id	sid	tid	token	lemma	pos
cord-000238-om92cx5q	1	1	key	key	JJ
cord-000238-om92cx5q	2	1	:	:	:
cord-000238-om92cx5q	2	2	cord-000238-om92cx5q	cord-000238-om92cx5q	JJ
cord-000238-om92cx5q	2	3	authors	author	NNS
cord-000238-om92cx5q	2	4	:	:	:
cord-000238-om92cx5q	2	5	Ogbunugafor	Ogbunugafor	NNP
cord-000238-om92cx5q	2	6	,	,	,
cord-000238-om92cx5q	2	7	C.	C.	NNP
cord-000238-om92cx5q	2	8	Brandon	Brandon	NNP
cord-000238-om92cx5q	2	9	;	;	:
cord-000238-om92cx5q	2	10	Pease	Pease	NNP
cord-000238-om92cx5q	2	11	,	,	,
cord-000238-om92cx5q	2	12	James	James	NNP
cord-000238-om92cx5q	2	13	B.	B.	NNP
cord-000238-om92cx5q	2	14	;	;	:
cord-000238-om92cx5q	2	15	Turner	Turner	NNP
cord-000238-om92cx5q	2	16	,	,	,
cord-000238-om92cx5q	2	17	Paul	Paul	NNP
cord-000238-om92cx5q	2	18	E.	E.	NNP
cord-000238-om92cx5q	2	19	title	title	NN
cord-000238-om92cx5q	2	20	:	:	:
cord-000238-om92cx5q	3	1	On	on	IN
cord-000238-om92cx5q	3	2	the	the	DT
cord-000238-om92cx5q	3	3	possible	possible	JJ
cord-000238-om92cx5q	3	4	role	role	NN
cord-000238-om92cx5q	3	5	of	of	IN
cord-000238-om92cx5q	3	6	robustness	robustness	NN
cord-000238-om92cx5q	3	7	in	in	IN
cord-000238-om92cx5q	3	8	the	the	DT
cord-000238-om92cx5q	3	9	evolution	evolution	NN
cord-000238-om92cx5q	3	10	of	of	IN
cord-000238-om92cx5q	3	11	infectious	infectious	JJ
cord-000238-om92cx5q	3	12	diseases	disease	NNS
cord-000238-om92cx5q	3	13	date	date	NN
cord-000238-om92cx5q	3	14	:	:	:
cord-000238-om92cx5q	3	15	2010	2010	CD
cord-000238-om92cx5q	3	16	-	-	SYM
cord-000238-om92cx5q	3	17	06	06	CD
cord-000238-om92cx5q	3	18	-	-	SYM
cord-000238-om92cx5q	3	19	30	30	CD
cord-000238-om92cx5q	3	20	journal	journal	NN
cord-000238-om92cx5q	3	21	:	:	:
cord-000238-om92cx5q	4	1	Chaos	chaos	NN
cord-000238-om92cx5q	4	2	DOI	doi	NN
cord-000238-om92cx5q	4	3	:	:	:
cord-000238-om92cx5q	5	1	10.1063/1.3455189	10.1063/1.3455189	CD
cord-000238-om92cx5q	5	2	sha	sha	NNP
cord-000238-om92cx5q	5	3	:	:	:
cord-000238-om92cx5q	5	4	a864ea529dd03034ad7bf347e1dee420a36ae8d2	a864ea529dd03034ad7bf347e1dee420a36ae8d2	CD
cord-000238-om92cx5q	5	5	doc_id	doc_id	CD
cord-000238-om92cx5q	5	6	:	:	:
cord-000238-om92cx5q	5	7	238	238	CD
cord-000238-om92cx5q	5	8	cord_uid	cord_uid	NNS
cord-000238-om92cx5q	5	9	:	:	:
cord-000238-om92cx5q	6	1	om92cx5q	om92cx5q	NNP
cord-000238-om92cx5q	6	2	Robustness	Robustness	NNP
cord-000238-om92cx5q	6	3	describes	describe	VBZ
cord-000238-om92cx5q	6	4	the	the	DT
cord-000238-om92cx5q	6	5	capacity	capacity	NN
cord-000238-om92cx5q	6	6	for	for	IN
cord-000238-om92cx5q	6	7	a	a	DT
cord-000238-om92cx5q	6	8	biological	biological	JJ
cord-000238-om92cx5q	6	9	system	system	NN
cord-000238-om92cx5q	6	10	to	to	TO
cord-000238-om92cx5q	6	11	remain	remain	VB
cord-000238-om92cx5q	6	12	canalized	canalize	VBN
cord-000238-om92cx5q	6	13	despite	despite	IN
cord-000238-om92cx5q	6	14	perturbation	perturbation	NN
cord-000238-om92cx5q	6	15	.	.	.
cord-000238-om92cx5q	7	1	Genetic	genetic	JJ
cord-000238-om92cx5q	7	2	robustness	robustness	NN
cord-000238-om92cx5q	7	3	affords	afford	VBZ
cord-000238-om92cx5q	7	4	maintenance	maintenance	NN
cord-000238-om92cx5q	7	5	of	of	IN
cord-000238-om92cx5q	7	6	phenotype	phenotype	NN
cord-000238-om92cx5q	7	7	despite	despite	IN
cord-000238-om92cx5q	7	8	mutational	mutational	JJ
cord-000238-om92cx5q	7	9	input	input	NN
cord-000238-om92cx5q	7	10	,	,	,
cord-000238-om92cx5q	7	11	necessarily	necessarily	RB
cord-000238-om92cx5q	7	12	involving	involve	VBG
cord-000238-om92cx5q	7	13	the	the	DT
cord-000238-om92cx5q	7	14	role	role	NN
cord-000238-om92cx5q	7	15	of	of	IN
cord-000238-om92cx5q	7	16	epistasis	epistasis	NN
cord-000238-om92cx5q	7	17	.	.	.
cord-000238-om92cx5q	8	1	Environmental	environmental	JJ
cord-000238-om92cx5q	8	2	robustness	robustness	NN
cord-000238-om92cx5q	8	3	is	be	VBZ
cord-000238-om92cx5q	8	4	phenotypic	phenotypic	JJ
cord-000238-om92cx5q	8	5	constancy	constancy	NN
cord-000238-om92cx5q	8	6	in	in	IN
cord-000238-om92cx5q	8	7	the	the	DT
cord-000238-om92cx5q	8	8	face	face	NN
cord-000238-om92cx5q	8	9	of	of	IN
cord-000238-om92cx5q	8	10	environmental	environmental	JJ
cord-000238-om92cx5q	8	11	variation	variation	NN
cord-000238-om92cx5q	8	12	,	,	,
cord-000238-om92cx5q	8	13	where	where	WRB
cord-000238-om92cx5q	8	14	epistasis	epistasis	NN
cord-000238-om92cx5q	8	15	may	may	MD
cord-000238-om92cx5q	8	16	be	be	VB
cord-000238-om92cx5q	8	17	uninvolved	uninvolved	JJ
cord-000238-om92cx5q	8	18	.	.	.
cord-000238-om92cx5q	9	1	Here	here	RB
cord-000238-om92cx5q	9	2	we	-PRON-	PRP
cord-000238-om92cx5q	9	3	discuss	discuss	VBP
cord-000238-om92cx5q	9	4	genetic	genetic	JJ
cord-000238-om92cx5q	9	5	and	and	CC
cord-000238-om92cx5q	9	6	environmental	environmental	JJ
cord-000238-om92cx5q	9	7	robustness	robustness	NN
cord-000238-om92cx5q	9	8	,	,	,
cord-000238-om92cx5q	9	9	from	from	IN
cord-000238-om92cx5q	9	10	the	the	DT
cord-000238-om92cx5q	9	11	standpoint	standpoint	NN
cord-000238-om92cx5q	9	12	of	of	IN
cord-000238-om92cx5q	9	13	infectious	infectious	JJ
cord-000238-om92cx5q	9	14	disease	disease	NN
cord-000238-om92cx5q	9	15	evolution	evolution	NN
cord-000238-om92cx5q	9	16	,	,	,
cord-000238-om92cx5q	9	17	and	and	CC
cord-000238-om92cx5q	9	18	suggest	suggest	VBP
cord-000238-om92cx5q	9	19	that	that	IN
cord-000238-om92cx5q	9	20	robustness	robustness	NN
cord-000238-om92cx5q	9	21	may	may	MD
cord-000238-om92cx5q	9	22	be	be	VB
cord-000238-om92cx5q	9	23	a	a	DT
cord-000238-om92cx5q	9	24	unifying	unifying	JJ
cord-000238-om92cx5q	9	25	principle	principle	NN
cord-000238-om92cx5q	9	26	for	for	IN
cord-000238-om92cx5q	9	27	understanding	understand	VBG
cord-000238-om92cx5q	9	28	how	how	WRB
cord-000238-om92cx5q	9	29	different	different	JJ
cord-000238-om92cx5q	9	30	disease	disease	NN
cord-000238-om92cx5q	9	31	agents	agent	NNS
cord-000238-om92cx5q	9	32	evolve	evolve	VBP
cord-000238-om92cx5q	9	33	.	.	.
cord-000238-om92cx5q	10	1	We	-PRON-	PRP
cord-000238-om92cx5q	10	2	focus	focus	VBP
cord-000238-om92cx5q	10	3	especially	especially	RB
cord-000238-om92cx5q	10	4	on	on	IN
cord-000238-om92cx5q	10	5	viruses	virus	NNS
cord-000238-om92cx5q	10	6	with	with	IN
cord-000238-om92cx5q	10	7	RNA	RNA	NNP
cord-000238-om92cx5q	10	8	genomes	genome	NNS
cord-000238-om92cx5q	10	9	due	due	JJ
cord-000238-om92cx5q	10	10	to	to	IN
cord-000238-om92cx5q	10	11	their	-PRON-	PRP$
cord-000238-om92cx5q	10	12	importance	importance	NN
cord-000238-om92cx5q	10	13	in	in	IN
cord-000238-om92cx5q	10	14	the	the	DT
cord-000238-om92cx5q	10	15	evolution	evolution	NN
cord-000238-om92cx5q	10	16	of	of	IN
cord-000238-om92cx5q	10	17	emerging	emerge	VBG
cord-000238-om92cx5q	10	18	diseases	disease	NNS
cord-000238-om92cx5q	10	19	and	and	CC
cord-000238-om92cx5q	10	20	as	as	IN
cord-000238-om92cx5q	10	21	model	model	NN
cord-000238-om92cx5q	10	22	systems	system	NNS
cord-000238-om92cx5q	10	23	to	to	TO
cord-000238-om92cx5q	10	24	test	test	VB
cord-000238-om92cx5q	10	25	robustness	robustness	NN
cord-000238-om92cx5q	10	26	theory	theory	NN
cord-000238-om92cx5q	10	27	.	.	.
cord-000238-om92cx5q	11	1	We	-PRON-	PRP
cord-000238-om92cx5q	11	2	present	present	VBP
cord-000238-om92cx5q	11	3	new	new	JJ
cord-000238-om92cx5q	11	4	data	datum	NNS
cord-000238-om92cx5q	11	5	on	on	IN
cord-000238-om92cx5q	11	6	adaptive	adaptive	JJ
cord-000238-om92cx5q	11	7	constraints	constraint	NNS
cord-000238-om92cx5q	11	8	for	for	IN
cord-000238-om92cx5q	11	9	a	a	DT
cord-000238-om92cx5q	11	10	model	model	NN
cord-000238-om92cx5q	11	11	RNA	RNA	NNP
cord-000238-om92cx5q	11	12	virus	virus	NN
cord-000238-om92cx5q	11	13	challenged	challenge	VBD
cord-000238-om92cx5q	11	14	to	to	TO
cord-000238-om92cx5q	11	15	evolve	evolve	VB
cord-000238-om92cx5q	11	16	in	in	IN
cord-000238-om92cx5q	11	17	response	response	NN
cord-000238-om92cx5q	11	18	to	to	IN
cord-000238-om92cx5q	11	19	UV	uv	NN
cord-000238-om92cx5q	11	20	radiation	radiation	NN
cord-000238-om92cx5q	11	21	.	.	.
cord-000238-om92cx5q	12	1	We	-PRON-	PRP
cord-000238-om92cx5q	12	2	also	also	RB
cord-000238-om92cx5q	12	3	draw	draw	VBP
cord-000238-om92cx5q	12	4	attention	attention	NN
cord-000238-om92cx5q	12	5	to	to	IN
cord-000238-om92cx5q	12	6	other	other	JJ
cord-000238-om92cx5q	12	7	infectious	infectious	JJ
cord-000238-om92cx5q	12	8	disease	disease	NN
cord-000238-om92cx5q	12	9	systems	system	NNS
cord-000238-om92cx5q	12	10	where	where	WRB
cord-000238-om92cx5q	12	11	robustness	robustness	NN
cord-000238-om92cx5q	12	12	theory	theory	NN
cord-000238-om92cx5q	12	13	may	may	MD
cord-000238-om92cx5q	12	14	prove	prove	VB
cord-000238-om92cx5q	12	15	useful	useful	JJ
cord-000238-om92cx5q	12	16	for	for	IN
cord-000238-om92cx5q	12	17	bridging	bridge	VBG
cord-000238-om92cx5q	12	18	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	12	19	biology	biology	NN
cord-000238-om92cx5q	12	20	and	and	CC
cord-000238-om92cx5q	12	21	biomedicine	biomedicine	NN
cord-000238-om92cx5q	12	22	,	,	,
cord-000238-om92cx5q	12	23	especially	especially	RB
cord-000238-om92cx5q	12	24	the	the	DT
cord-000238-om92cx5q	12	25	evolution	evolution	NN
cord-000238-om92cx5q	12	26	of	of	IN
cord-000238-om92cx5q	12	27	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	12	28	resistance	resistance	NN
cord-000238-om92cx5q	12	29	in	in	IN
cord-000238-om92cx5q	12	30	bacteria	bacteria	NNS
cord-000238-om92cx5q	12	31	,	,	,
cord-000238-om92cx5q	12	32	immune	immune	JJ
cord-000238-om92cx5q	12	33	evasion	evasion	NN
cord-000238-om92cx5q	12	34	by	by	IN
cord-000238-om92cx5q	12	35	influenza	influenza	NN
cord-000238-om92cx5q	12	36	,	,	,
cord-000238-om92cx5q	12	37	and	and	CC
cord-000238-om92cx5q	12	38	malaria	malaria	NN
cord-000238-om92cx5q	12	39	parasite	parasite	NN
cord-000238-om92cx5q	12	40	infections	infection	NNS
cord-000238-om92cx5q	12	41	.	.	.
cord-000238-om92cx5q	13	1	In	in	IN
cord-000238-om92cx5q	13	2	biology	biology	NN
cord-000238-om92cx5q	13	3	,	,	,
cord-000238-om92cx5q	13	4	robustness	robustness	NN
cord-000238-om92cx5q	13	5	describes	describe	VBZ
cord-000238-om92cx5q	13	6	the	the	DT
cord-000238-om92cx5q	13	7	relative	relative	JJ
cord-000238-om92cx5q	13	8	capacity	capacity	NN
cord-000238-om92cx5q	13	9	for	for	IN
cord-000238-om92cx5q	13	10	a	a	DT
cord-000238-om92cx5q	13	11	biological	biological	JJ
cord-000238-om92cx5q	13	12	system	system	NN
cord-000238-om92cx5q	13	13	to	to	TO
cord-000238-om92cx5q	13	14	maintain	maintain	VB
cord-000238-om92cx5q	13	15	constancy	constancy	NN
cord-000238-om92cx5q	13	16	of	of	IN
cord-000238-om92cx5q	13	17	phenotype	phenotype	NN
cord-000238-om92cx5q	13	18	͑e.g	͑e.g	,
cord-000238-om92cx5q	13	19	.	.	.
cord-000238-om92cx5q	14	1	,	,	,
cord-000238-om92cx5q	14	2	population	population	NN
cord-000238-om92cx5q	14	3	growth	growth	NN
cord-000238-om92cx5q	14	4	,	,	,
cord-000238-om92cx5q	14	5	individual	individual	JJ
cord-000238-om92cx5q	14	6	development͒	development͒	''
cord-000238-om92cx5q	14	7	,	,	,
cord-000238-om92cx5q	14	8	despite	despite	IN
cord-000238-om92cx5q	14	9	perturbation	perturbation	NN
cord-000238-om92cx5q	14	10	by	by	IN
cord-000238-om92cx5q	14	11	mutation	mutation	NN
cord-000238-om92cx5q	14	12	͑genetic	͑genetic	,
cord-000238-om92cx5q	14	13	robustness͒	robustness͒	NNP
cord-000238-om92cx5q	14	14	or	or	CC
cord-000238-om92cx5q	14	15	by	by	IN
cord-000238-om92cx5q	14	16	environmental	environmental	JJ
cord-000238-om92cx5q	14	17	change	change	NN
cord-000238-om92cx5q	14	18	͑environmental	͑environmental	.
cord-000238-om92cx5q	15	1	robustness͒.	robustness͒.	NNP
cord-000238-om92cx5q	15	2	[	[	-LRB-
cord-000238-om92cx5q	15	3	1	1	CD
cord-000238-om92cx5q	15	4	]	]	-RRB-
cord-000238-om92cx5q	15	5	[	[	-LRB-
cord-000238-om92cx5q	15	6	2	2	CD
cord-000238-om92cx5q	15	7	]	]	-RRB-
cord-000238-om92cx5q	15	8	[	[	-LRB-
cord-000238-om92cx5q	15	9	3	3	CD
cord-000238-om92cx5q	15	10	]	]	-RRB-
cord-000238-om92cx5q	15	11	[	[	-LRB-
cord-000238-om92cx5q	15	12	4	4	CD
cord-000238-om92cx5q	15	13	]	]	-RRB-
cord-000238-om92cx5q	15	14	Epistasis	Epistasis	NNP
cord-000238-om92cx5q	15	15	is	be	VBZ
cord-000238-om92cx5q	15	16	implicit	implicit	JJ
cord-000238-om92cx5q	15	17	in	in	IN
cord-000238-om92cx5q	15	18	genetic	genetic	JJ
cord-000238-om92cx5q	15	19	robustness	robustness	NN
cord-000238-om92cx5q	15	20	;	;	:
cord-000238-om92cx5q	15	21	a	a	DT
cord-000238-om92cx5q	15	22	robust	robust	JJ
cord-000238-om92cx5q	15	23	genome	genome	NN
cord-000238-om92cx5q	15	24	tends	tend	VBZ
cord-000238-om92cx5q	15	25	to	to	TO
cord-000238-om92cx5q	15	26	retain	retain	VB
cord-000238-om92cx5q	15	27	phenotype	phenotype	NN
cord-000238-om92cx5q	15	28	when	when	WRB
cord-000238-om92cx5q	15	29	a	a	DT
cord-000238-om92cx5q	15	30	mutation	mutation	NN
cord-000238-om92cx5q	15	31	is	be	VBZ
cord-000238-om92cx5q	15	32	introduced	introduce	VBN
cord-000238-om92cx5q	15	33	,	,	,
cord-000238-om92cx5q	15	34	whereas	whereas	IN
cord-000238-om92cx5q	15	35	the	the	DT
cord-000238-om92cx5q	15	36	identical	identical	JJ
cord-000238-om92cx5q	15	37	mutation	mutation	NN
cord-000238-om92cx5q	15	38	is	be	VBZ
cord-000238-om92cx5q	15	39	expected	expect	VBN
cord-000238-om92cx5q	15	40	to	to	TO
cord-000238-om92cx5q	15	41	typically	typically	RB
cord-000238-om92cx5q	15	42	alter	alter	VB
cord-000238-om92cx5q	15	43	phenotype	phenotype	NN
cord-000238-om92cx5q	15	44	when	when	WRB
cord-000238-om92cx5q	15	45	placed	place	VBN
cord-000238-om92cx5q	15	46	in	in	IN
cord-000238-om92cx5q	15	47	a	a	DT
cord-000238-om92cx5q	15	48	brittle	brittle	JJ
cord-000238-om92cx5q	15	49	͑nonrobust͒	͑nonrobust͒	NN
cord-000238-om92cx5q	15	50	genetic	genetic	JJ
cord-000238-om92cx5q	15	51	background	background	NN
cord-000238-om92cx5q	15	52	.	.	.
cord-000238-om92cx5q	16	1	Both	both	DT
cord-000238-om92cx5q	16	2	types	type	NNS
cord-000238-om92cx5q	16	3	of	of	IN
cord-000238-om92cx5q	16	4	robustness	robustness	NN
cord-000238-om92cx5q	16	5	are	be	VBP
cord-000238-om92cx5q	16	6	central	central	JJ
cord-000238-om92cx5q	16	7	to	to	IN
cord-000238-om92cx5q	16	8	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	16	9	biology	biology	NN
cord-000238-om92cx5q	16	10	because	because	IN
cord-000238-om92cx5q	16	11	robustness	robustness	NN
cord-000238-om92cx5q	16	12	dictates	dictate	VBZ
cord-000238-om92cx5q	16	13	how	how	WRB
cord-000238-om92cx5q	16	14	organisms	organism	NNS
cord-000238-om92cx5q	16	15	respond	respond	VBP
cord-000238-om92cx5q	16	16	to	to	IN
cord-000238-om92cx5q	16	17	environmental	environmental	JJ
cord-000238-om92cx5q	16	18	challenges	challenge	NNS
cord-000238-om92cx5q	16	19	,	,	,
cord-000238-om92cx5q	16	20	the	the	DT
cord-000238-om92cx5q	16	21	very	very	JJ
cord-000238-om92cx5q	16	22	crux	crux	NN
cord-000238-om92cx5q	16	23	of	of	IN
cord-000238-om92cx5q	16	24	natural	natural	JJ
cord-000238-om92cx5q	16	25	selection	selection	NN
cord-000238-om92cx5q	16	26	.	.	.
cord-000238-om92cx5q	17	1	Advancements	advancement	NNS
cord-000238-om92cx5q	17	2	in	in	IN
cord-000238-om92cx5q	17	3	the	the	DT
cord-000238-om92cx5q	17	4	understanding	understanding	NN
cord-000238-om92cx5q	17	5	of	of	IN
cord-000238-om92cx5q	17	6	robustness	robustness	NN
cord-000238-om92cx5q	17	7	and	and	CC
cord-000238-om92cx5q	17	8	its	-PRON-	PRP$
cord-000238-om92cx5q	17	9	evolution	evolution	NN
cord-000238-om92cx5q	17	10	have	have	VBP
cord-000238-om92cx5q	17	11	often	often	RB
cord-000238-om92cx5q	17	12	arrived	arrive	VBN
cord-000238-om92cx5q	17	13	through	through	IN
cord-000238-om92cx5q	17	14	theoretical	theoretical	JJ
cord-000238-om92cx5q	17	15	studies	study	NNS
cord-000238-om92cx5q	17	16	,	,	,
cord-000238-om92cx5q	17	17	[	[	-LRB-
cord-000238-om92cx5q	17	18	5	5	CD
cord-000238-om92cx5q	17	19	]	]	-RRB-
cord-000238-om92cx5q	17	20	[	[	-LRB-
cord-000238-om92cx5q	17	21	6	6	CD
cord-000238-om92cx5q	17	22	]	]	-RRB-
cord-000238-om92cx5q	17	23	[	[	-LRB-
cord-000238-om92cx5q	17	24	7	7	CD
cord-000238-om92cx5q	17	25	]	]	-RRB-
cord-000238-om92cx5q	18	1	[	[	-LRB-
cord-000238-om92cx5q	18	2	8	8	CD
cord-000238-om92cx5q	18	3	]	]	-RRB-
cord-000238-om92cx5q	19	1	but	but	CC
cord-000238-om92cx5q	19	2	empirical	empirical	JJ
cord-000238-om92cx5q	19	3	studies	study	NNS
cord-000238-om92cx5q	19	4	have	have	VBP
cord-000238-om92cx5q	19	5	made	make	VBN
cord-000238-om92cx5q	19	6	recent	recent	JJ
cord-000238-om92cx5q	19	7	in	in	IN
cord-000238-om92cx5q	19	8	-	-	HYPH
cord-000238-om92cx5q	19	9	roads	road	NNS
cord-000238-om92cx5q	19	10	.	.	.
cord-000238-om92cx5q	20	1	Experiments	experiment	NNS
cord-000238-om92cx5q	20	2	using	use	VBG
cord-000238-om92cx5q	20	3	artificial	artificial	JJ
cord-000238-om92cx5q	20	4	life	life	NN
cord-000238-om92cx5q	20	5	͑"digital	͑"digital	IN
cord-000238-om92cx5q	20	6	organisms	organism	NNS
cord-000238-om92cx5q	20	7	,	,	,
cord-000238-om92cx5q	20	8	"	"	''
cord-000238-om92cx5q	20	9	selfreplicating	selfreplicate	VBG
cord-000238-om92cx5q	20	10	computer	computer	NN
cord-000238-om92cx5q	20	11	programs	program	NNS
cord-000238-om92cx5q	20	12	that	that	WDT
cord-000238-om92cx5q	20	13	can	can	MD
cord-000238-om92cx5q	20	14	evolve͒	evolve͒	VB
cord-000238-om92cx5q	20	15	valuably	valuably	RB
cord-000238-om92cx5q	20	16	demonstrated	demonstrate	VBD
cord-000238-om92cx5q	20	17	that	that	IN
cord-000238-om92cx5q	20	18	elevated	elevated	JJ
cord-000238-om92cx5q	20	19	mutation	mutation	NN
cord-000238-om92cx5q	20	20	rates	rate	NNS
cord-000238-om92cx5q	20	21	can	can	MD
cord-000238-om92cx5q	20	22	select	select	VB
cord-000238-om92cx5q	20	23	for	for	IN
cord-000238-om92cx5q	20	24	evolved	evolved	JJ
cord-000238-om92cx5q	20	25	increases	increase	NNS
cord-000238-om92cx5q	20	26	in	in	IN
cord-000238-om92cx5q	20	27	genetic	genetic	JJ
cord-000238-om92cx5q	20	28	robustness	robustness	NN
cord-000238-om92cx5q	20	29	to	to	TO
cord-000238-om92cx5q	20	30	tolerate	tolerate	VB
cord-000238-om92cx5q	20	31	mutation	mutation	NN
cord-000238-om92cx5q	20	32	,	,	,
cord-000238-om92cx5q	20	33	even	even	RB
cord-000238-om92cx5q	20	34	at	at	IN
cord-000238-om92cx5q	20	35	the	the	DT
cord-000238-om92cx5q	20	36	expense	expense	NN
cord-000238-om92cx5q	20	37	of	of	IN
cord-000238-om92cx5q	20	38	reduced	reduce	VBN
cord-000238-om92cx5q	20	39	reproductive	reproductive	JJ
cord-000238-om92cx5q	20	40	fitness	fitness	NN
cord-000238-om92cx5q	20	41	.	.	.
cord-000238-om92cx5q	21	1	9	9	CD
cord-000238-om92cx5q	22	1	The	the	DT
cord-000238-om92cx5q	22	2	explanation	explanation	NN
cord-000238-om92cx5q	22	3	was	be	VBD
cord-000238-om92cx5q	22	4	that	that	IN
cord-000238-om92cx5q	22	5	high	high	JJ
cord-000238-om92cx5q	22	6	mutation	mutation	NN
cord-000238-om92cx5q	22	7	rates	rate	NNS
cord-000238-om92cx5q	22	8	could	could	MD
cord-000238-om92cx5q	22	9	selectively	selectively	RB
cord-000238-om92cx5q	22	10	favor	favor	VB
cord-000238-om92cx5q	22	11	genetic	genetic	JJ
cord-000238-om92cx5q	22	12	variants	variant	NNS
cord-000238-om92cx5q	22	13	that	that	WDT
cord-000238-om92cx5q	22	14	were	be	VBD
cord-000238-om92cx5q	22	15	not	not	RB
cord-000238-om92cx5q	22	16	necessarily	necessarily	RB
cord-000238-om92cx5q	22	17	productive	productive	JJ
cord-000238-om92cx5q	22	18	and	and	CC
cord-000238-om92cx5q	22	19	resided	reside	VBD
cord-000238-om92cx5q	22	20	on	on	IN
cord-000238-om92cx5q	22	21	flat	flat	JJ
cord-000238-om92cx5q	22	22	regions	region	NNS
cord-000238-om92cx5q	22	23	of	of	IN
cord-000238-om92cx5q	22	24	the	the	DT
cord-000238-om92cx5q	22	25	"	"	``
cord-000238-om92cx5q	22	26	fitness	fitness	NN
cord-000238-om92cx5q	22	27	landscape	landscape	NN
cord-000238-om92cx5q	22	28	;	;	:
cord-000238-om92cx5q	22	29	"	"	``
cord-000238-om92cx5q	22	30	these	these	DT
cord-000238-om92cx5q	22	31	robust	robust	JJ
cord-000238-om92cx5q	22	32	genotypes	genotype	NNS
cord-000238-om92cx5q	22	33	formed	form	VBD
cord-000238-om92cx5q	22	34	an	an	DT
cord-000238-om92cx5q	22	35	epistatic	epistatic	JJ
cord-000238-om92cx5q	22	36	network	network	NN
cord-000238-om92cx5q	22	37	that	that	WDT
cord-000238-om92cx5q	22	38	produced	produce	VBD
cord-000238-om92cx5q	22	39	equally	equally	RB
cord-000238-om92cx5q	22	40	fit	fit	JJ
cord-000238-om92cx5q	22	41	phenotypes	phenotype	NNS
cord-000238-om92cx5q	22	42	despite	despite	IN
cord-000238-om92cx5q	22	43	mutation	mutation	NN
cord-000238-om92cx5q	22	44	-	-	HYPH
cord-000238-om92cx5q	22	45	induced	induce	VBN
cord-000238-om92cx5q	22	46	movement	movement	NN
cord-000238-om92cx5q	22	47	across	across	IN
cord-000238-om92cx5q	22	48	the	the	DT
cord-000238-om92cx5q	22	49	landscape	landscape	NN
cord-000238-om92cx5q	23	1	͑Fig	͑Fig	NNP
cord-000238-om92cx5q	23	2	.	.	.
cord-000238-om92cx5q	24	1	1͒.	1͒.	CD
cord-000238-om92cx5q	24	2	6	6	CD
cord-000238-om92cx5q	24	3	,	,	,
cord-000238-om92cx5q	24	4	8	8	CD
cord-000238-om92cx5q	24	5	,	,	,
cord-000238-om92cx5q	24	6	10	10	CD
cord-000238-om92cx5q	24	7	Other	other	JJ
cord-000238-om92cx5q	24	8	landmark	landmark	NN
cord-000238-om92cx5q	24	9	studies	study	NNS
cord-000238-om92cx5q	24	10	have	have	VBP
cord-000238-om92cx5q	24	11	successfully	successfully	RB
cord-000238-om92cx5q	24	12	examined	examine	VBN
cord-000238-om92cx5q	24	13	robustness	robustness	NN
cord-000238-om92cx5q	24	14	by	by	IN
cord-000238-om92cx5q	24	15	considering	consider	VBG
cord-000238-om92cx5q	24	16	phenotypic	phenotypic	JJ
cord-000238-om92cx5q	24	17	effects	effect	NNS
cord-000238-om92cx5q	24	18	of	of	IN
cord-000238-om92cx5q	24	19	mutations	mutation	NNS
cord-000238-om92cx5q	24	20	underlying	underlie	VBG
cord-000238-om92cx5q	24	21	proteins	protein	NNS
cord-000238-om92cx5q	24	22	using	use	VBG
cord-000238-om92cx5q	24	23	computational	computational	JJ
cord-000238-om92cx5q	24	24	and	and	CC
cord-000238-om92cx5q	24	25	in	in	IN
cord-000238-om92cx5q	24	26	vitro	vitro	FW
cord-000238-om92cx5q	24	27	approaches	approach	NNS
cord-000238-om92cx5q	24	28	.	.	.
cord-000238-om92cx5q	25	1	11	11	CD
cord-000238-om92cx5q	25	2	,	,	,
cord-000238-om92cx5q	25	3	12	12	CD
cord-000238-om92cx5q	25	4	Viruses	virus	NNS
cord-000238-om92cx5q	25	5	with	with	IN
cord-000238-om92cx5q	25	6	RNA	RNA	NNP
cord-000238-om92cx5q	25	7	genomes	genome	NNS
cord-000238-om92cx5q	25	8	are	be	VBP
cord-000238-om92cx5q	25	9	natural	natural	JJ
cord-000238-om92cx5q	25	10	systems	system	NNS
cord-000238-om92cx5q	25	11	that	that	WDT
cord-000238-om92cx5q	25	12	typically	typically	RB
cord-000238-om92cx5q	25	13	experience	experience	VBP
cord-000238-om92cx5q	25	14	high	high	JJ
cord-000238-om92cx5q	25	15	mutation	mutation	NN
cord-000238-om92cx5q	25	16	rates	rate	NNS
cord-000238-om92cx5q	25	17	owing	owe	VBG
cord-000238-om92cx5q	25	18	to	to	IN
cord-000238-om92cx5q	25	19	their	-PRON-	PRP$
cord-000238-om92cx5q	25	20	lack	lack	NN
cord-000238-om92cx5q	25	21	of	of	IN
cord-000238-om92cx5q	25	22	error	error	NN
cord-000238-om92cx5q	25	23	-	-	HYPH
cord-000238-om92cx5q	25	24	repair	repair	NN
cord-000238-om92cx5q	25	25	during	during	IN
cord-000238-om92cx5q	25	26	replication	replication	NN
cord-000238-om92cx5q	25	27	.	.	.
cord-000238-om92cx5q	26	1	Thus	thus	RB
cord-000238-om92cx5q	26	2	,	,	,
cord-000238-om92cx5q	26	3	RNA	RNA	NNP
cord-000238-om92cx5q	26	4	viruses	virus	NNS
cord-000238-om92cx5q	26	5	have	have	VBP
cord-000238-om92cx5q	26	6	proved	prove	VBN
cord-000238-om92cx5q	26	7	to	to	TO
cord-000238-om92cx5q	26	8	be	be	VB
cord-000238-om92cx5q	26	9	useful	useful	JJ
cord-000238-om92cx5q	26	10	and	and	CC
cord-000238-om92cx5q	26	11	tractable	tractable	JJ
cord-000238-om92cx5q	26	12	models	model	NNS
cord-000238-om92cx5q	26	13	for	for	IN
cord-000238-om92cx5q	26	14	studying	study	VBG
cord-000238-om92cx5q	26	15	robustness	robustness	NN
cord-000238-om92cx5q	26	16	evolution	evolution	NN
cord-000238-om92cx5q	26	17	in	in	IN
cord-000238-om92cx5q	26	18	biological	biological	JJ
cord-000238-om92cx5q	26	19	populations	population	NNS
cord-000238-om92cx5q	26	20	.	.	.
cord-000238-om92cx5q	27	1	This	this	DT
cord-000238-om92cx5q	27	2	work	work	NN
cord-000238-om92cx5q	27	3	has	have	VBZ
cord-000238-om92cx5q	27	4	focused	focus	VBN
cord-000238-om92cx5q	27	5	on	on	IN
cord-000238-om92cx5q	27	6	the	the	DT
cord-000238-om92cx5q	27	7	success	success	NN
cord-000238-om92cx5q	27	8	of	of	IN
cord-000238-om92cx5q	27	9	robust	robust	JJ
cord-000238-om92cx5q	27	10	versus	versus	IN
cord-000238-om92cx5q	27	11	nonrobust	nonrobust	NNP
cord-000238-om92cx5q	27	12	RNA	RNA	NNP
cord-000238-om92cx5q	27	13	virus	virus	NN
cord-000238-om92cx5q	27	14	variants	variant	NNS
cord-000238-om92cx5q	27	15	when	when	WRB
cord-000238-om92cx5q	27	16	mutation	mutation	NN
cord-000238-om92cx5q	27	17	rates	rate	NNS
cord-000238-om92cx5q	27	18	are	be	VBP
cord-000238-om92cx5q	27	19	further	further	RB
cord-000238-om92cx5q	27	20	elevated	elevate	VBN
cord-000238-om92cx5q	27	21	through	through	IN
cord-000238-om92cx5q	27	22	exposure	exposure	NN
cord-000238-om92cx5q	27	23	to	to	IN
cord-000238-om92cx5q	27	24	ultraviolet	ultraviolet	NN
cord-000238-om92cx5q	27	25	͑UV͒	͑UV͒	.
cord-000238-om92cx5q	27	26	light	light	NN
cord-000238-om92cx5q	27	27	and	and	CC
cord-000238-om92cx5q	27	28	other	other	JJ
cord-000238-om92cx5q	27	29	mutagens	mutagen	NNS
cord-000238-om92cx5q	27	30	,	,	,
cord-000238-om92cx5q	27	31	13	13	CD
cord-000238-om92cx5q	27	32	and	and	CC
cord-000238-om92cx5q	27	33	on	on	IN
cord-000238-om92cx5q	27	34	evolved	evolved	JJ
cord-000238-om92cx5q	27	35	changes	change	NNS
cord-000238-om92cx5q	27	36	in	in	IN
cord-000238-om92cx5q	27	37	robustness	robustness	NN
cord-000238-om92cx5q	27	38	under	under	IN
cord-000238-om92cx5q	27	39	frequent	frequent	JJ
cord-000238-om92cx5q	27	40	virus	virus	NN
cord-000238-om92cx5q	27	41	coin	coin	NN
cord-000238-om92cx5q	27	42	-	-	HYPH
cord-000238-om92cx5q	27	43	fection	fection	NN
cord-000238-om92cx5q	27	44	,	,	,
cord-000238-om92cx5q	27	45	which	which	WDT
cord-000238-om92cx5q	27	46	allows	allow	VBZ
cord-000238-om92cx5q	27	47	buffering	buffering	NN
cord-000238-om92cx5q	27	48	of	of	IN
cord-000238-om92cx5q	27	49	mutational	mutational	JJ
cord-000238-om92cx5q	27	50	effects	effect	NNS
cord-000238-om92cx5q	27	51	via	via	IN
cord-000238-om92cx5q	27	52	complementation	complementation	NN
cord-000238-om92cx5q	27	53	.	.	.
cord-000238-om92cx5q	28	1	14	14	CD
cord-000238-om92cx5q	29	1	Below	below	IN
cord-000238-om92cx5q	29	2	we	-PRON-	PRP
cord-000238-om92cx5q	29	3	review	review	VBP
cord-000238-om92cx5q	29	4	some	some	DT
cord-000238-om92cx5q	29	5	of	of	IN
cord-000238-om92cx5q	29	6	the	the	DT
cord-000238-om92cx5q	29	7	evidence	evidence	NN
cord-000238-om92cx5q	29	8	from	from	IN
cord-000238-om92cx5q	29	9	these	these	DT
cord-000238-om92cx5q	29	10	studies	study	NNS
cord-000238-om92cx5q	29	11	,	,	,
cord-000238-om92cx5q	29	12	and	and	CC
cord-000238-om92cx5q	29	13	present	present	JJ
cord-000238-om92cx5q	29	14	new	new	JJ
cord-000238-om92cx5q	29	15	findings	finding	NNS
cord-000238-om92cx5q	29	16	from	from	IN
cord-000238-om92cx5q	29	17	an	an	DT
cord-000238-om92cx5q	29	18	increasingly	increasingly	RB
cord-000238-om92cx5q	29	19	popular	popular	JJ
cord-000238-om92cx5q	29	20	model	model	NN
cord-000238-om92cx5q	29	21	system	system	NN
cord-000238-om92cx5q	29	22	for	for	IN
cord-000238-om92cx5q	29	23	examining	examine	VBG
cord-000238-om92cx5q	29	24	evolution	evolution	NN
cord-000238-om92cx5q	29	25	of	of	IN
cord-000238-om92cx5q	29	26	robustness	robustness	NN
cord-000238-om92cx5q	29	27	:	:	:
cord-000238-om92cx5q	29	28	the	the	DT
cord-000238-om92cx5q	29	29	segmented	segmented	JJ
cord-000238-om92cx5q	29	30	RNA	RNA	NNP
cord-000238-om92cx5q	29	31	bacteriophage	bacteriophage	NN
cord-000238-om92cx5q	29	32	6	6	CD
cord-000238-om92cx5q	29	33	.	.	.
cord-000238-om92cx5q	30	1	[	[	-LRB-
cord-000238-om92cx5q	30	2	14	14	CD
cord-000238-om92cx5q	30	3	]	]	-RRB-
cord-000238-om92cx5q	30	4	[	[	-LRB-
cord-000238-om92cx5q	30	5	15	15	CD
cord-000238-om92cx5q	30	6	]	]	-RRB-
cord-000238-om92cx5q	30	7	[	[	-LRB-
cord-000238-om92cx5q	30	8	16	16	CD
cord-000238-om92cx5q	30	9	]	]	-RRB-
cord-000238-om92cx5q	31	1	In	in	IN
cord-000238-om92cx5q	31	2	reviewing	review	VBG
cord-000238-om92cx5q	31	3	these	these	DT
cord-000238-om92cx5q	31	4	results	result	NNS
cord-000238-om92cx5q	31	5	,	,	,
cord-000238-om92cx5q	31	6	we	-PRON-	PRP
cord-000238-om92cx5q	31	7	hope	hope	VBP
cord-000238-om92cx5q	31	8	to	to	TO
cord-000238-om92cx5q	31	9	highlight	highlight	VB
cord-000238-om92cx5q	31	10	the	the	DT
cord-000238-om92cx5q	31	11	importance	importance	NN
cord-000238-om92cx5q	31	12	of	of	IN
cord-000238-om92cx5q	31	13	empirical	empirical	JJ
cord-000238-om92cx5q	31	14	work	work	NN
cord-000238-om92cx5q	31	15	in	in	IN
cord-000238-om92cx5q	31	16	RNA	RNA	NNP
cord-000238-om92cx5q	31	17	viruses	virus	NNS
cord-000238-om92cx5q	31	18	for	for	IN
cord-000238-om92cx5q	31	19	testing	testing	NN
cord-000238-om92cx5q	31	20	theory	theory	NN
cord-000238-om92cx5q	31	21	pertaining	pertain	VBG
cord-000238-om92cx5q	31	22	to	to	IN
cord-000238-om92cx5q	31	23	robustness	robustness	NN
cord-000238-om92cx5q	31	24	,	,	,
cord-000238-om92cx5q	31	25	as	as	RB
cord-000238-om92cx5q	31	26	well	well	RB
cord-000238-om92cx5q	31	27	as	as	IN
cord-000238-om92cx5q	31	28	for	for	IN
cord-000238-om92cx5q	31	29	better	well	JJR
cord-000238-om92cx5q	31	30	understanding	understand	VBG
cord-000238-om92cx5q	31	31	the	the	DT
cord-000238-om92cx5q	31	32	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	31	33	biology	biology	NN
cord-000238-om92cx5q	31	34	and	and	CC
cord-000238-om92cx5q	31	35	evolvability	evolvability	NN
cord-000238-om92cx5q	31	36	of	of	IN
cord-000238-om92cx5q	31	37	infectious	infectious	JJ
cord-000238-om92cx5q	31	38	organisms	organism	NNS
cord-000238-om92cx5q	31	39	in	in	IN
cord-000238-om92cx5q	31	40	general	general	JJ
cord-000238-om92cx5q	31	41	.	.	.
cord-000238-om92cx5q	32	1	Our	-PRON-	PRP$
cord-000238-om92cx5q	32	2	second	second	JJ
cord-000238-om92cx5q	32	3	main	main	JJ
cord-000238-om92cx5q	32	4	goal	goal	NN
cord-000238-om92cx5q	32	5	is	be	VBZ
cord-000238-om92cx5q	32	6	to	to	TO
cord-000238-om92cx5q	32	7	review	review	VB
cord-000238-om92cx5q	32	8	the	the	DT
cord-000238-om92cx5q	32	9	evidence	evidence	NN
cord-000238-om92cx5q	32	10	from	from	IN
cord-000238-om92cx5q	32	11	biomedically	biomedically	RB
cord-000238-om92cx5q	32	12	important	important	JJ
cord-000238-om92cx5q	32	13	infectious	infectious	JJ
cord-000238-om92cx5q	32	14	diseases	disease	NNS
cord-000238-om92cx5q	32	15	of	of	IN
cord-000238-om92cx5q	32	16	humans	human	NNS
cord-000238-om92cx5q	32	17	,	,	,
cord-000238-om92cx5q	32	18	describing	describe	VBG
cord-000238-om92cx5q	32	19	how	how	WRB
cord-000238-om92cx5q	32	20	the	the	DT
cord-000238-om92cx5q	32	21	success	success	NN
cord-000238-om92cx5q	32	22	of	of	IN
cord-000238-om92cx5q	32	23	various	various	JJ
cord-000238-om92cx5q	32	24	disease	disease	NN
cord-000238-om92cx5q	32	25	agents	agent	NNS
cord-000238-om92cx5q	32	26	may	may	MD
cord-000238-om92cx5q	32	27	be	be	VB
cord-000238-om92cx5q	32	28	commonly	commonly	RB
cord-000238-om92cx5q	32	29	considered	consider	VBN
cord-000238-om92cx5q	32	30	in	in	IN
cord-000238-om92cx5q	32	31	light	light	NN
cord-000238-om92cx5q	32	32	of	of	IN
cord-000238-om92cx5q	32	33	their	-PRON-	PRP$
cord-000238-om92cx5q	32	34	genetic	genetic	JJ
cord-000238-om92cx5q	32	35	and/or	and/or	CC
cord-000238-om92cx5q	32	36	environmental	environmental	JJ
cord-000238-om92cx5q	32	37	robustness	robustness	NN
cord-000238-om92cx5q	32	38	.	.	.
cord-000238-om92cx5q	33	1	The	the	DT
cord-000238-om92cx5q	33	2	importance	importance	NN
cord-000238-om92cx5q	33	3	of	of	IN
cord-000238-om92cx5q	33	4	robustness	robustness	NN
cord-000238-om92cx5q	33	5	has	have	VBZ
cord-000238-om92cx5q	33	6	been	be	VBN
cord-000238-om92cx5q	33	7	discussed	discuss	VBN
cord-000238-om92cx5q	33	8	in	in	IN
cord-000238-om92cx5q	33	9	the	the	DT
cord-000238-om92cx5q	33	10	context	context	NN
cord-000238-om92cx5q	33	11	of	of	IN
cord-000238-om92cx5q	33	12	noninfectious	noninfectious	JJ
cord-000238-om92cx5q	33	13	diseases	disease	NNS
cord-000238-om92cx5q	33	14	such	such	JJ
cord-000238-om92cx5q	33	15	as	as	IN
cord-000238-om92cx5q	33	16	cancers	cancer	NNS
cord-000238-om92cx5q	33	17	and	and	CC
cord-000238-om92cx5q	33	18	metabolic	metabolic	JJ
cord-000238-om92cx5q	33	19	syndromes	syndrome	NNS
cord-000238-om92cx5q	33	20	.	.	.
cord-000238-om92cx5q	34	1	17	17	CD
cord-000238-om92cx5q	34	2	,	,	,
cord-000238-om92cx5q	34	3	18	18	CD
cord-000238-om92cx5q	34	4	Here	here	RB
cord-000238-om92cx5q	34	5	we	-PRON-	PRP
cord-000238-om92cx5q	34	6	focus	focus	VBP
cord-000238-om92cx5q	34	7	particularly	particularly	RB
cord-000238-om92cx5q	34	8	on	on	IN
cord-000238-om92cx5q	34	9	infectious	infectious	JJ
cord-000238-om92cx5q	34	10	disease	disease	NN
cord-000238-om92cx5q	34	11	systems	system	NNS
cord-000238-om92cx5q	34	12	:	:	:
cord-000238-om92cx5q	35	1	the	the	DT
cord-000238-om92cx5q	35	2	evolution	evolution	NN
cord-000238-om92cx5q	35	3	of	of	IN
cord-000238-om92cx5q	35	4	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	35	5	resistance	resistance	NN
cord-000238-om92cx5q	35	6	in	in	IN
cord-000238-om92cx5q	35	7	bacteria	bacteria	NNS
cord-000238-om92cx5q	35	8	,	,	,
cord-000238-om92cx5q	35	9	influenza	influenza	NN
cord-000238-om92cx5q	35	10	virus	virus	NN
cord-000238-om92cx5q	35	11	host	host	NN
cord-000238-om92cx5q	35	12	shifts	shift	NNS
cord-000238-om92cx5q	35	13	,	,	,
cord-000238-om92cx5q	35	14	and	and	CC
cord-000238-om92cx5q	35	15	malaria	malaria	NN
cord-000238-om92cx5q	35	16	parasite	parasite	NN
cord-000238-om92cx5q	35	17	invasion	invasion	NN
cord-000238-om92cx5q	35	18	.	.	.
cord-000238-om92cx5q	36	1	A	a	DT
cord-000238-om92cx5q	36	2	review	review	NN
cord-000238-om92cx5q	36	3	of	of	IN
cord-000238-om92cx5q	36	4	these	these	DT
cord-000238-om92cx5q	36	5	studies	study	NNS
cord-000238-om92cx5q	36	6	seeks	seek	VBZ
cord-000238-om92cx5q	36	7	to	to	TO
cord-000238-om92cx5q	36	8	further	further	RB
cord-000238-om92cx5q	36	9	demonstrate	demonstrate	VB
cord-000238-om92cx5q	36	10	the	the	DT
cord-000238-om92cx5q	36	11	broad	broad	JJ
cord-000238-om92cx5q	36	12	importance	importance	NN
cord-000238-om92cx5q	36	13	of	of	IN
cord-000238-om92cx5q	36	14	robustness	robustness	NN
cord-000238-om92cx5q	36	15	to	to	IN
cord-000238-om92cx5q	36	16	theories	theory	NNS
cord-000238-om92cx5q	36	17	of	of	IN
cord-000238-om92cx5q	36	18	biological	biological	JJ
cord-000238-om92cx5q	36	19	systems	system	NNS
cord-000238-om92cx5q	36	20	,	,	,
cord-000238-om92cx5q	36	21	and	and	CC
cord-000238-om92cx5q	36	22	the	the	DT
cord-000238-om92cx5q	36	23	evolution	evolution	NN
cord-000238-om92cx5q	36	24	of	of	IN
cord-000238-om92cx5q	36	25	infectious	infectious	JJ
cord-000238-om92cx5q	36	26	disease	disease	NN
cord-000238-om92cx5q	36	27	.	.	.
cord-000238-om92cx5q	37	1	If	if	IN
cord-000238-om92cx5q	37	2	a	a	DT
cord-000238-om92cx5q	37	3	population	population	NN
cord-000238-om92cx5q	37	4	is	be	VBZ
cord-000238-om92cx5q	37	5	well	well	RB
cord-000238-om92cx5q	37	6	-	-	HYPH
cord-000238-om92cx5q	37	7	adapted	adapt	VBN
cord-000238-om92cx5q	37	8	to	to	IN
cord-000238-om92cx5q	37	9	its	-PRON-	PRP$
cord-000238-om92cx5q	37	10	environment	environment	NN
cord-000238-om92cx5q	37	11	,	,	,
cord-000238-om92cx5q	37	12	almost	almost	RB
cord-000238-om92cx5q	37	13	all	all	DT
cord-000238-om92cx5q	37	14	mutations	mutation	NNS
cord-000238-om92cx5q	37	15	should	should	MD
cord-000238-om92cx5q	37	16	lead	lead	VB
cord-000238-om92cx5q	37	17	to	to	IN
cord-000238-om92cx5q	37	18	deviations	deviation	NNS
cord-000238-om92cx5q	37	19	from	from	IN
cord-000238-om92cx5q	37	20	optimal	optimal	JJ
cord-000238-om92cx5q	37	21	performance	performance	NN
cord-000238-om92cx5q	37	22	in	in	IN
cord-000238-om92cx5q	37	23	the	the	DT
cord-000238-om92cx5q	37	24	selective	selective	JJ
cord-000238-om92cx5q	37	25	habitat	habitat	NN
cord-000238-om92cx5q	37	26	.	.	.
cord-000238-om92cx5q	38	1	Therefore	therefore	RB
cord-000238-om92cx5q	38	2	,	,	,
cord-000238-om92cx5q	38	3	populations	population	NNS
cord-000238-om92cx5q	38	4	at	at	IN
cord-000238-om92cx5q	38	5	equilibrium	equilibrium	NN
cord-000238-om92cx5q	38	6	are	be	VBP
cord-000238-om92cx5q	38	7	expected	expect	VBN
cord-000238-om92cx5q	38	8	to	to	TO
cord-000238-om92cx5q	38	9	experience	experience	VB
cord-000238-om92cx5q	38	10	selection	selection	NN
cord-000238-om92cx5q	38	11	for	for	IN
cord-000238-om92cx5q	38	12	genetic	genetic	JJ
cord-000238-om92cx5q	38	13	robustness	robustness	NN
cord-000238-om92cx5q	38	14	.	.	.
cord-000238-om92cx5q	39	1	But	but	CC
cord-000238-om92cx5q	39	2	study	study	NN
cord-000238-om92cx5q	39	3	of	of	IN
cord-000238-om92cx5q	39	4	this	this	DT
cord-000238-om92cx5q	39	5	process	process	NN
cord-000238-om92cx5q	39	6	in	in	IN
cord-000238-om92cx5q	39	7	experimental	experimental	JJ
cord-000238-om92cx5q	39	8	populations	population	NNS
cord-000238-om92cx5q	39	9	is	be	VBZ
cord-000238-om92cx5q	39	10	problematic	problematic	JJ
cord-000238-om92cx5q	39	11	for	for	IN
cord-000238-om92cx5q	39	12	at	at	RB
cord-000238-om92cx5q	39	13	least	least	RBS
cord-000238-om92cx5q	39	14	two	two	CD
cord-000238-om92cx5q	39	15	reasons	reason	NNS
cord-000238-om92cx5q	39	16	:	:	:
cord-000238-om92cx5q	39	17	equilibrium	equilibrium	NN
cord-000238-om92cx5q	39	18	states	state	NNS
cord-000238-om92cx5q	39	19	are	be	VBP
cord-000238-om92cx5q	39	20	difficult	difficult	JJ
cord-000238-om92cx5q	39	21	to	to	TO
cord-000238-om92cx5q	39	22	achieve	achieve	VB
cord-000238-om92cx5q	39	23	͑or	͑or	NNP
cord-000238-om92cx5q	39	24	definitively	definitively	RB
cord-000238-om92cx5q	39	25	prove͒	prove͒	JJ
cord-000238-om92cx5q	39	26	in	in	IN
cord-000238-om92cx5q	39	27	lab	lab	NN
cord-000238-om92cx5q	39	28	-	-	HYPH
cord-000238-om92cx5q	39	29	evolved	evolve	VBN
cord-000238-om92cx5q	39	30	populations	population	NNS
cord-000238-om92cx5q	39	31	,	,	,
cord-000238-om92cx5q	39	32	and	and	CC
cord-000238-om92cx5q	39	33	selection	selection	NN
cord-000238-om92cx5q	39	34	for	for	IN
cord-000238-om92cx5q	39	35	mutational	mutational	JJ
cord-000238-om92cx5q	39	36	robustness	robustness	NN
cord-000238-om92cx5q	39	37	is	be	VBZ
cord-000238-om92cx5q	39	38	"	"	``
cord-000238-om92cx5q	39	39	second	second	JJ
cord-000238-om92cx5q	39	40	-	-	HYPH
cord-000238-om92cx5q	39	41	order	order	NN
cord-000238-om92cx5q	39	42	"	"	''
cord-000238-om92cx5q	39	43	because	because	IN
cord-000238-om92cx5q	39	44	the	the	DT
cord-000238-om92cx5q	39	45	benefit	benefit	NN
cord-000238-om92cx5q	39	46	is	be	VBZ
cord-000238-om92cx5q	39	47	not	not	RB
cord-000238-om92cx5q	39	48	experienced	experience	VBN
cord-000238-om92cx5q	39	49	until	until	IN
cord-000238-om92cx5q	39	50	offspring	offspring	NN
cord-000238-om92cx5q	39	51	carrying	carrying	NN
cord-000238-om92cx5q	39	52	mutations	mutation	NNS
cord-000238-om92cx5q	39	53	arise	arise	VBP
cord-000238-om92cx5q	39	54	.	.	.
cord-000238-om92cx5q	40	1	1	1	LS
cord-000238-om92cx5q	41	1	However	however	RB
cord-000238-om92cx5q	41	2	,	,	,
cord-000238-om92cx5q	41	3	theory	theory	NN
cord-000238-om92cx5q	41	4	and	and	CC
cord-000238-om92cx5q	41	5	artificial	artificial	JJ
cord-000238-om92cx5q	41	6	-	-	HYPH
cord-000238-om92cx5q	41	7	life	life	NN
cord-000238-om92cx5q	41	8	data	datum	NNS
cord-000238-om92cx5q	41	9	9	9	CD
cord-000238-om92cx5q	41	10	support	support	VBP
cord-000238-om92cx5q	41	11	the	the	DT
cord-000238-om92cx5q	41	12	idea	idea	NN
cord-000238-om92cx5q	41	13	that	that	IN
cord-000238-om92cx5q	41	14	genetic	genetic	JJ
cord-000238-om92cx5q	41	15	robustness	robustness	NN
cord-000238-om92cx5q	41	16	should	should	MD
cord-000238-om92cx5q	41	17	be	be	VB
cord-000238-om92cx5q	41	18	strongly	strongly	RB
cord-000238-om92cx5q	41	19	favored	favor	VBN
cord-000238-om92cx5q	41	20	when	when	WRB
cord-000238-om92cx5q	41	21	populations	population	NNS
cord-000238-om92cx5q	41	22	experience	experience	VBP
cord-000238-om92cx5q	41	23	elevated	elevated	JJ
cord-000238-om92cx5q	41	24	mutation	mutation	NN
cord-000238-om92cx5q	41	25	rates	rate	NNS
cord-000238-om92cx5q	41	26	,	,	,
cord-000238-om92cx5q	41	27	suggesting	suggest	VBG
cord-000238-om92cx5q	41	28	that	that	IN
cord-000238-om92cx5q	41	29	RNA	RNA	NNP
cord-000238-om92cx5q	41	30	viruses	virus	NNS
cord-000238-om92cx5q	41	31	would	would	MD
cord-000238-om92cx5q	41	32	be	be	VB
cord-000238-om92cx5q	41	33	fruitful	fruitful	JJ
cord-000238-om92cx5q	41	34	systems	system	NNS
cord-000238-om92cx5q	41	35	to	to	TO
cord-000238-om92cx5q	41	36	explore	explore	VB
cord-000238-om92cx5q	41	37	how	how	WRB
cord-000238-om92cx5q	41	38	genetic	genetic	JJ
cord-000238-om92cx5q	41	39	robustness	robustness	NN
cord-000238-om92cx5q	41	40	evolves	evolve	VBZ
cord-000238-om92cx5q	41	41	.	.	.
