 12 to to TO cord-007714-n3omlvfl 287 13 function function VB cord-007714-n3omlvfl 287 14 in in IN cord-007714-n3omlvfl 287 15 NMD NMD NNP cord-007714-n3omlvfl 287 16 . . . cord-007714-n3omlvfl 288 1 UPF3 UPF3 NNP cord-007714-n3omlvfl 288 2 suppresses suppress VBZ cord-007714-n3omlvfl 288 3 the the DT cord-007714-n3omlvfl 288 4 levels level NNS cord-007714-n3omlvfl 288 5 of of IN cord-007714-n3omlvfl 288 6 aberrantly aberrantly RB cord-007714-n3omlvfl 288 7 spliced splice VBN cord-007714-n3omlvfl 288 8 , , , cord-007714-n3omlvfl 288 9 PTC PTC NNP cord-007714-n3omlvfl 288 10 - - HYPH cord-007714-n3omlvfl 288 11 containing contain VBG cord-007714-n3omlvfl 288 12 transcripts transcript NNS cord-007714-n3omlvfl 288 13 ( ( -LRB- cord-007714-n3omlvfl 288 14 Hori Hori NNP cord-007714-n3omlvfl 288 15 and and CC cord-007714-n3omlvfl 288 16 Watanabe Watanabe NNP cord-007714-n3omlvfl 288 17 , , , cord-007714-n3omlvfl 288 18 2005 2005 CD cord-007714-n3omlvfl 288 19 ) ) -RRB- cord-007714-n3omlvfl 288 20 , , , cord-007714-n3omlvfl 288 21 and and CC cord-007714-n3omlvfl 288 22 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 288 23 UPF1 UPF1 NNP cord-007714-n3omlvfl 288 24 is be VBZ cord-007714-n3omlvfl 288 25 indispensable indispensable JJ cord-007714-n3omlvfl 289 1 ( ( -LRB- cord-007714-n3omlvfl 289 2 Arciga Arciga NNP cord-007714-n3omlvfl 289 3 - - HYPH cord-007714-n3omlvfl 289 4 Reyes Reyes NNP cord-007714-n3omlvfl 289 5 et et NNP cord-007714-n3omlvfl 289 6 al al NNP cord-007714-n3omlvfl 289 7 . . . cord-007714-n3omlvfl 289 8 2006 2006 CD cord-007714-n3omlvfl 289 9 ) ) -RRB- cord-007714-n3omlvfl 289 10 and and CC cord-007714-n3omlvfl 289 11 causes cause NNS cord-007714-n3omlvfl 289 12 decreased decrease VBD cord-007714-n3omlvfl 289 13 levels level NNS cord-007714-n3omlvfl 289 14 of of IN cord-007714-n3omlvfl 289 15 mRNAs mrnas CD cord-007714-n3omlvfl 289 16 when when WRB cord-007714-n3omlvfl 289 17 tethered tether VBN cord-007714-n3omlvfl 289 18 in in IN cord-007714-n3omlvfl 289 19 different different JJ cord-007714-n3omlvfl 289 20 positions position NNS cord-007714-n3omlvfl 289 21 in in IN cord-007714-n3omlvfl 289 22 mRNAs mrnas CD cord-007714-n3omlvfl 290 1 ( ( -LRB- cord-007714-n3omlvfl 290 2 Kertész Kertész NNP cord-007714-n3omlvfl 290 3 et et NNP cord-007714-n3omlvfl 290 4 al al NNP cord-007714-n3omlvfl 290 5 . . . cord-007714-n3omlvfl 290 6 2006 2006 CD cord-007714-n3omlvfl 290 7 ) ) -RRB- cord-007714-n3omlvfl 290 8 . . . cord-007714-n3omlvfl 291 1 Thus thus RB cord-007714-n3omlvfl 291 2 the the DT cord-007714-n3omlvfl 291 3 rapid rapid JJ cord-007714-n3omlvfl 291 4 degradation degradation NN cord-007714-n3omlvfl 291 5 of of IN cord-007714-n3omlvfl 291 6 PTC PTC NNP cord-007714-n3omlvfl 291 7 - - HYPH cord-007714-n3omlvfl 291 8 containing contain VBG cord-007714-n3omlvfl 291 9 transcripts transcript NNS cord-007714-n3omlvfl 291 10 from from IN cord-007714-n3omlvfl 291 11 both both DT cord-007714-n3omlvfl 291 12 intron intron NN cord-007714-n3omlvfl 291 13 - - HYPH cord-007714-n3omlvfl 291 14 containing contain VBG cord-007714-n3omlvfl 291 15 and and CC cord-007714-n3omlvfl 291 16 intronless intronless NN cord-007714-n3omlvfl 291 17 genes gene NNS cord-007714-n3omlvfl 291 18 , , , cord-007714-n3omlvfl 291 19 and and CC cord-007714-n3omlvfl 291 20 the the DT cord-007714-n3omlvfl 291 21 overall overall JJ cord-007714-n3omlvfl 291 22 conservation conservation NN cord-007714-n3omlvfl 291 23 of of IN cord-007714-n3omlvfl 291 24 EJC EJC NNP cord-007714-n3omlvfl 291 25 and and CC cord-007714-n3omlvfl 291 26 NMD NMD NNP cord-007714-n3omlvfl 291 27 proteins protein NNS cord-007714-n3omlvfl 292 1 ( ( -LRB- cord-007714-n3omlvfl 292 2 Pendle Pendle NNP cord-007714-n3omlvfl 292 3 et et NNP cord-007714-n3omlvfl 292 4 al al NNP cord-007714-n3omlvfl 292 5 . . . cord-007714-n3omlvfl 293 1 2005 2005 CD cord-007714-n3omlvfl 293 2 ; ; : cord-007714-n3omlvfl 293 3 Kertész Kertész NNP cord-007714-n3omlvfl 293 4 et et NNP cord-007714-n3omlvfl 293 5 al al NNP cord-007714-n3omlvfl 293 6 . . . cord-007714-n3omlvfl 294 1 2006 2006 CD cord-007714-n3omlvfl 295 1 ; ; : cord-007714-n3omlvfl 295 2 van van NNP cord-007714-n3omlvfl 295 3 Hoof Hoof NNP cord-007714-n3omlvfl 295 4 and and CC cord-007714-n3omlvfl 295 5 Green Green NNP cord-007714-n3omlvfl 295 6 2006 2006 CD cord-007714-n3omlvfl 295 7 ) ) -RRB- cord-007714-n3omlvfl 295 8 , , , cord-007714-n3omlvfl 295 9 suggests suggest VBZ cord-007714-n3omlvfl 295 10 that that IN cord-007714-n3omlvfl 295 11 both both CC cord-007714-n3omlvfl 295 12 EJC EJC NNP cord-007714-n3omlvfl 295 13 - - HYPH cord-007714-n3omlvfl 295 14 dependent dependent JJ cord-007714-n3omlvfl 295 15 and and CC cord-007714-n3omlvfl 295 16 EJC EJC NNP cord-007714-n3omlvfl 295 17 - - HYPH cord-007714-n3omlvfl 295 18 independent independent JJ cord-007714-n3omlvfl 295 19 mechanisms mechanism NNS cord-007714-n3omlvfl 295 20 are be VBP cord-007714-n3omlvfl 295 21 utilised utilise VBN cord-007714-n3omlvfl 295 22 in in IN cord-007714-n3omlvfl 295 23 plants plant NNS cord-007714-n3omlvfl 295 24 . . . cord-007714-n3omlvfl 296 1 The the DT cord-007714-n3omlvfl 296 2 link link NN cord-007714-n3omlvfl 296 3 between between IN cord-007714-n3omlvfl 296 4 the the DT cord-007714-n3omlvfl 296 5 nucleolus nucleolus NN cord-007714-n3omlvfl 296 6 and and CC cord-007714-n3omlvfl 296 7 NMD NMD NNP cord-007714-n3omlvfl 296 8 in in IN cord-007714-n3omlvfl 296 9 plants plant NNS cord-007714-n3omlvfl 296 10 , , , cord-007714-n3omlvfl 296 11 seen see VBN cord-007714-n3omlvfl 296 12 with with IN cord-007714-n3omlvfl 296 13 the the DT cord-007714-n3omlvfl 296 14 presence presence NN cord-007714-n3omlvfl 296 15 of of IN cord-007714-n3omlvfl 296 16 aberrant aberrant JJ cord-007714-n3omlvfl 296 17 mRNAs mRNAs NNPS cord-007714-n3omlvfl 296 18 in in IN cord-007714-n3omlvfl 296 19 the the DT cord-007714-n3omlvfl 296 20 nucleolus nucleolus NN cord-007714-n3omlvfl 296 21 , , , cord-007714-n3omlvfl 296 22 is be VBZ cord-007714-n3omlvfl 296 23 further far RBR cord-007714-n3omlvfl 296 24 reflected reflect VBN cord-007714-n3omlvfl 296 25 by by IN cord-007714-n3omlvfl 296 26 the the DT cord-007714-n3omlvfl 296 27 localisation localisation NN cord-007714-n3omlvfl 296 28 of of IN cord-007714-n3omlvfl 296 29 UPF2 UPF2 NNP cord-007714-n3omlvfl 296 30 and and CC cord-007714-n3omlvfl 296 31 UPF3 UPF3 NNP cord-007714-n3omlvfl 296 32 to to IN cord-007714-n3omlvfl 296 33 the the DT cord-007714-n3omlvfl 296 34 nucleolus nucleolus NN cord-007714-n3omlvfl 296 35 ( ( -LRB- cord-007714-n3omlvfl 296 36 Kim Kim NNP cord-007714-n3omlvfl 296 37 et et NNP cord-007714-n3omlvfl 296 38 al al NNP cord-007714-n3omlvfl 296 39 . . NNP cord-007714-n3omlvfl 296 40 , , , cord-007714-n3omlvfl 296 41 unpublished unpublished JJ cord-007714-n3omlvfl 296 42 ) ) -RRB- cord-007714-n3omlvfl 296 43 . . . cord-007714-n3omlvfl 297 1 Other other JJ cord-007714-n3omlvfl 297 2 aspects aspect NNS cord-007714-n3omlvfl 297 3 of of IN cord-007714-n3omlvfl 297 4 mRNA mrna NN cord-007714-n3omlvfl 297 5 decay decay NN cord-007714-n3omlvfl 297 6 are be VBP cord-007714-n3omlvfl 297 7 covered cover VBN cord-007714-n3omlvfl 297 8 in in IN cord-007714-n3omlvfl 297 9 the the DT cord-007714-n3omlvfl 297 10 chapter chapter NN cord-007714-n3omlvfl 297 11 by by IN cord-007714-n3omlvfl 297 12 D. D. NNP cord-007714-n3omlvfl 297 13 A. a. NN cord-007714-n3omlvfl 297 14 Belostotsky Belostotsky NNP cord-007714-n3omlvfl 297 15 . . . cord-007714-n3omlvfl 298 1 Over over IN cord-007714-n3omlvfl 298 2 the the DT cord-007714-n3omlvfl 298 3 last last JJ cord-007714-n3omlvfl 298 4 40 40 CD cord-007714-n3omlvfl 298 5 years year NNS cord-007714-n3omlvfl 298 6 and and CC cord-007714-n3omlvfl 298 7 particularly particularly RB cord-007714-n3omlvfl 298 8 in in IN cord-007714-n3omlvfl 298 9 the the DT cord-007714-n3omlvfl 298 10 last last JJ cord-007714-n3omlvfl 298 11 10 10 CD cord-007714-n3omlvfl 298 12 - - SYM cord-007714-n3omlvfl 298 13 15 15 CD cord-007714-n3omlvfl 298 14 years year NNS cord-007714-n3omlvfl 298 15 , , , cord-007714-n3omlvfl 298 16 the the DT cord-007714-n3omlvfl 298 17 nucleolus nucleolus NN cord-007714-n3omlvfl 298 18 has have VBZ cord-007714-n3omlvfl 298 19 grown grow VBN cord-007714-n3omlvfl 298 20 in in IN cord-007714-n3omlvfl 298 21 importance importance NN cord-007714-n3omlvfl 298 22 as as IN cord-007714-n3omlvfl 298 23 a a DT cord-007714-n3omlvfl 298 24 highly highly RB cord-007714-n3omlvfl 298 25 dynamic dynamic JJ cord-007714-n3omlvfl 298 26 centre centre NN cord-007714-n3omlvfl 298 27 of of IN cord-007714-n3omlvfl 298 28 RNA RNA NNP cord-007714-n3omlvfl 298 29 metabolism metabolism NN cord-007714-n3omlvfl 298 30 and and CC cord-007714-n3omlvfl 298 31 RNP RNP NNP cord-007714-n3omlvfl 298 32 assembly assembly NN cord-007714-n3omlvfl 298 33 . . . cord-007714-n3omlvfl 299 1 It -PRON- PRP cord-007714-n3omlvfl 299 2 has have VBZ cord-007714-n3omlvfl 299 3 the the DT cord-007714-n3omlvfl 299 4 major major JJ cord-007714-n3omlvfl 299 5 function function NN cord-007714-n3omlvfl 299 6 in in IN cord-007714-n3omlvfl 299 7 ribosomal ribosomal JJ cord-007714-n3omlvfl 299 8 subunit subunit NN cord-007714-n3omlvfl 299 9 assembly assembly NN cord-007714-n3omlvfl 299 10 needed need VBD cord-007714-n3omlvfl 299 11 to to TO cord-007714-n3omlvfl 299 12 supply supply VB cord-007714-n3omlvfl 299 13 the the DT cord-007714-n3omlvfl 299 14 cell cell NN cord-007714-n3omlvfl 299 15 with with IN cord-007714-n3omlvfl 299 16 ribosomes ribosome NNS cord-007714-n3omlvfl 299 17 for for IN cord-007714-n3omlvfl 299 18 translation translation NN cord-007714-n3omlvfl 299 19 , , , cord-007714-n3omlvfl 299 20 and and CC cord-007714-n3omlvfl 299 21 is be VBZ cord-007714-n3omlvfl 299 22 involved involve VBN cord-007714-n3omlvfl 299 23 in in IN cord-007714-n3omlvfl 299 24 the the DT cord-007714-n3omlvfl 299 25 processing processing NN cord-007714-n3omlvfl 299 26 and and CC cord-007714-n3omlvfl 299 27 assembly assembly NN cord-007714-n3omlvfl 299 28 of of IN cord-007714-n3omlvfl 299 29 many many JJ cord-007714-n3omlvfl 299 30 other other JJ cord-007714-n3omlvfl 299 31 RNAs rna NNS cord-007714-n3omlvfl 299 32 and and CC cord-007714-n3omlvfl 299 33 RNPs rnp NNS cord-007714-n3omlvfl 299 34 . . . cord-007714-n3omlvfl 300 1 Not not RB cord-007714-n3omlvfl 300 2 surprisingly surprisingly RB cord-007714-n3omlvfl 300 3 , , , cord-007714-n3omlvfl 300 4 therefore therefore RB cord-007714-n3omlvfl 300 5 , , , cord-007714-n3omlvfl 300 6 the the DT cord-007714-n3omlvfl 300 7 nucleolus nucleolus NN cord-007714-n3omlvfl 300 8 is be VBZ cord-007714-n3omlvfl 300 9 involved involve VBN cord-007714-n3omlvfl 300 10 in in IN cord-007714-n3omlvfl 300 11 the the DT cord-007714-n3omlvfl 300 12 regulation regulation NN cord-007714-n3omlvfl 