id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341034-2oigu75k	Moser, Theresa S.	AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis	2012-04-19		.txt	text/plain	9932	511	45	We found that the energy regulator AMPK, which potently inhibits fatty acid synthesis, restricts infection of the Bunyavirus, Rift Valley Fever Virus (RVFV), an important re-emerging arthropod-borne human pathogen for which there are no effective vaccines or therapeutics. Furthermore, we found that AMPK is activated during RVFV infection, leading to the phosphorylation and inhibition of acetyl-CoA carboxylase, the first rate-limiting enzyme in fatty acid synthesis. Consistent with a role for AMPK both in early events during viral replication and in spread as measured by plaque assay Figure 1A ), we observed an increase in viral infection at early time points before virus spread, as well as increased spread in cells lacking AMPK by monitoring the production of RVFV N protein over time by microscopy ( Figure S1A-B) . We have found that energy-mediated activation of AMPK restricts infection of the Bunyavirus Rift Valley fever virus by decreasing levels of fatty acid synthesis.	./cache/cord-341034-2oigu75k.txt	./txt/cord-341034-2oigu75k.txt