cord-000238-om92cx5q	42	1	In	in	IN
cord-000238-om92cx5q	42	2	general	general	JJ
cord-000238-om92cx5q	42	3	,	,	,
cord-000238-om92cx5q	42	4	success	success	NN
cord-000238-om92cx5q	42	5	in	in	IN
cord-000238-om92cx5q	42	6	these	these	DT
cord-000238-om92cx5q	42	7	systems	system	NNS
cord-000238-om92cx5q	42	8	has	have	VBZ
cord-000238-om92cx5q	42	9	come	come	VBN
cord-000238-om92cx5q	42	10	either	either	CC
cord-000238-om92cx5q	42	11	from	from	IN
cord-000238-om92cx5q	42	12	manipulating	manipulate	VBG
cord-000238-om92cx5q	42	13	ecological	ecological	JJ
cord-000238-om92cx5q	42	14	conditions	condition	NNS
cord-000238-om92cx5q	42	15	such	such	JJ
cord-000238-om92cx5q	42	16	that	that	IN
cord-000238-om92cx5q	42	17	robustness	robustness	NN
cord-000238-om92cx5q	42	18	becomes	become	VBZ
cord-000238-om92cx5q	42	19	less	less	RBR
cord-000238-om92cx5q	42	20	important	important	JJ
cord-000238-om92cx5q	42	21	and	and	CC
cord-000238-om92cx5q	42	22	evolves	evolve	VBZ
cord-000238-om92cx5q	42	23	to	to	TO
cord-000238-om92cx5q	42	24	decrease	decrease	VB
cord-000238-om92cx5q	42	25	,	,	,
cord-000238-om92cx5q	42	26	or	or	CC
cord-000238-om92cx5q	42	27	from	from	IN
cord-000238-om92cx5q	42	28	manipulating	manipulate	VBG
cord-000238-om92cx5q	42	29	competition	competition	NN
cord-000238-om92cx5q	42	30	environments	environment	NNS
cord-000238-om92cx5q	42	31	to	to	TO
cord-000238-om92cx5q	42	32	examine	examine	VB
cord-000238-om92cx5q	42	33	whether	whether	IN
cord-000238-om92cx5q	42	34	elevated	elevated	JJ
cord-000238-om92cx5q	42	35	mutation	mutation	NN
cord-000238-om92cx5q	42	36	rates	rate	NNS
cord-000238-om92cx5q	42	37	favor	favor	VBP
cord-000238-om92cx5q	42	38	genetically	genetically	RB
cord-000238-om92cx5q	42	39	robust	robust	JJ
cord-000238-om92cx5q	42	40	populations	population	NNS
cord-000238-om92cx5q	42	41	.	.	.
cord-000238-om92cx5q	43	1	In	in	IN
cord-000238-om92cx5q	43	2	both	both	DT
cord-000238-om92cx5q	43	3	strategies	strategy	NNS
cord-000238-om92cx5q	43	4	,	,	,
cord-000238-om92cx5q	43	5	the	the	DT
cord-000238-om92cx5q	43	6	ultimate	ultimate	JJ
cord-000238-om92cx5q	43	7	goal	goal	NN
cord-000238-om92cx5q	43	8	was	be	VBD
cord-000238-om92cx5q	43	9	to	to	TO
cord-000238-om92cx5q	43	10	manipulate	manipulate	VB
cord-000238-om92cx5q	43	11	treatments	treatment	NNS
cord-000238-om92cx5q	43	12	and	and	CC
cord-000238-om92cx5q	43	13	confirm	confirm	VB
cord-000238-om92cx5q	43	14	that	that	IN
cord-000238-om92cx5q	43	15	certain	certain	JJ
cord-000238-om92cx5q	43	16	test	test	NN
cord-000238-om92cx5q	43	17	populations	population	NNS
cord-000238-om92cx5q	43	18	better	well	RBR
cord-000238-om92cx5q	43	19	maintained	maintain	VBD
cord-000238-om92cx5q	43	20	a	a	DT
cord-000238-om92cx5q	43	21	measurable	measurable	JJ
cord-000238-om92cx5q	43	22	phenotype	phenotype	NN
cord-000238-om92cx5q	43	23	in	in	IN
cord-000238-om92cx5q	43	24	spite	spite	NN
cord-000238-om92cx5q	43	25	of	of	IN
cord-000238-om92cx5q	43	26	mutational	mutational	JJ
cord-000238-om92cx5q	43	27	change	change	NN
cord-000238-om92cx5q	43	28	,	,	,
cord-000238-om92cx5q	43	29	and	and	CC
cord-000238-om92cx5q	43	30	thus	thus	RB
cord-000238-om92cx5q	43	31	were	be	VBD
cord-000238-om92cx5q	43	32	relatively	relatively	RB
cord-000238-om92cx5q	43	33	robust	robust	JJ
cord-000238-om92cx5q	43	34	.	.	.
cord-000238-om92cx5q	44	1	Theory	theory	NN
cord-000238-om92cx5q	44	2	on	on	IN
cord-000238-om92cx5q	44	3	adaptive	adaptive	JJ
cord-000238-om92cx5q	44	4	genetic	genetic	JJ
cord-000238-om92cx5q	44	5	robustness	robustness	NN
cord-000238-om92cx5q	44	6	under	under	IN
cord-000238-om92cx5q	44	7	elevated	elevated	JJ
cord-000238-om92cx5q	44	8	mutation	mutation	NN
cord-000238-om92cx5q	44	9	rate	rate	NN
cord-000238-om92cx5q	44	10	generally	generally	RB
cord-000238-om92cx5q	44	11	assumes	assume	VBZ
cord-000238-om92cx5q	44	12	that	that	IN
cord-000238-om92cx5q	44	13	phenotype	phenotype	NN
cord-000238-om92cx5q	44	14	expression	expression	NN
cord-000238-om92cx5q	44	15	results	result	VBZ
cord-000238-om92cx5q	44	16	solely	solely	RB
cord-000238-om92cx5q	44	17	from	from	IN
cord-000238-om92cx5q	44	18	the	the	DT
cord-000238-om92cx5q	44	19	underlying	underlie	VBG
cord-000238-om92cx5q	44	20	genotype	genotype	NN
cord-000238-om92cx5q	44	21	.	.	.
cord-000238-om92cx5q	45	1	However	however	RB
cord-000238-om92cx5q	45	2	,	,	,
cord-000238-om92cx5q	45	3	viruses	virus	NNS
cord-000238-om92cx5q	45	4	can	can	MD
cord-000238-om92cx5q	45	5	employ	employ	VB
cord-000238-om92cx5q	45	6	complementation	complementation	NN
cord-000238-om92cx5q	45	7	,	,	,
cord-000238-om92cx5q	45	8	a	a	DT
cord-000238-om92cx5q	45	9	mechanism	mechanism	NN
cord-000238-om92cx5q	45	10	whereby	whereby	WRB
cord-000238-om92cx5q	45	11	low	low	JJ
cord-000238-om92cx5q	45	12	-	-	HYPH
cord-000238-om92cx5q	45	13	fitness	fitness	NN
cord-000238-om92cx5q	45	14	genotypes	genotype	NNS
cord-000238-om92cx5q	45	15	can	can	MD
cord-000238-om92cx5q	45	16	use	use	VB
cord-000238-om92cx5q	45	17	,	,	,
cord-000238-om92cx5q	45	18	to	to	IN
cord-000238-om92cx5q	45	19	their	-PRON-	PRP$
cord-000238-om92cx5q	45	20	advantage	advantage	NN
cord-000238-om92cx5q	45	21	,	,	,
cord-000238-om92cx5q	45	22	intracellular	intracellular	JJ
cord-000238-om92cx5q	45	23	proteins	protein	NNS
cord-000238-om92cx5q	45	24	made	make	VBN
cord-000238-om92cx5q	45	25	by	by	IN
cord-000238-om92cx5q	45	26	coinfecting	coinfecte	VBG
cord-000238-om92cx5q	45	27	strains	strain	NNS
cord-000238-om92cx5q	45	28	of	of	IN
cord-000238-om92cx5q	45	29	high	high	JJ
cord-000238-om92cx5q	45	30	fitness	fitness	NN
cord-000238-om92cx5q	45	31	.	.	.
cord-000238-om92cx5q	46	1	[	[	-LRB-
cord-000238-om92cx5q	46	2	19	19	CD
cord-000238-om92cx5q	46	3	]	]	-RRB-
cord-000238-om92cx5q	46	4	[	[	-LRB-
cord-000238-om92cx5q	46	5	20	20	CD
cord-000238-om92cx5q	46	6	]	]	-RRB-
cord-000238-om92cx5q	46	7	[	[	-LRB-
cord-000238-om92cx5q	46	8	21	21	CD
cord-000238-om92cx5q	46	9	]	]	-RRB-
cord-000238-om92cx5q	46	10	Coinfection	coinfection	NN
cord-000238-om92cx5q	46	11	combined	combine	VBN
cord-000238-om92cx5q	46	12	with	with	IN
cord-000238-om92cx5q	46	13	complementation	complementation	NN
cord-000238-om92cx5q	46	14	can	can	MD
cord-000238-om92cx5q	46	15	therefore	therefore	RB
cord-000238-om92cx5q	46	16	provide	provide	VB
cord-000238-om92cx5q	46	17	phenotypic	phenotypic	JJ
cord-000238-om92cx5q	46	18	buffering	buffering	NN
cord-000238-om92cx5q	46	19	in	in	IN
cord-000238-om92cx5q	46	20	the	the	DT
cord-000238-om92cx5q	46	21	event	event	NN
cord-000238-om92cx5q	46	22	of	of	IN
cord-000238-om92cx5q	46	23	genomic	genomic	JJ
cord-000238-om92cx5q	46	24	mutations	mutation	NNS
cord-000238-om92cx5q	46	25	,	,	,
cord-000238-om92cx5q	46	26	similar	similar	JJ
cord-000238-om92cx5q	46	27	to	to	IN
cord-000238-om92cx5q	46	28	other	other	JJ
cord-000238-om92cx5q	46	29	buffering	buffering	NN
cord-000238-om92cx5q	46	30	mechanisms	mechanism	NNS
cord-000238-om92cx5q	46	31	such	such	JJ
cord-000238-om92cx5q	46	32	as	as	IN
cord-000238-om92cx5q	46	33	gene	gene	NN
cord-000238-om92cx5q	46	34	duplication	duplication	NN
cord-000238-om92cx5q	46	35	and	and	CC
cord-000238-om92cx5q	46	36	diploidy	diploidy	NN
cord-000238-om92cx5q	46	37	that	that	WDT
cord-000238-om92cx5q	46	38	might	may	MD
cord-000238-om92cx5q	46	39	be	be	VB
cord-000238-om92cx5q	46	40	positively	positively	RB
cord-000238-om92cx5q	46	41	selected	select	VBN
cord-000238-om92cx5q	46	42	because	because	IN
cord-000238-om92cx5q	46	43	they	-PRON-	PRP
cord-000238-om92cx5q	46	44	facilitate	facilitate	VBP
cord-000238-om92cx5q	46	45	canalization	canalization	NN
cord-000238-om92cx5q	46	46	in	in	IN
cord-000238-om92cx5q	46	47	higher	high	JJR
cord-000238-om92cx5q	46	48	organisms	organism	NNS
cord-000238-om92cx5q	46	49	.	.	.
cord-000238-om92cx5q	47	1	22	22	CD
cord-000238-om92cx5q	47	2	,	,	,
cord-000238-om92cx5q	47	3	23	23	CD
cord-000238-om92cx5q	47	4	Complementation	Complementation	NNP
cord-000238-om92cx5q	47	5	can	can	MD
cord-000238-om92cx5q	47	6	buffer	buffer	VB
cord-000238-om92cx5q	47	7	against	against	IN
cord-000238-om92cx5q	47	8	negative	negative	JJ
cord-000238-om92cx5q	47	9	fitness	fitness	NN
cord-000238-om92cx5q	47	10	effects	effect	NNS
cord-000238-om92cx5q	47	11	of	of	IN
cord-000238-om92cx5q	47	12	deleterious	deleterious	JJ
cord-000238-om92cx5q	47	13	alleles	allele	NNS
cord-000238-om92cx5q	47	14	in	in	IN
cord-000238-om92cx5q	47	15	coinfecting	coinfecte	VBG
cord-000238-om92cx5q	47	16	populations	population	NNS
cord-000238-om92cx5q	47	17	of	of	IN
cord-000238-om92cx5q	47	18	viruses	virus	NNS
cord-000238-om92cx5q	47	19	.	.	.
cord-000238-om92cx5q	48	1	20	20	CD
cord-000238-om92cx5q	49	1	This	this	DT
cord-000238-om92cx5q	49	2	buffering	buffering	NN
cord-000238-om92cx5q	49	3	effect	effect	NN
cord-000238-om92cx5q	49	4	introduces	introduce	VBZ
cord-000238-om92cx5q	49	5	an	an	DT
cord-000238-om92cx5q	49	6	ecologically	ecologically	RB
cord-000238-om92cx5q	49	7	determined	determine	VBN
cord-000238-om92cx5q	49	8	community	community	NN
cord-000238-om92cx5q	49	9	-	-	HYPH
cord-000238-om92cx5q	49	10	level	level	NN
cord-000238-om92cx5q	49	11	robustness	robustness	NN
cord-000238-om92cx5q	49	12	which	which	WDT
cord-000238-om92cx5q	49	13	renders	render	VBZ
cord-000238-om92cx5q	49	14	their	-PRON-	PRP$
cord-000238-om92cx5q	49	15	individuallevel	individuallevel	NN
cord-000238-om92cx5q	49	16	robustness	robustness	NN
cord-000238-om92cx5q	49	17	less	less	RBR
cord-000238-om92cx5q	49	18	necessary	necessary	JJ
cord-000238-om92cx5q	49	19	.	.	.
cord-000238-om92cx5q	50	1	This	this	DT
cord-000238-om92cx5q	50	2	logic	logic	NN
cord-000238-om92cx5q	50	3	infers	infer	VBZ
cord-000238-om92cx5q	50	4	that	that	IN
cord-000238-om92cx5q	50	5	the	the	DT
cord-000238-om92cx5q	50	6	degree	degree	NN
cord-000238-om92cx5q	50	7	of	of	IN
cord-000238-om92cx5q	50	8	coinfection	coinfection	NN
cord-000238-om92cx5q	50	9	-	-	HYPH
cord-000238-om92cx5q	50	10	high	high	JJ
cord-000238-om92cx5q	50	11	multiplicity	multiplicity	NN
cord-000238-om92cx5q	50	12	of	of	IN
cord-000238-om92cx5q	50	13	infection	infection	NN
cord-000238-om92cx5q	50	14	͑MOI	͑MOI	NNP
cord-000238-om92cx5q	50	15	;	;	:
cord-000238-om92cx5q	50	16	ratio	ratio	NN
cord-000238-om92cx5q	50	17	of	of	IN
cord-000238-om92cx5q	50	18	viruses	virus	NNS
cord-000238-om92cx5q	50	19	to	to	IN
cord-000238-om92cx5q	50	20	cells͒	cells͒	VB
cord-000238-om92cx5q	50	21	versus	versus	IN
cord-000238-om92cx5q	50	22	low	low	JJ
cord-000238-om92cx5q	50	23	MOI	MOI	NNP
cord-000238-om92cx5q	50	24	-	-	,
cord-000238-om92cx5q	50	25	should	should	MD
cord-000238-om92cx5q	50	26	influence	influence	VB
cord-000238-om92cx5q	50	27	evolution	evolution	NN
cord-000238-om92cx5q	50	28	of	of	IN
cord-000238-om92cx5q	50	29	robustness	robustness	NN
cord-000238-om92cx5q	50	30	in	in	IN
cord-000238-om92cx5q	50	31	virus	virus	NN
cord-000238-om92cx5q	50	32	populations	population	NNS
cord-000238-om92cx5q	50	33	.	.	.
cord-000238-om92cx5q	51	1	14	14	CD
cord-000238-om92cx5q	52	1	We	-PRON-	PRP
cord-000238-om92cx5q	52	2	note	note	VBP
cord-000238-om92cx5q	52	3	that	that	IN
cord-000238-om92cx5q	52	4	many	many	JJ
cord-000238-om92cx5q	52	5	other	other	JJ
cord-000238-om92cx5q	52	6	phenomena	phenomenon	NNS
cord-000238-om92cx5q	52	7	consequential	consequential	JJ
cord-000238-om92cx5q	52	8	for	for	IN
cord-000238-om92cx5q	52	9	virus	virus	NN
cord-000238-om92cx5q	52	10	evolution	evolution	NN
cord-000238-om92cx5q	52	11	can	can	MD
cord-000238-om92cx5q	52	12	occur	occur	VB
cord-000238-om92cx5q	52	13	as	as	IN
cord-000238-om92cx5q	52	14	a	a	DT
cord-000238-om92cx5q	52	15	result	result	NN
cord-000238-om92cx5q	52	16	of	of	IN
cord-000238-om92cx5q	52	17	coinfection	coinfection	NN
cord-000238-om92cx5q	52	18	,	,	,
cord-000238-om92cx5q	52	19	especially	especially	RB
cord-000238-om92cx5q	52	20	genetic	genetic	JJ
cord-000238-om92cx5q	52	21	exchange	exchange	NN
cord-000238-om92cx5q	52	22	͑recombination͒	͑recombination͒	NFP
cord-000238-om92cx5q	52	23	between	between	IN
cord-000238-om92cx5q	52	24	viruses	virus	NNS
cord-000238-om92cx5q	52	25	and	and	CC
cord-000238-om92cx5q	52	26	selection	selection	NN
cord-000238-om92cx5q	52	27	for	for	IN
cord-000238-om92cx5q	52	28	virus	virus	NN
cord-000238-om92cx5q	52	29	"	"	``
cord-000238-om92cx5q	52	30	cheaters	cheater	NNS
cord-000238-om92cx5q	52	31	"	"	''
cord-000238-om92cx5q	52	32	such	such	JJ
cord-000238-om92cx5q	52	33	as	as	IN
cord-000238-om92cx5q	52	34	defective	defective	JJ
cord-000238-om92cx5q	52	35	-	-	HYPH
cord-000238-om92cx5q	52	36	interfering	interfere	VBG
cord-000238-om92cx5q	52	37	particles	particle	NNS
cord-000238-om92cx5q	52	38	.	.	.
cord-000238-om92cx5q	53	1	24	24	CD
cord-000238-om92cx5q	54	1	For	for	IN
cord-000238-om92cx5q	54	2	brevity	brevity	NN
cord-000238-om92cx5q	54	3	we	-PRON-	PRP
cord-000238-om92cx5q	54	4	limit	limit	VBP
cord-000238-om92cx5q	54	5	our	-PRON-	PRP$
cord-000238-om92cx5q	54	6	discussion	discussion	NN
cord-000238-om92cx5q	54	7	to	to	IN
cord-000238-om92cx5q	54	8	complementation	complementation	NN
cord-000238-om92cx5q	54	9	that	that	WDT
cord-000238-om92cx5q	54	10	occurs	occur	VBZ
cord-000238-om92cx5q	54	11	during	during	IN
cord-000238-om92cx5q	54	12	coinfection	coinfection	NN
cord-000238-om92cx5q	54	13	and	and	CC
cord-000238-om92cx5q	54	14	its	-PRON-	PRP$
cord-000238-om92cx5q	54	15	potential	potential	JJ
cord-000238-om92cx5q	54	16	role	role	NN
cord-000238-om92cx5q	54	17	in	in	IN
cord-000238-om92cx5q	54	18	the	the	DT
cord-000238-om92cx5q	54	19	evolution	evolution	NN
cord-000238-om92cx5q	54	20	of	of	IN
cord-000238-om92cx5q	54	21	virus	virus	NN
cord-000238-om92cx5q	54	22	robustness	robustness	NN
cord-000238-om92cx5q	54	23	.	.	.
cord-000238-om92cx5q	55	1	The	the	DT
cord-000238-om92cx5q	55	2	segmented	segmented	JJ
cord-000238-om92cx5q	55	3	RNA	RNA	NNP
cord-000238-om92cx5q	55	4	phage	phage	NN
cord-000238-om92cx5q	55	5	6	6	CD
cord-000238-om92cx5q	55	6	is	be	VBZ
cord-000238-om92cx5q	55	7	typically	typically	RB
cord-000238-om92cx5q	55	8	grown	grow	VBN
cord-000238-om92cx5q	55	9	in	in	IN
cord-000238-om92cx5q	55	10	the	the	DT
cord-000238-om92cx5q	55	11	laboratory	laboratory	NN
cord-000238-om92cx5q	55	12	on	on	IN
cord-000238-om92cx5q	55	13	the	the	DT
cord-000238-om92cx5q	55	14	plant	plant	NN
cord-000238-om92cx5q	55	15	pathogenic	pathogenic	JJ
cord-000238-om92cx5q	55	16	bacteria	bacteria	NNS
cord-000238-om92cx5q	55	17	Pseudomonas	Pseudomonas	NNP
cord-000238-om92cx5q	55	18	syringae	syringae	NN
cord-000238-om92cx5q	55	19	pathovar	pathovar	NNP
cord-000238-om92cx5q	55	20	phaseolicola	phaseolicola	NNP
cord-000238-om92cx5q	55	21	.	.	.
cord-000238-om92cx5q	56	1	To	to	TO
cord-000238-om92cx5q	56	2	examine	examine	VB
cord-000238-om92cx5q	56	3	whether	whether	IN
cord-000238-om92cx5q	56	4	high	high	JJ
cord-000238-om92cx5q	56	5	-	-	HYPH
cord-000238-om92cx5q	56	6	MOI	MOI	NNP
cord-000238-om92cx5q	56	7	populations	population	NNS
cord-000238-om92cx5q	56	8	of	of	IN
cord-000238-om92cx5q	56	9	phage	phage	NN
cord-000238-om92cx5q	56	10	6	6	CD
cord-000238-om92cx5q	56	11	will	will	MD
cord-000238-om92cx5q	56	12	evolve	evolve	VB
cord-000238-om92cx5q	56	13	decreased	decrease	VBN
cord-000238-om92cx5q	56	14	genetic	genetic	JJ
cord-000238-om92cx5q	56	15	robustness	robustness	NN
cord-000238-om92cx5q	56	16	against	against	IN
cord-000238-om92cx5q	56	17	mutations	mutation	NNS
cord-000238-om92cx5q	56	18	,	,	,
cord-000238-om92cx5q	56	19	virus	virus	NN
cord-000238-om92cx5q	56	20	populations	population	NNS
cord-000238-om92cx5q	56	21	were	be	VBD
cord-000238-om92cx5q	56	22	first	first	RB
cord-000238-om92cx5q	56	23	propagated	propagate	VBN
cord-000238-om92cx5q	56	24	for	for	IN
cord-000238-om92cx5q	56	25	300	300	CD
cord-000238-om92cx5q	56	26	generations	generation	NNS
cord-000238-om92cx5q	56	27	under	under	IN
cord-000238-om92cx5q	56	28	high	high	JJ
cord-000238-om92cx5q	56	29	versus	versus	IN
cord-000238-om92cx5q	56	30	low	low	JJ
cord-000238-om92cx5q	56	31	MOI	MOI	NNP
cord-000238-om92cx5q	56	32	.	.	.
cord-000238-om92cx5q	57	1	25	25	CD
cord-000238-om92cx5q	57	2	,	,	,
cord-000238-om92cx5q	57	3	14	14	CD
cord-000238-om92cx5q	58	1	The	the	DT
cord-000238-om92cx5q	58	2	expectation	expectation	NN
cord-000238-om92cx5q	58	3	was	be	VBD
cord-000238-om92cx5q	58	4	that	that	IN
cord-000238-om92cx5q	58	5	high	high	JJ
cord-000238-om92cx5q	58	6	-	-	HYPH
cord-000238-om92cx5q	58	7	MOI	MOI	NNP
cord-000238-om92cx5q	58	8	evolved	evolve	VBD
cord-000238-om92cx5q	58	9	viruses	virus	NNS
cord-000238-om92cx5q	58	10	would	would	MD
cord-000238-om92cx5q	58	11	become	become	VB
cord-000238-om92cx5q	58	12	more	more	RBR
cord-000238-om92cx5q	58	13	brittle	brittle	JJ
cord-000238-om92cx5q	58	14	,	,	,
cord-000238-om92cx5q	58	15	in	in	IN
cord-000238-om92cx5q	58	16	comparison	comparison	NN
cord-000238-om92cx5q	58	17	to	to	IN
cord-000238-om92cx5q	58	18	their	-PRON-	PRP$
cord-000238-om92cx5q	58	19	low	low	JJ
cord-000238-om92cx5q	58	20	-	-	HYPH
cord-000238-om92cx5q	58	21	MOI	MOI	NNP
cord-000238-om92cx5q	58	22	evolved	evolve	VBD
cord-000238-om92cx5q	58	23	counterparts	counterpart	NNS
cord-000238-om92cx5q	58	24	.	.	.
cord-000238-om92cx5q	59	1	To	to	TO
cord-000238-om92cx5q	59	2	reveal	reveal	VB
cord-000238-om92cx5q	59	3	this	this	DT
cord-000238-om92cx5q	59	4	assumed	assume	VBN
cord-000238-om92cx5q	59	5	outcome	outcome	NN
cord-000238-om92cx5q	59	6	,	,	,
cord-000238-om92cx5q	59	7	clones	clone	NNS
cord-000238-om92cx5q	59	8	were	be	VBD
cord-000238-om92cx5q	59	9	randomly	randomly	RB
cord-000238-om92cx5q	59	10	chosen	choose	VBN
cord-000238-om92cx5q	59	11	from	from	IN
cord-000238-om92cx5q	59	12	the	the	DT
cord-000238-om92cx5q	59	13	treatment	treatment	NN
cord-000238-om92cx5q	59	14	populations	population	NNS
cord-000238-om92cx5q	59	15	and	and	CC
cord-000238-om92cx5q	59	16	used	use	VBD
cord-000238-om92cx5q	59	17	to	to	TO
cord-000238-om92cx5q	59	18	initiate	initiate	VB
cord-000238-om92cx5q	59	19	lineages	lineage	NNS
cord-000238-om92cx5q	59	20	subjected	subject	VBN
cord-000238-om92cx5q	59	21	to	to	IN
cord-000238-om92cx5q	59	22	mutation	mutation	NN
cord-000238-om92cx5q	59	23	accumulation	accumulation	NN
cord-000238-om92cx5q	59	24	via	via	IN
cord-000238-om92cx5q	59	25	passage	passage	NN
cord-000238-om92cx5q	59	26	through	through	IN
cord-000238-om92cx5q	59	27	severe	severe	JJ
cord-000238-om92cx5q	59	28	bottlenecks	bottleneck	NNS
cord-000238-om92cx5q	59	29	͑population	͑population	SYM
cord-000238-om92cx5q	59	30	size=	size=	NNS
cord-000238-om92cx5q	59	31	1	1	CD
cord-000238-om92cx5q	59	32	individual͒	individual͒	CD
cord-000238-om92cx5q	59	33	;	;	:
cord-000238-om92cx5q	59	34	this	this	DT
cord-000238-om92cx5q	59	35	method	method	NN
cord-000238-om92cx5q	59	36	allows	allow	VBZ
cord-000238-om92cx5q	59	37	genetic	genetic	JJ
cord-000238-om92cx5q	59	38	drift	drift	NN
cord-000238-om92cx5q	59	39	to	to	TO
cord-000238-om92cx5q	59	40	overwhelm	overwhelm	VB
cord-000238-om92cx5q	59	41	selection	selection	NN
cord-000238-om92cx5q	59	42	,	,	,
cord-000238-om92cx5q	59	43	such	such	JJ
cord-000238-om92cx5q	59	44	that	that	IN
cord-000238-om92cx5q	59	45	virus	virus	NN
cord-000238-om92cx5q	59	46	lineages	lineage	NNS
cord-000238-om92cx5q	59	47	amass	amass	VBP
cord-000238-om92cx5q	59	48	mutations	mutation	NNS
cord-000238-om92cx5q	59	49	that	that	WDT
cord-000238-om92cx5q	59	50	are	be	VBP
cord-000238-om92cx5q	59	51	on	on	IN
cord-000238-om92cx5q	59	52	average	average	JJ
cord-000238-om92cx5q	59	53	deleterious	deleterious	JJ
cord-000238-om92cx5q	59	54	.	.	.
cord-000238-om92cx5q	60	1	26	26	CD
cord-000238-om92cx5q	61	1	The	the	DT
cord-000238-om92cx5q	61	2	mean	mean	JJ
cord-000238-om92cx5q	61	3	magnitude	magnitude	NN
cord-000238-om92cx5q	61	4	and	and	CC
cord-000238-om92cx5q	61	5	FIG	fig	NN
cord-000238-om92cx5q	61	6	.	.	.
cord-000238-om92cx5q	62	1	1	1	LS
cord-000238-om92cx5q	62	2	.	.	.
cord-000238-om92cx5q	63	1	Genotype	genotype	NN
cord-000238-om92cx5q	63	2	and	and	CC
cord-000238-om92cx5q	63	3	phenotype	phenotype	NN
cord-000238-om92cx5q	63	4	spaces	space	NNS
cord-000238-om92cx5q	63	5	are	be	VBP
cord-000238-om92cx5q	63	6	represented	represent	VBN
cord-000238-om92cx5q	63	7	schematically	schematically	RB
cord-000238-om92cx5q	63	8	in	in	IN
cord-000238-om92cx5q	63	9	two	two	CD
cord-000238-om92cx5q	63	10	dimensions	dimension	NNS
cord-000238-om92cx5q	63	11	.	.	.
cord-000238-om92cx5q	64	1	A	a	DT
cord-000238-om92cx5q	64	2	brittle	brittle	JJ
cord-000238-om92cx5q	64	3	organism	organism	NN
cord-000238-om92cx5q	64	4	produces	produce	VBZ
cord-000238-om92cx5q	64	5	a	a	DT
cord-000238-om92cx5q	64	6	phenotype	phenotype	NN
cord-000238-om92cx5q	64	7	that	that	WDT
cord-000238-om92cx5q	64	8	is	be	VBZ
cord-000238-om92cx5q	64	9	a	a	DT
cord-000238-om92cx5q	64	10	reflection	reflection	NN
cord-000238-om92cx5q	64	11	of	of	IN
cord-000238-om92cx5q	64	12	the	the	DT
cord-000238-om92cx5q	64	13	underlying	underlying	JJ
cord-000238-om92cx5q	64	14	genotype	genotype	NN
cord-000238-om92cx5q	64	15	,	,	,
cord-000238-om92cx5q	64	16	whereas	whereas	IN
cord-000238-om92cx5q	64	17	a	a	DT
cord-000238-om92cx5q	64	18	robust	robust	JJ
cord-000238-om92cx5q	64	19	organism	organism	NN
cord-000238-om92cx5q	64	20	produces	produce	VBZ
cord-000238-om92cx5q	64	21	a	a	DT
cord-000238-om92cx5q	64	22	constant	constant	JJ
cord-000238-om92cx5q	64	23	phenotype	phenotype	NN
cord-000238-om92cx5q	64	24	regardless	regardless	RB
cord-000238-om92cx5q	64	25	of	of	IN
cord-000238-om92cx5q	64	26	the	the	DT
cord-000238-om92cx5q	64	27	underlying	underlying	JJ
cord-000238-om92cx5q	64	28	genotype	genotype	NN
cord-000238-om92cx5q	64	29	.	.	.
cord-000238-om92cx5q	65	1	͓Reprinted	͓reprinte	VBN
cord-000238-om92cx5q	65	2	with	with	IN
cord-000238-om92cx5q	65	3	permission	permission	NN
cord-000238-om92cx5q	65	4	from	from	IN
cord-000238-om92cx5q	65	5	M.	M.	NNP
cord-000238-om92cx5q	65	6	Félix	Félix	NNP
cord-000238-om92cx5q	65	7	and	and	CC
cord-000238-om92cx5q	65	8	A.	A.	NNP
cord-000238-om92cx5q	65	9	Wagner	Wagner	NNP
cord-000238-om92cx5q	65	10	,	,	,
cord-000238-om92cx5q	65	11	Heredity	Heredity	NNP
cord-000238-om92cx5q	65	12	100	100	CD
cord-000238-om92cx5q	65	13	,	,	,
cord-000238-om92cx5q	65	14	132	132	CD
cord-000238-om92cx5q	65	15	͑2008͒.	͑2008͒.	.
cord-000238-om92cx5q	66	1	Copyright	copyright	NN
cord-000238-om92cx5q	66	2	©	©	NNP
cord-000238-om92cx5q	66	3	2008	2008	CD
cord-000238-om92cx5q	66	4	Nature	Nature	NNP
cord-000238-om92cx5q	66	5	Publishing	Publishing	NNP
cord-000238-om92cx5q	66	6	Group.͔	Group.͔	NNP
cord-000238-om92cx5q	66	7	variance	variance	NN
cord-000238-om92cx5q	66	8	in	in	IN
cord-000238-om92cx5q	66	9	fitness	fitness	NN
cord-000238-om92cx5q	66	10	changes	change	NNS
cord-000238-om92cx5q	66	11	that	that	WDT
cord-000238-om92cx5q	66	12	occurred	occur	VBD
cord-000238-om92cx5q	66	13	because	because	IN
cord-000238-om92cx5q	66	14	of	of	IN
cord-000238-om92cx5q	66	15	bottlenecking	bottleneck	VBG
cord-000238-om92cx5q	66	16	were	be	VBD
cord-000238-om92cx5q	66	17	statistically	statistically	RB
cord-000238-om92cx5q	66	18	compared	compare	VBN
cord-000238-om92cx5q	66	19	between	between	IN
cord-000238-om92cx5q	66	20	lineages	lineage	NNS
cord-000238-om92cx5q	66	21	founded	found	VBN
cord-000238-om92cx5q	66	22	by	by	IN
cord-000238-om92cx5q	66	23	presumed	presume	VBN
cord-000238-om92cx5q	66	24	robust	robust	JJ
cord-000238-om92cx5q	66	25	͑low	͑low	NNP
cord-000238-om92cx5q	66	26	-	-	:
cord-000238-om92cx5q	66	27	MOI͒	moi͒	JJ
cord-000238-om92cx5q	66	28	and	and	CC
cord-000238-om92cx5q	66	29	brittle	brittle	JJ
cord-000238-om92cx5q	66	30	͑high	͑high	NN
cord-000238-om92cx5q	66	31	-	-	:
cord-000238-om92cx5q	66	32	MOI͒	moi͒	JJ
cord-000238-om92cx5q	66	33	viruses	virus	NNS
cord-000238-om92cx5q	66	34	.	.	.
cord-000238-om92cx5q	67	1	Results	result	NNS
cord-000238-om92cx5q	67	2	from	from	IN
cord-000238-om92cx5q	67	3	the	the	DT
cord-000238-om92cx5q	67	4	mutation	mutation	NN
cord-000238-om92cx5q	67	5	accumulation	accumulation	NN
cord-000238-om92cx5q	67	6	analysis	analysis	NN
cord-000238-om92cx5q	67	7	supported	support	VBD
cord-000238-om92cx5q	67	8	the	the	DT
cord-000238-om92cx5q	67	9	hypothesis	hypothesis	NN
cord-000238-om92cx5q	67	10	that	that	IN
cord-000238-om92cx5q	67	11	viruses	virus	NNS
cord-000238-om92cx5q	67	12	historically	historically	RB
cord-000238-om92cx5q	67	13	evolved	evolve	VBN
cord-000238-om92cx5q	67	14	under	under	IN
cord-000238-om92cx5q	67	15	frequent	frequent	JJ
cord-000238-om92cx5q	67	16	coinfection	coinfection	NN
cord-000238-om92cx5q	67	17	became	become	VBD
cord-000238-om92cx5q	67	18	relatively	relatively	RB
cord-000238-om92cx5q	67	19	less	less	RBR
cord-000238-om92cx5q	67	20	genetically	genetically	RB
cord-000238-om92cx5q	67	21	robust	robust	JJ
cord-000238-om92cx5q	67	22	than	than	IN
cord-000238-om92cx5q	67	23	those	those	DT
cord-000238-om92cx5q	67	24	evolved	evolve	VBN
cord-000238-om92cx5q	67	25	under	under	IN
cord-000238-om92cx5q	67	26	rare	rare	JJ
cord-000238-om92cx5q	67	27	coinfection	coinfection	NN
cord-000238-om92cx5q	67	28	.	.	.
cord-000238-om92cx5q	68	1	14	14	CD
cord-000238-om92cx5q	69	1	One	one	CD
cord-000238-om92cx5q	69	2	alternative	alternative	JJ
cord-000238-om92cx5q	69	3	explanation	explanation	NN
cord-000238-om92cx5q	69	4	for	for	IN
cord-000238-om92cx5q	69	5	the	the	DT
cord-000238-om92cx5q	69	6	observations	observation	NNS
cord-000238-om92cx5q	69	7	would	would	MD
cord-000238-om92cx5q	69	8	be	be	VB
cord-000238-om92cx5q	69	9	a	a	DT
cord-000238-om92cx5q	69	10	higher	high	JJR
cord-000238-om92cx5q	69	11	mutation	mutation	NN
cord-000238-om92cx5q	69	12	rate	rate	NN
cord-000238-om92cx5q	69	13	in	in	IN
cord-000238-om92cx5q	69	14	the	the	DT
cord-000238-om92cx5q	69	15	viruses	virus	NNS
cord-000238-om92cx5q	69	16	evolved	evolve	VBN
cord-000238-om92cx5q	69	17	at	at	IN
cord-000238-om92cx5q	69	18	high	high	JJ
cord-000238-om92cx5q	69	19	MOI	MOI	NNP
cord-000238-om92cx5q	69	20	,	,	,
cord-000238-om92cx5q	69	21	causing	cause	VBG
cord-000238-om92cx5q	69	22	them	-PRON-	PRP
cord-000238-om92cx5q	69	23	to	to	TO
cord-000238-om92cx5q	69	24	experience	experience	VB
cord-000238-om92cx5q	69	25	a	a	DT
cord-000238-om92cx5q	69	26	greater	great	JJR
cord-000238-om92cx5q	69	27	number	number	NN
cord-000238-om92cx5q	69	28	of	of	IN
cord-000238-om92cx5q	69	29	fixed	fix	VBN
cord-000238-om92cx5q	69	30	mutations	mutation	NNS
cord-000238-om92cx5q	69	31	͑and	͑and	.
cord-000238-om92cx5q	70	1	hence	hence	RB
cord-000238-om92cx5q	70	2	,	,	,
cord-000238-om92cx5q	70	3	greater	great	JJR
cord-000238-om92cx5q	70	4	fitness	fitness	NN
cord-000238-om92cx5q	70	5	loss͒	loss͒	JJ
cord-000238-om92cx5q	70	6	during	during	IN
cord-000238-om92cx5q	70	7	the	the	DT
cord-000238-om92cx5q	70	8	mutation	mutation	NN
cord-000238-om92cx5q	70	9	accumulation	accumulation	NN
cord-000238-om92cx5q	70	10	;	;	:
cord-000238-om92cx5q	70	11	however	however	RB
cord-000238-om92cx5q	70	12	,	,	,
cord-000238-om92cx5q	70	13	no	no	DT
cord-000238-om92cx5q	70	14	evidence	evidence	NN
cord-000238-om92cx5q	70	15	suggests	suggest	VBZ
cord-000238-om92cx5q	70	16	that	that	IN
cord-000238-om92cx5q	70	17	these	these	DT
cord-000238-om92cx5q	70	18	viruses	virus	NNS
cord-000238-om92cx5q	70	19	mutate	mutate	VBP
cord-000238-om92cx5q	70	20	at	at	IN
cord-000238-om92cx5q	70	21	rates	rate	NNS
cord-000238-om92cx5q	70	22	higher	high	JJR
cord-000238-om92cx5q	70	23	than	than	IN
cord-000238-om92cx5q	70	24	their	-PRON-	PRP$
cord-000238-om92cx5q	70	25	counterparts	counterpart	NNS
cord-000238-om92cx5q	70	26	evolved	evolve	VBD
cord-000238-om92cx5q	70	27	at	at	IN
cord-000238-om92cx5q	70	28	low	low	JJ
cord-000238-om92cx5q	70	29	MOI	MOI	NNP
cord-000238-om92cx5q	70	30	.	.	.
cord-000238-om92cx5q	71	1	14	14	CD
cord-000238-om92cx5q	71	2	,	,	,
cord-000238-om92cx5q	71	3	15	15	CD
cord-000238-om92cx5q	72	1	Thus	thus	RB
cord-000238-om92cx5q	72	2	,	,	,
cord-000238-om92cx5q	72	3	the	the	DT
cord-000238-om92cx5q	72	4	study	study	NN
cord-000238-om92cx5q	72	5	provided	provide	VBD
cord-000238-om92cx5q	72	6	the	the	DT
cord-000238-om92cx5q	72	7	first	first	JJ
cord-000238-om92cx5q	72	8	evidence	evidence	NN
cord-000238-om92cx5q	72	9	that	that	IN
cord-000238-om92cx5q	72	10	genetic	genetic	JJ
cord-000238-om92cx5q	72	11	robustness	robustness	NN
cord-000238-om92cx5q	72	12	could	could	MD
cord-000238-om92cx5q	72	13	evolve	evolve	VB
cord-000238-om92cx5q	72	14	to	to	TO
cord-000238-om92cx5q	72	15	change	change	VB
cord-000238-om92cx5q	72	16	in	in	IN
cord-000238-om92cx5q	72	17	biological	biological	JJ
cord-000238-om92cx5q	72	18	populations	population	NNS
cord-000238-om92cx5q	72	19	.	.	.
cord-000238-om92cx5q	73	1	Other	other	JJ
cord-000238-om92cx5q	73	2	experimental	experimental	JJ
cord-000238-om92cx5q	73	3	studies	study	NNS
cord-000238-om92cx5q	73	4	have	have	VBP
cord-000238-om92cx5q	73	5	used	use	VBN
cord-000238-om92cx5q	73	6	RNA	RNA	NNP
cord-000238-om92cx5q	73	7	viruses	virus	NNS
cord-000238-om92cx5q	73	8	or	or	CC
cord-000238-om92cx5q	73	9	viroids	viroid	NNS
cord-000238-om92cx5q	73	10	͑RNA	͑RNA	,
cord-000238-om92cx5q	73	11	viruslike	viruslike	JJ
cord-000238-om92cx5q	73	12	plant	plant	NN
cord-000238-om92cx5q	73	13	pathogens	pathogen	NNS
cord-000238-om92cx5q	73	14	that	that	WDT
cord-000238-om92cx5q	73	15	lack	lack	VBP
cord-000238-om92cx5q	73	16	proteincoding	proteincode	VBG
cord-000238-om92cx5q	73	17	genes͒	genes͒	NN
cord-000238-om92cx5q	73	18	as	as	IN
cord-000238-om92cx5q	73	19	models	model	NNS
cord-000238-om92cx5q	73	20	to	to	TO
cord-000238-om92cx5q	73	21	study	study	VB
cord-000238-om92cx5q	73	22	whether	whether	IN
cord-000238-om92cx5q	73	23	elevated	elevated	JJ
cord-000238-om92cx5q	73	24	mutation	mutation	NN
cord-000238-om92cx5q	73	25	rates	rate	NNS
cord-000238-om92cx5q	73	26	favor	favor	VBP
cord-000238-om92cx5q	73	27	robust	robust	JJ
cord-000238-om92cx5q	73	28	genotypes	genotype	NNS
cord-000238-om92cx5q	73	29	.	.	.
cord-000238-om92cx5q	74	1	One	one	CD
cord-000238-om92cx5q	74	2	study	study	NN
cord-000238-om92cx5q	74	3	examined	examine	VBD
cord-000238-om92cx5q	74	4	two	two	CD
cord-000238-om92cx5q	74	5	species	specie	NNS
cord-000238-om92cx5q	74	6	of	of	IN
cord-000238-om92cx5q	74	7	viroids	viroid	NNS
cord-000238-om92cx5q	74	8	that	that	WDT
cord-000238-om92cx5q	74	9	differed	differ	VBD
cord-000238-om92cx5q	74	10	in	in	IN
cord-000238-om92cx5q	74	11	robustness	robustness	NN
cord-000238-om92cx5q	74	12	.	.	.
cord-000238-om92cx5q	75	1	13	13	CD
cord-000238-om92cx5q	76	1	The	the	DT
cord-000238-om92cx5q	76	2	robust	robust	JJ
cord-000238-om92cx5q	76	3	viroid	viroid	JJ
cord-000238-om92cx5q	76	4	species	specie	NNS
cord-000238-om92cx5q	76	5	had	have	VBD
cord-000238-om92cx5q	76	6	a	a	DT
cord-000238-om92cx5q	76	7	low	low	JJ
cord-000238-om92cx5q	76	8	reproductive	reproductive	JJ
cord-000238-om92cx5q	76	9	capacity	capacity	NN
cord-000238-om92cx5q	76	10	in	in	IN
cord-000238-om92cx5q	76	11	plants	plant	NNS
cord-000238-om92cx5q	76	12	but	but	CC
cord-000238-om92cx5q	76	13	a	a	DT
cord-000238-om92cx5q	76	14	large	large	JJ
cord-000238-om92cx5q	76	15	neutral	neutral	JJ
cord-000238-om92cx5q	76	16	neighborhood	neighborhood	NN
cord-000238-om92cx5q	76	17	of	of	IN
cord-000238-om92cx5q	76	18	mutations	mutation	NNS
cord-000238-om92cx5q	76	19	͑fraction	͑fraction	NN
cord-000238-om92cx5q	76	20	of	of	IN
cord-000238-om92cx5q	76	21	one	one	CD
cord-000238-om92cx5q	76	22	-	-	HYPH
cord-000238-om92cx5q	76	23	error	error	NN
cord-000238-om92cx5q	76	24	mutations	mutation	NNS
cord-000238-om92cx5q	76	25	that	that	WDT
cord-000238-om92cx5q	76	26	do	do	VBP
cord-000238-om92cx5q	76	27	not	not	RB
cord-000238-om92cx5q	76	28	change	change	VB
cord-000238-om92cx5q	76	29	minimum	minimum	JJ
cord-000238-om92cx5q	76	30	free	free	JJ
cord-000238-om92cx5q	76	31	energy	energy	NN
cord-000238-om92cx5q	76	32	RNAsecondary	RNAsecondary	NNP
cord-000238-om92cx5q	76	33	structure͒	structure͒	NNP
cord-000238-om92cx5q	76	34	,	,	,
cord-000238-om92cx5q	76	35	whereas	whereas	IN
cord-000238-om92cx5q	76	36	the	the	DT
cord-000238-om92cx5q	76	37	brittle	brittle	JJ
cord-000238-om92cx5q	76	38	viroid	viroid	NN
cord-000238-om92cx5q	76	39	had	have	VBD
cord-000238-om92cx5q	76	40	the	the	DT
cord-000238-om92cx5q	76	41	opposite	opposite	JJ
cord-000238-om92cx5q	76	42	combination	combination	NN
cord-000238-om92cx5q	76	43	of	of	IN
cord-000238-om92cx5q	76	44	traits	trait	NNS
cord-000238-om92cx5q	76	45	.	.	.
cord-000238-om92cx5q	77	1	It	-PRON-	PRP
cord-000238-om92cx5q	77	2	was	be	VBD
cord-000238-om92cx5q	77	3	hypothesized	hypothesize	VBN
cord-000238-om92cx5q	77	4	that	that	IN
cord-000238-om92cx5q	77	5	brittle	brittle	JJ
cord-000238-om92cx5q	77	6	viroids	viroid	NNS
cord-000238-om92cx5q	77	7	should	should	MD
cord-000238-om92cx5q	77	8	outgrow	outgrow	VB
cord-000238-om92cx5q	77	9	robust	robust	JJ
cord-000238-om92cx5q	77	10	viroids	viroid	NNS
cord-000238-om92cx5q	77	11	when	when	WRB
cord-000238-om92cx5q	77	12	coinfecting	coinfecte	VBG
cord-000238-om92cx5q	77	13	plants	plant	NNS
cord-000238-om92cx5q	77	14	under	under	IN
cord-000238-om92cx5q	77	15	ordinary	ordinary	JJ
cord-000238-om92cx5q	77	16	conditions	condition	NNS
cord-000238-om92cx5q	77	17	,	,	,
cord-000238-om92cx5q	77	18	but	but	CC
cord-000238-om92cx5q	77	19	the	the	DT
cord-000238-om92cx5q	77	20	robust	robust	JJ
cord-000238-om92cx5q	77	21	viroids	viroid	NNS
cord-000238-om92cx5q	77	22	should	should	MD
cord-000238-om92cx5q	77	23	be	be	VB
cord-000238-om92cx5q	77	24	favored	favor	VBN
cord-000238-om92cx5q	77	25	in	in	IN
cord-000238-om92cx5q	77	26	the	the	DT
cord-000238-om92cx5q	77	27	presence	presence	NN
cord-000238-om92cx5q	77	28	of	of	IN
cord-000238-om92cx5q	77	29	a	a	DT
cord-000238-om92cx5q	77	30	mutagen	mutagen	NN
cord-000238-om92cx5q	77	31	because	because	IN
cord-000238-om92cx5q	77	32	they	-PRON-	PRP
cord-000238-om92cx5q	77	33	better	well	RBR
cord-000238-om92cx5q	77	34	maintained	maintain	VBD
cord-000238-om92cx5q	77	35	phenotype	phenotype	NN
cord-000238-om92cx5q	77	36	͑proper	͑proper	.
cord-000238-om92cx5q	78	1	structure͒	structure͒	VBN
cord-000238-om92cx5q	78	2	despite	despite	IN
cord-000238-om92cx5q	78	3	mutational	mutational	JJ
cord-000238-om92cx5q	78	4	input	input	NN
cord-000238-om92cx5q	78	5	.	.	.
cord-000238-om92cx5q	79	1	As	as	IN
cord-000238-om92cx5q	79	2	predicted	predict	VBN
cord-000238-om92cx5q	79	3	,	,	,
cord-000238-om92cx5q	79	4	under	under	IN
cord-000238-om92cx5q	79	5	standard	standard	JJ
cord-000238-om92cx5q	79	6	growth	growth	NN
cord-000238-om92cx5q	79	7	conditions	condition	NNS
cord-000238-om92cx5q	79	8	in	in	IN
cord-000238-om92cx5q	79	9	host	host	NN
cord-000238-om92cx5q	79	10	plants	plant	NNS
cord-000238-om92cx5q	79	11	,	,	,
cord-000238-om92cx5q	79	12	results	result	NNS
cord-000238-om92cx5q	79	13	showed	show	VBD
cord-000238-om92cx5q	79	14	that	that	IN
cord-000238-om92cx5q	79	15	the	the	DT
cord-000238-om92cx5q	79	16	brittle	brittle	JJ
cord-000238-om92cx5q	79	17	viroid	viroid	NN
cord-000238-om92cx5q	79	18	was	be	VBD
cord-000238-om92cx5q	79	19	selectively	selectively	RB
cord-000238-om92cx5q	79	20	favored	favor	VBN
cord-000238-om92cx5q	79	21	.	.	.
cord-000238-om92cx5q	80	1	In	in	IN
cord-000238-om92cx5q	80	2	contrast	contrast	NN
cord-000238-om92cx5q	80	3	,	,	,
cord-000238-om92cx5q	80	4	when	when	WRB
cord-000238-om92cx5q	80	5	infected	infect	VBN
cord-000238-om92cx5q	80	6	plants	plant	NNS
cord-000238-om92cx5q	80	7	were	be	VBD
cord-000238-om92cx5q	80	8	subjected	subject	VBN
cord-000238-om92cx5q	80	9	to	to	IN
cord-000238-om92cx5q	80	10	irradiation	irradiation	NN
cord-000238-om92cx5q	80	11	by	by	IN
cord-000238-om92cx5q	80	12	ultraviolet	ultraviolet	NN
cord-000238-om92cx5q	80	13	C	c	NN
cord-000238-om92cx5q	80	14	͑UVC	͑uvc	NN
cord-000238-om92cx5q	80	15	;	;	:
cord-000238-om92cx5q	80	16	short	short	JJ
cord-000238-om92cx5q	80	17	wave	wave	NN
cord-000238-om92cx5q	80	18	UV	uv	NN
cord-000238-om92cx5q	80	19	light	light	NN
cord-000238-om92cx5q	80	20	of	of	IN
cord-000238-om92cx5q	80	21	wavelength	wavelength	NN
cord-000238-om92cx5q	80	22	280	280	CD
cord-000238-om92cx5q	80	23	-	-	HYPH
cord-000238-om92cx5q	80	24	100	100	CD
cord-000238-om92cx5q	80	25	nm͒	nm͒	NNP
cord-000238-om92cx5q	80	26	,	,	,
cord-000238-om92cx5q	80	27	this	this	DT
cord-000238-om92cx5q	80	28	known	know	VBN
cord-000238-om92cx5q	80	29	viroid	viroid	JJ
cord-000238-om92cx5q	80	30	mutagen	mutagen	NN
cord-000238-om92cx5q	80	31	caused	cause	VBD
cord-000238-om92cx5q	80	32	the	the	DT
cord-000238-om92cx5q	80	33	robust	robust	JJ
cord-000238-om92cx5q	80	34	viroid	viroid	NN
cord-000238-om92cx5q	80	35	to	to	TO
cord-000238-om92cx5q	80	36	be	be	VB
cord-000238-om92cx5q	80	37	favored	favor	VBN
cord-000238-om92cx5q	80	38	in	in	IN
cord-000238-om92cx5q	80	39	competition	competition	NN
cord-000238-om92cx5q	80	40	,	,	,
cord-000238-om92cx5q	80	41	because	because	IN
cord-000238-om92cx5q	80	42	it	-PRON-	PRP
cord-000238-om92cx5q	80	43	better	well	RBR
cord-000238-om92cx5q	80	44	withstood	withstand	VBD
cord-000238-om92cx5q	80	45	growth	growth	NN
cord-000238-om92cx5q	80	46	despite	despite	IN
cord-000238-om92cx5q	80	47	mutation	mutation	NN
cord-000238-om92cx5q	80	48	.	.	.
cord-000238-om92cx5q	81	1	13	13	CD
cord-000238-om92cx5q	82	1	Thus	thus	RB
cord-000238-om92cx5q	82	2	,	,	,
cord-000238-om92cx5q	82	3	this	this	DT
cord-000238-om92cx5q	82	4	empirical	empirical	JJ
cord-000238-om92cx5q	82	5	outcome	outcome	NN
cord-000238-om92cx5q	82	6	in	in	IN
cord-000238-om92cx5q	82	7	biological	biological	JJ
cord-000238-om92cx5q	82	8	populations	population	NNS
cord-000238-om92cx5q	82	9	was	be	VBD
cord-000238-om92cx5q	82	10	consistent	consistent	JJ
cord-000238-om92cx5q	82	11	with	with	IN
cord-000238-om92cx5q	82	12	the	the	DT
cord-000238-om92cx5q	82	13	earlier	early	JJR
cord-000238-om92cx5q	82	14	findings	finding	NNS
cord-000238-om92cx5q	82	15	seen	see	VBN
cord-000238-om92cx5q	82	16	in	in	IN
cord-000238-om92cx5q	82	17	artificial	artificial	JJ
cord-000238-om92cx5q	82	18	-	-	HYPH
cord-000238-om92cx5q	82	19	life	life	NN
cord-000238-om92cx5q	82	20	studies	study	NNS
cord-000238-om92cx5q	82	21	.	.	.
cord-000238-om92cx5q	83	1	9	9	CD
cord-000238-om92cx5q	84	1	A	a	DT
cord-000238-om92cx5q	84	2	second	second	JJ
cord-000238-om92cx5q	84	3	study	study	NN
cord-000238-om92cx5q	84	4	used	use	VBD
cord-000238-om92cx5q	84	5	an	an	DT
cord-000238-om92cx5q	84	6	RNA	RNA	NNP
cord-000238-om92cx5q	84	7	virus	virus	NN
cord-000238-om92cx5q	84	8	of	of	IN
cord-000238-om92cx5q	84	9	eukaryotes	eukaryote	NNS
cord-000238-om92cx5q	84	10	and	and	CC
cord-000238-om92cx5q	84	11	two	two	CD
cord-000238-om92cx5q	84	12	different	different	JJ
cord-000238-om92cx5q	84	13	mutagens	mutagen	NNS
cord-000238-om92cx5q	84	14	,	,	,
cord-000238-om92cx5q	84	15	but	but	CC
cord-000238-om92cx5q	84	16	found	find	VBD
cord-000238-om92cx5q	84	17	very	very	RB
cord-000238-om92cx5q	84	18	similar	similar	JJ
cord-000238-om92cx5q	84	19	results	result	NNS
cord-000238-om92cx5q	84	20	to	to	IN
cord-000238-om92cx5q	84	21	those	those	DT
cord-000238-om92cx5q	84	22	described	describe	VBN
cord-000238-om92cx5q	84	23	above	above	RB
cord-000238-om92cx5q	84	24	.	.	.
cord-000238-om92cx5q	85	1	27	27	CD
cord-000238-om92cx5q	86	1	Vesicular	vesicular	JJ
cord-000238-om92cx5q	86	2	stomatitis	stomatitis	NN
cord-000238-om92cx5q	86	3	virus	virus	NN
cord-000238-om92cx5q	87	1	͑VSV͒	͑VSV͒	NNP
cord-000238-om92cx5q	87	2	is	be	VBZ
cord-000238-om92cx5q	87	3	an	an	DT
cord-000238-om92cx5q	87	4	ssRNA	ssrna	NN
cord-000238-om92cx5q	87	5	virus	virus	NN
cord-000238-om92cx5q	87	6	that	that	WDT
cord-000238-om92cx5q	87	7	is	be	VBZ
cord-000238-om92cx5q	87	8	vector	vector	NN
cord-000238-om92cx5q	87	9	-	-	HYPH
cord-000238-om92cx5q	87	10	transmitted	transmit	VBN
cord-000238-om92cx5q	87	11	by	by	IN
cord-000238-om92cx5q	87	12	some	some	DT
cord-000238-om92cx5q	87	13	insects	insect	NNS
cord-000238-om92cx5q	87	14	and	and	CC
cord-000238-om92cx5q	87	15	causes	cause	VBZ
cord-000238-om92cx5q	87	16	disease	disease	NN
cord-000238-om92cx5q	87	17	in	in	IN
cord-000238-om92cx5q	87	18	certain	certain	JJ
cord-000238-om92cx5q	87	19	mammal	mammal	NN
cord-000238-om92cx5q	87	20	species	specie	NNS
cord-000238-om92cx5q	87	21	.	.	.