300 13 of of IN cord-007714-n3omlvfl 300 14 key key JJ cord-007714-n3omlvfl 300 15 cellular cellular JJ cord-007714-n3omlvfl 300 16 processes process NNS cord-007714-n3omlvfl 300 17 and and CC cord-007714-n3omlvfl 300 18 responds respond VBZ cord-007714-n3omlvfl 300 19 to to IN cord-007714-n3omlvfl 300 20 growth growth NN cord-007714-n3omlvfl 300 21 conditions condition NNS cord-007714-n3omlvfl 300 22 and and CC cord-007714-n3omlvfl 300 23 external external JJ cord-007714-n3omlvfl 300 24 stresses stress NNS cord-007714-n3omlvfl 300 25 . . . cord-007714-n3omlvfl 301 1 The the DT cord-007714-n3omlvfl 301 2 recent recent JJ cord-007714-n3omlvfl 301 3 links link NNS cord-007714-n3omlvfl 301 4 to to IN cord-007714-n3omlvfl 301 5 transcriptional transcriptional JJ cord-007714-n3omlvfl 301 6 silencing silencing NN cord-007714-n3omlvfl 301 7 , , , cord-007714-n3omlvfl 301 8 mRNA mrna NN cord-007714-n3omlvfl 301 9 export export NN cord-007714-n3omlvfl 301 10 and and CC cord-007714-n3omlvfl 301 11 NMD NMD NNP cord-007714-n3omlvfl 301 12 in in IN cord-007714-n3omlvfl 301 13 plants plant NNS cord-007714-n3omlvfl 301 14 not not RB cord-007714-n3omlvfl 301 15 only only RB cord-007714-n3omlvfl 301 16 add add VB cord-007714-n3omlvfl 301 17 to to IN cord-007714-n3omlvfl 301 18 the the DT cord-007714-n3omlvfl 301 19 multiple multiple JJ cord-007714-n3omlvfl 301 20 functions function NNS cord-007714-n3omlvfl 301 21 of of IN cord-007714-n3omlvfl 301 22 the the DT cord-007714-n3omlvfl 301 23 nucleolus nucleolus NN cord-007714-n3omlvfl 301 24 but but CC cord-007714-n3omlvfl 301 25 also also RB cord-007714-n3omlvfl 301 26 enhance enhance VB cord-007714-n3omlvfl 301 27 the the DT cord-007714-n3omlvfl 301 28 concept concept NN cord-007714-n3omlvfl 301 29 of of IN cord-007714-n3omlvfl 301 30 a a DT cord-007714-n3omlvfl 301 31 role role NN cord-007714-n3omlvfl 301 32 for for IN cord-007714-n3omlvfl 301 33 the the DT cord-007714-n3omlvfl 301 34 nucleolus nucleolus NN cord-007714-n3omlvfl 301 35 in in IN cord-007714-n3omlvfl 301 36 co co JJ cord-007714-n3omlvfl 301 37 - - JJ cord-007714-n3omlvfl 301 38 ordinating ordinating JJ cord-007714-n3omlvfl 301 39 different different JJ cord-007714-n3omlvfl 301 40 RNA RNA NNP cord-007714-n3omlvfl 301 41 metabolism metabolism NN cord-007714-n3omlvfl 301 42 pathways pathway NNS cord-007714-n3omlvfl 301 43 . . . cord-007714-n3omlvfl 302 1 Cotranscriptional Cotranscriptional NNP cord-007714-n3omlvfl 302 2 mRNP mrnp NN cord-007714-n3omlvfl 302 3 assembly assembly NN cord-007714-n3omlvfl 302 4 : : : cord-007714-n3omlvfl 302 5 from from IN cord-007714-n3omlvfl 302 6 the the DT cord-007714-n3omlvfl 302 7 DNA dna NN cord-007714-n3omlvfl 302 8 to to IN cord-007714-n3omlvfl 302 9 the the DT cord-007714-n3omlvfl 302 10 nuclear nuclear JJ cord-007714-n3omlvfl 302 11 pore pore NN cord-007714-n3omlvfl 302 12 Molecular molecular JJ cord-007714-n3omlvfl 302 13 interaction interaction NN cord-007714-n3omlvfl 302 14 between between IN cord-007714-n3omlvfl 302 15 COP1 COP1 NNP cord-007714-n3omlvfl 302 16 and and CC cord-007714-n3omlvfl 302 17 HY5 HY5 NNP cord-007714-n3omlvfl 302 18 defines define VBZ cord-007714-n3omlvfl 302 19 a a DT cord-007714-n3omlvfl 302 20 regulatory regulatory JJ cord-007714-n3omlvfl 302 21 switch switch NN cord-007714-n3omlvfl 302 22 for for IN cord-007714-n3omlvfl 302 23 light light JJ cord-007714-n3omlvfl 302 24 control control NN cord-007714-n3omlvfl 302 25 of of IN cord-007714-n3omlvfl 302 26 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 302 27 development development NN cord-007714-n3omlvfl 302 28 Directed direct VBD cord-007714-n3omlvfl 302 29 proteomic proteomic JJ cord-007714-n3omlvfl 302 30 analysis analysis NN cord-007714-n3omlvfl 302 31 of of IN cord-007714-n3omlvfl 302 32 the the DT cord-007714-n3omlvfl 302 33 human human JJ cord-007714-n3omlvfl 302 34 nucleolus nucleolus NN cord-007714-n3omlvfl 302 35 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 302 36 proteome proteome NN cord-007714-n3omlvfl 302 37 dynamics dynamic NNS cord-007714-n3omlvfl 302 38 Structure Structure NNP cord-007714-n3omlvfl 302 39 of of IN cord-007714-n3omlvfl 302 40 the the DT cord-007714-n3omlvfl 302 41 exon exon NN cord-007714-n3omlvfl 302 42 junction junction NN cord-007714-n3omlvfl 302 43 core core NN cord-007714-n3omlvfl 302 44 complex complex NN cord-007714-n3omlvfl 302 45 with with IN cord-007714-n3omlvfl 302 46 a a DT cord-007714-n3omlvfl 302 47 trapped trap VBN cord-007714-n3omlvfl 302 48 DEAD DEAD NNP cord-007714-n3omlvfl 302 49 - - HYPH cord-007714-n3omlvfl 302 50 box box NN cord-007714-n3omlvfl 302 51 ATPase atpase NN cord-007714-n3omlvfl 302 52 bound bind VBN cord-007714-n3omlvfl 302 53 to to IN cord-007714-n3omlvfl 302 54 RNA RNA NNP cord-007714-n3omlvfl 302 55 UPF1 UPF1 NNP cord-007714-n3omlvfl 302 56 is be VBZ cord-007714-n3omlvfl 302 57 required require VBN cord-007714-n3omlvfl 302 58 for for IN cord-007714-n3omlvfl 302 59 nonsense nonsense NN cord-007714-n3omlvfl 302 60 - - HYPH cord-007714-n3omlvfl 302 61 mediated mediate VBN cord-007714-n3omlvfl 302 62 mRNA mrna NN cord-007714-n3omlvfl 302 63 decay decay NN cord-007714-n3omlvfl 302 64 ( ( -LRB- cord-007714-n3omlvfl 302 65 NMD NMD NNP cord-007714-n3omlvfl 302 66 ) ) -RRB- cord-007714-n3omlvfl 302 67 and and CC cord-007714-n3omlvfl 302 68 RNAi RNAi NNS cord-007714-n3omlvfl 302 69 in in IN cord-007714-n3omlvfl 302 70 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 303 1 The the DT cord-007714-n3omlvfl 303 2 organisation organisation NN cord-007714-n3omlvfl 303 3 of of IN cord-007714-n3omlvfl 303 4 cytoplasmic cytoplasmic JJ cord-007714-n3omlvfl 303 5 ribosomal ribosomal JJ cord-007714-n3omlvfl 303 6 protein protein NN cord-007714-n3omlvfl 303 7 genes gene NNS cord-007714-n3omlvfl 303 8 in in IN cord-007714-n3omlvfl 303 9 the the DT cord-007714-n3omlvfl 303 10 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 303 11 genome genome NN cord-007714-n3omlvfl 303 12 Identification identification NN cord-007714-n3omlvfl 303 13 of of IN cord-007714-n3omlvfl 303 14 66 66 CD cord-007714-n3omlvfl 303 15 box box NN cord-007714-n3omlvfl 303 16 C C NNP cord-007714-n3omlvfl 303 17 / / SYM cord-007714-n3omlvfl 303 18 D D NNP cord-007714-n3omlvfl 303 19 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 303 20 in in IN cord-007714-n3omlvfl 303 21 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 303 22 thaliana thaliana NN cord-007714-n3omlvfl 303 23 : : : cord-007714-n3omlvfl 303 24 Extensive extensive JJ cord-007714-n3omlvfl 303 25 gene gene NN cord-007714-n3omlvfl 303 26 duplications duplication NNS cord-007714-n3omlvfl 303 27 generated generate VBD cord-007714-n3omlvfl 303 28 multiple multiple JJ cord-007714-n3omlvfl 303 29 isoforms isoform NNS cord-007714-n3omlvfl 303 30 predicting predict VBG cord-007714-n3omlvfl 303 31 new new JJ cord-007714-n3omlvfl 303 32 ribosomal ribosomal JJ cord-007714-n3omlvfl 303 33 RNA RNA NNP cord-007714-n3omlvfl 303 34 2′-O 2′-o CD cord-007714-n3omlvfl 303 35 -methylation -methylation CD cord-007714-n3omlvfl 303 36 sites site NNS cord-007714-n3omlvfl 303 37 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 303 38 localization localization NN cord-007714-n3omlvfl 303 39 of of IN cord-007714-n3omlvfl 303 40 early early JJ cord-007714-n3omlvfl 303 41 tRNA trna NN cord-007714-n3omlvfl 303 42 processing processing NN cord-007714-n3omlvfl 303 43 genes gene NNS cord-007714-n3omlvfl 304 1 The the DT cord-007714-n3omlvfl 304 2 organization organization NN cord-007714-n3omlvfl 304 3 of of IN cord-007714-n3omlvfl 304 4 ribosomal ribosomal NNP cord-007714-n3omlvfl 304 5 RNA RNA NNP cord-007714-n3omlvfl 304 6 processing processing NN cord-007714-n3omlvfl 304 7 correlates correlate VBZ cord-007714-n3omlvfl 304 8 with with IN cord-007714-n3omlvfl 304 9 the the DT cord-007714-n3omlvfl 304 10 distribution distribution NN cord-007714-n3omlvfl 304 11 of of IN cord-007714-n3omlvfl 304 12 nucleolar nucleolar JJ cord-007714-n3omlvfl 304 13 snRNAs snRNAs NNP cord-007714-n3omlvfl 305 1 The the DT cord-007714-n3omlvfl 305 2 organization organization NN cord-007714-n3omlvfl 305 3 of of IN cord-007714-n3omlvfl 305 4 spliceosomal spliceosomal NNP cord-007714-n3omlvfl 305 5 components component NNS cord-007714-n3omlvfl 305 6 in in IN cord-007714-n3omlvfl 305 7 the the DT cord-007714-n3omlvfl 305 8 nuclei nucleus NNS cord-007714-n3omlvfl 305 9 of of IN cord-007714-n3omlvfl 305 10 higher high JJR cord-007714-n3omlvfl 305 11 plants plant NNS cord-007714-n3omlvfl 305 12 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 305 13 localisation localisation NN cord-007714-n3omlvfl 305 14 of of IN cord-007714-n3omlvfl 305 15 myc myc NNP cord-007714-n3omlvfl 305 16 transcripts transcripts NNPS cord-007714-n3omlvfl 306 1 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 306 2 trafficking trafficking NN cord-007714-n3omlvfl 306 3 is be VBZ cord-007714-n3omlvfl 306 4 essential essential JJ cord-007714-n3omlvfl 306 5 for for IN cord-007714-n3omlvfl 306 6 nuclear nuclear JJ cord-007714-n3omlvfl 306 7 export export NN cord-007714-n3omlvfl 306 8 of of IN cord-007714-n3omlvfl 306 9 intronless intronless NNP cord-007714-n3omlvfl 306 10 herpesvirus herpesvirus NNP cord-007714-n3omlvfl 306 11 mRNA mrna NN cord-007714-n3omlvfl 307 1 The the DT cord-007714-n3omlvfl 307 2 multifunctional multifunctional JJ cord-007714-n3omlvfl 307 3 nucleolus nucleolus NN cord-007714-n3omlvfl 307 4 Coiled coil VBN cord-007714-n3omlvfl 307 5 body body NN cord-007714-n3omlvfl 307 6 numbers number NNS cord-007714-n3omlvfl 307 7 in in IN cord-007714-n3omlvfl 307 8 the the DT cord-007714-n3omlvfl 307 9 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 307 10 root root NN cord-007714-n3omlvfl 307 11 epidermis epidermi NNS cord-007714-n3omlvfl 307 12 are be VBP cord-007714-n3omlvfl 307 13 regulated regulate VBN cord-007714-n3omlvfl 307 14 by by IN cord-007714-n3omlvfl 307 15 cell cell NN cord-007714-n3omlvfl 307 16 type type NN cord-007714-n3omlvfl 307 17 , , , cord-007714-n3omlvfl 307 18 developmental developmental JJ cord-007714-n3omlvfl 307 19 stage stage NN cord-007714-n3omlvfl 307 20 and and CC cord-007714-n3omlvfl 307 21 cell cell NN cord-007714-n3omlvfl 307 22 cycle cycle NN cord-007714-n3omlvfl 307 23 parameters parameter NNS cord-007714-n3omlvfl 308 1 The the DT cord-007714-n3omlvfl 308 2 movement movement NN cord-007714-n3omlvfl 308 3 of of IN cord-007714-n3omlvfl 308 4 coiled coiled JJ cord-007714-n3omlvfl 308 5 bodies body NNS cord-007714-n3omlvfl 308 6 visualized visualize VBN cord-007714-n3omlvfl 308 7 in in IN cord-007714-n3omlvfl 308 8 living live VBG cord-007714-n3omlvfl 308 9 plant plant NN cord-007714-n3omlvfl 308 10 cells cell NNS cord-007714-n3omlvfl 308 11 by by IN cord-007714-n3omlvfl 