id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352465-n746e8qt	Wang, Fei	Targeting stress granules: A novel therapeutic strategy for human diseases	2020-08-16		.txt	text/plain	9128	555	40	Chronic stress might even induce formation of cytotoxic pathological SGs. SGs participate in various biological functions including response to apoptosis, inflammation, immune modulation, and signalling pathways; moreover, SGs are involved in pathogenesis of neurodegenerative diseases, viral infection, aging, cancers and many other diseases. One of the most studied mRNP granules is SGs. SGs are a type of dynamic granular substance formed of mRNA of stagnant translation and RBPs in the cytoplasm of eukaryotic cells, the formation of which is stimulated by various stresses including oxidative stress, heat shock, hypoxia, or viral infection (Fig. 1) . For example, eIF2α phosphorylation-dependent SGs (Type I) induced by sodium arsenite (SA) and bortezomib [40] may protect cells in the stress response, inhibit apoptosis and promote cell survival by the sequestration of signalling molecules, such as RACK1 [41] , ROCK1 [42] and Raptor [43] .	./cache/cord-352465-n746e8qt.txt	./txt/cord-352465-n746e8qt.txt