cord-000238-om92cx5q	88	1	28	28	CD
cord-000238-om92cx5q	88	2	,	,	,
cord-000238-om92cx5q	88	3	29	29	CD
cord-000238-om92cx5q	88	4	Two	two	CD
cord-000238-om92cx5q	88	5	diverged	diverge	VBN
cord-000238-om92cx5q	88	6	populations	population	NNS
cord-000238-om92cx5q	88	7	of	of	IN
cord-000238-om92cx5q	88	8	VSV	VSV	NNP
cord-000238-om92cx5q	88	9	were	be	VBD
cord-000238-om92cx5q	88	10	characterized	characterize	VBN
cord-000238-om92cx5q	88	11	for	for	IN
cord-000238-om92cx5q	88	12	reproductive	reproductive	JJ
cord-000238-om92cx5q	88	13	growth	growth	NN
cord-000238-om92cx5q	88	14	on	on	IN
cord-000238-om92cx5q	88	15	tissue	tissue	NN
cord-000238-om92cx5q	88	16	culture	culture	NN
cord-000238-om92cx5q	88	17	cells	cell	NNS
cord-000238-om92cx5q	88	18	,	,	,
cord-000238-om92cx5q	88	19	and	and	CC
cord-000238-om92cx5q	88	20	for	for	IN
cord-000238-om92cx5q	88	21	within	within	IN
cord-000238-om92cx5q	88	22	-	-	HYPH
cord-000238-om92cx5q	88	23	population	population	NN
cord-000238-om92cx5q	88	24	variance	variance	NN
cord-000238-om92cx5q	88	25	among	among	IN
cord-000238-om92cx5q	88	26	clones	clone	NNS
cord-000238-om92cx5q	88	27	for	for	IN
cord-000238-om92cx5q	88	28	this	this	DT
cord-000238-om92cx5q	88	29	phenotype	phenotype	NN
cord-000238-om92cx5q	88	30	;	;	:
cord-000238-om92cx5q	88	31	this	this	DT
cord-000238-om92cx5q	88	32	effort	effort	NN
cord-000238-om92cx5q	88	33	revealed	reveal	VBD
cord-000238-om92cx5q	88	34	that	that	IN
cord-000238-om92cx5q	88	35	one	one	CD
cord-000238-om92cx5q	88	36	population	population	NN
cord-000238-om92cx5q	88	37	was	be	VBD
cord-000238-om92cx5q	88	38	slow	slow	RB
cord-000238-om92cx5q	88	39	-	-	HYPH
cord-000238-om92cx5q	88	40	growing	grow	VBG
cord-000238-om92cx5q	88	41	but	but	CC
cord-000238-om92cx5q	88	42	relatively	relatively	RB
cord-000238-om92cx5q	88	43	less	less	RBR
cord-000238-om92cx5q	88	44	variable	variable	JJ
cord-000238-om92cx5q	88	45	in	in	IN
cord-000238-om92cx5q	88	46	clone	clone	NN
cord-000238-om92cx5q	88	47	phenotypes	phenotype	NNS
cord-000238-om92cx5q	88	48	͑robust͒	͑robust͒	.
cord-000238-om92cx5q	88	49	and	and	CC
cord-000238-om92cx5q	88	50	the	the	DT
cord-000238-om92cx5q	88	51	other	other	JJ
cord-000238-om92cx5q	88	52	had	have	VBD
cord-000238-om92cx5q	88	53	the	the	DT
cord-000238-om92cx5q	88	54	opposite	opposite	JJ
cord-000238-om92cx5q	88	55	characteristics	characteristic	NNS
cord-000238-om92cx5q	88	56	͑brittle͒.	͑brittle͒.	ADD
cord-000238-om92cx5q	88	57	27	27	CD
cord-000238-om92cx5q	89	1	Whereas	whereas	IN
cord-000238-om92cx5q	89	2	standard	standard	JJ
cord-000238-om92cx5q	89	3	growth	growth	NN
cord-000238-om92cx5q	89	4	conditions	condition	NNS
cord-000238-om92cx5q	89	5	allowed	allow	VBD
cord-000238-om92cx5q	89	6	the	the	DT
cord-000238-om92cx5q	89	7	faster	fast	RBR
cord-000238-om92cx5q	89	8	replicating	replicate	VBG
cord-000238-om92cx5q	89	9	brittle	brittle	JJ
cord-000238-om92cx5q	89	10	virus	virus	NN
cord-000238-om92cx5q	89	11	population	population	NN
cord-000238-om92cx5q	89	12	to	to	TO
cord-000238-om92cx5q	89	13	outcompete	outcompete	VB
cord-000238-om92cx5q	89	14	the	the	DT
cord-000238-om92cx5q	89	15	slower	slow	JJR
cord-000238-om92cx5q	89	16	replicating	replicate	VBG
cord-000238-om92cx5q	89	17	robust	robust	JJ
cord-000238-om92cx5q	89	18	population	population	NN
cord-000238-om92cx5q	89	19	,	,	,
cord-000238-om92cx5q	89	20	exposure	exposure	NN
cord-000238-om92cx5q	89	21	to	to	IN
cord-000238-om92cx5q	89	22	either	either	DT
cord-000238-om92cx5q	89	23	of	of	IN
cord-000238-om92cx5q	89	24	two	two	CD
cord-000238-om92cx5q	89	25	mutagens	mutagen	NNS
cord-000238-om92cx5q	89	26	favored	favor	VBD
cord-000238-om92cx5q	89	27	the	the	DT
cord-000238-om92cx5q	89	28	robust	robust	JJ
cord-000238-om92cx5q	89	29	variant	variant	NN
cord-000238-om92cx5q	89	30	.	.	.
cord-000238-om92cx5q	90	1	These	these	DT
cord-000238-om92cx5q	90	2	results	result	NNS
cord-000238-om92cx5q	90	3	echoed	echo	VBD
cord-000238-om92cx5q	90	4	the	the	DT
cord-000238-om92cx5q	90	5	earlier	early	JJR
cord-000238-om92cx5q	90	6	studies	study	NNS
cord-000238-om92cx5q	90	7	where	where	WRB
cord-000238-om92cx5q	90	8	competition	competition	NN
cord-000238-om92cx5q	90	9	under	under	IN
cord-000238-om92cx5q	90	10	elevated	elevated	JJ
cord-000238-om92cx5q	90	11	mutation	mutation	NN
cord-000238-om92cx5q	90	12	rates	rate	NNS
cord-000238-om92cx5q	90	13	was	be	VBD
cord-000238-om92cx5q	90	14	observed	observe	VBN
cord-000238-om92cx5q	90	15	to	to	TO
cord-000238-om92cx5q	90	16	favor	favor	VB
cord-000238-om92cx5q	90	17	robust	robust	JJ
cord-000238-om92cx5q	90	18	populations	population	NNS
cord-000238-om92cx5q	90	19	,	,	,
cord-000238-om92cx5q	90	20	even	even	RB
cord-000238-om92cx5q	90	21	though	though	IN
cord-000238-om92cx5q	90	22	robustness	robustness	NN
cord-000238-om92cx5q	90	23	was	be	VBD
cord-000238-om92cx5q	90	24	associated	associate	VBN
cord-000238-om92cx5q	90	25	with	with	IN
cord-000238-om92cx5q	90	26	reduced	reduce	VBN
cord-000238-om92cx5q	90	27	reproduction	reproduction	NN
cord-000238-om92cx5q	90	28	.	.	.
cord-000238-om92cx5q	91	1	9	9	CD
cord-000238-om92cx5q	91	2	,	,	,
cord-000238-om92cx5q	91	3	13	13	CD
cord-000238-om92cx5q	91	4	While	while	IN
cord-000238-om92cx5q	91	5	several	several	JJ
cord-000238-om92cx5q	91	6	of	of	IN
cord-000238-om92cx5q	91	7	these	these	DT
cord-000238-om92cx5q	91	8	studies	study	NNS
cord-000238-om92cx5q	91	9	have	have	VBP
cord-000238-om92cx5q	91	10	provided	provide	VBN
cord-000238-om92cx5q	91	11	evidence	evidence	NN
cord-000238-om92cx5q	91	12	for	for	IN
cord-000238-om92cx5q	91	13	extant	extant	JJ
cord-000238-om92cx5q	91	14	,	,	,
cord-000238-om92cx5q	91	15	evolvable	evolvable	JJ
cord-000238-om92cx5q	91	16	differences	difference	NNS
cord-000238-om92cx5q	91	17	in	in	IN
cord-000238-om92cx5q	91	18	robustness	robustness	NN
cord-000238-om92cx5q	91	19	,	,	,
cord-000238-om92cx5q	91	20	the	the	DT
cord-000238-om92cx5q	91	21	literature	literature	NN
cord-000238-om92cx5q	91	22	is	be	VBZ
cord-000238-om92cx5q	91	23	generally	generally	RB
cord-000238-om92cx5q	91	24	lacking	lack	VBG
cord-000238-om92cx5q	91	25	in	in	IN
cord-000238-om92cx5q	91	26	examples	example	NNS
cord-000238-om92cx5q	91	27	of	of	IN
cord-000238-om92cx5q	91	28	direct	direct	JJ
cord-000238-om92cx5q	91	29	selection	selection	NN
cord-000238-om92cx5q	91	30	for	for	IN
cord-000238-om92cx5q	91	31	robustness	robustness	NN
cord-000238-om92cx5q	91	32	in	in	IN
cord-000238-om92cx5q	91	33	biological	biological	JJ
cord-000238-om92cx5q	91	34	systems	system	NNS
cord-000238-om92cx5q	91	35	.	.	.
cord-000238-om92cx5q	92	1	In	in	IN
cord-000238-om92cx5q	92	2	an	an	DT
cord-000238-om92cx5q	92	3	effort	effort	NN
cord-000238-om92cx5q	92	4	to	to	TO
cord-000238-om92cx5q	92	5	examine	examine	VB
cord-000238-om92cx5q	92	6	direct	direct	JJ
cord-000238-om92cx5q	92	7	selection	selection	NN
cord-000238-om92cx5q	92	8	for	for	IN
cord-000238-om92cx5q	92	9	RNA	RNA	NNP
cord-000238-om92cx5q	92	10	virus	virus	NN
cord-000238-om92cx5q	92	11	resistance	resistance	NN
cord-000238-om92cx5q	92	12	to	to	IN
cord-000238-om92cx5q	92	13	UVC	UVC	NNP
cord-000238-om92cx5q	92	14	damage	damage	NN
cord-000238-om92cx5q	92	15	,	,	,
cord-000238-om92cx5q	92	16	here	here	RB
cord-000238-om92cx5q	92	17	we	-PRON-	PRP
cord-000238-om92cx5q	92	18	present	present	VBP
cord-000238-om92cx5q	92	19	new	new	JJ
cord-000238-om92cx5q	92	20	data	datum	NNS
cord-000238-om92cx5q	92	21	from	from	IN
cord-000238-om92cx5q	92	22	a	a	DT
cord-000238-om92cx5q	92	23	short	short	JJ
cord-000238-om92cx5q	92	24	-	-	HYPH
cord-000238-om92cx5q	92	25	term	term	NN
cord-000238-om92cx5q	92	26	experimental	experimental	JJ
cord-000238-om92cx5q	92	27	evolution	evolution	NN
cord-000238-om92cx5q	92	28	study	study	NN
cord-000238-om92cx5q	92	29	with	with	IN
cord-000238-om92cx5q	92	30	phage	phage	NN
cord-000238-om92cx5q	92	31	6	6	CD
cord-000238-om92cx5q	92	32	.	.	.
cord-000238-om92cx5q	93	1	These	these	DT
cord-000238-om92cx5q	93	2	results	result	NNS
cord-000238-om92cx5q	93	3	underscore	underscore	VBP
cord-000238-om92cx5q	93	4	some	some	DT
cord-000238-om92cx5q	93	5	of	of	IN
cord-000238-om92cx5q	93	6	the	the	DT
cord-000238-om92cx5q	93	7	biological	biological	JJ
cord-000238-om92cx5q	93	8	,	,	,
cord-000238-om92cx5q	93	9	methodological	methodological	JJ
cord-000238-om92cx5q	93	10	,	,	,
cord-000238-om92cx5q	93	11	and	and	CC
cord-000238-om92cx5q	93	12	conceptual	conceptual	JJ
cord-000238-om92cx5q	93	13	barriers	barrier	NNS
cord-000238-om92cx5q	93	14	to	to	IN
cord-000238-om92cx5q	93	15	observing	observe	VBG
cord-000238-om92cx5q	93	16	direct	direct	JJ
cord-000238-om92cx5q	93	17	selection	selection	NN
cord-000238-om92cx5q	93	18	for	for	IN
cord-000238-om92cx5q	93	19	robustness	robustness	NN
cord-000238-om92cx5q	93	20	in	in	IN
cord-000238-om92cx5q	93	21	RNA	RNA	NNP
cord-000238-om92cx5q	93	22	virus	virus	NN
cord-000238-om92cx5q	93	23	systems	system	NNS
cord-000238-om92cx5q	93	24	.	.	.
cord-000238-om92cx5q	94	1	UVC	UVC	NNP
cord-000238-om92cx5q	94	2	is	be	VBZ
cord-000238-om92cx5q	94	3	well	well	RB
cord-000238-om92cx5q	94	4	-	-	HYPH
cord-000238-om92cx5q	94	5	known	know	VBN
cord-000238-om92cx5q	94	6	to	to	TO
cord-000238-om92cx5q	94	7	impact	impact	VB
cord-000238-om92cx5q	94	8	RNA	rna	NN
cord-000238-om92cx5q	94	9	viruses	virus	NNS
cord-000238-om92cx5q	94	10	negatively	negatively	RB
cord-000238-om92cx5q	94	11	30	30	CD
cord-000238-om92cx5q	94	12	,	,	,
cord-000238-om92cx5q	94	13	31	31	CD
cord-000238-om92cx5q	94	14	and	and	CC
cord-000238-om92cx5q	94	15	previous	previous	JJ
cord-000238-om92cx5q	94	16	studies	study	NNS
cord-000238-om92cx5q	94	17	have	have	VBP
cord-000238-om92cx5q	94	18	directly	directly	RB
cord-000238-om92cx5q	94	19	examined	examine	VBN
cord-000238-om92cx5q	94	20	the	the	DT
cord-000238-om92cx5q	94	21	mutagenic	mutagenic	JJ
cord-000238-om92cx5q	94	22	effects	effect	NNS
cord-000238-om92cx5q	94	23	of	of	IN
cord-000238-om92cx5q	94	24	UV	uv	NN
cord-000238-om92cx5q	94	25	radiation	radiation	NN
cord-000238-om92cx5q	94	26	on	on	IN
cord-000238-om92cx5q	94	27	RNA	RNA	NNP
cord-000238-om92cx5q	94	28	genomes	genome	NNS
cord-000238-om92cx5q	94	29	.	.	.
cord-000238-om92cx5q	95	1	13	13	CD
cord-000238-om92cx5q	95	2	,	,	,
cord-000238-om92cx5q	95	3	32	32	CD
cord-000238-om92cx5q	96	1	Furthermore	furthermore	RB
cord-000238-om92cx5q	96	2	,	,	,
cord-000238-om92cx5q	96	3	evidence	evidence	NN
cord-000238-om92cx5q	96	4	from	from	IN
cord-000238-om92cx5q	96	5	the	the	DT
cord-000238-om92cx5q	96	6	biochemical	biochemical	JJ
cord-000238-om92cx5q	96	7	and	and	CC
cord-000238-om92cx5q	96	8	biophysical	biophysical	JJ
cord-000238-om92cx5q	96	9	literature	literature	NN
cord-000238-om92cx5q	96	10	suggests	suggest	VBZ
cord-000238-om92cx5q	96	11	that	that	IN
cord-000238-om92cx5q	96	12	UV	uv	NN
cord-000238-om92cx5q	96	13	radiation	radiation	NN
cord-000238-om92cx5q	96	14	can	can	MD
cord-000238-om92cx5q	96	15	interfere	interfere	VB
cord-000238-om92cx5q	96	16	with	with	IN
cord-000238-om92cx5q	96	17	RNA	RNA	NNP
cord-000238-om92cx5q	96	18	replication	replication	NN
cord-000238-om92cx5q	96	19	fidelity	fidelity	NN
cord-000238-om92cx5q	96	20	.	.	.
cord-000238-om92cx5q	97	1	[	[	-LRB-
cord-000238-om92cx5q	97	2	33	33	CD
cord-000238-om92cx5q	97	3	]	]	-RRB-
cord-000238-om92cx5q	97	4	[	[	-LRB-
cord-000238-om92cx5q	97	5	34	34	CD
cord-000238-om92cx5q	97	6	]	]	-RRB-
cord-000238-om92cx5q	97	7	[	[	-LRB-
cord-000238-om92cx5q	97	8	35	35	CD
cord-000238-om92cx5q	97	9	]	]	-RRB-
cord-000238-om92cx5q	98	1	Regardless	regardless	RB
cord-000238-om92cx5q	98	2	,	,	,
cord-000238-om92cx5q	98	3	preliminary	preliminary	JJ
cord-000238-om92cx5q	98	4	experiments	experiment	NNS
cord-000238-om92cx5q	98	5	showed	show	VBD
cord-000238-om92cx5q	98	6	that	that	IN
cord-000238-om92cx5q	98	7	UVC	uvc	NN
cord-000238-om92cx5q	98	8	exposure	exposure	NN
cord-000238-om92cx5q	98	9	for	for	IN
cord-000238-om92cx5q	98	10	periods	period	NNS
cord-000238-om92cx5q	98	11	up	up	IN
cord-000238-om92cx5q	98	12	to	to	TO
cord-000238-om92cx5q	98	13	30	30	CD
cord-000238-om92cx5q	98	14	min	min	NN
cord-000238-om92cx5q	98	15	greatly	greatly	RB
cord-000238-om92cx5q	98	16	increased	increase	VBD
cord-000238-om92cx5q	98	17	mortality	mortality	NN
cord-000238-om92cx5q	98	18	in	in	IN
cord-000238-om92cx5q	98	19	wild	wild	JJ
cord-000238-om92cx5q	98	20	type	type	NN
cord-000238-om92cx5q	98	21	phage	phage	NN
cord-000238-om92cx5q	98	22	6	6	CD
cord-000238-om92cx5q	98	23	͑Fig	͑fig	NN
cord-000238-om92cx5q	98	24	.	.	.
cord-000238-om92cx5q	99	1	2͒	2͒	NNP
cord-000238-om92cx5q	99	2	,	,	,
cord-000238-om92cx5q	99	3	indicating	indicate	VBG
cord-000238-om92cx5q	99	4	that	that	IN
cord-000238-om92cx5q	99	5	this	this	DT
cord-000238-om92cx5q	99	6	environmental	environmental	JJ
cord-000238-om92cx5q	99	7	effect	effect	NN
cord-000238-om92cx5q	99	8	should	should	MD
cord-000238-om92cx5q	99	9	produce	produce	VB
cord-000238-om92cx5q	99	10	strong	strong	JJ
cord-000238-om92cx5q	99	11	selection	selection	NN
cord-000238-om92cx5q	99	12	for	for	IN
cord-000238-om92cx5q	99	13	UVC	uvc	NN
cord-000238-om92cx5q	99	14	resistance	resistance	NN
cord-000238-om92cx5q	99	15	in	in	IN
cord-000238-om92cx5q	99	16	populations	population	NNS
cord-000238-om92cx5q	99	17	of	of	IN
cord-000238-om92cx5q	99	18	the	the	DT
cord-000238-om92cx5q	99	19	virus	virus	NN
cord-000238-om92cx5q	99	20	.	.	.
cord-000238-om92cx5q	100	1	We	-PRON-	PRP
cord-000238-om92cx5q	100	2	note	note	VBP
cord-000238-om92cx5q	100	3	that	that	IN
cord-000238-om92cx5q	100	4	identical	identical	JJ
cord-000238-om92cx5q	100	5	UVC	UVC	NNP
cord-000238-om92cx5q	100	6	exposure	exposure	NN
cord-000238-om92cx5q	100	7	was	be	VBD
cord-000238-om92cx5q	100	8	even	even	RB
cord-000238-om92cx5q	100	9	more	more	RBR
cord-000238-om92cx5q	100	10	damaging	damaging	JJ
cord-000238-om92cx5q	100	11	in	in	IN
cord-000238-om92cx5q	100	12	another	another	DT
cord-000238-om92cx5q	100	13	well	well	RB
cord-000238-om92cx5q	100	14	-	-	HYPH
cord-000238-om92cx5q	100	15	studied	study	VBN
cord-000238-om92cx5q	100	16	virus	virus	NN
cord-000238-om92cx5q	100	17	,	,	,
cord-000238-om92cx5q	100	18	the	the	DT
cord-000238-om92cx5q	100	19	ssDNA	ssdna	JJ
cord-000238-om92cx5q	100	20	phage	phage	NN
cord-000238-om92cx5q	100	21	X174	x174	FW
cord-000238-om92cx5q	100	22	͑Fig	͑Fig	NNP
cord-000238-om92cx5q	100	23	.	.	.
cord-000238-om92cx5q	101	1	2͒	2͒	LS
cord-000238-om92cx5q	101	2	;	;	:
cord-000238-om92cx5q	101	3	this	this	DT
cord-000238-om92cx5q	101	4	difference	difference	NN
cord-000238-om92cx5q	101	5	suggested	suggest	VBD
cord-000238-om92cx5q	101	6	that	that	IN
cord-000238-om92cx5q	101	7	RNA	RNA	NNP
cord-000238-om92cx5q	101	8	phage	phage	NN
cord-000238-om92cx5q	101	9	6	6	CD
cord-000238-om92cx5q	101	10	may	may	MD
cord-000238-om92cx5q	101	11	be	be	VB
cord-000238-om92cx5q	101	12	relatively	relatively	RB
cord-000238-om92cx5q	101	13	more	more	RBR
cord-000238-om92cx5q	101	14	robust	robust	JJ
cord-000238-om92cx5q	101	15	to	to	IN
cord-000238-om92cx5q	101	16	effects	effect	NNS
cord-000238-om92cx5q	101	17	of	of	IN
cord-000238-om92cx5q	101	18	UVC	UVC	NNP
cord-000238-om92cx5q	101	19	than	than	IN
cord-000238-om92cx5q	101	20	other	other	JJ
cord-000238-om92cx5q	101	21	viruses	virus	NNS
cord-000238-om92cx5q	101	22	,	,	,
cord-000238-om92cx5q	101	23	echoing	echo	VBG
cord-000238-om92cx5q	101	24	our	-PRON-	PRP$
cord-000238-om92cx5q	101	25	earlier	early	JJR
cord-000238-om92cx5q	101	26	suggestion	suggestion	NN
cord-000238-om92cx5q	101	27	that	that	IN
cord-000238-om92cx5q	101	28	the	the	DT
cord-000238-om92cx5q	101	29	virus	virus	NN
cord-000238-om92cx5q	101	30	was	be	VBD
cord-000238-om92cx5q	101	31	fairly	fairly	RB
cord-000238-om92cx5q	101	32	robust	robust	JJ
cord-000238-om92cx5q	101	33	to	to	IN
cord-000238-om92cx5q	101	34	mutation	mutation	NN
cord-000238-om92cx5q	101	35	accumulation	accumulation	NN
cord-000238-om92cx5q	101	36	.	.	.
cord-000238-om92cx5q	102	1	14	14	CD
cord-000238-om92cx5q	103	1	For	for	IN
cord-000238-om92cx5q	103	2	this	this	DT
cord-000238-om92cx5q	103	3	reason	reason	NN
cord-000238-om92cx5q	103	4	,	,	,
cord-000238-om92cx5q	103	5	experimental	experimental	JJ
cord-000238-om92cx5q	103	6	evolution	evolution	NN
cord-000238-om92cx5q	103	7	of	of	IN
cord-000238-om92cx5q	103	8	phage	phage	NN
cord-000238-om92cx5q	103	9	6	6	CD
cord-000238-om92cx5q	103	10	under	under	IN
cord-000238-om92cx5q	103	11	UVC	UVC	NNP
cord-000238-om92cx5q	103	12	exposure	exposure	NN
cord-000238-om92cx5q	103	13	may	may	MD
cord-000238-om92cx5q	103	14	provide	provide	VB
cord-000238-om92cx5q	103	15	a	a	DT
cord-000238-om92cx5q	103	16	conservative	conservative	JJ
cord-000238-om92cx5q	103	17	test	test	NN
cord-000238-om92cx5q	103	18	for	for	IN
cord-000238-om92cx5q	103	19	whether	whether	IN
cord-000238-om92cx5q	103	20	virus	virus	NN
cord-000238-om92cx5q	103	21	populations	population	NNS
cord-000238-om92cx5q	103	22	can	can	MD
cord-000238-om92cx5q	103	23	adapt	adapt	VB
cord-000238-om92cx5q	103	24	to	to	TO
cord-000238-om92cx5q	103	25	resist	resist	VB
cord-000238-om92cx5q	103	26	the	the	DT
cord-000238-om92cx5q	103	27	debilitating	debilitating	JJ
cord-000238-om92cx5q	103	28	effects	effect	NNS
cord-000238-om92cx5q	103	29	of	of	IN
cord-000238-om92cx5q	103	30	UV	uv	NN
cord-000238-om92cx5q	103	31	.	.	.
cord-000238-om92cx5q	104	1	A	a	DT
cord-000238-om92cx5q	104	2	single	single	JJ
cord-000238-om92cx5q	104	3	clone	clone	NN
cord-000238-om92cx5q	104	4	of	of	IN
cord-000238-om92cx5q	104	5	wild	wild	JJ
cord-000238-om92cx5q	104	6	type	type	NN
cord-000238-om92cx5q	104	7	phage	phage	NN
cord-000238-om92cx5q	104	8	6	6	CD
cord-000238-om92cx5q	104	9	was	be	VBD
cord-000238-om92cx5q	104	10	used	use	VBN
cord-000238-om92cx5q	104	11	to	to	TO
cord-000238-om92cx5q	104	12	found	find	VBD
cord-000238-om92cx5q	104	13	three	three	CD
cord-000238-om92cx5q	104	14	replicate	replicate	VB
cord-000238-om92cx5q	104	15	populations	population	NNS
cord-000238-om92cx5q	104	16	in	in	IN
cord-000238-om92cx5q	104	17	each	each	DT
cord-000238-om92cx5q	104	18	of	of	IN
cord-000238-om92cx5q	104	19	three	three	CD
cord-000238-om92cx5q	104	20	experimental	experimental	JJ
cord-000238-om92cx5q	104	21	treatments	treatment	NNS
cord-000238-om92cx5q	104	22	͑nine	͑nine	,
cord-000238-om92cx5q	104	23	populations	population	NNS
cord-000238-om92cx5q	104	24	total͒	total͒	NNS
cord-000238-om92cx5q	104	25	,	,	,
cord-000238-om92cx5q	104	26	where	where	WRB
cord-000238-om92cx5q	104	27	UVC	uvc	NN
cord-000238-om92cx5q	104	28	exposure	exposure	NN
cord-000238-om92cx5q	104	29	was	be	VBD
cord-000238-om92cx5q	104	30	manipulated	manipulate	VBN
cord-000238-om92cx5q	104	31	using	use	VBG
cord-000238-om92cx5q	104	32	our	-PRON-	PRP$
cord-000238-om92cx5q	104	33	published	publish	VBN
cord-000238-om92cx5q	104	34	methods	method	NNS
cord-000238-om92cx5q	104	35	.	.	.
cord-000238-om92cx5q	105	1	16	16	CD
cord-000238-om92cx5q	106	1	A	a	DT
cord-000238-om92cx5q	106	2	200	200	CD
cord-000238-om92cx5q	106	3	ml	ml	NN
cord-000238-om92cx5q	106	4	aliquot	aliquot	NN
cord-000238-om92cx5q	106	5	containing	contain	VBG
cord-000238-om92cx5q	106	6	ϳ10	ϳ10	CD
cord-000238-om92cx5q	106	7	6	6	CD
cord-000238-om92cx5q	106	8	plaque	plaque	NN
cord-000238-om92cx5q	106	9	-	-	HYPH
cord-000238-om92cx5q	106	10	forming	form	VBG
cord-000238-om92cx5q	106	11	units	unit	NNS
cord-000238-om92cx5q	106	12	͑pfu	͑pfu	CD
cord-000238-om92cx5q	106	13	;	;	,
cord-000238-om92cx5q	106	14	i.e.	i.e.	FW
cord-000238-om92cx5q	106	15	,	,	,
cord-000238-om92cx5q	106	16	viable	viable	JJ
cord-000238-om92cx5q	106	17	virus	virus	NN
cord-000238-om92cx5q	106	18	particles͒	particles͒	NN
cord-000238-om92cx5q	106	19	of	of	IN
cord-000238-om92cx5q	106	20	each	each	DT
cord-000238-om92cx5q	106	21	population	population	NN
cord-000238-om92cx5q	106	22	was	be	VBD
cord-000238-om92cx5q	106	23	suspended	suspend	VBN
cord-000238-om92cx5q	106	24	in	in	IN
cord-000238-om92cx5q	106	25	Luria	Luria	NNP
cord-000238-om92cx5q	106	26	broth	broth	NN
cord-000238-om92cx5q	106	27	culture	culture	NN
cord-000238-om92cx5q	106	28	medium	medium	NN
cord-000238-om92cx5q	106	29	in	in	IN
cord-000238-om92cx5q	106	30	the	the	DT
cord-000238-om92cx5q	106	31	absence	absence	NN
cord-000238-om92cx5q	106	32	of	of	IN
cord-000238-om92cx5q	106	33	cells	cell	NNS
cord-000238-om92cx5q	106	34	.	.	.
cord-000238-om92cx5q	107	1	Aliquots	aliquot	NNS
cord-000238-om92cx5q	107	2	were	be	VBD
cord-000238-om92cx5q	107	3	then	then	RB
cord-000238-om92cx5q	107	4	placed	place	VBN
cord-000238-om92cx5q	107	5	in	in	IN
cord-000238-om92cx5q	107	6	wells	well	NNS
cord-000238-om92cx5q	107	7	of	of	IN
cord-000238-om92cx5q	107	8	a	a	DT
cord-000238-om92cx5q	107	9	flat	flat	RB
cord-000238-om92cx5q	107	10	-	-	HYPH
cord-000238-om92cx5q	107	11	bottomed	bottomed	JJ
cord-000238-om92cx5q	107	12	polystyrene	polystyrene	NN
cord-000238-om92cx5q	107	13	96well	96well	CD
cord-000238-om92cx5q	107	14	plate	plate	NN
cord-000238-om92cx5q	107	15	.	.	.
cord-000238-om92cx5q	108	1	A	a	DT
cord-000238-om92cx5q	108	2	UV	uv	NN
cord-000238-om92cx5q	108	3	illuminator	illuminator	NN
cord-000238-om92cx5q	108	4	͑Spectroline	͑Spectroline	.
cord-000238-om92cx5q	109	1	Long	long	JJ
cord-000238-om92cx5q	109	2	Life	Life	NNP
cord-000238-om92cx5q	109	3	Filter͒	Filter͒	NNP
cord-000238-om92cx5q	109	4	was	be	VBD
cord-000238-om92cx5q	109	5	placed	place	VBN
cord-000238-om92cx5q	109	6	over	over	IN
cord-000238-om92cx5q	109	7	the	the	DT
cord-000238-om92cx5q	109	8	96-well	96-well	CD
cord-000238-om92cx5q	109	9	plate	plate	NN
cord-000238-om92cx5q	109	10	to	to	TO
cord-000238-om92cx5q	109	11	expose	expose	VB
cord-000238-om92cx5q	109	12	the	the	DT
cord-000238-om92cx5q	109	13	virus	virus	NN
cord-000238-om92cx5q	109	14	samples	sample	NNS
cord-000238-om92cx5q	109	15	to	to	IN
cord-000238-om92cx5q	109	16	UVC	UVC	NNP
cord-000238-om92cx5q	109	17	emission	emission	NN
cord-000238-om92cx5q	109	18	.	.	.
cord-000238-om92cx5q	110	1	"	"	``
cord-000238-om92cx5q	110	2	High	high	JJ
cord-000238-om92cx5q	110	3	dosage	dosage	NN
cord-000238-om92cx5q	110	4	"	"	''
cord-000238-om92cx5q	110	5	treatment	treatment	NN
cord-000238-om92cx5q	110	6	exposed	expose	VBD
cord-000238-om92cx5q	110	7	FIG	fig	NN
cord-000238-om92cx5q	110	8	.	.	.
cord-000238-om92cx5q	111	1	2	2	LS
cord-000238-om92cx5q	111	2	.	.	.
cord-000238-om92cx5q	112	1	Death	death	NN
cord-000238-om92cx5q	112	2	curves	curve	NNS
cord-000238-om92cx5q	112	3	for	for	IN
cord-000238-om92cx5q	112	4	virus	virus	NN
cord-000238-om92cx5q	112	5	strains	strain	NNS
cord-000238-om92cx5q	112	6	in	in	IN
cord-000238-om92cx5q	112	7	response	response	NN
cord-000238-om92cx5q	112	8	to	to	IN
cord-000238-om92cx5q	112	9	differing	differ	VBG
cord-000238-om92cx5q	112	10	dosages	dosage	NNS
cord-000238-om92cx5q	112	11	of	of	IN
cord-000238-om92cx5q	112	12	UVC	UVC	NNP
cord-000238-om92cx5q	112	13	exposure	exposure	NN
cord-000238-om92cx5q	112	14	.	.	.
cord-000238-om92cx5q	113	1	Wild	wild	JJ
cord-000238-om92cx5q	113	2	type	type	NN
cord-000238-om92cx5q	113	3	RNA	rna	NN
cord-000238-om92cx5q	113	4	phage	phage	NN
cord-000238-om92cx5q	113	5	6	6	CD
cord-000238-om92cx5q	114	1	͑filled	͑fille	VBD
cord-000238-om92cx5q	114	2	circles͒	circles͒	``
cord-000238-om92cx5q	114	3	better	well	JJR
cord-000238-om92cx5q	114	4	withstands	withstand	VBZ
cord-000238-om92cx5q	114	5	UVC	uvc	NN
cord-000238-om92cx5q	114	6	degradation	degradation	NN
cord-000238-om92cx5q	114	7	than	than	IN
cord-000238-om92cx5q	114	8	does	do	VBZ
cord-000238-om92cx5q	114	9	DNA	dna	NN
cord-000238-om92cx5q	114	10	phage	phage	NN
cord-000238-om92cx5q	114	11	X174	x174	XX
cord-000238-om92cx5q	114	12	͑filled	͑fille	VBN
cord-000238-om92cx5q	115	1	squares͒.	squares͒.	NNP
cord-000238-om92cx5q	115	2	A	a	DT
cord-000238-om92cx5q	115	3	phage	phage	NN
cord-000238-om92cx5q	115	4	6	6	CD
cord-000238-om92cx5q	115	5	population	population	NN
cord-000238-om92cx5q	115	6	experimentally	experimentally	RB
cord-000238-om92cx5q	115	7	evolved	evolve	VBD
cord-000238-om92cx5q	115	8	for	for	IN
cord-000238-om92cx5q	115	9	20	20	CD
cord-000238-om92cx5q	115	10	generations	generation	NNS
cord-000238-om92cx5q	115	11	under	under	IN
cord-000238-om92cx5q	115	12	2.5	2.5	CD
cord-000238-om92cx5q	115	13	min	min	NN
cord-000238-om92cx5q	115	14	UVC	UVC	NNP
cord-000238-om92cx5q	115	15	exposure	exposure	NN
cord-000238-om92cx5q	115	16	͑open	͑open	,
cord-000238-om92cx5q	115	17	circles͒	circles͒	NNP
cord-000238-om92cx5q	115	18	survives	survive	VBZ
cord-000238-om92cx5q	115	19	better	well	RBR
cord-000238-om92cx5q	115	20	than	than	IN
cord-000238-om92cx5q	115	21	its	-PRON-	PRP$
cord-000238-om92cx5q	115	22	ancestor	ancestor	NN
cord-000238-om92cx5q	115	23	,	,	,
cord-000238-om92cx5q	115	24	except	except	IN
cord-000238-om92cx5q	115	25	under	under	IN
cord-000238-om92cx5q	115	26	prolonged	prolong	VBN
cord-000238-om92cx5q	115	27	dosage	dosage	NN
cord-000238-om92cx5q	115	28	.	.	.
cord-000238-om92cx5q	116	1	In	in	IN
cord-000238-om92cx5q	116	2	contrast	contrast	NN
cord-000238-om92cx5q	116	3	,	,	,
cord-000238-om92cx5q	116	4	a	a	DT
cord-000238-om92cx5q	116	5	representative	representative	JJ
cord-000238-om92cx5q	116	6	phage	phage	NN
cord-000238-om92cx5q	116	7	6	6	CD
cord-000238-om92cx5q	116	8	control	control	NN
cord-000238-om92cx5q	116	9	population	population	NN
cord-000238-om92cx5q	116	10	͑gray	͑gray	,
cord-000238-om92cx5q	116	11	circles͒	circles͒	NNP
cord-000238-om92cx5q	116	12	evolved	evolve	VBD
cord-000238-om92cx5q	116	13	in	in	IN
cord-000238-om92cx5q	116	14	absence	absence	NN
cord-000238-om92cx5q	116	15	of	of	IN
cord-000238-om92cx5q	116	16	UVC	UVC	NNP
cord-000238-om92cx5q	116	17	exposure	exposure	NN
cord-000238-om92cx5q	116	18	presents	present	VBZ
cord-000238-om92cx5q	116	19	a	a	DT
cord-000238-om92cx5q	116	20	death	death	NN
cord-000238-om92cx5q	116	21	curve	curve	NN
cord-000238-om92cx5q	116	22	nearly	nearly	RB
cord-000238-om92cx5q	116	23	identical	identical	JJ
cord-000238-om92cx5q	116	24	to	to	IN
cord-000238-om92cx5q	116	25	the	the	DT
cord-000238-om92cx5q	116	26	ancestor	ancestor	NN
cord-000238-om92cx5q	116	27	.	.	.
cord-000238-om92cx5q	117	1	See	see	VB
cord-000238-om92cx5q	117	2	text	text	NN
cord-000238-om92cx5q	117	3	for	for	IN
cord-000238-om92cx5q	117	4	details	detail	NNS
cord-000238-om92cx5q	117	5	.	.	.
cord-000238-om92cx5q	118	1	populations	population	NNS
cord-000238-om92cx5q	118	2	to	to	IN
cord-000238-om92cx5q	118	3	UVC	UVC	NNP
cord-000238-om92cx5q	118	4	for	for	IN
cord-000238-om92cx5q	118	5	15	15	CD
cord-000238-om92cx5q	118	6	min	min	NN
cord-000238-om92cx5q	118	7	,	,	,
cord-000238-om92cx5q	118	8	"	"	``
cord-000238-om92cx5q	118	9	low	low	JJ
cord-000238-om92cx5q	118	10	dosage	dosage	NN
cord-000238-om92cx5q	118	11	"	"	''
cord-000238-om92cx5q	118	12	treatment	treatment	NN
cord-000238-om92cx5q	118	13	exposed	expose	VBD
cord-000238-om92cx5q	118	14	them	-PRON-	PRP
cord-000238-om92cx5q	118	15	for	for	IN
cord-000238-om92cx5q	118	16	2.5	2.5	CD
cord-000238-om92cx5q	118	17	min	min	NN
cord-000238-om92cx5q	118	18	,	,	,
cord-000238-om92cx5q	118	19	and	and	CC
cord-000238-om92cx5q	118	20	the	the	DT
cord-000238-om92cx5q	118	21	"	"	``
cord-000238-om92cx5q	118	22	control	control	NN
cord-000238-om92cx5q	118	23	"	"	''
cord-000238-om92cx5q	118	24	treatment	treatment	NN
cord-000238-om92cx5q	118	25	populations	population	NNS
cord-000238-om92cx5q	118	26	were	be	VBD
cord-000238-om92cx5q	118	27	never	never	RB
cord-000238-om92cx5q	118	28	exposed	expose	VBN
cord-000238-om92cx5q	118	29	to	to	IN
cord-000238-om92cx5q	118	30	UVC	UVC	NNP
cord-000238-om92cx5q	118	31	.	.	.
cord-000238-om92cx5q	119	1	Following	follow	VBG
cord-000238-om92cx5q	119	2	this	this	DT
cord-000238-om92cx5q	119	3	manipulation	manipulation	NN
cord-000238-om92cx5q	119	4	,	,	,
cord-000238-om92cx5q	119	5	each	each	DT
cord-000238-om92cx5q	119	6	population	population	NN
cord-000238-om92cx5q	119	7	was	be	VBD
cord-000238-om92cx5q	119	8	mixed	mixed	JJ
cord-000238-om92cx5q	120	1	͑1:1	͑1:1	,
cord-000238-om92cx5q	120	2	volumetric͒	volumetric͒	UH
cord-000238-om92cx5q	120	3	with	with	IN
cord-000238-om92cx5q	120	4	P.	P.	NNP
cord-000238-om92cx5q	120	5	phaseolicola	phaseolicola	NNP
cord-000238-om92cx5q	120	6	bacteria	bacteria	NNS
cord-000238-om92cx5q	121	1	͑i.e	͑i.e	NFP
cord-000238-om92cx5q	121	2	.	.	.
cord-000238-om92cx5q	122	1	,	,	,
cord-000238-om92cx5q	122	2	ϳ4	ϳ4	NNP
cord-000238-om92cx5q	122	3	ϫ	ϫ	NNP
cord-000238-om92cx5q	122	4	10	10	CD
cord-000238-om92cx5q	122	5	9	9	CD
cord-000238-om92cx5q	122	6	cells͒	cells͒	NNS
cord-000238-om92cx5q	122	7	and	and	CC
cord-000238-om92cx5q	122	8	incubated	incubate	VBN
cord-000238-om92cx5q	122	9	at	at	IN
cord-000238-om92cx5q	122	10	25	25	CD
cord-000238-om92cx5q	122	11	°	°	NN
cord-000238-om92cx5q	122	12	C	c	NN
cord-000238-om92cx5q	122	13	for	for	IN
cord-000238-om92cx5q	122	14	an	an	DT
cord-000238-om92cx5q	122	15	additional	additional	JJ
cord-000238-om92cx5q	122	16	120	120	CD
cord-000238-om92cx5q	122	17	min	min	NN
cord-000238-om92cx5q	122	18	,	,	,
cord-000238-om92cx5q	122	19	sufficient	sufficient	JJ
cord-000238-om92cx5q	122	20	time	time	NN
cord-000238-om92cx5q	122	21	for	for	IN
cord-000238-om92cx5q	122	22	at	at	RB
cord-000238-om92cx5q	122	23	least	least	RBS
cord-000238-om92cx5q	122	24	one	one	CD
cord-000238-om92cx5q	122	25	virus	virus	NN
cord-000238-om92cx5q	122	26	generation	generation	NN
cord-000238-om92cx5q	122	27	consisting	consist	VBG
cord-000238-om92cx5q	122	28	of	of	IN
cord-000238-om92cx5q	122	29	cell	cell	NN
cord-000238-om92cx5q	122	30	attachment	attachment	NN
cord-000238-om92cx5q	122	31	/	/	SYM
cord-000238-om92cx5q	122	32	entry	entry	NN
cord-000238-om92cx5q	122	33	,	,	,
cord-000238-om92cx5q	122	34	intracellular	intracellular	JJ
cord-000238-om92cx5q	122	35	replication	replication	NN
cord-000238-om92cx5q	122	36	of	of	IN
cord-000238-om92cx5q	122	37	virus	virus	NN
cord-000238-om92cx5q	122	38	progeny	progeny	NN
cord-000238-om92cx5q	122	39	,	,	,
cord-000238-om92cx5q	122	40	and	and	CC
cord-000238-om92cx5q	122	41	cell	cell	NN
cord-000238-om92cx5q	122	42	lysis	lysis	NN
cord-000238-om92cx5q	122	43	͑death͒	͑death͒	,
cord-000238-om92cx5q	122	44	that	that	WDT
cord-000238-om92cx5q	122	45	bursts	burst	VBZ
cord-000238-om92cx5q	122	46	the	the	DT
cord-000238-om92cx5q	122	47	cell	cell	NN
cord-000238-om92cx5q	122	48	to	to	TO
cord-000238-om92cx5q	122	49	liberate	liberate	VB
cord-000238-om92cx5q	122	50	offspring	offspring	NN
cord-000238-om92cx5q	122	51	.	.	.
cord-000238-om92cx5q	123	1	A	a	DT
cord-000238-om92cx5q	123	2	typical	typical	JJ
cord-000238-om92cx5q	123	3	burst	burst	NN
cord-000238-om92cx5q	123	4	in	in	IN
cord-000238-om92cx5q	123	5	phage	phage	NN
cord-000238-om92cx5q	123	6	6	6	CD
cord-000238-om92cx5q	123	7	produces	produce	VBZ
cord-000238-om92cx5q	123	8	ϳ200	ϳ200	NN
cord-000238-om92cx5q	123	9	viral	viral	JJ
cord-000238-om92cx5q	123	10	progeny	progeny	NN
cord-000238-om92cx5q	123	11	per	per	IN
cord-000238-om92cx5q	123	12	infected	infected	JJ
cord-000238-om92cx5q	123	13	cell	cell	NN
cord-000238-om92cx5q	123	14	36	36	CD
cord-000238-om92cx5q	124	1	͑we	͑we	NNP
cord-000238-om92cx5q	124	2	note	note	VBP
cord-000238-om92cx5q	124	3	that	that	IN
cord-000238-om92cx5q	124	4	the	the	DT
cord-000238-om92cx5q	124	5	host	host	NN
cord-000238-om92cx5q	124	6	bacteria	bacteria	NNS
cord-000238-om92cx5q	124	7	were	be	VBD
cord-000238-om92cx5q	124	8	never	never	RB
cord-000238-om92cx5q	124	9	exposed	expose	VBN
cord-000238-om92cx5q	124	10	to	to	IN
cord-000238-om92cx5q	124	11	UVC	UVC	NNP
cord-000238-om92cx5q	124	12	,	,	,
cord-000238-om92cx5q	124	13	eliminating	eliminate	VBG
cord-000238-om92cx5q	124	14	the	the	DT
cord-000238-om92cx5q	124	15	possibility	possibility	NN
cord-000238-om92cx5q	124	16	that	that	IN
cord-000238-om92cx5q	124	17	UVC	UVC	NNP
cord-000238-om92cx5q	124	18	negatively	negatively	RB
cord-000238-om92cx5q	124	19	impacted	impact	VBD
cord-000238-om92cx5q	124	20	cell	cell	NN
cord-000238-om92cx5q	124	21	physiology	physiology	NN
cord-000238-om92cx5q	124	22	or	or	CC
cord-000238-om92cx5q	124	23	caused	cause	VBN
cord-000238-om92cx5q	124	24	host	host	NN
cord-000238-om92cx5q	124	25	mutagenesis͒.	mutagenesis͒.	NNP
cord-000238-om92cx5q	125	1	After	after	IN
cord-000238-om92cx5q	125	2	120	120	CD
cord-000238-om92cx5q	125	3	min	min	NN
cord-000238-om92cx5q	125	4	,	,	,
cord-000238-om92cx5q	125	5	the	the	DT
cord-000238-om92cx5q	125	6	mixture	mixture	NN
cord-000238-om92cx5q	125	7	was	be	VBD
cord-000238-om92cx5q	125	8	centrifuged	centrifuge	VBN
cord-000238-om92cx5q	125	9	to	to	IN
cord-000238-om92cx5q	125	10	pellet	pellet	NN
cord-000238-om92cx5q	125	11	cells	cell	NNS
cord-000238-om92cx5q	125	12	,	,	,
cord-000238-om92cx5q	125	13	and	and	CC
cord-000238-om92cx5q	125	14	the	the	DT
cord-000238-om92cx5q	125	15	supernatant	supernatant	NN
cord-000238-om92cx5q	125	16	was	be	VBD
cord-000238-om92cx5q	125	17	filtered	filter	VBN
cord-000238-om92cx5q	125	18	to	to	TO
cord-000238-om92cx5q	125	19	harvest	harvest	VB
cord-000238-om92cx5q	125	20	a	a	DT
cord-000238-om92cx5q	125	21	cell	cell	NN
cord-000238-om92cx5q	125	22	-	-	HYPH
cord-000238-om92cx5q	125	23	free	free	JJ
cord-000238-om92cx5q	125	24	virus	virus	NN
cord-000238-om92cx5q	125	25	lysate	lysate	NN
cord-000238-om92cx5q	125	26	containing	contain	VBG
cord-000238-om92cx5q	125	27	up	up	RP
cord-000238-om92cx5q	125	28	to	to	IN
cord-000238-om92cx5q	125	29	ϳ2	ϳ2	NNP
cord-000238-om92cx5q	125	30	ϫ	ϫ	NNP
cord-000238-om92cx5q	125	31	10	10	CD
cord-000238-om92cx5q	125	32	8	8	CD
cord-000238-om92cx5q	125	33	pfu	pfu	NN
cord-000238-om92cx5q	125	34	of	of	IN
cord-000238-om92cx5q	125	35	virus	virus	NN
cord-000238-om92cx5q	125	36	progeny	progeny	NN
cord-000238-om92cx5q	125	37	.	.	.
cord-000238-om92cx5q	126	1	The	the	DT
cord-000238-om92cx5q	126	2	lysate	lysate	NN
cord-000238-om92cx5q	126	3	was	be	VBD
cord-000238-om92cx5q	126	4	then	then	RB
cord-000238-om92cx5q	126	5	stored	store	VBN
cord-000238-om92cx5q	126	6	at	at	IN
cord-000238-om92cx5q	126	7	4	4	CD
cord-000238-om92cx5q	126	8	°	°	NN
cord-000238-om92cx5q	126	9	C	c	NN
cord-000238-om92cx5q	126	10	for	for	IN
cord-000238-om92cx5q	126	11	22	22	CD
cord-000238-om92cx5q	126	12	h.	h.	NN
cord-000238-om92cx5q	127	1	The	the	DT
cord-000238-om92cx5q	127	2	lysate	lysate	NN
cord-000238-om92cx5q	127	3	was	be	VBD
cord-000238-om92cx5q	127	4	diluted	dilute	VBN
cord-000238-om92cx5q	127	5	100-fold	100-fold	CD
cord-000238-om92cx5q	127	6	and	and	CC
cord-000238-om92cx5q	127	7	used	use	VBN
cord-000238-om92cx5q	127	8	to	to	TO
cord-000238-om92cx5q	127	9	initiate	initiate	VB
cord-000238-om92cx5q	127	10	the	the	DT
cord-000238-om92cx5q	127	11	next	next	JJ
cord-000238-om92cx5q	127	12	passage	passage	NN
cord-000238-om92cx5q	127	13	where	where	WRB
cord-000238-om92cx5q	127	14	the	the	DT
cord-000238-om92cx5q	127	15	phage	phage	NN
cord-000238-om92cx5q	127	16	population	population	NN
cord-000238-om92cx5q	127	17	was	be	VBD
cord-000238-om92cx5q	127	18	again	again	RB
cord-000238-om92cx5q	127	19	subjected	subject	VBN
cord-000238-om92cx5q	127	20	to	to	IN
cord-000238-om92cx5q	127	21	treatment	treatment	NN
cord-000238-om92cx5q	127	22	or	or	CC
cord-000238-om92cx5q	127	23	control	control	NN
cord-000238-om92cx5q	127	24	conditions	condition	NNS
cord-000238-om92cx5q	127	25	,	,	,
cord-000238-om92cx5q	127	26	and	and	CC
cord-000238-om92cx5q	127	27	allowed	allow	VBN
cord-000238-om92cx5q	127	28	to	to	TO
cord-000238-om92cx5q	127	29	infect	infect	VB
cord-000238-om92cx5q	127	30	naive	naive	JJ
cord-000238-om92cx5q	127	31	bacteria	bacteria	NNS
cord-000238-om92cx5q	127	32	freshly	freshly	RB
cord-000238-om92cx5q	127	33	cultured	culture	VBN
cord-000238-om92cx5q	127	34	from	from	IN
cord-000238-om92cx5q	127	35	frozen	frozen	JJ
cord-000238-om92cx5q	127	36	stock	stock	NN
cord-000238-om92cx5q	128	1	͑i.e	͑i.e	NFP
cord-000238-om92cx5q	128	2	.	.	.
cord-000238-om92cx5q	128	3	,	,	,
cord-000238-om92cx5q	128	4	to	to	TO
cord-000238-om92cx5q	128	5	eliminate	eliminate	VB
cord-000238-om92cx5q	128	6	possibility	possibility	NN
cord-000238-om92cx5q	128	7	of	of	IN
cord-000238-om92cx5q	128	8	phage	phage	NN
cord-000238-om92cx5q	128	9	-	-	HYPH
cord-000238-om92cx5q	128	10	bacteria	bacteria	NNS
cord-000238-om92cx5q	128	11	coevo	coevo	NN
cord-000238-om92cx5q	128	12	-	-	HYPH
cord-000238-om92cx5q	128	13	lution͒.	lution͒.	NNP
cord-000238-om92cx5q	129	1	Thus	thus	RB
cord-000238-om92cx5q	129	2	,	,	,
cord-000238-om92cx5q	129	3	experimental	experimental	JJ
cord-000238-om92cx5q	129	4	populations	population	NNS
cord-000238-om92cx5q	129	5	were	be	VBD
cord-000238-om92cx5q	129	6	challenged	challenge	VBN
cord-000238-om92cx5q	129	7	to	to	TO
cord-000238-om92cx5q	129	8	produce	produce	VB
cord-000238-om92cx5q	129	9	sufficient	sufficient	JJ
cord-000238-om92cx5q	129	10	progeny	progeny	NN
cord-000238-om92cx5q	129	11	to	to	TO
cord-000238-om92cx5q	129	12	sustain	sustain	VB
cord-000238-om92cx5q	129	13	themselves	-PRON-	PRP
cord-000238-om92cx5q	129	14	in	in	IN
cord-000238-om92cx5q	129	15	the	the	DT
cord-000238-om92cx5q	129	16	face	face	NN
cord-000238-om92cx5q	129	17	of	of	IN
cord-000238-om92cx5q	129	18	the	the	DT
cord-000238-om92cx5q	129	19	daily	daily	JJ
cord-000238-om92cx5q	129	20	100-fold	100-fold	CD
cord-000238-om92cx5q	129	21	dilution	dilution	NN
cord-000238-om92cx5q	129	22	;	;	:
cord-000238-om92cx5q	129	23	UVC	UVC	NNP
cord-000238-om92cx5q	129	24	was	be	VBD
cord-000238-om92cx5q	129	25	an	an	DT
cord-000238-om92cx5q	129	26	environmental	environmental	JJ
cord-000238-om92cx5q	129	27	stressor	stressor	NN
cord-000238-om92cx5q	129	28	that	that	WDT
cord-000238-om92cx5q	129	29	could	could	MD
cord-000238-om92cx5q	129	30	reduce	reduce	VB
cord-000238-om92cx5q	129	31	the	the	DT
cord-000238-om92cx5q	129	32	likelihood	likelihood	NN
cord-000238-om92cx5q	129	33	of	of	IN
cord-000238-om92cx5q	129	34	this	this	DT
cord-000238-om92cx5q	129	35	sustainability	sustainability	NN
cord-000238-om92cx5q	129	36	unless	unless	IN
cord-000238-om92cx5q	129	37	viruses	virus	NNS
cord-000238-om92cx5q	129	38	responded	respond	VBD
cord-000238-om92cx5q	129	39	through	through	IN
cord-000238-om92cx5q	129	40	adaptation	adaptation	NN
cord-000238-om92cx5q	129	41	.	.	.
cord-000238-om92cx5q	130	1	A	a	DT
cord-000238-om92cx5q	130	2	total	total	NN
cord-000238-om92cx5q	130	3	of	of	IN
cord-000238-om92cx5q	130	4	20	20	CD
cord-000238-om92cx5q	130	5	passages	passage	NNS
cord-000238-om92cx5q	130	6	͑i.e	͑i.e	.
cord-000238-om92cx5q	130	7	.	.	.
cord-000238-om92cx5q	131	1	,	,	,
cord-000238-om92cx5q	131	2	20	20	CD
cord-000238-om92cx5q	131	3	generations͒	generations͒	NN
cord-000238-om92cx5q	131	4	occurred	occur	VBD
cord-000238-om92cx5q	131	5	in	in	IN
cord-000238-om92cx5q	131	6	the	the	DT
cord-000238-om92cx5q	131	7	short	short	JJ
cord-000238-om92cx5q	131	8	-	-	HYPH
cord-000238-om92cx5q	131	9	term	term	NN
cord-000238-om92cx5q	131	10	selection	selection	NN
cord-000238-om92cx5q	131	11	experiment	experiment	NN
cord-000238-om92cx5q	131	12	,	,	,
cord-000238-om92cx5q	131	13	and	and	CC
cord-000238-om92cx5q	131	14	samples	sample	NNS
cord-000238-om92cx5q	131	15	at	at	IN
cord-000238-om92cx5q	131	16	each	each	DT
cord-000238-om92cx5q	131	17	passage	passage	NN
cord-000238-om92cx5q	131	18	were	be	VBD
cord-000238-om92cx5q	131	19	stored	store	VBN
cord-000238-om92cx5q	131	20	at	at	IN
cord-000238-om92cx5q	131	21	−80	−80	NNP
cord-000238-om92cx5q	131	22	°	°	NN
cord-000238-om92cx5q	131	23	C	c	NN
cord-000238-om92cx5q	131	24	for	for	IN
cord-000238-om92cx5q	131	25	future	future	JJ
cord-000238-om92cx5q	131	26	analysis	analysis	NN
cord-000238-om92cx5q	131	27	.	.	.