308 12 the the DT cord-007714-n3omlvfl 308 13 green green JJ cord-007714-n3omlvfl 308 14 fluorescent fluorescent NN cord-007714-n3omlvfl 308 15 protein protein NN cord-007714-n3omlvfl 308 16 Pre Pre NNP cord-007714-n3omlvfl 308 17 - - NNP cord-007714-n3omlvfl 308 18 mRNA mRNA NNP cord-007714-n3omlvfl 308 19 processing processing NN cord-007714-n3omlvfl 308 20 factors factor NNS cord-007714-n3omlvfl 308 21 are be VBP cord-007714-n3omlvfl 308 22 required require VBN cord-007714-n3omlvfl 308 23 for for IN cord-007714-n3omlvfl 308 24 nuclear nuclear JJ cord-007714-n3omlvfl 308 25 export export NN cord-007714-n3omlvfl 308 26 Multiple Multiple NNP cord-007714-n3omlvfl 308 27 snoRNA snoRNA NNP cord-007714-n3omlvfl 308 28 gene gene NN cord-007714-n3omlvfl 308 29 clusters cluster NNS cord-007714-n3omlvfl 308 30 from from IN cord-007714-n3omlvfl 308 31 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 308 32 Plant Plant NNP cord-007714-n3omlvfl 308 33 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 308 34 : : : cord-007714-n3omlvfl 308 35 functional functional JJ cord-007714-n3omlvfl 308 36 evolution evolution NN cord-007714-n3omlvfl 308 37 and and CC cord-007714-n3omlvfl 308 38 new new JJ cord-007714-n3omlvfl 308 39 modes mode NNS cord-007714-n3omlvfl 308 40 of of IN cord-007714-n3omlvfl 308 41 gene gene NN cord-007714-n3omlvfl 308 42 expression expression NN cord-007714-n3omlvfl 308 43 Small small JJ cord-007714-n3omlvfl 308 44 nucleolar nucleolar JJ cord-007714-n3omlvfl 308 45 RNAs rna NNS cord-007714-n3omlvfl 308 46 and and CC cord-007714-n3omlvfl 308 47 pre pre JJ cord-007714-n3omlvfl 308 48 - - JJ cord-007714-n3omlvfl 308 49 rRNA rrna JJ cord-007714-n3omlvfl 308 50 processing processing NN cord-007714-n3omlvfl 308 51 in in IN cord-007714-n3omlvfl 308 52 plants plant NNS cord-007714-n3omlvfl 308 53 EJC EJC NNP cord-007714-n3omlvfl 308 54 - - HYPH cord-007714-n3omlvfl 308 55 independent independent JJ cord-007714-n3omlvfl 308 56 degradation degradation NN cord-007714-n3omlvfl 308 57 of of IN cord-007714-n3omlvfl 308 58 nonsense nonsense NN cord-007714-n3omlvfl 308 59 immunoglobulin-µ immunoglobulin-µ NNP cord-007714-n3omlvfl 308 60 mRNA mrna NN cord-007714-n3omlvfl 308 61 depends depend VBZ cord-007714-n3omlvfl 308 62 on on IN cord-007714-n3omlvfl 308 63 3′ 3′ CD cord-007714-n3omlvfl 308 64 UTR UTR NNP cord-007714-n3omlvfl 308 65 length length NN cord-007714-n3omlvfl 308 66 Translocation Translocation NNP cord-007714-n3omlvfl 308 67 of of IN cord-007714-n3omlvfl 308 68 Tomato Tomato NNP cord-007714-n3omlvfl 308 69 Bushy Bushy NNP cord-007714-n3omlvfl 308 70 Stunt Stunt NNP cord-007714-n3omlvfl 308 71 Virus Virus NNP cord-007714-n3omlvfl 308 72 p19 p19 NN cord-007714-n3omlvfl 308 73 protein protein NN cord-007714-n3omlvfl 308 74 into into IN cord-007714-n3omlvfl 308 75 the the DT cord-007714-n3omlvfl 308 76 nucleus nucleus NN cord-007714-n3omlvfl 308 77 by by IN cord-007714-n3omlvfl 308 78 ALY ALY NNP cord-007714-n3omlvfl 308 79 proteins protein NNS cord-007714-n3omlvfl 308 80 compromises compromise VBZ cord-007714-n3omlvfl 308 81 its -PRON- PRP$ cord-007714-n3omlvfl 308 82 silencing silence VBG cord-007714-n3omlvfl 308 83 suppressor suppressor NN cord-007714-n3omlvfl 308 84 activity activity NN cord-007714-n3omlvfl 308 85 Depletion depletion NN cord-007714-n3omlvfl 308 86 of of IN cord-007714-n3omlvfl 308 87 the the DT cord-007714-n3omlvfl 308 88 yeast yeast NN cord-007714-n3omlvfl 308 89 nuclear nuclear JJ cord-007714-n3omlvfl 308 90 exosome exosome NN cord-007714-n3omlvfl 308 91 subunit subunit NN cord-007714-n3omlvfl 308 92 Rrp6 Rrp6 NNP cord-007714-n3omlvfl 308 93 results result NNS cord-007714-n3omlvfl 308 94 in in IN cord-007714-n3omlvfl 308 95 accumulation accumulation NN cord-007714-n3omlvfl 308 96 of of IN cord-007714-n3omlvfl 308 97 polyadenylated polyadenylated JJ cord-007714-n3omlvfl 308 98 RNAs rna NNS cord-007714-n3omlvfl 308 99 in in IN cord-007714-n3omlvfl 308 100 a a DT cord-007714-n3omlvfl 308 101 discrete discrete JJ cord-007714-n3omlvfl 308 102 domain domain NN cord-007714-n3omlvfl 308 103 within within IN cord-007714-n3omlvfl 308 104 the the DT cord-007714-n3omlvfl 308 105 nucleolus nucleolus NN cord-007714-n3omlvfl 308 106 Beginning begin VBG cord-007714-n3omlvfl 308 107 to to TO cord-007714-n3omlvfl 308 108 understand understand VB cord-007714-n3omlvfl 308 109 the the DT cord-007714-n3omlvfl 308 110 end end NN cord-007714-n3omlvfl 308 111 of of IN cord-007714-n3omlvfl 308 112 the the DT cord-007714-n3omlvfl 308 113 chromosome chromosome NN cord-007714-n3omlvfl 308 114 Characterization characterization NN cord-007714-n3omlvfl 308 115 of of IN cord-007714-n3omlvfl 308 116 the the DT cord-007714-n3omlvfl 308 117 requirements requirement NNS cord-007714-n3omlvfl 308 118 for for IN cord-007714-n3omlvfl 308 119 localization localization NN cord-007714-n3omlvfl 308 120 of of IN cord-007714-n3omlvfl 308 121 phytochrome phytochrome NN cord-007714-n3omlvfl 308 122 B b NN cord-007714-n3omlvfl 308 123 to to IN cord-007714-n3omlvfl 308 124 nuclear nuclear JJ cord-007714-n3omlvfl 308 125 bodies body NNS cord-007714-n3omlvfl 308 126 Dynamics dynamic NNS cord-007714-n3omlvfl 308 127 of of IN cord-007714-n3omlvfl 308 128 nucleolar nucleolar JJ cord-007714-n3omlvfl 308 129 components component NNS cord-007714-n3omlvfl 308 130 Cajal Cajal NNP cord-007714-n3omlvfl 308 131 bodies body NNS cord-007714-n3omlvfl 308 132 : : : cord-007714-n3omlvfl 308 133 a a DT cord-007714-n3omlvfl 308 134 long long JJ cord-007714-n3omlvfl 308 135 history history NN cord-007714-n3omlvfl 308 136 of of IN cord-007714-n3omlvfl 308 137 discovery discovery NN cord-007714-n3omlvfl 309 1 A a DT cord-007714-n3omlvfl 309 2 distant distant JJ cord-007714-n3omlvfl 309 3 coilin coilin NN cord-007714-n3omlvfl 309 4 homologue homologue NN cord-007714-n3omlvfl 309 5 is be VBZ cord-007714-n3omlvfl 309 6 required require VBN cord-007714-n3omlvfl 309 7 for for IN cord-007714-n3omlvfl 309 8 the the DT cord-007714-n3omlvfl 309 9 formation formation NN cord-007714-n3omlvfl 309 10 of of IN cord-007714-n3omlvfl 309 11 Cajal Cajal NNP cord-007714-n3omlvfl 309 12 bodies body NNS cord-007714-n3omlvfl 309 13 in in IN cord-007714-n3omlvfl 309 14 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 309 15 Nonsense nonsense NN cord-007714-n3omlvfl 309 16 - - HYPH cord-007714-n3omlvfl 309 17 mediated mediate VBN cord-007714-n3omlvfl 309 18 decay decay NN cord-007714-n3omlvfl 309 19 : : : cord-007714-n3omlvfl 309 20 molecular molecular JJ cord-007714-n3omlvfl 309 21 insights insight NNS cord-007714-n3omlvfl 309 22 and and CC cord-007714-n3omlvfl 309 23 mechanistic mechanistic JJ cord-007714-n3omlvfl 309 24 variations variation NNS cord-007714-n3omlvfl 309 25 across across IN cord-007714-n3omlvfl 309 26 species specie NNS cord-007714-n3omlvfl 309 27 Looking look VBG cord-007714-n3omlvfl 309 28 at at IN cord-007714-n3omlvfl 309 29 mRNA mrna NN cord-007714-n3omlvfl 309 30 decay decay VB cord-007714-n3omlvfl 309 31 pathways pathway NNS cord-007714-n3omlvfl 309 32 through through IN cord-007714-n3omlvfl 309 33 the the DT cord-007714-n3omlvfl 309 34 window window NN cord-007714-n3omlvfl 309 35 of of IN cord-007714-n3omlvfl 309 36 molecular molecular JJ cord-007714-n3omlvfl 309 37 evolution evolution NN cord-007714-n3omlvfl 310 1 In in IN cord-007714-n3omlvfl 310 2 vivo vivo NN cord-007714-n3omlvfl 310 3 recruitment recruitment NN cord-007714-n3omlvfl 310 4 of of IN cord-007714-n3omlvfl 310 5 exon exon NNP cord-007714-n3omlvfl 310 6 junction junction NN cord-007714-n3omlvfl 310 7 complex complex NN cord-007714-n3omlvfl 310 8 proteins protein NNS cord-007714-n3omlvfl 310 9 to to IN cord-007714-n3omlvfl 310 10 transcription transcription NN cord-007714-n3omlvfl 310 11 sites site NNS cord-007714-n3omlvfl 310 12 in in IN cord-007714-n3omlvfl 310 13 mammalian mammalian JJ cord-007714-n3omlvfl 310 14 cell cell NN cord-007714-n3omlvfl 310 15 nuclei nucleus NNS cord-007714-n3omlvfl 310 16 Cajal Cajal NNP cord-007714-n3omlvfl 310 17 body body NN cord-007714-n3omlvfl 310 18 - - HYPH cord-007714-n3omlvfl 310 19 specific specific JJ cord-007714-n3omlvfl 310 20 small small JJ cord-007714-n3omlvfl 310 21 nuclear nuclear JJ cord-007714-n3omlvfl 310 22 RNAs rna NNS cord-007714-n3omlvfl 310 23 : : : cord-007714-n3omlvfl 310 24 a a DT cord-007714-n3omlvfl 310 25 novel novel JJ cord-007714-n3omlvfl 310 26 class class NN cord-007714-n3omlvfl 310 27 of of IN cord-007714-n3omlvfl 311 1 2′-O 2′-o LS cord-007714-n3omlvfl 311 2 -methylation -methylation CD cord-007714-n3omlvfl 311 3 and and CC cord-007714-n3omlvfl 311 4 pseudouridylation pseudouridylation NN cord-007714-n3omlvfl 311 5 guide guide NN cord-007714-n3omlvfl 311 6 RNAs rna NNS cord-007714-n3omlvfl 311 7 rRNA rrna NN cord-007714-n3omlvfl 311 8 modifications modification NNS cord-007714-n3omlvfl 311 9 and and CC cord-007714-n3omlvfl 311 10 ribosome ribosome NN cord-007714-n3omlvfl 311 11 function function NN cord-007714-n3omlvfl 311 12 Changes change NNS cord-007714-n3omlvfl 311 13 in in IN cord-007714-n3omlvfl 311 14 nucleolar nucleolar JJ cord-007714-n3omlvfl 311 15 morphology morphology NN cord-007714-n3omlvfl 311 16 and and CC cord-007714-n3omlvfl 311 17 proteins protein NNS cord-007714-n3omlvfl 311 18 during during IN cord-007714-n3omlvfl 311 19 infection infection NN cord-007714-n3omlvfl 311 20 with with IN cord-007714-n3omlvfl 311 21 the the DT cord-007714-n3omlvfl 311 22 corona corona NN cord-007714-n3omlvfl 311 23 virus virus NN cord-007714-n3omlvfl 311 24 infectious infectious JJ cord-007714-n3omlvfl 311 25 bronchitis bronchitis NN cord-007714-n3omlvfl 311 26 virus virus NN cord-007714-n3omlvfl 312 1 A a DT cord-007714-n3omlvfl 312 2 large large JJ cord-007714-n3omlvfl 312 3 nucleolar nucleolar JJ cord-007714-n3omlvfl 312 4 U3 u3 NN cord-007714-n3omlvfl 312 5 ribonucleoprotein ribonucleoprotein NN cord-007714-n3omlvfl 312 6 required require VBN cord-007714-n3omlvfl 312 7 for for IN cord-007714-n3omlvfl 312 8 18S 18s JJ cord-007714-n3omlvfl 312 9 ribosomal ribosomal JJ cord-007714-n3omlvfl 312 10 RNA RNA NNP cord-007714-n3omlvfl 312 11 biogenesis biogenesis NN cord-007714-n3omlvfl 313 1 The the DT cord-007714-n3omlvfl 313 2 nucleolar nucleolar JJ cord-007714-n3omlvfl 313 3 localisation localisation NN cord-007714-n3omlvfl 313 4 domain domain NN cord-007714-n3omlvfl 313 5 of of IN cord-007714-n3omlvfl 313 6 of of IN cord-007714-n3omlvfl 313 7 the the DT cord-007714-n3omlvfl 313 8 catalytic catalytic JJ cord-007714-n3omlvfl 313 9 subunit subunit NN cord-007714-n3omlvfl 313 10 of of IN cord-007714-n3omlvfl 313 11 human human JJ cord-007714-n3omlvfl 313 12 telomerase telomerase NN cord-007714-n3omlvfl 313 13 Making make VBG cord-007714-n3omlvfl 313 14 ribosomes