id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317773-jdq1d98i	Meng, Qing-Wen	Enhanced inhibition of Avian leukosis virus subgroup J replication by multi-target miRNAs	2011-12-22		.txt	text/plain	3614	214	53	RESULTS: In this study, the avian leukosis virus subgroup J (ALV-J) proviral genome, including the gag genes, were treated as targets for RNAi. Four pairs of miRNA sequences were designed and synthesized that targeted different regions of the gag gene. To avoid the generation of escape variants during virus infection, expression vectors of multi-target miRNAs were constructed using the multi-target serial strategy (against different regions of the gag, pol, and env genes). CONCLUSION: The strategy of multi-target miRNAs might be an effective method for inhibiting ALV replication and the acquisition of resistant mutations. In some studies, transfection of siRNA designed to target C virus (HCV) remarkably inhibited the expression of virus-specific proteins and protected cells against HCV RNA, in vitro [4, 5] . In another study, Hepatitis B virus (HBV) replication was successfully inhibited after plasmid expression of HBV siRNA transfected into mouse liver [6] .	./cache/cord-317773-jdq1d98i.txt	./txt/cord-317773-jdq1d98i.txt