cord-000238-om92cx5q	132	1	At	at	IN
cord-000238-om92cx5q	132	2	the	the	DT
cord-000238-om92cx5q	132	3	end	end	NN
cord-000238-om92cx5q	132	4	of	of	IN
cord-000238-om92cx5q	132	5	the	the	DT
cord-000238-om92cx5q	132	6	study	study	NN
cord-000238-om92cx5q	132	7	,	,	,
cord-000238-om92cx5q	132	8	replicated	replicate	VBD
cord-000238-om92cx5q	132	9	͑n	͑n	NNP
cord-000238-om92cx5q	132	10	=	=	SYM
cord-000238-om92cx5q	132	11	4͒	4͒	CD
cord-000238-om92cx5q	132	12	assays	assay	NNS
cord-000238-om92cx5q	132	13	were	be	VBD
cord-000238-om92cx5q	132	14	performed	perform	VBN
cord-000238-om92cx5q	132	15	to	to	TO
cord-000238-om92cx5q	132	16	gauge	gauge	VB
cord-000238-om92cx5q	132	17	whether	whether	IN
cord-000238-om92cx5q	132	18	the	the	DT
cord-000238-om92cx5q	132	19	survival	survival	NN
cord-000238-om92cx5q	132	20	of	of	IN
cord-000238-om92cx5q	132	21	treatment	treatment	NN
cord-000238-om92cx5q	132	22	populations	population	NNS
cord-000238-om92cx5q	132	23	had	have	VBD
cord-000238-om92cx5q	132	24	changed	change	VBN
cord-000238-om92cx5q	132	25	during	during	IN
cord-000238-om92cx5q	132	26	the	the	DT
cord-000238-om92cx5q	132	27	experiment	experiment	NN
cord-000238-om92cx5q	132	28	.	.	.
cord-000238-om92cx5q	133	1	Evolved	evolved	JJ
cord-000238-om92cx5q	133	2	populations	population	NNS
cord-000238-om92cx5q	133	3	were	be	VBD
cord-000238-om92cx5q	133	4	measured	measure	VBN
cord-000238-om92cx5q	133	5	for	for	IN
cord-000238-om92cx5q	133	6	frequency	frequency	NN
cord-000238-om92cx5q	133	7	of	of	IN
cord-000238-om92cx5q	133	8	surviving	survive	VBG
cord-000238-om92cx5q	133	9	virions	virion	NNS
cord-000238-om92cx5q	133	10	,	,	,
cord-000238-om92cx5q	133	11	in	in	IN
cord-000238-om92cx5q	133	12	assays	assay	NNS
cord-000238-om92cx5q	133	13	where	where	WRB
cord-000238-om92cx5q	133	14	samples	sample	NNS
cord-000238-om92cx5q	133	15	containing	contain	VBG
cord-000238-om92cx5q	133	16	ϳ10	ϳ10	CD
cord-000238-om92cx5q	133	17	6	6	CD
cord-000238-om92cx5q	133	18	pfu	pfu	NN
cord-000238-om92cx5q	133	19	of	of	IN
cord-000238-om92cx5q	133	20	virus	virus	NN
cord-000238-om92cx5q	133	21	were	be	VBD
cord-000238-om92cx5q	133	22	exposed	expose	VBN
cord-000238-om92cx5q	133	23	to	to	IN
cord-000238-om92cx5q	133	24	UVC	UVC	NNP
cord-000238-om92cx5q	133	25	for	for	IN
cord-000238-om92cx5q	133	26	six	six	CD
cord-000238-om92cx5q	133	27	different	different	JJ
cord-000238-om92cx5q	133	28	time	time	NN
cord-000238-om92cx5q	133	29	periods	period	NNS
cord-000238-om92cx5q	133	30	:	:	:
cord-000238-om92cx5q	133	31	1	1	CD
cord-000238-om92cx5q	133	32	,	,	,
cord-000238-om92cx5q	133	33	2.5	2.5	CD
cord-000238-om92cx5q	133	34	,	,	,
cord-000238-om92cx5q	133	35	5	5	CD
cord-000238-om92cx5q	133	36	,	,	,
cord-000238-om92cx5q	133	37	10	10	CD
cord-000238-om92cx5q	133	38	,	,	,
cord-000238-om92cx5q	133	39	15	15	CD
cord-000238-om92cx5q	133	40	,	,	,
cord-000238-om92cx5q	133	41	and	and	CC
cord-000238-om92cx5q	133	42	30	30	CD
cord-000238-om92cx5q	133	43	min	min	NN
cord-000238-om92cx5q	133	44	.	.	.
cord-000238-om92cx5q	134	1	Results	result	NNS
cord-000238-om92cx5q	134	2	showed	show	VBD
cord-000238-om92cx5q	134	3	that	that	IN
cord-000238-om92cx5q	134	4	after	after	IN
cord-000238-om92cx5q	134	5	20	20	CD
cord-000238-om92cx5q	134	6	passages	passage	NNS
cord-000238-om92cx5q	134	7	the	the	DT
cord-000238-om92cx5q	134	8	death	death	NN
cord-000238-om92cx5q	134	9	curves	curve	NNS
cord-000238-om92cx5q	134	10	for	for	IN
cord-000238-om92cx5q	134	11	the	the	DT
cord-000238-om92cx5q	134	12	populations	population	NNS
cord-000238-om92cx5q	134	13	in	in	IN
cord-000238-om92cx5q	134	14	the	the	DT
cord-000238-om92cx5q	134	15	control	control	NN
cord-000238-om92cx5q	134	16	treatment	treatment	NN
cord-000238-om92cx5q	134	17	were	be	VBD
cord-000238-om92cx5q	134	18	highly	highly	RB
cord-000238-om92cx5q	134	19	similar	similar	JJ
cord-000238-om92cx5q	134	20	to	to	IN
cord-000238-om92cx5q	134	21	that	that	DT
cord-000238-om92cx5q	134	22	presented	present	VBN
cord-000238-om92cx5q	134	23	by	by	IN
cord-000238-om92cx5q	134	24	the	the	DT
cord-000238-om92cx5q	134	25	wild	wild	JJ
cord-000238-om92cx5q	134	26	type	type	NN
cord-000238-om92cx5q	134	27	phage	phage	NN
cord-000238-om92cx5q	134	28	6	6	CD
cord-000238-om92cx5q	134	29	ancestor	ancestor	NN
cord-000238-om92cx5q	134	30	;	;	:
cord-000238-om92cx5q	134	31	Fig	Fig	NNP
cord-000238-om92cx5q	134	32	.	.	.
cord-000238-om92cx5q	135	1	2	2	CD
cord-000238-om92cx5q	135	2	shows	show	VBZ
cord-000238-om92cx5q	135	3	a	a	DT
cord-000238-om92cx5q	135	4	representative	representative	JJ
cord-000238-om92cx5q	135	5	outcome	outcome	NN
cord-000238-om92cx5q	135	6	for	for	IN
cord-000238-om92cx5q	135	7	one	one	CD
cord-000238-om92cx5q	135	8	of	of	IN
cord-000238-om92cx5q	135	9	the	the	DT
cord-000238-om92cx5q	135	10	control	control	NN
cord-000238-om92cx5q	135	11	populations	population	NNS
cord-000238-om92cx5q	135	12	.	.	.
cord-000238-om92cx5q	136	1	In	in	IN
cord-000238-om92cx5q	136	2	contrast	contrast	NN
cord-000238-om92cx5q	136	3	,	,	,
cord-000238-om92cx5q	136	4	we	-PRON-	PRP
cord-000238-om92cx5q	136	5	observed	observe	VBD
cord-000238-om92cx5q	136	6	that	that	IN
cord-000238-om92cx5q	136	7	all	all	DT
cord-000238-om92cx5q	136	8	three	three	CD
cord-000238-om92cx5q	136	9	lineages	lineage	NNS
cord-000238-om92cx5q	136	10	in	in	IN
cord-000238-om92cx5q	136	11	the	the	DT
cord-000238-om92cx5q	136	12	high	high	JJ
cord-000238-om92cx5q	136	13	dosage	dosage	NN
cord-000238-om92cx5q	136	14	͑15	͑15	CD
cord-000238-om92cx5q	136	15	min	min	NN
cord-000238-om92cx5q	137	1	UVC	UVC	NNP
cord-000238-om92cx5q	137	2	exposure͒	exposure͒	JJ
cord-000238-om92cx5q	137	3	treatment	treatment	NN
cord-000238-om92cx5q	137	4	went	go	VBD
cord-000238-om92cx5q	137	5	extinct	extinct	JJ
cord-000238-om92cx5q	137	6	by	by	IN
cord-000238-om92cx5q	137	7	passage	passage	NN
cord-000238-om92cx5q	137	8	10	10	CD
cord-000238-om92cx5q	137	9	of	of	IN
cord-000238-om92cx5q	137	10	the	the	DT
cord-000238-om92cx5q	137	11	experiment	experiment	NN
cord-000238-om92cx5q	137	12	͑data	͑data	.
cord-000238-om92cx5q	138	1	not	not	RB
cord-000238-om92cx5q	138	2	shown͒.	shown͒.	NNP
cord-000238-om92cx5q	139	1	These	these	DT
cord-000238-om92cx5q	139	2	data	datum	NNS
cord-000238-om92cx5q	139	3	were	be	VBD
cord-000238-om92cx5q	139	4	informative	informative	JJ
cord-000238-om92cx5q	139	5	because	because	IN
cord-000238-om92cx5q	139	6	they	-PRON-	PRP
cord-000238-om92cx5q	139	7	indicated	indicate	VBD
cord-000238-om92cx5q	139	8	that	that	IN
cord-000238-om92cx5q	139	9	the	the	DT
cord-000238-om92cx5q	139	10	strong	strong	JJ
cord-000238-om92cx5q	139	11	selection	selection	NN
cord-000238-om92cx5q	139	12	created	create	VBN
cord-000238-om92cx5q	139	13	through	through	IN
cord-000238-om92cx5q	139	14	high	high	JJ
cord-000238-om92cx5q	139	15	dosage	dosage	NN
cord-000238-om92cx5q	139	16	of	of	IN
cord-000238-om92cx5q	139	17	UVC	UVC	NNP
cord-000238-om92cx5q	139	18	exposure	exposure	NN
cord-000238-om92cx5q	139	19	was	be	VBD
cord-000238-om92cx5q	139	20	too	too	RB
cord-000238-om92cx5q	139	21	overwhelming	overwhelming	JJ
cord-000238-om92cx5q	139	22	for	for	IN
cord-000238-om92cx5q	139	23	viruses	virus	NNS
cord-000238-om92cx5q	139	24	to	to	TO
cord-000238-om92cx5q	139	25	be	be	VB
cord-000238-om92cx5q	139	26	ecologically	ecologically	RB
cord-000238-om92cx5q	139	27	sustained	sustain	VBN
cord-000238-om92cx5q	139	28	,	,	,
cord-000238-om92cx5q	139	29	and/or	and/or	CC
cord-000238-om92cx5q	139	30	to	to	TO
cord-000238-om92cx5q	139	31	experience	experience	VB
cord-000238-om92cx5q	139	32	spontaneous	spontaneous	JJ
cord-000238-om92cx5q	139	33	genetic	genetic	JJ
cord-000238-om92cx5q	139	34	variation	variation	NN
cord-000238-om92cx5q	139	35	useful	useful	JJ
cord-000238-om92cx5q	139	36	for	for	IN
cord-000238-om92cx5q	139	37	meeting	meet	VBG
cord-000238-om92cx5q	139	38	the	the	DT
cord-000238-om92cx5q	139	39	environmental	environmental	JJ
cord-000238-om92cx5q	139	40	challenge	challenge	NN
cord-000238-om92cx5q	139	41	.	.	.
cord-000238-om92cx5q	140	1	The	the	DT
cord-000238-om92cx5q	140	2	latter	latter	JJ
cord-000238-om92cx5q	140	3	outcome	outcome	NN
cord-000238-om92cx5q	140	4	clearly	clearly	RB
cord-000238-om92cx5q	140	5	demonstrated	demonstrate	VBD
cord-000238-om92cx5q	140	6	an	an	DT
cord-000238-om92cx5q	140	7	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	140	8	constraint	constraint	NN
cord-000238-om92cx5q	140	9	for	for	IN
cord-000238-om92cx5q	140	10	the	the	DT
cord-000238-om92cx5q	140	11	virus	virus	NN
cord-000238-om92cx5q	140	12	.	.	.
cord-000238-om92cx5q	141	1	Last	last	RB
cord-000238-om92cx5q	141	2	,	,	,
cord-000238-om92cx5q	141	3	all	all	DT
cord-000238-om92cx5q	141	4	of	of	IN
cord-000238-om92cx5q	141	5	the	the	DT
cord-000238-om92cx5q	141	6	evolved	evolve	VBN
cord-000238-om92cx5q	141	7	populations	population	NNS
cord-000238-om92cx5q	141	8	in	in	IN
cord-000238-om92cx5q	141	9	the	the	DT
cord-000238-om92cx5q	141	10	low	low	JJ
cord-000238-om92cx5q	141	11	dosage	dosage	NN
cord-000238-om92cx5q	141	12	͑2.5	͑2.5	NNP
cord-000238-om92cx5q	141	13	min	min	NNP
cord-000238-om92cx5q	141	14	UVC	UVC	NNP
cord-000238-om92cx5q	141	15	exposure͒	exposure͒	JJ
cord-000238-om92cx5q	141	16	treatment	treatment	NN
cord-000238-om92cx5q	141	17	were	be	VBD
cord-000238-om92cx5q	141	18	extant	extant	JJ
cord-000238-om92cx5q	141	19	by	by	IN
cord-000238-om92cx5q	141	20	end	end	NN
cord-000238-om92cx5q	141	21	of	of	IN
cord-000238-om92cx5q	141	22	the	the	DT
cord-000238-om92cx5q	141	23	study	study	NN
cord-000238-om92cx5q	141	24	.	.	.
cord-000238-om92cx5q	142	1	However	however	RB
cord-000238-om92cx5q	142	2	,	,	,
cord-000238-om92cx5q	142	3	only	only	RB
cord-000238-om92cx5q	142	4	one	one	CD
cord-000238-om92cx5q	142	5	of	of	IN
cord-000238-om92cx5q	142	6	these	these	DT
cord-000238-om92cx5q	142	7	three	three	CD
cord-000238-om92cx5q	142	8	populations	population	NNS
cord-000238-om92cx5q	142	9	exhibited	exhibit	VBD
cord-000238-om92cx5q	142	10	a	a	DT
cord-000238-om92cx5q	142	11	death	death	NN
cord-000238-om92cx5q	142	12	curve	curve	NN
cord-000238-om92cx5q	142	13	that	that	WDT
cord-000238-om92cx5q	142	14	differed	differ	VBD
cord-000238-om92cx5q	142	15	from	from	IN
cord-000238-om92cx5q	142	16	the	the	DT
cord-000238-om92cx5q	142	17	ancestor	ancestor	NN
cord-000238-om92cx5q	142	18	,	,	,
cord-000238-om92cx5q	142	19	as	as	IN
cord-000238-om92cx5q	142	20	shown	show	VBN
cord-000238-om92cx5q	142	21	in	in	IN
cord-000238-om92cx5q	142	22	Fig	Fig	NNP
cord-000238-om92cx5q	142	23	.	.	.
cord-000238-om92cx5q	143	1	2	2	LS
cord-000238-om92cx5q	143	2	.	.	.
cord-000238-om92cx5q	144	1	This	this	DT
cord-000238-om92cx5q	144	2	result	result	NN
cord-000238-om92cx5q	144	3	proved	prove	VBD
cord-000238-om92cx5q	144	4	that	that	IN
cord-000238-om92cx5q	144	5	a	a	DT
cord-000238-om92cx5q	144	6	response	response	NN
cord-000238-om92cx5q	144	7	to	to	IN
cord-000238-om92cx5q	144	8	UVC	UVC	NNP
cord-000238-om92cx5q	144	9	selection	selection	NN
cord-000238-om92cx5q	144	10	was	be	VBD
cord-000238-om92cx5q	144	11	possible	possible	JJ
cord-000238-om92cx5q	144	12	in	in	IN
cord-000238-om92cx5q	144	13	phage	phage	NN
cord-000238-om92cx5q	144	14	6	6	CD
cord-000238-om92cx5q	144	15	under	under	IN
cord-000238-om92cx5q	144	16	our	-PRON-	PRP$
cord-000238-om92cx5q	144	17	low	low	JJ
cord-000238-om92cx5q	144	18	dosage	dosage	NN
cord-000238-om92cx5q	144	19	conditions	condition	NNS
cord-000238-om92cx5q	144	20	.	.	.
cord-000238-om92cx5q	145	1	Furthermore	furthermore	RB
cord-000238-om92cx5q	145	2	,	,	,
cord-000238-om92cx5q	145	3	the	the	DT
cord-000238-om92cx5q	145	4	data	datum	NNS
cord-000238-om92cx5q	145	5	interestingly	interestingly	RB
cord-000238-om92cx5q	145	6	showed	show	VBD
cord-000238-om92cx5q	145	7	that	that	IN
cord-000238-om92cx5q	145	8	the	the	DT
cord-000238-om92cx5q	145	9	adaptation	adaptation	NN
cord-000238-om92cx5q	145	10	caused	cause	VBD
cord-000238-om92cx5q	145	11	ϳ17	ϳ17	CD
cord-000238-om92cx5q	145	12	%	%	NN
cord-000238-om92cx5q	145	13	gain	gain	NN
cord-000238-om92cx5q	145	14	in	in	IN
cord-000238-om92cx5q	145	15	survival	survival	NN
cord-000238-om92cx5q	145	16	͑on	͑on	NNP
cord-000238-om92cx5q	146	1	average͒	average͒	JJ
cord-000238-om92cx5q	146	2	relative	relative	JJ
cord-000238-om92cx5q	146	3	to	to	IN
cord-000238-om92cx5q	146	4	the	the	DT
cord-000238-om92cx5q	146	5	ancestor	ancestor	NN
cord-000238-om92cx5q	146	6	at	at	IN
cord-000238-om92cx5q	146	7	dosages	dosage	NNS
cord-000238-om92cx5q	146	8	away	away	RB
cord-000238-om92cx5q	146	9	from	from	IN
cord-000238-om92cx5q	146	10	the	the	DT
cord-000238-om92cx5q	146	11	selection	selection	NN
cord-000238-om92cx5q	146	12	challenge	challenge	NN
cord-000238-om92cx5q	146	13	of	of	IN
cord-000238-om92cx5q	146	14	2.5	2.5	CD
cord-000238-om92cx5q	146	15	min	min	NN
cord-000238-om92cx5q	146	16	͑i.e	͑i.e	NFP
cord-000238-om92cx5q	146	17	.	.	.
cord-000238-om92cx5q	147	1	,	,	,
cord-000238-om92cx5q	147	2	1	1	CD
cord-000238-om92cx5q	147	3	,	,	,
cord-000238-om92cx5q	147	4	5	5	CD
cord-000238-om92cx5q	147	5	,	,	,
cord-000238-om92cx5q	147	6	10	10	CD
cord-000238-om92cx5q	147	7	,	,	,
cord-000238-om92cx5q	147	8	and	and	CC
cord-000238-om92cx5q	147	9	15	15	CD
cord-000238-om92cx5q	147	10	min͒.	min͒.	.
cord-000238-om92cx5q	147	11	However	however	RB
cord-000238-om92cx5q	147	12	,	,	,
cord-000238-om92cx5q	147	13	this	this	DT
cord-000238-om92cx5q	147	14	response	response	NN
cord-000238-om92cx5q	147	15	on	on	IN
cord-000238-om92cx5q	147	16	the	the	DT
cord-000238-om92cx5q	147	17	part	part	NN
cord-000238-om92cx5q	147	18	of	of	IN
cord-000238-om92cx5q	147	19	the	the	DT
cord-000238-om92cx5q	147	20	one	one	CD
cord-000238-om92cx5q	147	21	lineage	lineage	NN
cord-000238-om92cx5q	147	22	was	be	VBD
cord-000238-om92cx5q	147	23	not	not	RB
cord-000238-om92cx5q	147	24	overly	overly	RB
cord-000238-om92cx5q	147	25	impressive	impressive	JJ
cord-000238-om92cx5q	147	26	,	,	,
cord-000238-om92cx5q	147	27	because	because	IN
cord-000238-om92cx5q	147	28	the	the	DT
cord-000238-om92cx5q	147	29	same	same	JJ
cord-000238-om92cx5q	147	30	50	50	CD
cord-000238-om92cx5q	147	31	%	%	NN
cord-000238-om92cx5q	147	32	mortality	mortality	NN
cord-000238-om92cx5q	147	33	as	as	IN
cord-000238-om92cx5q	147	34	the	the	DT
cord-000238-om92cx5q	147	35	ancestor	ancestor	NN
cord-000238-om92cx5q	147	36	was	be	VBD
cord-000238-om92cx5q	147	37	evident	evident	JJ
cord-000238-om92cx5q	147	38	under	under	IN
cord-000238-om92cx5q	147	39	30	30	CD
cord-000238-om92cx5q	147	40	min	min	NN
cord-000238-om92cx5q	147	41	UVC	UVC	NNP
cord-000238-om92cx5q	147	42	exposure	exposure	NN
cord-000238-om92cx5q	147	43	,	,	,
cord-000238-om92cx5q	147	44	demonstrating	demonstrate	VBG
cord-000238-om92cx5q	147	45	an	an	DT
cord-000238-om92cx5q	147	46	additional	additional	JJ
cord-000238-om92cx5q	147	47	constraint	constraint	NN
cord-000238-om92cx5q	147	48	in	in	IN
cord-000238-om92cx5q	147	49	the	the	DT
cord-000238-om92cx5q	147	50	virus	virus	NN
cord-000238-om92cx5q	147	51	even	even	RB
cord-000238-om92cx5q	147	52	though	though	IN
cord-000238-om92cx5q	147	53	an	an	DT
cord-000238-om92cx5q	147	54	adaptive	adaptive	JJ
cord-000238-om92cx5q	147	55	response	response	NN
cord-000238-om92cx5q	147	56	occurred	occur	VBD
cord-000238-om92cx5q	147	57	at	at	IN
cord-000238-om92cx5q	147	58	low	low	JJ
cord-000238-om92cx5q	147	59	dosage	dosage	NN
cord-000238-om92cx5q	147	60	͑Fig	͑fig	CD
cord-000238-om92cx5q	147	61	.	.	.
cord-000238-om92cx5q	147	62	2͒.	2͒.	CD
cord-000238-om92cx5q	148	1	Given	give	VBN
cord-000238-om92cx5q	148	2	the	the	DT
cord-000238-om92cx5q	148	3	overall	overall	JJ
cord-000238-om92cx5q	148	4	modest	modest	JJ
cord-000238-om92cx5q	148	5	response	response	NN
cord-000238-om92cx5q	148	6	in	in	IN
cord-000238-om92cx5q	148	7	phage	phage	NN
cord-000238-om92cx5q	148	8	6	6	CD
cord-000238-om92cx5q	148	9	populations	population	NNS
cord-000238-om92cx5q	148	10	subjected	subject	VBN
cord-000238-om92cx5q	148	11	to	to	IN
cord-000238-om92cx5q	148	12	strong	strong	JJ
cord-000238-om92cx5q	148	13	selection	selection	NN
cord-000238-om92cx5q	148	14	for	for	IN
cord-000238-om92cx5q	148	15	changes	change	NNS
cord-000238-om92cx5q	148	16	in	in	IN
cord-000238-om92cx5q	148	17	the	the	DT
cord-000238-om92cx5q	148	18	UVC	UVC	NNP
cord-000238-om92cx5q	148	19	survival	survival	NN
cord-000238-om92cx5q	148	20	phenotype	phenotype	NN
cord-000238-om92cx5q	148	21	,	,	,
cord-000238-om92cx5q	148	22	the	the	DT
cord-000238-om92cx5q	148	23	available	available	JJ
cord-000238-om92cx5q	148	24	evidence	evidence	NN
cord-000238-om92cx5q	148	25	strongly	strongly	RB
cord-000238-om92cx5q	148	26	suggests	suggest	VBZ
cord-000238-om92cx5q	148	27	that	that	IN
cord-000238-om92cx5q	148	28	pre	pre	JJ
cord-000238-om92cx5q	148	29	-	-	JJ
cord-000238-om92cx5q	148	30	existing	existing	JJ
cord-000238-om92cx5q	148	31	constraints	constraint	NNS
cord-000238-om92cx5q	148	32	prevent	prevent	VBP
cord-000238-om92cx5q	148	33	the	the	DT
cord-000238-om92cx5q	148	34	virus	virus	NN
cord-000238-om92cx5q	148	35	from	from	IN
cord-000238-om92cx5q	148	36	easily	easily	RB
cord-000238-om92cx5q	148	37	adapting	adapt	VBG
cord-000238-om92cx5q	148	38	.	.	.
cord-000238-om92cx5q	149	1	Thus	thus	RB
cord-000238-om92cx5q	149	2	,	,	,
cord-000238-om92cx5q	149	3	we	-PRON-	PRP
cord-000238-om92cx5q	149	4	did	do	VBD
cord-000238-om92cx5q	149	5	not	not	RB
cord-000238-om92cx5q	149	6	observe	observe	VB
cord-000238-om92cx5q	149	7	adaptive	adaptive	JJ
cord-000238-om92cx5q	149	8	increases	increase	NNS
cord-000238-om92cx5q	149	9	in	in	IN
cord-000238-om92cx5q	149	10	virus	virus	NN
cord-000238-om92cx5q	149	11	resistance	resistance	NN
cord-000238-om92cx5q	149	12	to	to	IN
cord-000238-om92cx5q	149	13	UV	uv	NN
cord-000238-om92cx5q	149	14	degradation	degradation	NN
cord-000238-om92cx5q	149	15	,	,	,
cord-000238-om92cx5q	149	16	presumably	presumably	RB
cord-000238-om92cx5q	149	17	involving	involve	VBG
cord-000238-om92cx5q	149	18	mutagenesis	mutagenesis	NN
cord-000238-om92cx5q	149	19	.	.	.
cord-000238-om92cx5q	150	1	However	however	RB
cord-000238-om92cx5q	150	2	,	,	,
cord-000238-om92cx5q	150	3	the	the	DT
cord-000238-om92cx5q	150	4	experimental	experimental	JJ
cord-000238-om92cx5q	150	5	evolution	evolution	NN
cord-000238-om92cx5q	150	6	was	be	VBD
cord-000238-om92cx5q	150	7	of	of	IN
cord-000238-om92cx5q	150	8	relatively	relatively	RB
cord-000238-om92cx5q	150	9	short	short	JJ
cord-000238-om92cx5q	150	10	duration	duration	NN
cord-000238-om92cx5q	150	11	,	,	,
cord-000238-om92cx5q	150	12	and	and	CC
cord-000238-om92cx5q	150	13	additional	additional	JJ
cord-000238-om92cx5q	150	14	selection	selection	NN
cord-000238-om92cx5q	150	15	might	may	MD
cord-000238-om92cx5q	150	16	produce	produce	VB
cord-000238-om92cx5q	150	17	adaptive	adaptive	JJ
cord-000238-om92cx5q	150	18	resistance	resistance	NN
cord-000238-om92cx5q	150	19	to	to	IN
cord-000238-om92cx5q	150	20	UVC	UVC	NNP
cord-000238-om92cx5q	150	21	damage	damage	NN
cord-000238-om92cx5q	150	22	.	.	.
cord-000238-om92cx5q	151	1	Nevertheless	nevertheless	RB
cord-000238-om92cx5q	151	2	,	,	,
cord-000238-om92cx5q	151	3	a	a	DT
cord-000238-om92cx5q	151	4	lack	lack	NN
cord-000238-om92cx5q	151	5	of	of	IN
cord-000238-om92cx5q	151	6	adaptive	adaptive	JJ
cord-000238-om92cx5q	151	7	response	response	NN
cord-000238-om92cx5q	151	8	may	may	MD
cord-000238-om92cx5q	151	9	be	be	VB
cord-000238-om92cx5q	151	10	unsurprising	unsurprising	JJ
cord-000238-om92cx5q	151	11	in	in	IN
cord-000238-om92cx5q	151	12	phage	phage	NN
cord-000238-om92cx5q	151	13	6	6	CD
cord-000238-om92cx5q	151	14	,	,	,
cord-000238-om92cx5q	151	15	because	because	IN
cord-000238-om92cx5q	151	16	elsewhere	elsewhere	RB
cord-000238-om92cx5q	151	17	we	-PRON-	PRP
cord-000238-om92cx5q	151	18	showed	show	VBD
cord-000238-om92cx5q	151	19	that	that	IN
cord-000238-om92cx5q	151	20	genetically	genetically	RB
cord-000238-om92cx5q	151	21	robust	robust	JJ
cord-000238-om92cx5q	151	22	and	and	CC
cord-000238-om92cx5q	151	23	brittle	brittle	JJ
cord-000238-om92cx5q	151	24	strains	strain	NNS
cord-000238-om92cx5q	151	25	of	of	IN
cord-000238-om92cx5q	151	26	the	the	DT
cord-000238-om92cx5q	151	27	virus	virus	NN
cord-000238-om92cx5q	151	28	generated	generate	VBN
cord-000238-om92cx5q	151	29	in	in	IN
cord-000238-om92cx5q	151	30	the	the	DT
cord-000238-om92cx5q	151	31	aforementioned	aforementioned	JJ
cord-000238-om92cx5q	151	32	MOI	MOI	NNP
cord-000238-om92cx5q	151	33	experiment	experiment	NN
cord-000238-om92cx5q	151	34	did	do	VBD
cord-000238-om92cx5q	151	35	not	not	RB
cord-000238-om92cx5q	151	36	statistically	statistically	RB
cord-000238-om92cx5q	151	37	differ	differ	VB
cord-000238-om92cx5q	151	38	when	when	WRB
cord-000238-om92cx5q	151	39	assayed	assay	VBN
cord-000238-om92cx5q	151	40	for	for	IN
cord-000238-om92cx5q	151	41	UVC	uvc	NN
cord-000238-om92cx5q	151	42	survival	survival	NN
cord-000238-om92cx5q	151	43	.	.	.
cord-000238-om92cx5q	152	1	16	16	CD
cord-000238-om92cx5q	153	1	Thus	thus	RB
cord-000238-om92cx5q	153	2	,	,	,
cord-000238-om92cx5q	153	3	neither	neither	CC
cord-000238-om92cx5q	153	4	direct	direct	JJ
cord-000238-om92cx5q	153	5	selection	selection	NN
cord-000238-om92cx5q	153	6	͑current	͑current	.
cord-000238-om92cx5q	154	1	findings͒	findings͒	JJ
cord-000238-om92cx5q	154	2	nor	nor	CC
cord-000238-om92cx5q	154	3	indirect	indirect	JJ
cord-000238-om92cx5q	154	4	selection	selection	NN
cord-000238-om92cx5q	154	5	for	for	IN
cord-000238-om92cx5q	154	6	robustness	robustness	NN
cord-000238-om92cx5q	154	7	against	against	IN
cord-000238-om92cx5q	154	8	UVC	UVC	NNP
cord-000238-om92cx5q	154	9	damage	damage	NN
cord-000238-om92cx5q	154	10	was	be	VBD
cord-000238-om92cx5q	154	11	evident	evident	JJ
cord-000238-om92cx5q	154	12	in	in	IN
cord-000238-om92cx5q	154	13	this	this	DT
cord-000238-om92cx5q	154	14	study	study	NN
cord-000238-om92cx5q	154	15	system	system	NN
cord-000238-om92cx5q	154	16	.	.	.
cord-000238-om92cx5q	155	1	These	these	DT
cord-000238-om92cx5q	155	2	observations	observation	NNS
cord-000238-om92cx5q	155	3	may	may	MD
cord-000238-om92cx5q	155	4	be	be	VB
cord-000238-om92cx5q	155	5	explained	explain	VBN
cord-000238-om92cx5q	155	6	by	by	IN
cord-000238-om92cx5q	155	7	a	a	DT
cord-000238-om92cx5q	155	8	relatively	relatively	RB
cord-000238-om92cx5q	155	9	high	high	JJ
cord-000238-om92cx5q	155	10	level	level	NN
cord-000238-om92cx5q	155	11	of	of	IN
cord-000238-om92cx5q	155	12	robustness	robustness	NN
cord-000238-om92cx5q	155	13	to	to	IN
cord-000238-om92cx5q	155	14	UV	uv	NN
cord-000238-om92cx5q	155	15	damage	damage	NN
cord-000238-om92cx5q	155	16	in	in	IN
cord-000238-om92cx5q	155	17	phage	phage	NN
cord-000238-om92cx5q	155	18	6	6	CD
cord-000238-om92cx5q	155	19	,	,	,
cord-000238-om92cx5q	155	20	which	which	WDT
cord-000238-om92cx5q	155	21	has	have	VBZ
cord-000238-om92cx5q	155	22	already	already	RB
cord-000238-om92cx5q	155	23	run	run	VBN
cord-000238-om92cx5q	155	24	the	the	DT
cord-000238-om92cx5q	155	25	gamut	gamut	NN
cord-000238-om92cx5q	155	26	of	of	IN
cord-000238-om92cx5q	155	27	selection	selection	NN
cord-000238-om92cx5q	155	28	,	,	,
cord-000238-om92cx5q	155	29	creating	create	VBG
cord-000238-om92cx5q	155	30	a	a	DT
cord-000238-om92cx5q	155	31	constraint	constraint	NN
cord-000238-om92cx5q	155	32	for	for	IN
cord-000238-om92cx5q	155	33	the	the	DT
cord-000238-om92cx5q	155	34	virus	virus	NN
cord-000238-om92cx5q	155	35	to	to	TO
cord-000238-om92cx5q	155	36	improve	improve	VB
cord-000238-om92cx5q	155	37	any	any	DT
cord-000238-om92cx5q	155	38	further	further	RB
cord-000238-om92cx5q	155	39	.	.	.
cord-000238-om92cx5q	156	1	One	one	CD
cord-000238-om92cx5q	156	2	ecological	ecological	JJ
cord-000238-om92cx5q	156	3	explanation	explanation	NN
cord-000238-om92cx5q	156	4	may	may	MD
cord-000238-om92cx5q	156	5	be	be	VB
cord-000238-om92cx5q	156	6	that	that	IN
cord-000238-om92cx5q	156	7	the	the	DT
cord-000238-om92cx5q	156	8	virus	virus	NN
cord-000238-om92cx5q	156	9	naturally	naturally	RB
cord-000238-om92cx5q	156	10	infects	infect	VBZ
cord-000238-om92cx5q	156	11	plant	plant	NN
cord-000238-om92cx5q	156	12	pathogenic	pathogenic	JJ
cord-000238-om92cx5q	156	13	bacteria	bacteria	NNS
cord-000238-om92cx5q	156	14	that	that	WDT
cord-000238-om92cx5q	156	15	colonize	colonize	VBP
cord-000238-om92cx5q	156	16	leaf	leaf	NN
cord-000238-om92cx5q	156	17	surfaces	surface	NNS
cord-000238-om92cx5q	156	18	,	,	,
cord-000238-om92cx5q	156	19	37	37	CD
cord-000238-om92cx5q	156	20	suggesting	suggest	VBG
cord-000238-om92cx5q	156	21	that	that	IN
cord-000238-om92cx5q	156	22	prior	prior	JJ
cord-000238-om92cx5q	156	23	adaptation	adaptation	NN
cord-000238-om92cx5q	156	24	to	to	TO
cord-000238-om92cx5q	156	25	resist	resist	VB
cord-000238-om92cx5q	156	26	UV	uv	NN
cord-000238-om92cx5q	156	27	damage	damage	NN
cord-000238-om92cx5q	156	28	might	may	MD
cord-000238-om92cx5q	156	29	have	have	VB
cord-000238-om92cx5q	156	30	precluded	preclude	VBN
cord-000238-om92cx5q	156	31	observations	observation	NNS
cord-000238-om92cx5q	156	32	of	of	IN
cord-000238-om92cx5q	156	33	further	further	JJ
cord-000238-om92cx5q	156	34	adaptive	adaptive	JJ
cord-000238-om92cx5q	156	35	response	response	NN
cord-000238-om92cx5q	156	36	in	in	IN
cord-000238-om92cx5q	156	37	the	the	DT
cord-000238-om92cx5q	156	38	laboratory	laboratory	NN
cord-000238-om92cx5q	156	39	.	.	.
cord-000238-om92cx5q	157	1	This	this	DT
cord-000238-om92cx5q	157	2	study	study	NN
cord-000238-om92cx5q	157	3	reveals	reveal	VBZ
cord-000238-om92cx5q	157	4	the	the	DT
cord-000238-om92cx5q	157	5	potential	potential	JJ
cord-000238-om92cx5q	157	6	pitfalls	pitfall	NNS
cord-000238-om92cx5q	157	7	to	to	IN
cord-000238-om92cx5q	157	8	overinterpreting	overinterprete	VBG
cord-000238-om92cx5q	157	9	empirical	empirical	JJ
cord-000238-om92cx5q	157	10	results	result	NNS
cord-000238-om92cx5q	157	11	in	in	IN
cord-000238-om92cx5q	157	12	the	the	DT
cord-000238-om92cx5q	157	13	attempt	attempt	NN
cord-000238-om92cx5q	157	14	to	to	TO
cord-000238-om92cx5q	157	15	study	study	VB
cord-000238-om92cx5q	157	16	robustness	robustness	NN
cord-000238-om92cx5q	157	17	.	.	.
cord-000238-om92cx5q	158	1	First	first	RB
cord-000238-om92cx5q	158	2	,	,	,
cord-000238-om92cx5q	158	3	claiming	claim	VBG
cord-000238-om92cx5q	158	4	that	that	IN
cord-000238-om92cx5q	158	5	an	an	DT
cord-000238-om92cx5q	158	6	organism	organism	NN
cord-000238-om92cx5q	158	7	has	have	VBZ
cord-000238-om92cx5q	158	8	directly	directly	RB
cord-000238-om92cx5q	158	9	evolved	evolve	VBN
cord-000238-om92cx5q	158	10	robustness	robustness	VB
cord-000238-om92cx5q	158	11	through	through	IN
cord-000238-om92cx5q	158	12	natural	natural	JJ
cord-000238-om92cx5q	158	13	selection	selection	NN
cord-000238-om92cx5q	158	14	requires	require	VBZ
cord-000238-om92cx5q	158	15	a	a	DT
cord-000238-om92cx5q	158	16	nuanced	nuanced	JJ
cord-000238-om92cx5q	158	17	understanding	understanding	NN
cord-000238-om92cx5q	158	18	of	of	IN
cord-000238-om92cx5q	158	19	how	how	WRB
cord-000238-om92cx5q	158	20	a	a	DT
cord-000238-om92cx5q	158	21	given	give	VBN
cord-000238-om92cx5q	158	22	environmental	environmental	JJ
cord-000238-om92cx5q	158	23	stressor	stressor	NN
cord-000238-om92cx5q	158	24	impacts	impact	VBZ
cord-000238-om92cx5q	158	25	an	an	DT
cord-000238-om92cx5q	158	26	evolvable	evolvable	JJ
cord-000238-om92cx5q	158	27	entity	entity	NN
cord-000238-om92cx5q	158	28	.	.	.
cord-000238-om92cx5q	159	1	Such	such	JJ
cord-000238-om92cx5q	159	2	knowledge	knowledge	NN
cord-000238-om92cx5q	159	3	can	can	MD
cord-000238-om92cx5q	159	4	be	be	VB
cord-000238-om92cx5q	159	5	dubious	dubious	JJ
cord-000238-om92cx5q	159	6	in	in	IN
cord-000238-om92cx5q	159	7	the	the	DT
cord-000238-om92cx5q	159	8	RNA	RNA	NNP
cord-000238-om92cx5q	159	9	virus	virus	NN
cord-000238-om92cx5q	159	10	context	context	NN
cord-000238-om92cx5q	159	11	,	,	,
cord-000238-om92cx5q	159	12	as	as	IN
cord-000238-om92cx5q	159	13	stressors	stressor	NNS
cord-000238-om92cx5q	159	14	such	such	JJ
cord-000238-om92cx5q	159	15	as	as	IN
cord-000238-om92cx5q	159	16	UVC	UVC	NNP
cord-000238-om92cx5q	159	17	might	may	MD
cord-000238-om92cx5q	159	18	impact	impact	VB
cord-000238-om92cx5q	159	19	RNA	RNA	NNP
cord-000238-om92cx5q	159	20	viruses	virus	NNS
cord-000238-om92cx5q	159	21	in	in	IN
cord-000238-om92cx5q	159	22	multiple	multiple	JJ
cord-000238-om92cx5q	159	23	ways	way	NNS
cord-000238-om92cx5q	159	24	.	.	.
cord-000238-om92cx5q	160	1	[	[	-LRB-
cord-000238-om92cx5q	160	2	30	30	CD
cord-000238-om92cx5q	160	3	]	]	-RRB-
cord-000238-om92cx5q	160	4	[	[	-LRB-
cord-000238-om92cx5q	160	5	31	31	CD
cord-000238-om92cx5q	160	6	]	]	-RRB-
cord-000238-om92cx5q	160	7	[	[	-LRB-
cord-000238-om92cx5q	160	8	32	32	CD
cord-000238-om92cx5q	160	9	]	]	-RRB-
cord-000238-om92cx5q	161	1	Even	even	RB
cord-000238-om92cx5q	161	2	further	far	RBR
cord-000238-om92cx5q	161	3	,	,	,
cord-000238-om92cx5q	161	4	if	if	IN
cord-000238-om92cx5q	161	5	a	a	DT
cord-000238-om92cx5q	161	6	test	test	NN
cord-000238-om92cx5q	161	7	population	population	NN
cord-000238-om92cx5q	161	8	evolves	evolve	VBZ
cord-000238-om92cx5q	161	9	an	an	DT
cord-000238-om92cx5q	161	10	adaptive	adaptive	JJ
cord-000238-om92cx5q	161	11	response	response	NN
cord-000238-om92cx5q	161	12	to	to	IN
cord-000238-om92cx5q	161	13	an	an	DT
cord-000238-om92cx5q	161	14	environmental	environmental	JJ
cord-000238-om92cx5q	161	15	challenge	challenge	NN
cord-000238-om92cx5q	161	16	,	,	,
cord-000238-om92cx5q	161	17	one	one	PRP
cord-000238-om92cx5q	161	18	has	have	VBZ
cord-000238-om92cx5q	161	19	to	to	TO
cord-000238-om92cx5q	161	20	be	be	VB
cord-000238-om92cx5q	161	21	cautious	cautious	JJ
cord-000238-om92cx5q	161	22	in	in	IN
cord-000238-om92cx5q	161	23	distinguishing	distinguish	VBG
cord-000238-om92cx5q	161	24	resistance	resistance	NN
cord-000238-om92cx5q	161	25	from	from	IN
cord-000238-om92cx5q	161	26	robustness	robustness	NN
cord-000238-om92cx5q	161	27	.	.	.
cord-000238-om92cx5q	162	1	While	while	IN
cord-000238-om92cx5q	162	2	both	both	DT
cord-000238-om92cx5q	162	3	involve	involve	VBP
cord-000238-om92cx5q	162	4	the	the	DT
cord-000238-om92cx5q	162	5	ability	ability	NN
cord-000238-om92cx5q	162	6	to	to	TO
cord-000238-om92cx5q	162	7	withstand	withstand	VB
cord-000238-om92cx5q	162	8	the	the	DT
cord-000238-om92cx5q	162	9	influence	influence	NN
cord-000238-om92cx5q	162	10	of	of	IN
cord-000238-om92cx5q	162	11	perturbations	perturbation	NNS
cord-000238-om92cx5q	162	12	,	,	,
cord-000238-om92cx5q	162	13	robustness	robustness	NN
cord-000238-om92cx5q	162	14	describes	describe	VBZ
cord-000238-om92cx5q	162	15	a	a	DT
cord-000238-om92cx5q	162	16	more	more	RBR
cord-000238-om92cx5q	162	17	generalized	generalized	JJ
cord-000238-om92cx5q	162	18	response	response	NN
cord-000238-om92cx5q	162	19	that	that	WDT
cord-000238-om92cx5q	162	20	affects	affect	VBZ
cord-000238-om92cx5q	162	21	performance	performance	NN
cord-000238-om92cx5q	162	22	in	in	IN
cord-000238-om92cx5q	162	23	multiple	multiple	JJ
cord-000238-om92cx5q	162	24	environments	environment	NNS
cord-000238-om92cx5q	162	25	1,2	1,2	CD
cord-000238-om92cx5q	162	26	and	and	CC
cord-000238-om92cx5q	162	27	evolvability	evolvability	NN
cord-000238-om92cx5q	162	28	.	.	.
cord-000238-om92cx5q	163	1	15	15	CD
cord-000238-om92cx5q	163	2	,	,	,
cord-000238-om92cx5q	163	3	16	16	CD
cord-000238-om92cx5q	163	4	 	 	_SP
cord-000238-om92cx5q	164	1	The	the	DT
cord-000238-om92cx5q	164	2	existing	exist	VBG
cord-000238-om92cx5q	164	3	empirical	empirical	JJ
cord-000238-om92cx5q	164	4	evidence	evidence	NN
cord-000238-om92cx5q	164	5	for	for	IN
cord-000238-om92cx5q	164	6	evolved	evolved	JJ
cord-000238-om92cx5q	164	7	changes	change	NNS
cord-000238-om92cx5q	164	8	and	and	CC
cord-000238-om92cx5q	164	9	selective	selective	JJ
cord-000238-om92cx5q	164	10	advantages	advantage	NNS
cord-000238-om92cx5q	164	11	in	in	IN
cord-000238-om92cx5q	164	12	robustness	robustness	NN
cord-000238-om92cx5q	164	13	reinforces	reinforce	VBZ
cord-000238-om92cx5q	164	14	the	the	DT
cord-000238-om92cx5q	164	15	importance	importance	NN
cord-000238-om92cx5q	164	16	of	of	IN
cord-000238-om92cx5q	164	17	microbial	microbial	JJ
cord-000238-om92cx5q	164	18	systems	system	NNS
cord-000238-om92cx5q	164	19	in	in	IN
cord-000238-om92cx5q	164	20	the	the	DT
cord-000238-om92cx5q	164	21	study	study	NN
cord-000238-om92cx5q	164	22	of	of	IN
cord-000238-om92cx5q	164	23	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	164	24	biology	biology	NN
cord-000238-om92cx5q	164	25	.	.	.
cord-000238-om92cx5q	165	1	But	but	CC
cord-000238-om92cx5q	165	2	later	later	RB
cord-000238-om92cx5q	165	3	work	work	NN
cord-000238-om92cx5q	165	4	examining	examine	VBG
cord-000238-om92cx5q	165	5	the	the	DT
cord-000238-om92cx5q	165	6	relationship	relationship	NN
cord-000238-om92cx5q	165	7	between	between	IN
cord-000238-om92cx5q	165	8	robustness	robustness	NN
cord-000238-om92cx5q	165	9	and	and	CC
cord-000238-om92cx5q	165	10	evolvability	evolvability	NN
cord-000238-om92cx5q	165	11	is	be	VBZ
cord-000238-om92cx5q	165	12	perhaps	perhaps	RB
cord-000238-om92cx5q	165	13	even	even	RB
cord-000238-om92cx5q	165	14	more	more	RBR
cord-000238-om92cx5q	165	15	relevant	relevant	JJ
cord-000238-om92cx5q	165	16	for	for	IN
cord-000238-om92cx5q	165	17	elucidating	elucidate	VBG
cord-000238-om92cx5q	165	18	how	how	WRB
cord-000238-om92cx5q	165	19	infectious	infectious	JJ
cord-000238-om92cx5q	165	20	diseases	disease	NNS
cord-000238-om92cx5q	165	21	evolve	evolve	VBP
cord-000238-om92cx5q	165	22	.	.	.
cord-000238-om92cx5q	166	1	On	on	IN
cord-000238-om92cx5q	166	2	the	the	DT
cord-000238-om92cx5q	166	3	one	one	CD
cord-000238-om92cx5q	166	4	hand	hand	NN
cord-000238-om92cx5q	166	5	,	,	,
cord-000238-om92cx5q	166	6	the	the	DT
cord-000238-om92cx5q	166	7	ability	ability	NN
cord-000238-om92cx5q	166	8	for	for	IN
cord-000238-om92cx5q	166	9	robustness	robustness	NN
cord-000238-om92cx5q	166	10	to	to	TO
cord-000238-om92cx5q	166	11	allow	allow	VB
cord-000238-om92cx5q	166	12	phenotypic	phenotypic	JJ
cord-000238-om92cx5q	166	13	constancy	constancy	NN
cord-000238-om92cx5q	166	14	in	in	IN
cord-000238-om92cx5q	166	15	the	the	DT
cord-000238-om92cx5q	166	16	face	face	NN
cord-000238-om92cx5q	166	17	of	of	IN
cord-000238-om92cx5q	166	18	environmental	environmental	JJ
cord-000238-om92cx5q	166	19	and	and	CC
cord-000238-om92cx5q	166	20	mutational	mutational	JJ
cord-000238-om92cx5q	166	21	perturbation	perturbation	NN
cord-000238-om92cx5q	166	22	provides	provide	VBZ
cord-000238-om92cx5q	166	23	obvious	obvious	JJ
cord-000238-om92cx5q	166	24	benefits	benefit	NNS
cord-000238-om92cx5q	166	25	,	,	,
cord-000238-om92cx5q	166	26	such	such	JJ
cord-000238-om92cx5q	166	27	as	as	IN
cord-000238-om92cx5q	166	28	reliable	reliable	JJ
cord-000238-om92cx5q	166	29	cellular	cellular	JJ
cord-000238-om92cx5q	166	30	function	function	NN
cord-000238-om92cx5q	166	31	,	,	,
cord-000238-om92cx5q	166	32	individual	individual	JJ
cord-000238-om92cx5q	166	33	development	development	NN
cord-000238-om92cx5q	166	34	,	,	,
cord-000238-om92cx5q	166	35	and	and	CC
cord-000238-om92cx5q	166	36	offspring	offspring	NN
cord-000238-om92cx5q	166	37	reproduction	reproduction	NN
cord-000238-om92cx5q	166	38	.	.	.
cord-000238-om92cx5q	167	1	However	however	RB
cord-000238-om92cx5q	167	2	,	,	,
cord-000238-om92cx5q	167	3	rigidity	rigidity	NN
cord-000238-om92cx5q	167	4	in	in	IN
cord-000238-om92cx5q	167	5	the	the	DT
cord-000238-om92cx5q	167	6	face	face	NN
cord-000238-om92cx5q	167	7	of	of	IN
cord-000238-om92cx5q	167	8	change	change	NN
cord-000238-om92cx5q	167	9	may	may	MD
cord-000238-om92cx5q	167	10	pose	pose	VB
cord-000238-om92cx5q	167	11	problems	problem	NNS
cord-000238-om92cx5q	167	12	;	;	:
cord-000238-om92cx5q	167	13	because	because	IN
cord-000238-om92cx5q	167	14	natural	natural	JJ
cord-000238-om92cx5q	167	15	selection	selection	NN
cord-000238-om92cx5q	167	16	acts	act	NNS
cord-000238-om92cx5q	167	17	on	on	IN
cord-000238-om92cx5q	167	18	phenotypic	phenotypic	JJ
cord-000238-om92cx5q	167	19	variation	variation	NN
cord-000238-om92cx5q	167	20	,	,	,
cord-000238-om92cx5q	167	21	robustness	robustness	NN
cord-000238-om92cx5q	167	22	that	that	IN
cord-000238-om92cx5q	167	23	buffers	buffer	NNS
cord-000238-om92cx5q	167	24	this	this	DT
cord-000238-om92cx5q	167	25	variation	variation	NN
cord-000238-om92cx5q	167	26	could	could	MD
cord-000238-om92cx5q	167	27	impede	impede	VB
cord-000238-om92cx5q	167	28	evolution	evolution	NN
cord-000238-om92cx5q	167	29	by	by	IN
cord-000238-om92cx5q	167	30	natural	natural	JJ
cord-000238-om92cx5q	167	31	selection	selection	NN
cord-000238-om92cx5q	167	32	.	.	.
cord-000238-om92cx5q	168	1	These	these	DT
cord-000238-om92cx5q	168	2	conflicting	conflict	VBG
cord-000238-om92cx5q	168	3	necessities	necessity	NNS
cord-000238-om92cx5q	168	4	force	force	VBP
cord-000238-om92cx5q	168	5	organisms	organism	NNS
cord-000238-om92cx5q	168	6	to	to	TO
cord-000238-om92cx5q	168	7	strike	strike	VB
cord-000238-om92cx5q	168	8	a	a	DT
cord-000238-om92cx5q	168	9	balance	balance	NN
cord-000238-om92cx5q	168	10	between	between	IN
cord-000238-om92cx5q	168	11	robustness	robustness	NN
cord-000238-om92cx5q	168	12	and	and	CC
cord-000238-om92cx5q	168	13	evolvability	evolvability	NN
cord-000238-om92cx5q	168	14	,	,	,
cord-000238-om92cx5q	168	15	the	the	DT
cord-000238-om92cx5q	168	16	capacity	capacity	NN
cord-000238-om92cx5q	168	17	to	to	TO
cord-000238-om92cx5q	168	18	adapt	adapt	VB
cord-000238-om92cx5q	168	19	.	.	.
cord-000238-om92cx5q	169	1	By	by	IN
cord-000238-om92cx5q	169	2	examining	examine	VBG
cord-000238-om92cx5q	169	3	this	this	DT
cord-000238-om92cx5q	169	4	balancing	balancing	NN
cord-000238-om92cx5q	169	5	act	act	NN
cord-000238-om92cx5q	169	6	,	,	,
cord-000238-om92cx5q	169	7	we	-PRON-	PRP
cord-000238-om92cx5q	169	8	may	may	MD
cord-000238-om92cx5q	169	9	learn	learn	VB
cord-000238-om92cx5q	169	10	whether	whether	IN
cord-000238-om92cx5q	169	11	evolvability	evolvability	NN
cord-000238-om92cx5q	169	12	can	can	MD
cord-000238-om92cx5q	169	13	itself	-PRON-	PRP
cord-000238-om92cx5q	169	14	evolve	evolve	VB
cord-000238-om92cx5q	169	15	;	;	,
cord-000238-om92cx5q	169	16	i.e.	i.e.	FW
cord-000238-om92cx5q	169	17	,	,	,
cord-000238-om92cx5q	169	18	whether	whether	IN
cord-000238-om92cx5q	169	19	natural	natural	JJ
cord-000238-om92cx5q	169	20	selection	selection	NN
cord-000238-om92cx5q	169	21	can	can	MD
cord-000238-om92cx5q	169	22	exert	exert	VB
cord-000238-om92cx5q	169	23	a	a	DT
cord-000238-om92cx5q	169	24	second	second	JJ
cord-000238-om92cx5q	169	25	-	-	HYPH
cord-000238-om92cx5q	169	26	degree	degree	NN
cord-000238-om92cx5q	169	27	effect	effect	NN
cord-000238-om92cx5q	169	28	on	on	IN
cord-000238-om92cx5q	169	29	evolution	evolution	NN
cord-000238-om92cx5q	169	30	.	.	.
cord-000238-om92cx5q	170	1	Below	below	IN
cord-000238-om92cx5q	170	2	we	-PRON-	PRP
cord-000238-om92cx5q	170	3	briefly	briefly	RB
cord-000238-om92cx5q	170	4	describe	describe	VBP
cord-000238-om92cx5q	170	5	two	two	CD
cord-000238-om92cx5q	170	6	recent	recent	JJ
cord-000238-om92cx5q	170	7	experiments	experiment	NNS
cord-000238-om92cx5q	170	8	on	on	IN
cord-000238-om92cx5q	170	9	the	the	DT
cord-000238-om92cx5q	170	10	relationship	relationship	NN
cord-000238-om92cx5q	170	11	between	between	IN
cord-000238-om92cx5q	170	12	robustness	robustness	NN
cord-000238-om92cx5q	170	13	and	and	CC
cord-000238-om92cx5q	170	14	evolvability	evolvability	NN
cord-000238-om92cx5q	170	15	.	.	.
cord-000238-om92cx5q	171	1	One	one	CD
cord-000238-om92cx5q	171	2	experiment	experiment	NN
cord-000238-om92cx5q	171	3	showed	show	VBD
cord-000238-om92cx5q	171	4	that	that	IN
cord-000238-om92cx5q	171	5	genetic	genetic	JJ
cord-000238-om92cx5q	171	6	robustness	robustness	NN
cord-000238-om92cx5q	171	7	improved	improve	VBD
cord-000238-om92cx5q	171	8	evolvability	evolvability	NN
cord-000238-om92cx5q	171	9	of	of	IN
cord-000238-om92cx5q	171	10	phage	phage	NN
cord-000238-om92cx5q	171	11	6	6	CD
cord-000238-om92cx5q	171	12	populations	population	NNS
cord-000238-om92cx5q	171	13	when	when	WRB
cord-000238-om92cx5q	171	14	heat	heat	NN
cord-000238-om92cx5q	171	15	shock	shock	NN
cord-000238-om92cx5q	171	16	was	be	VBD
cord-000238-om92cx5q	171	17	used	use	VBN
cord-000238-om92cx5q	171	18	as	as	IN
cord-000238-om92cx5q	171	19	an	an	DT
cord-000238-om92cx5q	171	20	adaptive	adaptive	JJ
cord-000238-om92cx5q	171	21	challenge	challenge	NN
cord-000238-om92cx5q	171	22	.	.	.