ribosome NNS cord-007714-n3omlvfl 313 15 Coiled coiled JJ cord-007714-n3omlvfl 313 16 bodies body NNS cord-007714-n3omlvfl 313 17 contain contain VBP cord-007714-n3omlvfl 313 18 U7 U7 NNP cord-007714-n3omlvfl 313 19 small small JJ cord-007714-n3omlvfl 313 20 nuclear nuclear NN cord-007714-n3omlvfl 313 21 RNA RNA NNP cord-007714-n3omlvfl 313 22 and and CC cord-007714-n3omlvfl 313 23 associate associate VB cord-007714-n3omlvfl 313 24 with with IN cord-007714-n3omlvfl 313 25 specific specific JJ cord-007714-n3omlvfl 313 26 DNA dna NN cord-007714-n3omlvfl 313 27 sequences sequence NNS cord-007714-n3omlvfl 313 28 in in IN cord-007714-n3omlvfl 313 29 interphase interphase NN cord-007714-n3omlvfl 313 30 human human JJ cord-007714-n3omlvfl 313 31 cells cell NNS cord-007714-n3omlvfl 314 1 RNA RNA NNP cord-007714-n3omlvfl 314 2 polymerase polymerase NNP cord-007714-n3omlvfl 315 1 I -PRON- PRP cord-007714-n3omlvfl 315 2 transcription transcription VBP cord-007714-n3omlvfl 315 3 and and CC cord-007714-n3omlvfl 315 4 pre pre JJ cord-007714-n3omlvfl 315 5 - - JJ cord-007714-n3omlvfl 315 6 rRNA rrna JJ cord-007714-n3omlvfl 315 7 processing processing NN cord-007714-n3omlvfl 315 8 are be VBP cord-007714-n3omlvfl 315 9 linked link VBN cord-007714-n3omlvfl 315 10 by by IN cord-007714-n3omlvfl 315 11 specific specific JJ cord-007714-n3omlvfl 315 12 SSU SSU NNP cord-007714-n3omlvfl 315 13 processosome processosome NN cord-007714-n3omlvfl 315 14 components component NNS cord-007714-n3omlvfl 315 15 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 315 16 factors factor NNS cord-007714-n3omlvfl 315 17 direct direct VBP cord-007714-n3omlvfl 315 18 the the DT cord-007714-n3omlvfl 315 19 2′-O 2′-o CD cord-007714-n3omlvfl 315 20 -ribose -ribose SYM cord-007714-n3omlvfl 315 21 methylation methylation NN cord-007714-n3omlvfl 315 22 and and CC cord-007714-n3omlvfl 315 23 pseudouridylation pseudouridylation NN cord-007714-n3omlvfl 315 24 of of IN cord-007714-n3omlvfl 315 25 U6 U6 NNP cord-007714-n3omlvfl 315 26 spliceosomal spliceosomal NN cord-007714-n3omlvfl 315 27 RNA RNA NNP cord-007714-n3omlvfl 315 28 REF1 REF1 NNP cord-007714-n3omlvfl 315 29 / / SYM cord-007714-n3omlvfl 315 30 Aly Aly NNP cord-007714-n3omlvfl 315 31 and and CC cord-007714-n3omlvfl 315 32 the the DT cord-007714-n3omlvfl 315 33 additional additional JJ cord-007714-n3omlvfl 315 34 exon exon NN cord-007714-n3omlvfl 315 35 junction junction NN cord-007714-n3omlvfl 315 36 complex complex JJ cord-007714-n3omlvfl 315 37 proteins protein NNS cord-007714-n3omlvfl 315 38 are be VBP cord-007714-n3omlvfl 315 39 dispensible dispensible JJ cord-007714-n3omlvfl 315 40 for for IN cord-007714-n3omlvfl 315 41 nuclear nuclear JJ cord-007714-n3omlvfl 315 42 mRNA mRNA NNP cord-007714-n3omlvfl 315 43 export export NN cord-007714-n3omlvfl 316 1 All all DT cord-007714-n3omlvfl 316 2 small small JJ cord-007714-n3omlvfl 316 3 nuclear nuclear JJ cord-007714-n3omlvfl 316 4 RNAs rna NNS cord-007714-n3omlvfl 316 5 ( ( -LRB- cord-007714-n3omlvfl 316 6 snRNAs snRNAs NNP cord-007714-n3omlvfl 316 7 ) ) -RRB- cord-007714-n3omlvfl 316 8 of of IN cord-007714-n3omlvfl 316 9 the the DT cord-007714-n3omlvfl 316 10 [ [ -LRB- cord-007714-n3omlvfl 316 11 U4 U4 NNP cord-007714-n3omlvfl 316 12 / / SYM cord-007714-n3omlvfl 316 13 U6.U5 U6.U5 NNP cord-007714-n3omlvfl 316 14 ] ] -RRB- cord-007714-n3omlvfl 316 15 tri tri JJ cord-007714-n3omlvfl 316 16 - - JJ cord-007714-n3omlvfl 316 17 snRNP snrnp JJ cord-007714-n3omlvfl 316 18 localize localize NN cord-007714-n3omlvfl 316 19 to to IN cord-007714-n3omlvfl 316 20 nucleoli nucleoli NNP cord-007714-n3omlvfl 316 21 ; ; : cord-007714-n3omlvfl 316 22 Identification identification NN cord-007714-n3omlvfl 316 23 of of IN cord-007714-n3omlvfl 316 24 the the DT cord-007714-n3omlvfl 316 25 nucleolar nucleolar JJ cord-007714-n3omlvfl 316 26 localization localization NN cord-007714-n3omlvfl 316 27 element element NN cord-007714-n3omlvfl 316 28 of of IN cord-007714-n3omlvfl 316 29 U6 U6 NNP cord-007714-n3omlvfl 316 30 snRNA snrna NN cord-007714-n3omlvfl 317 1 Single single JJ cord-007714-n3omlvfl 317 2 ribosomal ribosomal JJ cord-007714-n3omlvfl 317 3 transcription transcription NN cord-007714-n3omlvfl 317 4 units unit NNS cord-007714-n3omlvfl 317 5 are be VBP cord-007714-n3omlvfl 317 6 linear linear JJ cord-007714-n3omlvfl 317 7 , , , cord-007714-n3omlvfl 317 8 compacted compact VBD cord-007714-n3omlvfl 317 9 Christmas Christmas NNP cord-007714-n3omlvfl 317 10 trees tree NNS cord-007714-n3omlvfl 317 11 in in IN cord-007714-n3omlvfl 317 12 plant plant NN cord-007714-n3omlvfl 317 13 nucleoli nucleoli NNP cord-007714-n3omlvfl 318 1 The the DT cord-007714-n3omlvfl 318 2 road road NN cord-007714-n3omlvfl 318 3 much much RB cord-007714-n3omlvfl 318 4 travelled travel VBD cord-007714-n3omlvfl 318 5 : : : cord-007714-n3omlvfl 318 6 trafficking trafficking NN cord-007714-n3omlvfl 318 7 in in IN cord-007714-n3omlvfl 318 8 the the DT cord-007714-n3omlvfl 318 9 cell cell NN cord-007714-n3omlvfl 318 10 nucleus nucleus NN cord-007714-n3omlvfl 318 11 90S 90S NNP cord-007714-n3omlvfl 318 12 pre pre NNS cord-007714-n3omlvfl 318 13 - - NNS cord-007714-n3omlvfl 318 14 ribosomes ribosome NNS cord-007714-n3omlvfl 318 15 include include VBP cord-007714-n3omlvfl 318 16 the the DT cord-007714-n3omlvfl 318 17 35S 35S NNP cord-007714-n3omlvfl 318 18 pre pre NNP cord-007714-n3omlvfl 318 19 - - NNP cord-007714-n3omlvfl 318 20 rRNA rrna JJ cord-007714-n3omlvfl 318 21 , , , cord-007714-n3omlvfl 318 22 the the DT cord-007714-n3omlvfl 318 23 U3 U3 NNP cord-007714-n3omlvfl 318 24 snoRNP snornp NN cord-007714-n3omlvfl 318 25 , , , cord-007714-n3omlvfl 318 26 and and CC cord-007714-n3omlvfl 318 27 40S 40s CD cord-007714-n3omlvfl 318 28 subunit subunit NN cord-007714-n3omlvfl 318 29 processing processing NN cord-007714-n3omlvfl 318 30 factors factor NNS cord-007714-n3omlvfl 318 31 but but CC cord-007714-n3omlvfl 318 32 predominantly predominantly RB cord-007714-n3omlvfl 318 33 lack lack VBP cord-007714-n3omlvfl 318 34 60S 60s CD cord-007714-n3omlvfl 318 35 synthesis synthesis NN cord-007714-n3omlvfl 318 36 factors factor NNS cord-007714-n3omlvfl 318 37 Ribosome Ribosome NNP cord-007714-n3omlvfl 318 38 biogenesis biogenesis NN cord-007714-n3omlvfl 318 39 : : : cord-007714-n3omlvfl 318 40 of of IN cord-007714-n3omlvfl 318 41 knobs knob NNS cord-007714-n3omlvfl 318 42 and and CC cord-007714-n3omlvfl 318 43 RNA RNA NNP cord-007714-n3omlvfl 318 44 processing processing NN cord-007714-n3omlvfl 318 45 Crosstalk crosstalk NN cord-007714-n3omlvfl 318 46 in in IN cord-007714-n3omlvfl 318 47 gene gene NN cord-007714-n3omlvfl 318 48 expression expression NN cord-007714-n3omlvfl 318 49 : : : cord-007714-n3omlvfl 318 50 coupling coupling NN cord-007714-n3omlvfl 318 51 and and CC cord-007714-n3omlvfl 318 52 co co NN cord-007714-n3omlvfl 318 53 - - NN cord-007714-n3omlvfl 318 54 regulation regulation NN cord-007714-n3omlvfl 318 55 of of IN cord-007714-n3omlvfl 318 56 rDNA rDNA NNP cord-007714-n3omlvfl 318 57 transcription transcription NN cord-007714-n3omlvfl 318 58 , , , cord-007714-n3omlvfl 318 59 pre pre JJ cord-007714-n3omlvfl 318 60 - - JJ cord-007714-n3omlvfl 318 61 ribosome ribosome JJ cord-007714-n3omlvfl 318 62 assembly assembly NN cord-007714-n3omlvfl 318 63 and and CC cord-007714-n3omlvfl 318 64 pre pre JJ cord-007714-n3omlvfl 318 65 - - JJ cord-007714-n3omlvfl 318 66 rRNA rrna JJ cord-007714-n3omlvfl 318 67 processing processing NN cord-007714-n3omlvfl 318 68 Biogenesis biogenesis NN cord-007714-n3omlvfl 318 69 of of IN cord-007714-n3omlvfl 318 70 the the DT cord-007714-n3omlvfl 318 71 signal signal NN cord-007714-n3omlvfl 318 72 recognition recognition NN cord-007714-n3omlvfl 318 73 particle particle NN cord-007714-n3omlvfl 318 74 ( ( -LRB- cord-007714-n3omlvfl 318 75 SRP SRP NNP cord-007714-n3omlvfl 318 76 ) ) -RRB- cord-007714-n3omlvfl 318 77 involves involve VBZ cord-007714-n3omlvfl 318 78 import import NN cord-007714-n3omlvfl 318 79 of of IN cord-007714-n3omlvfl 318 80 SRP SRP NNP cord-007714-n3omlvfl 318 81 proteins protein NNS cord-007714-n3omlvfl 318 82 into into IN cord-007714-n3omlvfl 318 83 the the DT cord-007714-n3omlvfl 318 84 nucleolus nucleolus NN cord-007714-n3omlvfl 318 85 , , , cord-007714-n3omlvfl 318 86 assembly assembly NN cord-007714-n3omlvfl 318 87 with with IN cord-007714-n3omlvfl 318 88 SRP SRP NNP cord-007714-n3omlvfl 318 89 - - HYPH cord-007714-n3omlvfl 318 90 RNA RNA NNP cord-007714-n3omlvfl 318 91 , , , cord-007714-n3omlvfl 318 92 and and CC cord-007714-n3omlvfl 318 93 Xpo1p xpo1p RB cord-007714-n3omlvfl 318 94 - - HYPH cord-007714-n3omlvfl 318 95 mediated mediate VBN cord-007714-n3omlvfl 318 96 export export NN cord-007714-n3omlvfl 319 1 The the DT cord-007714-n3omlvfl 319 2 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 319 3 double double RB cord-007714-n3omlvfl 319 4 - - HYPH cord-007714-n3omlvfl 319 5 stranded strand VBN cord-007714-n3omlvfl 319 6 RNA rna NN cord-007714-n3omlvfl 319 7 - - HYPH cord-007714-n3omlvfl 319 8 binding bind VBG cord-007714-n3omlvfl 319 9 protein protein NN cord-007714-n3omlvfl 319 10 HYL1 HYL1 NNP cord-007714-n3omlvfl 319 11 plays play VBZ cord-007714-n3omlvfl 319 12 a a DT cord-007714-n3omlvfl 319 13 role role NN cord-007714-n3omlvfl 319 14 in in IN cord-007714-n3omlvfl 319 15 microRNA microRNA NNP cord-007714-n3omlvfl 319 16 - - HYPH cord-007714-n3omlvfl 319 17 mediated mediate VBN cord-007714-n3omlvfl 319 18 gene gene NN cord-007714-n3omlvfl 319 19 regulation regulation NN cord-007714-n3omlvfl 319 20 Subnuclear Subnuclear NNP cord-007714-n3omlvfl 319 21 organelles organelle NNS cord-007714-n3omlvfl 319 22 : : : cord-007714-n3omlvfl 319 23 new new JJ cord-007714-n3omlvfl 319 24 insights insight NNS cord-007714-n3omlvfl 319 25 into into IN cord-007714-n3omlvfl 319 26 form form NN cord-007714-n3omlvfl 319 27 and and CC cord-007714-n3omlvfl 319 28 function function NN cord-007714-n3omlvfl 319 29 SDE5 SDE5 NNP cord-007714-n3omlvfl 319 30 , , , cord-007714-n3omlvfl 319 31 the the DT cord-007714-n3omlvfl 319 32 putative putative JJ cord-007714-n3omlvfl 319 33 homologue homologue NN cord-007714-n3omlvfl 319 34 of of IN cord-007714-n3omlvfl 319 35 a a DT cord-007714-n3omlvfl 319 36 human human JJ cord-007714-n3omlvfl 319 37 mRNA mrna NN cord-007714-n3omlvfl 319 38 export export NN cord-007714-n3omlvfl 319 39 factor factor NN cord-007714-n3omlvfl 319 40 , , , cord-007714-n3omlvfl 319 41 is be VBZ cord-007714-n3omlvfl 319 42 required require VBN cord-007714-n3omlvfl 319 43 for for IN cord-007714-n3omlvfl 319 44 transgene transgene NN cord-007714-n3omlvfl 319 45 silencing silencing NN cord-007714-n3omlvfl 319 46 and and CC cord-007714-n3omlvfl 319 47 accumulation accumulation NN cord-007714-n3omlvfl 319 48 of