id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347302-ylnb6qfl	van der Schaar, Hilde M.	Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles	2016-03-22		.txt	text/plain	5330	266	36	Replication organelles (ROs) are membranous structures that not only harbor viral proteins but also contain a specific array of hijacked host factors that create a unique lipid microenvironment optimal for genome replication. Whatever function GBF1 plays in enterovirus replication, it might be related to the functioning rather than the formation of ROs, because poliovirus proteins expressed in the presence of BFA induced membrane rearrangements indistinguishable from those found in infected cells [43] . The Importance of MCSs for Controlling the Metabolism of Other Lipids in Infected Cells Besides mediating cholesterol/PI4P exchange, OSBP regulates the homeostasis of other lipids via MCSs. Notably, OSBP regulates the ceramide transfer protein (CERT)-dependent shuttling of ceramide (a precursor of sphingomyelin, a lipid that associates with cholesterol in membrane microdomains) from ER to trans-Golgi [70] . Since RO membranes are enriched in PI4P, ORP5 and/or ORP8 may also be recruited to ER-RO MCSs and transport phosphatidylserine to ROs, from where it may transition to the autophagosome-like DMVs. Enterovirus replication has been associated with alterations of other lipid metabolic pathways as well.	./cache/cord-347302-ylnb6qfl.txt	./txt/cord-347302-ylnb6qfl.txt