cord-000238-om92cx5q	172	1	15	15	CD
cord-000238-om92cx5q	172	2	Phage	Phage	NNP
cord-000238-om92cx5q	172	3	6	6	CD
cord-000238-om92cx5q	172	4	is	be	VBZ
cord-000238-om92cx5q	172	5	typically	typically	RB
cord-000238-om92cx5q	172	6	cultured	culture	VBN
cord-000238-om92cx5q	172	7	at	at	IN
cord-000238-om92cx5q	172	8	25	25	CD
cord-000238-om92cx5q	172	9	°	°	NN
cord-000238-om92cx5q	172	10	C	c	NN
cord-000238-om92cx5q	172	11	,	,	,
cord-000238-om92cx5q	172	12	and	and	CC
cord-000238-om92cx5q	172	13	exposure	exposure	NN
cord-000238-om92cx5q	172	14	to	to	IN
cord-000238-om92cx5q	172	15	45	45	CD
cord-000238-om92cx5q	172	16	°	°	NN
cord-000238-om92cx5q	172	17	C	c	NN
cord-000238-om92cx5q	172	18	heat	heat	NN
cord-000238-om92cx5q	172	19	shock	shock	NN
cord-000238-om92cx5q	172	20	for	for	IN
cord-000238-om92cx5q	172	21	as	as	RB
cord-000238-om92cx5q	172	22	little	little	JJ
cord-000238-om92cx5q	172	23	as	as	IN
cord-000238-om92cx5q	172	24	5	5	CD
cord-000238-om92cx5q	172	25	min	min	NN
cord-000238-om92cx5q	172	26	leads	lead	VBZ
cord-000238-om92cx5q	172	27	to	to	IN
cord-000238-om92cx5q	172	28	ϳ20	ϳ20	CD
cord-000238-om92cx5q	172	29	%	%	NN
cord-000238-om92cx5q	172	30	survival	survival	NN
cord-000238-om92cx5q	172	31	͑%S͒	͑%S͒	,
cord-000238-om92cx5q	172	32	in	in	IN
cord-000238-om92cx5q	172	33	populations	population	NNS
cord-000238-om92cx5q	172	34	of	of	IN
cord-000238-om92cx5q	172	35	the	the	DT
cord-000238-om92cx5q	172	36	virus	virus	NN
cord-000238-om92cx5q	172	37	.	.	.
cord-000238-om92cx5q	173	1	Robust	robust	JJ
cord-000238-om92cx5q	173	2	and	and	CC
cord-000238-om92cx5q	173	3	brittle	brittle	JJ
cord-000238-om92cx5q	173	4	clones	clone	NNS
cord-000238-om92cx5q	173	5	of	of	IN
cord-000238-om92cx5q	173	6	the	the	DT
cord-000238-om92cx5q	173	7	virus	virus	NN
cord-000238-om92cx5q	173	8	from	from	IN
cord-000238-om92cx5q	173	9	the	the	DT
cord-000238-om92cx5q	173	10	aforementioned	aforementioned	JJ
cord-000238-om92cx5q	173	11	MOI	MOI	NNP
cord-000238-om92cx5q	173	12	experiment	experiment	NN
cord-000238-om92cx5q	173	13	14	14	CD
cord-000238-om92cx5q	173	14	were	be	VBD
cord-000238-om92cx5q	173	15	used	use	VBN
cord-000238-om92cx5q	173	16	to	to	TO
cord-000238-om92cx5q	173	17	found	find	VBN
cord-000238-om92cx5q	173	18	lineages	lineage	NNS
cord-000238-om92cx5q	173	19	passaged	passage	VBN
cord-000238-om92cx5q	173	20	for	for	IN
cord-000238-om92cx5q	173	21	50	50	CD
cord-000238-om92cx5q	173	22	generations	generation	NNS
cord-000238-om92cx5q	173	23	of	of	IN
cord-000238-om92cx5q	173	24	experimental	experimental	JJ
cord-000238-om92cx5q	173	25	evolution	evolution	NN
cord-000238-om92cx5q	173	26	with	with	IN
cord-000238-om92cx5q	173	27	periodic	periodic	JJ
cord-000238-om92cx5q	173	28	͑every	͑every	JJS
cord-000238-om92cx5q	173	29	fifth	fifth	JJ
cord-000238-om92cx5q	173	30	generation͒	generation͒	HYPH
cord-000238-om92cx5q	173	31	exposure	exposure	NN
cord-000238-om92cx5q	173	32	to	to	IN
cord-000238-om92cx5q	173	33	45	45	CD
cord-000238-om92cx5q	173	34	°	°	NN
cord-000238-om92cx5q	173	35	C	c	NN
cord-000238-om92cx5q	173	36	heat	heat	NN
cord-000238-om92cx5q	173	37	shock	shock	NN
cord-000238-om92cx5q	173	38	.	.	.
cord-000238-om92cx5q	174	1	At	at	IN
cord-000238-om92cx5q	174	2	the	the	DT
cord-000238-om92cx5q	174	3	end	end	NN
cord-000238-om92cx5q	174	4	of	of	IN
cord-000238-om92cx5q	174	5	the	the	DT
cord-000238-om92cx5q	174	6	study	study	NN
cord-000238-om92cx5q	174	7	,	,	,
cord-000238-om92cx5q	174	8	we	-PRON-	PRP
cord-000238-om92cx5q	174	9	measured	measure	VBD
cord-000238-om92cx5q	174	10	mean	mean	JJ
cord-000238-om92cx5q	174	11	%	%	NN
cord-000238-om92cx5q	174	12	S	s	NN
cord-000238-om92cx5q	174	13	at	at	IN
cord-000238-om92cx5q	174	14	45	45	CD
cord-000238-om92cx5q	174	15	°	°	NN
cord-000238-om92cx5q	174	16	C	c	NN
cord-000238-om92cx5q	174	17	measured	measure	VBN
cord-000238-om92cx5q	174	18	for	for	IN
cord-000238-om92cx5q	174	19	each	each	DT
cord-000238-om92cx5q	174	20	founding	found	VBG
cord-000238-om92cx5q	174	21	clone	clone	NN
cord-000238-om92cx5q	174	22	and	and	CC
cord-000238-om92cx5q	174	23	its	-PRON-	PRP$
cord-000238-om92cx5q	174	24	derived	derive	VBN
cord-000238-om92cx5q	174	25	end	end	NN
cord-000238-om92cx5q	174	26	point	point	NN
cord-000238-om92cx5q	174	27	population	population	NN
cord-000238-om92cx5q	174	28	to	to	TO
cord-000238-om92cx5q	174	29	estimate	estimate	VB
cord-000238-om92cx5q	174	30	⌬	⌬	NNP
cord-000238-om92cx5q	174	31	%	%	NN
cord-000238-om92cx5q	174	32	S	S	NNP
cord-000238-om92cx5q	174	33	,	,	,
cord-000238-om92cx5q	174	34	the	the	DT
cord-000238-om92cx5q	174	35	change	change	NN
cord-000238-om92cx5q	174	36	in	in	IN
cord-000238-om92cx5q	174	37	percent	percent	NN
cord-000238-om92cx5q	174	38	survival	survival	NN
cord-000238-om92cx5q	174	39	after	after	IN
cord-000238-om92cx5q	174	40	heat	heat	NN
cord-000238-om92cx5q	174	41	-	-	HYPH
cord-000238-om92cx5q	174	42	shock	shock	NN
cord-000238-om92cx5q	174	43	selection	selection	NN
cord-000238-om92cx5q	174	44	.	.	.
cord-000238-om92cx5q	175	1	The	the	DT
cord-000238-om92cx5q	175	2	results	result	NNS
cord-000238-om92cx5q	175	3	showed	show	VBD
cord-000238-om92cx5q	175	4	that	that	IN
cord-000238-om92cx5q	175	5	the	the	DT
cord-000238-om92cx5q	175	6	lineages	lineage	NNS
cord-000238-om92cx5q	175	7	founded	found	VBN
cord-000238-om92cx5q	175	8	by	by	IN
cord-000238-om92cx5q	175	9	robust	robust	JJ
cord-000238-om92cx5q	175	10	genotypes	genotype	NNS
cord-000238-om92cx5q	175	11	were	be	VBD
cord-000238-om92cx5q	175	12	more	more	RBR
cord-000238-om92cx5q	175	13	evolvable	evolvable	JJ
cord-000238-om92cx5q	175	14	͑greater	͑greater	.
cord-000238-om92cx5q	175	15	⌬	⌬	NNPS
cord-000238-om92cx5q	175	16	%	%	NN
cord-000238-om92cx5q	175	17	S͒	s͒	NN
cord-000238-om92cx5q	175	18	,	,	,
cord-000238-om92cx5q	175	19	indicating	indicate	VBG
cord-000238-om92cx5q	175	20	that	that	IN
cord-000238-om92cx5q	175	21	robustness	robustness	NN
cord-000238-om92cx5q	175	22	promoted	promote	VBD
cord-000238-om92cx5q	175	23	evolvability	evolvability	NN
cord-000238-om92cx5q	175	24	in	in	IN
cord-000238-om92cx5q	175	25	phage	phage	NN
cord-000238-om92cx5q	175	26	6	6	CD
cord-000238-om92cx5q	175	27	,	,	,
cord-000238-om92cx5q	175	28	under	under	IN
cord-000238-om92cx5q	175	29	the	the	DT
cord-000238-om92cx5q	175	30	test	test	NN
cord-000238-om92cx5q	175	31	conditions	condition	NNS
cord-000238-om92cx5q	175	32	.	.	.
cord-000238-om92cx5q	176	1	The	the	DT
cord-000238-om92cx5q	176	2	explanation	explanation	NN
cord-000238-om92cx5q	176	3	was	be	VBD
cord-000238-om92cx5q	176	4	that	that	IN
cord-000238-om92cx5q	176	5	robust	robust	JJ
cord-000238-om92cx5q	176	6	genotypes	genotype	NNS
cord-000238-om92cx5q	176	7	of	of	IN
cord-000238-om92cx5q	176	8	phage	phage	NN
cord-000238-om92cx5q	176	9	6	6	CD
cord-000238-om92cx5q	176	10	may	may	MD
cord-000238-om92cx5q	176	11	have	have	VB
cord-000238-om92cx5q	176	12	proteins	protein	NNS
cord-000238-om92cx5q	176	13	that	that	WDT
cord-000238-om92cx5q	176	14	better	better	RB
cord-000238-om92cx5q	176	15	tolerate	tolerate	VBP
cord-000238-om92cx5q	176	16	mutations	mutation	NNS
cord-000238-om92cx5q	176	17	while	while	IN
cord-000238-om92cx5q	176	18	maintaining	maintain	VBG
cord-000238-om92cx5q	176	19	proper	proper	JJ
cord-000238-om92cx5q	176	20	folding	folding	NN
cord-000238-om92cx5q	176	21	especially	especially	RB
cord-000238-om92cx5q	176	22	at	at	IN
cord-000238-om92cx5q	176	23	moderate	moderate	JJ
cord-000238-om92cx5q	176	24	temperatures	temperature	NNS
cord-000238-om92cx5q	176	25	,	,	,
cord-000238-om92cx5q	176	26	16	16	CD
cord-000238-om92cx5q	176	27	similar	similar	JJ
cord-000238-om92cx5q	176	28	to	to	IN
cord-000238-om92cx5q	176	29	suggestions	suggestion	NNS
cord-000238-om92cx5q	176	30	from	from	IN
cord-000238-om92cx5q	176	31	in	in	IN
cord-000238-om92cx5q	176	32	vitro	vitro	FW
cord-000238-om92cx5q	176	33	studies	study	NNS
cord-000238-om92cx5q	176	34	where	where	WRB
cord-000238-om92cx5q	176	35	less	less	RBR
cord-000238-om92cx5q	176	36	-	-	HYPH
cord-000238-om92cx5q	176	37	sensitive	sensitive	JJ
cord-000238-om92cx5q	176	38	͑relatively	͑relatively	,
cord-000238-om92cx5q	176	39	robust͒	robust͒	JJ
cord-000238-om92cx5q	176	40	proteins	protein	NNS
cord-000238-om92cx5q	176	41	seem	seem	VBP
cord-000238-om92cx5q	176	42	more	more	RBR
cord-000238-om92cx5q	176	43	likely	likely	JJ
cord-000238-om92cx5q	176	44	to	to	TO
cord-000238-om92cx5q	176	45	maintain	maintain	VB
cord-000238-om92cx5q	176	46	their	-PRON-	PRP$
cord-000238-om92cx5q	176	47	function	function	NN
cord-000238-om92cx5q	176	48	in	in	IN
cord-000238-om92cx5q	176	49	a	a	DT
cord-000238-om92cx5q	176	50	new	new	JJ
cord-000238-om92cx5q	176	51	environment	environment	NN
cord-000238-om92cx5q	176	52	where	where	WRB
cord-000238-om92cx5q	176	53	innovation	innovation	NN
cord-000238-om92cx5q	176	54	is	be	VBZ
cord-000238-om92cx5q	176	55	needed	need	VBN
cord-000238-om92cx5q	176	56	.	.	.
cord-000238-om92cx5q	177	1	11	11	CD
cord-000238-om92cx5q	178	1	That	that	RB
cord-000238-om92cx5q	178	2	is	is	RB
cord-000238-om92cx5q	178	3	,	,	,
cord-000238-om92cx5q	178	4	despite	despite	IN
cord-000238-om92cx5q	178	5	equivalent	equivalent	JJ
cord-000238-om92cx5q	178	6	sensitivity	sensitivity	NN
cord-000238-om92cx5q	178	7	to	to	IN
cord-000238-om92cx5q	178	8	45	45	CD
cord-000238-om92cx5q	178	9	°	°	NN
cord-000238-om92cx5q	178	10	C	c	NN
cord-000238-om92cx5q	178	11	heat	heat	NN
cord-000238-om92cx5q	178	12	shock	shock	NN
cord-000238-om92cx5q	178	13	in	in	IN
cord-000238-om92cx5q	178	14	the	the	DT
cord-000238-om92cx5q	178	15	robust	robust	JJ
cord-000238-om92cx5q	178	16	and	and	CC
cord-000238-om92cx5q	178	17	brittle	brittle	JJ
cord-000238-om92cx5q	178	18	founding	founding	NN
cord-000238-om92cx5q	178	19	strains	strain	NNS
cord-000238-om92cx5q	178	20	,	,	,
cord-000238-om92cx5q	178	21	the	the	DT
cord-000238-om92cx5q	178	22	robust	robust	JJ
cord-000238-om92cx5q	178	23	viruses	virus	NNS
cord-000238-om92cx5q	178	24	may	may	MD
cord-000238-om92cx5q	178	25	have	have	VB
cord-000238-om92cx5q	178	26	proteins	protein	NNS
cord-000238-om92cx5q	178	27	that	that	WDT
cord-000238-om92cx5q	178	28	tend	tend	VBP
cord-000238-om92cx5q	178	29	to	to	TO
cord-000238-om92cx5q	178	30	be	be	VB
cord-000238-om92cx5q	178	31	capable	capable	JJ
cord-000238-om92cx5q	178	32	of	of	IN
cord-000238-om92cx5q	178	33	undergoing	undergo	VBG
cord-000238-om92cx5q	178	34	mutations	mutation	NNS
cord-000238-om92cx5q	178	35	while	while	IN
cord-000238-om92cx5q	178	36	maintaining	maintain	VBG
cord-000238-om92cx5q	178	37	their	-PRON-	PRP$
cord-000238-om92cx5q	178	38	proper	proper	JJ
cord-000238-om92cx5q	178	39	folding	folding	NN
cord-000238-om92cx5q	178	40	when	when	WRB
cord-000238-om92cx5q	178	41	45	45	CD
cord-000238-om92cx5q	178	42	°	°	NN
cord-000238-om92cx5q	178	43	C	c	NN
cord-000238-om92cx5q	178	44	constitutes	constitute	VBZ
cord-000238-om92cx5q	178	45	a	a	DT
cord-000238-om92cx5q	178	46	selective	selective	JJ
cord-000238-om92cx5q	178	47	environment	environment	NN
cord-000238-om92cx5q	178	48	.	.	.
cord-000238-om92cx5q	179	1	15	15	CD
cord-000238-om92cx5q	180	1	Whether	whether	IN
cord-000238-om92cx5q	180	2	this	this	DT
cord-000238-om92cx5q	180	3	exact	exact	JJ
cord-000238-om92cx5q	180	4	relationship	relationship	NN
cord-000238-om92cx5q	180	5	extends	extend	VBZ
cord-000238-om92cx5q	180	6	to	to	IN
cord-000238-om92cx5q	180	7	other	other	JJ
cord-000238-om92cx5q	180	8	novel	novel	JJ
cord-000238-om92cx5q	180	9	environments	environment	NNS
cord-000238-om92cx5q	180	10	has	have	VBZ
cord-000238-om92cx5q	180	11	yet	yet	RB
cord-000238-om92cx5q	180	12	to	to	TO
cord-000238-om92cx5q	180	13	be	be	VB
cord-000238-om92cx5q	180	14	explored	explore	VBN
cord-000238-om92cx5q	180	15	.	.	.
cord-000238-om92cx5q	181	1	But	but	CC
cord-000238-om92cx5q	181	2	the	the	DT
cord-000238-om92cx5q	181	3	fact	fact	NN
cord-000238-om92cx5q	181	4	that	that	IN
cord-000238-om92cx5q	181	5	a	a	DT
cord-000238-om92cx5q	181	6	positive	positive	JJ
cord-000238-om92cx5q	181	7	relationship	relationship	NN
cord-000238-om92cx5q	181	8	exists	exist	VBZ
cord-000238-om92cx5q	181	9	at	at	RB
cord-000238-om92cx5q	181	10	all	all	RB
cord-000238-om92cx5q	181	11	is	be	VBZ
cord-000238-om92cx5q	181	12	essential	essential	JJ
cord-000238-om92cx5q	181	13	for	for	IN
cord-000238-om92cx5q	181	14	tests	test	NNS
cord-000238-om92cx5q	181	15	of	of	IN
cord-000238-om92cx5q	181	16	existing	exist	VBG
cord-000238-om92cx5q	181	17	theory	theory	NN
cord-000238-om92cx5q	181	18	,	,	,
cord-000238-om92cx5q	181	19	8	8	CD
cord-000238-om92cx5q	181	20	and	and	CC
cord-000238-om92cx5q	181	21	begs	beg	VBZ
cord-000238-om92cx5q	181	22	the	the	DT
cord-000238-om92cx5q	181	23	question	question	NN
cord-000238-om92cx5q	181	24	of	of	IN
cord-000238-om92cx5q	181	25	whether	whether	IN
cord-000238-om92cx5q	181	26	the	the	DT
cord-000238-om92cx5q	181	27	observed	observed	JJ
cord-000238-om92cx5q	181	28	relationship	relationship	NN
cord-000238-om92cx5q	181	29	between	between	IN
cord-000238-om92cx5q	181	30	genetic	genetic	JJ
cord-000238-om92cx5q	181	31	robustness	robustness	NN
cord-000238-om92cx5q	181	32	and	and	CC
cord-000238-om92cx5q	181	33	evolvability	evolvability	NN
cord-000238-om92cx5q	181	34	extends	extend	VBZ
cord-000238-om92cx5q	181	35	to	to	IN
cord-000238-om92cx5q	181	36	evolution	evolution	NN
cord-000238-om92cx5q	181	37	of	of	IN
cord-000238-om92cx5q	181	38	human	human	JJ
cord-000238-om92cx5q	181	39	pathogens	pathogen	NNS
cord-000238-om92cx5q	181	40	,	,	,
cord-000238-om92cx5q	181	41	as	as	IN
cord-000238-om92cx5q	181	42	implicated	implicate	VBN
cord-000238-om92cx5q	181	43	in	in	IN
cord-000238-om92cx5q	181	44	recent	recent	JJ
cord-000238-om92cx5q	181	45	claims	claim	NNS
cord-000238-om92cx5q	181	46	of	of	IN
cord-000238-om92cx5q	181	47	evolved	evolve	VBN
cord-000238-om92cx5q	181	48	increases	increase	NNS
cord-000238-om92cx5q	181	49	in	in	IN
cord-000238-om92cx5q	181	50	genetic	genetic	JJ
cord-000238-om92cx5q	181	51	robustness	robustness	NN
cord-000238-om92cx5q	181	52	in	in	IN
cord-000238-om92cx5q	181	53	HIV	HIV	NNP
cord-000238-om92cx5q	181	54	.	.	.
cord-000238-om92cx5q	182	1	38	38	CD
cord-000238-om92cx5q	182	2	Antiviral	antiviral	JJ
cord-000238-om92cx5q	182	3	therapy	therapy	NN
cord-000238-om92cx5q	182	4	consisting	consist	VBG
cord-000238-om92cx5q	182	5	of	of	IN
cord-000238-om92cx5q	182	6	chemical	chemical	NN
cord-000238-om92cx5q	182	7	mutagenesis	mutagenesis	NN
cord-000238-om92cx5q	182	8	that	that	WDT
cord-000238-om92cx5q	182	9	induces	induce	VBZ
cord-000238-om92cx5q	182	10	an	an	DT
cord-000238-om92cx5q	182	11	insurmountable	insurmountable	JJ
cord-000238-om92cx5q	182	12	mutational	mutational	JJ
cord-000238-om92cx5q	182	13	load	load	NN
cord-000238-om92cx5q	182	14	seems	seem	VBZ
cord-000238-om92cx5q	182	15	promising	promising	JJ
cord-000238-om92cx5q	182	16	for	for	IN
cord-000238-om92cx5q	182	17	treatment	treatment	NN
cord-000238-om92cx5q	182	18	of	of	IN
cord-000238-om92cx5q	182	19	RNA	RNA	NNP
cord-000238-om92cx5q	182	20	virus	virus	NN
cord-000238-om92cx5q	182	21	infections	infection	NNS
cord-000238-om92cx5q	182	22	.	.	.
cord-000238-om92cx5q	183	1	[	[	-LRB-
cord-000238-om92cx5q	183	2	39	39	CD
cord-000238-om92cx5q	183	3	]	]	-RRB-
cord-000238-om92cx5q	183	4	[	[	-LRB-
cord-000238-om92cx5q	183	5	40	40	CD
cord-000238-om92cx5q	183	6	]	]	-RRB-
cord-000238-om92cx5q	183	7	[	[	-LRB-
cord-000238-om92cx5q	183	8	41	41	CD
cord-000238-om92cx5q	183	9	]	]	-RRB-
cord-000238-om92cx5q	184	1	But	but	CC
cord-000238-om92cx5q	184	2	such	such	JJ
cord-000238-om92cx5q	184	3	measures	measure	NNS
cord-000238-om92cx5q	184	4	may	may	MD
cord-000238-om92cx5q	184	5	select	select	VB
cord-000238-om92cx5q	184	6	for	for	IN
cord-000238-om92cx5q	184	7	RNA	RNA	NNP
cord-000238-om92cx5q	184	8	viruses	virus	NNS
cord-000238-om92cx5q	184	9	to	to	TO
cord-000238-om92cx5q	184	10	evolve	evolve	VB
cord-000238-om92cx5q	184	11	altered	alter	VBN
cord-000238-om92cx5q	184	12	polymerases	polymerase	NNS
cord-000238-om92cx5q	184	13	with	with	IN
cord-000238-om92cx5q	184	14	improved	improve	VBN
cord-000238-om92cx5q	184	15	replication	replication	NN
cord-000238-om92cx5q	184	16	fidelity	fidelity	NN
cord-000238-om92cx5q	184	17	that	that	WDT
cord-000238-om92cx5q	184	18	reduces	reduce	VBZ
cord-000238-om92cx5q	184	19	genomic	genomic	JJ
cord-000238-om92cx5q	184	20	mutation	mutation	NN
cord-000238-om92cx5q	184	21	rates	rate	NNS
cord-000238-om92cx5q	184	22	.	.	.
cord-000238-om92cx5q	185	1	42	42	CD
cord-000238-om92cx5q	186	1	Alternatively	alternatively	RB
cord-000238-om92cx5q	186	2	,	,	,
cord-000238-om92cx5q	186	3	viruses	virus	NNS
cord-000238-om92cx5q	186	4	may	may	MD
cord-000238-om92cx5q	186	5	be	be	VB
cord-000238-om92cx5q	186	6	selected	select	VBN
cord-000238-om92cx5q	186	7	to	to	TO
cord-000238-om92cx5q	186	8	evolve	evolve	VB
cord-000238-om92cx5q	186	9	mechanisms	mechanism	NNS
cord-000238-om92cx5q	186	10	of	of	IN
cord-000238-om92cx5q	186	11	genetic	genetic	JJ
cord-000238-om92cx5q	186	12	robustness	robustness	NN
cord-000238-om92cx5q	186	13	where	where	WRB
cord-000238-om92cx5q	186	14	high	high	JJ
cord-000238-om92cx5q	186	15	mutation	mutation	NN
cord-000238-om92cx5q	186	16	rates	rate	NNS
cord-000238-om92cx5q	186	17	are	be	VBP
cord-000238-om92cx5q	186	18	preserved	preserve	VBN
cord-000238-om92cx5q	186	19	but	but	CC
cord-000238-om92cx5q	186	20	phenotypic	phenotypic	JJ
cord-000238-om92cx5q	186	21	effects	effect	NNS
cord-000238-om92cx5q	186	22	of	of	IN
cord-000238-om92cx5q	186	23	the	the	DT
cord-000238-om92cx5q	186	24	mutagen	mutagen	NN
cord-000238-om92cx5q	186	25	are	be	VBP
cord-000238-om92cx5q	186	26	buffered	buffer	VBN
cord-000238-om92cx5q	186	27	.	.	.
cord-000238-om92cx5q	187	1	This	this	DT
cord-000238-om92cx5q	187	2	outcome	outcome	NN
cord-000238-om92cx5q	187	3	is	be	VBZ
cord-000238-om92cx5q	187	4	perhaps	perhaps	RB
cord-000238-om92cx5q	187	5	unlikely	unlikely	JJ
cord-000238-om92cx5q	187	6	given	give	VBN
cord-000238-om92cx5q	187	7	the	the	DT
cord-000238-om92cx5q	187	8	empirical	empirical	JJ
cord-000238-om92cx5q	187	9	data	datum	NNS
cord-000238-om92cx5q	187	10	thus	thus	RB
cord-000238-om92cx5q	187	11	far	far	RB
cord-000238-om92cx5q	187	12	.	.	.
cord-000238-om92cx5q	188	1	43	43	CD
cord-000238-om92cx5q	189	1	However	however	RB
cord-000238-om92cx5q	189	2	,	,	,
cord-000238-om92cx5q	189	3	further	further	JJ
cord-000238-om92cx5q	189	4	data	datum	NNS
cord-000238-om92cx5q	189	5	involving	involve	VBG
cord-000238-om92cx5q	189	6	a	a	DT
cord-000238-om92cx5q	189	7	variety	variety	NN
cord-000238-om92cx5q	189	8	of	of	IN
cord-000238-om92cx5q	189	9	different	different	JJ
cord-000238-om92cx5q	189	10	viruses	virus	NNS
cord-000238-om92cx5q	189	11	are	be	VBP
cord-000238-om92cx5q	189	12	warranted	warrant	VBN
cord-000238-om92cx5q	189	13	,	,	,
cord-000238-om92cx5q	189	14	and	and	CC
cord-000238-om92cx5q	189	15	the	the	DT
cord-000238-om92cx5q	189	16	results	result	NNS
cord-000238-om92cx5q	189	17	from	from	IN
cord-000238-om92cx5q	189	18	experimental	experimental	JJ
cord-000238-om92cx5q	189	19	evolution	evolution	NN
cord-000238-om92cx5q	189	20	studies	study	NNS
cord-000238-om92cx5q	189	21	caution	caution	VBP
cord-000238-om92cx5q	189	22	that	that	IN
cord-000238-om92cx5q	189	23	robustness	robustness	NN
cord-000238-om92cx5q	189	24	may	may	MD
cord-000238-om92cx5q	189	25	be	be	VB
cord-000238-om92cx5q	189	26	positively	positively	RB
cord-000238-om92cx5q	189	27	related	relate	VBN
cord-000238-om92cx5q	189	28	to	to	IN
cord-000238-om92cx5q	189	29	evolvability	evolvability	NN
cord-000238-om92cx5q	189	30	and	and	CC
cord-000238-om92cx5q	189	31	to	to	IN
cord-000238-om92cx5q	189	32	competitive	competitive	JJ
cord-000238-om92cx5q	189	33	superiority	superiority	NN
cord-000238-om92cx5q	189	34	in	in	IN
cord-000238-om92cx5q	189	35	RNA	RNA	NNP
cord-000238-om92cx5q	189	36	viruses	virus	NNS
cord-000238-om92cx5q	189	37	.	.	.
cord-000238-om92cx5q	190	1	15	15	CD
cord-000238-om92cx5q	191	1	A	a	DT
cord-000238-om92cx5q	191	2	second	second	JJ
cord-000238-om92cx5q	191	3	experiment	experiment	NN
cord-000238-om92cx5q	191	4	centered	center	VBN
cord-000238-om92cx5q	191	5	closely	closely	RB
cord-000238-om92cx5q	191	6	on	on	IN
cord-000238-om92cx5q	191	7	the	the	DT
cord-000238-om92cx5q	191	8	potential	potential	JJ
cord-000238-om92cx5q	191	9	link	link	NN
cord-000238-om92cx5q	191	10	between	between	IN
cord-000238-om92cx5q	191	11	robustness	robustness	NN
cord-000238-om92cx5q	191	12	and	and	CC
cord-000238-om92cx5q	191	13	pathogen	pathogen	NN
cord-000238-om92cx5q	191	14	evolvability	evolvability	NN
cord-000238-om92cx5q	191	15	on	on	IN
cord-000238-om92cx5q	191	16	novel	novel	JJ
cord-000238-om92cx5q	191	17	hosts	host	NNS
cord-000238-om92cx5q	191	18	.	.	.
cord-000238-om92cx5q	192	1	Environmental	environmental	JJ
cord-000238-om92cx5q	192	2	robustness	robustness	NN
cord-000238-om92cx5q	192	3	of	of	IN
cord-000238-om92cx5q	192	4	a	a	DT
cord-000238-om92cx5q	192	5	virus	virus	NN
cord-000238-om92cx5q	192	6	may	may	MD
cord-000238-om92cx5q	192	7	be	be	VB
cord-000238-om92cx5q	192	8	defined	define	VBN
cord-000238-om92cx5q	192	9	in	in	IN
cord-000238-om92cx5q	192	10	terms	term	NNS
cord-000238-om92cx5q	192	11	of	of	IN
cord-000238-om92cx5q	192	12	its	-PRON-	PRP$
cord-000238-om92cx5q	192	13	host	host	NN
cord-000238-om92cx5q	192	14	generalization	generalization	NN
cord-000238-om92cx5q	192	15	͑host	͑host	NN
cord-000238-om92cx5q	192	16	range	range	NN
cord-000238-om92cx5q	192	17	,	,	,
cord-000238-om92cx5q	192	18	the	the	DT
cord-000238-om92cx5q	192	19	number	number	NN
cord-000238-om92cx5q	192	20	of	of	IN
cord-000238-om92cx5q	192	21	host	host	NN
cord-000238-om92cx5q	192	22	types	type	NNS
cord-000238-om92cx5q	192	23	it	-PRON-	PRP
cord-000238-om92cx5q	192	24	can	can	MD
cord-000238-om92cx5q	192	25	productively	productively	RB
cord-000238-om92cx5q	192	26	infect͒.	infect͒.	NNP
cord-000238-om92cx5q	192	27	44	44	CD
cord-000238-om92cx5q	192	28	Theory	theory	NN
cord-000238-om92cx5q	192	29	predicts	predict	VBZ
cord-000238-om92cx5q	192	30	that	that	IN
cord-000238-om92cx5q	192	31	evolved	evolve	VBD
cord-000238-om92cx5q	192	32	generalization	generalization	NN
cord-000238-om92cx5q	192	33	may	may	MD
cord-000238-om92cx5q	192	34	be	be	VB
cord-000238-om92cx5q	192	35	particularly	particularly	RB
cord-000238-om92cx5q	192	36	useful	useful	JJ
cord-000238-om92cx5q	192	37	if	if	IN
cord-000238-om92cx5q	192	38	organ	organ	NN
cord-000238-om92cx5q	192	39	-	-	HYPH
cord-000238-om92cx5q	192	40	isms	ism	NNS
cord-000238-om92cx5q	192	41	tend	tend	VBP
cord-000238-om92cx5q	192	42	to	to	TO
cord-000238-om92cx5q	192	43	encounter	encounter	VB
cord-000238-om92cx5q	192	44	environments	environment	NNS
cord-000238-om92cx5q	192	45	that	that	WDT
cord-000238-om92cx5q	192	46	change	change	VBP
cord-000238-om92cx5q	192	47	unexpectedly	unexpectedly	RB
cord-000238-om92cx5q	192	48	.	.	.
cord-000238-om92cx5q	193	1	45	45	CD
cord-000238-om92cx5q	194	1	That	that	RB
cord-000238-om92cx5q	194	2	is	is	RB
cord-000238-om92cx5q	194	3	,	,	,
cord-000238-om92cx5q	194	4	generalists	generalist	NNS
cord-000238-om92cx5q	194	5	may	may	MD
cord-000238-om92cx5q	194	6	be	be	VB
cord-000238-om92cx5q	194	7	favored	favor	VBN
cord-000238-om92cx5q	194	8	by	by	IN
cord-000238-om92cx5q	194	9	selection	selection	NN
cord-000238-om92cx5q	194	10	because	because	IN
cord-000238-om92cx5q	194	11	they	-PRON-	PRP
cord-000238-om92cx5q	194	12	are	be	VBP
cord-000238-om92cx5q	194	13	better	well	RBR
cord-000238-om92cx5q	194	14	predisposed	predisposed	JJ
cord-000238-om92cx5q	194	15	to	to	TO
cord-000238-om92cx5q	194	16	survive	survive	VB
cord-000238-om92cx5q	194	17	and	and	CC
cord-000238-om92cx5q	194	18	give	give	VB
cord-000238-om92cx5q	194	19	rise	rise	NN
cord-000238-om92cx5q	194	20	to	to	IN
cord-000238-om92cx5q	194	21	successful	successful	JJ
cord-000238-om92cx5q	194	22	progeny	progeny	NN
cord-000238-om92cx5q	194	23	in	in	IN
cord-000238-om92cx5q	194	24	the	the	DT
cord-000238-om92cx5q	194	25	face	face	NN
cord-000238-om92cx5q	194	26	of	of	IN
cord-000238-om92cx5q	194	27	variable	variable	JJ
cord-000238-om92cx5q	194	28	environments	environment	NNS
cord-000238-om92cx5q	194	29	,	,	,
cord-000238-om92cx5q	194	30	relative	relative	JJ
cord-000238-om92cx5q	194	31	to	to	IN
cord-000238-om92cx5q	194	32	specialists	specialist	NNS
cord-000238-om92cx5q	194	33	that	that	WDT
cord-000238-om92cx5q	194	34	possess	possess	VBP
cord-000238-om92cx5q	194	35	a	a	DT
cord-000238-om92cx5q	194	36	narrow	narrow	JJ
cord-000238-om92cx5q	194	37	niche	niche	NN
cord-000238-om92cx5q	194	38	.	.	.
cord-000238-om92cx5q	195	1	This	this	DT
cord-000238-om92cx5q	195	2	idea	idea	NN
cord-000238-om92cx5q	195	3	may	may	MD
cord-000238-om92cx5q	195	4	explain	explain	VB
cord-000238-om92cx5q	195	5	why	why	WRB
cord-000238-om92cx5q	195	6	pathogens	pathogen	NNS
cord-000238-om92cx5q	195	7	with	with	IN
cord-000238-om92cx5q	195	8	a	a	DT
cord-000238-om92cx5q	195	9	pre	pre	JJ
cord-000238-om92cx5q	195	10	-	-	JJ
cord-000238-om92cx5q	195	11	existing	exist	VBG
cord-000238-om92cx5q	195	12	broad	broad	JJ
cord-000238-om92cx5q	195	13	host	host	NN
cord-000238-om92cx5q	195	14	range	range	NN
cord-000238-om92cx5q	195	15	seem	seem	VBP
cord-000238-om92cx5q	195	16	better	well	RBR
cord-000238-om92cx5q	195	17	able	able	JJ
cord-000238-om92cx5q	195	18	to	to	TO
cord-000238-om92cx5q	195	19	emerge	emerge	VB
cord-000238-om92cx5q	195	20	on	on	IN
cord-000238-om92cx5q	195	21	novel	novel	JJ
cord-000238-om92cx5q	195	22	hosts	host	NNS
cord-000238-om92cx5q	195	23	,	,	,
cord-000238-om92cx5q	195	24	relative	relative	JJ
cord-000238-om92cx5q	195	25	to	to	IN
cord-000238-om92cx5q	195	26	specialized	specialized	JJ
cord-000238-om92cx5q	195	27	pathogens	pathogen	NNS
cord-000238-om92cx5q	195	28	.	.	.
cord-000238-om92cx5q	196	1	[	[	-LRB-
cord-000238-om92cx5q	196	2	46	46	CD
cord-000238-om92cx5q	196	3	]	]	-RRB-
cord-000238-om92cx5q	196	4	[	[	-LRB-
cord-000238-om92cx5q	196	5	47	47	CD
cord-000238-om92cx5q	196	6	]	]	-RRB-
cord-000238-om92cx5q	196	7	[	[	-LRB-
cord-000238-om92cx5q	196	8	48	48	CD
cord-000238-om92cx5q	196	9	]	]	-RRB-
cord-000238-om92cx5q	197	1	To	to	TO
cord-000238-om92cx5q	197	2	test	test	VB
cord-000238-om92cx5q	197	3	this	this	DT
cord-000238-om92cx5q	197	4	idea	idea	NN
cord-000238-om92cx5q	197	5	directly	directly	RB
cord-000238-om92cx5q	197	6	,	,	,
cord-000238-om92cx5q	197	7	we	-PRON-	PRP
cord-000238-om92cx5q	197	8	used	use	VBD
cord-000238-om92cx5q	197	9	populations	population	NNS
cord-000238-om92cx5q	197	10	of	of	IN
cord-000238-om92cx5q	197	11	VSV	VSV	NNP
cord-000238-om92cx5q	197	12	that	that	WDT
cord-000238-om92cx5q	197	13	evolved	evolve	VBD
cord-000238-om92cx5q	197	14	differences	difference	NNS
cord-000238-om92cx5q	197	15	in	in	IN
cord-000238-om92cx5q	197	16	host	host	NN
cord-000238-om92cx5q	197	17	use	use	NN
cord-000238-om92cx5q	197	18	because	because	IN
cord-000238-om92cx5q	197	19	of	of	IN
cord-000238-om92cx5q	197	20	prior	prior	JJ
cord-000238-om92cx5q	197	21	selection	selection	NN
cord-000238-om92cx5q	197	22	in	in	IN
cord-000238-om92cx5q	197	23	constant	constant	JJ
cord-000238-om92cx5q	197	24	versus	versus	IN
cord-000238-om92cx5q	197	25	variable	variable	JJ
cord-000238-om92cx5q	197	26	host	host	NN
cord-000238-om92cx5q	197	27	environments	environment	NNS
cord-000238-om92cx5q	197	28	.	.	.
cord-000238-om92cx5q	198	1	49	49	CD
cord-000238-om92cx5q	198	2	,	,	,
cord-000238-om92cx5q	198	3	50	50	CD
cord-000238-om92cx5q	198	4	The	the	DT
cord-000238-om92cx5q	198	5	formal	formal	JJ
cord-000238-om92cx5q	198	6	prediction	prediction	NN
cord-000238-om92cx5q	198	7	was	be	VBD
cord-000238-om92cx5q	198	8	that	that	IN
cord-000238-om92cx5q	198	9	VSV	VSV	NNP
cord-000238-om92cx5q	198	10	populations	population	NNS
cord-000238-om92cx5q	198	11	experiencing	experience	VBG
cord-000238-om92cx5q	198	12	direct	direct	JJ
cord-000238-om92cx5q	198	13	selection	selection	NN
cord-000238-om92cx5q	198	14	for	for	IN
cord-000238-om92cx5q	198	15	host	host	NN
cord-000238-om92cx5q	198	16	range	range	NN
cord-000238-om92cx5q	198	17	would	would	MD
cord-000238-om92cx5q	198	18	have	have	VB
cord-000238-om92cx5q	198	19	higher	high	JJR
cord-000238-om92cx5q	198	20	mean	mean	JJ
cord-000238-om92cx5q	198	21	growth	growth	NN
cord-000238-om92cx5q	198	22	and	and	CC
cord-000238-om92cx5q	198	23	less	less	JJR
cord-000238-om92cx5q	198	24	variance	variance	NN
cord-000238-om92cx5q	198	25	in	in	IN
cord-000238-om92cx5q	198	26	mean	mean	JJ
cord-000238-om92cx5q	198	27	growth	growth	NN
cord-000238-om92cx5q	198	28	on	on	IN
cord-000238-om92cx5q	198	29	a	a	DT
cord-000238-om92cx5q	198	30	collection	collection	NN
cord-000238-om92cx5q	198	31	of	of	IN
cord-000238-om92cx5q	198	32	challenge	challenge	NN
cord-000238-om92cx5q	198	33	hosts	host	NNS
cord-000238-om92cx5q	198	34	,	,	,
cord-000238-om92cx5q	198	35	compared	compare	VBN
cord-000238-om92cx5q	198	36	to	to	IN
cord-000238-om92cx5q	198	37	VSV	VSV	NNP
cord-000238-om92cx5q	198	38	populations	population	NNS
cord-000238-om92cx5q	198	39	that	that	WDT
cord-000238-om92cx5q	198	40	were	be	VBD
cord-000238-om92cx5q	198	41	either	either	CC
cord-000238-om92cx5q	198	42	relatively	relatively	RB
cord-000238-om92cx5q	198	43	specialized	specialized	JJ
cord-000238-om92cx5q	198	44	or	or	CC
cord-000238-om92cx5q	198	45	indirectly	indirectly	RB
cord-000238-om92cx5q	198	46	selected	select	VBN
cord-000238-om92cx5q	198	47	for	for	IN
cord-000238-om92cx5q	198	48	host	host	NN
cord-000238-om92cx5q	198	49	range	range	NN
cord-000238-om92cx5q	198	50	.	.	.
cord-000238-om92cx5q	199	1	51	51	CD
cord-000238-om92cx5q	200	1	When	when	WRB
cord-000238-om92cx5q	200	2	challenged	challenge	VBN
cord-000238-om92cx5q	200	3	to	to	TO
cord-000238-om92cx5q	200	4	grow	grow	VB
cord-000238-om92cx5q	200	5	on	on	IN
cord-000238-om92cx5q	200	6	four	four	CD
cord-000238-om92cx5q	200	7	novel	novel	JJ
cord-000238-om92cx5q	200	8	hosts	host	NNS
cord-000238-om92cx5q	200	9	in	in	IN
cord-000238-om92cx5q	200	10	vitro	vitro	FW
cord-000238-om92cx5q	200	11	,	,	,
cord-000238-om92cx5q	200	12	the	the	DT
cord-000238-om92cx5q	200	13	viruses	virus	NNS
cord-000238-om92cx5q	200	14	that	that	WDT
cord-000238-om92cx5q	200	15	had	have	VBD
cord-000238-om92cx5q	200	16	been	be	VBN
cord-000238-om92cx5q	200	17	selected	select	VBN
cord-000238-om92cx5q	200	18	for	for	IN
cord-000238-om92cx5q	200	19	generalism	generalism	NN
cord-000238-om92cx5q	200	20	exhibited	exhibit	VBD
cord-000238-om92cx5q	200	21	higher	high	JJR
cord-000238-om92cx5q	200	22	or	or	CC
cord-000238-om92cx5q	200	23	equivalent	equivalent	JJ
cord-000238-om92cx5q	200	24	host	host	NN
cord-000238-om92cx5q	200	25	growth	growth	NN
cord-000238-om92cx5q	200	26	,	,	,
cord-000238-om92cx5q	200	27	lower	low	JJR
cord-000238-om92cx5q	200	28	among	among	IN
cord-000238-om92cx5q	200	29	-	-	HYPH
cord-000238-om92cx5q	200	30	population	population	NN
cord-000238-om92cx5q	200	31	variance	variance	NN
cord-000238-om92cx5q	200	32	in	in	IN
cord-000238-om92cx5q	200	33	host	host	NN
cord-000238-om92cx5q	200	34	growth	growth	NN
cord-000238-om92cx5q	200	35	,	,	,
cord-000238-om92cx5q	200	36	and	and	CC
cord-000238-om92cx5q	200	37	lower	low	JJR
cord-000238-om92cx5q	200	38	variance	variance	NN
cord-000238-om92cx5q	200	39	in	in	IN
cord-000238-om92cx5q	200	40	population	population	NN
cord-000238-om92cx5q	200	41	growth	growth	NN
cord-000238-om92cx5q	200	42	across	across	IN
cord-000238-om92cx5q	200	43	hosts	host	NNS
cord-000238-om92cx5q	200	44	.	.	.
cord-000238-om92cx5q	201	1	Thus	thus	RB
cord-000238-om92cx5q	201	2	,	,	,
cord-000238-om92cx5q	201	3	these	these	DT
cord-000238-om92cx5q	201	4	three	three	CD
cord-000238-om92cx5q	201	5	predictions	prediction	NNS
cord-000238-om92cx5q	201	6	relating	relate	VBG
cord-000238-om92cx5q	201	7	to	to	IN
cord-000238-om92cx5q	201	8	the	the	DT
cord-000238-om92cx5q	201	9	hypothesis	hypothesis	NN
cord-000238-om92cx5q	201	10	were	be	VBD
cord-000238-om92cx5q	201	11	generally	generally	RB
cord-000238-om92cx5q	201	12	supported	support	VBN
cord-000238-om92cx5q	201	13	because	because	IN
cord-000238-om92cx5q	201	14	direct	direct	JJ
cord-000238-om92cx5q	201	15	selection	selection	NN
cord-000238-om92cx5q	201	16	for	for	IN
cord-000238-om92cx5q	201	17	host	host	NN
cord-000238-om92cx5q	201	18	breadth	breadth	NN
cord-000238-om92cx5q	201	19	more	more	RBR
cord-000238-om92cx5q	201	20	often	often	RB
cord-000238-om92cx5q	201	21	allowed	allow	VBN
cord-000238-om92cx5q	201	22	successful	successful	JJ
cord-000238-om92cx5q	201	23	emergence	emergence	NN
cord-000238-om92cx5q	201	24	.	.	.
cord-000238-om92cx5q	202	1	The	the	DT
cord-000238-om92cx5q	202	2	results	result	NNS
cord-000238-om92cx5q	202	3	suggested	suggest	VBD
cord-000238-om92cx5q	202	4	that	that	IN
cord-000238-om92cx5q	202	5	determination	determination	NN
cord-000238-om92cx5q	202	6	of	of	IN
cord-000238-om92cx5q	202	7	current	current	JJ
cord-000238-om92cx5q	202	8	niche	niche	NN
cord-000238-om92cx5q	202	9	breadth	breadth	NN
cord-000238-om92cx5q	202	10	should	should	MD
cord-000238-om92cx5q	202	11	be	be	VB
cord-000238-om92cx5q	202	12	further	further	RB
cord-000238-om92cx5q	202	13	investigated	investigate	VBN
cord-000238-om92cx5q	202	14	as	as	IN
cord-000238-om92cx5q	202	15	a	a	DT
cord-000238-om92cx5q	202	16	potentially	potentially	RB
cord-000238-om92cx5q	202	17	useful	useful	JJ
cord-000238-om92cx5q	202	18	indicator	indicator	NN
cord-000238-om92cx5q	202	19	in	in	IN
cord-000238-om92cx5q	202	20	predicting	predict	VBG
cord-000238-om92cx5q	202	21	pathogen	pathogen	NN
cord-000238-om92cx5q	202	22	emergence	emergence	NN
cord-000238-om92cx5q	202	23	.	.	.
cord-000238-om92cx5q	203	1	51	51	CD
cord-000238-om92cx5q	203	2	,	,	,
cord-000238-om92cx5q	203	3	52	52	CD
cord-000238-om92cx5q	203	4	Because	because	IN
cord-000238-om92cx5q	203	5	these	these	DT
cord-000238-om92cx5q	203	6	many	many	JJ
cord-000238-om92cx5q	203	7	recent	recent	JJ
cord-000238-om92cx5q	203	8	empirical	empirical	JJ
cord-000238-om92cx5q	203	9	breakthroughs	breakthrough	NNS
cord-000238-om92cx5q	203	10	in	in	IN
cord-000238-om92cx5q	203	11	the	the	DT
cord-000238-om92cx5q	203	12	study	study	NN
cord-000238-om92cx5q	203	13	of	of	IN
cord-000238-om92cx5q	203	14	robustness	robustness	NN
cord-000238-om92cx5q	203	15	have	have	VBP
cord-000238-om92cx5q	203	16	involved	involve	VBN
cord-000238-om92cx5q	203	17	microbes	microbe	NNS
cord-000238-om92cx5q	203	18	,	,	,
cord-000238-om92cx5q	203	19	one	one	PRP
cord-000238-om92cx5q	203	20	might	may	MD
cord-000238-om92cx5q	203	21	predict	predict	VB
cord-000238-om92cx5q	203	22	that	that	IN
cord-000238-om92cx5q	203	23	infectious	infectious	JJ
cord-000238-om92cx5q	203	24	disease	disease	NN
cord-000238-om92cx5q	203	25	is	be	VBZ
cord-000238-om92cx5q	203	26	the	the	DT
cord-000238-om92cx5q	203	27	primary	primary	JJ
cord-000238-om92cx5q	203	28	biomedical	biomedical	JJ
cord-000238-om92cx5q	203	29	realm	realm	NN
cord-000238-om92cx5q	203	30	where	where	WRB
cord-000238-om92cx5q	203	31	these	these	DT
cord-000238-om92cx5q	203	32	robustness	robustness	NN
cord-000238-om92cx5q	203	33	results	result	NNS
cord-000238-om92cx5q	203	34	might	may	MD
cord-000238-om92cx5q	203	35	have	have	VB
cord-000238-om92cx5q	203	36	an	an	DT
cord-000238-om92cx5q	203	37	immediate	immediate	JJ
cord-000238-om92cx5q	203	38	,	,	,
cord-000238-om92cx5q	203	39	practical	practical	JJ
cord-000238-om92cx5q	203	40	impact	impact	NN
cord-000238-om92cx5q	203	41	.	.	.
cord-000238-om92cx5q	204	1	Below	below	IN
cord-000238-om92cx5q	204	2	we	-PRON-	PRP
cord-000238-om92cx5q	204	3	describe	describe	VBP
cord-000238-om92cx5q	204	4	three	three	CD
cord-000238-om92cx5q	204	5	examples	example	NNS
cord-000238-om92cx5q	204	6	of	of	IN
cord-000238-om92cx5q	204	7	biomedically	biomedically	RB
cord-000238-om92cx5q	204	8	important	important	JJ
cord-000238-om92cx5q	204	9	human	human	JJ
cord-000238-om92cx5q	204	10	disease	disease	NN
cord-000238-om92cx5q	204	11	systems	system	NNS
cord-000238-om92cx5q	204	12	where	where	WRB
cord-000238-om92cx5q	204	13	robustness	robustness	NN
cord-000238-om92cx5q	204	14	theory	theory	NN
cord-000238-om92cx5q	204	15	appears	appear	VBZ
cord-000238-om92cx5q	204	16	highly	highly	RB
cord-000238-om92cx5q	204	17	relevant	relevant	JJ
cord-000238-om92cx5q	204	18	.	.	.
cord-000238-om92cx5q	205	1	The	the	DT
cord-000238-om92cx5q	205	2	effects	effect	NNS
cord-000238-om92cx5q	205	3	of	of	IN
cord-000238-om92cx5q	205	4	evolution	evolution	NN
cord-000238-om92cx5q	205	5	are	be	VBP
cord-000238-om92cx5q	205	6	sometimes	sometimes	RB
cord-000238-om92cx5q	205	7	difficult	difficult	JJ
cord-000238-om92cx5q	205	8	to	to	TO
cord-000238-om92cx5q	205	9	perceive	perceive	VB
cord-000238-om92cx5q	205	10	in	in	IN
cord-000238-om92cx5q	205	11	daily	daily	JJ
cord-000238-om92cx5q	205	12	life	life	NN
cord-000238-om92cx5q	205	13	,	,	,
cord-000238-om92cx5q	205	14	making	make	VBG
cord-000238-om92cx5q	205	15	public	public	JJ
cord-000238-om92cx5q	205	16	skepticism	skepticism	NN
cord-000238-om92cx5q	205	17	of	of	IN
cord-000238-om92cx5q	205	18	the	the	DT
cord-000238-om92cx5q	205	19	existence	existence	NN
cord-000238-om92cx5q	205	20	of	of	IN
cord-000238-om92cx5q	205	21	evolution	evolution	NN
cord-000238-om92cx5q	205	22	all	all	PDT
cord-000238-om92cx5q	205	23	the	the	DT
cord-000238-om92cx5q	205	24	more	more	RBR
cord-000238-om92cx5q	205	25	challenging	challenging	JJ
cord-000238-om92cx5q	205	26	to	to	TO
cord-000238-om92cx5q	205	27	address	address	VB
cord-000238-om92cx5q	205	28	.	.	.
cord-000238-om92cx5q	206	1	Perhaps	perhaps	RB
cord-000238-om92cx5q	206	2	the	the	DT
cord-000238-om92cx5q	206	3	foremost	foremost	JJ
cord-000238-om92cx5q	206	4	example	example	NN
cord-000238-om92cx5q	206	5	used	use	VBN
cord-000238-om92cx5q	206	6	to	to	TO
cord-000238-om92cx5q	206	7	counter	counter	VB
cord-000238-om92cx5q	206	8	these	these	DT
cord-000238-om92cx5q	206	9	notions	notion	NNS
cord-000238-om92cx5q	206	10	is	be	VBZ
cord-000238-om92cx5q	206	11	the	the	DT
cord-000238-om92cx5q	206	12	widespread	widespread	JJ
cord-000238-om92cx5q	206	13	problem	problem	NN
cord-000238-om92cx5q	206	14	of	of	IN
cord-000238-om92cx5q	206	15	resurgent	resurgent	JJ
cord-000238-om92cx5q	206	16	diseases	disease	NNS
cord-000238-om92cx5q	206	17	that	that	WDT
cord-000238-om92cx5q	206	18	had	have	VBD
cord-000238-om92cx5q	206	19	been	be	VBN
cord-000238-om92cx5q	206	20	previously	previously	RB
cord-000238-om92cx5q	206	21	treated	treat	VBN
cord-000238-om92cx5q	206	22	through	through	IN
cord-000238-om92cx5q	206	23	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	206	24	,	,	,
cord-000238-om92cx5q	206	25	especially	especially	RB
cord-000238-om92cx5q	206	26	evolved	evolve	VBN
cord-000238-om92cx5q	206	27	resistance	resistance	NN
cord-000238-om92cx5q	206	28	in	in	IN
cord-000238-om92cx5q	206	29	bacterial	bacterial	JJ
cord-000238-om92cx5q	206	30	pathogens	pathogen	NNS
cord-000238-om92cx5q	206	31	.	.	.
cord-000238-om92cx5q	207	1	Although	although	IN
cord-000238-om92cx5q	207	2	naturally	naturally	RB
cord-000238-om92cx5q	207	3	produced	produce	VBN
cord-000238-om92cx5q	207	4	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	207	5	evolved	evolve	VBN
cord-000238-om92cx5q	207	6	in	in	IN
cord-000238-om92cx5q	207	7	microbial	microbial	JJ
cord-000238-om92cx5q	207	8	communities	community	NNS
cord-000238-om92cx5q	207	9	long	long	RB
cord-000238-om92cx5q	207	10	before	before	IN
cord-000238-om92cx5q	207	11	humans	human	NNS
cord-000238-om92cx5q	207	12	appeared	appear	VBD
cord-000238-om92cx5q	207	13	as	as	IN
cord-000238-om92cx5q	207	14	a	a	DT
cord-000238-om92cx5q	207	15	species	species	NN
cord-000238-om92cx5q	207	16	,	,	,
cord-000238-om92cx5q	207	17	the	the	DT
cord-000238-om92cx5q	207	18	medical	medical	JJ
cord-000238-om92cx5q	207	19	realm	realm	NN
cord-000238-om92cx5q	207	20	began	begin	VBD
cord-000238-om92cx5q	207	21	earnestly	earnestly	RB
cord-000238-om92cx5q	207	22	administering	administer	VBG
cord-000238-om92cx5q	207	23	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	207	24	drugs	drug	NNS
cord-000238-om92cx5q	207	25	only	only	RB
cord-000238-om92cx5q	207	26	since	since	IN
cord-000238-om92cx5q	207	27	their	-PRON-	PRP$
cord-000238-om92cx5q	207	28	discovery	discovery	NN
cord-000238-om92cx5q	207	29	in	in	IN
cord-000238-om92cx5q	207	30	the	the	DT
cord-000238-om92cx5q	207	31	1950s	1950s	CD
cord-000238-om92cx5q	207	32	.	.	.
cord-000238-om92cx5q	208	1	Widespread	widespread	JJ
cord-000238-om92cx5q	208	2	production	production	NN
cord-000238-om92cx5q	208	3	and	and	CC
cord-000238-om92cx5q	208	4	utilization	utilization	NN
cord-000238-om92cx5q	208	5	of	of	IN
cord-000238-om92cx5q	208	6	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	208	7	in	in	IN
cord-000238-om92cx5q	208	8	medicine	medicine	NN
cord-000238-om92cx5q	208	9	and	and	CC
cord-000238-om92cx5q	208	10	agriculture	agriculture	NN
cord-000238-om92cx5q	208	11	,	,	,
cord-000238-om92cx5q	208	12	however	however	RB
cord-000238-om92cx5q	208	13	,	,	,
cord-000238-om92cx5q	208	14	has	have	VBZ
cord-000238-om92cx5q	208	15	created	create	VBN
cord-000238-om92cx5q	208	16	a	a	DT
cord-000238-om92cx5q	208	17	massive	massive	JJ
cord-000238-om92cx5q	208	18	uncontrolled	uncontrolled	JJ
cord-000238-om92cx5q	208	19	experiment	experiment	NN
cord-000238-om92cx5q	208	20	in	in	IN
cord-000238-om92cx5q	208	21	which	which	WDT
cord-000238-om92cx5q	208	22	bacteria	bacteria	NNS
cord-000238-om92cx5q	208	23	have	have	VBP
cord-000238-om92cx5q	208	24	been	be	VBN
cord-000238-om92cx5q	208	25	selected	select	VBN
cord-000238-om92cx5q	208	26	to	to	TO
cord-000238-om92cx5q	208	27	harbor	harbor	VB
cord-000238-om92cx5q	208	28	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	208	29	resistance	resistance	NN
cord-000238-om92cx5q	208	30	genes	gene	NNS
cord-000238-om92cx5q	208	31	,	,	,
cord-000238-om92cx5q	208	32	making	make	VBG
cord-000238-om92cx5q	208	33	existing	exist	VBG
cord-000238-om92cx5q	208	34	therapies	therapy	NNS
cord-000238-om92cx5q	208	35	largely	largely	RB
cord-000238-om92cx5q	208	36	ineffective	ineffective	JJ
cord-000238-om92cx5q	208	37	in	in	IN
cord-000238-om92cx5q	208	38	many	many	JJ
cord-000238-om92cx5q	208	39	clinical	clinical	JJ
cord-000238-om92cx5q	208	40	circumstances	circumstance	NNS
cord-000238-om92cx5q	208	41	.	.	.