of IN cord-007714-n3omlvfl 319 49 trans trans NNP cord-007714-n3omlvfl 319 50 -acting -acte VBG cord-007714-n3omlvfl 319 51 endogenous endogenous JJ cord-007714-n3omlvfl 319 52 siRNA siRNA NNP cord-007714-n3omlvfl 320 1 The the DT cord-007714-n3omlvfl 320 2 nucleolus nucleolus NN cord-007714-n3omlvfl 320 3 - - : cord-007714-n3omlvfl 320 4 a a DT cord-007714-n3omlvfl 320 5 gateway gateway NN cord-007714-n3omlvfl 320 6 to to IN cord-007714-n3omlvfl 320 7 viral viral JJ cord-007714-n3omlvfl 320 8 infection infection NN cord-007714-n3omlvfl 320 9 ? ? . cord-007714-n3omlvfl 321 1 RNA RNA NNP cord-007714-n3omlvfl 321 2 viruses virus NNS cord-007714-n3omlvfl 321 3 : : : cord-007714-n3omlvfl 322 1 hijacking hijack VBG cord-007714-n3omlvfl 322 2 the the DT cord-007714-n3omlvfl 322 3 dynamic dynamic JJ cord-007714-n3omlvfl 322 4 nucleolus nucleolus NN cord-007714-n3omlvfl 322 5 The the DT cord-007714-n3omlvfl 322 6 ins in NNS cord-007714-n3omlvfl 322 7 and and CC cord-007714-n3omlvfl 322 8 outs out NNS cord-007714-n3omlvfl 322 9 of of IN cord-007714-n3omlvfl 322 10 HIV HIV NNP cord-007714-n3omlvfl 322 11 tRNA tRNA NNP cord-007714-n3omlvfl 322 12 transfers transfer NNS cord-007714-n3omlvfl 322 13 to to IN cord-007714-n3omlvfl 322 14 the the DT cord-007714-n3omlvfl 322 15 limelight limelight NN cord-007714-n3omlvfl 322 16 UPF3 UPF3 NNP cord-007714-n3omlvfl 322 17 suppresses suppress VBZ cord-007714-n3omlvfl 322 18 aberrant aberrant JJ cord-007714-n3omlvfl 322 19 spliced splice VBN cord-007714-n3omlvfl 322 20 mRNA mrna NN cord-007714-n3omlvfl 322 21 in in IN cord-007714-n3omlvfl 322 22 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 323 1 The the DT cord-007714-n3omlvfl 323 2 nucleolus nucleolus NN cord-007714-n3omlvfl 323 3 is be VBZ cord-007714-n3omlvfl 323 4 involved involve VBN cord-007714-n3omlvfl 323 5 in in IN cord-007714-n3omlvfl 323 6 mRNA mRNA NNP cord-007714-n3omlvfl 323 7 export export NN cord-007714-n3omlvfl 323 8 from from IN cord-007714-n3omlvfl 323 9 the the DT cord-007714-n3omlvfl 323 10 nucleus nucleus NN cord-007714-n3omlvfl 323 11 in in IN cord-007714-n3omlvfl 323 12 fission fission NN cord-007714-n3omlvfl 323 13 yeast yeast NN cord-007714-n3omlvfl 323 14 Nuclear nuclear JJ cord-007714-n3omlvfl 323 15 domains domain NNS cord-007714-n3omlvfl 323 16 of of IN cord-007714-n3omlvfl 323 17 RNA RNA NNP cord-007714-n3omlvfl 323 18 subunit subunit NN cord-007714-n3omlvfl 323 19 of of IN cord-007714-n3omlvfl 323 20 RNase RNase NNP cord-007714-n3omlvfl 323 21 P P NNP cord-007714-n3omlvfl 323 22 Localization Localization NNP cord-007714-n3omlvfl 323 23 of of IN cord-007714-n3omlvfl 323 24 signal signal NN cord-007714-n3omlvfl 323 25 recognition recognition NN cord-007714-n3omlvfl 323 26 particle particle NN cord-007714-n3omlvfl 323 27 RNA RNA NNP cord-007714-n3omlvfl 323 28 in in IN cord-007714-n3omlvfl 323 29 the the DT cord-007714-n3omlvfl 323 30 nucleolus nucleolus NN cord-007714-n3omlvfl 323 31 of of IN cord-007714-n3omlvfl 323 32 mammalian mammalian JJ cord-007714-n3omlvfl 323 33 cells cell NNS cord-007714-n3omlvfl 323 34 Modification modification NN cord-007714-n3omlvfl 323 35 of of IN cord-007714-n3omlvfl 323 36 Sm sm JJ cord-007714-n3omlvfl 323 37 small small JJ cord-007714-n3omlvfl 323 38 nuclear nuclear JJ cord-007714-n3omlvfl 323 39 RNAs rna NNS cord-007714-n3omlvfl 323 40 occurs occur VBZ cord-007714-n3omlvfl 323 41 in in IN cord-007714-n3omlvfl 323 42 the the DT cord-007714-n3omlvfl 323 43 nucleoplasmic nucleoplasmic NNP cord-007714-n3omlvfl 323 44 Cajal Cajal NNP cord-007714-n3omlvfl 323 45 body body NN cord-007714-n3omlvfl 323 46 following follow VBG cord-007714-n3omlvfl 323 47 import import NN cord-007714-n3omlvfl 323 48 from from IN cord-007714-n3omlvfl 323 49 the the DT cord-007714-n3omlvfl 323 50 cytoplasm cytoplasm NN cord-007714-n3omlvfl 323 51 Human Human NNP cord-007714-n3omlvfl 323 52 telomerase telomerase NN cord-007714-n3omlvfl 323 53 RNA rna NN cord-007714-n3omlvfl 323 54 and and CC cord-007714-n3omlvfl 324 1 box box NNP cord-007714-n3omlvfl 324 2 H H NNP cord-007714-n3omlvfl 324 3 / / SYM cord-007714-n3omlvfl 324 4 ACA ACA NNP cord-007714-n3omlvfl 324 5 scaRNAs scaRNAs NNP cord-007714-n3omlvfl 324 6 share share VBP cord-007714-n3omlvfl 324 7 a a DT cord-007714-n3omlvfl 324 8 common common JJ cord-007714-n3omlvfl 324 9 Cajal Cajal NNP cord-007714-n3omlvfl 324 10 body body NN cord-007714-n3omlvfl 324 11 - - HYPH cord-007714-n3omlvfl 324 12 specific specific JJ cord-007714-n3omlvfl 324 13 localization localization NN cord-007714-n3omlvfl 324 14 signal signal NN cord-007714-n3omlvfl 324 15 Localisation Localisation NNP cord-007714-n3omlvfl 324 16 in in IN cord-007714-n3omlvfl 324 17 the the DT cord-007714-n3omlvfl 324 18 nucleolus nucleolus NN cord-007714-n3omlvfl 324 19 and and CC cord-007714-n3omlvfl 324 20 coiled coiled JJ cord-007714-n3omlvfl 324 21 bodies body NNS cord-007714-n3omlvfl 324 22 of of IN cord-007714-n3omlvfl 324 23 protein protein NN cord-007714-n3omlvfl 324 24 subunits subunit NNS cord-007714-n3omlvfl 324 25 of of IN cord-007714-n3omlvfl 324 26 the the DT cord-007714-n3omlvfl 324 27 ribonucleoprotein ribonucleoprotein NN cord-007714-n3omlvfl 324 28 ribonuclease ribonuclease NN cord-007714-n3omlvfl 324 29 P p NN cord-007714-n3omlvfl 324 30 Mutations Mutations NNPS cord-007714-n3omlvfl 324 31 in in IN cord-007714-n3omlvfl 324 32 nucleolar nucleolar JJ cord-007714-n3omlvfl 324 33 proteins protein NNS cord-007714-n3omlvfl 324 34 lead lead VBP cord-007714-n3omlvfl 324 35 to to IN cord-007714-n3omlvfl 324 36 nucleolar nucleolar JJ cord-007714-n3omlvfl 324 37 accumulation accumulation NN cord-007714-n3omlvfl 324 38 of of IN cord-007714-n3omlvfl 324 39 poly(A poly(A NNP cord-007714-n3omlvfl 324 40 ) ) -RRB- cord-007714-n3omlvfl 325 1 + + CC cord-007714-n3omlvfl 325 2 RNA RNA NNP cord-007714-n3omlvfl 325 3 in in IN cord-007714-n3omlvfl 325 4 Saccharomyces Saccharomyces NNP cord-007714-n3omlvfl 325 5 cerevisiae cerevisiae NNS cord-007714-n3omlvfl 326 1 Both both DT cord-007714-n3omlvfl 326 2 introns intron NNS cord-007714-n3omlvfl 326 3 and and CC cord-007714-n3omlvfl 326 4 long long JJ cord-007714-n3omlvfl 326 5 3′-UTRs 3′-utrs CD cord-007714-n3omlvfl 326 6 operate operate NN cord-007714-n3omlvfl 326 7 as as IN cord-007714-n3omlvfl 326 8 cis cis NNP cord-007714-n3omlvfl 326 9 -acting -acte VBG cord-007714-n3omlvfl 326 10 elements element NNS cord-007714-n3omlvfl 326 11 to to TO cord-007714-n3omlvfl 326 12 trigger trigger VB cord-007714-n3omlvfl 326 13 nonsense nonsense NN cord-007714-n3omlvfl 326 14 - - HYPH cord-007714-n3omlvfl 326 15 mediated mediate VBN cord-007714-n3omlvfl 326 16 decay decay NN cord-007714-n3omlvfl 326 17 in in IN cord-007714-n3omlvfl 326 18 plants plant NNS cord-007714-n3omlvfl 327 1 Cajal cajal NN cord-007714-n3omlvfl 327 2 bodies body NNS cord-007714-n3omlvfl 327 3 , , , cord-007714-n3omlvfl 327 4 the the DT cord-007714-n3omlvfl 327 5 nucleolus nucleolus NN cord-007714-n3omlvfl 327 6 and and CC cord-007714-n3omlvfl 327 7 fibrillarin fibrillarin NNP cord-007714-n3omlvfl 327 8 are be VBP cord-007714-n3omlvfl 327 9 required require VBN cord-007714-n3omlvfl 327 10 for for IN cord-007714-n3omlvfl 327 11 a a DT cord-007714-n3omlvfl 327 12 plant plant NN cord-007714-n3omlvfl 327 13 virus virus NN cord-007714-n3omlvfl 327 14 systemic systemic JJ cord-007714-n3omlvfl 327 15 infection infection NN cord-007714-n3omlvfl 327 16 Interaction Interaction NNP cord-007714-n3omlvfl 327 17 of of IN cord-007714-n3omlvfl 327 18 a a DT cord-007714-n3omlvfl 327 19 plant plant NN cord-007714-n3omlvfl 327 20 virus virus NN cord-007714-n3omlvfl 327 21 - - HYPH cord-007714-n3omlvfl 327 22 encoded encode VBN cord-007714-n3omlvfl 327 23 protein protein NN cord-007714-n3omlvfl 327 24 with with IN cord-007714-n3omlvfl 327 25 the the DT cord-007714-n3omlvfl 327 26 major major JJ cord-007714-n3omlvfl 327 27 nucleolar nucleolar JJ cord-007714-n3omlvfl 327 28 protein protein NN cord-007714-n3omlvfl 327 29 fibrillarin fibrillarin NNP cord-007714-n3omlvfl 327 30 is be VBZ cord-007714-n3omlvfl 327 31 required require VBN cord-007714-n3omlvfl 327 32 for for IN cord-007714-n3omlvfl 327 33 systemic systemic JJ cord-007714-n3omlvfl 327 34 virus virus NN cord-007714-n3omlvfl 327 35 infection infection NN cord-007714-n3omlvfl 327 36 Nucleocytoplasmic Nucleocytoplasmic NNP cord-007714-n3omlvfl 327 37 partitioning partitioning NN cord-007714-n3omlvfl 327 38 of of IN cord-007714-n3omlvfl 327 39 the the DT cord-007714-n3omlvfl 327 40 plant plant NN cord-007714-n3omlvfl 327 41 photoreceptors photoreceptor NNS cord-007714-n3omlvfl 327 42 phytochrome phytochrome NN cord-007714-n3omlvfl 327 43 A A NNP cord-007714-n3omlvfl 327 44 , , , cord-007714-n3omlvfl 327 45 B B NNP cord-007714-n3omlvfl 327 46 , , , cord-007714-n3omlvfl 327 47 C C NNP cord-007714-n3omlvfl 327 48 , , , cord-007714-n3omlvfl 327 49 D D NNP cord-007714-n3omlvfl 327 50 , , , cord-007714-n3omlvfl 327 51 and and CC cord-007714-n3omlvfl 327 52 E E NNP cord-007714-n3omlvfl 327 53 is be VBZ cord-007714-n3omlvfl 327 54 regulated regulate VBN cord-007714-n3omlvfl 327 55 differentially differentially RB cord-007714-n3omlvfl 327 56 by by IN cord-007714-n3omlvfl 327 57 light light NN cord-007714-n3omlvfl 327 58 and and CC cord-007714-n3omlvfl 327 59 exhibits exhibit VBZ cord-007714-n3omlvfl 327 60 a a DT cord-007714-n3omlvfl 327 61 diurnal diurnal JJ cord-007714-n3omlvfl 327 62 rhythm rhythm NN cord-007714-n3omlvfl 327 63 Small small JJ cord-007714-n3omlvfl 327 64 nucleolar nucleolar JJ cord-007714-n3omlvfl 327 65 RNAs rna NNS cord-007714-n3omlvfl 327 66 : : : cord-007714-n3omlvfl 327 67 An an DT cord-007714-n3omlvfl 327 68 abundant abundant JJ cord-007714-n3omlvfl 327 69 group group NN cord-007714-n3omlvfl 327 70 of of IN cord-007714-n3omlvfl 327 71 non non JJ cord-007714-n3omlvfl 327 72 - - JJ cord-007714-n3omlvfl 327 73 coding coding JJ cord-007714-n3omlvfl 327 74 RNAs rna NNS cord-007714-n3omlvfl 327 75 with with IN cord-007714-n3omlvfl 327 76 diverse diverse JJ cord-007714-n3omlvfl 327 77 cellular cellular JJ cord-007714-n3omlvfl 327 78 functions function NNS cord-007714-n3omlvfl 327 79 Transient transient JJ cord-007714-n3omlvfl 327 80 nucleolar nucleolar JJ cord-007714-n3omlvfl 327 81 localization localization NN cord-007714-n3omlvfl 327 82 of of IN cord-007714-n3omlvfl 327 83 U6 U6 NNP cord-007714-n3omlvfl 327 84 small small JJ cord-007714-n3omlvfl 327 85 nuclear nuclear JJ cord-007714-n3omlvfl 327 86 RNA RNA NNP cord-007714-n3omlvfl 327 87 in in IN cord-007714-n3omlvfl 327 88 Xenopus Xenopus NNP cord-007714-n3omlvfl 327 89 laevis laevi NNS cord-007714-n3omlvfl 327 90 oocytes oocyte NNS cord-007714-n3omlvfl 327 91 Nuclear nuclear JJ cord-007714-n3omlvfl 327 92 speckles speckle NNS cord-007714-n3omlvfl 