cord-000238-om92cx5q	209	1	Bacterial	bacterial	JJ
cord-000238-om92cx5q	209	2	resistance	resistance	NN
cord-000238-om92cx5q	209	3	to	to	IN
cord-000238-om92cx5q	209	4	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	209	5	and	and	CC
cord-000238-om92cx5q	209	6	other	other	JJ
cord-000238-om92cx5q	209	7	harmful	harmful	JJ
cord-000238-om92cx5q	209	8	substances	substance	NNS
cord-000238-om92cx5q	209	9	͑e.g	͑e.g	,
cord-000238-om92cx5q	209	10	.	.	.
cord-000238-om92cx5q	210	1	,	,	,
cord-000238-om92cx5q	210	2	heavy	heavy	JJ
cord-000238-om92cx5q	210	3	metals͒	metals͒	NN
cord-000238-om92cx5q	210	4	often	often	RB
cord-000238-om92cx5q	210	5	occurs	occur	VBZ
cord-000238-om92cx5q	210	6	through	through	IN
cord-000238-om92cx5q	210	7	genes	gene	NNS
cord-000238-om92cx5q	210	8	carried	carry	VBN
cord-000238-om92cx5q	210	9	on	on	IN
cord-000238-om92cx5q	210	10	plasmids	plasmid	NNS
cord-000238-om92cx5q	210	11	:	:	:
cord-000238-om92cx5q	210	12	autonomously	autonomously	RB
cord-000238-om92cx5q	210	13	replicating	replicate	VBG
cord-000238-om92cx5q	210	14	DNA	dna	NN
cord-000238-om92cx5q	210	15	elements	element	NNS
cord-000238-om92cx5q	210	16	that	that	WDT
cord-000238-om92cx5q	210	17	are	be	VBP
cord-000238-om92cx5q	210	18	nearly	nearly	RB
cord-000238-om92cx5q	210	19	ubiquitous	ubiquitous	JJ
cord-000238-om92cx5q	210	20	in	in	IN
cord-000238-om92cx5q	210	21	bacterial	bacterial	JJ
cord-000238-om92cx5q	210	22	populations	population	NNS
cord-000238-om92cx5q	210	23	.	.	.
cord-000238-om92cx5q	211	1	Individual	individual	JJ
cord-000238-om92cx5q	211	2	plasmids	plasmid	NNS
cord-000238-om92cx5q	211	3	can	can	MD
cord-000238-om92cx5q	211	4	sometimes	sometimes	RB
cord-000238-om92cx5q	211	5	include	include	VB
cord-000238-om92cx5q	211	6	multiple	multiple	JJ
cord-000238-om92cx5q	211	7	genes	gene	NNS
cord-000238-om92cx5q	211	8	conferring	confer	VBG
cord-000238-om92cx5q	211	9	resistance	resistance	NN
cord-000238-om92cx5q	211	10	to	to	IN
cord-000238-om92cx5q	211	11	a	a	DT
cord-000238-om92cx5q	211	12	variety	variety	NN
cord-000238-om92cx5q	211	13	of	of	IN
cord-000238-om92cx5q	211	14	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	211	15	.	.	.
cord-000238-om92cx5q	212	1	Also	also	RB
cord-000238-om92cx5q	212	2	,	,	,
cord-000238-om92cx5q	212	3	plasmids	plasmid	NNS
cord-000238-om92cx5q	212	4	can	can	MD
cord-000238-om92cx5q	212	5	effectively	effectively	RB
cord-000238-om92cx5q	212	6	spread	spread	VB
cord-000238-om92cx5q	212	7	within	within	IN
cord-000238-om92cx5q	212	8	and	and	CC
cord-000238-om92cx5q	212	9	among	among	IN
cord-000238-om92cx5q	212	10	bacteria	bacteria	NNS
cord-000238-om92cx5q	212	11	populations	population	NNS
cord-000238-om92cx5q	212	12	and	and	CC
cord-000238-om92cx5q	212	13	species	specie	NNS
cord-000238-om92cx5q	212	14	through	through	IN
cord-000238-om92cx5q	212	15	conjugation	conjugation	NN
cord-000238-om92cx5q	212	16	͑cell	͑cell	NN
cord-000238-om92cx5q	212	17	-	-	HYPH
cord-000238-om92cx5q	212	18	to	to	IN
cord-000238-om92cx5q	212	19	-	-	HYPH
cord-000238-om92cx5q	212	20	cell	cell	NN
cord-000238-om92cx5q	212	21	horizontal	horizontal	NN
cord-000238-om92cx5q	213	1	transfer͒.	transfer͒.	NNP
cord-000238-om92cx5q	213	2	Together	together	RB
cord-000238-om92cx5q	213	3	,	,	,
cord-000238-om92cx5q	213	4	these	these	DT
cord-000238-om92cx5q	213	5	features	feature	NNS
cord-000238-om92cx5q	213	6	create	create	VBP
cord-000238-om92cx5q	213	7	the	the	DT
cord-000238-om92cx5q	213	8	capacity	capacity	NN
cord-000238-om92cx5q	213	9	for	for	IN
cord-000238-om92cx5q	213	10	rapid	rapid	JJ
cord-000238-om92cx5q	213	11	spread	spread	NN
cord-000238-om92cx5q	213	12	of	of	IN
cord-000238-om92cx5q	213	13	multiple	multiple	JJ
cord-000238-om92cx5q	213	14	drug	drug	NN
cord-000238-om92cx5q	213	15	resistance	resistance	NN
cord-000238-om92cx5q	213	16	in	in	IN
cord-000238-om92cx5q	213	17	bacteria	bacteria	NNS
cord-000238-om92cx5q	213	18	.	.	.
cord-000238-om92cx5q	214	1	Furthermore	furthermore	RB
cord-000238-om92cx5q	214	2	,	,	,
cord-000238-om92cx5q	214	3	plasmid	plasmid	NN
cord-000238-om92cx5q	214	4	-	-	HYPH
cord-000238-om92cx5q	214	5	borne	bear	VBN
cord-000238-om92cx5q	214	6	mechanisms	mechanism	NNS
cord-000238-om92cx5q	215	1	͑e.g	͑e.g	,
cord-000238-om92cx5q	215	2	.	.	.
cord-000238-om92cx5q	216	1	,	,	,
cord-000238-om92cx5q	216	2	postsegregational	postsegregational	NNP
cord-000238-om92cx5q	216	3	killing͒	killing͒	NNP
cord-000238-om92cx5q	216	4	often	often	RB
cord-000238-om92cx5q	216	5	exist	exist	VBP
cord-000238-om92cx5q	216	6	to	to	TO
cord-000238-om92cx5q	216	7	ensure	ensure	VB
cord-000238-om92cx5q	216	8	that	that	IN
cord-000238-om92cx5q	216	9	vertical	vertical	JJ
cord-000238-om92cx5q	216	10	transfer	transfer	NN
cord-000238-om92cx5q	216	11	͑plasmid	͑plasmid	NN
cord-000238-om92cx5q	216	12	inherit	inherit	VB
cord-000238-om92cx5q	216	13	-	-	HYPH
cord-000238-om92cx5q	216	14	ance͒	ance͒	NN
cord-000238-om92cx5q	216	15	is	be	VBZ
cord-000238-om92cx5q	216	16	reliably	reliably	RB
cord-000238-om92cx5q	216	17	maintained	maintain	VBN
cord-000238-om92cx5q	216	18	across	across	IN
cord-000238-om92cx5q	216	19	host	host	NN
cord-000238-om92cx5q	216	20	-	-	HYPH
cord-000238-om92cx5q	216	21	cell	cell	NN
cord-000238-om92cx5q	216	22	generations	generation	NNS
cord-000238-om92cx5q	216	23	.	.	.
cord-000238-om92cx5q	217	1	For	for	IN
cord-000238-om92cx5q	217	2	these	these	DT
cord-000238-om92cx5q	217	3	reasons	reason	NNS
cord-000238-om92cx5q	217	4	,	,	,
cord-000238-om92cx5q	217	5	plasmid	plasmid	NN
cord-000238-om92cx5q	217	6	biology	biology	NN
cord-000238-om92cx5q	217	7	has	have	VBZ
cord-000238-om92cx5q	217	8	undoubtedly	undoubtedly	RB
cord-000238-om92cx5q	217	9	contributed	contribute	VBN
cord-000238-om92cx5q	217	10	to	to	IN
cord-000238-om92cx5q	217	11	the	the	DT
cord-000238-om92cx5q	217	12	current	current	JJ
cord-000238-om92cx5q	217	13	crisis	crisis	NN
cord-000238-om92cx5q	217	14	of	of	IN
cord-000238-om92cx5q	217	15	ineffective	ineffective	JJ
cord-000238-om92cx5q	217	16	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	217	17	therapy	therapy	NN
cord-000238-om92cx5q	217	18	.	.	.
cord-000238-om92cx5q	218	1	Plasmid	plasmid	NN
cord-000238-om92cx5q	218	2	-	-	HYPH
cord-000238-om92cx5q	218	3	bearing	bear	VBG
cord-000238-om92cx5q	218	4	bacteria	bacteria	NNS
cord-000238-om92cx5q	218	5	that	that	WDT
cord-000238-om92cx5q	218	6	are	be	VBP
cord-000238-om92cx5q	218	7	resistant	resistant	JJ
cord-000238-om92cx5q	218	8	to	to	IN
cord-000238-om92cx5q	218	9	a	a	DT
cord-000238-om92cx5q	218	10	wide	wide	JJ
cord-000238-om92cx5q	218	11	variety	variety	NN
cord-000238-om92cx5q	218	12	of	of	IN
cord-000238-om92cx5q	218	13	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	218	14	can	can	MD
cord-000238-om92cx5q	218	15	be	be	VB
cord-000238-om92cx5q	218	16	defined	define	VBN
cord-000238-om92cx5q	218	17	as	as	IN
cord-000238-om92cx5q	218	18	relatively	relatively	RB
cord-000238-om92cx5q	218	19	environmentally	environmentally	RB
cord-000238-om92cx5q	218	20	robust	robust	JJ
cord-000238-om92cx5q	218	21	,	,	,
cord-000238-om92cx5q	218	22	compared	compare	VBN
cord-000238-om92cx5q	218	23	to	to	IN
cord-000238-om92cx5q	218	24	bacteria	bacteria	NNS
cord-000238-om92cx5q	218	25	strains	strain	NNS
cord-000238-om92cx5q	218	26	unable	unable	JJ
cord-000238-om92cx5q	218	27	to	to	TO
cord-000238-om92cx5q	218	28	grow	grow	VB
cord-000238-om92cx5q	218	29	in	in	IN
cord-000238-om92cx5q	218	30	the	the	DT
cord-000238-om92cx5q	218	31	presence	presence	NN
cord-000238-om92cx5q	218	32	of	of	IN
cord-000238-om92cx5q	218	33	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	218	34	challenges	challenge	NNS
cord-000238-om92cx5q	218	35	.	.	.
cord-000238-om92cx5q	219	1	Whether	whether	IN
cord-000238-om92cx5q	219	2	this	this	DT
cord-000238-om92cx5q	219	3	difference	difference	NN
cord-000238-om92cx5q	219	4	arose	arise	VBD
cord-000238-om92cx5q	219	5	largely	largely	RB
cord-000238-om92cx5q	219	6	through	through	IN
cord-000238-om92cx5q	219	7	selection	selection	NN
cord-000238-om92cx5q	219	8	acting	act	VBG
cord-000238-om92cx5q	219	9	at	at	IN
cord-000238-om92cx5q	219	10	the	the	DT
cord-000238-om92cx5q	219	11	level	level	NN
cord-000238-om92cx5q	219	12	of	of	IN
cord-000238-om92cx5q	219	13	bacteria	bacteria	NNS
cord-000238-om92cx5q	219	14	,	,	,
cord-000238-om92cx5q	219	15	or	or	CC
cord-000238-om92cx5q	219	16	purely	purely	RB
cord-000238-om92cx5q	219	17	at	at	IN
cord-000238-om92cx5q	219	18	the	the	DT
cord-000238-om92cx5q	219	19	level	level	NN
cord-000238-om92cx5q	219	20	of	of	IN
cord-000238-om92cx5q	219	21	plasmids	plasmid	NNS
cord-000238-om92cx5q	219	22	,	,	,
cord-000238-om92cx5q	219	23	is	be	VBZ
cord-000238-om92cx5q	219	24	unclear	unclear	JJ
cord-000238-om92cx5q	219	25	.	.	.
cord-000238-om92cx5q	220	1	In	in	IN
cord-000238-om92cx5q	220	2	the	the	DT
cord-000238-om92cx5q	220	3	former	former	JJ
cord-000238-om92cx5q	220	4	case	case	NN
cord-000238-om92cx5q	220	5	,	,	,
cord-000238-om92cx5q	220	6	acquisition	acquisition	NN
cord-000238-om92cx5q	220	7	and	and	CC
cord-000238-om92cx5q	220	8	maintenance	maintenance	NN
cord-000238-om92cx5q	220	9	of	of	IN
cord-000238-om92cx5q	220	10	a	a	DT
cord-000238-om92cx5q	220	11	large	large	JJ
cord-000238-om92cx5q	220	12	number	number	NN
cord-000238-om92cx5q	220	13	of	of	IN
cord-000238-om92cx5q	220	14	resistance	resistance	NN
cord-000238-om92cx5q	220	15	genes	gene	NNS
cord-000238-om92cx5q	220	16	could	could	MD
cord-000238-om92cx5q	220	17	be	be	VB
cord-000238-om92cx5q	220	18	evolved	evolve	VBN
cord-000238-om92cx5q	220	19	"	"	``
cord-000238-om92cx5q	220	20	bet	bet	NN
cord-000238-om92cx5q	220	21	-	-	HYPH
cord-000238-om92cx5q	220	22	hedging	hedging	NN
cord-000238-om92cx5q	220	23	"	"	''
cord-000238-om92cx5q	220	24	in	in	IN
cord-000238-om92cx5q	220	25	bacteria	bacteria	NNS
cord-000238-om92cx5q	220	26	,	,	,
cord-000238-om92cx5q	220	27	where	where	WRB
cord-000238-om92cx5q	220	28	selected	select	VBN
cord-000238-om92cx5q	220	29	retention	retention	NN
cord-000238-om92cx5q	220	30	of	of	IN
cord-000238-om92cx5q	220	31	these	these	DT
cord-000238-om92cx5q	220	32	alleles	allele	NNS
cord-000238-om92cx5q	220	33	occurs	occur	VBZ
cord-000238-om92cx5q	220	34	despite	despite	IN
cord-000238-om92cx5q	220	35	only	only	RB
cord-000238-om92cx5q	220	36	rare	rare	JJ
cord-000238-om92cx5q	220	37	circumstances	circumstance	NNS
cord-000238-om92cx5q	220	38	when	when	WRB
cord-000238-om92cx5q	220	39	they	-PRON-	PRP
cord-000238-om92cx5q	220	40	are	be	VBP
cord-000238-om92cx5q	220	41	actually	actually	RB
cord-000238-om92cx5q	220	42	needed	need	VBN
cord-000238-om92cx5q	220	43	to	to	TO
cord-000238-om92cx5q	220	44	protect	protect	VB
cord-000238-om92cx5q	220	45	against	against	IN
cord-000238-om92cx5q	220	46	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	220	47	.	.	.
cord-000238-om92cx5q	221	1	Alternatively	alternatively	RB
cord-000238-om92cx5q	221	2	,	,	,
cord-000238-om92cx5q	221	3	selection	selection	NN
cord-000238-om92cx5q	221	4	may	may	MD
cord-000238-om92cx5q	221	5	be	be	VB
cord-000238-om92cx5q	221	6	acting	act	VBG
cord-000238-om92cx5q	221	7	purely	purely	RB
cord-000238-om92cx5q	221	8	at	at	IN
cord-000238-om92cx5q	221	9	the	the	DT
cord-000238-om92cx5q	221	10	level	level	NN
cord-000238-om92cx5q	221	11	of	of	IN
cord-000238-om92cx5q	221	12	plasmids	plasmid	NNS
cord-000238-om92cx5q	221	13	,	,	,
cord-000238-om92cx5q	221	14	favoring	favor	VBG
cord-000238-om92cx5q	221	15	infectious	infectious	JJ
cord-000238-om92cx5q	221	16	genetic	genetic	JJ
cord-000238-om92cx5q	221	17	elements	element	NNS
cord-000238-om92cx5q	221	18	that	that	WDT
cord-000238-om92cx5q	221	19	collect	collect	VBP
cord-000238-om92cx5q	221	20	resistance	resistance	NN
cord-000238-om92cx5q	221	21	genes	gene	NNS
cord-000238-om92cx5q	221	22	which	which	WDT
cord-000238-om92cx5q	221	23	may	may	MD
cord-000238-om92cx5q	221	24	be	be	VB
cord-000238-om92cx5q	221	25	beneficial	beneficial	JJ
cord-000238-om92cx5q	221	26	for	for	IN
cord-000238-om92cx5q	221	27	"	"	``
cord-000238-om92cx5q	221	28	paying	pay	VBG
cord-000238-om92cx5q	221	29	the	the	DT
cord-000238-om92cx5q	221	30	rent	rent	NN
cord-000238-om92cx5q	221	31	"	"	''
cord-000238-om92cx5q	221	32	to	to	IN
cord-000238-om92cx5q	221	33	their	-PRON-	PRP$
cord-000238-om92cx5q	221	34	bacterial	bacterial	JJ
cord-000238-om92cx5q	221	35	hosts	host	NNS
cord-000238-om92cx5q	221	36	,	,	,
cord-000238-om92cx5q	221	37	as	as	IN
cord-000238-om92cx5q	221	38	plasmids	plasmid	NNS
cord-000238-om92cx5q	221	39	can	can	MD
cord-000238-om92cx5q	221	40	not	not	RB
cord-000238-om92cx5q	221	41	easily	easily	RB
cord-000238-om92cx5q	221	42	control	control	VB
cord-000238-om92cx5q	221	43	the	the	DT
cord-000238-om92cx5q	221	44	host	host	NN
cord-000238-om92cx5q	221	45	backgrounds	background	NNS
cord-000238-om92cx5q	221	46	and	and	CC
cord-000238-om92cx5q	221	47	environments	environment	NNS
cord-000238-om92cx5q	221	48	in	in	IN
cord-000238-om92cx5q	221	49	which	which	WDT
cord-000238-om92cx5q	221	50	they	-PRON-	PRP
cord-000238-om92cx5q	221	51	reside	reside	VBP
cord-000238-om92cx5q	221	52	.	.	.
cord-000238-om92cx5q	222	1	Last	last	RB
cord-000238-om92cx5q	222	2	,	,	,
cord-000238-om92cx5q	222	3	selection	selection	NN
cord-000238-om92cx5q	222	4	may	may	MD
cord-000238-om92cx5q	222	5	be	be	VB
cord-000238-om92cx5q	222	6	acting	act	VBG
cord-000238-om92cx5q	222	7	on	on	IN
cord-000238-om92cx5q	222	8	the	the	DT
cord-000238-om92cx5q	222	9	symbiotic	symbiotic	JJ
cord-000238-om92cx5q	222	10	microbe	microbe	NN
cord-000238-om92cx5q	222	11	created	create	VBN
cord-000238-om92cx5q	222	12	through	through	IN
cord-000238-om92cx5q	222	13	plasmid	plasmid	NN
cord-000238-om92cx5q	222	14	/	/	SYM
cord-000238-om92cx5q	222	15	cell	cell	NNP
cord-000238-om92cx5q	222	16	association	association	NNP
cord-000238-om92cx5q	222	17	,	,	,
cord-000238-om92cx5q	222	18	where	where	WRB
cord-000238-om92cx5q	222	19	the	the	DT
cord-000238-om92cx5q	222	20	combined	combined	JJ
cord-000238-om92cx5q	222	21	interests	interest	NNS
cord-000238-om92cx5q	222	22	of	of	IN
cord-000238-om92cx5q	222	23	plasmids	plasmid	NNS
cord-000238-om92cx5q	222	24	and	and	CC
cord-000238-om92cx5q	222	25	their	-PRON-	PRP$
cord-000238-om92cx5q	222	26	hosts	host	NNS
cord-000238-om92cx5q	222	27	may	may	MD
cord-000238-om92cx5q	222	28	sometimes	sometimes	RB
cord-000238-om92cx5q	222	29	coincide	coincide	VB
cord-000238-om92cx5q	222	30	and	and	CC
cord-000238-om92cx5q	222	31	other	other	JJ
cord-000238-om92cx5q	222	32	times	time	NNS
cord-000238-om92cx5q	222	33	conflict	conflict	NN
cord-000238-om92cx5q	222	34	.	.	.
cord-000238-om92cx5q	223	1	Regardless	regardless	RB
cord-000238-om92cx5q	223	2	,	,	,
cord-000238-om92cx5q	223	3	environmentally	environmentally	RB
cord-000238-om92cx5q	223	4	robust	robust	JJ
cord-000238-om92cx5q	223	5	bacterial	bacterial	JJ
cord-000238-om92cx5q	223	6	pathogens	pathogen	NNS
cord-000238-om92cx5q	223	7	of	of	IN
cord-000238-om92cx5q	223	8	humans	human	NNS
cord-000238-om92cx5q	223	9	must	must	MD
cord-000238-om92cx5q	223	10	have	have	VB
cord-000238-om92cx5q	223	11	been	be	VBN
cord-000238-om92cx5q	223	12	selectively	selectively	RB
cord-000238-om92cx5q	223	13	favored	favor	VBN
cord-000238-om92cx5q	223	14	during	during	IN
cord-000238-om92cx5q	223	15	the	the	DT
cord-000238-om92cx5q	223	16	past	past	JJ
cord-000238-om92cx5q	223	17	halfcentury	halfcentury	NNP
cord-000238-om92cx5q	223	18	,	,	,
cord-000238-om92cx5q	223	19	or	or	CC
cord-000238-om92cx5q	223	20	the	the	DT
cord-000238-om92cx5q	223	21	ineffectiveness	ineffectiveness	NN
cord-000238-om92cx5q	223	22	of	of	IN
cord-000238-om92cx5q	223	23	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	223	24	therapy	therapy	NN
cord-000238-om92cx5q	223	25	would	would	MD
cord-000238-om92cx5q	223	26	not	not	RB
cord-000238-om92cx5q	223	27	be	be	VB
cord-000238-om92cx5q	223	28	a	a	DT
cord-000238-om92cx5q	223	29	prominent	prominent	JJ
cord-000238-om92cx5q	223	30	issue	issue	NN
cord-000238-om92cx5q	223	31	today	today	NN
cord-000238-om92cx5q	223	32	.	.	.
cord-000238-om92cx5q	224	1	The	the	DT
cord-000238-om92cx5q	224	2	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	224	3	consequences	consequence	NNS
cord-000238-om92cx5q	224	4	of	of	IN
cord-000238-om92cx5q	224	5	environmental	environmental	JJ
cord-000238-om92cx5q	224	6	robustness	robustness	NN
cord-000238-om92cx5q	224	7	in	in	IN
cord-000238-om92cx5q	224	8	resistant	resistant	JJ
cord-000238-om92cx5q	224	9	bacteria	bacteria	NNS
cord-000238-om92cx5q	224	10	have	have	VBP
cord-000238-om92cx5q	224	11	not	not	RB
cord-000238-om92cx5q	224	12	been	be	VBN
cord-000238-om92cx5q	224	13	widely	widely	RB
cord-000238-om92cx5q	224	14	addressed	address	VBN
cord-000238-om92cx5q	224	15	.	.	.
cord-000238-om92cx5q	225	1	Bacteria	Bacteria	NNS
cord-000238-om92cx5q	225	2	able	able	JJ
cord-000238-om92cx5q	225	3	to	to	TO
cord-000238-om92cx5q	225	4	robustly	robustly	RB
cord-000238-om92cx5q	225	5	grow	grow	VB
cord-000238-om92cx5q	225	6	in	in	IN
cord-000238-om92cx5q	225	7	a	a	DT
cord-000238-om92cx5q	225	8	variety	variety	NN
cord-000238-om92cx5q	225	9	of	of	IN
cord-000238-om92cx5q	225	10	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	225	11	environments	environment	NNS
cord-000238-om92cx5q	225	12	are	be	VBP
cord-000238-om92cx5q	225	13	generalists	generalist	NNS
cord-000238-om92cx5q	225	14	according	accord	VBG
cord-000238-om92cx5q	225	15	to	to	IN
cord-000238-om92cx5q	225	16	the	the	DT
cord-000238-om92cx5q	225	17	ecological	ecological	JJ
cord-000238-om92cx5q	225	18	definition	definition	NN
cord-000238-om92cx5q	225	19	of	of	IN
cord-000238-om92cx5q	225	20	niche	niche	NN
cord-000238-om92cx5q	225	21	breadth	breadth	NN
cord-000238-om92cx5q	225	22	.	.	.
cord-000238-om92cx5q	226	1	This	this	DT
cord-000238-om92cx5q	226	2	niche	niche	NN
cord-000238-om92cx5q	226	3	breadth	breadth	NN
cord-000238-om92cx5q	226	4	may	may	MD
cord-000238-om92cx5q	226	5	have	have	VB
cord-000238-om92cx5q	226	6	been	be	VBN
cord-000238-om92cx5q	226	7	directly	directly	RB
cord-000238-om92cx5q	226	8	molded	mold	VBN
cord-000238-om92cx5q	226	9	through	through	IN
cord-000238-om92cx5q	226	10	selection	selection	NN
cord-000238-om92cx5q	226	11	if	if	IN
cord-000238-om92cx5q	226	12	the	the	DT
cord-000238-om92cx5q	226	13	bacteria	bacteria	NNS
cord-000238-om92cx5q	226	14	descended	descend	VBD
cord-000238-om92cx5q	226	15	from	from	IN
cord-000238-om92cx5q	226	16	a	a	DT
cord-000238-om92cx5q	226	17	lineage	lineage	NN
cord-000238-om92cx5q	226	18	exposed	expose	VBN
cord-000238-om92cx5q	226	19	to	to	IN
cord-000238-om92cx5q	226	20	the	the	DT
cord-000238-om92cx5q	226	21	various	various	JJ
cord-000238-om92cx5q	226	22	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	226	23	.	.	.
cord-000238-om92cx5q	227	1	Alternatively	alternatively	RB
cord-000238-om92cx5q	227	2	,	,	,
cord-000238-om92cx5q	227	3	the	the	DT
cord-000238-om92cx5q	227	4	niche	niche	NN
cord-000238-om92cx5q	227	5	breadth	breadth	NN
cord-000238-om92cx5q	227	6	may	may	MD
cord-000238-om92cx5q	227	7	be	be	VB
cord-000238-om92cx5q	227	8	fortuitous	fortuitous	JJ
cord-000238-om92cx5q	227	9	if	if	IN
cord-000238-om92cx5q	227	10	the	the	DT
cord-000238-om92cx5q	227	11	bacteria	bacteria	NNS
cord-000238-om92cx5q	227	12	obtained	obtain	VBD
cord-000238-om92cx5q	227	13	a	a	DT
cord-000238-om92cx5q	227	14	plasmid	plasmid	NN
cord-000238-om92cx5q	227	15	harboring	harbor	VBG
cord-000238-om92cx5q	227	16	multiple	multiple	JJ
cord-000238-om92cx5q	227	17	-	-	HYPH
cord-000238-om92cx5q	227	18	resistance	resistance	NN
cord-000238-om92cx5q	227	19	genes	gene	NNS
cord-000238-om92cx5q	227	20	that	that	WDT
cord-000238-om92cx5q	227	21	ran	run	VBD
cord-000238-om92cx5q	227	22	the	the	DT
cord-000238-om92cx5q	227	23	gauntlet	gauntlet	NN
cord-000238-om92cx5q	227	24	of	of	IN
cord-000238-om92cx5q	227	25	selection	selection	NN
cord-000238-om92cx5q	227	26	in	in	IN
cord-000238-om92cx5q	227	27	other	other	JJ
cord-000238-om92cx5q	227	28	contexts	context	NNS
cord-000238-om92cx5q	227	29	.	.	.
cord-000238-om92cx5q	228	1	No	no	RB
cord-000238-om92cx5q	228	2	matter	matter	RB
cord-000238-om92cx5q	228	3	the	the	DT
cord-000238-om92cx5q	228	4	circumstance	circumstance	NN
cord-000238-om92cx5q	228	5	,	,	,
cord-000238-om92cx5q	228	6	we	-PRON-	PRP
cord-000238-om92cx5q	228	7	noted	note	VBD
cord-000238-om92cx5q	228	8	above	above	IN
cord-000238-om92cx5q	228	9	that	that	DT
cord-000238-om92cx5q	229	1	some	some	DT
cord-000238-om92cx5q	229	2	theory	theory	NN
cord-000238-om92cx5q	229	3	predicts	predict	VBZ
cord-000238-om92cx5q	229	4	evolved	evolved	JJ
cord-000238-om92cx5q	229	5	generalization	generalization	NN
cord-000238-om92cx5q	229	6	may	may	MD
cord-000238-om92cx5q	229	7	be	be	VB
cord-000238-om92cx5q	229	8	particularly	particularly	RB
cord-000238-om92cx5q	229	9	useful	useful	JJ
cord-000238-om92cx5q	229	10	if	if	IN
cord-000238-om92cx5q	229	11	organisms	organism	NNS
cord-000238-om92cx5q	229	12	tend	tend	VBP
cord-000238-om92cx5q	229	13	to	to	TO
cord-000238-om92cx5q	229	14	encounter	encounter	VB
cord-000238-om92cx5q	229	15	highly	highly	RB
cord-000238-om92cx5q	229	16	variable	variable	JJ
cord-000238-om92cx5q	229	17	environments	environment	NNS
cord-000238-om92cx5q	229	18	.	.	.
cord-000238-om92cx5q	230	1	41	41	CD
cord-000238-om92cx5q	231	1	The	the	DT
cord-000238-om92cx5q	231	2	phenomenon	phenomenon	NN
cord-000238-om92cx5q	231	3	of	of	IN
cord-000238-om92cx5q	231	4	drug	drug	NN
cord-000238-om92cx5q	231	5	cross	cross	NN
cord-000238-om92cx5q	231	6	-	-	NN
cord-000238-om92cx5q	231	7	resistance	resistance	NN
cord-000238-om92cx5q	231	8	and	and	CC
cord-000238-om92cx5q	231	9	possible	possible	JJ
cord-000238-om92cx5q	231	10	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	231	11	modification	modification	NN
cord-000238-om92cx5q	231	12	of	of	IN
cord-000238-om92cx5q	231	13	a	a	DT
cord-000238-om92cx5q	231	14	resistance	resistance	NN
cord-000238-om92cx5q	231	15	allele	allele	NN
cord-000238-om92cx5q	231	16	allowing	allow	VBG
cord-000238-om92cx5q	231	17	survival	survival	NN
cord-000238-om92cx5q	231	18	in	in	IN
cord-000238-om92cx5q	231	19	altered	altered	JJ
cord-000238-om92cx5q	231	20	circumstances	circumstance	NNS
cord-000238-om92cx5q	231	21	͑i.e	͑i.e	.
cord-000238-om92cx5q	231	22	.	.	.
cord-000238-om92cx5q	232	1	,	,	,
cord-000238-om92cx5q	232	2	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	232	3	innovation͒	innovation͒	NNP
cord-000238-om92cx5q	232	4	lend	lend	VB
cord-000238-om92cx5q	232	5	plausibility	plausibility	NN
cord-000238-om92cx5q	232	6	to	to	IN
cord-000238-om92cx5q	232	7	the	the	DT
cord-000238-om92cx5q	232	8	concept	concept	NN
cord-000238-om92cx5q	232	9	that	that	IN
cord-000238-om92cx5q	232	10	multiple	multiple	JJ
cord-000238-om92cx5q	232	11	-	-	HYPH
cord-000238-om92cx5q	232	12	resistance	resistance	NN
cord-000238-om92cx5q	232	13	strains	strain	NNS
cord-000238-om92cx5q	232	14	by	by	IN
cord-000238-om92cx5q	232	15	an	an	DT
cord-000238-om92cx5q	232	16	evolvability	evolvability	NN
cord-000238-om92cx5q	232	17	advantage	advantage	NN
cord-000238-om92cx5q	232	18	would	would	MD
cord-000238-om92cx5q	232	19	better	better	RB
cord-000238-om92cx5q	232	20	thrive	thrive	VB
cord-000238-om92cx5q	232	21	in	in	IN
cord-000238-om92cx5q	232	22	the	the	DT
cord-000238-om92cx5q	232	23	face	face	NN
cord-000238-om92cx5q	232	24	of	of	IN
cord-000238-om92cx5q	232	25	novel	novel	JJ
cord-000238-om92cx5q	232	26	drugs	drug	NNS
cord-000238-om92cx5q	232	27	.	.	.
cord-000238-om92cx5q	233	1	We	-PRON-	PRP
cord-000238-om92cx5q	233	2	are	be	VBP
cord-000238-om92cx5q	233	3	unaware	unaware	JJ
cord-000238-om92cx5q	233	4	of	of	IN
cord-000238-om92cx5q	233	5	any	any	DT
cord-000238-om92cx5q	233	6	studies	study	NNS
cord-000238-om92cx5q	233	7	addressing	address	VBG
cord-000238-om92cx5q	233	8	the	the	DT
cord-000238-om92cx5q	233	9	relationship	relationship	NN
cord-000238-om92cx5q	233	10	between	between	IN
cord-000238-om92cx5q	233	11	number	number	NN
cord-000238-om92cx5q	233	12	or	or	CC
cord-000238-om92cx5q	233	13	diversity	diversity	NN
cord-000238-om92cx5q	233	14	of	of	IN
cord-000238-om92cx5q	233	15	resistance	resistance	NN
cord-000238-om92cx5q	233	16	genes	gene	NNS
cord-000238-om92cx5q	233	17	in	in	IN
cord-000238-om92cx5q	233	18	bacteria	bacteria	NNS
cord-000238-om92cx5q	233	19	and	and	CC
cord-000238-om92cx5q	233	20	the	the	DT
cord-000238-om92cx5q	233	21	evolvability	evolvability	NN
cord-000238-om92cx5q	233	22	of	of	IN
cord-000238-om92cx5q	233	23	bacterial	bacterial	JJ
cord-000238-om92cx5q	233	24	pathogens	pathogen	NNS
cord-000238-om92cx5q	233	25	in	in	IN
cord-000238-om92cx5q	233	26	new	new	JJ
cord-000238-om92cx5q	233	27	environments	environment	NNS
cord-000238-om92cx5q	233	28	.	.	.
cord-000238-om92cx5q	234	1	Such	such	JJ
cord-000238-om92cx5q	234	2	research	research	NN
cord-000238-om92cx5q	234	3	would	would	MD
cord-000238-om92cx5q	234	4	be	be	VB
cord-000238-om92cx5q	234	5	highly	highly	RB
cord-000238-om92cx5q	234	6	useful	useful	JJ
cord-000238-om92cx5q	234	7	for	for	IN
cord-000238-om92cx5q	234	8	examining	examine	VBG
cord-000238-om92cx5q	234	9	the	the	DT
cord-000238-om92cx5q	234	10	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	234	11	processes	process	NNS
cord-000238-om92cx5q	234	12	underlying	underlie	VBG
cord-000238-om92cx5q	234	13	the	the	DT
cord-000238-om92cx5q	234	14	widespread	widespread	JJ
cord-000238-om92cx5q	234	15	success	success	NN
cord-000238-om92cx5q	234	16	of	of	IN
cord-000238-om92cx5q	234	17	resistant	resistant	JJ
cord-000238-om92cx5q	234	18	bacteria	bacteria	NNS
cord-000238-om92cx5q	234	19	.	.	.
cord-000238-om92cx5q	235	1	We	-PRON-	PRP
cord-000238-om92cx5q	235	2	note	note	VBP
cord-000238-om92cx5q	235	3	that	that	IN
cord-000238-om92cx5q	235	4	existing	exist	VBG
cord-000238-om92cx5q	235	5	data	datum	NNS
cord-000238-om92cx5q	235	6	already	already	RB
cord-000238-om92cx5q	235	7	suggest	suggest	VBP
cord-000238-om92cx5q	235	8	that	that	IN
cord-000238-om92cx5q	235	9	genetic	genetic	JJ
cord-000238-om92cx5q	235	10	robustness	robustness	NN
cord-000238-om92cx5q	235	11	is	be	VBZ
cord-000238-om92cx5q	235	12	relevant	relevant	JJ
cord-000238-om92cx5q	235	13	to	to	IN
cord-000238-om92cx5q	235	14	the	the	DT
cord-000238-om92cx5q	235	15	evolution	evolution	NN
cord-000238-om92cx5q	235	16	of	of	IN
cord-000238-om92cx5q	235	17	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	235	18	resistance	resistance	NN
cord-000238-om92cx5q	235	19	in	in	IN
cord-000238-om92cx5q	235	20	bacteria	bacteria	NNS
cord-000238-om92cx5q	235	21	.	.	.
cord-000238-om92cx5q	236	1	Research	research	NN
cord-000238-om92cx5q	236	2	shows	show	VBZ
cord-000238-om92cx5q	236	3	that	that	IN
cord-000238-om92cx5q	236	4	compensatory	compensatory	JJ
cord-000238-om92cx5q	236	5	mutation	mutation	NN
cord-000238-om92cx5q	236	6	is	be	VBZ
cord-000238-om92cx5q	236	7	an	an	DT
cord-000238-om92cx5q	236	8	important	important	JJ
cord-000238-om92cx5q	236	9	underlying	underlying	JJ
cord-000238-om92cx5q	236	10	genetic	genetic	JJ
cord-000238-om92cx5q	236	11	mechanism	mechanism	NN
cord-000238-om92cx5q	236	12	for	for	IN
cord-000238-om92cx5q	236	13	maintenance	maintenance	NN
cord-000238-om92cx5q	236	14	of	of	IN
cord-000238-om92cx5q	236	15	resistance	resistance	NN
cord-000238-om92cx5q	236	16	in	in	IN
cord-000238-om92cx5q	236	17	the	the	DT
cord-000238-om92cx5q	236	18	absence	absence	NN
cord-000238-om92cx5q	236	19	of	of	IN
cord-000238-om92cx5q	236	20	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	236	21	selection	selection	NN
cord-000238-om92cx5q	236	22	.	.	.
cord-000238-om92cx5q	237	1	53	53	CD
cord-000238-om92cx5q	238	1	This	this	DT
cord-000238-om92cx5q	238	2	epistasis	epistasis	NN
cord-000238-om92cx5q	238	3	mechanism	mechanism	NN
cord-000238-om92cx5q	238	4	explains	explain	VBZ
cord-000238-om92cx5q	238	5	how	how	WRB
cord-000238-om92cx5q	238	6	a	a	DT
cord-000238-om92cx5q	238	7	resistance	resistance	NN
cord-000238-om92cx5q	238	8	gene	gene	NN
cord-000238-om92cx5q	238	9	that	that	WDT
cord-000238-om92cx5q	238	10	is	be	VBZ
cord-000238-om92cx5q	238	11	costly	costly	JJ
cord-000238-om92cx5q	238	12	for	for	IN
cord-000238-om92cx5q	238	13	bacterial	bacterial	JJ
cord-000238-om92cx5q	238	14	growth	growth	NN
cord-000238-om92cx5q	238	15	in	in	IN
cord-000238-om92cx5q	238	16	absence	absence	NN
cord-000238-om92cx5q	238	17	of	of	IN
cord-000238-om92cx5q	238	18	an	an	DT
cord-000238-om92cx5q	238	19	antibiotic	antibiotic	NN
cord-000238-om92cx5q	238	20	may	may	MD
cord-000238-om92cx5q	238	21	be	be	VB
cord-000238-om92cx5q	238	22	compensated	compensate	VBN
cord-000238-om92cx5q	238	23	by	by	IN
cord-000238-om92cx5q	238	24	one	one	CD
cord-000238-om92cx5q	238	25	or	or	CC
cord-000238-om92cx5q	238	26	more	more	JJR
cord-000238-om92cx5q	238	27	mutations	mutation	NNS
cord-000238-om92cx5q	238	28	in	in	IN
cord-000238-om92cx5q	238	29	the	the	DT
cord-000238-om92cx5q	238	30	plasmid	plasmid	NN
cord-000238-om92cx5q	238	31	or	or	CC
cord-000238-om92cx5q	238	32	bacterial	bacterial	JJ
cord-000238-om92cx5q	238	33	chromosome	chromosome	NN
cord-000238-om92cx5q	238	34	,	,	,
cord-000238-om92cx5q	238	35	effectively	effectively	RB
cord-000238-om92cx5q	238	36	eliminating	eliminate	VBG
cord-000238-om92cx5q	238	37	the	the	DT
cord-000238-om92cx5q	238	38	cost	cost	NN
cord-000238-om92cx5q	238	39	of	of	IN
cord-000238-om92cx5q	238	40	carrying	carry	VBG
cord-000238-om92cx5q	238	41	the	the	DT
cord-000238-om92cx5q	238	42	resistance	resistance	NN
cord-000238-om92cx5q	238	43	gene	gene	NN
cord-000238-om92cx5q	238	44	͑or	͑or	VBZ
cord-000238-om92cx5q	238	45	the	the	DT
cord-000238-om92cx5q	238	46	plasmid	plasmid	NN
cord-000238-om92cx5q	238	47	on	on	IN
cord-000238-om92cx5q	238	48	which	which	WDT
cord-000238-om92cx5q	238	49	it	-PRON-	PRP
cord-000238-om92cx5q	238	50	re	re	VBD
cord-000238-om92cx5q	238	51	-	-	JJ
cord-000238-om92cx5q	238	52	sides͒	sides͒	JJ
cord-000238-om92cx5q	238	53	when	when	WRB
cord-000238-om92cx5q	238	54	no	no	DT
cord-000238-om92cx5q	238	55	antibiotic	antibiotic	NN
cord-000238-om92cx5q	238	56	is	be	VBZ
cord-000238-om92cx5q	238	57	present	present	JJ
cord-000238-om92cx5q	238	58	.	.	.
cord-000238-om92cx5q	239	1	If	if	IN
cord-000238-om92cx5q	239	2	a	a	DT
cord-000238-om92cx5q	239	3	bacterial	bacterial	JJ
cord-000238-om92cx5q	239	4	strain	strain	NN
cord-000238-om92cx5q	239	5	contains	contain	VBZ
cord-000238-om92cx5q	239	6	a	a	DT
cord-000238-om92cx5q	239	7	compensatory	compensatory	JJ
cord-000238-om92cx5q	239	8	mutation	mutation	NN
cord-000238-om92cx5q	239	9	that	that	WDT
cord-000238-om92cx5q	239	10	interacts	interact	VBZ
cord-000238-om92cx5q	239	11	to	to	TO
cord-000238-om92cx5q	239	12	reduce	reduce	VB
cord-000238-om92cx5q	239	13	the	the	DT
cord-000238-om92cx5q	239	14	cost	cost	NN
cord-000238-om92cx5q	239	15	of	of	IN
cord-000238-om92cx5q	239	16	various	various	JJ
cord-000238-om92cx5q	239	17	different	different	JJ
cord-000238-om92cx5q	239	18	resistance	resistance	NN
cord-000238-om92cx5q	239	19	genes	gene	NNS
cord-000238-om92cx5q	239	20	,	,	,
cord-000238-om92cx5q	239	21	then	then	RB
cord-000238-om92cx5q	239	22	this	this	DT
cord-000238-om92cx5q	239	23	epistatic	epistatic	JJ
cord-000238-om92cx5q	239	24	mutation	mutation	NN
cord-000238-om92cx5q	239	25	would	would	MD
cord-000238-om92cx5q	239	26	provide	provide	VB
cord-000238-om92cx5q	239	27	an	an	DT
cord-000238-om92cx5q	239	28	example	example	NN
cord-000238-om92cx5q	239	29	of	of	IN
cord-000238-om92cx5q	239	30	a	a	DT
cord-000238-om92cx5q	239	31	genetic	genetic	JJ
cord-000238-om92cx5q	239	32	-	-	HYPH
cord-000238-om92cx5q	239	33	robustness	robustness	NN
cord-000238-om92cx5q	239	34	allele	allele	NN
cord-000238-om92cx5q	239	35	responsible	responsible	JJ
cord-000238-om92cx5q	239	36	for	for	IN
cord-000238-om92cx5q	239	37	environmental	environmental	JJ
cord-000238-om92cx5q	239	38	robustness	robustness	NN
cord-000238-om92cx5q	239	39	across	across	IN
cord-000238-om92cx5q	239	40	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	239	41	environments	environment	NNS
cord-000238-om92cx5q	239	42	.	.	.
cord-000238-om92cx5q	240	1	For	for	IN
cord-000238-om92cx5q	240	2	example	example	NN
cord-000238-om92cx5q	240	3	,	,	,
cord-000238-om92cx5q	240	4	the	the	DT
cord-000238-om92cx5q	240	5	multiple	multiple	JJ
cord-000238-om92cx5q	240	6	antibiotic	antibiotic	JJ
cord-000238-om92cx5q	240	7	resistance	resistance	NN
cord-000238-om92cx5q	240	8	locus	locus	NN
cord-000238-om92cx5q	240	9	in	in	IN
cord-000238-om92cx5q	240	10	E.	E.	NNP
cord-000238-om92cx5q	240	11	coli	coli	NNS
cord-000238-om92cx5q	240	12	and	and	CC
cord-000238-om92cx5q	240	13	several	several	JJ
cord-000238-om92cx5q	240	14	species	specie	NNS
cord-000238-om92cx5q	240	15	of	of	IN
cord-000238-om92cx5q	240	16	Salmonella	Salmonella	NNP
cord-000238-om92cx5q	240	17	is	be	VBZ
cord-000238-om92cx5q	240	18	involved	involve	VBN
cord-000238-om92cx5q	240	19	with	with	IN
cord-000238-om92cx5q	240	20	production	production	NN
cord-000238-om92cx5q	240	21	of	of	IN
cord-000238-om92cx5q	240	22	an	an	DT
cord-000238-om92cx5q	240	23	efflux	efflux	NN
cord-000238-om92cx5q	240	24	pump	pump	NN
cord-000238-om92cx5q	240	25	that	that	WDT
cord-000238-om92cx5q	240	26	removes	remove	VBZ
cord-000238-om92cx5q	240	27	various	various	JJ
cord-000238-om92cx5q	240	28	antibiotics	antibiotic	NNS
cord-000238-om92cx5q	240	29	from	from	IN
cord-000238-om92cx5q	240	30	the	the	DT
cord-000238-om92cx5q	240	31	cell	cell	NN
cord-000238-om92cx5q	240	32	,	,	,
cord-000238-om92cx5q	240	33	affording	afford	VBG
cord-000238-om92cx5q	240	34	low	low	JJ
cord-000238-om92cx5q	240	35	-	-	HYPH
cord-000238-om92cx5q	240	36	level	level	NN
cord-000238-om92cx5q	240	37	clinical	clinical	JJ
cord-000238-om92cx5q	240	38	resistance	resistance	NN
cord-000238-om92cx5q	240	39	.	.	.
cord-000238-om92cx5q	241	1	54	54	CD
cord-000238-om92cx5q	242	1	However	however	RB
cord-000238-om92cx5q	242	2	,	,	,
cord-000238-om92cx5q	242	3	this	this	DT
cord-000238-om92cx5q	242	4	mode	mode	NN
cord-000238-om92cx5q	242	5	of	of	IN
cord-000238-om92cx5q	242	6	resistance	resistance	NN
cord-000238-om92cx5q	242	7	can	can	MD
cord-000238-om92cx5q	242	8	be	be	VB
cord-000238-om92cx5q	242	9	rather	rather	RB
cord-000238-om92cx5q	242	10	costly	costly	JJ
cord-000238-om92cx5q	242	11	if	if	IN
cord-000238-om92cx5q	242	12	transport	transport	NN
cord-000238-om92cx5q	242	13	in	in	IN
cord-000238-om92cx5q	242	14	and	and	CC
cord-000238-om92cx5q	242	15	out	out	IN
cord-000238-om92cx5q	242	16	of	of	IN
cord-000238-om92cx5q	242	17	the	the	DT
cord-000238-om92cx5q	242	18	cell	cell	NN
cord-000238-om92cx5q	242	19	is	be	VBZ
cord-000238-om92cx5q	242	20	not	not	RB
cord-000238-om92cx5q	242	21	tightly	tightly	RB
cord-000238-om92cx5q	242	22	regulated	regulate	VBN
cord-000238-om92cx5q	242	23	.	.	.
cord-000238-om92cx5q	243	1	Evidence	evidence	NN
cord-000238-om92cx5q	243	2	suggests	suggest	VBZ
cord-000238-om92cx5q	243	3	that	that	IN
cord-000238-om92cx5q	243	4	the	the	DT
cord-000238-om92cx5q	243	5	low	low	JJ
cord-000238-om92cx5q	243	6	-	-	HYPH
cord-000238-om92cx5q	243	7	level	level	NN
cord-000238-om92cx5q	243	8	resistance	resistance	NN
cord-000238-om92cx5q	243	9	may	may	MD
cord-000238-om92cx5q	243	10	be	be	VB
cord-000238-om92cx5q	243	11	a	a	DT
cord-000238-om92cx5q	243	12	stepping	stepping	JJ
cord-000238-om92cx5q	243	13	-	-	HYPH
cord-000238-om92cx5q	243	14	stone	stone	NN
cord-000238-om92cx5q	243	15	to	to	IN
cord-000238-om92cx5q	243	16	more	more	RBR
cord-000238-om92cx5q	243	17	finely	finely	RB
cord-000238-om92cx5q	243	18	tuned	tune	VBN
cord-000238-om92cx5q	243	19	evolved	evolve	VBN
cord-000238-om92cx5q	243	20	mechanisms	mechanism	NNS
cord-000238-om92cx5q	243	21	allowing	allow	VBG
cord-000238-om92cx5q	243	22	greater	great	JJR
cord-000238-om92cx5q	243	23	resistance	resistance	NN
cord-000238-om92cx5q	243	24	,	,	,
cord-000238-om92cx5q	243	25	55	55	CD
cord-000238-om92cx5q	243	26	and	and	CC
cord-000238-om92cx5q	243	27	we	-PRON-	PRP
cord-000238-om92cx5q	243	28	can	can	MD
cord-000238-om92cx5q	243	29	conceive	conceive	VB
cord-000238-om92cx5q	243	30	that	that	IN
cord-000238-om92cx5q	243	31	genetic	genetic	JJ
cord-000238-om92cx5q	243	32	changes	change	NNS
cord-000238-om92cx5q	243	33	simultaneously	simultaneously	RB
cord-000238-om92cx5q	243	34	compensating	compensate	VBG
cord-000238-om92cx5q	243	35	to	to	TO
cord-000238-om92cx5q	243	36	reduce	reduce	VB
cord-000238-om92cx5q	243	37	the	the	DT
cord-000238-om92cx5q	243	38	cost	cost	NN
cord-000238-om92cx5q	243	39	while	while	IN
cord-000238-om92cx5q	243	40	maintaining	maintain	VBG
cord-000238-om92cx5q	243	41	the	the	DT
cord-000238-om92cx5q	243	42	broad	broad	JJ
cord-000238-om92cx5q	243	43	resistance	resistance	NN
cord-000238-om92cx5q	243	44	would	would	MD
cord-000238-om92cx5q	243	45	provide	provide	VB
cord-000238-om92cx5q	243	46	an	an	DT
cord-000238-om92cx5q	243	47	example	example	NN
cord-000238-om92cx5q	243	48	of	of	IN
cord-000238-om92cx5q	243	49	a	a	DT
cord-000238-om92cx5q	243	50	genetic	genetic	JJ
cord-000238-om92cx5q	243	51	-	-	HYPH
cord-000238-om92cx5q	243	52	robustness	robustness	NN
cord-000238-om92cx5q	243	53	allele	allele	NN
cord-000238-om92cx5q	243	54	.	.	.
cord-000238-om92cx5q	244	1	Many	many	JJ
cord-000238-om92cx5q	244	2	of	of	IN
cord-000238-om92cx5q	244	3	the	the	DT
cord-000238-om92cx5q	244	4	above	above	JJ
cord-000238-om92cx5q	244	5	studies	study	NNS
cord-000238-om92cx5q	244	6	suggest	suggest	VBP
cord-000238-om92cx5q	244	7	ways	way	NNS
cord-000238-om92cx5q	244	8	that	that	WDT
cord-000238-om92cx5q	244	9	robustness	robustness	NN
cord-000238-om92cx5q	244	10	might	may	MD
cord-000238-om92cx5q	244	11	play	play	VB
cord-000238-om92cx5q	244	12	a	a	DT
cord-000238-om92cx5q	244	13	role	role	NN
cord-000238-om92cx5q	244	14	in	in	IN
cord-000238-om92cx5q	244	15	disease	disease	NN
cord-000238-om92cx5q	244	16	pathogenesis	pathogenesis	NN
cord-000238-om92cx5q	244	17	and	and	CC
cord-000238-om92cx5q	244	18	treatment	treatment	NN
cord-000238-om92cx5q	244	19	efficacy	efficacy	NN
cord-000238-om92cx5q	244	20	,	,	,
cord-000238-om92cx5q	244	21	and	and	CC
cord-000238-om92cx5q	244	22	how	how	WRB
cord-000238-om92cx5q	244	23	robustness	robustness	NN
cord-000238-om92cx5q	244	24	might	may	MD
cord-000238-om92cx5q	244	25	be	be	VB
cord-000238-om92cx5q	244	26	linked	link	VBN
cord-000238-om92cx5q	244	27	to	to	IN
cord-000238-om92cx5q	244	28	emergence	emergence	NN
cord-000238-om92cx5q	244	29	of	of	IN
cord-000238-om92cx5q	244	30	future	future	JJ
cord-000238-om92cx5q	244	31	viral	viral	JJ
cord-000238-om92cx5q	244	32	diseases	disease	NNS
cord-000238-om92cx5q	244	33	in	in	IN
cord-000238-om92cx5q	244	34	humans	human	NNS
cord-000238-om92cx5q	244	35	.	.	.
cord-000238-om92cx5q	245	1	However	however	RB
cord-000238-om92cx5q	245	2	,	,	,
cord-000238-om92cx5q	245	3	contemporary	contemporary	JJ
cord-000238-om92cx5q	245	4	examples	example	NNS
cord-000238-om92cx5q	245	5	already	already	RB
cord-000238-om92cx5q	245	6	indicate	indicate	VBP
cord-000238-om92cx5q	245	7	that	that	IN
cord-000238-om92cx5q	245	8	robustness	robustness	NN
cord-000238-om92cx5q	245	9	theory	theory	NN
cord-000238-om92cx5q	245	10	is	be	VBZ
cord-000238-om92cx5q	245	11	helpful	helpful	JJ
cord-000238-om92cx5q	245	12	in	in	IN
cord-000238-om92cx5q	245	13	elucidating	elucidate	VBG
cord-000238-om92cx5q	245	14	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	245	15	dynamics	dynamic	NNS
cord-000238-om92cx5q	245	16	of	of	IN
cord-000238-om92cx5q	245	17	important	important	JJ
cord-000238-om92cx5q	245	18	RNA	RNA	NNP
cord-000238-om92cx5q	245	19	virus	virus	NN
cord-000238-om92cx5q	245	20	diseases	disease	NNS
cord-000238-om92cx5q	245	21	.	.	.
cord-000238-om92cx5q	246	1	One	one	CD
cord-000238-om92cx5q	246	2	example	example	NN
cord-000238-om92cx5q	246	3	is	be	VBZ
cord-000238-om92cx5q	246	4	the	the	DT
cord-000238-om92cx5q	246	5	occurrence	occurrence	NN
cord-000238-om92cx5q	246	6	of	of	IN
cord-000238-om92cx5q	246	7	flu	flu	NN
cord-000238-om92cx5q	246	8	pandemics	pandemic	NNS
cord-000238-om92cx5q	246	9	in	in	IN
cord-000238-om92cx5q	246	10	humans	human	NNS
cord-000238-om92cx5q	246	11	,	,	,
cord-000238-om92cx5q	246	12	a	a	DT
cord-000238-om92cx5q	246	13	substantial	substantial	JJ
cord-000238-om92cx5q	246	14	public	public	JJ
cord-000238-om92cx5q	246	15	health	health	NN
cord-000238-om92cx5q	246	16	concern	concern	NN
cord-000238-om92cx5q	246	17	in	in	IN
cord-000238-om92cx5q	246	18	the	the	DT
cord-000238-om92cx5q	246	19	last	last	JJ
cord-000238-om92cx5q	246	20	century	century	NN
cord-000238-om92cx5q	246	21	.	.	.
cord-000238-om92cx5q	247	1	Recent	recent	JJ
cord-000238-om92cx5q	247	2	studies	study	NNS
cord-000238-om92cx5q	247	3	suggest	suggest	VBP
cord-000238-om92cx5q	247	4	that	that	IN
cord-000238-om92cx5q	247	5	strains	strain	NNS
cord-000238-om92cx5q	247	6	of	of	IN
cord-000238-om92cx5q	247	7	influenza	influenza	NN
cord-000238-om92cx5q	247	8	A	a	DT
cord-000238-om92cx5q	247	9	virus	virus	NN
cord-000238-om92cx5q	247	10	can	can	MD
cord-000238-om92cx5q	247	11	spread	spread	VB
cord-000238-om92cx5q	247	12	through	through	IN
cord-000238-om92cx5q	247	13	human	human	JJ
cord-000238-om92cx5q	247	14	populations	population	NNS
cord-000238-om92cx5q	247	15	because	because	IN
cord-000238-om92cx5q	247	16	they	-PRON-	PRP
cord-000238-om92cx5q	247	17	form	form	VBP
cord-000238-om92cx5q	247	18	a	a	DT
cord-000238-om92cx5q	247	19	neutral	neutral	JJ
cord-000238-om92cx5q	247	20	network	network	NN
cord-000238-om92cx5q	247	21	of	of	IN
cord-000238-om92cx5q	247	22	virus	virus	NN
cord-000238-om92cx5q	247	23	genotypes	genotype	NNS
cord-000238-om92cx5q	247	24	that	that	WDT
cord-000238-om92cx5q	247	25	share	share	VBP
cord-000238-om92cx5q	247	26	the	the	DT
cord-000238-om92cx5q	247	27	same	same	JJ
cord-000238-om92cx5q	247	28	phenotype	phenotype	NN
cord-000238-om92cx5q	247	29	.	.	.
cord-000238-om92cx5q	248	1	55	55	CD
cord-000238-om92cx5q	248	2	,	,	,
cord-000238-om92cx5q	248	3	56	56	CD
cord-000238-om92cx5q	249	1	Essentially	essentially	RB
cord-000238-om92cx5q	249	2	,	,	,
cord-000238-om92cx5q	249	3	this	this	DT
cord-000238-om92cx5q	249	4	network	network	NN
cord-000238-om92cx5q	249	5	allows	allow	VBZ
cord-000238-om92cx5q	249	6	the	the	DT
cord-000238-om92cx5q	249	7	virus	virus	NN
cord-000238-om92cx5q	249	8	to	to	TO
cord-000238-om92cx5q	249	9	drift	drift	VB
cord-000238-om92cx5q	249	10	through	through	IN
cord-000238-om92cx5q	249	11	neutral	neutral	JJ
cord-000238-om92cx5q	249	12	space	space	NN
cord-000238-om92cx5q	249	13	connected	connect	VBN
cord-000238-om92cx5q	249	14	via	via	IN
cord-000238-om92cx5q	249	15	mutation	mutation	NN
cord-000238-om92cx5q	249	16	,	,	,
cord-000238-om92cx5q	249	17	until	until	IN
cord-000238-om92cx5q	249	18	a	a	DT
cord-000238-om92cx5q	249	19	single	single	JJ
cord-000238-om92cx5q	249	20	mutation	mutation	NN
cord-000238-om92cx5q	249	21	shifts	shift	NNS
cord-000238-om92cx5q	249	22	to	to	IN
cord-000238-om92cx5q	249	23	a	a	DT
cord-000238-om92cx5q	249	24	different	different	JJ
cord-000238-om92cx5q	249	25	serotype	serotype	NN
cord-000238-om92cx5q	249	26	͑Fig	͑fig	NN
cord-000238-om92cx5q	249	27	.	.	.
cord-000238-om92cx5q	250	1	3͒.	3͒.	CD
cord-000238-om92cx5q	251	1	This	this	DT
cord-000238-om92cx5q	251	2	shift	shift	NN
cord-000238-om92cx5q	251	3	then	then	RB
cord-000238-om92cx5q	251	4	facilitates	facilitate	VBZ
cord-000238-om92cx5q	251	5	escape	escape	NN
cord-000238-om92cx5q	251	6	from	from	IN
cord-000238-om92cx5q	251	7	host	host	NN
cord-000238-om92cx5q	251	8	immunity	immunity	NN
cord-000238-om92cx5q	251	9	,	,	,
cord-000238-om92cx5q	251	10	and	and	CC
cord-000238-om92cx5q	251	11	fosters	foster	VBZ
cord-000238-om92cx5q	251	12	the	the	DT
cord-000238-om92cx5q	251	13	ability	ability	NN
cord-000238-om92cx5q	251	14	for	for	IN
cord-000238-om92cx5q	251	15	the	the	DT
cord-000238-om92cx5q	251	16	virus	virus	NN
cord-000238-om92cx5q	251	17	to	to	TO
cord-000238-om92cx5q	251	18	infect	infect	VB
cord-000238-om92cx5q	251	19	a	a	DT
cord-000238-om92cx5q	251	20	new	new	JJ
cord-000238-om92cx5q	251	21	class	class	NN
cord-000238-om92cx5q	251	22	of	of	IN
cord-000238-om92cx5q	251	23	susceptible	susceptible	JJ
cord-000238-om92cx5q	251	24	hosts	host	NNS
cord-000238-om92cx5q	251	25	.	.	.
cord-000238-om92cx5q	252	1	Although	although	IN
cord-000238-om92cx5q	252	2	these	these	DT
cord-000238-om92cx5q	252	3	studies	study	NNS
cord-000238-om92cx5q	252	4	make	make	VBP
cord-000238-om92cx5q	252	5	no	no	DT
cord-000238-om92cx5q	252	6	explicit	explicit	JJ
cord-000238-om92cx5q	252	7	mention	mention	NN
cord-000238-om92cx5q	252	8	of	of	IN
cord-000238-om92cx5q	252	9	the	the	DT
cord-000238-om92cx5q	252	10	role	role	NN
cord-000238-om92cx5q	252	11	of	of	IN
cord-000238-om92cx5q	252	12	such	such	JJ
cord-000238-om92cx5q	252	13	genetic	genetic	JJ
cord-000238-om92cx5q	252	14	robustness	robustness	NN
cord-000238-om92cx5q	252	15	in	in	IN
cord-000238-om92cx5q	252	16	flu	flu	NN
cord-000238-om92cx5q	252	17	epidemics	epidemic	NNS
cord-000238-om92cx5q	252	18	,	,	,
cord-000238-om92cx5q	252	19	55,56	55,56	CD
cord-000238-om92cx5q	252	20	the	the	DT
cord-000238-om92cx5q	252	21	available	available	JJ
cord-000238-om92cx5q	252	22	evidence	evidence	NN
cord-000238-om92cx5q	252	23	strongly	strongly	RB
cord-000238-om92cx5q	252	24	suggests	suggest	VBZ
cord-000238-om92cx5q	252	25	that	that	IN
cord-000238-om92cx5q	252	26	the	the	DT
cord-000238-om92cx5q	252	27	phenomenon	phenomenon	NN
cord-000238-om92cx5q	252	28	is	be	VBZ
cord-000238-om92cx5q	252	29	relevant	relevant	JJ
cord-000238-om92cx5q	252	30	in	in	IN
cord-000238-om92cx5q	252	31	this	this	DT
cord-000238-om92cx5q	252	32	case	case	NN
cord-000238-om92cx5q	252	33	of	of	IN
cord-000238-om92cx5q	252	34	influenza	influenza	NN
cord-000238-om92cx5q	252	35	strain	strain	NN
cord-000238-om92cx5q	252	36	H3N2	H3N2	NNP
cord-000238-om92cx5q	252	37	.	.	.
cord-000238-om92cx5q	253	1	Genetic	genetic	JJ
cord-000238-om92cx5q	253	2	robustness	robustness	NN
cord-000238-om92cx5q	253	3	in	in	IN
cord-000238-om92cx5q	253	4	the	the	DT
cord-000238-om92cx5q	253	5	hemagglutinin	hemagglutinin	NN
cord-000238-om92cx5q	254	1	͑HA͒	͑HA͒	,
cord-000238-om92cx5q	254	2	gene	gene	NN
cord-000238-om92cx5q	254	3	of	of	IN
cord-000238-om92cx5q	254	4	strain	strain	NN
cord-000238-om92cx5q	254	5	H3N2	H3N2	NNP
cord-000238-om92cx5q	254	6	allows	allow	VBZ
cord-000238-om92cx5q	254	7	the	the	DT
cord-000238-om92cx5q	254	8	virus	virus	NN
cord-000238-om92cx5q	254	9	to	to	TO
cord-000238-om92cx5q	254	10	drift	drift	VB
cord-000238-om92cx5q	254	11	through	through	IN
cord-000238-om92cx5q	254	12	neutral	neutral	JJ
cord-000238-om92cx5q	254	13	genotypic	genotypic	JJ
cord-000238-om92cx5q	254	14	space	space	NN
cord-000238-om92cx5q	254	15	without	without	IN
cord-000238-om92cx5q	254	16	a	a	DT
cord-000238-om92cx5q	254	17	change	change	NN
cord-000238-om92cx5q	254	18	in	in	IN
cord-000238-om92cx5q	254	19	phenotype	phenotype	NN
cord-000238-om92cx5q	254	20	until	until	IN
cord-000238-om92cx5q	254	21	it	-PRON-	PRP
cord-000238-om92cx5q	254	22	reaches	reach	VBZ
cord-000238-om92cx5q	254	23	a	a	DT
cord-000238-om92cx5q	254	24	rapid	rapid	JJ
cord-000238-om92cx5q	254	25	saltational	saltational	JJ
cord-000238-om92cx5q	254	26	phenotypic	phenotypic	NN
cord-000238-om92cx5q	254	27	shift	shift	NN
cord-000238-om92cx5q	254	28	that	that	WDT
cord-000238-om92cx5q	254	29	permits	permit	VBZ
cord-000238-om92cx5q	254	30	the	the	DT
cord-000238-om92cx5q	254	31	ability	ability	NN
cord-000238-om92cx5q	254	32	for	for	IN
cord-000238-om92cx5q	254	33	strains	strain	NNS
cord-000238-om92cx5q	254	34	derived	derive	VBN
cord-000238-om92cx5q	254	35	from	from	IN
cord-000238-om92cx5q	254	36	this	this	DT
cord-000238-om92cx5q	254	37	virus	virus	NN
cord-000238-om92cx5q	254	38	to	to	TO
cord-000238-om92cx5q	254	39	reemerge	reemerge	VB
cord-000238-om92cx5q	254	40	in	in	IN
cord-000238-om92cx5q	254	41	humans	human	NNS
cord-000238-om92cx5q	254	42	.	.	.
cord-000238-om92cx5q	255	1	This	this	DT
cord-000238-om92cx5q	255	2	model	model	NN
cord-000238-om92cx5q	255	3	is	be	VBZ
cord-000238-om92cx5q	255	4	compatible	compatible	JJ
cord-000238-om92cx5q	255	5	with	with	IN
cord-000238-om92cx5q	255	6	other	other	JJ
cord-000238-om92cx5q	255	7	robustness	robustness	NN
cord-000238-om92cx5q	255	8	-	-	HYPH
cord-000238-om92cx5q	255	9	evolvability	evolvability	NN
cord-000238-om92cx5q	255	10	links	link	NNS
cord-000238-om92cx5q	255	11	outlined	outline	VBN
cord-000238-om92cx5q	255	12	in	in	IN
cord-000238-om92cx5q	255	13	the	the	DT
cord-000238-om92cx5q	255	14	literature	literature	NN
cord-000238-om92cx5q	255	15	.	.	.
cord-000238-om92cx5q	256	1	57	57	CD
cord-000238-om92cx5q	256	2	,	,	,
cord-000238-om92cx5q	256	3	7	7	CD
cord-000238-om92cx5q	256	4	,	,	,
cord-000238-om92cx5q	256	5	8	8	CD
cord-000238-om92cx5q	256	6	Judging	judge	VBG
cord-000238-om92cx5q	256	7	from	from	IN
cord-000238-om92cx5q	256	8	phylogenetic	phylogenetic	JJ
cord-000238-om92cx5q	256	9	and	and	CC
cord-000238-om92cx5q	256	10	molecular	molecular	JJ
cord-000238-om92cx5q	256	11	evolution	evolution	NN
cord-000238-om92cx5q	256	12	analyses	analysis	NNS
cord-000238-om92cx5q	256	13	of	of	IN
cord-000238-om92cx5q	256	14	clinical	clinical	JJ
cord-000238-om92cx5q	256	15	isolates	isolate	NNS
cord-000238-om92cx5q	256	16	,	,	,
cord-000238-om92cx5q	256	17	it	-PRON-	PRP
cord-000238-om92cx5q	256	18	appears	appear	VBZ
cord-000238-om92cx5q	256	19	that	that	IN
cord-000238-om92cx5q	256	20	the	the	DT
cord-000238-om92cx5q	256	21	HA	HA	NNP
cord-000238-om92cx5q	256	22	gene	gene	NN
cord-000238-om92cx5q	256	23	of	of	IN
cord-000238-om92cx5q	256	24	influenza	influenza	NN
cord-000238-om92cx5q	256	25	A	a	DT
cord-000238-om92cx5q	256	26	virus	virus	NN
cord-000238-om92cx5q	256	27	appears	appear	VBZ
cord-000238-om92cx5q	256	28	to	to	TO
cord-000238-om92cx5q	256	29	be	be	VB
cord-000238-om92cx5q	256	30	under	under	IN
cord-000238-om92cx5q	256	31	strong	strong	JJ
cord-000238-om92cx5q	256	32	selection	selection	NN
cord-000238-om92cx5q	256	33	by	by	IN
cord-000238-om92cx5q	256	34	the	the	DT
cord-000238-om92cx5q	256	35	human	human	JJ
cord-000238-om92cx5q	256	36	immune	immune	NN
cord-000238-om92cx5q	256	37	system	system	NN
cord-000238-om92cx5q	256	38	,	,	,
cord-000238-om92cx5q	256	39	58	58	CD
cord-000238-om92cx5q	256	40	and	and	CC
cord-000238-om92cx5q	256	41	perhaps	perhaps	RB
cord-000238-om92cx5q	256	42	this	this	DT
cord-000238-om92cx5q	256	43	has	have	VBZ
cord-000238-om92cx5q	256	44	been	be	VBN
cord-000238-om92cx5q	256	45	true	true	JJ
cord-000238-om92cx5q	256	46	for	for	IN
cord-000238-om92cx5q	256	47	much	much	JJ
cord-000238-om92cx5q	256	48	of	of	IN
cord-000238-om92cx5q	256	49	the	the	DT
cord-000238-om92cx5q	256	50	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	256	51	history	history	NN
cord-000238-om92cx5q	256	52	of	of	IN
cord-000238-om92cx5q	256	53	flu	flu	NN
cord-000238-om92cx5q	256	54	disease	disease	NN
cord-000238-om92cx5q	256	55	in	in	IN
cord-000238-om92cx5q	256	56	humans	human	NNS
cord-000238-om92cx5q	256	57	.	.	.
cord-000238-om92cx5q	257	1	The	the	DT
cord-000238-om92cx5q	257	2	genetic	genetic	JJ
cord-000238-om92cx5q	257	3	robustness	robustness	NN
cord-000238-om92cx5q	257	4	of	of	IN
cord-000238-om92cx5q	257	5	influenza	influenza	NN
cord-000238-om92cx5q	257	6	viruses	virus	NNS
cord-000238-om92cx5q	257	7	and	and	CC
cord-000238-om92cx5q	257	8	the	the	DT
cord-000238-om92cx5q	257	9	accompanying	accompanying	JJ
cord-000238-om92cx5q	257	10	structure	structure	NN
cord-000238-om92cx5q	257	11	of	of	IN
cord-000238-om92cx5q	257	12	neutral	neutral	JJ
cord-000238-om92cx5q	257	13	genetic	genetic	JJ
cord-000238-om92cx5q	257	14	networks	network	NNS
cord-000238-om92cx5q	257	15	probably	probably	RB
cord-000238-om92cx5q	257	16	arose	arise	VBD
cord-000238-om92cx5q	257	17	to	to	TO
cord-000238-om92cx5q	257	18	foster	foster	VB
cord-000238-om92cx5q	257	19	the	the	DT
cord-000238-om92cx5q	257	20	epidemiological	epidemiological	JJ
cord-000238-om92cx5q	257	21	spread	spread	NN
cord-000238-om92cx5q	257	22	of	of	IN
cord-000238-om92cx5q	257	23	the	the	DT
cord-000238-om92cx5q	257	24	virus	virus	NN
cord-000238-om92cx5q	257	25	in	in	IN
cord-000238-om92cx5q	257	26	humans	human	NNS
cord-000238-om92cx5q	257	27	and/or	and/or	CC
cord-000238-om92cx5q	257	28	other	other	JJ
cord-000238-om92cx5q	257	29	animal	animal	NN
cord-000238-om92cx5q	257	30	hosts	host	NNS
cord-000238-om92cx5q	257	31	.	.	.
cord-000238-om92cx5q	258	1	The	the	DT
cord-000238-om92cx5q	258	2	size	size	NN
cord-000238-om92cx5q	258	3	of	of	IN
cord-000238-om92cx5q	258	4	these	these	DT
cord-000238-om92cx5q	258	5	neutral	neutral	JJ
cord-000238-om92cx5q	258	6	networks	network	NNS
cord-000238-om92cx5q	258	7	is	be	VBZ
cord-000238-om92cx5q	258	8	of	of	IN
cord-000238-om92cx5q	258	9	consequence	consequence	NN
cord-000238-om92cx5q	258	10	in	in	IN
cord-000238-om92cx5q	258	11	the	the	DT
cord-000238-om92cx5q	258	12	evolution	evolution	NN
cord-000238-om92cx5q	258	13	of	of	IN
cord-000238-om92cx5q	258	14	influenza	influenza	NN
cord-000238-om92cx5q	258	15	,	,	,
cord-000238-om92cx5q	258	16	as	as	IN
cord-000238-om92cx5q	258	17	suggested	suggest	VBN
cord-000238-om92cx5q	258	18	by	by	IN
cord-000238-om92cx5q	258	19	modern	modern	JJ
cord-000238-om92cx5q	258	20	robustness	robustness	NN
cord-000238-om92cx5q	258	21	theory	theory	NN
cord-000238-om92cx5q	258	22	.	.	.
cord-000238-om92cx5q	259	1	8	8	CD
cord-000238-om92cx5q	260	1	A	a	DT
cord-000238-om92cx5q	260	2	HA	HA	NNP
cord-000238-om92cx5q	260	3	gene	gene	NN
cord-000238-om92cx5q	260	4	with	with	IN
cord-000238-om92cx5q	260	5	relatively	relatively	RB
cord-000238-om92cx5q	260	6	low	low	JJ
cord-000238-om92cx5q	260	7	robustness	robustness	NN
cord-000238-om92cx5q	260	8	would	would	MD
cord-000238-om92cx5q	260	9	feature	feature	VB
cord-000238-om92cx5q	260	10	a	a	DT
cord-000238-om92cx5q	260	11	small	small	JJ
cord-000238-om92cx5q	260	12	neutral	neutral	JJ
cord-000238-om92cx5q	260	13	network	network	NN
cord-000238-om92cx5q	260	14	;	;	:
cord-000238-om92cx5q	260	15	this	this	DT
cord-000238-om92cx5q	260	16	characteristic	characteristic	NN
cord-000238-om92cx5q	260	17	might	may	MD
cord-000238-om92cx5q	260	18	cause	cause	VB
cord-000238-om92cx5q	260	19	the	the	DT
cord-000238-om92cx5q	260	20	virus	virus	NN
cord-000238-om92cx5q	260	21	to	to	TO
cord-000238-om92cx5q	260	22	molecularly	molecularly	RB
cord-000238-om92cx5q	260	23	evolve	evolve	VB
cord-000238-om92cx5q	260	24	rather	rather	RB
cord-000238-om92cx5q	260	25	quickly	quickly	RB
cord-000238-om92cx5q	260	26	,	,	,
cord-000238-om92cx5q	260	27	perhaps	perhaps	RB
cord-000238-om92cx5q	260	28	outpacing	outpace	VBG
cord-000238-om92cx5q	260	29	the	the	DT
cord-000238-om92cx5q	260	30	availability	availability	NN
cord-000238-om92cx5q	260	31	of	of	IN
cord-000238-om92cx5q	260	32	susceptible	susceptible	JJ
cord-000238-om92cx5q	260	33	individuals	individual	NNS
cord-000238-om92cx5q	260	34	in	in	IN
cord-000238-om92cx5q	260	35	a	a	DT
cord-000238-om92cx5q	260	36	host	host	NN
cord-000238-om92cx5q	260	37	population	population	NN
cord-000238-om92cx5q	260	38	,	,	,
cord-000238-om92cx5q	260	39	slowing	slow	VBG
cord-000238-om92cx5q	260	40	or	or	CC
cord-000238-om92cx5q	260	41	halting	halting	JJ
cord-000238-om92cx5q	260	42	spread	spread	NN
cord-000238-om92cx5q	260	43	of	of	IN
cord-000238-om92cx5q	260	44	the	the	DT
cord-000238-om92cx5q	260	45	virus	virus	NN
cord-000238-om92cx5q	260	46	.	.	.
cord-000238-om92cx5q	261	1	But	but	CC
cord-000238-om92cx5q	261	2	a	a	DT
cord-000238-om92cx5q	261	3	relatively	relatively	RB
cord-000238-om92cx5q	261	4	larger	large	JJR
cord-000238-om92cx5q	261	5	neutral	neutral	JJ
cord-000238-om92cx5q	261	6	network	network	NN
cord-000238-om92cx5q	261	7	would	would	MD
cord-000238-om92cx5q	261	8	afford	afford	VB
cord-000238-om92cx5q	261	9	greater	great	JJR
cord-000238-om92cx5q	261	10	robustness	robustness	NN
cord-000238-om92cx5q	261	11	of	of	IN
cord-000238-om92cx5q	261	12	HA	HA	NNP
cord-000238-om92cx5q	261	13	genes	gene	NNS
cord-000238-om92cx5q	261	14	in	in	IN
cord-000238-om92cx5q	261	15	influenza	influenza	NN
cord-000238-om92cx5q	261	16	,	,	,
cord-000238-om92cx5q	261	17	affording	afford	VBG
cord-000238-om92cx5q	261	18	long	long	JJ
cord-000238-om92cx5q	261	19	-	-	HYPH
cord-000238-om92cx5q	261	20	term	term	NN
cord-000238-om92cx5q	261	21	persistence	persistence	NN
cord-000238-om92cx5q	261	22	of	of	IN
cord-000238-om92cx5q	261	23	the	the	DT
cord-000238-om92cx5q	261	24	virus	virus	NN
cord-000238-om92cx5q	261	25	as	as	IN
cord-000238-om92cx5q	261	26	it	-PRON-	PRP
cord-000238-om92cx5q	261	27	drifts	drift	VBZ
cord-000238-om92cx5q	261	28	neutrally	neutrally	RB
cord-000238-om92cx5q	261	29	through	through	IN
cord-000238-om92cx5q	261	30	sequence	sequence	NN
cord-000238-om92cx5q	261	31	space	space	NN
cord-000238-om92cx5q	261	32	before	before	IN
cord-000238-om92cx5q	261	33	fortuitously	fortuitously	RB
cord-000238-om92cx5q	261	34	achieving	achieve	VBG
cord-000238-om92cx5q	261	35	a	a	DT
cord-000238-om92cx5q	261	36	genotype	genotype	NN
cord-000238-om92cx5q	261	37	with	with	IN
cord-000238-om92cx5q	261	38	a	a	DT
cord-000238-om92cx5q	261	39	beneficial	beneficial	JJ
cord-000238-om92cx5q	261	40	novel	novel	NN
cord-000238-om92cx5q	261	41	surface	surface	NN
cord-000238-om92cx5q	261	42	antigen	antigen	NN
cord-000238-om92cx5q	261	43	that	that	WDT
cord-000238-om92cx5q	261	44	promotes	promote	VBZ
cord-000238-om92cx5q	261	45	reemergence	reemergence	NN
cord-000238-om92cx5q	261	46	.	.	.
cord-000238-om92cx5q	262	1	Genetic	genetic	JJ
cord-000238-om92cx5q	262	2	robustness	robustness	NN
cord-000238-om92cx5q	262	3	in	in	IN
cord-000238-om92cx5q	262	4	the	the	DT
cord-000238-om92cx5q	262	5	genetic	genetic	JJ
cord-000238-om92cx5q	262	6	networks	network	NNS
cord-000238-om92cx5q	262	7	of	of	IN
cord-000238-om92cx5q	262	8	influenza	influenza	NN
cord-000238-om92cx5q	262	9	A	a	DT
cord-000238-om92cx5q	262	10	virus	virus	NN
cord-000238-om92cx5q	262	11	might	may	MD
cord-000238-om92cx5q	262	12	have	have	VB
cord-000238-om92cx5q	262	13	an	an	DT
cord-000238-om92cx5q	262	14	environmental	environmental	JJ
cord-000238-om92cx5q	262	15	robustness	robustness	NN
cord-000238-om92cx5q	262	16	correlate	correlate	VBP
cord-000238-om92cx5q	262	17	.	.	.
cord-000238-om92cx5q	263	1	Influenza	Influenza	NNP
cord-000238-om92cx5q	263	2	A	a	DT
cord-000238-om92cx5q	263	3	virus	virus	NN
cord-000238-om92cx5q	263	4	is	be	VBZ
cord-000238-om92cx5q	263	5	notorious	notorious	JJ
cord-000238-om92cx5q	263	6	for	for	IN
cord-000238-om92cx5q	263	7	its	-PRON-	PRP$
cord-000238-om92cx5q	263	8	characteristically	characteristically	RB
cord-000238-om92cx5q	263	9	broad	broad	JJ
cord-000238-om92cx5q	263	10	host	host	NN
cord-000238-om92cx5q	263	11	range	range	NN
cord-000238-om92cx5q	263	12	,	,	,
cord-000238-om92cx5q	263	13	including	include	VBG
cord-000238-om92cx5q	263	14	various	various	JJ
cord-000238-om92cx5q	263	15	bird	bird	NN
cord-000238-om92cx5q	263	16	species	specie	NNS
cord-000238-om92cx5q	263	17	and	and	CC
cord-000238-om92cx5q	263	18	mammals	mammal	NNS
cord-000238-om92cx5q	263	19	such	such	JJ
cord-000238-om92cx5q	263	20	as	as	IN
cord-000238-om92cx5q	263	21	domesticated	domesticate	VBN
cord-000238-om92cx5q	263	22	pigs	pig	NNS
cord-000238-om92cx5q	263	23	whose	whose	WP$
cord-000238-om92cx5q	263	24	proximity	proximity	NN
cord-000238-om92cx5q	263	25	to	to	IN
cord-000238-om92cx5q	263	26	humans	human	NNS
cord-000238-om92cx5q	263	27	may	may	MD
cord-000238-om92cx5q	263	28	spur	spur	VB
cord-000238-om92cx5q	263	29	pandemics	pandemic	NNS
cord-000238-om92cx5q	263	30	.	.	.
cord-000238-om92cx5q	264	1	[	[	-LRB-
cord-000238-om92cx5q	264	2	59	59	CD
cord-000238-om92cx5q	264	3	]	]	-RRB-
cord-000238-om92cx5q	264	4	[	[	-LRB-
cord-000238-om92cx5q	264	5	60	60	CD
cord-000238-om92cx5q	264	6	]	]	-RRB-
cord-000238-om92cx5q	265	1	[	[	-LRB-
cord-000238-om92cx5q	265	2	61	61	CD
cord-000238-om92cx5q	265	3	]	]	-RRB-
cord-000238-om92cx5q	266	1	As	as	IN
cord-000238-om92cx5q	266	2	noted	note	VBN
cord-000238-om92cx5q	266	3	earlier	early	RBR
cord-000238-om92cx5q	266	4	,	,	,
cord-000238-om92cx5q	266	5	relatively	relatively	RB
cord-000238-om92cx5q	266	6	broad	broad	JJ
cord-000238-om92cx5q	266	7	host	host	NN
cord-000238-om92cx5q	266	8	range	range	NN
cord-000238-om92cx5q	266	9	of	of	IN
cord-000238-om92cx5q	266	10	a	a	DT
cord-000238-om92cx5q	266	11	pathogen	pathogen	NN
cord-000238-om92cx5q	266	12	may	may	MD
cord-000238-om92cx5q	266	13	be	be	VB
cord-000238-om92cx5q	266	14	defined	define	VBN
cord-000238-om92cx5q	266	15	as	as	IN
cord-000238-om92cx5q	266	16	environmental	environmental	JJ
cord-000238-om92cx5q	266	17	robustness	robustness	NN
cord-000238-om92cx5q	266	18	.	.	.
cord-000238-om92cx5q	267	1	The	the	DT
cord-000238-om92cx5q	267	2	ability	ability	NN
cord-000238-om92cx5q	267	3	for	for	IN
cord-000238-om92cx5q	267	4	influenza	influenza	NN
cord-000238-om92cx5q	267	5	A	a	DT
cord-000238-om92cx5q	267	6	viruses	virus	NNS
cord-000238-om92cx5q	267	7	to	to	TO
cord-000238-om92cx5q	267	8	traverse	traverse	VB
cord-000238-om92cx5q	267	9	the	the	DT
cord-000238-om92cx5q	267	10	aforementioned	aforementioned	JJ
cord-000238-om92cx5q	267	11	neutral	neutral	JJ
cord-000238-om92cx5q	267	12	network	network	NN
cord-000238-om92cx5q	267	13	of	of	IN
cord-000238-om92cx5q	267	14	genetic	genetic	JJ
cord-000238-om92cx5q	267	15	robustness	robustness	NN
cord-000238-om92cx5q	267	16	may	may	MD
cord-000238-om92cx5q	267	17	have	have	VB
cord-000238-om92cx5q	267	18	an	an	DT
cord-000238-om92cx5q	267	19	important	important	JJ
cord-000238-om92cx5q	267	20	environmental	environmental	JJ
cord-000238-om92cx5q	267	21	robustness	robustness	NN
cord-000238-om92cx5q	267	22	component	component	NN
cord-000238-om92cx5q	267	23	.	.	.
cord-000238-om92cx5q	268	1	The	the	DT
cord-000238-om92cx5q	268	2	virus	virus	NN
cord-000238-om92cx5q	268	3	may	may	MD
cord-000238-om92cx5q	268	4	be	be	VB
cord-000238-om92cx5q	268	5	able	able	JJ
cord-000238-om92cx5q	268	6	to	to	TO
cord-000238-om92cx5q	268	7	easily	easily	RB
cord-000238-om92cx5q	268	8	create	create	VB
cord-000238-om92cx5q	268	9	a	a	DT
cord-000238-om92cx5q	268	10	robust	robust	JJ
cord-000238-om92cx5q	268	11	neutral	neutral	JJ
cord-000238-om92cx5q	268	12	network	network	NN
cord-000238-om92cx5q	268	13	of	of	IN
cord-000238-om92cx5q	268	14	genotypes	genotype	NNS
cord-000238-om92cx5q	268	15	associated	associate	VBN
cord-000238-om92cx5q	268	16	with	with	IN
cord-000238-om92cx5q	268	17	attachment	attachment	NN
cord-000238-om92cx5q	268	18	/	/	SYM
cord-000238-om92cx5q	268	19	entry	entry	NN
cord-000238-om92cx5q	268	20	of	of	IN
cord-000238-om92cx5q	268	21	various	various	JJ
cord-000238-om92cx5q	268	22	host	host	NN
cord-000238-om92cx5q	268	23	cells	cell	NNS
cord-000238-om92cx5q	268	24	due	due	JJ
cord-000238-om92cx5q	268	25	to	to	IN
cord-000238-om92cx5q	268	26	intrinsic	intrinsic	JJ
cord-000238-om92cx5q	268	27	environmental	environmental	JJ
cord-000238-om92cx5q	268	28	robustness	robustness	NN
cord-000238-om92cx5q	268	29	that	that	WDT
cord-000238-om92cx5q	268	30	evolved	evolve	VBD
cord-000238-om92cx5q	268	31	via	via	IN
cord-000238-om92cx5q	268	32	selection	selection	NN
cord-000238-om92cx5q	268	33	to	to	TO
cord-000238-om92cx5q	268	34	infect	infect	VB
cord-000238-om92cx5q	268	35	a	a	DT
cord-000238-om92cx5q	268	36	variety	variety	NN
cord-000238-om92cx5q	268	37	of	of	IN
cord-000238-om92cx5q	268	38	host	host	NN
cord-000238-om92cx5q	268	39	environments	environment	NNS
cord-000238-om92cx5q	268	40	.	.	.
cord-000238-om92cx5q	269	1	In	in	IN
cord-000238-om92cx5q	269	2	influenza	influenza	NN
cord-000238-om92cx5q	269	3	A	a	DT
cord-000238-om92cx5q	269	4	virus	virus	NN
cord-000238-om92cx5q	269	5	,	,	,
cord-000238-om92cx5q	269	6	whether	whether	IN
cord-000238-om92cx5q	269	7	environmental	environmental	JJ
cord-000238-om92cx5q	269	8	robustness	robustness	NN
cord-000238-om92cx5q	269	9	preceded	precede	VBD
cord-000238-om92cx5q	269	10	genetic	genetic	JJ
cord-000238-om92cx5q	269	11	robustness	robustness	NN
cord-000238-om92cx5q	269	12	,	,	,
cord-000238-om92cx5q	269	13	or	or	CC
cord-000238-om92cx5q	269	14	vice	vice	NN
cord-000238-om92cx5q	269	15	versa	versa	RB
cord-000238-om92cx5q	269	16	,	,	,
cord-000238-om92cx5q	269	17	is	be	VBZ
cord-000238-om92cx5q	269	18	difficult	difficult	JJ
cord-000238-om92cx5q	269	19	to	to	TO
cord-000238-om92cx5q	269	20	know	know	VB
cord-000238-om92cx5q	269	21	.	.	.
cord-000238-om92cx5q	270	1	But	but	CC
cord-000238-om92cx5q	270	2	environmental	environmental	JJ
cord-000238-om92cx5q	270	3	robustness	robustness	NN
cord-000238-om92cx5q	270	4	of	of	IN
cord-000238-om92cx5q	270	5	viruses	virus	NNS
cord-000238-om92cx5q	270	6	such	such	JJ
cord-000238-om92cx5q	270	7	as	as	IN
cord-000238-om92cx5q	270	8	influenza	influenza	NN
cord-000238-om92cx5q	270	9	A	a	DT
cord-000238-om92cx5q	270	10	virus	virus	NN
cord-000238-om92cx5q	270	11	undoubtedly	undoubtedly	RB
cord-000238-om92cx5q	270	12	fosters	foster	VBZ
cord-000238-om92cx5q	270	13	the	the	DT
cord-000238-om92cx5q	270	14	ability	ability	NN
cord-000238-om92cx5q	270	15	to	to	TO
cord-000238-om92cx5q	270	16	reside	reside	VB
cord-000238-om92cx5q	270	17	in	in	IN
cord-000238-om92cx5q	270	18	various	various	JJ
cord-000238-om92cx5q	270	19	host	host	NN
cord-000238-om92cx5q	270	20	species	specie	NNS
cord-000238-om92cx5q	270	21	that	that	WDT
cord-000238-om92cx5q	270	22	may	may	MD
cord-000238-om92cx5q	270	23	serve	serve	VB
cord-000238-om92cx5q	270	24	as	as	IN
cord-000238-om92cx5q	270	25	reservoirs	reservoir	NNS
cord-000238-om92cx5q	270	26	that	that	WDT
cord-000238-om92cx5q	270	27	allow	allow	VBP
cord-000238-om92cx5q	270	28	occasional	occasional	JJ
cord-000238-om92cx5q	270	29	spillover	spillover	NN
cord-000238-om92cx5q	270	30	into	into	IN
cord-000238-om92cx5q	270	31	a	a	DT
cord-000238-om92cx5q	270	32	species	species	NN
cord-000238-om92cx5q	270	33	of	of	IN
cord-000238-om92cx5q	270	34	interest	interest	NN
cord-000238-om92cx5q	270	35	such	such	JJ
cord-000238-om92cx5q	270	36	as	as	IN
cord-000238-om92cx5q	270	37	humans	human	NNS
cord-000238-om92cx5q	270	38	.	.	.
cord-000238-om92cx5q	271	1	52	52	CD
cord-000238-om92cx5q	271	2	Robustness	robustness	NN
cord-000238-om92cx5q	271	3	may	may	MD
cord-000238-om92cx5q	271	4	also	also	RB
cord-000238-om92cx5q	271	5	be	be	VB
cord-000238-om92cx5q	271	6	relevant	relevant	JJ
cord-000238-om92cx5q	271	7	in	in	IN
cord-000238-om92cx5q	271	8	explaining	explain	VBG
cord-000238-om92cx5q	271	9	aspects	aspect	NNS
cord-000238-om92cx5q	271	10	of	of	IN
cord-000238-om92cx5q	271	11	the	the	DT
cord-000238-om92cx5q	271	12	current	current	JJ
cord-000238-om92cx5q	271	13	AIDS	AIDS	NNP
cord-000238-om92cx5q	271	14	pandemic	pandemic	NN
cord-000238-om92cx5q	271	15	.	.	.
cord-000238-om92cx5q	272	1	A	a	DT
cord-000238-om92cx5q	272	2	global	global	JJ
cord-000238-om92cx5q	272	3	increase	increase	NN
cord-000238-om92cx5q	272	4	in	in	IN
cord-000238-om92cx5q	272	5	robustness	robustness	NN
cord-000238-om92cx5q	272	6	has	have	VBZ
cord-000238-om92cx5q	272	7	been	be	VBN
cord-000238-om92cx5q	272	8	invoked	invoke	VBN
cord-000238-om92cx5q	272	9	to	to	TO
cord-000238-om92cx5q	272	10	explain	explain	VB
cord-000238-om92cx5q	272	11	an	an	DT
cord-000238-om92cx5q	272	12	apparent	apparent	JJ
cord-000238-om92cx5q	272	13	global	global	JJ
cord-000238-om92cx5q	272	14	decline	decline	NN
cord-000238-om92cx5q	272	15	in	in	IN
cord-000238-om92cx5q	272	16	the	the	DT
cord-000238-om92cx5q	272	17	virulence	virulence	NN
cord-000238-om92cx5q	272	18	of	of	IN
cord-000238-om92cx5q	272	19	HIV-1	HIV-1	NNP
cord-000238-om92cx5q	272	20	strains	strain	NNS
cord-000238-om92cx5q	272	21	.	.	.
cord-000238-om92cx5q	273	1	38	38	CD
cord-000238-om92cx5q	274	1	Although	although	IN
cord-000238-om92cx5q	274	2	it	-PRON-	PRP
cord-000238-om92cx5q	274	3	was	be	VBD
cord-000238-om92cx5q	274	4	not	not	RB
cord-000238-om92cx5q	274	5	discussed	discuss	VBN
cord-000238-om92cx5q	274	6	extensively	extensively	RB
cord-000238-om92cx5q	274	7	,	,	,
cord-000238-om92cx5q	274	8	the	the	DT
cord-000238-om92cx5q	274	9	robustness	robustness	NN
cord-000238-om92cx5q	274	10	concept	concept	NN
cord-000238-om92cx5q	274	11	in	in	IN
cord-000238-om92cx5q	274	12	this	this	DT
cord-000238-om92cx5q	274	13	example	example	NN
cord-000238-om92cx5q	274	14	seems	seem	VBZ
cord-000238-om92cx5q	274	15	to	to	TO
cord-000238-om92cx5q	274	16	be	be	VB
cord-000238-om92cx5q	274	17	environmentally	environmentally	RB
cord-000238-om92cx5q	274	18	,	,	,
cord-000238-om92cx5q	274	19	not	not	RB
cord-000238-om92cx5q	274	20	mutationally	mutationally	RB
cord-000238-om92cx5q	274	21	,	,	,
cord-000238-om92cx5q	274	22	determined	determine	VBN
cord-000238-om92cx5q	274	23	.	.	.
cord-000238-om92cx5q	275	1	The	the	DT
cord-000238-om92cx5q	275	2	argument	argument	NN
cord-000238-om92cx5q	275	3	is	be	VBZ
cord-000238-om92cx5q	275	4	that	that	IN
cord-000238-om92cx5q	275	5	a	a	DT
cord-000238-om92cx5q	275	6	perceived	perceive	VBN
cord-000238-om92cx5q	275	7	decline	decline	NN
cord-000238-om92cx5q	275	8	in	in	IN
cord-000238-om92cx5q	275	9	HIV-1	HIV-1	NNP
cord-000238-om92cx5q	275	10	virulence	virulence	NN
cord-000238-om92cx5q	275	11	might	may	MD
cord-000238-om92cx5q	275	12	be	be	VB
cord-000238-om92cx5q	275	13	due	due	JJ
cord-000238-om92cx5q	275	14	to	to	IN
cord-000238-om92cx5q	275	15	generally	generally	RB
cord-000238-om92cx5q	275	16	evolved	evolve	VBN
cord-000238-om92cx5q	275	17	increase	increase	VB
cord-000238-om92cx5q	275	18	in	in	IN
cord-000238-om92cx5q	275	19	environmental	environmental	JJ
cord-000238-om92cx5q	275	20	robustness	robustness	NN
cord-000238-om92cx5q	275	21	of	of	IN
cord-000238-om92cx5q	275	22	the	the	DT
cord-000238-om92cx5q	275	23	virus	virus	NN
cord-000238-om92cx5q	275	24	,	,	,
cord-000238-om92cx5q	275	25	owing	owe	VBG
cord-000238-om92cx5q	275	26	to	to	IN
cord-000238-om92cx5q	275	27	its	-PRON-	PRP$
cord-000238-om92cx5q	275	28	worldwide	worldwide	JJ
cord-000238-om92cx5q	275	29	spread	spread	NN
cord-000238-om92cx5q	275	30	.	.	.
cord-000238-om92cx5q	276	1	The	the	DT
cord-000238-om92cx5q	276	2	virus	virus	NN
cord-000238-om92cx5q	276	3	has	have	VBZ
cord-000238-om92cx5q	276	4	thus	thus	RB
cord-000238-om92cx5q	276	5	encountered	encounter	VBN
cord-000238-om92cx5q	276	6	variable	variable	JJ
cord-000238-om92cx5q	276	7	subpopulations	subpopulation	NNS
cord-000238-om92cx5q	276	8	of	of	IN
cord-000238-om92cx5q	276	9	humans	human	NNS
cord-000238-om92cx5q	276	10	and	and	CC
cord-000238-om92cx5q	276	11	has	have	VBZ
cord-000238-om92cx5q	276	12	undergone	undergo	VBN
cord-000238-om92cx5q	276	13	selection	selection	NN
cord-000238-om92cx5q	276	14	for	for	IN
cord-000238-om92cx5q	276	15	environmental	environmental	JJ
cord-000238-om92cx5q	276	16	robustness	robustness	NN
cord-000238-om92cx5q	276	17	,	,	,
cord-000238-om92cx5q	276	18	which	which	WDT
cord-000238-om92cx5q	276	19	coincides	coincide	VBZ
cord-000238-om92cx5q	276	20	with	with	IN
cord-000238-om92cx5q	276	21	improved	improved	JJ
cord-000238-om92cx5q	276	22	performance	performance	NN
cord-000238-om92cx5q	276	23	across	across	IN
cord-000238-om92cx5q	276	24	environments	environment	NNS
cord-000238-om92cx5q	276	25	at	at	IN
cord-000238-om92cx5q	276	26	the	the	DT
cord-000238-om92cx5q	276	27	expense	expense	NN
cord-000238-om92cx5q	276	28	of	of	IN
cord-000238-om92cx5q	276	29	reduced	reduce	VBN
cord-000238-om92cx5q	276	30	reproduction	reproduction	NN
cord-000238-om92cx5q	277	1	͑i.e	͑i.e	NFP
cord-000238-om92cx5q	277	2	.	.	.
cord-000238-om92cx5q	278	1	,	,	,
cord-000238-om92cx5q	278	2	virulence͒	virulence͒	VBG
cord-000238-om92cx5q	278	3	on	on	IN
cord-000238-om92cx5q	278	4	average	average	JJ
cord-000238-om92cx5q	278	5	.	.	.
cord-000238-om92cx5q	279	1	This	this	DT
cord-000238-om92cx5q	279	2	explanation	explanation	NN
cord-000238-om92cx5q	279	3	assumes	assume	VBZ
cord-000238-om92cx5q	279	4	that	that	IN
cord-000238-om92cx5q	279	5	the	the	DT
cord-000238-om92cx5q	279	6	stated	state	VBN
cord-000238-om92cx5q	279	7	tradeoff	tradeoff	NN
cord-000238-om92cx5q	279	8	in	in	IN
cord-000238-om92cx5q	279	9	viral	viral	JJ
cord-000238-om92cx5q	279	10	traits	trait	NNS
cord-000238-om92cx5q	279	11	is	be	VBZ
cord-000238-om92cx5q	279	12	a	a	DT
cord-000238-om92cx5q	279	13	generalized	generalized	JJ
cord-000238-om92cx5q	279	14	phenomenon	phenomenon	NN
cord-000238-om92cx5q	279	15	,	,	,
cord-000238-om92cx5q	279	16	and	and	CC
cord-000238-om92cx5q	279	17	that	that	IN
cord-000238-om92cx5q	279	18	results	result	NNS
cord-000238-om92cx5q	279	19	for	for	IN
cord-000238-om92cx5q	279	20	increased	increase	VBN
cord-000238-om92cx5q	279	21	genetic	genetic	JJ
cord-000238-om92cx5q	279	22	robustness	robustness	NN
cord-000238-om92cx5q	279	23	at	at	IN
cord-000238-om92cx5q	279	24	the	the	DT
cord-000238-om92cx5q	279	25	expense	expense	NN
cord-000238-om92cx5q	279	26	of	of	IN
cord-000238-om92cx5q	279	27	reduced	reduced	JJ
cord-000238-om92cx5q	279	28	reproduction	reproduction	NN
cord-000238-om92cx5q	279	29	9,13	9,13	CD
cord-000238-om92cx5q	279	30	apply	apply	VBP
cord-000238-om92cx5q	279	31	in	in	IN
cord-000238-om92cx5q	279	32	the	the	DT
cord-000238-om92cx5q	279	33	case	case	NN
cord-000238-om92cx5q	279	34	of	of	IN
cord-000238-om92cx5q	279	35	environmental	environmental	JJ
cord-000238-om92cx5q	279	36	robustness	robustness	NN
cord-000238-om92cx5q	279	37	as	as	RB
cord-000238-om92cx5q	279	38	well	well	RB
cord-000238-om92cx5q	279	39	.	.	.
cord-000238-om92cx5q	280	1	Regardless	regardless	RB
cord-000238-om92cx5q	280	2	of	of	IN
cord-000238-om92cx5q	280	3	the	the	DT
cord-000238-om92cx5q	280	4	disease	disease	NN
cord-000238-om92cx5q	280	5	system	system	NN
cord-000238-om92cx5q	280	6	,	,	,
cord-000238-om92cx5q	280	7	pharmacology	pharmacology	NN
cord-000238-om92cx5q	280	8	involves	involve	VBZ
cord-000238-om92cx5q	280	9	the	the	DT
cord-000238-om92cx5q	280	10	use	use	NN
cord-000238-om92cx5q	280	11	of	of	IN
cord-000238-om92cx5q	280	12	small	small	JJ
cord-000238-om92cx5q	280	13	molecule	molecule	NN
cord-000238-om92cx5q	280	14	inhibitors	inhibitor	NNS
cord-000238-om92cx5q	280	15	of	of	IN
cord-000238-om92cx5q	280	16	biomolecular	biomolecular	JJ
cord-000238-om92cx5q	280	17	interactions	interaction	NNS
cord-000238-om92cx5q	280	18	,	,	,
cord-000238-om92cx5q	280	19	and	and	CC
cord-000238-om92cx5q	280	20	we	-PRON-	PRP
cord-000238-om92cx5q	280	21	believe	believe	VBP
cord-000238-om92cx5q	280	22	that	that	IN
cord-000238-om92cx5q	280	23	robustness	robustness	NN
cord-000238-om92cx5q	280	24	may	may	MD
cord-000238-om92cx5q	280	25	be	be	VB
cord-000238-om92cx5q	280	26	a	a	DT
cord-000238-om92cx5q	280	27	highly	highly	RB
cord-000238-om92cx5q	280	28	relevant	relevant	JJ
cord-000238-om92cx5q	280	29	concept	concept	NN
cord-000238-om92cx5q	280	30	in	in	IN
cord-000238-om92cx5q	280	31	the	the	DT
cord-000238-om92cx5q	280	32	identification	identification	NN
cord-000238-om92cx5q	280	33	of	of	IN
cord-000238-om92cx5q	280	34	potential	potential	JJ
cord-000238-om92cx5q	280	35	drug	drug	NN
cord-000238-om92cx5q	280	36	targets	target	NNS
cord-000238-om92cx5q	280	37	.	.	.
cord-000238-om92cx5q	281	1	This	this	DT
cord-000238-om92cx5q	281	2	logic	logic	NN
cord-000238-om92cx5q	281	3	begins	begin	VBZ
cord-000238-om92cx5q	281	4	with	with	IN
cord-000238-om92cx5q	281	5	identifying	identify	VBG
cord-000238-om92cx5q	281	6	in	in	IN
cord-000238-om92cx5q	281	7	pathogen	pathogen	NN
cord-000238-om92cx5q	281	8	systems	system	NNS
cord-000238-om92cx5q	281	9	the	the	DT
cord-000238-om92cx5q	281	10	modules	module	NNS
cord-000238-om92cx5q	281	11	that	that	WDT
cord-000238-om92cx5q	281	12	may	may	MD
cord-000238-om92cx5q	281	13	serve	serve	VB
cord-000238-om92cx5q	281	14	as	as	IN
cord-000238-om92cx5q	281	15	good	good	JJ
cord-000238-om92cx5q	281	16	targets	target	NNS
cord-000238-om92cx5q	281	17	versus	versus	IN
cord-000238-om92cx5q	281	18	those	those	DT
cord-000238-om92cx5q	281	19	that	that	WDT
cord-000238-om92cx5q	281	20	would	would	MD
cord-000238-om92cx5q	281	21	be	be	VB
cord-000238-om92cx5q	281	22	poor	poor	JJ
cord-000238-om92cx5q	281	23	targets	target	NNS
cord-000238-om92cx5q	281	24	for	for	IN
cord-000238-om92cx5q	281	25	pharmacological	pharmacological	JJ
cord-000238-om92cx5q	281	26	intervention	intervention	NN
cord-000238-om92cx5q	281	27	.	.	.
cord-000238-om92cx5q	282	1	Presumably	presumably	RB
cord-000238-om92cx5q	282	2	,	,	,
cord-000238-om92cx5q	282	3	poor	poor	JJ
cord-000238-om92cx5q	282	4	targets	target	NNS
cord-000238-om92cx5q	282	5	would	would	MD
cord-000238-om92cx5q	282	6	be	be	VB
cord-000238-om92cx5q	282	7	modules	module	NNS
cord-000238-om92cx5q	282	8	that	that	WDT
cord-000238-om92cx5q	282	9	are	be	VBP
cord-000238-om92cx5q	282	10	robust	robust	JJ
cord-000238-om92cx5q	282	11	to	to	IN
cord-000238-om92cx5q	282	12	perturbations	perturbation	NNS
cord-000238-om92cx5q	282	13	,	,	,
cord-000238-om92cx5q	282	14	pharmacological	pharmacological	JJ
cord-000238-om92cx5q	282	15	agents	agent	NNS
cord-000238-om92cx5q	282	16	included	include	VBD
cord-000238-om92cx5q	282	17	.	.	.
cord-000238-om92cx5q	283	1	When	when	WRB
cord-000238-om92cx5q	283	2	designing	design	VBG
cord-000238-om92cx5q	283	3	drugs	drug	NNS
cord-000238-om92cx5q	283	4	to	to	TO
cord-000238-om92cx5q	283	5	treat	treat	VB
cord-000238-om92cx5q	283	6	infections	infection	NNS
cord-000238-om92cx5q	283	7	,	,	,
cord-000238-om92cx5q	283	8	the	the	DT
cord-000238-om92cx5q	283	9	invasion	invasion	NN
cord-000238-om92cx5q	283	10	step	step	NN
cord-000238-om92cx5q	283	11	is	be	VBZ
cord-000238-om92cx5q	283	12	where	where	WRB
cord-000238-om92cx5q	283	13	the	the	DT
cord-000238-om92cx5q	283	14	pathogens	pathogen	NNS
cord-000238-om92cx5q	283	15	might	may	MD
cord-000238-om92cx5q	283	16	be	be	VB
cord-000238-om92cx5q	283	17	most	most	RBS
cord-000238-om92cx5q	283	18	vulnerable	vulnerable	JJ
cord-000238-om92cx5q	283	19	to	to	IN
cord-000238-om92cx5q	283	20	pharmacological	pharmacological	JJ
cord-000238-om92cx5q	283	21	intervention	intervention	NN
cord-000238-om92cx5q	283	22	.	.	.
cord-000238-om92cx5q	284	1	This	this	DT
cord-000238-om92cx5q	284	2	idea	idea	NN
cord-000238-om92cx5q	284	3	is	be	VBZ
cord-000238-om92cx5q	284	4	supported	support	VBN
cord-000238-om92cx5q	284	5	by	by	IN
cord-000238-om92cx5q	284	6	studies	study	NNS
cord-000238-om92cx5q	284	7	in	in	IN
cord-000238-om92cx5q	284	8	which	which	WDT
cord-000238-om92cx5q	284	9	parasite	parasite	NN
cord-000238-om92cx5q	284	10	exposure	exposure	NN
cord-000238-om92cx5q	284	11	to	to	IN
cord-000238-om92cx5q	284	12	chemical	chemical	NN
cord-000238-om92cx5q	284	13	compounds	compound	NNS
cord-000238-om92cx5q	284	14	neutralizes	neutralize	VBZ
cord-000238-om92cx5q	284	15	binding	bind	VBG
cord-000238-om92cx5q	284	16	to	to	IN
cord-000238-om92cx5q	284	17	host	host	NN
cord-000238-om92cx5q	284	18	receptors	receptor	NNS
cord-000238-om92cx5q	284	19	,	,	,
cord-000238-om92cx5q	284	20	fortifying	fortify	VBG
cord-000238-om92cx5q	284	21	the	the	DT
cord-000238-om92cx5q	284	22	importance	importance	NN
cord-000238-om92cx5q	284	23	of	of	IN
cord-000238-om92cx5q	284	24	invasion	invasion	NN
cord-000238-om92cx5q	284	25	to	to	IN
cord-000238-om92cx5q	284	26	the	the	DT
cord-000238-om92cx5q	284	27	establishment	establishment	NN
cord-000238-om92cx5q	284	28	of	of	IN
cord-000238-om92cx5q	284	29	a	a	DT
cord-000238-om92cx5q	284	30	clinical	clinical	JJ
cord-000238-om92cx5q	284	31	infection	infection	NN
cord-000238-om92cx5q	284	32	.	.	.
cord-000238-om92cx5q	285	1	62	62	CD
cord-000238-om92cx5q	285	2	,	,	,
cord-000238-om92cx5q	285	3	63	63	CD
cord-000238-om92cx5q	286	1	Thus	thus	RB
cord-000238-om92cx5q	286	2	,	,	,
cord-000238-om92cx5q	286	3	many	many	JJ
cord-000238-om92cx5q	286	4	therapeutic	therapeutic	JJ
cord-000238-om92cx5q	286	5	measures	measure	NNS
cord-000238-om92cx5q	286	6	against	against	IN
cord-000238-om92cx5q	286	7	a	a	DT
cord-000238-om92cx5q	286	8	variety	variety	NN
cord-000238-om92cx5q	286	9	of	of	IN
cord-000238-om92cx5q	286	10	pathogens	pathogen	NNS
cord-000238-om92cx5q	286	11	rely	rely	VBP
cord-000238-om92cx5q	286	12	on	on	IN
cord-000238-om92cx5q	286	13	this	this	DT
cord-000238-om92cx5q	286	14	vital	vital	JJ
cord-000238-om92cx5q	286	15	receptor	receptor	NN
cord-000238-om92cx5q	286	16	-	-	HYPH
cord-000238-om92cx5q	286	17	ligand	ligand	NN
cord-000238-om92cx5q	286	18	interaction	interaction	NN
cord-000238-om92cx5q	286	19	.	.	.
cord-000238-om92cx5q	287	1	Virus	virus	NN
cord-000238-om92cx5q	287	2	examples	example	NNS
cord-000238-om92cx5q	287	3	include	include	VBP
cord-000238-om92cx5q	287	4	the	the	DT
cord-000238-om92cx5q	287	5	seasonal	seasonal	JJ
cord-000238-om92cx5q	287	6	influenza	influenza	NN
cord-000238-om92cx5q	287	7	vaccine	vaccine	NN
cord-000238-om92cx5q	287	8	,	,	,
cord-000238-om92cx5q	287	9	and	and	CC
cord-000238-om92cx5q	287	10	fusion	fusion	NN
cord-000238-om92cx5q	287	11	inhibitor	inhibitor	NN
cord-000238-om92cx5q	287	12	compounds	compound	NNS
cord-000238-om92cx5q	287	13	,	,	,
cord-000238-om92cx5q	287	14	a	a	DT
cord-000238-om92cx5q	287	15	class	class	NN
cord-000238-om92cx5q	287	16	of	of	IN
cord-000238-om92cx5q	287	17	anti	anti	JJ
cord-000238-om92cx5q	287	18	-	-	JJ
cord-000238-om92cx5q	287	19	HIV	hiv	JJ
cord-000238-om92cx5q	287	20	therapies	therapy	NNS
cord-000238-om92cx5q	287	21	.	.	.
cord-000238-om92cx5q	288	1	64	64	CD
cord-000238-om92cx5q	288	2	,	,	,
cord-000238-om92cx5q	288	3	65	65	CD
cord-000238-om92cx5q	289	1	In	in	IN
cord-000238-om92cx5q	289	2	nonvirus	nonvirus	NNP
cord-000238-om92cx5q	289	3	parasites	parasite	NNS
cord-000238-om92cx5q	289	4	the	the	DT
cord-000238-om92cx5q	289	5	situation	situation	NN
cord-000238-om92cx5q	289	6	is	be	VBZ
cord-000238-om92cx5q	289	7	more	more	RBR
cord-000238-om92cx5q	289	8	complicated	complicated	JJ
cord-000238-om92cx5q	289	9	,	,	,
cord-000238-om92cx5q	289	10	because	because	IN
cord-000238-om92cx5q	289	11	the	the	DT
cord-000238-om92cx5q	289	12	process	process	NN
cord-000238-om92cx5q	289	13	of	of	IN
cord-000238-om92cx5q	289	14	invasion	invasion	NN
cord-000238-om92cx5q	289	15	is	be	VBZ
cord-000238-om92cx5q	289	16	a	a	DT
cord-000238-om92cx5q	289	17	complex	complex	JJ
cord-000238-om92cx5q	289	18	module	module	NN
cord-000238-om92cx5q	289	19	involving	involve	VBG
cord-000238-om92cx5q	289	20	several	several	JJ
cord-000238-om92cx5q	289	21	different	different	JJ
cord-000238-om92cx5q	289	22	effectors	effector	NNS
cord-000238-om92cx5q	289	23	.	.	.