327 93 : : : cord-007714-n3omlvfl 327 94 a a DT cord-007714-n3omlvfl 327 95 model model NN cord-007714-n3omlvfl 327 96 for for IN cord-007714-n3omlvfl 327 97 nuclear nuclear JJ cord-007714-n3omlvfl 327 98 organelles organelle NNS cord-007714-n3omlvfl 327 99 Mechanistic mechanistic JJ cord-007714-n3omlvfl 327 100 links link NNS cord-007714-n3omlvfl 327 101 between between IN cord-007714-n3omlvfl 327 102 nonsense nonsense NN cord-007714-n3omlvfl 327 103 - - HYPH cord-007714-n3omlvfl 327 104 mediated mediate VBN cord-007714-n3omlvfl 327 105 mRNA mrna NN cord-007714-n3omlvfl 327 106 decay decay NN cord-007714-n3omlvfl 327 107 and and CC cord-007714-n3omlvfl 327 108 pre pre JJ cord-007714-n3omlvfl 327 109 - - JJ cord-007714-n3omlvfl 327 110 mRNA mrna JJ cord-007714-n3omlvfl 327 111 splicing splicing NN cord-007714-n3omlvfl 327 112 in in IN cord-007714-n3omlvfl 327 113 mammalian mammalian JJ cord-007714-n3omlvfl 327 114 cells cell NNS cord-007714-n3omlvfl 328 1 The the DT cord-007714-n3omlvfl 328 2 dynamics dynamic NNS cord-007714-n3omlvfl 328 3 of of IN cord-007714-n3omlvfl 328 4 the the DT cord-007714-n3omlvfl 328 5 nucleolus nucleolus NN cord-007714-n3omlvfl 328 6 Quantitative Quantitative NNP cord-007714-n3omlvfl 328 7 kinetic kinetic JJ cord-007714-n3omlvfl 328 8 analysis analysis NN cord-007714-n3omlvfl 328 9 of of IN cord-007714-n3omlvfl 328 10 nucleolar nucleolar JJ cord-007714-n3omlvfl 328 11 breakdown breakdown NN cord-007714-n3omlvfl 328 12 and and CC cord-007714-n3omlvfl 328 13 reassembly reassembly NN cord-007714-n3omlvfl 328 14 during during IN cord-007714-n3omlvfl 328 15 mitosis mitosis NN cord-007714-n3omlvfl 328 16 in in IN cord-007714-n3omlvfl 328 17 live live JJ cord-007714-n3omlvfl 328 18 human human JJ cord-007714-n3omlvfl 328 19 cells cell NNS cord-007714-n3omlvfl 329 1 An an DT cord-007714-n3omlvfl 329 2 ARGONAUTE4-containing argonaute4-containe VBG cord-007714-n3omlvfl 329 3 nuclear nuclear JJ cord-007714-n3omlvfl 329 4 processing processing NN cord-007714-n3omlvfl 329 5 center center NN cord-007714-n3omlvfl 329 6 colocalized colocalize VBN cord-007714-n3omlvfl 329 7 with with IN cord-007714-n3omlvfl 329 8 Cajal Cajal NNP cord-007714-n3omlvfl 329 9 bodies body NNS cord-007714-n3omlvfl 329 10 in in IN cord-007714-n3omlvfl 329 11 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 329 12 thaliana thaliana NN cord-007714-n3omlvfl 329 13 Modulation modulation NN cord-007714-n3omlvfl 329 14 of of IN cord-007714-n3omlvfl 329 15 an an DT cord-007714-n3omlvfl 329 16 RNA rna NN cord-007714-n3omlvfl 329 17 - - HYPH cord-007714-n3omlvfl 329 18 binding bind VBG cord-007714-n3omlvfl 329 19 protein protein NN cord-007714-n3omlvfl 329 20 by by IN cord-007714-n3omlvfl 329 21 abscisic abscisic NN cord-007714-n3omlvfl 329 22 - - HYPH cord-007714-n3omlvfl 329 23 acid acid NN cord-007714-n3omlvfl 329 24 - - HYPH cord-007714-n3omlvfl 329 25 activated activate VBN cord-007714-n3omlvfl 329 26 protein protein NN cord-007714-n3omlvfl 329 27 kinase kinase NN cord-007714-n3omlvfl 329 28 The the DT cord-007714-n3omlvfl 329 29 Ref Ref NNP cord-007714-n3omlvfl 329 30 / / SYM cord-007714-n3omlvfl 329 31 Aly Aly NNP cord-007714-n3omlvfl 329 32 proteins protein NNS cord-007714-n3omlvfl 329 33 are be VBP cord-007714-n3omlvfl 329 34 dispensable dispensable JJ cord-007714-n3omlvfl 329 35 for for IN cord-007714-n3omlvfl 329 36 mRNA mRNA NNP cord-007714-n3omlvfl 329 37 export export NN cord-007714-n3omlvfl 329 38 and and CC cord-007714-n3omlvfl 329 39 development development NN cord-007714-n3omlvfl 329 40 in in IN cord-007714-n3omlvfl 329 41 Caenorhabditis Caenorhabditis NNP cord-007714-n3omlvfl 329 42 elegans elegan NNS cord-007714-n3omlvfl 329 43 Use Use NNP cord-007714-n3omlvfl 329 44 of of IN cord-007714-n3omlvfl 329 45 fluorescent fluorescent JJ cord-007714-n3omlvfl 329 46 protein protein NN cord-007714-n3omlvfl 329 47 tags tag NNS cord-007714-n3omlvfl 329 48 to to TO cord-007714-n3omlvfl 329 49 study study VB cord-007714-n3omlvfl 329 50 nuclear nuclear JJ cord-007714-n3omlvfl 329 51 organisation organisation NN cord-007714-n3omlvfl 329 52 of of IN cord-007714-n3omlvfl 329 53 the the DT cord-007714-n3omlvfl 329 54 spliceosomal spliceosomal NNP cord-007714-n3omlvfl 329 55 machinery machinery NN cord-007714-n3omlvfl 329 56 in in IN cord-007714-n3omlvfl 329 57 transiently transiently RB cord-007714-n3omlvfl 329 58 transformed transform VBN cord-007714-n3omlvfl 329 59 living live VBG cord-007714-n3omlvfl 329 60 plant plant NN cord-007714-n3omlvfl 329 61 cells cell NNS cord-007714-n3omlvfl 330 1 The the DT cord-007714-n3omlvfl 330 2 snoRNA snoRNA NNP cord-007714-n3omlvfl 330 3 domain domain NN cord-007714-n3omlvfl 330 4 of of IN cord-007714-n3omlvfl 330 5 vertebrate vertebrate JJ cord-007714-n3omlvfl 330 6 telomerase telomerase NN cord-007714-n3omlvfl 330 7 RNA RNA NNP cord-007714-n3omlvfl 330 8 functions function NNS cord-007714-n3omlvfl 330 9 to to TO cord-007714-n3omlvfl 330 10 localize localize VB cord-007714-n3omlvfl 330 11 the the DT cord-007714-n3omlvfl 330 12 RNA RNA NNP cord-007714-n3omlvfl 330 13 within within IN cord-007714-n3omlvfl 330 14 the the DT cord-007714-n3omlvfl 330 15 nucleus nucleus NN cord-007714-n3omlvfl 330 16 UAP56 UAP56 NNP cord-007714-n3omlvfl 330 17 levels level NNS cord-007714-n3omlvfl 330 18 affect affect VBP cord-007714-n3omlvfl 330 19 viability viability NN cord-007714-n3omlvfl 330 20 and and CC cord-007714-n3omlvfl 330 21 mRNA mrna NN cord-007714-n3omlvfl 330 22 export export NN cord-007714-n3omlvfl 330 23 in in IN cord-007714-n3omlvfl 330 24 Caenorhabditis Caenorhabditis NNP cord-007714-n3omlvfl 330 25 elegans elegan NNS cord-007714-n3omlvfl 331 1 Nonsense nonsense NN cord-007714-n3omlvfl 331 2 - - HYPH cord-007714-n3omlvfl 331 3 mediated mediate VBN cord-007714-n3omlvfl 331 4 mRNA mrna NN cord-007714-n3omlvfl 331 5 decay decay NN cord-007714-n3omlvfl 331 6 : : : cord-007714-n3omlvfl 331 7 splicing splicing NN cord-007714-n3omlvfl 331 8 , , , cord-007714-n3omlvfl 331 9 translation translation NN cord-007714-n3omlvfl 331 10 and and CC cord-007714-n3omlvfl 331 11 mRNA mRNA NNP cord-007714-n3omlvfl 331 12 dynamics dynamic NNS cord-007714-n3omlvfl 331 13 Experimental Experimental NNP cord-007714-n3omlvfl 331 14 RNomics RNomics NNPS cord-007714-n3omlvfl 332 1 : : : cord-007714-n3omlvfl 332 2 identification identification NN cord-007714-n3omlvfl 332 3 of of IN cord-007714-n3omlvfl 332 4 140 140 CD cord-007714-n3omlvfl 332 5 candidates candidate NNS cord-007714-n3omlvfl 332 6 for for IN cord-007714-n3omlvfl 332 7 small small JJ cord-007714-n3omlvfl 332 8 non non JJ cord-007714-n3omlvfl 332 9 - - JJ cord-007714-n3omlvfl 332 10 messenger messenger JJ cord-007714-n3omlvfl 332 11 RNAs rna NNS cord-007714-n3omlvfl 332 12 in in IN cord-007714-n3omlvfl 332 13 the the DT cord-007714-n3omlvfl 332 14 plant plant NN cord-007714-n3omlvfl 332 15 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 332 16 thaliana thaliana NN cord-007714-n3omlvfl 332 17 Connecting connect VBG cord-007714-n3omlvfl 332 18 chromosomes chromosome NNS cord-007714-n3omlvfl 332 19 Nuclear nuclear JJ cord-007714-n3omlvfl 332 20 bodies body NNS cord-007714-n3omlvfl 332 21 : : : cord-007714-n3omlvfl 332 22 multifaceted multifaceted JJ cord-007714-n3omlvfl 332 23 subdomains subdomain NNS cord-007714-n3omlvfl 332 24 of of IN cord-007714-n3omlvfl 332 25 the the DT cord-007714-n3omlvfl 332 26 interchromatin interchromatin NNP cord-007714-n3omlvfl 332 27 space space NN cord-007714-n3omlvfl 332 28 Ribozyme Ribozyme NNPS cord-007714-n3omlvfl 332 29 - - HYPH cord-007714-n3omlvfl 332 30 mediated mediate VBN cord-007714-n3omlvfl 332 31 inhibition inhibition NN cord-007714-n3omlvfl 332 32 of of IN cord-007714-n3omlvfl 332 33 HIV HIV NNP cord-007714-n3omlvfl 332 34 1 1 CD cord-007714-n3omlvfl 332 35 suggests suggest VBZ cord-007714-n3omlvfl 332 36 nucleolar nucleolar JJ cord-007714-n3omlvfl 332 37 trafficking trafficking NN cord-007714-n3omlvfl 332 38 of of IN cord-007714-n3omlvfl 332 39 HIV-1 HIV-1 NNP cord-007714-n3omlvfl 332 40 RNA RNA NNP cord-007714-n3omlvfl 332 41 Visualisation Visualisation NNP cord-007714-n3omlvfl 332 42 of of IN cord-007714-n3omlvfl 332 43 nucleolar nucleolar JJ cord-007714-n3omlvfl 332 44 genes gene NNS cord-007714-n3omlvfl 332 45 Concepts Concepts NNPS cord-007714-n3omlvfl 332 46 in in IN cord-007714-n3omlvfl 332 47 nuclear nuclear JJ cord-007714-n3omlvfl 332 48 architecture architecture NN cord-007714-n3omlvfl 333 1 A a DT cord-007714-n3omlvfl 333 2 box box NN cord-007714-n3omlvfl 333 3 H H NNP cord-007714-n3omlvfl 333 4 / / SYM cord-007714-n3omlvfl 333 5 ACA ACA NNP cord-007714-n3omlvfl 333 6 small small JJ cord-007714-n3omlvfl 333 7 nucleolar nucleolar NNS cord-007714-n3omlvfl 333 8 RNA RNA NNP cord-007714-n3omlvfl 333 9 - - HYPH cord-007714-n3omlvfl 333 10 like like JJ cord-007714-n3omlvfl 333 11 domain domain NN cord-007714-n3omlvfl 333 12 at at IN cord-007714-n3omlvfl 333 13 the the DT cord-007714-n3omlvfl 333 14 human human JJ cord-007714-n3omlvfl 333 15 telomerase telomerase NN cord-007714-n3omlvfl 333 16 RNA RNA NNP cord-007714-n3omlvfl 333 17 3′ 3′ CD cord-007714-n3omlvfl 333 18 end end NN cord-007714-n3omlvfl 334 1 Human human JJ cord-007714-n3omlvfl 334 2 telomerase telomerase NN cord-007714-n3omlvfl 334 3 activation activation NN cord-007714-n3omlvfl 334 4 requires require VBZ cord-007714-n3omlvfl 334 5 two two CD cord-007714-n3omlvfl 334 6 independent independent JJ cord-007714-n3omlvfl 334 7 interactions interaction NNS cord-007714-n3omlvfl 334 8 between between IN cord-007714-n3omlvfl 334 9 telomerase telomerase NN cord-007714-n3omlvfl 334 10 RNA rna NN cord-007714-n3omlvfl 334 11 and and CC cord-007714-n3omlvfl 334 12 telomerase telomerase NN cord-007714-n3omlvfl 334 13 reverse reverse NN cord-007714-n3omlvfl 334 14 transcriptase transcriptase NN cord-007714-n3omlvfl 334 15 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 334 16 ultrastructure ultrastructure NN cord-007714-n3omlvfl 334 17 in in IN cord-007714-n3omlvfl 334 18 vertebrates vertebrate NNS cord-007714-n3omlvfl 334 19 Role role NN cord-007714-n3omlvfl 334 20 of of IN cord-007714-n3omlvfl 334 21 the the DT cord-007714-n3omlvfl 334 22 box box NN cord-007714-n3omlvfl 334 23 C C NNP cord-007714-n3omlvfl 334 24 / / SYM cord-007714-n3omlvfl 334 25 D d NN cord-007714-n3omlvfl 334 26 motif motif NN cord-007714-n3omlvfl 334 27 in in IN cord-007714-n3omlvfl 334 28 localization localization NN cord-007714-n3omlvfl 334 29 of of IN cord-007714-n3omlvfl 334 30 small small JJ cord-007714-n3omlvfl 334 31 nucleolar nucleolar JJ cord-007714-n3omlvfl 334 32 RNAs rna NNS cord-007714-n3omlvfl 334 33 to to IN cord-007714-n3omlvfl 334 34 coiled coiled JJ cord-007714-n3omlvfl 334 35 bodies body NNS