cord-000238-om92cx5q	290	1	One	one	CD
cord-000238-om92cx5q	290	2	possible	possible	JJ
cord-000238-om92cx5q	290	3	example	example	NN
cord-000238-om92cx5q	290	4	of	of	IN
cord-000238-om92cx5q	290	5	a	a	DT
cord-000238-om92cx5q	290	6	robust	robust	JJ
cord-000238-om92cx5q	290	7	invasion	invasion	NN
cord-000238-om92cx5q	290	8	module	module	NN
cord-000238-om92cx5q	290	9	is	be	VBZ
cord-000238-om92cx5q	290	10	in	in	IN
cord-000238-om92cx5q	290	11	Plasmodium	Plasmodium	NNP
cord-000238-om92cx5q	290	12	falciparum	falciparum	NN
cord-000238-om92cx5q	290	13	,	,	,
cord-000238-om92cx5q	290	14	the	the	DT
cord-000238-om92cx5q	290	15	causative	causative	JJ
cord-000238-om92cx5q	290	16	agent	agent	NN
cord-000238-om92cx5q	290	17	of	of	IN
cord-000238-om92cx5q	290	18	the	the	DT
cord-000238-om92cx5q	290	19	most	most	RBS
cord-000238-om92cx5q	290	20	deadly	deadly	JJ
cord-000238-om92cx5q	290	21	form	form	NN
cord-000238-om92cx5q	290	22	of	of	IN
cord-000238-om92cx5q	290	23	human	human	JJ
cord-000238-om92cx5q	290	24	malaria	malaria	NN
cord-000238-om92cx5q	290	25	.	.	.
cord-000238-om92cx5q	291	1	In	in	IN
cord-000238-om92cx5q	291	2	P.	P.	NNP
cord-000238-om92cx5q	291	3	falciparum	falciparum	NN
cord-000238-om92cx5q	291	4	and	and	CC
cord-000238-om92cx5q	291	5	the	the	DT
cord-000238-om92cx5q	291	6	apicomplexan	apicomplexan	NNP
cord-000238-om92cx5q	291	7	parasites	parasites	NNP
cord-000238-om92cx5q	291	8	,	,	,
cord-000238-om92cx5q	291	9	an	an	DT
cord-000238-om92cx5q	291	10	apical	apical	JJ
cord-000238-om92cx5q	291	11	complex	complex	NN
cord-000238-om92cx5q	291	12	is	be	VBZ
cord-000238-om92cx5q	291	13	central	central	JJ
cord-000238-om92cx5q	291	14	to	to	IN
cord-000238-om92cx5q	291	15	the	the	DT
cord-000238-om92cx5q	291	16	invasion	invasion	NN
cord-000238-om92cx5q	291	17	process	process	NN
cord-000238-om92cx5q	291	18	,	,	,
cord-000238-om92cx5q	291	19	which	which	WDT
cord-000238-om92cx5q	291	20	includes	include	VBZ
cord-000238-om92cx5q	291	21	multiple	multiple	JJ
cord-000238-om92cx5q	291	22	steps	step	NNS
cord-000238-om92cx5q	291	23	involving	involve	VBG
cord-000238-om92cx5q	291	24	protein	protein	NN
cord-000238-om92cx5q	291	25	interactions	interaction	NNS
cord-000238-om92cx5q	291	26	and	and	CC
cord-000238-om92cx5q	291	27	temporally	temporally	RB
cord-000238-om92cx5q	291	28	and	and	CC
cord-000238-om92cx5q	291	29	spatially	spatially	RB
cord-000238-om92cx5q	291	30	regulated	regulated	JJ
cord-000238-om92cx5q	291	31	expression	expression	NN
cord-000238-om92cx5q	291	32	of	of	IN
cord-000238-om92cx5q	291	33	proteases	protease	NNS
cord-000238-om92cx5q	291	34	and	and	CC
cord-000238-om92cx5q	291	35	polymerization	polymerization	NN
cord-000238-om92cx5q	291	36	machinery	machinery	NN
cord-000238-om92cx5q	291	37	.	.	.
cord-000238-om92cx5q	292	1	63	63	CD
cord-000238-om92cx5q	292	2	,	,	,
cord-000238-om92cx5q	292	3	66	66	CD
cord-000238-om92cx5q	292	4	,	,	,
cord-000238-om92cx5q	292	5	67	67	CD
cord-000238-om92cx5q	293	1	Given	give	VBN
cord-000238-om92cx5q	293	2	the	the	DT
cord-000238-om92cx5q	293	3	importance	importance	NN
cord-000238-om92cx5q	293	4	of	of	IN
cord-000238-om92cx5q	293	5	erythrocytes	erythrocyte	NNS
cord-000238-om92cx5q	293	6	as	as	IN
cord-000238-om92cx5q	293	7	cells	cell	NNS
cord-000238-om92cx5q	293	8	where	where	WRB
cord-000238-om92cx5q	293	9	parasite	parasite	NN
cord-000238-om92cx5q	293	10	replication	replication	NN
cord-000238-om92cx5q	293	11	occurs	occur	VBZ
cord-000238-om92cx5q	293	12	,	,	,
cord-000238-om92cx5q	293	13	one	one	PRP
cord-000238-om92cx5q	293	14	might	may	MD
cord-000238-om92cx5q	293	15	expect	expect	VB
cord-000238-om92cx5q	293	16	that	that	IN
cord-000238-om92cx5q	293	17	P.	p.	NN
cord-000238-om92cx5q	293	18	falciparum	falciparum	NN
cord-000238-om92cx5q	293	19	interactions	interaction	NNS
cord-000238-om92cx5q	293	20	with	with	IN
cord-000238-om92cx5q	293	21	erythrocytes	erythrocyte	NNS
cord-000238-om92cx5q	293	22	should	should	MD
cord-000238-om92cx5q	293	23	be	be	VB
cord-000238-om92cx5q	293	24	particularly	particularly	RB
cord-000238-om92cx5q	293	25	critical	critical	JJ
cord-000238-om92cx5q	293	26	in	in	IN
cord-000238-om92cx5q	293	27	a	a	DT
cord-000238-om92cx5q	293	28	robustness	robustness	NN
cord-000238-om92cx5q	293	29	module	module	NN
cord-000238-om92cx5q	293	30	for	for	IN
cord-000238-om92cx5q	293	31	the	the	DT
cord-000238-om92cx5q	293	32	FIG	fig	NN
cord-000238-om92cx5q	293	33	.	.	.
cord-000238-om92cx5q	294	1	3	3	LS
cord-000238-om92cx5q	294	2	.	.	.
cord-000238-om92cx5q	295	1	͑Color	͑Color	.
cord-000238-om92cx5q	296	1	online͒	online͒	NNP
cord-000238-om92cx5q	296	2	Robustness	Robustness	NNP
cord-000238-om92cx5q	296	3	in	in	IN
cord-000238-om92cx5q	296	4	gene	gene	NN
cord-000238-om92cx5q	296	5	networks	network	NNS
cord-000238-om92cx5q	296	6	of	of	IN
cord-000238-om92cx5q	296	7	influenza	influenza	NN
cord-000238-om92cx5q	296	8	A	a	DT
cord-000238-om92cx5q	296	9	HA	HA	NNP
cord-000238-om92cx5q	296	10	genes	gene	NNS
cord-000238-om92cx5q	296	11	.	.	.
cord-000238-om92cx5q	297	1	Phenotypes	phenotype	NNS
cord-000238-om92cx5q	297	2	are	be	VBP
cord-000238-om92cx5q	297	3	genetically	genetically	RB
cord-000238-om92cx5q	297	4	robust	robust	JJ
cord-000238-om92cx5q	297	5	,	,	,
cord-000238-om92cx5q	297	6	allowing	allow	VBG
cord-000238-om92cx5q	297	7	genotypes	genotype	NNS
cord-000238-om92cx5q	297	8	to	to	TO
cord-000238-om92cx5q	297	9	drift	drift	VB
cord-000238-om92cx5q	297	10	through	through	IN
cord-000238-om92cx5q	297	11	genotypic	genotypic	JJ
cord-000238-om92cx5q	297	12	neutral	neutral	JJ
cord-000238-om92cx5q	297	13	space	space	NN
cord-000238-om92cx5q	297	14	before	before	IN
cord-000238-om92cx5q	297	15	instant	instant	JJ
cord-000238-om92cx5q	297	16	shifts	shift	NNS
cord-000238-om92cx5q	297	17	in	in	IN
cord-000238-om92cx5q	297	18	phenotype	phenotype	NN
cord-000238-om92cx5q	297	19	.	.	.
cord-000238-om92cx5q	298	1	Such	such	PDT
cord-000238-om92cx5q	298	2	a	a	DT
cord-000238-om92cx5q	298	3	scenario	scenario	NN
cord-000238-om92cx5q	298	4	is	be	VBZ
cord-000238-om92cx5q	298	5	a	a	DT
cord-000238-om92cx5q	298	6	demonstration	demonstration	NN
cord-000238-om92cx5q	298	7	,	,	,
cord-000238-om92cx5q	298	8	from	from	IN
cord-000238-om92cx5q	298	9	the	the	DT
cord-000238-om92cx5q	298	10	actual	actual	JJ
cord-000238-om92cx5q	298	11	epidemiological	epidemiological	JJ
cord-000238-om92cx5q	298	12	literature	literature	NN
cord-000238-om92cx5q	298	13	,	,	,
cord-000238-om92cx5q	298	14	of	of	IN
cord-000238-om92cx5q	298	15	how	how	WRB
cord-000238-om92cx5q	298	16	genetic	genetic	JJ
cord-000238-om92cx5q	298	17	robustness	robustness	NN
cord-000238-om92cx5q	298	18	can	can	MD
cord-000238-om92cx5q	298	19	facilitate	facilitate	VB
cord-000238-om92cx5q	298	20	evolvability	evolvability	NN
cord-000238-om92cx5q	298	21	in	in	IN
cord-000238-om92cx5q	298	22	infectious	infectious	JJ
cord-000238-om92cx5q	298	23	disease	disease	NN
cord-000238-om92cx5q	298	24	agents	agent	NNS
cord-000238-om92cx5q	298	25	.	.	.
cord-000238-om92cx5q	299	1	͓From	͓from	IN
cord-000238-om92cx5q	299	2	E.	E.	NNP
cord-000238-om92cx5q	299	3	van	van	NNP
cord-000238-om92cx5q	299	4	Nimwegen	Nimwegen	NNP
cord-000238-om92cx5q	299	5	,	,	,
cord-000238-om92cx5q	299	6	Science	Science	NNP
cord-000238-om92cx5q	299	7	314	314	CD
cord-000238-om92cx5q	299	8	,	,	,
cord-000238-om92cx5q	299	9	1884	1884	CD
cord-000238-om92cx5q	299	10	,	,	,
cord-000238-om92cx5q	299	11	2006	2006	CD
cord-000238-om92cx5q	299	12	.	.	.
cord-000238-om92cx5q	300	1	Reprinted	reprint	VBN
cord-000238-om92cx5q	300	2	with	with	IN
cord-000238-om92cx5q	300	3	permission	permission	NN
cord-000238-om92cx5q	300	4	from	from	IN
cord-000238-om92cx5q	300	5	AAAS.͔	AAAS.͔	NNP
cord-000238-om92cx5q	300	6	pathogen	pathogen	NN
cord-000238-om92cx5q	300	7	.	.	.
cord-000238-om92cx5q	301	1	In	in	IN
cord-000238-om92cx5q	301	2	fact	fact	NN
cord-000238-om92cx5q	301	3	,	,	,
cord-000238-om92cx5q	301	4	studies	study	NNS
cord-000238-om92cx5q	301	5	show	show	VBP
cord-000238-om92cx5q	301	6	that	that	IN
cord-000238-om92cx5q	301	7	the	the	DT
cord-000238-om92cx5q	301	8	erythrocyteattachment	erythrocyteattachment	NN
cord-000238-om92cx5q	301	9	process	process	NN
cord-000238-om92cx5q	301	10	involves	involve	VBZ
cord-000238-om92cx5q	301	11	redundancy	redundancy	NN
cord-000238-om92cx5q	301	12	in	in	IN
cord-000238-om92cx5q	301	13	ligands	ligand	NNS
cord-000238-om92cx5q	301	14	used	use	VBN
cord-000238-om92cx5q	301	15	for	for	IN
cord-000238-om92cx5q	301	16	binding	bind	VBG
cord-000238-om92cx5q	301	17	of	of	IN
cord-000238-om92cx5q	301	18	the	the	DT
cord-000238-om92cx5q	301	19	pathogen	pathogen	NN
cord-000238-om92cx5q	301	20	to	to	IN
cord-000238-om92cx5q	301	21	erythrocyte	erythrocyte	NN
cord-000238-om92cx5q	301	22	receptors	receptor	NNS
cord-000238-om92cx5q	301	23	.	.	.
cord-000238-om92cx5q	302	1	68	68	CD
cord-000238-om92cx5q	302	2	,	,	,
cord-000238-om92cx5q	302	3	62	62	CD
cord-000238-om92cx5q	303	1	This	this	DT
cord-000238-om92cx5q	303	2	evolved	evolve	VBD
cord-000238-om92cx5q	303	3	strategy	strategy	NN
cord-000238-om92cx5q	303	4	might	may	MD
cord-000238-om92cx5q	303	5	have	have	VB
cord-000238-om92cx5q	303	6	been	be	VBN
cord-000238-om92cx5q	303	7	selected	select	VBN
cord-000238-om92cx5q	303	8	in	in	IN
cord-000238-om92cx5q	303	9	P.	P.	NNP
cord-000238-om92cx5q	303	10	falciparum	falciparum	NN
cord-000238-om92cx5q	303	11	because	because	IN
cord-000238-om92cx5q	303	12	erythrocyte	erythrocyte	NN
cord-000238-om92cx5q	303	13	receptors	receptor	NNS
cord-000238-om92cx5q	303	14	are	be	VBP
cord-000238-om92cx5q	303	15	highly	highly	RB
cord-000238-om92cx5q	303	16	polymorphic	polymorphic	JJ
cord-000238-om92cx5q	303	17	,	,	,
cord-000238-om92cx5q	303	18	perhaps	perhaps	RB
cord-000238-om92cx5q	303	19	among	among	IN
cord-000238-om92cx5q	303	20	the	the	DT
cord-000238-om92cx5q	303	21	fastest	fast	JJS
cord-000238-om92cx5q	303	22	evolving	evolve	VBG
cord-000238-om92cx5q	303	23	genes	gene	NNS
cord-000238-om92cx5q	303	24	in	in	IN
cord-000238-om92cx5q	303	25	the	the	DT
cord-000238-om92cx5q	303	26	human	human	JJ
cord-000238-om92cx5q	303	27	genome	genome	NN
cord-000238-om92cx5q	303	28	.	.	.
cord-000238-om92cx5q	304	1	69	69	CD
cord-000238-om92cx5q	304	2	,	,	,
cord-000238-om92cx5q	304	3	70	70	CD
cord-000238-om92cx5q	304	4	Research	Research	NNP
cord-000238-om92cx5q	304	5	shows	show	VBZ
cord-000238-om92cx5q	304	6	that	that	IN
cord-000238-om92cx5q	304	7	P.	P.	NNP
cord-000238-om92cx5q	304	8	falciparum	falciparum	NN
cord-000238-om92cx5q	304	9	utilizes	utilize	VBZ
cord-000238-om92cx5q	304	10	a	a	DT
cord-000238-om92cx5q	304	11	plethora	plethora	NN
cord-000238-om92cx5q	304	12	of	of	IN
cord-000238-om92cx5q	304	13	ligands	ligand	NNS
cord-000238-om92cx5q	304	14	to	to	TO
cord-000238-om92cx5q	304	15	bind	bind	VB
cord-000238-om92cx5q	304	16	erythrocyte	erythrocyte	NN
cord-000238-om92cx5q	304	17	receptors	receptor	NNS
cord-000238-om92cx5q	304	18	.	.	.
cord-000238-om92cx5q	305	1	62	62	CD
cord-000238-om92cx5q	305	2	,	,	,
cord-000238-om92cx5q	305	3	68	68	CD
cord-000238-om92cx5q	305	4	,	,	,
cord-000238-om92cx5q	305	5	70	70	CD
cord-000238-om92cx5q	306	1	Interestingly	interestingly	RB
cord-000238-om92cx5q	306	2	,	,	,
cord-000238-om92cx5q	306	3	a	a	DT
cord-000238-om92cx5q	306	4	"	"	``
cord-000238-om92cx5q	306	5	molecular	molecular	JJ
cord-000238-om92cx5q	306	6	hierarchy	hierarchy	NN
cord-000238-om92cx5q	306	7	"	"	''
cord-000238-om92cx5q	306	8	may	may	MD
cord-000238-om92cx5q	306	9	be	be	VB
cord-000238-om92cx5q	306	10	the	the	DT
cord-000238-om92cx5q	306	11	ideal	ideal	JJ
cord-000238-om92cx5q	306	12	term	term	NN
cord-000238-om92cx5q	306	13	to	to	TO
cord-000238-om92cx5q	306	14	describe	describe	VB
cord-000238-om92cx5q	306	15	ligand	ligand	NN
cord-000238-om92cx5q	306	16	usage	usage	NN
cord-000238-om92cx5q	306	17	in	in	IN
cord-000238-om92cx5q	306	18	P.	P.	NNP
cord-000238-om92cx5q	306	19	falciparum	falciparum	NN
cord-000238-om92cx5q	306	20	;	;	:
cord-000238-om92cx5q	306	21	the	the	DT
cord-000238-om92cx5q	306	22	pathogen	pathogen	NN
cord-000238-om92cx5q	306	23	's	's	POS
cord-000238-om92cx5q	306	24	invasion	invasion	NN
cord-000238-om92cx5q	306	25	module	module	NN
cord-000238-om92cx5q	306	26	may	may	MD
cord-000238-om92cx5q	306	27	consist	consist	VB
cord-000238-om92cx5q	306	28	of	of	IN
cord-000238-om92cx5q	306	29	a	a	DT
cord-000238-om92cx5q	306	30	hierarchy	hierarchy	NN
cord-000238-om92cx5q	306	31	whereby	whereby	WRB
cord-000238-om92cx5q	306	32	some	some	DT
cord-000238-om92cx5q	306	33	ligands	ligand	NNS
cord-000238-om92cx5q	306	34	used	use	VBN
cord-000238-om92cx5q	306	35	in	in	IN
cord-000238-om92cx5q	306	36	attachment	attachment	NN
cord-000238-om92cx5q	306	37	are	be	VBP
cord-000238-om92cx5q	306	38	preferred	prefer	VBN
cord-000238-om92cx5q	306	39	over	over	IN
cord-000238-om92cx5q	306	40	others	other	NNS
cord-000238-om92cx5q	306	41	,	,	,
cord-000238-om92cx5q	306	42	with	with	IN
cord-000238-om92cx5q	306	43	the	the	DT
cord-000238-om92cx5q	306	44	switch	switch	NN
cord-000238-om92cx5q	306	45	in	in	IN
cord-000238-om92cx5q	306	46	usage	usage	NN
cord-000238-om92cx5q	306	47	only	only	RB
cord-000238-om92cx5q	306	48	taking	take	VBG
cord-000238-om92cx5q	306	49	place	place	NN
cord-000238-om92cx5q	306	50	when	when	WRB
cord-000238-om92cx5q	306	51	a	a	DT
cord-000238-om92cx5q	306	52	ligand	ligand	NN
cord-000238-om92cx5q	306	53	higher	high	JJR
cord-000238-om92cx5q	306	54	up	up	RB
cord-000238-om92cx5q	306	55	in	in	IN
cord-000238-om92cx5q	306	56	the	the	DT
cord-000238-om92cx5q	306	57	hierarchy	hierarchy	NN
cord-000238-om92cx5q	306	58	is	be	VBZ
cord-000238-om92cx5q	306	59	ineffective	ineffective	JJ
cord-000238-om92cx5q	306	60	͑Fig	͑Fig	NNS
cord-000238-om92cx5q	306	61	.	.	.
cord-000238-om92cx5q	307	1	4͒.	4͒.	CD
cord-000238-om92cx5q	308	1	68	68	CD
cord-000238-om92cx5q	309	1	This	this	DT
cord-000238-om92cx5q	309	2	observation	observation	NN
cord-000238-om92cx5q	309	3	may	may	MD
cord-000238-om92cx5q	309	4	be	be	VB
cord-000238-om92cx5q	309	5	usefully	usefully	RB
cord-000238-om92cx5q	309	6	couched	couch	VBN
cord-000238-om92cx5q	309	7	in	in	IN
cord-000238-om92cx5q	309	8	terms	term	NNS
cord-000238-om92cx5q	309	9	of	of	IN
cord-000238-om92cx5q	309	10	robustness	robustness	NN
cord-000238-om92cx5q	309	11	,	,	,
cord-000238-om92cx5q	309	12	because	because	IN
cord-000238-om92cx5q	309	13	redundancy	redundancy	NN
cord-000238-om92cx5q	309	14	is	be	VBZ
cord-000238-om92cx5q	309	15	a	a	DT
cord-000238-om92cx5q	309	16	possible	possible	JJ
cord-000238-om92cx5q	309	17	mechanism	mechanism	NN
cord-000238-om92cx5q	309	18	for	for	IN
cord-000238-om92cx5q	309	19	constructing	construct	VBG
cord-000238-om92cx5q	309	20	a	a	DT
cord-000238-om92cx5q	309	21	robust	robust	JJ
cord-000238-om92cx5q	309	22	biological	biological	JJ
cord-000238-om92cx5q	309	23	system	system	NN
cord-000238-om92cx5q	309	24	.	.	.
cord-000238-om92cx5q	310	1	To	to	TO
cord-000238-om92cx5q	310	2	ensure	ensure	VB
cord-000238-om92cx5q	310	3	that	that	IN
cord-000238-om92cx5q	310	4	an	an	DT
cord-000238-om92cx5q	310	5	essential	essential	JJ
cord-000238-om92cx5q	310	6	function	function	NN
cord-000238-om92cx5q	310	7	is	be	VBZ
cord-000238-om92cx5q	310	8	carried	carry	VBN
cord-000238-om92cx5q	310	9	out	out	RP
cord-000238-om92cx5q	310	10	,	,	,
cord-000238-om92cx5q	310	11	a	a	DT
cord-000238-om92cx5q	310	12	biological	biological	JJ
cord-000238-om92cx5q	310	13	system	system	NN
cord-000238-om92cx5q	310	14	can	can	MD
cord-000238-om92cx5q	310	15	be	be	VB
cord-000238-om92cx5q	310	16	organized	organize	VBN
cord-000238-om92cx5q	310	17	to	to	TO
cord-000238-om92cx5q	310	18	contain	contain	VB
cord-000238-om92cx5q	310	19	several	several	JJ
cord-000238-om92cx5q	310	20	alternative	alternative	JJ
cord-000238-om92cx5q	310	21	pathways	pathway	NNS
cord-000238-om92cx5q	310	22	in	in	IN
cord-000238-om92cx5q	310	23	the	the	DT
cord-000238-om92cx5q	310	24	event	event	NN
cord-000238-om92cx5q	310	25	that	that	WDT
cord-000238-om92cx5q	310	26	one	one	CD
cord-000238-om92cx5q	310	27	or	or	CC
cord-000238-om92cx5q	310	28	more	more	RBR
cord-000238-om92cx5q	310	29	become	become	VBN
cord-000238-om92cx5q	310	30	unavailable	unavailable	JJ
cord-000238-om92cx5q	310	31	or	or	CC
cord-000238-om92cx5q	310	32	dysfunctional	dysfunctional	JJ
cord-000238-om92cx5q	310	33	.	.	.
cord-000238-om92cx5q	311	1	This	this	DT
cord-000238-om92cx5q	311	2	evolved	evolve	VBD
cord-000238-om92cx5q	311	3	strategy	strategy	NN
cord-000238-om92cx5q	311	4	decreases	decrease	VBZ
cord-000238-om92cx5q	311	5	the	the	DT
cord-000238-om92cx5q	311	6	probability	probability	NN
cord-000238-om92cx5q	311	7	that	that	IN
cord-000238-om92cx5q	311	8	an	an	DT
cord-000238-om92cx5q	311	9	environmental	environmental	JJ
cord-000238-om92cx5q	311	10	perturbation	perturbation	NN
cord-000238-om92cx5q	311	11	disrupts	disrupt	VBZ
cord-000238-om92cx5q	311	12	performance	performance	NN
cord-000238-om92cx5q	311	13	.	.	.
cord-000238-om92cx5q	312	1	The	the	DT
cord-000238-om92cx5q	312	2	concept	concept	NN
cord-000238-om92cx5q	312	3	of	of	IN
cord-000238-om92cx5q	312	4	robustness	robustness	NN
cord-000238-om92cx5q	312	5	has	have	VBZ
cord-000238-om92cx5q	312	6	the	the	DT
cord-000238-om92cx5q	312	7	continued	continue	VBN
cord-000238-om92cx5q	312	8	potential	potential	NN
cord-000238-om92cx5q	312	9	to	to	TO
cord-000238-om92cx5q	312	10	shift	shift	VB
cord-000238-om92cx5q	312	11	paradigms	paradigm	NNS
cord-000238-om92cx5q	312	12	in	in	IN
cord-000238-om92cx5q	312	13	biology	biology	NN
cord-000238-om92cx5q	312	14	by	by	IN
cord-000238-om92cx5q	312	15	challenging	challenge	VBG
cord-000238-om92cx5q	312	16	assumed	assume	VBN
cord-000238-om92cx5q	312	17	relationships	relationship	NNS
cord-000238-om92cx5q	312	18	between	between	IN
cord-000238-om92cx5q	312	19	genotypes	genotype	NNS
cord-000238-om92cx5q	312	20	and	and	CC
cord-000238-om92cx5q	312	21	phenotypes	phenotype	NNS
cord-000238-om92cx5q	312	22	.	.	.
cord-000238-om92cx5q	313	1	Here	here	RB
cord-000238-om92cx5q	313	2	we	-PRON-	PRP
cord-000238-om92cx5q	313	3	have	have	VBP
cord-000238-om92cx5q	313	4	highlighted	highlight	VBN
cord-000238-om92cx5q	313	5	some	some	DT
cord-000238-om92cx5q	313	6	of	of	IN
cord-000238-om92cx5q	313	7	the	the	DT
cord-000238-om92cx5q	313	8	empirical	empirical	JJ
cord-000238-om92cx5q	313	9	evidence	evidence	NN
cord-000238-om92cx5q	313	10	for	for	IN
cord-000238-om92cx5q	313	11	evolution	evolution	NN
cord-000238-om92cx5q	313	12	of	of	IN
cord-000238-om92cx5q	313	13	robustness	robustness	NN
cord-000238-om92cx5q	313	14	,	,	,
cord-000238-om92cx5q	313	15	and	and	CC
cord-000238-om92cx5q	313	16	discussed	discuss	VBD
cord-000238-om92cx5q	313	17	its	-PRON-	PRP$
cord-000238-om92cx5q	313	18	relevance	relevance	NN
cord-000238-om92cx5q	313	19	for	for	IN
cord-000238-om92cx5q	313	20	evolution	evolution	NN
cord-000238-om92cx5q	313	21	of	of	IN
cord-000238-om92cx5q	313	22	infectious	infectious	JJ
cord-000238-om92cx5q	313	23	diseases	disease	NNS
cord-000238-om92cx5q	313	24	,	,	,
cord-000238-om92cx5q	313	25	particularly	particularly	RB
cord-000238-om92cx5q	313	26	in	in	IN
cord-000238-om92cx5q	313	27	humans	human	NNS
cord-000238-om92cx5q	313	28	.	.	.
cord-000238-om92cx5q	314	1	Despite	despite	IN
cord-000238-om92cx5q	314	2	the	the	DT
cord-000238-om92cx5q	314	3	widereaching	widereaching	JJ
cord-000238-om92cx5q	314	4	importance	importance	NN
cord-000238-om92cx5q	314	5	of	of	IN
cord-000238-om92cx5q	314	6	robustness	robustness	NN
cord-000238-om92cx5q	314	7	theory	theory	NN
cord-000238-om92cx5q	314	8	in	in	IN
cord-000238-om92cx5q	314	9	biology	biology	NN
cord-000238-om92cx5q	314	10	and	and	CC
cord-000238-om92cx5q	314	11	other	other	JJ
cord-000238-om92cx5q	314	12	disciplines	discipline	NNS
cord-000238-om92cx5q	314	13	,	,	,
cord-000238-om92cx5q	314	14	we	-PRON-	PRP
cord-000238-om92cx5q	314	15	emphasize	emphasize	VBP
cord-000238-om92cx5q	314	16	that	that	IN
cord-000238-om92cx5q	314	17	the	the	DT
cord-000238-om92cx5q	314	18	origins	origin	NNS
cord-000238-om92cx5q	314	19	and	and	CC
cord-000238-om92cx5q	314	20	implications	implication	NNS
cord-000238-om92cx5q	314	21	of	of	IN
cord-000238-om92cx5q	314	22	robustness	robustness	NN
cord-000238-om92cx5q	314	23	may	may	MD
cord-000238-om92cx5q	314	24	be	be	VB
cord-000238-om92cx5q	314	25	highly	highly	RB
cord-000238-om92cx5q	314	26	context	context	JJ
cord-000238-om92cx5q	314	27	specific	specific	JJ
cord-000238-om92cx5q	314	28	.	.	.
cord-000238-om92cx5q	315	1	The	the	DT
cord-000238-om92cx5q	315	2	underlying	underlie	VBG
cord-000238-om92cx5q	315	3	causes	cause	NNS
cord-000238-om92cx5q	315	4	of	of	IN
cord-000238-om92cx5q	315	5	diseases	disease	NNS
cord-000238-om92cx5q	315	6	in	in	IN
cord-000238-om92cx5q	315	7	humans	human	NNS
cord-000238-om92cx5q	315	8	and	and	CC
cord-000238-om92cx5q	315	9	other	other	JJ
cord-000238-om92cx5q	315	10	organisms	organism	NNS
cord-000238-om92cx5q	315	11	are	be	VBP
cord-000238-om92cx5q	315	12	manifold	manifold	JJ
cord-000238-om92cx5q	315	13	.	.	.
cord-000238-om92cx5q	316	1	To	to	TO
cord-000238-om92cx5q	316	2	wield	wield	VB
cord-000238-om92cx5q	316	3	the	the	DT
cord-000238-om92cx5q	316	4	robustness	robustness	NN
cord-000238-om92cx5q	316	5	concept	concept	NN
cord-000238-om92cx5q	316	6	effectively	effectively	RB
cord-000238-om92cx5q	316	7	in	in	IN
cord-000238-om92cx5q	316	8	the	the	DT
cord-000238-om92cx5q	316	9	evolution	evolution	NN
cord-000238-om92cx5q	316	10	of	of	IN
cord-000238-om92cx5q	316	11	infectious	infectious	JJ
cord-000238-om92cx5q	316	12	diseases	disease	NNS
cord-000238-om92cx5q	316	13	,	,	,
cord-000238-om92cx5q	316	14	sufficient	sufficient	JJ
cord-000238-om92cx5q	316	15	understanding	understanding	NN
cord-000238-om92cx5q	316	16	of	of	IN
cord-000238-om92cx5q	316	17	how	how	WRB
cord-000238-om92cx5q	316	18	ecological	ecological	JJ
cord-000238-om92cx5q	316	19	history	history	NN
cord-000238-om92cx5q	316	20	might	may	MD
cord-000238-om92cx5q	316	21	have	have	VB
cord-000238-om92cx5q	316	22	selected	select	VBN
cord-000238-om92cx5q	316	23	for	for	IN
cord-000238-om92cx5q	316	24	robustness	robustness	NN
cord-000238-om92cx5q	316	25	is	be	VBZ
cord-000238-om92cx5q	316	26	warranted	warrant	VBN
cord-000238-om92cx5q	316	27	.	.	.
cord-000238-om92cx5q	317	1	Robustness	robustness	NN
cord-000238-om92cx5q	317	2	has	have	VBZ
cord-000238-om92cx5q	317	3	often	often	RB
cord-000238-om92cx5q	317	4	resided	reside	VBN
cord-000238-om92cx5q	317	5	in	in	IN
cord-000238-om92cx5q	317	6	the	the	DT
cord-000238-om92cx5q	317	7	realm	realm	NN
cord-000238-om92cx5q	317	8	of	of	IN
cord-000238-om92cx5q	317	9	mathematical	mathematical	JJ
cord-000238-om92cx5q	317	10	theory	theory	NN
cord-000238-om92cx5q	317	11	,	,	,
cord-000238-om92cx5q	317	12	but	but	CC
cord-000238-om92cx5q	317	13	future	future	JJ
cord-000238-om92cx5q	317	14	work	work	NN
cord-000238-om92cx5q	317	15	would	would	MD
cord-000238-om92cx5q	317	16	benefit	benefit	VB
cord-000238-om92cx5q	317	17	from	from	IN
cord-000238-om92cx5q	317	18	col	col	NNP
cord-000238-om92cx5q	317	19	-	-	HYPH
cord-000238-om92cx5q	317	20	laborations	laboration	NNS
cord-000238-om92cx5q	317	21	between	between	IN
cord-000238-om92cx5q	317	22	empiricists	empiricist	NNS
cord-000238-om92cx5q	317	23	and	and	CC
cord-000238-om92cx5q	317	24	theoreticians	theoretician	NNS
cord-000238-om92cx5q	317	25	to	to	TO
cord-000238-om92cx5q	317	26	test	test	VB
cord-000238-om92cx5q	317	27	explicitly	explicitly	RB
cord-000238-om92cx5q	317	28	predictions	prediction	NNS
cord-000238-om92cx5q	317	29	using	use	VBG
cord-000238-om92cx5q	317	30	tractable	tractable	JJ
cord-000238-om92cx5q	317	31	models	model	NNS
cord-000238-om92cx5q	317	32	,	,	,
cord-000238-om92cx5q	317	33	or	or	CC
cord-000238-om92cx5q	317	34	disease	disease	NN
cord-000238-om92cx5q	317	35	pathogens	pathogen	NNS
cord-000238-om92cx5q	317	36	.	.	.
cord-000238-om92cx5q	318	1	These	these	DT
cord-000238-om92cx5q	318	2	efforts	effort	NNS
cord-000238-om92cx5q	318	3	would	would	MD
cord-000238-om92cx5q	318	4	help	help	VB
cord-000238-om92cx5q	318	5	to	to	TO
cord-000238-om92cx5q	318	6	elucidate	elucidate	VB
cord-000238-om92cx5q	318	7	further	further	RB
cord-000238-om92cx5q	318	8	the	the	DT
cord-000238-om92cx5q	318	9	role	role	NN
cord-000238-om92cx5q	318	10	of	of	IN
cord-000238-om92cx5q	318	11	robustness	robustness	NN
cord-000238-om92cx5q	318	12	in	in	IN
cord-000238-om92cx5q	318	13	past	past	JJ
cord-000238-om92cx5q	318	14	evolution	evolution	NN
cord-000238-om92cx5q	318	15	of	of	IN
cord-000238-om92cx5q	318	16	parasites	parasite	NNS
cord-000238-om92cx5q	318	17	such	such	JJ
cord-000238-om92cx5q	318	18	as	as	IN
cord-000238-om92cx5q	318	19	influenza	influenza	NN
cord-000238-om92cx5q	318	20	A	a	DT
cord-000238-om92cx5q	318	21	virus	virus	NN
cord-000238-om92cx5q	318	22	and	and	CC
cord-000238-om92cx5q	318	23	P.	p.	NN
cord-000238-om92cx5q	318	24	falciparum	falciparum	NNS
cord-000238-om92cx5q	318	25	,	,	,
cord-000238-om92cx5q	318	26	and	and	CC
cord-000238-om92cx5q	318	27	to	to	TO
cord-000238-om92cx5q	318	28	predict	predict	VB
cord-000238-om92cx5q	318	29	how	how	WRB
cord-000238-om92cx5q	318	30	it	-PRON-	PRP
cord-000238-om92cx5q	318	31	might	may	MD
cord-000238-om92cx5q	318	32	play	play	VB
cord-000238-om92cx5q	318	33	a	a	DT
cord-000238-om92cx5q	318	34	role	role	NN
cord-000238-om92cx5q	318	35	in	in	IN
cord-000238-om92cx5q	318	36	their	-PRON-	PRP$
cord-000238-om92cx5q	318	37	future	future	JJ
cord-000238-om92cx5q	318	38	evolutionary	evolutionary	JJ
cord-000238-om92cx5q	318	39	change	change	NN
cord-000238-om92cx5q	318	40	.	.	.
cord-000238-om92cx5q	319	1	Empirical	empirical	JJ
cord-000238-om92cx5q	319	2	evidence	evidence	NN
cord-000238-om92cx5q	319	3	for	for	IN
cord-000238-om92cx5q	319	4	unifying	unifying	JJ
cord-000238-om92cx5q	319	5	principles	principle	NNS
cord-000238-om92cx5q	319	6	in	in	IN
cord-000238-om92cx5q	319	7	biology	biology	NN
cord-000238-om92cx5q	319	8	is	be	VBZ
cord-000238-om92cx5q	319	9	often	often	RB
cord-000238-om92cx5q	319	10	sought	seek	VBN
cord-000238-om92cx5q	319	11	,	,	,
cord-000238-om92cx5q	319	12	but	but	CC
cord-000238-om92cx5q	319	13	is	be	VBZ
cord-000238-om92cx5q	319	14	not	not	RB
cord-000238-om92cx5q	319	15	easily	easily	RB
cord-000238-om92cx5q	319	16	achieved	achieve	VBN
cord-000238-om92cx5q	319	17	.	.	.
cord-000238-om92cx5q	320	1	One	one	CD
cord-000238-om92cx5q	320	2	consequence	consequence	NN
cord-000238-om92cx5q	320	3	of	of	IN
cord-000238-om92cx5q	320	4	earth	earth	NN
cord-000238-om92cx5q	320	5	's	's	POS
cord-000238-om92cx5q	320	6	biodiversity	biodiversity	NN
cord-000238-om92cx5q	320	7	is	be	VBZ
cord-000238-om92cx5q	320	8	that	that	IN
cord-000238-om92cx5q	320	9	exceptions	exception	NNS
cord-000238-om92cx5q	320	10	to	to	IN
cord-000238-om92cx5q	320	11	general	general	JJ
cord-000238-om92cx5q	320	12	rules	rule	NNS
cord-000238-om92cx5q	320	13	are	be	VBP
cord-000238-om92cx5q	320	14	often	often	RB
cord-000238-om92cx5q	320	15	found	find	VBN
cord-000238-om92cx5q	320	16	if	if	IN
cord-000238-om92cx5q	320	17	one	one	CD
cord-000238-om92cx5q	320	18	searches	search	VBZ
cord-000238-om92cx5q	320	19	hard	hard	RB
cord-000238-om92cx5q	320	20	enough	enough	RB
cord-000238-om92cx5q	320	21	.	.	.
cord-000238-om92cx5q	321	1	For	for	IN
cord-000238-om92cx5q	321	2	example	example	NN
cord-000238-om92cx5q	321	3	,	,	,
cord-000238-om92cx5q	321	4	a	a	DT
cord-000238-om92cx5q	321	5	popular	popular	JJ
cord-000238-om92cx5q	321	6	notion	notion	NN
cord-000238-om92cx5q	321	7	in	in	IN
cord-000238-om92cx5q	321	8	biomedicine	biomedicine	NN
cord-000238-om92cx5q	321	9	was	be	VBD
cord-000238-om92cx5q	321	10	that	that	IN
cord-000238-om92cx5q	321	11	parasites	parasite	NNS
cord-000238-om92cx5q	321	12	should	should	MD
cord-000238-om92cx5q	321	13	inevitably	inevitably	RB
cord-000238-om92cx5q	321	14	evolve	evolve	VB
cord-000238-om92cx5q	321	15	to	to	TO
cord-000238-om92cx5q	321	16	become	become	VB
cord-000238-om92cx5q	321	17	mutualistic	mutualistic	JJ
cord-000238-om92cx5q	321	18	to	to	IN
cord-000238-om92cx5q	321	19	their	-PRON-	PRP$
cord-000238-om92cx5q	321	20	hosts	host	NNS
cord-000238-om92cx5q	321	21	,	,	,
cord-000238-om92cx5q	321	22	because	because	IN
cord-000238-om92cx5q	321	23	this	this	DT
cord-000238-om92cx5q	321	24	would	would	MD
cord-000238-om92cx5q	321	25	afford	afford	VB
cord-000238-om92cx5q	321	26	long	long	JJ
cord-000238-om92cx5q	321	27	-	-	HYPH
cord-000238-om92cx5q	321	28	term	term	NN
cord-000238-om92cx5q	321	29	survival	survival	NN
cord-000238-om92cx5q	321	30	of	of	IN
cord-000238-om92cx5q	321	31	a	a	DT
cord-000238-om92cx5q	321	32	parasite	parasite	NN
cord-000238-om92cx5q	321	33	species	specie	NNS
cord-000238-om92cx5q	321	34	that	that	WDT
cord-000238-om92cx5q	321	35	might	may	MD
cord-000238-om92cx5q	321	36	otherwise	otherwise	RB
cord-000238-om92cx5q	321	37	force	force	VB
cord-000238-om92cx5q	321	38	its	-PRON-	PRP$
cord-000238-om92cx5q	321	39	host	host	NN
cord-000238-om92cx5q	321	40	into	into	IN
cord-000238-om92cx5q	321	41	extinction	extinction	NN
cord-000238-om92cx5q	321	42	.	.	.
cord-000238-om92cx5q	322	1	However	however	RB
cord-000238-om92cx5q	322	2	,	,	,
cord-000238-om92cx5q	322	3	theory	theory	NN
cord-000238-om92cx5q	322	4	and	and	CC
cord-000238-om92cx5q	322	5	experiments	experiment	NNS
cord-000238-om92cx5q	322	6	later	later	RB
cord-000238-om92cx5q	322	7	overturned	overturn	VBD
cord-000238-om92cx5q	322	8	this	this	DT
cord-000238-om92cx5q	322	9	conventional	conventional	JJ
cord-000238-om92cx5q	322	10	wisdom	wisdom	NN
cord-000238-om92cx5q	322	11	by	by	IN
cord-000238-om92cx5q	322	12	demonstrating	demonstrate	VBG
cord-000238-om92cx5q	322	13	that	that	IN
cord-000238-om92cx5q	322	14	infectious	infectious	JJ
cord-000238-om92cx5q	322	15	parasites	parasite	NNS
cord-000238-om92cx5q	322	16	may	may	MD
cord-000238-om92cx5q	322	17	evolve	evolve	VB
cord-000238-om92cx5q	322	18	greater	great	JJR
cord-000238-om92cx5q	322	19	or	or	CC
cord-000238-om92cx5q	322	20	lesser	less	JJR
cord-000238-om92cx5q	322	21	virulence	virulence	NN
cord-000238-om92cx5q	322	22	͑damage	͑damage	VBN
cord-000238-om92cx5q	322	23	to	to	IN
cord-000238-om92cx5q	322	24	the	the	DT
cord-000238-om92cx5q	322	25	host͒	host͒	NN
cord-000238-om92cx5q	322	26	depending	depend	VBG
cord-000238-om92cx5q	322	27	on	on	IN
cord-000238-om92cx5q	322	28	their	-PRON-	PRP$
cord-000238-om92cx5q	322	29	unique	unique	JJ
cord-000238-om92cx5q	322	30	ecologies	ecology	NNS
cord-000238-om92cx5q	322	31	.	.	.
cord-000238-om92cx5q	323	1	[	[	-LRB-
cord-000238-om92cx5q	323	2	71	71	CD
cord-000238-om92cx5q	323	3	]	]	-RRB-
cord-000238-om92cx5q	323	4	[	[	-LRB-
cord-000238-om92cx5q	323	5	72	72	CD
cord-000238-om92cx5q	323	6	]	]	-RRB-
cord-000238-om92cx5q	323	7	[	[	-LRB-
cord-000238-om92cx5q	323	8	73	73	CD
cord-000238-om92cx5q	323	9	]	]	-RRB-
cord-000238-om92cx5q	323	10	[	[	-LRB-
cord-000238-om92cx5q	323	11	74	74	CD
cord-000238-om92cx5q	323	12	]	]	-RRB-
cord-000238-om92cx5q	324	1	Similarly	similarly	RB
cord-000238-om92cx5q	324	2	,	,	,
cord-000238-om92cx5q	324	3	it	-PRON-	PRP
cord-000238-om92cx5q	324	4	should	should	MD
cord-000238-om92cx5q	324	5	be	be	VB
cord-000238-om92cx5q	324	6	expected	expect	VBN
cord-000238-om92cx5q	324	7	that	that	IN
cord-000238-om92cx5q	324	8	evolution	evolution	NN
cord-000238-om92cx5q	324	9	of	of	IN
cord-000238-om92cx5q	324	10	robustness	robustness	NN
cord-000238-om92cx5q	324	11	and	and	CC
cord-000238-om92cx5q	324	12	its	-PRON-	PRP$
cord-000238-om92cx5q	324	13	underlying	underlying	JJ
cord-000238-om92cx5q	324	14	mechanism	mechanism	NN
cord-000238-om92cx5q	324	15	might	may	MD
cord-000238-om92cx5q	324	16	differ	differ	VB
cord-000238-om92cx5q	324	17	substantially	substantially	RB
cord-000238-om92cx5q	324	18	across	across	IN
cord-000238-om92cx5q	324	19	the	the	DT
cord-000238-om92cx5q	324	20	biosphere	biosphere	NN
cord-000238-om92cx5q	324	21	.	.	.
cord-000238-om92cx5q	325	1	Therefore	therefore	RB
cord-000238-om92cx5q	325	2	,	,	,
cord-000238-om92cx5q	325	3	caution	caution	NN
cord-000238-om92cx5q	325	4	is	be	VBZ
cord-000238-om92cx5q	325	5	warranted	warrant	VBN
cord-000238-om92cx5q	325	6	when	when	WRB
cord-000238-om92cx5q	325	7	attempting	attempt	VBG
cord-000238-om92cx5q	325	8	to	to	TO
cord-000238-om92cx5q	325	9	draw	draw	VB
cord-000238-om92cx5q	325	10	widespread	widespread	JJ
cord-000238-om92cx5q	325	11	conclusions	conclusion	NNS
cord-000238-om92cx5q	325	12	from	from	IN
cord-000238-om92cx5q	325	13	the	the	DT
cord-000238-om92cx5q	325	14	handful	handful	NN
cord-000238-om92cx5q	325	15	of	of	IN
cord-000238-om92cx5q	325	16	valuable	valuable	JJ
cord-000238-om92cx5q	325	17	empirical	empirical	JJ
cord-000238-om92cx5q	325	18	studies	study	NNS
cord-000238-om92cx5q	325	19	on	on	IN
cord-000238-om92cx5q	325	20	evolution	evolution	NN
cord-000238-om92cx5q	325	21	of	of	IN
cord-000238-om92cx5q	325	22	robustness	robustness	NN
cord-000238-om92cx5q	325	23	.	.	.
cord-000238-om92cx5q	326	1	Perhaps	perhaps	RB
cord-000238-om92cx5q	326	2	it	-PRON-	PRP
cord-000238-om92cx5q	326	3	is	be	VBZ
cord-000238-om92cx5q	326	4	possible	possible	JJ
cord-000238-om92cx5q	326	5	to	to	TO
cord-000238-om92cx5q	326	6	construct	construct	VB
cord-000238-om92cx5q	326	7	a	a	DT
cord-000238-om92cx5q	326	8	universal	universal	JJ
cord-000238-om92cx5q	326	9	theory	theory	NN
cord-000238-om92cx5q	326	10	of	of	IN
cord-000238-om92cx5q	326	11	robustness	robustness	NN
cord-000238-om92cx5q	326	12	that	that	WDT
cord-000238-om92cx5q	326	13	applies	apply	VBZ
cord-000238-om92cx5q	326	14	everywhere	everywhere	RB
cord-000238-om92cx5q	326	15	,	,	,
cord-000238-om92cx5q	326	16	but	but	CC
cord-000238-om92cx5q	326	17	this	this	DT
cord-000238-om92cx5q	326	18	is	be	VBZ
cord-000238-om92cx5q	326	19	unknown	unknown	JJ
cord-000238-om92cx5q	326	20	.	.	.
cord-000238-om92cx5q	327	1	Our	-PRON-	PRP$
cord-000238-om92cx5q	327	2	hope	hope	NN
cord-000238-om92cx5q	327	3	is	be	VBZ
cord-000238-om92cx5q	327	4	that	that	IN
cord-000238-om92cx5q	327	5	the	the	DT
cord-000238-om92cx5q	327	6	exciting	exciting	JJ
cord-000238-om92cx5q	327	7	studies	study	NNS
cord-000238-om92cx5q	327	8	and	and	CC
cord-000238-om92cx5q	327	9	biological	biological	JJ
cord-000238-om92cx5q	327	10	examples	example	NNS
cord-000238-om92cx5q	327	11	presented	present	VBN
cord-000238-om92cx5q	327	12	here	here	RB
cord-000238-om92cx5q	327	13	will	will	MD
cord-000238-om92cx5q	327	14	further	further	RB
cord-000238-om92cx5q	327	15	motivate	motivate	VB
cord-000238-om92cx5q	327	16	researchers	researcher	NNS
cord-000238-om92cx5q	327	17	in	in	IN
cord-000238-om92cx5q	327	18	basic	basic	JJ
cord-000238-om92cx5q	327	19	science	science	NN
cord-000238-om92cx5q	327	20	and	and	CC
cord-000238-om92cx5q	327	21	biomedicine	biomedicine	NN
cord-000238-om92cx5q	327	22	to	to	TO
cord-000238-om92cx5q	327	23	consider	consider	VB
cord-000238-om92cx5q	327	24	the	the	DT
cord-000238-om92cx5q	327	25	potential	potential	JJ
cord-000238-om92cx5q	327	26	importance	importance	NN
cord-000238-om92cx5q	327	27	of	of	IN
cord-000238-om92cx5q	327	28	genetic	genetic	JJ
cord-000238-om92cx5q	327	29	and	and	CC
cord-000238-om92cx5q	327	30	environmental	environmental	JJ
cord-000238-om92cx5q	327	31	robustness	robustness	NN
cord-000238-om92cx5q	327	32	in	in	IN
cord-000238-om92cx5q	327	33	a	a	DT
cord-000238-om92cx5q	327	34	great	great	JJ
cord-000238-om92cx5q	327	35	variety	variety	NN
cord-000238-om92cx5q	327	36	of	of	IN
cord-000238-om92cx5q	327	37	biological	biological	JJ
cord-000238-om92cx5q	327	38	systems	system	NNS
cord-000238-om92cx5q	327	39	.	.	.
cord-000238-om92cx5q	328	1	With	with	IN
cord-000238-om92cx5q	328	2	this	this	DT
cord-000238-om92cx5q	328	3	impetus	impetus	NN
cord-000238-om92cx5q	328	4	,	,	,
cord-000238-om92cx5q	328	5	we	-PRON-	PRP
cord-000238-om92cx5q	328	6	may	may	MD
cord-000238-om92cx5q	328	7	amass	amass	VB
cord-000238-om92cx5q	328	8	enough	enough	JJ
cord-000238-om92cx5q	328	9	empirical	empirical	JJ
cord-000238-om92cx5q	328	10	data	datum	NNS
cord-000238-om92cx5q	328	11	to	to	TO
cord-000238-om92cx5q	328	12	help	help	VB
cord-000238-om92cx5q	328	13	bridge	bridge	VB
cord-000238-om92cx5q	328	14	the	the	DT
cord-000238-om92cx5q	328	15	intellectual	intellectual	JJ
cord-000238-om92cx5q	328	16	gap	gap	NN
cord-000238-om92cx5q	328	17	separating	separate	VBG
cord-000238-om92cx5q	328	18	abundant	abundant	JJ
cord-000238-om92cx5q	328	19	theory	theory	NN
cord-000238-om92cx5q	328	20	on	on	IN
cord-000238-om92cx5q	328	21	robustness	robustness	NN
cord-000238-om92cx5q	328	22	evolution	evolution	NN
cord-000238-om92cx5q	328	23	and	and	CC
cord-000238-om92cx5q	328	24	application	application	NN
cord-000238-om92cx5q	328	25	of	of	IN
cord-000238-om92cx5q	328	26	this	this	DT
cord-000238-om92cx5q	328	27	thinking	thinking	NN
cord-000238-om92cx5q	328	28	to	to	IN
cord-000238-om92cx5q	328	29	applied	apply	VBN
cord-000238-om92cx5q	328	30	problems	problem	NNS
cord-000238-om92cx5q	328	31	in	in	IN
cord-000238-om92cx5q	328	32	biomedicine	biomedicine	NN
cord-000238-om92cx5q	328	33	and	and	CC
cord-000238-om92cx5q	328	34	public	public	JJ
cord-000238-om92cx5q	328	35	health	health	NN
cord-000238-om92cx5q	328	36	.	.	.
cord-000238-om92cx5q	329	1	UNCF	UNCF	NNP
cord-000238-om92cx5q	329	2	-	-	HYPH
cord-000238-om92cx5q	329	3	Merck	Merck	NNP
cord-000238-om92cx5q	329	4	and	and	CC
cord-000238-om92cx5q	329	5	by	by	IN
cord-000238-om92cx5q	329	6	the	the	DT
cord-000238-om92cx5q	329	7	National	National	NNP
cord-000238-om92cx5q	329	8	Institutes	Institutes	NNPS
cord-000238-om92cx5q	329	9	of	of	IN
cord-000238-om92cx5q	329	10	Health	Health	NNP
cord-000238-om92cx5q	329	11	training	training	NN
cord-000238-om92cx5q	330	1	͑Grant	͑Grant	.
cord-000238-om92cx5q	331	1	No	no	UH
cord-000238-om92cx5q	331	2	.	.	.
cord-000238-om92cx5q	332	1	T32GM07205͒	T32GM07205͒	NNP
cord-000238-om92cx5q	333	1	Evolution	evolution	NN
cord-000238-om92cx5q	333	2	͑Lawrence	͑lawrence	NN
cord-000238-om92cx5q	333	3	Bacteriophage	bacteriophage	NN
cord-000238-om92cx5q	333	4	Ecology	ecology	NN
cord-000238-om92cx5q	333	5	:	:	:
cord-000238-om92cx5q	333	6	Population	population	NN
cord-000238-om92cx5q	333	7	Growth	Growth	NNP
cord-000238-om92cx5q	333	8	,	,	,
cord-000238-om92cx5q	333	9	Evolution	evolution	NN
cord-000238-om92cx5q	333	10	,	,	,
cord-000238-om92cx5q	333	11	and	and	CC
cord-000238-om92cx5q	333	12	Impact	impact	NN
cord-000238-om92cx5q	333	13	of	of	IN
cord-000238-om92cx5q	333	14	Bacterial	bacterial	JJ
cord-000238-om92cx5q	333	15	Viruses	Viruses	NNPS
cord-000238-om92cx5q	333	16	Role	role	NN
cord-000238-om92cx5q	333	17	of	of	IN
cord-000238-om92cx5q	333	18	evolved	evolve	VBN
cord-000238-om92cx5q	333	19	host	host	NN
cord-000238-om92cx5q	333	20	breadth	breadth	NN
cord-000238-om92cx5q	333	21	in	in	IN
cord-000238-om92cx5q	333	22	the	the	DT
cord-000238-om92cx5q	333	23	initial	initial	JJ
cord-000238-om92cx5q	333	24	emergence	emergence	NN
cord-000238-om92cx5q	333	25	of	of	IN
cord-000238-om92cx5q	333	26	an	an	DT
cord-000238-om92cx5q	333	27	RNA	RNA	NNP
cord-000238-om92cx5q	333	28	virus	virus	NN
cord-000238-om92cx5q	333	29	Evolution	evolution	NN
cord-000238-om92cx5q	333	30	͑Lawrence	͑Lawrence	NNP
cord-000238-om92cx5q	333	31	,	,	,
cord-000238-om92cx5q	333	32	Kans.͒	Kans.͒	NNP
cord-000238-om92cx5q	333	33	48	48	CD
cord-000238-om92cx5q	334	1	We	-PRON-	PRP
cord-000238-om92cx5q	334	2	thank	thank	VBP
cord-000238-om92cx5q	334	3	D.	D.	NNP
cord-000238-om92cx5q	334	4	Fish	Fish	NNP
cord-000238-om92cx5q	334	5	,	,	,
cord-000238-om92cx5q	334	6	A.	A.	NNP
cord-000238-om92cx5q	334	7	Galvani	Galvani	NNP
cord-000238-om92cx5q	334	8	,	,	,
cord-000238-om92cx5q	334	9	B.	B.	NNP
cord-000238-om92cx5q	334	10	Lindenbach	Lindenbach	NNP
cord-000238-om92cx5q	334	11	,	,	,
cord-000238-om92cx5q	334	12	E.	E.	NNP
cord-000238-om92cx5q	334	13	Vrba	Vrba	NNP
cord-000238-om92cx5q	334	14	,	,	,
cord-000238-om92cx5q	334	15	G.	G.	NNP
cord-000238-om92cx5q	334	16	Wagner	Wagner	NNP
cord-000238-om92cx5q	334	17	,	,	,
cord-000238-om92cx5q	334	18	and	and	CC
cord-000238-om92cx5q	334	19	the	the	DT
cord-000238-om92cx5q	334	20	Turner	Turner	NNP
cord-000238-om92cx5q	334	21	laboratory	laboratory	NN
cord-000238-om92cx5q	334	22	group	group	NN
cord-000238-om92cx5q	334	23	for	for	IN
cord-000238-om92cx5q	334	24	helpful	helpful	JJ
cord-000238-om92cx5q	334	25	comments	comment	NNS
cord-000238-om92cx5q	334	26	and	and	CC
cord-000238-om92cx5q	334	27	discussion	discussion	NN
cord-000238-om92cx5q	334	28	.	.	.
cord-000238-om92cx5q	335	1	This	this	DT
cord-000238-om92cx5q	335	2	work	work	NN
cord-000238-om92cx5q	335	3	was	be	VBD
cord-000238-om92cx5q	335	4	partially	partially	RB
cord-000238-om92cx5q	335	5	funded	fund	VBN
cord-000238-om92cx5q	335	6	by	by	IN
cord-000238-om92cx5q	335	7	a	a	DT
cord-000238-om92cx5q	335	8	 	 	_SP