cord-007714-n3omlvfl 334 36 and and CC cord-007714-n3omlvfl 334 37 nucleoli nucleoli NNP cord-007714-n3omlvfl 334 38 The the DT cord-007714-n3omlvfl 334 39 nucleolus nucleolus NN cord-007714-n3omlvfl 334 40 : : : cord-007714-n3omlvfl 334 41 an an DT cord-007714-n3omlvfl 334 42 old old JJ cord-007714-n3omlvfl 334 43 factory factory NN cord-007714-n3omlvfl 334 44 with with IN cord-007714-n3omlvfl 334 45 unexpected unexpected JJ cord-007714-n3omlvfl 334 46 capabilities capability NNS cord-007714-n3omlvfl 334 47 Non non JJ cord-007714-n3omlvfl 334 48 - - JJ cord-007714-n3omlvfl 334 49 traditional traditional JJ cord-007714-n3omlvfl 334 50 roles role NNS cord-007714-n3omlvfl 334 51 of of IN cord-007714-n3omlvfl 334 52 the the DT cord-007714-n3omlvfl 334 53 nucleolus nucleolus NN cord-007714-n3omlvfl 334 54 . . . cord-007714-n3omlvfl 335 1 In in IN cord-007714-n3omlvfl 335 2 : : : cord-007714-n3omlvfl 335 3 The the DT cord-007714-n3omlvfl 335 4 Nucleolus Nucleolus NNP cord-007714-n3omlvfl 335 5 An An NNP cord-007714-n3omlvfl 335 6 eiF4AIII eif4aiii NN cord-007714-n3omlvfl 335 7 - - HYPH cord-007714-n3omlvfl 335 8 containiung containiung NN cord-007714-n3omlvfl 335 9 complex complex NN cord-007714-n3omlvfl 335 10 required require VBN cord-007714-n3omlvfl 335 11 for for IN cord-007714-n3omlvfl 335 12 mRNA mrna NN cord-007714-n3omlvfl 335 13 localization localization NN cord-007714-n3omlvfl 335 14 and and CC cord-007714-n3omlvfl 335 15 nonsense nonsense NN cord-007714-n3omlvfl 335 16 - - HYPH cord-007714-n3omlvfl 335 17 mediated mediate VBN cord-007714-n3omlvfl 335 18 decay decay NN cord-007714-n3omlvfl 336 1 The the DT cord-007714-n3omlvfl 336 2 plurifunctional plurifunctional JJ cord-007714-n3omlvfl 336 3 nucleolus nucleolus NN cord-007714-n3omlvfl 336 4 Proteomic Proteomic NNP cord-007714-n3omlvfl 336 5 analysis analysis NN cord-007714-n3omlvfl 336 6 of of IN cord-007714-n3omlvfl 336 7 the the DT cord-007714-n3omlvfl 336 8 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 336 9 nucleolus nucleolus NN cord-007714-n3omlvfl 336 10 suggests suggest VBZ cord-007714-n3omlvfl 336 11 novel novel NN cord-007714-n3omlvfl 336 12 nucleolar nucleolar JJ cord-007714-n3omlvfl 336 13 functions function NNS cord-007714-n3omlvfl 336 14 Purified purify VBN cord-007714-n3omlvfl 336 15 U7 U7 NNP cord-007714-n3omlvfl 336 16 snRNPs snRNPs NNP cord-007714-n3omlvfl 336 17 lack lack VBP cord-007714-n3omlvfl 336 18 the the DT cord-007714-n3omlvfl 336 19 Sm sm NN cord-007714-n3omlvfl 336 20 proteins protein NNS cord-007714-n3omlvfl 336 21 D1 d1 NN cord-007714-n3omlvfl 336 22 andD2 andD2 , cord-007714-n3omlvfl 336 23 but but CC cord-007714-n3omlvfl 336 24 contain contain VBP cord-007714-n3omlvfl 336 25 Lsm10 Lsm10 NNP cord-007714-n3omlvfl 336 26 , , , cord-007714-n3omlvfl 336 27 a a DT cord-007714-n3omlvfl 336 28 new new JJ cord-007714-n3omlvfl 336 29 14 14 CD cord-007714-n3omlvfl 336 30 kDa kDa NNP cord-007714-n3omlvfl 336 31 Sm Sm NNP cord-007714-n3omlvfl 336 32 D1-like D1-like NNP cord-007714-n3omlvfl 336 33 protein protein NN cord-007714-n3omlvfl 336 34 A a DT cord-007714-n3omlvfl 336 35 nonribosomal nonribosomal JJ cord-007714-n3omlvfl 336 36 landscape landscape NN cord-007714-n3omlvfl 336 37 in in IN cord-007714-n3omlvfl 336 38 the the DT cord-007714-n3omlvfl 336 39 nucleolus nucleolus NN cord-007714-n3omlvfl 336 40 revealed reveal VBN cord-007714-n3omlvfl 336 41 by by IN cord-007714-n3omlvfl 336 42 the the DT cord-007714-n3omlvfl 336 43 stem stem NN cord-007714-n3omlvfl 336 44 cell cell NN cord-007714-n3omlvfl 336 45 protein protein NN cord-007714-n3omlvfl 336 46 nucleostemin nucleostemin NNP cord-007714-n3omlvfl 337 1 The the DT cord-007714-n3omlvfl 337 2 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 337 3 chromatin chromatin NN cord-007714-n3omlvfl 337 4 - - HYPH cord-007714-n3omlvfl 337 5 modifying modify VBG cord-007714-n3omlvfl 337 6 nuclear nuclear JJ cord-007714-n3omlvfl 337 7 siRNA siRNA NNP cord-007714-n3omlvfl 337 8 pathway pathway NN cord-007714-n3omlvfl 337 9 involves involve VBZ cord-007714-n3omlvfl 337 10 a a DT cord-007714-n3omlvfl 337 11 nucleolar nucleolar JJ cord-007714-n3omlvfl 337 12 RNA RNA NNP cord-007714-n3omlvfl 337 13 processing processing NN cord-007714-n3omlvfl 337 14 center center NN cord-007714-n3omlvfl 337 15 Characterization characterization NN cord-007714-n3omlvfl 337 16 of of IN cord-007714-n3omlvfl 337 17 AtNUC AtNUC NNP cord-007714-n3omlvfl 337 18 - - HYPH cord-007714-n3omlvfl 337 19 L1 L1 NNP cord-007714-n3omlvfl 337 20 reveals reveal VBZ cord-007714-n3omlvfl 337 21 a a DT cord-007714-n3omlvfl 337 22 central central JJ cord-007714-n3omlvfl 337 23 role role NN cord-007714-n3omlvfl 337 24 of of IN cord-007714-n3omlvfl 337 25 nucleolin nucleolin NNP cord-007714-n3omlvfl 337 26 in in IN cord-007714-n3omlvfl 337 27 nucleolus nucleolus NNP cord-007714-n3omlvfl 337 28 organization organization NN cord-007714-n3omlvfl 337 29 and and CC cord-007714-n3omlvfl 337 30 silencing silencing NN cord-007714-n3omlvfl 337 31 of of IN cord-007714-n3omlvfl 337 32 AtNUC AtNUC NNP cord-007714-n3omlvfl 337 33 - - HYPH cord-007714-n3omlvfl 337 34 L2 l2 NN cord-007714-n3omlvfl 337 35 gene gene NN cord-007714-n3omlvfl 337 36 in in IN cord-007714-n3omlvfl 337 37 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 337 38 Identification Identification NNP cord-007714-n3omlvfl 337 39 of of IN cord-007714-n3omlvfl 337 40 10 10 CD cord-007714-n3omlvfl 337 41 novel novel NN cord-007714-n3omlvfl 337 42 snoRNA snoRNA NNP cord-007714-n3omlvfl 337 43 gene gene NN cord-007714-n3omlvfl 337 44 clusters cluster NNS cord-007714-n3omlvfl 337 45 from from IN cord-007714-n3omlvfl 337 46 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 337 47 thaliana thaliana NN cord-007714-n3omlvfl 338 1 A a DT cord-007714-n3omlvfl 338 2 conserved conserved JJ cord-007714-n3omlvfl 338 3 mRNA mrna NN cord-007714-n3omlvfl 338 4 export export NN cord-007714-n3omlvfl 338 5 machinery machinery NN cord-007714-n3omlvfl 338 6 coupled couple VBN cord-007714-n3omlvfl 338 7 to to TO cord-007714-n3omlvfl 338 8 pre pre VB cord-007714-n3omlvfl 338 9 - - JJ cord-007714-n3omlvfl 338 10 mRNA mrna JJ cord-007714-n3omlvfl 338 11 splicing splicing NN cord-007714-n3omlvfl 338 12 TREX TREX NNP cord-007714-n3omlvfl 338 13 , , , cord-007714-n3omlvfl 338 14 SR SR NNP cord-007714-n3omlvfl 338 15 proteins protein NNS cord-007714-n3omlvfl 338 16 and and CC cord-007714-n3omlvfl 338 17 export export NN cord-007714-n3omlvfl 338 18 of of IN cord-007714-n3omlvfl 338 19 mRNA mRNA NNP cord-007714-n3omlvfl 338 20 Structure Structure NNP cord-007714-n3omlvfl 338 21 and and CC cord-007714-n3omlvfl 338 22 function function NN cord-007714-n3omlvfl 338 23 of of IN cord-007714-n3omlvfl 338 24 the the DT cord-007714-n3omlvfl 338 25 nucleolus nucleolus NN cord-007714-n3omlvfl 338 26 in in IN cord-007714-n3omlvfl 338 27 the the DT cord-007714-n3omlvfl 338 28 spotlight spotlight NN cord-007714-n3omlvfl 338 29 Disruption disruption NN cord-007714-n3omlvfl 338 30 of of IN cord-007714-n3omlvfl 338 31 the the DT cord-007714-n3omlvfl 338 32 nucleolus nucleolus NN cord-007714-n3omlvfl 338 33 mediates mediate VBZ cord-007714-n3omlvfl 338 34 stabilisation stabilisation NN cord-007714-n3omlvfl 338 35 of of IN cord-007714-n3omlvfl 338 36 p53 p53 NN cord-007714-n3omlvfl 338 37 in in IN cord-007714-n3omlvfl 338 38 response response NN cord-007714-n3omlvfl 338 39 to to IN cord-007714-n3omlvfl 338 40 DNA dna NN cord-007714-n3omlvfl 338 41 damage damage NN cord-007714-n3omlvfl 338 42 and and CC cord-007714-n3omlvfl 338 43 other other JJ cord-007714-n3omlvfl 338 44 stresses stress NNS cord-007714-n3omlvfl 339 1 A a DT cord-007714-n3omlvfl 339 2 plant plant NN cord-007714-n3omlvfl 339 3 snoRNP snornp NN cord-007714-n3omlvfl 339 4 complex complex NN cord-007714-n3omlvfl 339 5 containing contain VBG cord-007714-n3omlvfl 339 6 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 339 7 , , , cord-007714-n3omlvfl 339 8 fibrillarin fibrillarin NNP cord-007714-n3omlvfl 339 9 and and CC cord-007714-n3omlvfl 339 10 nucleolin nucleolin NN cord-007714-n3omlvfl 339 11 - - HYPH cord-007714-n3omlvfl 339 12 like like JJ cord-007714-n3omlvfl 339 13 proteins protein NNS cord-007714-n3omlvfl 339 14 is be VBZ cord-007714-n3omlvfl 339 15 competent competent JJ cord-007714-n3omlvfl 339 16 for for IN cord-007714-n3omlvfl 339 17 both both DT cord-007714-n3omlvfl 339 18 rRNA rRNA NNP cord-007714-n3omlvfl 339 19 gene gene NN cord-007714-n3omlvfl 339 20 binding bind VBG cord-007714-n3omlvfl 339 21 and and CC cord-007714-n3omlvfl 339 22 pre pre JJ cord-007714-n3omlvfl 339 23 - - JJ cord-007714-n3omlvfl 339 24 rRNA rrna JJ cord-007714-n3omlvfl 339 25 processing processing NN cord-007714-n3omlvfl 339 26 in in IN cord-007714-n3omlvfl 339 27 vitro vitro FW cord-007714-n3omlvfl 339 28 Functional functional JJ cord-007714-n3omlvfl 339 29 proteomics proteomic NNS cord-007714-n3omlvfl 339 30 analysis analysis NN cord-007714-n3omlvfl 339 31 of of IN cord-007714-n3omlvfl 339 32 human human JJ cord-007714-n3omlvfl 339 33 nucleolus nucleolus NN cord-007714-n3omlvfl 340 1 The the DT cord-007714-n3omlvfl 340 2 path path NN cord-007714-n3omlvfl 340 3 from from IN cord-007714-n3omlvfl 340 4 nucleolar nucleolar JJ cord-007714-n3omlvfl 340 5 90S 90s CD cord-007714-n3omlvfl 340 6 to to IN cord-007714-n3omlvfl 340 7 cytoplasmic cytoplasmic JJ cord-007714-n3omlvfl 340 8 40S 40s CD cord-007714-n3omlvfl 340 9 pre pre JJ cord-007714-n3omlvfl 340 10 - - JJ cord-007714-n3omlvfl 340 11 ribosomes ribosomes JJ cord-007714-n3omlvfl 340 12 mRNA mrna NN cord-007714-n3omlvfl 340 13 transport transport NN cord-007714-n3omlvfl 340 14 in in IN cord-007714-n3omlvfl 340 15 yeast yeast NN cord-007714-n3omlvfl 340 16 : : : cord-007714-n3omlvfl 340 17 time time NN cord-007714-n3omlvfl 340 18 to to TO cord-007714-n3omlvfl 340 19 reinvestigate reinvestigate VB cord-007714-n3omlvfl 340 20 the the DT cord-007714-n3omlvfl 340 21 functions function NNS cord-007714-n3omlvfl 340 22 of of IN cord-007714-n3omlvfl 340 23 the the DT cord-007714-n3omlvfl 340 24 nucleolus nucleolus NN cord-007714-n3omlvfl 340 25 Plant Plant NNP cord-007714-n3omlvfl 340 26 nuclear nuclear JJ cord-007714-n3omlvfl 340 27 bodies body NNS cord-007714-n3omlvfl 340 28 The the DT cord-007714-n3omlvfl 340 29 nucleolus nucleolus NN cord-007714-n3omlvfl 340 30 Localization localization NN cord-007714-n3omlvfl 340 31 and and CC cord-007714-n3omlvfl 340 32 processing processing NN cord-007714-n3omlvfl 340 33 from from IN cord-007714-n3omlvfl 340 34 a a DT cord-007714-n3omlvfl 340 35 polycistronic polycistronic JJ cord-007714-n3omlvfl 340 36 precursor precursor NN cord-007714-n3omlvfl 340 37 of of IN cord-007714-n3omlvfl 340 38 novel novel NN cord-007714-n3omlvfl 340 39 snoRNAs snoRNAs NNP cord-007714-n3omlvfl 340 40 in in IN cord-007714-n3omlvfl 340 41 maize maize NN cord-007714-n3omlvfl 340 42 Newly newly RB cord-007714-n3omlvfl 340 43 assembled assemble VBN cord-007714-n3omlvfl 340 44 snRNPs snRNPs NNP cord-007714-n3omlvfl 340 45 associate associate NN cord-007714-n3omlvfl 340 46 with with IN cord-007714-n3omlvfl 340 47 coiled coiled JJ cord-007714-n3omlvfl 340 48 bodies body NNS cord-007714-n3omlvfl 340 49 before before IN cord-007714-n3omlvfl 340 50 speckles speckle NNS cord-007714-n3omlvfl 340 51 , , , cord-007714-n3omlvfl 340 52 suggesting suggest VBG cord-007714-n3omlvfl 340 53 a a DT cord-007714-n3omlvfl 340 54 nuclear nuclear JJ cord-007714-n3omlvfl 340 55 snRNP snrnp NN cord-007714-n3omlvfl 340 56 maturation maturation NN cord-007714-n3omlvfl 340 57 pathway pathway NN cord-007714-n3omlvfl 340 58 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 340 59 primary primary JJ cord-007714-n3omlvfl 340 60 microRNA microRNA NNP cord-007714-n3omlvfl 340 61 processing processing NN cord-007714-n3omlvfl 340 62 proteins protein NNS cord-007714-n3omlvfl 340 63 HYL1 HYL1 NNP cord-007714-n3omlvfl 340 64 and and CC cord-007714-n3omlvfl 340 65 DCL1 DCL1 NNP cord-007714-n3omlvfl 340 66 define define VB cord-007714-n3omlvfl 340 67 a a DT cord-007714-n3omlvfl 340 68 nuclear nuclear JJ cord-007714-n3omlvfl 340 69 body body NN cord-007714-n3omlvfl 340 70 distinct distinct JJ cord-007714-n3omlvfl 340 71 from from IN cord-007714-n3omlvfl 340 72 the the DT cord-007714-n3omlvfl 340 73 Cajal Cajal NNP cord-007714-n3omlvfl 340 74 body body NN cord-007714-n3omlvfl 341 1 The the DT cord-007714-n3omlvfl 341 2 nuclear nuclear JJ cord-007714-n3omlvfl 341 3 tRNA trna NN cord-007714-n3omlvfl 341 4 aminoacylation aminoacylation NN cord-007714-n3omlvfl 341 5 - - HYPH cord-007714-n3omlvfl 341 6 dependent dependent JJ cord-007714-n3omlvfl 341 7 pathway pathway NN cord-007714-n3omlvfl 341 8 may may MD cord-007714-n3omlvfl 341 9 be be VB cord-007714-n3omlvfl 341 10 the the DT cord-007714-n3omlvfl 341 11 principal principal JJ cord-007714-n3omlvfl 341 12 route route NN cord-007714-n3omlvfl 341 13 used use VBN cord-007714-n3omlvfl 341 14 to to TO cord-007714-n3omlvfl 341 15 export export VB cord-007714-n3omlvfl 341 16 tRNA trna NN cord-007714-n3omlvfl 341 17 from from IN cord-007714-n3omlvfl 341 18 the the DT cord-007714-n3omlvfl 341 19 nucleus nucleus NN cord-007714-n3omlvfl 341 20 in in IN cord-007714-n3omlvfl 341 21 Saccharomyces Saccharomyces NNP cord-007714-n3omlvfl 341 22 cerevisiae cerevisiae NNS cord-007714-n3omlvfl 342 1 The the DT cord-007714-n3omlvfl 342 2 interplay interplay NN cord-007714-n3omlvfl 342 3 of of IN cord-007714-n3omlvfl 342 4 nuclear nuclear JJ cord-007714-n3omlvfl 342 5 mRNP mrnp NN cord-007714-n3omlvfl 342 6 assembly assembly NN cord-007714-n3omlvfl 342 7 , , , cord-007714-n3omlvfl 342 8 mRNA mrna NN cord-007714-n3omlvfl 342 9 surveillance surveillance NN cord-007714-n3omlvfl 342 10 and and CC cord-007714-n3omlvfl 342 11 export export NN cord-007714-n3omlvfl 343 1 The the DT cord-007714-n3omlvfl 343 2 ever ever RB cord-007714-n3omlvfl 343 3 - - HYPH cord-007714-n3omlvfl 343 4 increasing increase VBG cord-007714-n3omlvfl 343 5 complexities complexity NNS cord-007714-n3omlvfl 343 6 of of IN cord-007714-n3omlvfl 343 7 the the DT cord-007714-n3omlvfl 343 8 exon exon NN cord-007714-n3omlvfl 343 9 junction junction NN cord-007714-n3omlvfl 343 10 complex complex JJ cord-007714-n3omlvfl 343 11 Nucleolar Nucleolar NNP cord-007714-n3omlvfl 343 12 accumulation accumulation NN cord-007714-n3omlvfl 343 13 of of IN cord-007714-n3omlvfl 343 14 poly(A poly(A NNP cord-007714-n3omlvfl 343 15 ) ) -RRB- cord-007714-n3omlvfl 343 16 + + CC cord-007714-n3omlvfl 343 17 RNA RNA NNP cord-007714-n3omlvfl 343 18 in in IN cord-007714-n3omlvfl 343 19 heat heat NN cord-007714-n3omlvfl 343 20 - - HYPH cord-007714-n3omlvfl 343 21 shocked shock VBN cord-007714-n3omlvfl 343 22 yeast yeast NN cord-007714-n3omlvfl 343 23 cells cell NNS cord-007714-n3omlvfl 343 24 : : : cord-007714-n3omlvfl 343 25 implication implication NN cord-007714-n3omlvfl 343 26 of of IN cord-007714-n3omlvfl 343 27 nucleolar nucleolar JJ cord-007714-n3omlvfl 343 28 involvement involvement NN cord-007714-n3omlvfl 343 29 in in IN cord-007714-n3omlvfl 343 30 mRNA mRNA NNP cord-007714-n3omlvfl 343 31 transport transport NN cord-007714-n3omlvfl 344 1 My -PRON- PRP$ cord-007714-n3omlvfl 344 2 favorite favorite JJ cord-007714-n3omlvfl 344 3 organelle organelle NN cord-007714-n3omlvfl 344 4 : : : cord-007714-n3omlvfl 345 1 The the DT cord-007714-n3omlvfl 345 2 ribosome ribosome NN cord-007714-n3omlvfl 345 3 : : : cord-007714-n3omlvfl 345 4 lifting lift VBG cord-007714-n3omlvfl 345 5 the the DT cord-007714-n3omlvfl 345 6 veil veil NN cord-007714-n3omlvfl 345 7 from from IN cord-007714-n3omlvfl 345 8 a a DT cord-007714-n3omlvfl 345 9 fascinating fascinating JJ cord-007714-n3omlvfl 345 10 organelle organelle NN cord-007714-n3omlvfl 345 11 Insights insight NNS cord-007714-n3omlvfl 345 12 into into IN cord-007714-n3omlvfl 345 13 nuclear nuclear JJ cord-007714-n3omlvfl 345 14 organisation organisation NN cord-007714-n3omlvfl 345 15 in in IN cord-007714-n3omlvfl 345 16 plants plant NNS cord-007714-n3omlvfl 345 17 as as IN cord-007714-n3omlvfl 345 18 revealed reveal VBN cord-007714-n3omlvfl 345 19 by by IN cord-007714-n3omlvfl 345 20 the the DT cord-007714-n3omlvfl 345 21 dynamic dynamic JJ cord-007714-n3omlvfl 345 22 distribution distribution NN cord-007714-n3omlvfl 345 23 of of IN cord-007714-n3omlvfl 345 24 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 345 25 SR SR NNP cord-007714-n3omlvfl 345 26 splicing splicing NN cord-007714-n3omlvfl 345 27 factors factor NNS cord-007714-n3omlvfl 345 28 Relocalisation Relocalisation NNP cord-007714-n3omlvfl 345 29 of of IN cord-007714-n3omlvfl 345 30 nuclear nuclear JJ cord-007714-n3omlvfl 345 31 ALY ALY NNP cord-007714-n3omlvfl 345 32 proteins protein NNS cord-007714-n3omlvfl 345 33 to to IN cord-007714-n3omlvfl 345 34 the the DT cord-007714-n3omlvfl 345 35 cytoplasm cytoplasm NN cord-007714-n3omlvfl 345 36 by by IN cord-007714-n3omlvfl 345 37 the the DT cord-007714-n3omlvfl 345 38 Tomato Tomato NNP cord-007714-n3omlvfl 345 39 Bushy Bushy NNP cord-007714-n3omlvfl 345 40 Stunt Stunt NNP cord-007714-n3omlvfl 345 41 Virus Virus NNP cord-007714-n3omlvfl 345 42 p19 p19 NN cord-007714-n3omlvfl 345 43 pathogenicity pathogenicity NN cord-007714-n3omlvfl 345 44 protein protein NN cord-007714-n3omlvfl 345 45 NMD NMD NNP cord-007714-n3omlvfl 345 46 in in IN cord-007714-n3omlvfl 345 47 plants plant NNS cord-007714-n3omlvfl 345 48 . . . cord-007714-n3omlvfl 346 1 NMD NMD NNP cord-007714-n3omlvfl 346 2 in in IN cord-007714-n3omlvfl 346 3 plants plant NNS cord-007714-n3omlvfl 346 4 Ribosome Ribosome NNP cord-007714-n3omlvfl 346 5 synthesis synthesis NN cord-007714-n3omlvfl 346 6 in in IN cord-007714-n3omlvfl 346 7 Saccharomyces saccharomyce NNS cord-007714-n3omlvfl 346 8 cerevisiae cerevisiae NNS cord-007714-n3omlvfl 346 9 Subnuclear Subnuclear NNP cord-007714-n3omlvfl 346 10 shuttling shuttle VBG cord-007714-n3omlvfl 346 11 of of IN cord-007714-n3omlvfl 346 12 human human JJ cord-007714-n3omlvfl 346 13 telomerase telomerase NN cord-007714-n3omlvfl 346 14 induced induce VBN cord-007714-n3omlvfl 346 15 by by IN cord-007714-n3omlvfl 346 16 transformation transformation NN cord-007714-n3omlvfl 346 17 and and CC cord-007714-n3omlvfl 346 18 DNA dna NN cord-007714-n3omlvfl 346 19 damage damage NN cord-007714-n3omlvfl 346 20 Signal signal NN cord-007714-n3omlvfl 346 21 sequence sequence NN cord-007714-n3omlvfl 346 22 recognition recognition NN cord-007714-n3omlvfl 346 23 and and CC cord-007714-n3omlvfl 346 24 protein protein NN cord-007714-n3omlvfl 346 25 targeting target VBG cord-007714-n3omlvfl 346 26 to to IN cord-007714-n3omlvfl 346 27 the the DT cord-007714-n3omlvfl 346 28 endoplasmic endoplasmic NN cord-007714-n3omlvfl 346 29 reticulum reticulum NN cord-007714-n3omlvfl 346 30 membrane membrane NN cord-007714-n3omlvfl 347 1 The the DT cord-007714-n3omlvfl 347 2 prototype prototype NN cord-007714-n3omlvfl 347 3 gamma-2 gamma-2 NN cord-007714-n3omlvfl 347 4 herpesvirus herpesvirus NN cord-007714-n3omlvfl 347 5 nucleocytoplasmic nucleocytoplasmic NNP cord-007714-n3omlvfl 347 6 shuttling shuttle VBG cord-007714-n3omlvfl 347 7 protein protein NN cord-007714-n3omlvfl 347 8 , , , cord-007714-n3omlvfl 347 9 ORF ORF NNP cord-007714-n3omlvfl 347 10 57 57 CD cord-007714-n3omlvfl 347 11 , , , cord-007714-n3omlvfl 347 12 transports transport VBZ cord-007714-n3omlvfl 347 13 viral viral JJ cord-007714-n3omlvfl 347 14 RNA RNA NNP cord-007714-n3omlvfl 347 15 through through IN cord-007714-n3omlvfl 347 16 the the DT cord-007714-n3omlvfl 347 17 cellular cellular JJ cord-007714-n3omlvfl 347 18 mRNA mRNA NNP cord-007714-n3omlvfl 347 19 export export NN cord-007714-n3omlvfl 347 20 pathway pathway NN cord-007714-n3omlvfl 347 21 Light light NN cord-007714-n3omlvfl 347 22 - - HYPH cord-007714-n3omlvfl 347 23 dependent dependent JJ cord-007714-n3omlvfl 347 24 translocation translocation NN cord-007714-n3omlvfl 347 25 of of IN cord-007714-n3omlvfl 347 26 a a DT cord-007714-n3omlvfl 347 27 phytochrome phytochrome NN cord-007714-n3omlvfl 347 28 B B NNP cord-007714-n3omlvfl 347 29 - - HYPH cord-007714-n3omlvfl 347 30 GFP gfp NN cord-007714-n3omlvfl 347 31 fusion fusion NN cord-007714-n3omlvfl 347 32 protein protein NN cord-007714-n3omlvfl 347 33 to to IN cord-007714-n3omlvfl 347 34 the the DT cord-007714-n3omlvfl 347 35 nucleus nucleus NN cord-007714-n3omlvfl 347 36 in in IN cord-007714-n3omlvfl 347 37 transgenic transgenic JJ cord-007714-n3omlvfl 347 38 Arabidopsis Arabidopsis NNP cord-007714-n3omlvfl 347 39 Internal internal JJ cord-007714-n3omlvfl 347 40 modification modification NN cord-007714-n3omlvfl 347 41 of of IN cord-007714-n3omlvfl 347 42 U2 U2 NNP cord-007714-n3omlvfl 347 43 small small JJ cord-007714-n3omlvfl 347 44 nuclear nuclear NN cord-007714-n3omlvfl 347 45 ( ( -LRB- cord-007714-n3omlvfl 347 46 sn)RNA sn)rna NN cord-007714-n3omlvfl 347 47 occurs occur VBZ cord-007714-n3omlvfl 347 48 in in IN cord-007714-n3omlvfl 347 49 nucleoli nucleoli NN cord-007714-n3omlvfl 347 50 of of IN cord-007714-n3omlvfl 347 51 Xenopus Xenopus NNP cord-007714-n3omlvfl 347 52 oocytes oocyte NNS cord-007714-n3omlvfl 348 1 Telomerase Telomerase NNP cord-007714-n3omlvfl 348 2 RNA RNA NNP cord-007714-n3omlvfl 348 3 accumulates accumulate VBZ cord-007714-n3omlvfl 348 4 in in IN cord-007714-n3omlvfl 348 5 Cajal Cajal NNP cord-007714-n3omlvfl 348 6 bodies body NNS cord-007714-n3omlvfl 348 7 in in IN cord-007714-n3omlvfl 348 8 human human JJ cord-007714-n3omlvfl 348 9 cancer cancer NN cord-007714-n3omlvfl 348 10 cells cell NNS